format-version: 1.2 data-version: releases/2025-10-29 subsetdef: 1_STAR "" subsetdef: 2_STAR "" subsetdef: 3_STAR "" subsetdef: abnormal_slim "" subsetdef: absent_slim "" subsetdef: added_for_HCA "" subsetdef: attribute_slim "" subsetdef: BDS_subset "" subsetdef: blood_and_immune_upper_slim "" subsetdef: cell_quality "" subsetdef: cellxgene_subset "" subsetdef: common_anatomy "" subsetdef: cumbo "" subsetdef: developmental_classification "" subsetdef: disposition_slim "" subsetdef: early_development "" subsetdef: efo_slim "" subsetdef: emapa_ehdaa2 "" subsetdef: eye_upper_slim "" subsetdef: functional_classification "" subsetdef: general_cell_types_upper_slim "" subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_obsoletion_candidate "" subsetdef: goslim_agr "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" subsetdef: goslim_drosophila "" subsetdef: goslim_euk_cellular_processes_ribbon "" subsetdef: goslim_flybase_ribbon "" subsetdef: goslim_generic "" subsetdef: goslim_metagenomics "" subsetdef: goslim_mouse "" subsetdef: goslim_pir "" subsetdef: goslim_plant "" subsetdef: goslim_plant_ribbon "" subsetdef: goslim_pombe "" subsetdef: goslim_prokaryote "" subsetdef: goslim_prokaryote_ribbon "" subsetdef: goslim_synapse "" subsetdef: goslim_virus "" subsetdef: goslim_yeast "" subsetdef: grouping_class "" subsetdef: homology_grouping "" subsetdef: hpo_slim "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" subsetdef: human_reference_atlas "" subsetdef: human_subset "" subsetdef: inconsistent_with_fma "" subsetdef: major_organ "" subsetdef: mouse_subset "" subsetdef: mpath_slim "" subsetdef: non_informative "" subsetdef: organ_slim "" subsetdef: pheno_slim "" subsetdef: phenotype_rcn "" subsetdef: relational_slim "" subsetdef: ro-eco "" subsetdef: RO:0002259 "" subsetdef: scalar_slim "" subsetdef: uberon_slim "" subsetdef: ubprop:upper_level "" subsetdef: unverified_taxonomic_grouping "" subsetdef: upper_level "" subsetdef: value_slim "" subsetdef: vertebrate_core "" idspace: dc http://purl.org/dc/elements/1.1/ idspace: foaf http://xmlns.com/foaf/0.1/ idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# idspace: swrl http://www.w3.org/2003/11/swrl# idspace: swrla http://swrl.stanford.edu/ontologies/3.3/swrla.owl# idspace: swrlb http://www.w3.org/2003/11/swrlb# idspace: terms http://purl.org/dc/terms/ ontology: phipo property_value: dc:description "Ontology of species-neutral phenotypes observed in pathogen-host interactions." xsd:string property_value: dc:title "Pathogen Host Interactions Phenotype Ontology" xsd:string property_value: owl:versionInfo "2025-10-29" xsd:string property_value: terms:license "https://creativecommons.org/licenses/by/3.0/" xsd:string creation_date: 2018-07-09T13:43:00Z created_by: alaynecuzick [Term] id: BFO:0000001 name: entity [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] is_a: BFO:0000001 ! entity disjoint_from: BFO:0000003 ! occurrent relationship: BFO:0000050 BFO:0000002 {all_only="true"} ! part of continuant [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] is_a: BFO:0000001 ! entity relationship: BFO:0000050 BFO:0000003 {all_only="true"} ! part of occurrent [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: BFO:0000050 BFO:0000004 {all_only="true"} ! part of independent continuant [Term] id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. is_a: BFO:0000003 ! occurrent [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity disjoint_from: BFO:0000023 ! role [Term] id: BFO:0000017 name: realizable entity def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] is_a: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000019 ! quality relationship: BFO:0000050 BFO:0000017 {all_only="true"} ! part of realizable entity [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: BFO:0000050 BFO:0000019 {all_only="true"} ! part of quality [Term] id: BFO:0000020 name: specifically dependent continuant def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." [] comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: BFO:0000050 BFO:0000020 {all_only="true"} ! part of specifically dependent continuant [Term] id: BFO:0000023 name: role def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." [] is_a: BFO:0000017 ! realizable entity [Term] id: BFO:0000031 name: generically dependent continuant def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." [] is_a: BFO:0000002 ! continuant relationship: BFO:0000050 BFO:0000031 {all_only="true"} ! part of generically dependent continuant [Term] id: BFO:0000034 name: function is_a: BFO:0000016 ! disposition [Term] id: BFO:0000040 name: material entity def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 [Term] id: CARO:0000000 name: anatomical entity def: "A part of a multicellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a multicellular organism with granularity above the level of a protein complex." [] is_a: BFO:0000040 ! material entity disjoint_from: IDO:0000528 ! pathogen [Term] id: CHEBI:100147 name: nalidixic acid namespace: chebi_ontology alt_id: CHEBI:7456 def: "A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species." [] subset: 3_STAR synonym: "1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid" RELATED [ChemIDplus] synonym: "1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure" RELATED [ChemIDplus] synonym: "1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid" RELATED [ChemIDplus] synonym: "1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid" RELATED [ChemIDplus] synonym: "1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid" RELATED [ChEMBL] synonym: "3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one" RELATED [ChemIDplus] synonym: "NALIDIXIC ACID" EXACT [ChEMBL] synonym: "Nalidixic acid" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00779 xref: KEGG:C05079 xref: KEGG:D00183 xref: LINCS:LSM-5590 xref: Patent:BE612258 xref: Patent:US3590036 xref: PDBeChem:NIX xref: VSDB:1880 xref: Wikipedia:Nalidixic_Acid is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:73537 ! 1,8-naphthyridine derivative is_a: CHEBI:86324 ! quinolone antibiotic relationship: is_conjugate_acid_of CHEBI:62070 ! nalidixic acid anion relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor [Term] id: CHEBI:10022 name: deoxynivalenol namespace: chebi_ontology def: "A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination." [] subset: 3_STAR synonym: "3alpha,7alpha,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one" RELATED [ChemIDplus] synonym: "4-Deoxynivalenol" RELATED [ChemIDplus] synonym: "4-Desoxynivalenol" RELATED [ChemIDplus] synonym: "Dehydronivalenol" RELATED [ChemIDplus] synonym: "Desoxynivalenol" RELATED [ChemIDplus] synonym: "DON" RELATED [KEGG_COMPOUND] synonym: "Vomitoxin" RELATED [KEGG_COMPOUND] xref: Chemspider:36584 xref: KEGG:C09747 xref: KNApSAcK:C00003201 xref: Wikipedia:Vomitoxin is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:2468 ! secondary alpha-hydroxy ketone is_a: CHEBI:27136 ! triol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:51689 ! enone is_a: CHEBI:55517 ! trichothecene [Term] id: CHEBI:10023 name: voriconazole namespace: chebi_ontology alt_id: CHEBI:127308 def: "A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4." [] subset: 3_STAR synonym: "(alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol" RELATED [ChemIDplus] synonym: "(R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol" RELATED [ChEBI] synonym: "VCZ" RELATED [DrugBank] synonym: "voriconazole" EXACT [UniProt] xref: DrugBank:DB00582 xref: KEGG:C07622 xref: KEGG:D00578 xref: LINCS:LSM-5244 xref: Patent:EP440372 xref: Patent:US5278175 xref: Wikipedia:Voriconazole is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:38582 ! difluorobenzene is_a: CHEBI:39447 ! pyrimidines is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor [Term] id: CHEBI:100241 name: ciprofloxacin namespace: chebi_ontology alt_id: CHEBI:102718 alt_id: CHEBI:3717 alt_id: CHEBI:41638 def: "A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively." [] subset: 3_STAR synonym: "1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID" RELATED [PDBeChem] synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid" RELATED [ChEMBL] synonym: "Ciprofloxacin" EXACT [KEGG_COMPOUND] synonym: "ciprofloxacin" EXACT [ChEMBL] xref: DrugBank:DB00537 xref: HMDB:HMDB0014677 xref: KEGG:C05349 xref: KEGG:D00186 xref: LINCS:LSM-5226 xref: Patent:DE3142854 xref: Patent:US4670444 xref: PDBeChem:CPF xref: VSDB:1763 xref: Wikipedia:Ciprofloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:36709 ! aminoquinoline is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:51454 ! cyclopropanes is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_base_of CHEBI:192486 ! ciprofloxacin(1+) relationship: is_tautomer_of CHEBI:192484 ! ciprofloxacin zwitterion relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:100246 name: norfloxacin namespace: chebi_ontology alt_id: CHEBI:7629 def: "A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase." [] subset: 3_STAR synonym: "1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure" RELATED [ChemIDplus] synonym: "1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "NFLX" RELATED [KEGG_DRUG] xref: DrugBank:DB01059 xref: HMDB:HMDB0015192 xref: KEGG:C06687 xref: KEGG:D00210 xref: LINCS:LSM-5286 xref: Patent:BE863429 xref: Patent:DE2840910 xref: Patent:US4146719 xref: Patent:US4292317 xref: VSDB:1831 xref: Wikipedia:Norfloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:102484 name: sulfisoxazole namespace: chebi_ontology alt_id: CHEBI:9343 def: "A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms." [] subset: 3_STAR synonym: "3,4-Dimethyl-5-sulfanilamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethyl-5-sulfonamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethyl-5-sulphanilamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethyl-5-sulphonamidoisoxazole" RELATED [ChemIDplus] synonym: "3,4-Dimethylisoxazole-5-sulfanilamide" RELATED [ChemIDplus] synonym: "3,4-Dimethylisoxazole-5-sulphanilamide" RELATED [ChemIDplus] synonym: "4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide" RELATED [NIST_Chemistry_WebBook] synonym: "4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide" RELATED [ChemIDplus] synonym: "5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-Sulfanilamido-3,4-dimethylisoxazole" RELATED [ChemIDplus] synonym: "5-Sulphanilamido-3,4-dimethyl-isoxazole" RELATED [ChemIDplus] synonym: "N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide" RELATED [ChemIDplus] synonym: "N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide" RELATED [ChemIDplus] synonym: "N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide" RELATED [ChemIDplus] synonym: "Sulfadimethylisoxazole" RELATED [DrugBank] synonym: "Sulfafurazol" RELATED [DrugBank] synonym: "Sulfaisoxazole" RELATED [DrugBank] synonym: "Sulfasoxazole" RELATED [DrugBank] synonym: "Sulfisonazole" RELATED [DrugBank] synonym: "Sulfisoxasole" RELATED [DrugBank] synonym: "Sulfisoxazol" RELATED [DrugBank] synonym: "Sulfofurazole" RELATED [DrugBank] synonym: "Sulphadimethylisoxazole" RELATED [NIST_Chemistry_WebBook] synonym: "Sulphafurazol" RELATED [DrugBank] synonym: "Sulphafurazole" RELATED [DrugBank] synonym: "Sulphaisoxazole" RELATED [DrugBank] synonym: "Sulphisoxazol" RELATED [DrugBank] synonym: "Sulphofurazole" RELATED [DrugBank] xref: DrugBank:DB00263 xref: KEGG:C07318 xref: KEGG:D00450 xref: LINCS:LSM-3120 xref: Patent:US2430094 xref: Wikipedia:Sulfisoxazole is_a: CHEBI:55373 ! isoxazoles is_a: CHEBI:87228 ! sulfonamide antibiotic relationship: has_functional_parent CHEBI:45373 ! sulfanilamide relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:10545 name: electron namespace: chebi_ontology def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." [] subset: 3_STAR synonym: "beta" RELATED [IUPAC] synonym: "beta(-)" RELATED [ChEBI] synonym: "beta-particle" RELATED [IUPAC] synonym: "e" RELATED [IUPAC] synonym: "e(-)" RELATED [UniProt] synonym: "e-" RELATED [KEGG_COMPOUND] synonym: "electron" EXACT [ChEBI, KEGG_COMPOUND] synonym: "Elektron" RELATED [ChEBI] synonym: "negatron" RELATED [IUPAC] xref: KEGG:C05359 xref: Wikipedia:Electron is_a: CHEBI:36338 ! lepton [Term] id: CHEBI:10642 name: scyllo-inositol namespace: chebi_ontology alt_id: CHEBI:26614 subset: 3_STAR synonym: "(1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexol" RELATED [IUPAC] synonym: "1,3,5/2,4,6-cyclohexanehexol" RELATED [IUPAC] synonym: "Cocositol" RELATED [NIST_Chemistry_WebBook] synonym: "Quercinitol" RELATED [ChemIDplus] synonym: "Scyllitol" RELATED [ChemIDplus] synonym: "scyllo-Inositol" EXACT [KEGG_COMPOUND] synonym: "scyllo-inositol" EXACT [UniProt] xref: KEGG:C06153 is_a: CHEBI:24848 ! inositol relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:130181 name: calmodulin antagonist namespace: chebi_ontology def: "An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin." [] subset: 3_STAR is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:131604 name: Mycoplasma genitalium metabolite namespace: chebi_ontology def: "Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium." [] subset: 3_STAR synonym: "Mycoplasma genitalium metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite [Term] id: CHEBI:131605 name: dicarboxylic acid monoester(1-) namespace: chebi_ontology def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a dicarboxylic acid monoester." [] subset: 3_STAR is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:36244 ! dicarboxylic acid monoester [Term] id: CHEBI:131609 name: pneumocandin B0 namespace: chebi_ontology def: "An echinocandin initially isolated as a very minor bioactive fermentation product of Glarea lozoyensis (originally known as Zalerion arboricola). Subsequent random mutagenesis work and optimisation of the fermentation medium permitted the industrial production of pneumocandin B0, which is used as the starting point for the synthesis of the antifungal drug caspofungin." [] subset: 3_STAR synonym: "L 688,786" RELATED [ChemIDplus] synonym: "L-688,786" RELATED [ChemIDplus] synonym: "L-688786" RELATED [ChemIDplus] synonym: "pneumocandin B(0)" RELATED [ChemIDplus] synonym: "pneumocardin B(0)" RELATED [ChemIDplus] xref: Wikipedia:Pneumocandin_Bo is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:57248 ! echinocandin relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite [Term] id: CHEBI:131871 name: hydroxy polyunsaturated fatty acid anion namespace: chebi_ontology def: "Any polyunsaturated fatty acid anion carrying one or more hydroxy substituents." [] subset: 3_STAR synonym: "a hydroxy polyunsaturated fatty acid" RELATED [UniProt] synonym: "hydroxy polyunsaturated fatty acid anions" RELATED [ChEBI] synonym: "hydroxy PUFA" RELATED [SUBMITTER] is_a: CHEBI:59835 ! hydroxy fatty acid anion is_a: CHEBI:76567 ! polyunsaturated fatty acid anion relationship: is_conjugate_base_of CHEBI:140345 ! hydroxy polyunsaturated fatty acid [Term] id: CHEBI:131927 name: dicarboxylic acids and O-substituted derivatives namespace: chebi_ontology def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." [] subset: 3_STAR synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI] is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:132130 name: hydroxyquinone namespace: chebi_ontology def: "Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group." [] subset: 3_STAR synonym: "hydroxyquinones" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:36141 ! quinone [Term] id: CHEBI:132142 name: 1,4-naphthoquinones namespace: chebi_ontology def: "A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring." [] subset: 3_STAR is_a: CHEBI:25481 ! naphthoquinone is_a: CHEBI:25830 ! p-quinones [Term] id: CHEBI:132155 name: hydroxynaphthoquinone namespace: chebi_ontology def: "Any naphthoquinone in which the naphthaoquinone moiety is substituted by at least one hydroxy group." [] subset: 3_STAR synonym: "hydroxynaphthoquinones" RELATED [ChEBI] xref: Wikipedia:Hydroxynaphthoquinone is_a: CHEBI:132130 ! hydroxyquinone is_a: CHEBI:25481 ! naphthoquinone [Term] id: CHEBI:132157 name: hydroxy-1,4-naphthoquinone namespace: chebi_ontology def: "Any member of the class of 1,4-naphthoquinones in which the naphthoquinone moiety is substituted by at least one hydroxy group." [] subset: 3_STAR synonym: "hydroxy-1,4-naphthoquinones" RELATED [ChEBI] is_a: CHEBI:132142 ! 1,4-naphthoquinones is_a: CHEBI:132155 ! hydroxynaphthoquinone [Term] id: CHEBI:13248 name: anilide namespace: chebi_ontology def: "Any aromatic amide obtained by acylation of aniline." [] subset: 3_STAR synonym: "an anilide" RELATED [UniProt] synonym: "N-phenyl amide" RELATED [ChEBI] synonym: "N-phenyl amides" RELATED [ChEBI] xref: KEGG:C01402 is_a: CHEBI:22712 ! benzenes is_a: CHEBI:62733 ! aromatic amide relationship: has_functional_parent CHEBI:17296 ! aniline [Term] id: CHEBI:132717 name: bleaching agent namespace: chebi_ontology def: "A reagent that lightens or whitens a substrate through chemical reaction. Bleaching reactions usually involve oxidative or reductive processes that degrade colour systems. Bleaching can occur by destroying one or more of the double bonds in the conjugated chain, by cleaving the conjugated chain, or by oxidation of one of the other moieties in the conjugated chain. Their reactivity results in many bleaches having strong bactericidal, disinfecting, and sterilising properties." [] subset: 3_STAR xref: Wikipedia:Bleach is_a: CHEBI:33893 ! reagent [Term] id: CHEBI:133011 name: oxytetracycline zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the adjacent tertiary amino group of oxytetracycline; major species at pH 7.3." [] subset: 3_STAR synonym: "oxytetracycline" RELATED [UniProt] xref: MetaCyc:CPD-19255 is_a: CHEBI:144644 ! a tetracycline zwitterion is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:27701 ! oxytetracycline [Term] id: CHEBI:133135 name: chromenochromene namespace: chebi_ontology def: "Any organic heteroolycyclic compound whose skeleton two ortho-fused chromene rings, and their derivatives." [] subset: 3_STAR synonym: "chromenochromenes" RELATED [ChEBI] is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:133598 name: chlortetracycline(1-) namespace: chebi_ontology def: "An organic anion that is the major structure of chlortetracycline at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "7-chlorotetracycline" RELATED [UniProt] xref: MetaCyc:CPD-19258 is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:27644 ! chlortetracycline [Term] id: CHEBI:133833 name: benznidazole namespace: chebi_ontology def: "A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease." [] subset: 3_STAR synonym: "2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide" RELATED [ChemIDplus] synonym: "N-Benzyl-2-nitroimidazol-1-yl-acetamide" RELATED [ChemIDplus] synonym: "N-Benzyl-2-nitroimidazole-1-acetamide" RELATED [ChemIDplus] xref: KEGG:D02489 xref: Wikipedia:Benznidazole is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:35716 ! C-nitro compound relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug [Term] id: CHEBI:134179 name: volatile organic compound namespace: chebi_ontology def: "Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa." [] subset: 3_STAR synonym: "VOC" RELATED [ChEBI] synonym: "VOCs" RELATED [ChEBI] synonym: "volatile organic compounds" RELATED [ChEBI] xref: Wikipedia:Volatile_organic_compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:135928 name: doripenem namespace: chebi_ontology subset: 2_STAR synonym: "doribax" RELATED [DrugCentral] synonym: "doripenem hydrate" RELATED [DrugCentral] xref: HMDB:HMDB0041883 is_a: CHEBI:46633 ! carbapenems [Term] id: CHEBI:13643 name: glycol namespace: chebi_ontology def: "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [] subset: 3_STAR synonym: "Glykol" RELATED [ChEBI] is_a: CHEBI:23824 ! diol [Term] id: CHEBI:136622 name: aci-nitro compound namespace: chebi_ontology def: "Organonitrogen compounds that have the general structure R(1)(R(2))C=N(O)OH (R(1),R(2) = H, organyl). They are tautomers of C-nitro compounds." [] subset: 3_STAR synonym: "aci-nitro compounds" RELATED [ChEBI] synonym: "oxime N-oxide" RELATED [ChEBI] synonym: "oxime N-oxides" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_functional_parent CHEBI:25750 ! oxime relationship: is_tautomer_of CHEBI:35716 ! C-nitro compound [Term] id: CHEBI:136651 name: S100 calcium-binding protein B inhibitor namespace: chebi_ontology def: "Any inhibitor of S100 calcium-binding protein B." [] subset: 3_STAR synonym: "S100 calcium-binding protein B inhibitors" RELATED [ChEBI] synonym: "S100B inhibitor" RELATED [ChEBI] synonym: "S100B inhibitors" RELATED [ChEBI] xref: Wikipedia:S100B is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:136859 name: pro-agent namespace: chebi_ontology def: "A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent." [] subset: 3_STAR synonym: "pro-agents" RELATED [ChEBI] synonym: "proagent" RELATED [ChEBI] synonym: "proagents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:137419 name: secondary ammonium ion namespace: chebi_ontology def: "An organic cation obtained by protonation of any secondary amino compound; major species at pH 7.3." [] subset: 3_STAR synonym: "a secondary amine" RELATED [UniProt] synonym: "secondary amine(1+)" RELATED [ChEBI] xref: MetaCyc:Secondary-Amines is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:32863 ! secondary amine [Term] id: CHEBI:137598 name: 4-aminosalicylate(1-) namespace: chebi_ontology def: "An aminobenzoate that is the conjugate base of 4-aminosalicylic acid, obtained by deprotonation of the carboxy group. Major miscrospecies at pH 7.3." [] subset: 3_STAR synonym: "4-aminosalicylate" RELATED [UniProt] xref: MetaCyc:CPD-8817 is_a: CHEBI:22494 ! aminobenzoate is_a: CHEBI:24675 ! hydroxybenzoate relationship: has_functional_parent CHEBI:30762 ! salicylate relationship: is_conjugate_base_of CHEBI:27565 ! 4-aminosalicylic acid [Term] id: CHEBI:137982 name: tertiary ammonium ion namespace: chebi_ontology def: "An organic cation obtained by protonation of the amino group of any tertiary amino compound." [] subset: 3_STAR synonym: "a tertiary amine" RELATED [UniProt] synonym: "tertiary amine(1+)" RELATED [ChEBI] synonym: "tertiary ammonium ions" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:138015 name: endocrine disruptor namespace: chebi_ontology def: "Any compound that can disrupt the functions of the endocrine (hormone) system" [] subset: 3_STAR synonym: "endocrine disrupting chemical" RELATED [ChEBI] synonym: "endocrine disrupting chemicals" RELATED [ChEBI] synonym: "endocrine disrupting compound" RELATED [ChEBI] synonym: "endocrine disrupting compounds" RELATED [ChEBI] synonym: "endocrine disruptors" RELATED [ChEBI] synonym: "endocrine-disrupting chemical" RELATED [ChEBI] synonym: "endocrine-disrupting chemicals" RELATED [ChEBI] synonym: "hormonally active agent" RELATED [ChEBI] synonym: "hormonally active agents" RELATED [ChEBI] xref: Wikipedia:Endocrine_disruptor is_a: CHEBI:51061 ! hormone receptor modulator [Term] id: CHEBI:138103 name: inorganic acid namespace: chebi_ontology def: "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." [] subset: 3_STAR synonym: "inorganic acids" RELATED [ChEBI] synonym: "mineral acid" RELATED [ChEBI] synonym: "mineral acids" RELATED [ChEBI] xref: Wikipedia:Mineral_acid is_a: CHEBI:39141 ! Bronsted acid [Term] id: CHEBI:138675 name: gas molecular entity namespace: chebi_ontology def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." [] subset: 3_STAR synonym: "gas molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entities" RELATED [ChEBI] synonym: "gaseous molecular entity" RELATED [ChEBI] xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas is_a: CHEBI:33579 ! main group molecular entity [Term] id: CHEBI:138856 name: oxolinic acid namespace: chebi_ontology alt_id: CHEBI:44731 alt_id: CHEBI:7848 def: "A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the treatment of bacterial infections in cattle, pigs and poultry." [] subset: 3_STAR synonym: "1-Ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-Ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid" RELATED [ChemIDplus] synonym: "5-Ethyl-5,8-dihydro-8-oxo-1,3-dioxolo(4,5-g)quinoline-7-carboxylic acid" RELATED [ChemIDplus] synonym: "OA" RELATED [KEGG_DRUG] xref: KEGG:C11342 xref: KEGG:D02301 xref: LINCS:LSM-5811 xref: Patent:US3287458 xref: PDBeChem:OXI xref: VSDB:1879 xref: Wikipedia:Oxolinic_acid is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:86324 ! quinolone antibiotic relationship: is_conjugate_acid_of CHEBI:59066 ! oxolinate relationship: RO:0000087 CHEBI:23924 ! has role enzyme inhibitor relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:13941 name: carbamate namespace: chebi_ontology subset: 3_STAR synonym: "Carbamat" RELATED [ChEBI] synonym: "carbamate" EXACT [UniProt] synonym: "carbamate ion" RELATED [ChemIDplus] synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Karbamat" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid [Term] id: CHEBI:139492 name: sensitiser namespace: chebi_ontology def: "A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound." [] subset: 3_STAR synonym: "sensitisers" RELATED [ChEBI] synonym: "sensitizer" RELATED [ChEBI] synonym: "sensitizers" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:139512 name: EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor namespace: chebi_ontology def: "An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of enoyl-[acyl-carrier-protein] reductase (NADH), EC 1.3.1.9." [] subset: 3_STAR synonym: "acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitor" RELATED [ChEBI] synonym: "acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.9 inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.9 inhibitors" RELATED [ChEBI] synonym: "enoyl-[acyl carrier protein] reductase inhibitor" RELATED [ChEBI] synonym: "enoyl-[acyl carrier protein] reductase inhibitors" RELATED [ChEBI] synonym: "enoyl-ACP reductase inhibitor" RELATED [ChEBI] synonym: "enoyl-ACP reductase inhibitors" RELATED [ChEBI] synonym: "ENR inhibitor" RELATED [ChEBI] synonym: "ENR inhibitors" RELATED [ChEBI] synonym: "NADH-enoyl acyl carrier protein reductase inhibitor" RELATED [ChEBI] synonym: "NADH-enoyl acyl carrier protein reductase inhibitors" RELATED [ChEBI] synonym: "NADH-specific enoyl-ACP reductase inhibitor" RELATED [ChEBI] synonym: "NADH-specific enoyl-ACP reductase inhibitors" RELATED [ChEBI] xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor [Term] id: CHEBI:139588 name: alpha-hydroxy ketone namespace: chebi_ontology def: "A ketone containing a hydroxy group on the alpha-carbon relative to the C=O group." [] subset: 3_STAR synonym: "alpha-hydroxy ketones" RELATED [ChEBI] synonym: "alpha-hydroxy-ketone" RELATED [ChEBI] synonym: "alpha-hydroxy-ketones" RELATED [ChEBI] synonym: "alpha-hydroxyketone" RELATED [ChEBI] synonym: "alpha-hydroxyketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:139592 name: tertiary alpha-hydroxy ketone namespace: chebi_ontology def: "An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups." [] subset: 3_STAR synonym: "tertiary alpha-hydroxy ketones" RELATED [ChEBI] synonym: "tertiary alpha-hydroxy-ketone" RELATED [ChEBI] synonym: "tertiary alpha-hydroxy-ketones" RELATED [ChEBI] synonym: "tertiary alpha-hydroxyketone" RELATED [ChEBI] synonym: "tertiary alpha-hydroxyketones" RELATED [ChEBI] is_a: CHEBI:139588 ! alpha-hydroxy ketone is_a: CHEBI:26878 ! tertiary alcohol [Term] id: CHEBI:140190 name: calcium-dependent antibiotics namespace: chebi_ontology def: "Any antimicrobial agent whose activity is dependent on the presence of calcium ions." [] subset: 3_STAR synonym: "Ca(2+)-dependent antibiotic" RELATED [ChEBI] synonym: "Ca(2+)-dependent antibiotics" RELATED [ChEBI] synonym: "Ca-dependent antibiotic" RELATED [ChEBI] synonym: "Ca-dependent antibiotics" RELATED [ChEBI] synonym: "calcium-dependent antibiotic" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:140325 name: secondary carboxamide namespace: chebi_ontology def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1)." [] subset: 3_STAR synonym: "secondary carboxamides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:140326 name: tertiary carboxamide namespace: chebi_ontology def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR(1)R(2)." [] subset: 3_STAR synonym: "tertiary carboxamides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:140345 name: hydroxy polyunsaturated fatty acid namespace: chebi_ontology def: "Any polyunsaturated fatty acid carrying one or more hydroxy substituents." [] subset: 3_STAR is_a: CHEBI:24654 ! hydroxy fatty acid is_a: CHEBI:26208 ! polyunsaturated fatty acid relationship: is_conjugate_acid_of CHEBI:131871 ! hydroxy polyunsaturated fatty acid anion [Term] id: CHEBI:140921 name: Hedgehog signaling pathway inhibitor namespace: chebi_ontology def: "Any pathway inhibitor that inhibits the Hedgehog signalling pathway." [] subset: 3_STAR synonym: "Hedgehog pathway inhibitor" RELATED [ChEBI] synonym: "Hedgehog pathway inhibitors" RELATED [ChEBI] synonym: "Hedgehog signaling pathway inhibitors" RELATED [ChEBI] xref: Wikipedia:Hedgehog_pathway_inhibitors is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:140922 name: glioma-associated oncogene inhibitor namespace: chebi_ontology def: "An inhibitor of any of the glioma-associated oncogene (GLI) proteins." [] subset: 3_STAR synonym: "GLI inhibitor" RELATED [ChEBI] synonym: "GLI inhibitors" RELATED [ChEBI] synonym: "glioma-associated oncogene inhibitors" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor [Term] id: CHEBI:141153 name: quinone outside inhibitor namespace: chebi_ontology def: "A mitochondrial cytochrome-bc1 complex inhibitor that acts at the Quinone 'outer' (Qo) binding site of the cytochrome-bc1 complex." [] subset: 3_STAR synonym: "Qo inhibitor" RELATED [ChEBI] synonym: "Qo inhibitors" RELATED [ChEBI] synonym: "QOI" RELATED [ChEBI] synonym: "QOIs" RELATED [ChEBI] synonym: "quinone outside inhibitors" RELATED [ChEBI] xref: Wikipedia:QoI is_a: CHEBI:24127 ! fungicide is_a: CHEBI:38499 ! mitochondrial cytochrome-bc1 complex inhibitor [Term] id: CHEBI:141498 name: hemiaminal ether namespace: chebi_ontology def: "An organic amino compound that is a hemiaminal in which the hydrogen atom of the hydroxy group has been replaced by an organyl group. General formula: R2C(OR')NR2 ( R =/= H ). Also known as alpha-amino ethers." [] subset: 3_STAR synonym: "alpha-amino ether" RELATED [ChEBI] synonym: "alpha-amino ethers" RELATED [ChEBI] synonym: "hemiaminal ethers" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound is_a: CHEBI:50047 ! organic amino compound relationship: has_functional_parent CHEBI:73080 ! hemiaminal [Term] id: CHEBI:142513 name: oxime anion namespace: chebi_ontology def: "A organic ion resulting from the deprotonation of the hydroxy group of any oxime." [] subset: 3_STAR synonym: "oximate" RELATED [ChEBI] synonym: "oximates" RELATED [ChEBI] synonym: "oxime anion" EXACT [ChEBI] synonym: "oxime anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:25750 ! oxime [Term] id: CHEBI:142708 name: tigecycline(1+) namespace: chebi_ontology def: "An ammonium ion that is the conjugate acid of tigecycline; major species at pH 7.3." [] subset: 3_STAR synonym: "tigecycline" RELATED [UniProt] xref: MetaCyc:CPD-19260 is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:149836 ! tigecycline [Term] id: CHEBI:144644 name: a tetracycline zwitterion namespace: chebi_ontology subset: 2_STAR synonym: "a tetracycline" RELATED [UniProt] is_a: CHEBI:26895 ! tetracyclines [Term] id: CHEBI:145555 name: macropolylide namespace: chebi_ontology def: "Macrolides (macrocyclic lactones) in which the macrocyclic ring contains more than one ester linkage. Macropolylides include macrodiolides, macrotriolides, macrotetrolides and macropentolides, each containing di-, tri-, tetra-, and penta- ester linkages, respectively, in one macrocyclic ring. Macrocyclic lactones containing nitrogen in their skeletons (azamacrolides and macrolide lactams) and also containing oxazole or thiazole in their skeletons are known in nature." [] subset: 3_STAR synonym: "macropolylides" RELATED [ChEBI] is_a: CHEBI:25106 ! macrolide [Term] id: CHEBI:145556 name: macrodiolide namespace: chebi_ontology def: "A macropolylide which contains two ester linkages in one macrocyclic ring." [] subset: 3_STAR synonym: "macrodiolides" RELATED [ChEBI] is_a: CHEBI:145555 ! macropolylide [Term] id: CHEBI:145565 name: macrolide lactam namespace: chebi_ontology def: "A macrolide in which the macrocyclic lactone ring includes an amide group." [] subset: 3_STAR synonym: "macrolide lactams" RELATED [ChEBI] is_a: CHEBI:24995 ! lactam is_a: CHEBI:25106 ! macrolide [Term] id: CHEBI:145790 name: mupirocin(1-) namespace: chebi_ontology def: "A monocarboxylic acid anion that is the conjugate base of mupirocin obtained by the deprotonation of the carboxy group; major microspecies at pH 7.3." [] subset: 3_STAR is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:7025 ! mupirocin [Term] id: CHEBI:146260 name: spectinomycin(1+) namespace: chebi_ontology def: "A secondary ammonium ion derived from spectinomycin by protonation of the secondary amino group located between the two alcoholic hydroxy groups." [] subset: 3_STAR synonym: "spectinomycin" RELATED [UniProt] is_a: CHEBI:137419 ! secondary ammonium ion relationship: is_conjugate_acid_of CHEBI:9215 ! spectinomycin relationship: is_conjugate_base_of CHEBI:77315 ! spectinomycin(2+) [Term] id: CHEBI:146295 name: pyranobenzodioxin namespace: chebi_ontology def: "Any organic heterotricyclic compound whose core skeleton consists of a benzodioxin ring that is ortho-fused to a pyran ring." [] subset: 3_STAR synonym: "pyranobenzodioxins" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:149552 name: emetic namespace: chebi_ontology def: "Any agent that induces nausea and vomiting." [] subset: 3_STAR synonym: "emetics" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:149553 name: anticoronaviral agent namespace: chebi_ontology def: "Any antiviral agent which inhibits the activity of coronaviruses." [] subset: 3_STAR synonym: "anti-coronaviral agent" RELATED [ChEBI] synonym: "anti-coronaviral agents" RELATED [ChEBI] synonym: "anti-coronavirus agent" RELATED [ChEBI] synonym: "anti-coronavirus agents" RELATED [ChEBI] synonym: "anticoronaviral agent" EXACT [ChEBI] synonym: "anticoronaviral agents" RELATED [ChEBI] synonym: "anticoronaviral drug" RELATED [ChEBI] synonym: "anticoronaviral drugs" RELATED [ChEBI] synonym: "anticoronavirus agent" RELATED [ChEBI] synonym: "anticoronavirus agents" RELATED [ChEBI] synonym: "anticoronviral agent" RELATED [ChEBI] synonym: "anticoronviral agents" RELATED [ChEBI] xref: Wikipedia:Coronavirus is_a: CHEBI:22587 ! antiviral agent [Term] id: CHEBI:149836 name: tigecycline namespace: chebi_ontology alt_id: CHEBI:29696 alt_id: CHEBI:473970 def: "Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms." [] subset: 3_STAR synonym: "(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide" RELATED [ChemIDplus] xref: DrugBank:DB00560 xref: KEGG:C12012 xref: KEGG:D01079 is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines relationship: is_conjugate_base_of CHEBI:142708 ! tigecycline(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:15022 name: electron donor namespace: chebi_ontology def: "A molecular entity that can transfer an electron to another molecular entity." [] subset: 3_STAR synonym: "donneur d'electron" RELATED [IUPAC] synonym: "Elektronendonator" RELATED [ChEBI] is_a: CHEBI:17891 ! donor [Term] id: CHEBI:15138 name: sulfide(2-) namespace: chebi_ontology def: "A divalent inorganic anion obtained by removal of both protons from hydrogen sulfide." [] subset: 3_STAR synonym: "S(2-)" RELATED [IUPAC] synonym: "Sulfide" RELATED [ChemIDplus] synonym: "sulphide" RELATED [ChEBI] is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:29919 ! hydrosulfide [Term] id: CHEBI:15339 name: acceptor namespace: chebi_ontology alt_id: CHEBI:13699 alt_id: CHEBI:2377 def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." [] subset: 3_STAR synonym: "A" RELATED [KEGG_COMPOUND] synonym: "accepteur" RELATED [ChEBI] synonym: "Acceptor" EXACT [KEGG_COMPOUND] synonym: "Akzeptor" RELATED [ChEBI] synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND] synonym: "Oxidized donor" RELATED [KEGG_COMPOUND] xref: KEGG:C00028 xref: KEGG:C16722 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:15354 name: choline namespace: chebi_ontology alt_id: CHEBI:13985 alt_id: CHEBI:23212 alt_id: CHEBI:3665 alt_id: CHEBI:41524 def: "A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function." [] subset: 3_STAR synonym: "Bilineurine" RELATED [KEGG_COMPOUND] synonym: "Choline" EXACT [KEGG_COMPOUND] synonym: "choline" EXACT [UniProt] synonym: "CHOLINE ION" RELATED [PDBeChem] synonym: "N,N,N-trimethylethanol-ammonium" RELATED [ChEBI] synonym: "N-trimethylethanolamine" RELATED [ChEBI] synonym: "trimethylethanolamine" RELATED [ChEBI] xref: DrugBank:DB00122 xref: ECMDB:ECMDB00097 xref: HMDB:HMDB0000097 xref: KEGG:C00114 xref: KEGG:D07690 xref: KNApSAcK:C00007298 xref: MetaCyc:CHOLINE xref: PDBeChem:CHT xref: Wikipedia:Choline xref: YMDB:YMDB00227 is_a: CHEBI:23217 ! cholines relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter relationship: RO:0000087 CHEBI:33284 ! has role nutrient relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite [Term] id: CHEBI:15366 name: acetic acid namespace: chebi_ontology alt_id: CHEBI:22169 alt_id: CHEBI:2387 alt_id: CHEBI:40486 def: "A simple monocarboxylic acid containing two carbons." [] subset: 3_STAR synonym: "ACETIC ACID" EXACT [PDBeChem] synonym: "Acetic acid" EXACT [KEGG_COMPOUND] synonym: "acide acetique" RELATED [ChemIDplus] synonym: "AcOH" RELATED [ChEBI] synonym: "CH3-COOH" RELATED [IUPAC] synonym: "CH3CO2H" RELATED [ChEBI] synonym: "E 260" RELATED [ChEBI] synonym: "E-260" RELATED [ChEBI] synonym: "E260" RELATED [ChEBI] synonym: "Essigsaeure" RELATED [ChEBI] synonym: "Ethanoic acid" RELATED [KEGG_COMPOUND] synonym: "ethoic acid" RELATED [ChEBI] synonym: "Ethylic acid" RELATED [ChemIDplus] synonym: "HOAc" RELATED [ChEBI] synonym: "INS No. 260" RELATED [ChEBI] synonym: "MeCO2H" RELATED [ChEBI] synonym: "MeCOOH" RELATED [ChEBI] synonym: "Methanecarboxylic acid" RELATED [ChemIDplus] xref: HMDB:HMDB0000042 xref: KEGG:C00033 xref: KEGG:D00010 xref: KNApSAcK:C00001176 xref: MetaCyc:ACET xref: PDBeChem:ACT xref: PDBeChem:ACY xref: PPDB:1333 xref: Wikipedia:Acetic_acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:30089 ! acetate relationship: RO:0000087 CHEBI:48356 ! has role protic solvent relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite [Term] id: CHEBI:15369 name: actinomycin namespace: chebi_ontology alt_id: CHEBI:13723 alt_id: CHEBI:22220 alt_id: CHEBI:2445 def: "A large group of antibiotics isolated from various species of Streptomyces and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides." [] subset: 3_STAR synonym: "Actinomycin" EXACT [KEGG_COMPOUND] synonym: "actinomycins" RELATED [ChEBI] xref: KEGG:C01775 is_a: CHEBI:23239 ! chromopeptide [Term] id: CHEBI:15693 name: aldose namespace: chebi_ontology alt_id: CHEBI:13755 alt_id: CHEBI:22305 alt_id: CHEBI:2561 def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." [] subset: 3_STAR synonym: "Aldose" EXACT [KEGG_COMPOUND] synonym: "aldoses" RELATED [ChEBI] synonym: "an aldose" RELATED [UniProt] xref: KEGG:C01370 xref: Wikipedia:Aldose is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:15705 name: L-alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:13072 alt_id: CHEBI:13243 alt_id: CHEBI:13797 alt_id: CHEBI:21224 alt_id: CHEBI:6175 def: "Any alpha-amino acid having L-configuration at the alpha-carbon." [] subset: 3_STAR synonym: "L-2-Amino acid" RELATED [KEGG_COMPOUND] synonym: "L-alpha-amino acid" EXACT [IUPAC] synonym: "L-alpha-amino acids" RELATED [ChEBI] synonym: "L-Amino acid" RELATED [KEGG_COMPOUND] xref: KEGG:C00151 is_a: CHEBI:33704 ! alpha-amino acid relationship: is_conjugate_acid_of CHEBI:59814 ! L-alpha-amino acid anion relationship: is_tautomer_of CHEBI:59869 ! L-alpha-amino acid zwitterion [Term] id: CHEBI:15734 name: primary alcohol namespace: chebi_ontology alt_id: CHEBI:13676 alt_id: CHEBI:14887 alt_id: CHEBI:26262 alt_id: CHEBI:57489 alt_id: CHEBI:8406 def: "A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [] subset: 3_STAR synonym: "1-Alcohol" RELATED [KEGG_COMPOUND] synonym: "a primary alcohol" RELATED [UniProt] synonym: "Primary alcohol" EXACT [KEGG_COMPOUND] synonym: "primary alcohols" RELATED [ChEBI] xref: KEGG:C00226 is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:15740 name: formate namespace: chebi_ontology alt_id: CHEBI:14276 alt_id: CHEBI:24081 def: "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." [] subset: 3_STAR synonym: "aminate" RELATED [ChEBI] synonym: "formate" EXACT [UniProt] synonym: "formiate" RELATED [ChEBI] synonym: "formic acid, ion(1-)" RELATED [ChemIDplus] synonym: "formylate" RELATED [ChEBI] synonym: "HCO2 anion" RELATED [NIST_Chemistry_WebBook] synonym: "hydrogen carboxylate" RELATED [ChEBI] synonym: "methanoate" RELATED [ChEBI] xref: HMDB:HMDB0000142 xref: KEGG:C00058 xref: MetaCyc:FORMATE xref: Wikipedia:Formate is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:30751 ! formic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:15841 name: polypeptide namespace: chebi_ontology alt_id: CHEBI:14860 alt_id: CHEBI:8314 def: "A peptide containing ten or more amino acid residues." [] subset: 3_STAR synonym: "polipeptido" RELATED [ChEBI] synonym: "Polypeptid" RELATED [ChEBI] synonym: "Polypeptide" EXACT [KEGG_COMPOUND] xref: KEGG:C00403 is_a: CHEBI:16670 ! peptide is_a: CHEBI:33839 ! macromolecule [Term] id: CHEBI:15940 name: nicotinic acid namespace: chebi_ontology alt_id: CHEBI:25538 alt_id: CHEBI:44319 alt_id: CHEBI:7559 def: "A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group." [] subset: 3_STAR synonym: "3-carboxylpyridine" RELATED [ChemIDplus] synonym: "3-carboxypyridine" RELATED [NIST_Chemistry_WebBook] synonym: "3-pyridinecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "3-Pyridylcarboxylic acid" RELATED [HMDB] synonym: "anti-pellagra vitamin" RELATED [NIST_Chemistry_WebBook] synonym: "beta-pyridinecarboxylic acid" RELATED [ChEBI] synonym: "m-pyridinecarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Niacin" RELATED [KEGG_COMPOUND] synonym: "NICOTINIC ACID" EXACT [PDBeChem] synonym: "Nicotinic acid" EXACT [KEGG_COMPOUND] synonym: "Nicotinsaure" RELATED [ChemIDplus] synonym: "Nikotinsaeure" RELATED [ChEBI] synonym: "P.P. factor" RELATED [NIST_Chemistry_WebBook] synonym: "pellagra preventive factor" RELATED [NIST_Chemistry_WebBook] synonym: "PP factor" RELATED [NIST_Chemistry_WebBook] synonym: "pyridine-beta-carboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "pyridine-carboxylique-3" RELATED [ChemIDplus] synonym: "vitamin B3" RELATED [ChEBI] xref: Chemspider:913 xref: DrugBank:DB00627 xref: FooDB:FDB001014 xref: HMDB:HMDB0001488 xref: KEGG:C00253 xref: KEGG:D00049 xref: KNApSAcK:C00000208 xref: LINCS:LSM-4676 xref: MetaCyc:NIACINE xref: PDBeChem:NIO xref: Wikipedia:Niacin is_a: CHEBI:176839 ! vitamin B3 is_a: CHEBI:26416 ! pyridine alkaloid is_a: CHEBI:26420 ! pyridinemonocarboxylic acid relationship: is_conjugate_acid_of CHEBI:32544 ! nicotinate relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:35679 ! has role antilipemic drug relationship: RO:0000087 CHEBI:50247 ! has role antidote relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite relationship: RO:0000087 CHEBI:84264 ! has role EC 3.5.1.19 (nicotinamidase) inhibitor [Term] id: CHEBI:15986 name: polynucleotide namespace: chebi_ontology alt_id: CHEBI:13672 alt_id: CHEBI:14859 alt_id: CHEBI:8312 def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." [] subset: 3_STAR synonym: "Polynucleotide" EXACT [KEGG_COMPOUND] synonym: "polynucleotides" RELATED [ChEBI] xref: KEGG:C00419 is_a: CHEBI:33695 ! information biomacromolecule is_a: CHEBI:61120 ! nucleobase-containing molecular entity relationship: BFO:0000051 CHEBI:50319 ! has part nucleotide residue [Term] id: CHEBI:16040 name: cytosine namespace: chebi_ontology alt_id: CHEBI:14066 alt_id: CHEBI:23531 alt_id: CHEBI:4072 alt_id: CHEBI:41732 def: "An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4." [] subset: 3_STAR synonym: "4-amino-2(1H)-pyrimidinone" RELATED [NIST_Chemistry_WebBook] synonym: "4-amino-2-hydroxypyrimidine" RELATED [NIST_Chemistry_WebBook] synonym: "C" RELATED [ChEBI] synonym: "Cyt" RELATED [CBN] synonym: "Cytosin" RELATED [ChEBI] synonym: "Cytosine" EXACT [KEGG_COMPOUND] synonym: "cytosine" EXACT [UniProt] synonym: "Zytosin" RELATED [ChEBI] xref: HMDB:HMDB0000630 xref: KEGG:C00380 xref: KNApSAcK:C00001498 xref: MetaCyc:CYTOSINE xref: PDBeChem:CYT xref: Wikipedia:Cytosine is_a: CHEBI:26432 ! pyrimidine nucleobase is_a: CHEBI:38337 ! pyrimidone is_a: CHEBI:38338 ! aminopyrimidine relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:16042 name: halide anion namespace: chebi_ontology alt_id: CHEBI:14384 alt_id: CHEBI:5605 def: "A monoatomic monoanion resulting from the addition of an electron to any halogen atom." [] subset: 3_STAR synonym: "a halide anion" RELATED [UniProt] synonym: "Halide" RELATED [KEGG_COMPOUND] synonym: "halide anions" RELATED [ChEBI] synonym: "halide(1-)" RELATED [ChEBI] synonym: "halides" RELATED [ChEBI] synonym: "halogen anion" RELATED [ChEBI] synonym: "HX" RELATED [KEGG_COMPOUND] xref: KEGG:C00462 is_a: CHEBI:33429 ! monoatomic monoanion is_a: CHEBI:79389 ! monovalent inorganic anion [Term] id: CHEBI:16134 name: ammonia namespace: chebi_ontology alt_id: CHEBI:13405 alt_id: CHEBI:13406 alt_id: CHEBI:13407 alt_id: CHEBI:13771 alt_id: CHEBI:22533 alt_id: CHEBI:44269 alt_id: CHEBI:44284 alt_id: CHEBI:44404 alt_id: CHEBI:7434 def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." [] subset: 3_STAR synonym: "[NH3]" RELATED [MolBase] synonym: "AMMONIA" EXACT [PDBeChem] synonym: "Ammonia" EXACT [KEGG_COMPOUND] synonym: "ammoniac" RELATED [ChEBI] synonym: "Ammoniak" RELATED [ChemIDplus] synonym: "amoniaco" RELATED [ChEBI] synonym: "NH3" RELATED [IUPAC, KEGG_COMPOUND] synonym: "R-717" RELATED [ChEBI] synonym: "spirit of hartshorn" RELATED [ChemIDplus] xref: HMDB:HMDB0000051 xref: KEGG:C00014 xref: KEGG:D02916 xref: KNApSAcK:C00007267 xref: MetaCyc:AMMONIA xref: MolBase:930 xref: PDBeChem:NH3 xref: Wikipedia:Ammonia is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:35107 ! azane is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:29337 ! azanide relationship: is_conjugate_base_of CHEBI:28938 ! ammonium relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor relationship: RO:0000087 CHEBI:78433 ! has role refrigerant [Term] id: CHEBI:16136 name: hydrogen sulfide namespace: chebi_ontology alt_id: CHEBI:13356 alt_id: CHEBI:14414 alt_id: CHEBI:24639 alt_id: CHEBI:43058 alt_id: CHEBI:45489 alt_id: CHEBI:5787 def: "A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen." [] subset: 3_STAR synonym: "[SH2]" RELATED [MolBase] synonym: "acide sulfhydrique" RELATED [ChemIDplus] synonym: "dihydrogen monosulfide" RELATED [NIST_Chemistry_WebBook] synonym: "dihydrogen sulfide" RELATED [NIST_Chemistry_WebBook] synonym: "H2S" RELATED [IUPAC, KEGG_COMPOUND] synonym: "hydrogen monosulfide" RELATED [NIST_Chemistry_WebBook] synonym: "Hydrogen sulfide" EXACT [KEGG_COMPOUND] synonym: "hydrogen sulphide" RELATED [ChemIDplus] synonym: "Hydrogen-sulfide" RELATED [KEGG_COMPOUND] synonym: "hydrogene sulfure" RELATED [ChemIDplus] synonym: "HYDROSULFURIC ACID" RELATED [PDBeChem] synonym: "Schwefelwasserstoff" RELATED [ChemIDplus] synonym: "Sulfide" RELATED [KEGG_COMPOUND] synonym: "sulfure d'hydrogene" RELATED [ChEBI] xref: KEGG:C00283 xref: KNApSAcK:C00007266 xref: MolBase:1709 xref: PDBeChem:H2S xref: Wikipedia:Hydrogen_sulfide is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:33405 ! hydracid is_a: CHEBI:33535 ! sulfur hydride is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:29919 ! hydrosulfide relationship: is_conjugate_base_of CHEBI:30488 ! sulfonium relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:50902 ! has role genotoxin relationship: RO:0000087 CHEBI:62488 ! has role signalling molecule relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:16150 name: benzoate namespace: chebi_ontology alt_id: CHEBI:13879 alt_id: CHEBI:22717 def: "The simplest member of the class of benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1." [] subset: 3_STAR synonym: "Benzenecarboxylate" RELATED [HMDB] synonym: "Benzeneformate" RELATED [HMDB] synonym: "Benzenemethanoate" RELATED [HMDB] synonym: "benzoate" EXACT [UniProt] synonym: "benzoate anion" RELATED [NIST_Chemistry_WebBook] synonym: "benzoic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Phenylcarboxylate" RELATED [HMDB] synonym: "Phenylformate" RELATED [HMDB] xref: HMDB:HMDB0001870 xref: KEGG:C00180 xref: MetaCyc:BENZOATE is_a: CHEBI:22718 ! benzoates relationship: is_conjugate_base_of CHEBI:30746 ! benzoic acid relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite [Term] id: CHEBI:161680 name: aztreonam namespace: chebi_ontology alt_id: CHEBI:2960 alt_id: CHEBI:41008 def: "A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking." [] subset: 3_STAR synonym: "(Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid" RELATED [ChemIDplus] synonym: "AZT" RELATED [ChEBI] xref: DrugBank:DB00355 xref: KEGG:C06840 xref: KEGG:D00240 xref: Patent:NL8100571 xref: PDBeChem:AZR xref: Wikipedia:Aztreonam is_a: CHEBI:50695 ! monobactam is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50696 ! has role EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:16189 name: sulfate namespace: chebi_ontology alt_id: CHEBI:15135 alt_id: CHEBI:45687 alt_id: CHEBI:9335 def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." [] subset: 3_STAR synonym: "[SO4](2-)" RELATED [IUPAC] synonym: "SO4(2-)" RELATED [IUPAC] synonym: "Sulfate" EXACT [KEGG_COMPOUND] synonym: "sulfate" EXACT [UniProt] synonym: "Sulfate anion(2-)" RELATED [HMDB] synonym: "Sulfate dianion" RELATED [HMDB] synonym: "SULFATE ION" RELATED [PDBeChem] synonym: "Sulfate(2-)" RELATED [HMDB] synonym: "Sulfuric acid ion(2-)" RELATED [HMDB] synonym: "sulphate" RELATED [ChEBI] synonym: "sulphate ion" RELATED [ChEBI] xref: HMDB:HMDB0001448 xref: KEGG:C00059 xref: KEGG:D05963 xref: MetaCyc:SULFATE xref: PDBeChem:SO4 xref: Wikipedia:Sulfate is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:16199 name: urea namespace: chebi_ontology alt_id: CHEBI:15292 alt_id: CHEBI:27218 alt_id: CHEBI:46379 alt_id: CHEBI:9888 def: "A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O)." [] subset: 3_STAR synonym: "1728" RELATED [PPDB] synonym: "Carbamide" RELATED [KEGG_COMPOUND] synonym: "carbonyldiamide" RELATED [NIST_Chemistry_WebBook] synonym: "E927b" RELATED [ChEBI] synonym: "H2NC(O)NH2" RELATED [ChEBI] synonym: "Harnstoff" RELATED [NIST_Chemistry_WebBook] synonym: "Karbamid" RELATED [ChEBI] synonym: "ur" RELATED [IUPAC] synonym: "UREA" EXACT [PDBeChem] synonym: "Urea" EXACT [KEGG_COMPOUND] synonym: "urea" EXACT [UniProt] synonym: "uree" RELATED [ChEBI] xref: DrugBank:DB03904 xref: ECMDB:ECMDB04172 xref: HMDB:HMDB0000294 xref: KEGG:C00086 xref: KEGG:D00023 xref: KNApSAcK:C00007314 xref: MetaCyc:UREA xref: PDBeChem:URE xref: PPDB:1728 xref: Wikipedia:Urea xref: YMDB:YMDB00003 is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:64708 ! one-carbon compound relationship: has_functional_parent CHEBI:28976 ! carbonic acid relationship: is_tautomer_of CHEBI:48376 ! carbamimidic acid relationship: RO:0000087 CHEBI:33287 ! has role fertilizer relationship: RO:0000087 CHEBI:64577 ! has role flour treatment agent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite [Term] id: CHEBI:16215 name: phosphonate(2-) namespace: chebi_ontology alt_id: CHEBI:14820 alt_id: CHEBI:39856 alt_id: CHEBI:8154 def: "A divalent inorganic anion obtained by removal of both protons from phosphonic acid" [] subset: 3_STAR synonym: "[PHO3](2-)" RELATED [IUPAC] synonym: "PHO3(2-)" RELATED [IUPAC] synonym: "PHOSPHONATE" RELATED [PDBeChem] synonym: "Phosphonate" RELATED [KEGG_COMPOUND] synonym: "phosphonate" RELATED [IUPAC, UniProt] xref: KEGG:C06701 xref: MetaCyc:PHOSPHONATE xref: PDBeChem:2PO is_a: CHEBI:33461 ! phosphorus oxoanion is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:33462 ! phosphonate(1-) [Term] id: CHEBI:16240 name: hydrogen peroxide namespace: chebi_ontology alt_id: CHEBI:13354 alt_id: CHEBI:13355 alt_id: CHEBI:24637 alt_id: CHEBI:44812 alt_id: CHEBI:5586 def: "An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond." [] subset: 3_STAR synonym: "[OH(OH)]" RELATED [MolBase] synonym: "dihydrogen dioxide" RELATED [IUPAC] synonym: "H2O2" RELATED [KEGG_COMPOUND, UniProt] synonym: "HOOH" RELATED [IUPAC] synonym: "HYDROGEN PEROXIDE" EXACT [PDBeChem] synonym: "Hydrogen peroxide" EXACT [KEGG_COMPOUND] synonym: "Oxydol" RELATED [KEGG_COMPOUND] synonym: "perhydrol" RELATED [MetaCyc] xref: HMDB:HMDB0003125 xref: KEGG:C00027 xref: KEGG:D00008 xref: MetaCyc:HYDROGEN-PEROXIDE xref: MolBase:932 xref: PDBeChem:PEO xref: PPDB:387 xref: Wikipedia:Hydrogen_peroxide is_a: CHEBI:24837 ! inorganic peroxide is_a: CHEBI:26523 ! reactive oxygen species relationship: is_conjugate_acid_of CHEBI:29192 ! hydrogenperoxide(1-) relationship: RO:0000087 CHEBI:132717 ! has role bleaching agent relationship: RO:0000087 CHEBI:149552 ! has role emetic relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:48219 ! has role disinfectant relationship: RO:0000087 CHEBI:50902 ! has role genotoxin relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:59163 ! has role biomarker relationship: RO:0000087 CHEBI:63490 ! has role explosive relationship: RO:0000087 CHEBI:65259 ! has role GABA antagonist relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:16247 name: phospholipid namespace: chebi_ontology alt_id: CHEBI:14816 alt_id: CHEBI:26063 alt_id: CHEBI:8150 def: "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." [] subset: 3_STAR synonym: "a phospholipid derivative" RELATED [UniProt] synonym: "Phospholipid" EXACT [KEGG_COMPOUND] synonym: "phospholipids" RELATED [ChEBI] xref: KEGG:C00865 is_a: CHEBI:18059 ! lipid is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester relationship: is_conjugate_acid_of CHEBI:62643 ! anionic phospholipid [Term] id: CHEBI:16313 name: D-proline namespace: chebi_ontology alt_id: CHEBI:13008 alt_id: CHEBI:21070 alt_id: CHEBI:42012 alt_id: CHEBI:42129 alt_id: CHEBI:42213 alt_id: CHEBI:4226 alt_id: CHEBI:45156 def: "The D-enantiomer of proline." [] subset: 3_STAR synonym: "(2R)-pyrrolidine-2-carboxylic acid" RELATED [IUPAC] synonym: "(R)-2-Carboxypyrrolidine" RELATED [HMDB] synonym: "(R)-pyrrolidine-2-carboxylic acid" RELATED [ChEBI] synonym: "D-Prolin" RELATED [ChEBI] synonym: "D-PROLINE" EXACT [PDBeChem] synonym: "D-Proline" EXACT [KEGG_COMPOUND] synonym: "DPR" RELATED [PDBeChem] xref: DrugBank:DB02853 xref: HMDB:HMDB0003411 xref: KEGG:C00763 xref: MetaCyc:D-PROLINE xref: PDBeChem:DPR xref: Wikipedia:D-proline is_a: CHEBI:16733 ! D-alpha-amino acid is_a: CHEBI:26271 ! proline relationship: is_conjugate_acid_of CHEBI:32867 ! D-prolinate relationship: is_conjugate_base_of CHEBI:32868 ! D-prolinium relationship: is_enantiomer_of CHEBI:17203 ! L-proline relationship: is_tautomer_of CHEBI:57726 ! D-proline zwitterion relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite [Term] id: CHEBI:16385 name: organic sulfide namespace: chebi_ontology alt_id: CHEBI:13694 alt_id: CHEBI:26960 alt_id: CHEBI:9340 def: "Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers." [] subset: 3_STAR synonym: "organic sulfides" RELATED [ChEBI] synonym: "RSR" RELATED [IUPAC] synonym: "Sulfide" RELATED [KEGG_COMPOUND] synonym: "Thioether" RELATED [KEGG_COMPOUND] synonym: "thioethers" RELATED [IUPAC] xref: KEGG:C00297 is_a: CHEBI:26822 ! sulfide is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:164200 name: triclosan namespace: chebi_ontology alt_id: CHEBI:29697 alt_id: CHEBI:47700 def: "An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes." [] subset: 3_STAR synonym: "2,4,4'-Trichloro-2'-hydroxydiphenyl ether" RELATED [ChemIDplus] synonym: "5-Chloro-2-(2,4-dichloro-phenoxy)-phenol" RELATED [ChEMBL] synonym: "Triclosan" EXACT [KEGG_COMPOUND] xref: DrugBank:DB08604 xref: KEGG:C12059 xref: KEGG:D06226 xref: LINCS:LSM-2929 xref: Patent:NL6401526 xref: Patent:US3506720 xref: Patent:US3629477 xref: PDBeChem:TCL xref: Wikipedia:Triclosan is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:33853 ! phenols is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:83403 ! monochlorobenzenes relationship: RO:0000087 CHEBI:139512 ! has role EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor relationship: RO:0000087 CHEBI:24127 ! has role fungicide relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:38068 ! has role antimalarial relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor relationship: RO:0000087 CHEBI:77853 ! has role persistent organic pollutant relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:16541 name: protein polypeptide chain namespace: chebi_ontology alt_id: CHEBI:8526 def: "A naturally occurring polypeptide synthesized at the ribosome." [] subset: 3_STAR synonym: "a protein" RELATED [UniProt] synonym: "polypeptide chain" RELATED [ChEBI] synonym: "Protein" RELATED [KEGG_COMPOUND] synonym: "protein polypeptide chains" RELATED [ChEBI] xref: KEGG:C00017 is_a: CHEBI:15841 ! polypeptide relationship: BFO:0000051 CHEBI:33700 ! has part proteinogenic amino-acid residue [Term] id: CHEBI:16646 name: carbohydrate namespace: chebi_ontology alt_id: CHEBI:15131 alt_id: CHEBI:23008 alt_id: CHEBI:9318 def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." [] subset: 3_STAR synonym: "a carbohydrate" RELATED [UniProt] synonym: "carbohidrato" RELATED [IUPAC] synonym: "carbohidratos" RELATED [IUPAC] synonym: "glucide" RELATED [ChEBI] synonym: "glucides" RELATED [ChEBI] synonym: "glucido" RELATED [ChEBI] synonym: "glucidos" RELATED [ChEBI] synonym: "hydrates de carbone" RELATED [ChEBI] synonym: "Kohlenhydrat" RELATED [ChEBI] synonym: "Kohlenhydrate" RELATED [ChEBI] synonym: "saccharide" RELATED [IUPAC] synonym: "saccharides" RELATED [IUPAC] synonym: "saccharidum" RELATED [ChEBI] xref: Wikipedia:Carbohydrate is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16670 name: peptide namespace: chebi_ontology alt_id: CHEBI:14753 alt_id: CHEBI:25906 alt_id: CHEBI:7990 def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." [] subset: 3_STAR synonym: "Peptid" RELATED [ChEBI] synonym: "Peptide" EXACT [KEGG_COMPOUND] synonym: "peptido" RELATED [ChEBI] synonym: "peptidos" RELATED [ChEBI] xref: KEGG:C00012 is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:50047 ! organic amino compound relationship: BFO:0000051 CHEBI:33708 ! has part amino-acid residue relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion [Term] id: CHEBI:16704 name: uridine namespace: chebi_ontology alt_id: CHEBI:15296 alt_id: CHEBI:27227 alt_id: CHEBI:46386 alt_id: CHEBI:46391 alt_id: CHEBI:46460 alt_id: CHEBI:9893 def: "A ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N(1)-glycosidic bond." [] subset: 3_STAR synonym: "1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione" RELATED [ChEBI] synonym: "1-beta-D-ribofuranosyluracil" RELATED [HMDB] synonym: "beta-Uridine" RELATED [HMDB] synonym: "u" RELATED [ChEBI] synonym: "Urd" RELATED [CBN] synonym: "Uridin" RELATED [ChemIDplus] synonym: "URIDINE" EXACT [PDBeChem] synonym: "Uridine" EXACT [KEGG_COMPOUND] synonym: "uridine" EXACT [UniProt] xref: DrugBank:DB02745 xref: ECMDB:ECMDB00296 xref: HMDB:HMDB0000296 xref: KEGG:C00299 xref: KNApSAcK:C00019674 xref: MetaCyc:URIDINE xref: PDBeChem:URI xref: Wikipedia:Uridine xref: YMDB:YMDB00127 is_a: CHEBI:27242 ! uridines relationship: RO:0000087 CHEBI:49103 ! has role drug metabolite relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite [Term] id: CHEBI:16705 name: 6-aminopenicillanic acid namespace: chebi_ontology alt_id: CHEBI:20705 alt_id: CHEBI:2172 def: "A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics." [] subset: 3_STAR synonym: "(+)-6-aminopenicillanic acid" RELATED [ChEBI] synonym: "(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6-Aminopenicillamine acid" RELATED [ChemIDplus] synonym: "6-Aminopenicillanate" RELATED [KEGG_COMPOUND] synonym: "6-Aminopenicillanic acid" EXACT [KEGG_COMPOUND] synonym: "6-APA" RELATED [ChEBI] synonym: "6-Apa" RELATED [ChemIDplus] synonym: "6-Aps" RELATED [ChemIDplus] synonym: "6beta-aminopenicillanic acid" RELATED [ChEBI] synonym: "Aminopenicillanic acid" RELATED [ChemIDplus] synonym: "Penicin" RELATED [ChemIDplus] synonym: "Penin" RELATED [ChemIDplus] synonym: "Phenacyl 6-aminopenicillinate" RELATED [ChemIDplus] xref: KEGG:C02954 xref: Patent:US2941995 xref: PDBeChem:X1E xref: Wikipedia:6-APA is_a: CHEBI:25865 ! penicillanic acids relationship: has_functional_parent CHEBI:37806 ! penicillanic acid relationship: is_conjugate_acid_of CHEBI:30938 ! 6-aminopenicillanate relationship: is_tautomer_of CHEBI:57869 ! 6-aminopenicillanic acid zwitterion relationship: RO:0000087 CHEBI:50904 ! has role allergen [Term] id: CHEBI:16716 name: benzene namespace: chebi_ontology alt_id: CHEBI:13876 alt_id: CHEBI:22703 alt_id: CHEBI:3025 alt_id: CHEBI:41187 def: "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." [] subset: 3_STAR synonym: "[6]annulene" RELATED [NIST_Chemistry_WebBook] synonym: "Benzen" RELATED [IUPAC] synonym: "BENZENE" EXACT [PDBeChem] synonym: "Benzene" EXACT [KEGG_COMPOUND] synonym: "benzene" EXACT [ChEBI, UniProt] synonym: "Benzine" RELATED [UM-BBD] synonym: "Benzol" RELATED [ChemIDplus] synonym: "benzole" RELATED [NIST_Chemistry_WebBook] synonym: "Bicarburet of hydrogen" RELATED [ChemIDplus] synonym: "Coal naphtha" RELATED [ChemIDplus] synonym: "cyclohexatriene" RELATED [UM-BBD] synonym: "Mineral naphtha" RELATED [ChemIDplus] synonym: "Phene" RELATED [ChemIDplus] synonym: "phenyl hydride" RELATED [UM-BBD] synonym: "Pyrobenzol" RELATED [ChemIDplus] synonym: "Pyrobenzole" RELATED [ChemIDplus] xref: HMDB:HMDB0001505 xref: KEGG:C01407 xref: PDBeChem:BNZ xref: Wikipedia:Benzene is_a: CHEBI:134179 ! volatile organic compound is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33842 ! aromatic annulene relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:167164 name: mineral nutrient namespace: chebi_ontology def: "A mineral that is an inorganic nutrient which must be ingested and absorbed in adequate amounts to satisfy a wide range of essential metabolic and/or structural functions in the human body." [] subset: 3_STAR synonym: "mineral nutrient" EXACT [ChEBI] synonym: "mineral nutrients" RELATED [ChEBI] synonym: "nutrient mineral" RELATED [ChEBI] synonym: "nutrient minerals" RELATED [ChEBI] xref: Wikipedia:Mineral_(nutrient) is_a: CHEBI:46662 ! mineral relationship: RO:0000087 CHEBI:33284 ! has role nutrient [Term] id: CHEBI:167183 name: piscicide namespace: chebi_ontology def: "A substance which is poisonous to fish and is primarily used to eliminate dominant species of fish in water." [] subset: 3_STAR synonym: "piscicides" RELATED [ChEBI] xref: Wikipedia:Piscicide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:16733 name: D-alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:12909 alt_id: CHEBI:13625 alt_id: CHEBI:20906 alt_id: CHEBI:4097 subset: 3_STAR synonym: "D-alpha-amino acid" EXACT [ChEBI] synonym: "D-alpha-amino acids" RELATED [ChEBI] synonym: "D-Amino acid" RELATED [KEGG_COMPOUND] xref: KEGG:C00405 is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid relationship: is_conjugate_acid_of CHEBI:60895 ! D-alpha-amino acid anion relationship: is_tautomer_of CHEBI:59871 ! D-alpha-amino acid zwitterion [Term] id: CHEBI:167559 name: glycan namespace: chebi_ontology def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." [] subset: 3_STAR synonym: "glycans" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives [Term] id: CHEBI:16914 name: salicylic acid namespace: chebi_ontology alt_id: CHEBI:26597 alt_id: CHEBI:45521 alt_id: CHEBI:9006 def: "A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves." [] subset: 3_STAR synonym: "2-carboxyphenol" RELATED [NIST_Chemistry_WebBook] synonym: "2-HYDROXYBENZOIC ACID" RELATED [PDBeChem] synonym: "o-carboxyphenol" RELATED [NIST_Chemistry_WebBook] synonym: "o-Hydroxybenzoic acid" RELATED [KEGG_COMPOUND] synonym: "o-hydroxybenzoic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Salicylic acid" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00936 xref: HMDB:HMDB0001895 xref: KEGG:C00805 xref: KEGG:D00097 xref: KNApSAcK:C00000206 xref: LINCS:LSM-4763 xref: MetaCyc:CPD-110 xref: PDBeChem:SAL xref: Wikipedia:Salicylic_Acid is_a: CHEBI:25389 ! monohydroxybenzoic acid relationship: is_conjugate_acid_of CHEBI:30762 ! salicylate relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:37848 ! has role plant hormone relationship: RO:0000087 CHEBI:50176 ! has role keratolytic drug relationship: RO:0000087 CHEBI:73181 ! has role EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite [Term] id: CHEBI:16976 name: hygromycin B namespace: chebi_ontology alt_id: CHEBI:14426 alt_id: CHEBI:24752 alt_id: CHEBI:43202 alt_id: CHEBI:5821 subset: 3_STAR synonym: "Antibiotic A-396-II" RELATED [KEGG_COMPOUND] synonym: "HYGROMYCIN B" EXACT [PDBeChem] synonym: "Hygromycin B" EXACT [KEGG_COMPOUND] synonym: "O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N(3)-methyl-D-streptamine" RELATED [ChEBI] xref: KEGG:C01925 xref: PDBeChem:HYG is_a: CHEBI:24753 ! hygromycin is_a: CHEBI:71989 ! ortho ester relationship: is_conjugate_base_of CHEBI:57971 ! hygromycin B(3+) relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug [Term] id: CHEBI:17029 name: chitin namespace: chebi_ontology alt_id: CHEBI:13962 alt_id: CHEBI:23099 alt_id: CHEBI:3596 def: "An aminoglycan consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [] subset: 3_STAR synonym: "[1,4-(N-Acetyl-beta-D-glucosaminyl)]n" RELATED [KEGG_COMPOUND] synonym: "[4)-beta-D-GlcpNAc(1->]n" RELATED [IUPAC] synonym: "beta-1,4-Poly-N-acetyl-D-glucosamine" RELATED [KEGG_COMPOUND] synonym: "Chitin" EXACT [KEGG_COMPOUND] synonym: "chitin" EXACT [IUPAC, UniProt] xref: KEGG:C00461 xref: KEGG:G10483 is_a: CHEBI:21638 ! N-acylglucosamine is_a: CHEBI:22506 ! aminoglycan relationship: RO:0000087 CHEBI:73336 ! has role vulnerary relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17076 name: streptomycin namespace: chebi_ontology alt_id: CHEBI:15119 alt_id: CHEBI:26784 alt_id: CHEBI:45745 alt_id: CHEBI:9284 def: "A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class" [] subset: 3_STAR synonym: "2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside" RELATED [ChemIDplus] synonym: "[2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}" RELATED [IUPAC] synonym: "SM" RELATED [KEGG_DRUG] synonym: "streomycin" RELATED [ChEBI] synonym: "STREPTOMYCIN" EXACT [PDBeChem] xref: DrugBank:DB01082 xref: HMDB:HMDB0015214 xref: KEGG:C00413 xref: KEGG:D08531 xref: MetaCyc:STREPTOMYCIN xref: PDBeChem:SRY xref: Wikipedia:Streptomycin is_a: CHEBI:26788 ! streptomycins is_a: CHEBI:87113 ! antibiotic antifungal drug is_a: CHEBI:87114 ! antibiotic fungicide relationship: has_functional_parent CHEBI:27405 ! streptidine relationship: is_conjugate_base_of CHEBI:58007 ! streptomycin(3+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:17087 name: ketone namespace: chebi_ontology alt_id: CHEBI:13427 alt_id: CHEBI:13646 alt_id: CHEBI:24974 alt_id: CHEBI:6127 alt_id: CHEBI:8742 def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." [] subset: 3_STAR synonym: "a ketone" RELATED [UniProt] synonym: "cetone" RELATED [ChEBI] synonym: "Keton" RELATED [ChEBI] synonym: "Ketone" EXACT [KEGG_COMPOUND] synonym: "ketones" RELATED [ChEBI] synonym: "R-CO-R'" RELATED [KEGG_COMPOUND] xref: KEGG:C01450 xref: Wikipedia:Ketone is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:17137 name: hydrogensulfite namespace: chebi_ontology alt_id: CHEBI:13367 alt_id: CHEBI:5598 subset: 3_STAR synonym: "[SO2(OH)](-)" RELATED [IUPAC] synonym: "Bisulfite" RELATED [KEGG_COMPOUND] synonym: "bisulfite" RELATED [ChemIDplus] synonym: "bisulphite" RELATED [ChemIDplus] synonym: "HSO3(-)" RELATED [IUPAC] synonym: "HSO3-" RELATED [KEGG_COMPOUND] synonym: "Hydrogen sulfite" RELATED [KEGG_COMPOUND] synonym: "hydrogen sulfite(1-)" RELATED [ChemIDplus] synonym: "hydrosulfite anion" RELATED [ChemIDplus] xref: KEGG:C11481 xref: PDBeChem:SO3 is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_acid_of CHEBI:17359 ! sulfite relationship: is_conjugate_base_of CHEBI:48854 ! sulfurous acid relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17154 name: nicotinamide namespace: chebi_ontology alt_id: CHEBI:14645 alt_id: CHEBI:25521 alt_id: CHEBI:44258 alt_id: CHEBI:7556 def: "A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group." [] subset: 3_STAR synonym: "3-carbamoylpyridine" RELATED [ChemIDplus] synonym: "3-pyridinecarboxamide" RELATED [NIST_Chemistry_WebBook] synonym: "beta-pyridinecarboxamide" RELATED [ChemIDplus, NIST_Chemistry_WebBook] synonym: "m-(aminocarbonyl)pyridine" RELATED [ChemIDplus] synonym: "niacin" RELATED [ChEBI] synonym: "Niacinamide" RELATED [KEGG_COMPOUND] synonym: "niamide" RELATED [ChemIDplus] synonym: "Nicotinamid" RELATED [ChEBI] synonym: "nicotinamide" EXACT [UniProt] synonym: "nicotine acid amide" RELATED [ChemIDplus] synonym: "nicotine amide" RELATED [ChemIDplus] synonym: "nicotinic acid amide" RELATED [ChemIDplus] synonym: "nicotinic amide" RELATED [ChemIDplus] synonym: "Nicotinsaeureamid" RELATED [ChEBI] synonym: "nicotylamide" RELATED [ChemIDplus] synonym: "Nikotinamid" RELATED [ChemIDplus] synonym: "Nikotinsaeureamid" RELATED [ChEBI] synonym: "pyridine-3-carboxylic acid amide" RELATED [ChemIDplus] synonym: "vitamin B3" RELATED [ChemIDplus] synonym: "Vitamin PP" RELATED [KEGG_COMPOUND] xref: DrugBank:DB02701 xref: FooDB:FDB012485 xref: HMDB:HMDB0001406 xref: KEGG:C00153 xref: KEGG:D00036 xref: KNApSAcK:C00000209 xref: LINCS:LSM-5428 xref: MetaCyc:NIACINAMIDE xref: Patent:US2904552 xref: Patent:US2993051 xref: PDBeChem:NCA xref: Wikipedia:Nicotinamide is_a: CHEBI:176839 ! vitamin B3 is_a: CHEBI:25529 ! pyridinecarboxamide is_a: CHEBI:26416 ! pyridine alkaloid relationship: has_functional_parent CHEBI:15940 ! nicotinic acid relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:22586 ! has role antioxidant relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:62913 ! has role EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent relationship: RO:0000087 CHEBI:71181 ! has role Sir2 inhibitor relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite [Term] id: CHEBI:171664 name: antiamoebic agent namespace: chebi_ontology def: "An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae." [] subset: 3_STAR synonym: "amebicide" RELATED [ChEBI] synonym: "amebicides" RELATED [ChEBI] synonym: "amoebicide" RELATED [ChEBI] synonym: "amoebicides" RELATED [ChEBI] synonym: "anti-amoebic agent" RELATED [ChEBI] synonym: "anti-amoebic agents" RELATED [ChEBI] synonym: "anti-amoebic drug" RELATED [ChEBI] synonym: "anti-amoebic drugs" RELATED [ChEBI] synonym: "antiamoebic" RELATED [ChEBI] synonym: "antiamoebic agents" RELATED [ChEBI] synonym: "antiamoebic drug" RELATED [ChEBI] synonym: "antiamoebic drugs" RELATED [ChEBI] synonym: "antiamoebics" RELATED [ChEBI] is_a: CHEBI:35442 ! antiparasitic agent [Term] id: CHEBI:17203 name: L-proline namespace: chebi_ontology alt_id: CHEBI:13154 alt_id: CHEBI:184637 alt_id: CHEBI:21373 alt_id: CHEBI:42067 alt_id: CHEBI:45040 alt_id: CHEBI:45100 alt_id: CHEBI:45159 alt_id: CHEBI:6286 def: "Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles." [] subset: 3_STAR synonym: "(-)-(S)-proline" RELATED [NIST_Chemistry_WebBook] synonym: "(-)-2-pyrrolidinecarboxylic acid" RELATED [ChemIDplus] synonym: "(-)-proline" RELATED [ChemIDplus] synonym: "(2S)-pyrrolidine-2-carboxylic acid" RELATED [IUPAC] synonym: "(S)-2-carboxypyrrolidine" RELATED [DrugBank] synonym: "(S)-2-pyrrolidinecarboxylic acid" RELATED [ChemIDplus] synonym: "(S)-pyrrolidine-2-carboxylic acid" RELATED [ChEBI] synonym: "2-Pyrrolidinecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "L-(-)-proline" RELATED [NIST_Chemistry_WebBook] synonym: "L-alpha-pyrrolidinecarboxylic acid" RELATED [ChemIDplus] synonym: "L-Prolin" RELATED [ChEBI] synonym: "L-Proline" EXACT [KEGG_COMPOUND] synonym: "L-pyrrolidine-2-carboxylic acid" RELATED [ChemIDplus] synonym: "P" RELATED [ChEBI] synonym: "prolina" RELATED [ChemIDplus] synonym: "PROLINE" RELATED [PDBeChem] synonym: "prolinum" RELATED [ChemIDplus] xref: DrugBank:DB00172 xref: HMDB:HMDB0000162 xref: KEGG:C00148 xref: KEGG:D00035 xref: KNApSAcK:C00001388 xref: MetaCyc:PRO xref: PDBeChem:PRO xref: Wikipedia:L-proline is_a: CHEBI:24318 ! glutamine family amino acid is_a: CHEBI:26271 ! proline relationship: is_conjugate_acid_of CHEBI:32862 ! L-prolinate relationship: is_conjugate_base_of CHEBI:32864 ! L-prolinium relationship: is_enantiomer_of CHEBI:16313 ! D-proline relationship: is_tautomer_of CHEBI:60039 ! L-proline zwitterion relationship: RO:0000087 CHEBI:23366 ! has role compatible osmolytes relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite [Term] id: CHEBI:17234 name: glucose namespace: chebi_ontology alt_id: CHEBI:14313 alt_id: CHEBI:24277 alt_id: CHEBI:33929 alt_id: CHEBI:5418 def: "An aldohexose used as a source of energy and metabolic intermediate." [] subset: 3_STAR synonym: "DL-glucose" RELATED [ChEBI] synonym: "Glc" RELATED [JCBN] synonym: "Glucose" EXACT [KEGG_COMPOUND] synonym: "Glukose" RELATED [ChEBI] xref: KEGG:C00293 xref: Wikipedia:Glucose is_a: CHEBI:33917 ! aldohexose relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite [Term] id: CHEBI:17296 name: aniline namespace: chebi_ontology alt_id: CHEBI:13834 alt_id: CHEBI:22561 alt_id: CHEBI:2732 alt_id: CHEBI:40796 def: "A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens." [] subset: 3_STAR synonym: "aminobenzene" RELATED [ChemIDplus] synonym: "aminophen" RELATED [ChemIDplus] synonym: "Anilin" RELATED [NIST_Chemistry_WebBook] synonym: "ANILINE" EXACT [PDBeChem] synonym: "Aniline" EXACT [KEGG_COMPOUND] synonym: "aniline" EXACT [UniProt] synonym: "Benzenamine" RELATED [KEGG_COMPOUND] synonym: "benzeneamine" RELATED [NIST_Chemistry_WebBook] synonym: "kyanol" RELATED [NIST_Chemistry_WebBook] synonym: "Phenylamine" RELATED [KEGG_COMPOUND] xref: DrugBank:DB06728 xref: HMDB:HMDB0003012 xref: KEGG:C00292 xref: MetaCyc:ANILINE xref: PDBeChem:ANL xref: Wikipedia:Aniline is_a: CHEBI:22562 ! anilines is_a: CHEBI:50471 ! primary arylamine [Term] id: CHEBI:173084 name: ferroptosis inhibitor namespace: chebi_ontology def: "Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." [] subset: 3_STAR synonym: "ferroptosis inhibitors" RELATED [ChEBI] xref: Wikipedia:Ferroptosis is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:17334 name: penicillin namespace: chebi_ontology alt_id: CHEBI:14742 alt_id: CHEBI:25869 alt_id: CHEBI:7961 def: "Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6." [] subset: 3_STAR synonym: "Penicillin" EXACT [KEGG_COMPOUND] synonym: "penicillins" RELATED [ChEBI] xref: KEGG:C00395 xref: Wikipedia:Penicillin is_a: CHEBI:25865 ! penicillanic acids relationship: has_functional_parent CHEBI:16705 ! 6-aminopenicillanic acid relationship: is_conjugate_acid_of CHEBI:51356 ! penicillinate anion relationship: RO:0000087 CHEBI:50904 ! has role allergen [Term] id: CHEBI:17359 name: sulfite namespace: chebi_ontology alt_id: CHEBI:15139 alt_id: CHEBI:45548 def: "A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3)." [] subset: 3_STAR synonym: "[SO3](2-)" RELATED [IUPAC] synonym: "SO3" RELATED [ChEBI] synonym: "SO3(2-)" RELATED [IUPAC] synonym: "sulfite" EXACT [UniProt] synonym: "SULFITE ION" RELATED [PDBeChem] synonym: "sulphite" RELATED [ChEBI] xref: PDBeChem:SO3 is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:17137 ! hydrogensulfite [Term] id: CHEBI:17418 name: valeric acid namespace: chebi_ontology alt_id: CHEBI:113448 alt_id: CHEBI:27263 alt_id: CHEBI:27264 alt_id: CHEBI:43606 alt_id: CHEBI:44803 alt_id: CHEBI:7980 def: "A straight-chain saturated fatty acid containing five carbon atoms." [] subset: 3_STAR synonym: "1-butanecarboxylic acid" RELATED [ChemIDplus, NIST_Chemistry_WebBook] synonym: "CH3-[CH2]3-COOH" RELATED [IUPAC] synonym: "n-BuCOOH" RELATED [ChEBI] synonym: "n-Pentanoate" RELATED [KEGG_COMPOUND] synonym: "n-pentanoic acid" RELATED [ChemIDplus] synonym: "n-Valeric acid" RELATED [KEGG_COMPOUND] synonym: "n-valeric acid" RELATED [ChemIDplus] synonym: "Pentanoate" RELATED [KEGG_COMPOUND] synonym: "PENTANOIC ACID" RELATED [PDBeChem] synonym: "Pentanoic acid" RELATED [KEGG_COMPOUND] synonym: "pentoic acid" RELATED [ChEBI] synonym: "propylacetic acid" RELATED [ChemIDplus] synonym: "Valerate" RELATED [KEGG_COMPOUND] synonym: "Valerianic acid" RELATED [KEGG_COMPOUND] synonym: "Valeriansaeure" RELATED [ChEBI] synonym: "Valeric acid" EXACT [KEGG_COMPOUND] synonym: "valeric acid, normal" RELATED [ChemIDplus] xref: DrugBank:DB02406 xref: HMDB:HMDB0000892 xref: KEGG:C00803 xref: KNApSAcK:C00001208 xref: PDBeChem:LEA xref: PPDB:3130 xref: Wikipedia:Valeric_acid is_a: CHEBI:26666 ! short-chain fatty acid is_a: CHEBI:39418 ! straight-chain saturated fatty acid relationship: is_conjugate_acid_of CHEBI:31011 ! valerate relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:17478 name: aldehyde namespace: chebi_ontology alt_id: CHEBI:13432 alt_id: CHEBI:13753 alt_id: CHEBI:13805 alt_id: CHEBI:13806 alt_id: CHEBI:22291 alt_id: CHEBI:2554 alt_id: CHEBI:8750 def: "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." [] subset: 3_STAR synonym: "aldehido" RELATED [ChEBI] synonym: "aldehidos" RELATED [ChEBI] synonym: "Aldehyd" RELATED [ChEBI] synonym: "Aldehyde" EXACT [KEGG_COMPOUND] synonym: "aldehyde" EXACT [ChEBI] synonym: "aldehydes" RELATED [ChEBI] synonym: "aldehydum" RELATED [ChEBI] synonym: "an aldehyde" RELATED [UniProt] synonym: "RC(=O)H" RELATED [IUPAC] synonym: "RCHO" RELATED [KEGG_COMPOUND] xref: KEGG:C00071 is_a: CHEBI:36586 ! carbonyl compound relationship: BFO:0000051 CHEBI:42485 ! has part formyl group [Term] id: CHEBI:17489 name: 3',5'-cyclic AMP namespace: chebi_ontology alt_id: CHEBI:11673 alt_id: CHEBI:1325 alt_id: CHEBI:19827 alt_id: CHEBI:41588 def: "A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase." [] subset: 3_STAR synonym: "3',5'-Cyclic AMP" EXACT [KEGG_COMPOUND] synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [NIST_Chemistry_WebBook] synonym: "Adenosine 3',5'-cyclic phosphate" RELATED [KEGG_COMPOUND] synonym: "Adenosine 3',5'-phosphate" RELATED [KEGG_COMPOUND] synonym: "ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE" RELATED [PDBeChem] synonym: "cAMP" RELATED [KEGG_COMPOUND] synonym: "Cyclic adenylic acid" RELATED [KEGG_COMPOUND] synonym: "Cyclic AMP" RELATED [KEGG_COMPOUND] xref: DrugBank:DB02527 xref: HMDB:HMDB0000058 xref: KEGG:C00575 xref: KNApSAcK:C00001497 xref: MetaCyc:CAMP xref: PDBeChem:CMP xref: Wikipedia:Cyclic_AMP is_a: CHEBI:19834 ! 3',5'-cyclic purine nucleotide is_a: CHEBI:61296 ! adenyl ribonucleotide relationship: is_conjugate_acid_of CHEBI:58165 ! 3',5'-cyclic AMP(1-) relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17499 name: hydrogen donor namespace: chebi_ontology alt_id: CHEBI:13233 alt_id: CHEBI:15018 alt_id: CHEBI:8785 def: "A molecular entity that can undergo oxidation by the loss of hydrogen atom(s)." [] subset: 3_STAR synonym: "AH2" RELATED [KEGG_COMPOUND, UniProt] synonym: "Donor" RELATED [KEGG_COMPOUND] synonym: "Hydrogen-donor" RELATED [KEGG_COMPOUND] synonym: "Reduced acceptor" RELATED [KEGG_COMPOUND] xref: KEGG:C00030 is_a: CHEBI:23367 ! molecular entity relationship: RO:0000087 CHEBI:15022 ! has role electron donor [Term] id: CHEBI:17514 name: cyanide namespace: chebi_ontology alt_id: CHEBI:14038 alt_id: CHEBI:3969 alt_id: CHEBI:41780 def: "A pseudohalide anion that is the conjugate base of hydrogen cyanide." [] subset: 3_STAR synonym: "CN(-)" RELATED [IUPAC] synonym: "CN-" RELATED [KEGG_COMPOUND] synonym: "Cyanide" EXACT [ChEBI, KEGG_COMPOUND] synonym: "CYANIDE ION" RELATED [PDBeChem] synonym: "Prussiate" RELATED [KEGG_COMPOUND] synonym: "Zyanid" RELATED [ChEBI] xref: HMDB:HMDB0002084 xref: KEGG:C00177 xref: MetaCyc:CPD-13584 xref: PDBeChem:CYN xref: Wikipedia:Cyanide is_a: CHEBI:36828 ! pseudohalide anion relationship: is_conjugate_base_of CHEBI:18407 ! hydrogen cyanide relationship: is_conjugate_base_of CHEBI:36856 ! hydrogen isocyanide relationship: RO:0000087 CHEBI:38500 ! has role EC 1.9.3.1 (cytochrome c oxidase) inhibitor [Term] id: CHEBI:17522 name: alditol namespace: chebi_ontology alt_id: CHEBI:13754 alt_id: CHEBI:22298 alt_id: CHEBI:2556 def: "A carbohydrate that is an acyclic polyol having the general formula HOCH2[CH(OH)]nCH2OH (formally derivable from an aldose by reduction of the carbonyl group)." [] subset: 3_STAR synonym: "Alditol" EXACT [KEGG_COMPOUND] synonym: "alditol" EXACT [UniProt] synonym: "alditols" RELATED [ChEBI] synonym: "Glycitol" RELATED [KEGG_COMPOUND] synonym: "Sugar alcohol" RELATED [KEGG_COMPOUND] xref: KEGG:C00717 xref: Wikipedia:Glycerin is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:17544 name: hydrogencarbonate namespace: chebi_ontology alt_id: CHEBI:13363 alt_id: CHEBI:22863 alt_id: CHEBI:40961 alt_id: CHEBI:5589 def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." [] subset: 3_STAR synonym: "[CO2(OH)](-)" RELATED [IUPAC] synonym: "Acid carbonate" RELATED [KEGG_COMPOUND] synonym: "Bicarbonate" RELATED [KEGG_COMPOUND] synonym: "BICARBONATE ION" RELATED [PDBeChem] synonym: "HCO3(-)" RELATED [IUPAC] synonym: "HCO3-" RELATED [KEGG_COMPOUND] synonym: "hydrogen carbonate" RELATED [PDBeChem] synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND] synonym: "hydrogencarbonate" EXACT [UniProt] xref: HMDB:HMDB0000595 xref: KEGG:C00288 xref: MetaCyc:HCO3 xref: PDBeChem:BCT xref: Wikipedia:Bicarbonate is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17568 name: uracil namespace: chebi_ontology alt_id: CHEBI:15288 alt_id: CHEBI:27210 alt_id: CHEBI:46375 alt_id: CHEBI:9882 def: "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." [] subset: 3_STAR synonym: "2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook] synonym: "2,4-Dioxopyrimidine" RELATED [HMDB] synonym: "2,4-Pyrimidinedione" RELATED [HMDB] synonym: "U" RELATED [ChEBI] synonym: "Ura" RELATED [CBN] synonym: "URACIL" EXACT [PDBeChem] synonym: "Uracil" EXACT [KEGG_COMPOUND] synonym: "uracil" EXACT [UniProt] synonym: "Urazil" RELATED [ChEBI] xref: DrugBank:DB03419 xref: HMDB:HMDB0000300 xref: KEGG:C00106 xref: KEGG:D00027 xref: KNApSAcK:C00001513 xref: MetaCyc:URACIL xref: PDBeChem:URA xref: Wikipedia:Uracil is_a: CHEBI:26432 ! pyrimidine nucleobase is_a: CHEBI:38337 ! pyrimidone relationship: is_tautomer_of CHEBI:43254 ! (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one relationship: RO:0000087 CHEBI:50266 ! has role prodrug relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite [Term] id: CHEBI:17608 name: D-aldohexose namespace: chebi_ontology alt_id: CHEBI:12990 alt_id: CHEBI:21038 def: "Any D-aldose having a chain of six carbon atoms in the molecule." [] subset: 3_STAR synonym: "D-aldohexoses" RELATED [ChEBI] is_a: CHEBI:33917 ! aldohexose is_a: CHEBI:4194 ! D-hexose [Term] id: CHEBI:17630 name: kanamycin A namespace: chebi_ontology alt_id: CHEBI:14487 alt_id: CHEBI:24945 alt_id: CHEBI:24947 alt_id: CHEBI:43482 alt_id: CHEBI:6106 subset: 3_STAR synonym: "4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside" RELATED [ChemIDplus] synonym: "4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside" RELATED [ChemIDplus] synonym: "KANAMYCIN A" EXACT [PDBeChem] synonym: "Kanamycin A" EXACT [KEGG_COMPOUND] synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine" RELATED [ChemIDplus] xref: DrugBank:DB01172 xref: KEGG:C01822 xref: LINCS:LSM-5261 xref: PDBeChem:KAN xref: VSDB:1921 xref: Wikipedia:Kanamycin is_a: CHEBI:24951 ! kanamycins relationship: is_conjugate_base_of CHEBI:58214 ! kanamycin A(4+) relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:17634 name: D-glucose namespace: chebi_ontology alt_id: CHEBI:12965 alt_id: CHEBI:20999 def: "A glucose with D-configuration." [] subset: 3_STAR synonym: "D(+)-glucose" RELATED [ChemIDplus] synonym: "D-(+)-glucose" RELATED [NIST_Chemistry_WebBook] synonym: "dextrose" RELATED [NIST_Chemistry_WebBook] synonym: "grape sugar" RELATED [ChemIDplus] synonym: "Traubenzucker" RELATED [ChemIDplus] is_a: CHEBI:17234 ! glucose is_a: CHEBI:17608 ! D-aldohexose [Term] id: CHEBI:176497 name: geroprotector namespace: chebi_ontology def: "Any compound that supports healthy aging, slows the biological aging process, or extends lifespan." [] subset: 3_STAR synonym: "anti-aging agent" RELATED [ChEBI] synonym: "anti-aging agents" RELATED [ChEBI] synonym: "anti-aging drug" RELATED [ChEBI] synonym: "anti-aging drugs" RELATED [ChEBI] synonym: "geroprotective agent" RELATED [ChEBI] synonym: "geroprotective agents" RELATED [ChEBI] synonym: "geroprotectors" RELATED [ChEBI] xref: Wikipedia:Geroprotector is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:17658 name: tylosin namespace: chebi_ontology alt_id: CHEBI:15275 alt_id: CHEBI:27172 alt_id: CHEBI:46150 alt_id: CHEBI:9787 def: "A macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of Streptomyces fradiae." [] subset: 3_STAR synonym: "Tylan" RELATED [ChemIDplus] synonym: "Tylocine" RELATED [ChemIDplus] synonym: "Tylosin" EXACT [KEGG_COMPOUND] synonym: "Tylosin A" RELATED [ChemIDplus] xref: HMDB:HMDB0034108 xref: KEGG:C01457 xref: KEGG:D02490 xref: MetaCyc:TYLOSIN xref: Patent:US2004082524 xref: PDBeChem:TYK xref: Wikipedia:Tylosin is_a: CHEBI:17478 ! aldehyde is_a: CHEBI:25022 ! leucomycin is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:51689 ! enone is_a: CHEBI:63353 ! disaccharide derivative is_a: CHEBI:63367 ! monosaccharide derivative relationship: has_functional_parent CHEBI:29700 ! tylactone relationship: is_conjugate_base_of CHEBI:77047 ! tylosin(1+) relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:176839 name: vitamin B3 namespace: chebi_ontology def: "Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms)." [] subset: 3_STAR synonym: "vitamin B-3" RELATED [ChEBI] synonym: "vitamin B3" EXACT [ChEBI] synonym: "vitamin B3 vitamer" RELATED [ChEBI] synonym: "vitamin B3 vitamers" RELATED [ChEBI] synonym: "vitamins B3" RELATED [ChEBI] is_a: CHEBI:75769 ! B vitamin [Term] id: CHEBI:17698 name: chloramphenicol namespace: chebi_ontology alt_id: CHEBI:13965 alt_id: CHEBI:23106 alt_id: CHEBI:23108 alt_id: CHEBI:3603 alt_id: CHEBI:47327 def: "An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions." [] subset: 3_STAR synonym: "(-)-chloramphenicol" RELATED [ChEBI] synonym: "CHLORAMPHENICOL" EXACT [PDBeChem] synonym: "Chloramphenicol" EXACT [KEGG_COMPOUND] synonym: "chloramphenicol" EXACT [UniProt] synonym: "chlornitromycin" RELATED [ChEBI] synonym: "D-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide" RELATED [ChemIDplus] synonym: "D-(-)-threo-1-p-nitrophenyl-2-dichloroacetylamino-1,3-propanediol" RELATED [ChemIDplus] synonym: "laevomycetinum" RELATED [ChemIDplus] synonym: "levomicetina" RELATED [ChemIDplus] synonym: "levomycetin" RELATED [ChemIDplus] xref: Chemspider:5744 xref: DrugBank:DB00446 xref: HMDB:HMDB0014589 xref: KEGG:C00918 xref: KEGG:D00104 xref: LINCS:LSM-5256 xref: MetaCyc:CHLORAMPHENICOL xref: Patent:GB795131 xref: Patent:GB796901 xref: Patent:US2483871 xref: Patent:US2483884 xref: Patent:US2483892 xref: Patent:US2839577 xref: PDBeChem:CLM xref: VSDB:1835 xref: Wikipedia:Chloramphenicol is_a: CHEBI:23824 ! diol is_a: CHEBI:35716 ! C-nitro compound is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:37622 ! carboxamide relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:17790 name: methanol namespace: chebi_ontology alt_id: CHEBI:14588 alt_id: CHEBI:25227 alt_id: CHEBI:44080 alt_id: CHEBI:44553 alt_id: CHEBI:6816 def: "The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group." [] subset: 3_STAR synonym: "carbinol" RELATED [ChemIDplus] synonym: "CH3OH" RELATED [ChEBI] synonym: "MeOH" RELATED [ChEBI] synonym: "METHANOL" EXACT [PDBeChem] synonym: "Methanol" EXACT [KEGG_COMPOUND] synonym: "methanol" EXACT [UniProt] synonym: "Methyl alcohol" RELATED [KEGG_COMPOUND] synonym: "Methylalkohol" RELATED [NIST_Chemistry_WebBook] synonym: "spirit of wood" RELATED [HMDB] synonym: "wood alcohol" RELATED [ChemIDplus] synonym: "wood naphtha" RELATED [ChemIDplus] synonym: "wood spirit" RELATED [NIST_Chemistry_WebBook] xref: HMDB:HMDB0001875 xref: KEGG:C00132 xref: KEGG:D02309 xref: MetaCyc:METOH xref: PDBeChem:MOH xref: Wikipedia:Methanol is_a: CHEBI:134179 ! volatile organic compound is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:50584 ! alkyl alcohol is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:52090 ! methoxide relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite relationship: RO:0000087 CHEBI:33292 ! has role fuel relationship: RO:0000087 CHEBI:48360 ! has role amphiprotic solvent relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:17792 name: organohalogen compound namespace: chebi_ontology alt_id: CHEBI:13444 alt_id: CHEBI:36684 alt_id: CHEBI:8767 def: "A compound containing at least one carbon-halogen bond (where X is a halogen atom)." [] subset: 3_STAR synonym: "organic halide" RELATED [KEGG_COMPOUND] synonym: "organic halides" RELATED [ChEBI] synonym: "organohalogen compounds" RELATED [ChEBI] synonym: "RX" RELATED [KEGG_COMPOUND, UniProt] xref: KEGG:C01322 xref: MetaCyc:Organohalogen-Compounds is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:37578 ! halide [Term] id: CHEBI:17822 name: serine namespace: chebi_ontology alt_id: CHEBI:15081 alt_id: CHEBI:26648 alt_id: CHEBI:9116 def: "An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group." [] subset: 3_STAR synonym: "2-amino-3-hydroxypropanoic acid" RELATED [IUPAC] synonym: "2-Amino-3-hydroxypropionic acid" RELATED [KEGG_COMPOUND] synonym: "3-Hydroxyalanine" RELATED [KEGG_COMPOUND] synonym: "Serin" RELATED [ChEBI] synonym: "Serine" EXACT [KEGG_COMPOUND] xref: KEGG:C00716 xref: KNApSAcK:C00001393 xref: Wikipedia:Serine is_a: CHEBI:26167 ! polar amino acid is_a: CHEBI:33704 ! alpha-amino acid relationship: BFO:0000051 CHEBI:24712 ! has part hydroxymethyl group relationship: is_conjugate_acid_of CHEBI:32845 ! serinate relationship: is_conjugate_base_of CHEBI:32846 ! serinium relationship: is_tautomer_of CHEBI:35243 ! serine zwitterion relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite [Term] id: CHEBI:17833 name: gentamycin namespace: chebi_ontology alt_id: CHEBI:14293 alt_id: CHEBI:24206 alt_id: CHEBI:24212 alt_id: CHEBI:5306 def: "Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp." [] subset: 3_STAR synonym: "Gentamicin" RELATED [KEGG_COMPOUND] synonym: "gentamycins" RELATED [ChEBI] xref: DrugBank:DB00798 xref: KEGG:C00505 is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:17883 name: hydrogen chloride namespace: chebi_ontology alt_id: CHEBI:13364 alt_id: CHEBI:24635 alt_id: CHEBI:5590 def: "A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms." [] subset: 3_STAR synonym: "[HCl]" RELATED [IUPAC] synonym: "chlorure d'hydrogene" RELATED [ChEBI] synonym: "Chlorwasserstoff" RELATED [ChEBI] synonym: "cloruro de hidrogeno" RELATED [ChEBI] synonym: "HCl" RELATED [KEGG_COMPOUND] synonym: "hydrochloric acid" RELATED [ChemIDplus] synonym: "Hydrochloride" RELATED [KEGG_COMPOUND] synonym: "Hydrogen chloride" EXACT [KEGG_COMPOUND] synonym: "Hydrogenchlorid" RELATED [ChEBI] synonym: "Wasserstoffchlorid" RELATED [ChEBI] xref: HMDB:HMDB0002306 xref: KEGG:C01327 xref: KEGG:D02057 xref: MetaCyc:HCL xref: Wikipedia:HCl xref: Wikipedia:Hydrochloric_acid is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:18140 ! hydrogen halide is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:37176 ! mononuclear parent hydride relationship: is_conjugate_acid_of CHEBI:17996 ! chloride relationship: is_conjugate_base_of CHEBI:50315 ! chloronium relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite [Term] id: CHEBI:17891 name: donor namespace: chebi_ontology alt_id: CHEBI:14202 alt_id: CHEBI:4697 def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." [] subset: 3_STAR synonym: "Donator" RELATED [ChEBI] synonym: "donneur" RELATED [ChEBI] synonym: "Donor" EXACT [KEGG_COMPOUND] xref: KEGG:C01351 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:17925 name: alpha-D-glucose namespace: chebi_ontology alt_id: CHEBI:10242 alt_id: CHEBI:12318 alt_id: CHEBI:22386 alt_id: CHEBI:40557 alt_id: CHEBI:42802 def: "D-Glucopyranose having alpha-configuration at the anomeric centre." [] subset: 3_STAR synonym: "alpha-D-Glc" RELATED [ChEBI] synonym: "ALPHA-D-GLUCOSE" EXACT [PDBeChem] synonym: "alpha-D-Glucose" EXACT [KEGG_COMPOUND] synonym: "alpha-D-glucose" EXACT [UniProt] synonym: "alpha-dextrose" RELATED [ChemIDplus] synonym: "WURCS=2.0/1,1,0/[a2122h-1a_1-5]/1/" RELATED [GlyTouCan] xref: GlyGen:G58161NS xref: GlyTouCan:G58161NS xref: KEGG:C00267 xref: KNApSAcK:C00001122 xref: PDBeChem:GLC is_a: CHEBI:4167 ! D-glucopyranose relationship: is_enantiomer_of CHEBI:37630 ! alpha-L-glucose [Term] id: CHEBI:17996 name: chloride namespace: chebi_ontology alt_id: CHEBI:13291 alt_id: CHEBI:13970 alt_id: CHEBI:3616 alt_id: CHEBI:3731 alt_id: CHEBI:48804 def: "A halide anion formed when chlorine picks up an electron to form an an anion." [] subset: 3_STAR synonym: "Chloride" EXACT [KEGG_COMPOUND] synonym: "chloride" EXACT [UniProt] synonym: "CHLORIDE ION" RELATED [PDBeChem] synonym: "Chloride ion" RELATED [KEGG_COMPOUND] synonym: "Chloride(1-)" RELATED [ChemIDplus] synonym: "Chlorine anion" RELATED [NIST_Chemistry_WebBook] synonym: "Cl(-)" RELATED [IUPAC] synonym: "Cl-" RELATED [KEGG_COMPOUND] xref: FooDB:FDB006557 xref: HMDB:HMDB0000492 xref: KEGG:C00698 xref: MetaCyc:CL- xref: PDBeChem:CL xref: Wikipedia:Chloride is_a: CHEBI:16042 ! halide anion is_a: CHEBI:33432 ! monoatomic chlorine relationship: is_conjugate_base_of CHEBI:17883 ! hydrogen chloride relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:18059 name: lipid namespace: chebi_ontology alt_id: CHEBI:14517 alt_id: CHEBI:25054 alt_id: CHEBI:6486 def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." [] subset: 3_STAR synonym: "Lipid" EXACT [KEGG_COMPOUND] xref: KEGG:C01356 is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:18133 name: hexose namespace: chebi_ontology alt_id: CHEBI:14399 alt_id: CHEBI:24590 alt_id: CHEBI:5709 def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." [] subset: 3_STAR synonym: "Hexose" EXACT [KEGG_COMPOUND] synonym: "hexoses" RELATED [ChEBI] synonym: "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/" RELATED [GlyTouCan] xref: GlyGen:G70994MS xref: GlyTouCan:G70994MS xref: KEGG:C00738 is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:18140 name: hydrogen halide namespace: chebi_ontology alt_id: CHEBI:13368 alt_id: CHEBI:37140 alt_id: CHEBI:5599 subset: 3_STAR synonym: "hydrogen halide" EXACT [IUPAC] synonym: "hydrogen halides" RELATED [ChEBI] is_a: CHEBI:33405 ! hydracid relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid [Term] id: CHEBI:18154 name: polysaccharide namespace: chebi_ontology alt_id: CHEBI:14864 alt_id: CHEBI:26205 alt_id: CHEBI:8322 def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." [] subset: 3_STAR synonym: "Glycan" RELATED [KEGG_COMPOUND] synonym: "Glycane" RELATED [ChEBI] synonym: "glycans" RELATED [IUPAC] synonym: "Glykan" RELATED [ChEBI] synonym: "Glykane" RELATED [ChEBI] synonym: "polisacarido" RELATED [ChEBI] synonym: "polisacaridos" RELATED [IUPAC] synonym: "Polysaccharide" EXACT [KEGG_COMPOUND] xref: KEGG:C00420 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:18208 name: benzylpenicillin namespace: chebi_ontology alt_id: CHEBI:14743 alt_id: CHEBI:25866 alt_id: CHEBI:45073 alt_id: CHEBI:7962 def: "A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [ChEBI] synonym: "6-(2-phenylacetamido)penicillanic acid" RELATED [ChemIDplus] synonym: "bensylpenicillin" RELATED [ChEBI] synonym: "benzyl benicillin" RELATED [ChEBI] synonym: "Benzylpenicillin" EXACT [KEGG_COMPOUND] synonym: "benzylpenicillinic acid" RELATED [ChemIDplus] synonym: "free penicillin II" RELATED [ChemIDplus] synonym: "PCG" RELATED [ChEBI] synonym: "PENICILLIN G" RELATED [PDBeChem] synonym: "Penicillin G" RELATED [KEGG_COMPOUND] synonym: "PG" RELATED [ChEBI] xref: DrugBank:DB01053 xref: HMDB:HMDB0015186 xref: KEGG:C05551 xref: KEGG:D02336 xref: LINCS:LSM-3229 xref: Patent:US3024169 xref: PDBeChem:PNN xref: Wikipedia:Benzylpenicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51354 ! benzylpenicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:53000 ! has role epitope relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:18254 name: ribonucleoside namespace: chebi_ontology alt_id: CHEBI:13014 alt_id: CHEBI:13015 alt_id: CHEBI:13685 alt_id: CHEBI:21085 alt_id: CHEBI:26560 alt_id: CHEBI:4240 alt_id: CHEBI:8844 def: "Any nucleoside where the sugar component is D-ribose." [] subset: 3_STAR synonym: "a ribonucleoside" RELATED [UniProt] synonym: "Ribonucleoside" EXACT [KEGG_COMPOUND] synonym: "ribonucleosides" RELATED [ChEBI] xref: KEGG:C00911 is_a: CHEBI:33838 ! nucleoside is_a: CHEBI:47019 ! dihydroxytetrahydrofuran [Term] id: CHEBI:18257 name: ornithine namespace: chebi_ontology alt_id: CHEBI:7784 def: "An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5." [] subset: 3_STAR synonym: "2,5-Diaminopentanoic acid" RELATED [KEGG_COMPOUND] synonym: "2,5-Diaminovaleric acid" RELATED [KEGG_COMPOUND] synonym: "DL-Ornithine" RELATED [ChemIDplus] synonym: "Orn" RELATED [IUPAC] synonym: "Ornithine" EXACT [KEGG_COMPOUND] xref: KEGG:C01602 xref: KNApSAcK:C00001384 is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid relationship: is_conjugate_acid_of CHEBI:32964 ! ornithinate relationship: is_conjugate_base_of CHEBI:46912 ! ornithinium(1+) relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite [Term] id: CHEBI:18282 name: nucleobase namespace: chebi_ontology alt_id: CHEBI:13873 alt_id: CHEBI:25598 alt_id: CHEBI:2995 def: "That part of DNA or RNA that may be involved in pairing." [] subset: 3_STAR synonym: "Base" RELATED [KEGG_COMPOUND] synonym: "nucleobases" RELATED [ChEBI] xref: KEGG:C00701 xref: Wikipedia:Nucleobase is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:18291 name: manganese atom namespace: chebi_ontology alt_id: CHEBI:13382 alt_id: CHEBI:25153 alt_id: CHEBI:6681 subset: 3_STAR synonym: "25Mn" RELATED [IUPAC] synonym: "Mangan" RELATED [NIST_Chemistry_WebBook] synonym: "Manganese" RELATED [KEGG_COMPOUND] synonym: "manganese" RELATED [ChEBI] synonym: "manganeso" RELATED [ChEBI] synonym: "manganum" RELATED [ChEBI] synonym: "Mn" RELATED [IUPAC, UniProt] xref: KEGG:C00034 xref: WebElements:Mn is_a: CHEBI:33352 ! manganese group element atom relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:18310 name: alkane namespace: chebi_ontology alt_id: CHEBI:13435 alt_id: CHEBI:22317 alt_id: CHEBI:2576 def: "An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." [] subset: 3_STAR synonym: "alcane" RELATED [IUPAC] synonym: "alcanes" RELATED [IUPAC] synonym: "alcano" RELATED [IUPAC] synonym: "alcanos" RELATED [IUPAC] synonym: "Alkan" RELATED [ChEBI] synonym: "Alkane" EXACT [KEGG_COMPOUND] synonym: "an alkane" RELATED [UniProt] synonym: "RH" RELATED [KEGG_COMPOUND] xref: KEGG:C01371 is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:33653 ! aliphatic compound [Term] id: CHEBI:18320 name: 1,4-dithiothreitol namespace: chebi_ontology alt_id: CHEBI:11174 alt_id: CHEBI:23854 alt_id: CHEBI:4664 def: "The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol." [] subset: 3_STAR synonym: "(R*,R*)-1,4-dimercapto-2,3-butanediol" RELATED [NIST_Chemistry_WebBook] synonym: "1,4-Dithiothreitol" EXACT [KEGG_COMPOUND] synonym: "1,4-dithiothreitol" EXACT [UniProt] synonym: "Cleland's reagent" RELATED [NIST_Chemistry_WebBook] synonym: "Dithiothreitol" RELATED [KEGG_COMPOUND] synonym: "Dithiotreitol" RELATED [ChemIDplus] synonym: "DL-threo-1,4-Dimercapto-2,3-butanediol" RELATED [ChemIDplus] synonym: "DTL" RELATED [ChEBI] synonym: "DTT" RELATED [ChEBI] synonym: "rac-Dithiothreitol" RELATED [ChemIDplus] synonym: "threo-1,4-Dimercapto-2,3-butanediol" RELATED [KEGG_COMPOUND] xref: DrugBank:DB04447 xref: KEGG:C00265 xref: LINCS:LSM-36870 is_a: CHEBI:23853 ! dithiol is_a: CHEBI:25189 ! 1,4-dimercaptobutane-2,3-diol relationship: RO:0000087 CHEBI:38161 ! has role chelator relationship: RO:0000087 CHEBI:63247 ! has role reducing agent relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:18367 name: phosphate(3-) namespace: chebi_ontology alt_id: CHEBI:14791 alt_id: CHEBI:45024 alt_id: CHEBI:7793 def: "A phosphate ion that is the conjugate base of hydrogenphosphate." [] subset: 3_STAR synonym: "[PO4](3-)" RELATED [IUPAC] synonym: "Orthophosphate" RELATED [KEGG_COMPOUND] synonym: "Phosphate" RELATED [KEGG_COMPOUND] synonym: "PHOSPHATE ION" RELATED [PDBeChem] synonym: "PO4(3-)" RELATED [IUPAC] xref: KEGG:C00009 xref: PDBeChem:PO4 xref: Wikipedia:Phosphate is_a: CHEBI:35780 ! phosphate ion is_a: CHEBI:79387 ! trivalent inorganic anion relationship: is_conjugate_base_of CHEBI:43474 ! hydrogenphosphate [Term] id: CHEBI:18375 name: nucleoside 3',5'-cyclic phosphate namespace: chebi_ontology alt_id: CHEBI:1331 alt_id: CHEBI:14672 alt_id: CHEBI:19833 def: "A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-3 and C-5 of the ribose ring are engaged in formation of a cyclic mono-, di-, tri- or tetra-phosphate." [] subset: 3_STAR synonym: "nucleoside 3',5'-cyclic phosphates" RELATED [ChEBI] is_a: CHEBI:23447 ! cyclic nucleotide relationship: is_conjugate_acid_of CHEBI:58464 ! nucleoside 3',5'-cyclic phosphate anion [Term] id: CHEBI:18379 name: nitrile namespace: chebi_ontology alt_id: CHEBI:13212 alt_id: CHEBI:13426 alt_id: CHEBI:13660 alt_id: CHEBI:25547 alt_id: CHEBI:7584 def: "A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it." [] subset: 3_STAR synonym: "a nitrile" RELATED [UniProt] synonym: "Nitril" RELATED [ChEBI] synonym: "Nitrile" EXACT [KEGG_COMPOUND] synonym: "nitrile" EXACT [IUPAC] synonym: "nitrilos" RELATED [IUPAC] synonym: "R-CN" RELATED [KEGG_COMPOUND] xref: KEGG:C00726 is_a: CHEBI:23424 ! cyanides relationship: BFO:0000051 CHEBI:48819 ! has part cyano group [Term] id: CHEBI:18407 name: hydrogen cyanide namespace: chebi_ontology alt_id: CHEBI:13362 alt_id: CHEBI:5786 def: "A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom" [] subset: 3_STAR synonym: "[CHN]" RELATED [IUPAC] synonym: "Blausaeure" RELATED [ChEBI] synonym: "Cyanwasserstoff" RELATED [NIST_Chemistry_WebBook] synonym: "formonitrile" RELATED [IUPAC] synonym: "HCN" RELATED [KEGG_COMPOUND] synonym: "hydrocyanic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Hydrogen cyanide" EXACT [KEGG_COMPOUND] synonym: "hydrogen cyanide" EXACT [IUPAC, UniProt] xref: HMDB:HMDB0060292 xref: KEGG:C01326 xref: KNApSAcK:C00007569 xref: MetaCyc:HCN xref: Wikipedia:Hydrogen_cyanide is_a: CHEBI:33405 ! hydracid is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:17514 ! cyanide relationship: is_tautomer_of CHEBI:36856 ! hydrogen isocyanide relationship: RO:0000087 CHEBI:64909 ! has role poison relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:184376 name: streptidine(2+) namespace: chebi_ontology def: "A guanidinium ion obtained by protonation of both guanidino groups of streptidine; major species at pH 7.3." [] subset: 3_STAR synonym: "streptidine" RELATED [UniProt] synonym: "streptidine dication" RELATED [ChEBI] synonym: "{[(1R,2s,3S,4R,5r,6S)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diazanediyl}bis(aminomethaniminium)" RELATED [IUPAC] is_a: CHEBI:60251 ! guanidinium ion relationship: is_conjugate_acid_of CHEBI:27405 ! streptidine [Term] id: CHEBI:184381 name: bacitracin A zwitterion namespace: chebi_ontology subset: 2_STAR synonym: "bacitracin A" RELATED [UniProt] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:28669 ! bacitracin [Term] id: CHEBI:18946 name: delta-lactone namespace: chebi_ontology def: "A lactone having a six-membered lactone ring." [] subset: 3_STAR synonym: "1,5-lactone" RELATED [ChEBI] synonym: "1,5-lactones" RELATED [ChEBI] synonym: "delta-lactona" RELATED [ChEBI] synonym: "delta-lactonas" RELATED [ChEBI] synonym: "delta-lactone" EXACT [ChEBI] synonym: "delta-lactones" RELATED [ChEBI] is_a: CHEBI:25000 ! lactone [Term] id: CHEBI:190303 name: inorganic potassium salt namespace: chebi_ontology def: "A potassium salt that lacks C-H bonds" [] subset: 2_STAR is_a: CHEBI:167164 ! mineral nutrient is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:26218 ! potassium salt [Term] id: CHEBI:190509 name: imipenem zwitterion namespace: chebi_ontology def: "Zwitterionic form of imipenem having an anionic carboxy group and a protonated methaneimidamido group; major species at pH 7.3." [] subset: 3_STAR synonym: "imipenem" RELATED [UniProt] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:471744 ! imipenem [Term] id: CHEBI:19129 name: 11alpha-hydroxy steroid namespace: chebi_ontology subset: 3_STAR synonym: "11alpha-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:36841 ! 11-hydroxy steroid [Term] id: CHEBI:192484 name: ciprofloxacin zwitterion namespace: chebi_ontology def: "A zwitterion formed from ciprofloxacin by transfer of a proton from the carboxy to the amino group; major species at pH 7.3." [] subset: 3_STAR xref: MetaCyc:CPD-12843 is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:100241 ! ciprofloxacin [Term] id: CHEBI:192486 name: ciprofloxacin(1+) namespace: chebi_ontology def: "A secondary ammonium ion that is the conjugate acid of ciprofloxacin resulting from the protonation of the NH group; major species at acidic pH." [] subset: 3_STAR synonym: "ciprofloxacin cation" RELATED [ChEBI] is_a: CHEBI:137419 ! secondary ammonium ion relationship: is_conjugate_acid_of CHEBI:100241 ! ciprofloxacin [Term] id: CHEBI:192979 name: nystatin A2 namespace: chebi_ontology subset: 3_STAR synonym: "nystatin A2" EXACT [ChemIDplus] is_a: CHEBI:59676 ! nystatins [Term] id: CHEBI:194135 name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid namespace: chebi_ontology def: "An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively." [] subset: 3_STAR is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:46920 ! N-methylpiperazine is_a: CHEBI:47881 ! 3-oxo monocarboxylic acid is_a: CHEBI:53665 ! oxazinoquinoline [Term] id: CHEBI:19834 name: 3',5'-cyclic purine nucleotide namespace: chebi_ontology subset: 3_STAR synonym: "3',5'-cyclic purine nucleotides" RELATED [ChEBI] is_a: CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate is_a: CHEBI:36982 ! cyclic purine nucleotide [Term] id: CHEBI:204928 name: cefotaxime namespace: chebi_ontology alt_id: CHEBI:112504 alt_id: CHEBI:3497 alt_id: CHEBI:41475 def: "A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups." [] subset: 3_STAR synonym: "(6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "(6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "(6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "Cephotaxime" RELATED [ChemIDplus] xref: DrugBank:DB00493 xref: KEGG:C06885 xref: KEGG:D07647 xref: Patent:DE2556736 xref: Patent:DE2702501 xref: Patent:US4098888 xref: Patent:US4152432 xref: PDBeChem:CE3 xref: Wikipedia:Cefotaxime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether is_a: CHEBI:38418 ! 1,3-thiazoles relationship: is_conjugate_acid_of CHEBI:53670 ! cefotaxime(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:20854 name: ATP synthase inhibitor namespace: chebi_ontology def: "A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase." [] subset: 3_STAR is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor [Term] id: CHEBI:209807 name: cefoxitin namespace: chebi_ontology alt_id: CHEBI:3500 alt_id: CHEBI:41436 alt_id: CHEBI:471714 alt_id: CHEBI:658070 def: "A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase." [] subset: 3_STAR synonym: "(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "Cefoxitin" EXACT [ChemIDplus] synonym: "Cephoxitin" RELATED [ChemIDplus] synonym: "CFX" RELATED [KEGG_DRUG] synonym: "Rephoxitin" RELATED [ChemIDplus] xref: DrugBank:DB01331 xref: HMDB:HMDB0015426 xref: KEGG:C06887 xref: KEGG:D02345 xref: LINCS:LSM-5786 xref: Patent:DE2129675 xref: Patent:DE2203653 xref: Patent:US4297488 xref: PDBeChem:CFX xref: Wikipedia:Cefoxitin is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:55429 ! cephamycin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_conjugate_acid_of CHEBI:53655 ! cefoxitin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:21638 name: N-acylglucosamine namespace: chebi_ontology subset: 3_STAR synonym: "N-acylglucosamine" EXACT [ChEBI] synonym: "N-acylglucosamines" RELATED [ChEBI] is_a: CHEBI:21656 ! N-acyl-hexosamine is_a: CHEBI:24271 ! glucosamines [Term] id: CHEBI:21656 name: N-acyl-hexosamine namespace: chebi_ontology subset: 3_STAR synonym: "N-acyl-hexosamine" EXACT [ChEBI] synonym: "N-acyl-hexosamines" RELATED [ChEBI] is_a: CHEBI:24586 ! hexosamine [Term] id: CHEBI:21731 name: N-glycosyl compound namespace: chebi_ontology def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." [] subset: 3_STAR synonym: "glycosylamines" RELATED [IUPAC] synonym: "N-glycoside" RELATED [ChEBI] synonym: "N-glycosides" RELATED [ChEBI] synonym: "N-glycosyl compounds" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:63161 ! glycosyl compound [Term] id: CHEBI:22153 name: acaricide namespace: chebi_ontology def: "A substance used to destroy pests of the subclass Acari (mites and ticks)." [] subset: 3_STAR synonym: "acaricides" RELATED [ChEBI] synonym: "Akarizid" RELATED [ChEBI] synonym: "Akarizide" RELATED [ChEBI] synonym: "miticide" RELATED [ChEBI] xref: Wikipedia:Acaricide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:22160 name: acetamides namespace: chebi_ontology def: "Compounds with the general formula RNHC(=O)CH3." [] subset: 3_STAR is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:22221 name: acyl group namespace: chebi_ontology def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." [] subset: 3_STAR synonym: "acyl group" EXACT [IUPAC] synonym: "acyl groups" RELATED [ChEBI] synonym: "alkanoyl group" RELATED [ChEBI] synonym: "groupe acyle" RELATED [IUPAC] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:22314 name: alkali metal atom namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal" RELATED [ChEBI] synonym: "Alkalimetall" RELATED [ChEBI] synonym: "Alkalimetalle" RELATED [ChEBI] synonym: "metal alcalin" RELATED [ChEBI] synonym: "metal alcalino" RELATED [ChEBI] synonym: "metales alcalinos" RELATED [ChEBI] synonym: "metaux alcalins" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom is_a: CHEBI:33521 ! metal atom is_a: CHEBI:33559 ! s-block element atom [Term] id: CHEBI:22315 name: alkaloid namespace: chebi_ontology def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." [] subset: 3_STAR synonym: "alcaloide" RELATED [ChEBI] synonym: "alcaloides" RELATED [ChEBI] synonym: "Alkaloid" EXACT [ChEBI] synonym: "Alkaloide" RELATED [ChEBI] xref: Wikipedia:Alkaloid is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:22323 name: alkyl group namespace: chebi_ontology def: "A univalent group -CnH2n+1 derived from an alkane by removal of a hydrogen atom from any carbon atom." [] subset: 3_STAR synonym: "groupe alkyle" RELATED [IUPAC] synonym: "grupo alquilo" RELATED [IUPAC] synonym: "grupos alquilo" RELATED [IUPAC] is_a: CHEBI:33248 ! hydrocarbyl group relationship: is_substituent_group_from CHEBI:18310 ! alkane [Term] id: CHEBI:22390 name: alpha-D-glucoside namespace: chebi_ontology subset: 3_STAR synonym: "alpha-D-glucoside" EXACT [ChEBI] synonym: "alpha-D-glucosides" RELATED [ChEBI] synonym: "an alpha-D-glucoside" RELATED [UniProt] is_a: CHEBI:35436 ! D-glucoside is_a: CHEBI:60979 ! alpha-glucoside relationship: has_functional_parent CHEBI:17925 ! alpha-D-glucose [Term] id: CHEBI:22478 name: amino alcohol namespace: chebi_ontology def: "An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group." [] subset: 3_STAR synonym: "amino alcohols" RELATED [ChEBI] synonym: "aminoalcohol" RELATED [ChEBI] synonym: "aminoalcohols" RELATED [ChEBI] is_a: CHEBI:30879 ! alcohol is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:22479 name: amino cyclitol glycoside namespace: chebi_ontology subset: 3_STAR synonym: "amino cyclitol glycoside" EXACT [ChEBI] synonym: "amino cyclitol glycosides" RELATED [ChEBI] is_a: CHEBI:23451 ! cyclitol is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:22494 name: aminobenzoate namespace: chebi_ontology subset: 3_STAR synonym: "aminobenzoates" RELATED [ChEBI] is_a: CHEBI:22718 ! benzoates relationship: is_conjugate_base_of CHEBI:22495 ! aminobenzoic acid [Term] id: CHEBI:22495 name: aminobenzoic acid namespace: chebi_ontology subset: 3_STAR synonym: "Aminobenzoesaeure" RELATED [ChEBI] is_a: CHEBI:22723 ! benzoic acids is_a: CHEBI:33856 ! aromatic amino acid relationship: is_conjugate_acid_of CHEBI:22494 ! aminobenzoate [Term] id: CHEBI:22506 name: aminoglycan namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycans" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:65212 ! polysaccharide derivative [Term] id: CHEBI:22507 name: aminoglycoside antibiotic namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycoside antibiotics" RELATED [ChEBI] is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:47779 ! aminoglycoside [Term] id: CHEBI:22562 name: anilines namespace: chebi_ontology def: "Any aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33860 ! aromatic amine [Term] id: CHEBI:22563 name: anion namespace: chebi_ontology def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." [] subset: 3_STAR synonym: "Anion" EXACT [ChEBI] synonym: "anion" EXACT [ChEBI] synonym: "Anionen" RELATED [ChEBI] synonym: "aniones" RELATED [ChEBI] synonym: "anions" RELATED [IUPAC] is_a: CHEBI:24870 ! ion [Term] id: CHEBI:22565 name: ansamycin namespace: chebi_ontology def: "A class of macrocyclic lactams that consist of an aromatic (phenyl or naphthyl) or quinonoid (benzoquinone or naphthoquinone) moiety that is bridged by an aliphatic chain." [] subset: 3_STAR xref: Wikipedia:Ansamycin is_a: CHEBI:24995 ! lactam is_a: CHEBI:26188 ! polyketide is_a: CHEBI:51026 ! macrocycle [Term] id: CHEBI:22586 name: antioxidant namespace: chebi_ontology def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." [] subset: 3_STAR synonym: "antioxidants" RELATED [ChEBI] synonym: "antioxydant" RELATED [ChEBI] synonym: "antoxidant" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22587 name: antiviral agent namespace: chebi_ontology def: "A substance that destroys or inhibits replication of viruses." [] subset: 3_STAR synonym: "anti-viral agent" RELATED [ChEBI] synonym: "anti-viral agents" RELATED [ChEBI] synonym: "antiviral" RELATED [ChEBI] synonym: "antiviral agents" RELATED [ChEBI] synonym: "antivirals" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:22601 name: arabinoside namespace: chebi_ontology subset: 3_STAR synonym: "arabinoside" EXACT [ChEBI] synonym: "arabinosides" RELATED [ChEBI] is_a: CHEBI:35312 ! pentoside [Term] id: CHEBI:22645 name: arenecarboxamide namespace: chebi_ontology def: "A monocarboxylic acid amide in which the amide linkage is bonded directly to an arene ring system." [] subset: 3_STAR synonym: "arenecarboxamides" RELATED [ChEBI] is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:62733 ! aromatic amide [Term] id: CHEBI:22695 name: base namespace: chebi_ontology def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." [] subset: 3_STAR synonym: "Base" EXACT [ChEBI] synonym: "base" EXACT [ChEBI] synonym: "Base1" RELATED [KEGG_COMPOUND] synonym: "Base2" RELATED [KEGG_COMPOUND] synonym: "Basen" RELATED [ChEBI] synonym: "bases" RELATED [ChEBI] synonym: "Nucleobase" RELATED [KEGG_COMPOUND] xref: KEGG:C00701 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22702 name: benzamides namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22645 ! arenecarboxamide [Term] id: CHEBI:22712 name: benzenes namespace: chebi_ontology def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound [Term] id: CHEBI:22713 name: arenesulfonate oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "arenesulfonates" RELATED [ChEBI] is_a: CHEBI:33554 ! organosulfonate oxoanion relationship: is_conjugate_base_of CHEBI:33555 ! arenesulfonic acid [Term] id: CHEBI:22715 name: benzimidazoles namespace: chebi_ontology def: "An organic heterocyclic compound containing a benzene ring fused to an imidazole ring." [] subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:22718 name: benzoates namespace: chebi_ontology def: "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid." [] subset: 3_STAR synonym: "benzoate anion" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:91007 ! aromatic carboxylate [Term] id: CHEBI:22723 name: benzoic acids namespace: chebi_ontology def: "Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33859 ! aromatic carboxylic acid [Term] id: CHEBI:22727 name: benzopyran namespace: chebi_ontology subset: 3_STAR synonym: "benzopyrans" RELATED [ChEBI] xref: Wikipedia:Benzopyran is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:22728 name: benzopyrrole namespace: chebi_ontology subset: 3_STAR synonym: "benzopyrroles" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38180 ! polycyclic heteroarene [Term] id: CHEBI:228364 name: NMR chemical shift reference compound namespace: chebi_ontology def: "Any compound that produces a peak used as reference frequency in the delta chemical shift scale." [] subset: 3_STAR synonym: "NMR chemical shift reference compounds" RELATED [ChEBI] synonym: "NMR chemical shift standard" RELATED [ChEBI] synonym: "NMR chemical shift standards" RELATED [ChEBI] synonym: "NMR internal standard" RELATED [ChEBI] synonym: "NMR internal standards" RELATED [ChEBI] synonym: "NMR reference standard" RELATED [ChEBI] synonym: "NMR reference standards" RELATED [ChEBI] is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:22888 name: biphenyls namespace: chebi_ontology def: "Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound is_a: CHEBI:36820 ! ring assembly is_a: CHEBI:64459 ! biaryl [Term] id: CHEBI:22907 name: bleomycin namespace: chebi_ontology alt_id: CHEBI:584977 def: "A glycopeptide produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2." [] subset: 3_STAR xref: DrugBank:DB00290 xref: Wikipedia:Bleomycin is_a: CHEBI:23089 ! chelate-forming peptide is_a: CHEBI:24396 ! glycopeptide [Term] id: CHEBI:22917 name: phytogenic insecticide namespace: chebi_ontology def: "An insecticide compound naturally occurring in plants." [] subset: 3_STAR synonym: "botanical insecticide" RELATED [ChEBI] synonym: "botanical insecticides" RELATED [ChEBI] synonym: "phytogenic insecticides" RELATED [ChEBI] is_a: CHEBI:24852 ! insecticide [Term] id: CHEBI:22944 name: butanediols namespace: chebi_ontology def: "A diol that is a butanediol or a derivative of a butanediol." [] subset: 3_STAR is_a: CHEBI:23824 ! diol [Term] id: CHEBI:229543 name: sulbactam(1-) namespace: chebi_ontology def: "A monocarboxylic acid anion that is the conjugate base of sulbactam resulting from the deprotonation of the carboxy group; Major species at pH 7.3." [] subset: 3_STAR synonym: "sulbactam anion" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:9321 ! sulbactam [Term] id: CHEBI:22986 name: calcium ionophore namespace: chebi_ontology subset: 3_STAR synonym: "calcium ionophores" RELATED [ChEBI] is_a: CHEBI:24869 ! ionophore [Term] id: CHEBI:23003 name: carbamate ester namespace: chebi_ontology def: "Any ester of carbamic acid or its N-substituted derivatives." [] subset: 3_STAR synonym: "carbamate esters" RELATED [ChEBI] synonym: "carbamates" RELATED [ChEBI] xref: Wikipedia:Carbamate is_a: CHEBI:33308 ! carboxylic ester relationship: has_functional_parent CHEBI:28616 ! carbamic acid [Term] id: CHEBI:23004 name: carbamoyl group namespace: chebi_ontology def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." [] subset: 3_STAR synonym: "-C(O)NH2" RELATED [ChEBI] synonym: "-CONH2" RELATED [IUPAC] synonym: "aminocarbonyl" RELATED [IUPAC] synonym: "carbamyl" RELATED [ChEBI] synonym: "carbamyl group" RELATED [ChEBI] synonym: "carboxamide" RELATED [IUPAC] is_a: CHEBI:27207 ! univalent carboacyl group relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid [Term] id: CHEBI:23007 name: carbohydrate-containing antibiotic namespace: chebi_ontology def: "Any carbohydrate derivative that exhibits antibiotic activity." [] subset: 3_STAR is_a: CHEBI:63299 ! carbohydrate derivative relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:23018 name: EC 4.2.1.1 (carbonic anhydrase) inhibitor namespace: chebi_ontology def: "An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule." [] subset: 3_STAR synonym: "anhydrase inhibitor" RELATED [ChEBI] synonym: "anhydrase inhibitors" RELATED [ChEBI] synonym: "carbonate anhydrase inhibitor" RELATED [ChEBI] synonym: "carbonate anhydrase inhibitors" RELATED [ChEBI] synonym: "carbonate dehydratase inhibitor" RELATED [ChEBI] synonym: "carbonate dehydratase inhibitors" RELATED [ChEBI] synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitor" RELATED [ChEBI] synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitors" RELATED [ChEBI] synonym: "carbonate hydro-lyase inhibitor" RELATED [ChEBI] synonym: "carbonate hydro-lyase inhibitors" RELATED [ChEBI] synonym: "carbonic acid anhydrase inhibitor" RELATED [ChEBI] synonym: "carbonic acid anhydrase inhibitors" RELATED [ChEBI] synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitor" RELATED [ChEBI] synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitors" RELATED [ChEBI] synonym: "carbonic anhydrase A inhibitor" RELATED [ChEBI] synonym: "carbonic anhydrase A inhibitors" RELATED [ChEBI] synonym: "carbonic anhydrase inhibitor" RELATED [ChEBI] synonym: "carbonic anhydrase inhibitors" RELATED [ChEBI] synonym: "carboxyanhydrase inhibitor" RELATED [ChEBI] synonym: "carboxyanhydrase inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.1 (carbonic anhydrase) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.1 inhibitor" RELATED [ChEBI] synonym: "EC 4.2.1.1 inhibitors" RELATED [ChEBI] xref: Wikipedia:Carbonic_anhydrase_inhibitor is_a: CHEBI:76907 ! EC 4.2.1.* (hydro-lyases) inhibitor [Term] id: CHEBI:23019 name: carbonyl group namespace: chebi_ontology subset: 3_STAR synonym: ">C=O" RELATED [IUPAC] synonym: "carbonyl group" EXACT [ChEBI, UniProt] is_a: CHEBI:51422 ! organodiyl group [Term] id: CHEBI:230471 name: EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitor namespace: chebi_ontology def: "A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of 1,3-beta-glucan synthase (EC 2.4.1.34)." [] subset: 3_STAR synonym: "(1,3)-beta-glucan (callose) synthase inhibitor" RELATED [ChEBI] synonym: "(1,3)-beta-glucan (callose) synthase inhibitors" RELATED [ChEBI] synonym: "1,3-beta-D-glucan synthase inhibitor" RELATED [ChEBI] synonym: "1,3-beta-D-glucan synthase inhibitors" RELATED [ChEBI] synonym: "1,3-beta-D-glucan synthetase inhibitor" RELATED [ChEBI] synonym: "1,3-beta-D-glucan synthetase inhibitors" RELATED [ChEBI] synonym: "1,3-beta-D-glucan--UDP glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "1,3-beta-D-glucan--UDP glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "1,3-beta-glucan synthase inhibitor" RELATED [ChEBI] synonym: "1,3-beta-glucan synthase inhibitors" RELATED [ChEBI] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase inhibitor" RELATED [ChEBI] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase inhibitors" RELATED [ChEBI] synonym: "beta-1,3-glucan synthase inhibitor" RELATED [ChEBI] synonym: "beta-1,3-glucan synthase inhibitors" RELATED [ChEBI] synonym: "beta-1,3-glucan synthetase inhibitor" RELATED [ChEBI] synonym: "beta-1,3-glucan synthetase inhibitors" RELATED [ChEBI] synonym: "callose synthase inhibitor" RELATED [ChEBI] synonym: "callose synthase inhibitors" RELATED [ChEBI] synonym: "callose synthetase inhibitor" RELATED [ChEBI] synonym: "callose synthetase inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.34 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.34 inhibitors" RELATED [ChEBI] synonym: "GS-II inhibitor" RELATED [ChEBI] synonym: "GS-II inhibitors" RELATED [ChEBI] synonym: "paramylon synthetase inhibitor" RELATED [ChEBI] synonym: "paramylon synthetase inhibitors" RELATED [ChEBI] synonym: "UDP-glucose--1,3-beta-D-glucan glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-glucose--1,3-beta-D-glucan glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-glucose-beta-glucan glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-glucose-beta-glucan glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-glucose:(1,3)beta-glucan synthase inhibitor" RELATED [ChEBI] synonym: "UDP-glucose:(1,3)beta-glucan synthase inhibitors" RELATED [ChEBI] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase inhibitors" RELATED [ChEBI] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase inhibitor" RELATED [ChEBI] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:1\,3-Beta-glucan_synthase is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor [Term] id: CHEBI:23066 name: cephalosporin namespace: chebi_ontology alt_id: CHEBI:3538 def: "A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy." [] subset: 3_STAR synonym: "cephalosphorin" RELATED [ChEBI] synonym: "cephalosphorins" RELATED [ChEBI] synonym: "Cephalosporin" EXACT [KEGG_COMPOUND] synonym: "cephalosporins" RELATED [ChEBI] xref: KEGG:C00875 xref: Wikipedia:Cephalosporin is_a: CHEBI:38311 ! cephem relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:23089 name: chelate-forming peptide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25903 ! peptide antibiotic relationship: RO:0000087 CHEBI:38161 ! has role chelator [Term] id: CHEBI:23114 name: chloride salt namespace: chebi_ontology subset: 3_STAR synonym: "chloride salts" RELATED [ChEBI] synonym: "chlorides" RELATED [ChEBI] is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:33958 ! halide salt relationship: BFO:0000051 CHEBI:17996 ! has part chloride [Term] id: CHEBI:23116 name: chlorine atom namespace: chebi_ontology subset: 3_STAR synonym: "17Cl" RELATED [IUPAC] synonym: "Chlor" RELATED [ChEBI] synonym: "chlore" RELATED [ChEBI] synonym: "chlorine" RELATED [ChEBI] synonym: "chlorum" RELATED [ChEBI] synonym: "Cl" RELATED [IUPAC] synonym: "cloro" RELATED [ChEBI] xref: WebElements:Cl is_a: CHEBI:24473 ! halogen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient [Term] id: CHEBI:23117 name: chlorine molecular entity namespace: chebi_ontology def: "A halogen molecular entity containing one or more atoms of chlorine." [] subset: 3_STAR is_a: CHEBI:24471 ! halogen molecular entity relationship: BFO:0000051 CHEBI:23116 ! has part chlorine atom [Term] id: CHEBI:23132 name: chlorobenzenes namespace: chebi_ontology def: "Any organochlorine compound containing a benzene ring which is substituted by one or more chlorines." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:36683 ! organochlorine compound [Term] id: CHEBI:231550 name: azithromycin(2+) namespace: chebi_ontology def: "A tertiary ammonium ion resulting from the protonation of the two amino groups of azithromycin; major species at pH 7.3." [] subset: 3_STAR synonym: "azithromycin dication" RELATED [ChEBI] is_a: CHEBI:137982 ! tertiary ammonium ion relationship: is_conjugate_acid_of CHEBI:2955 ! azithromycin [Term] id: CHEBI:231553 name: levofloxacin(1-) namespace: chebi_ontology def: "An oxo monocarboxylic acid anion that is the conjugate base of levofloxacin resulting from the deprotonation of the carboxy group; major species at pH 7.3." [] subset: 3_STAR synonym: "levofloxacin anion" RELATED [ChEBI] is_a: CHEBI:35902 ! oxo monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:63598 ! levofloxacin [Term] id: CHEBI:23213 name: choline ester namespace: chebi_ontology alt_id: CHEBI:3666 subset: 3_STAR synonym: "choline esters" RELATED [ChEBI] is_a: CHEBI:35701 ! ester relationship: has_functional_parent CHEBI:15354 ! choline [Term] id: CHEBI:23217 name: cholines namespace: chebi_ontology def: "A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof." [] subset: 3_STAR is_a: CHEBI:35267 ! quaternary ammonium ion [Term] id: CHEBI:23232 name: chromenes namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38443 ! 1-benzopyran [Term] id: CHEBI:23239 name: chromopeptide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25903 ! peptide antibiotic [Term] id: CHEBI:233202 name: paromomycin(5+) namespace: chebi_ontology subset: 2_STAR synonym: "paromomycin" RELATED [UniProt] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:7934 ! paromomycin [Term] id: CHEBI:23357 name: cofactor namespace: chebi_ontology def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." [] subset: 3_STAR synonym: "cofactor" EXACT [IUPAC] xref: Wikipedia:Cofactor_(biochemistry) is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:23366 name: compatible osmolytes namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25728 ! osmolyte [Term] id: CHEBI:23367 name: molecular entity namespace: chebi_ontology def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] subset: 3_STAR synonym: "entidad molecular" RELATED [IUPAC] synonym: "entidades moleculares" RELATED [IUPAC] synonym: "entite moleculaire" RELATED [IUPAC] synonym: "molecular entities" RELATED [IUPAC] synonym: "molekulare Entitaet" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:23377 name: copper molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "copper compounds" RELATED [ChEBI] synonym: "copper molecular entities" RELATED [ChEBI] synonym: "copper molecular entity" EXACT [ChEBI] is_a: CHEBI:33745 ! copper group molecular entity relationship: BFO:0000051 CHEBI:28694 ! has part copper atom [Term] id: CHEBI:23378 name: copper cation namespace: chebi_ontology subset: 3_STAR synonym: "copper cations" RELATED [ChEBI] synonym: "Cu cation" RELATED [UniProt] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:37404 ! elemental copper relationship: RO:0000087 CHEBI:23357 ! has role cofactor [Term] id: CHEBI:23403 name: coumarins namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26004 ! phenylpropanoid is_a: CHEBI:38445 ! chromenone [Term] id: CHEBI:23414 name: copper(II) sulfate namespace: chebi_ontology def: "A metal sulfate compound having copper(2+) as the metal ion." [] subset: 3_STAR synonym: "copper sulfate" RELATED [ChemIDplus] synonym: "Copper(II) sulfate" EXACT [KEGG_COMPOUND] synonym: "Cupric sulfate" RELATED [ChemIDplus] synonym: "cupric sulfate anhydrous" RELATED [ChemIDplus] synonym: "CuSO4" RELATED [IUPAC] xref: KEGG:C18713 xref: PPDB:178 xref: Wikipedia:Copper(II)_sulfate is_a: CHEBI:51336 ! metal sulfate relationship: BFO:0000051 CHEBI:29036 ! has part copper(2+) relationship: RO:0000087 CHEBI:139492 ! has role sensitiser relationship: RO:0000087 CHEBI:149552 ! has role emetic relationship: RO:0000087 CHEBI:33287 ! has role fertilizer [Term] id: CHEBI:23424 name: cyanides namespace: chebi_ontology def: "Salts and C-organyl derivatives of hydrogen cyanide, HC#N." [] subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:18407 ! hydrogen cyanide [Term] id: CHEBI:23443 name: cyclic amide namespace: chebi_ontology alt_id: CHEBI:3990 subset: 3_STAR synonym: "cyclic amide" EXACT [ChEBI] synonym: "cyclic amides" RELATED [ChEBI] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:23447 name: cyclic nucleotide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic nucleotides" RELATED [ChEBI] is_a: CHEBI:36976 ! nucleotide [Term] id: CHEBI:23449 name: cyclic peptide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic peptides" RELATED [ChEBI] synonym: "Cyclopeptid" RELATED [ChEBI] synonym: "peptide cyclique" RELATED [IUPAC] synonym: "peptido ciclico" RELATED [IUPAC] synonym: "Zyklopeptid" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:23451 name: cyclitol namespace: chebi_ontology def: "A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom." [] subset: 3_STAR is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:23503 name: 4-amino-1,2-oxazolidin-3-one namespace: chebi_ontology def: "A member of the class of oxazolidines that is isoxazoldin-3-one which is substituted at position 4 by an amino group." [] subset: 3_STAR synonym: "cycloserine" RELATED [ChEBI] xref: KEGG:C06682 is_a: CHEBI:26649 ! serine derivative is_a: CHEBI:38329 ! oxazolidines is_a: CHEBI:50994 ! primary amino compound is_a: CHEBI:75606 ! hydroxamic acid ester [Term] id: CHEBI:23636 name: deoxyribonucleoside namespace: chebi_ontology subset: 3_STAR synonym: "deoxyribonucleosides" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside [Term] id: CHEBI:23643 name: depsipeptide namespace: chebi_ontology def: "A natural or synthetic compound having a sequence of amino and hydroxy carboxylic acid residues (usually alpha-amino and alpha-hydroxy acids), commonly but not necessarily regularly alternating." [] subset: 3_STAR synonym: "Depsipeptid" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:23666 name: diamine namespace: chebi_ontology def: "Any polyamine that contains two amino groups." [] subset: 3_STAR is_a: CHEBI:88061 ! polyamine [Term] id: CHEBI:23677 name: diazole namespace: chebi_ontology def: "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." [] subset: 3_STAR synonym: "diazoles" RELATED [ChEBI] is_a: CHEBI:68452 ! azole [Term] id: CHEBI:23697 name: dichlorobenzene namespace: chebi_ontology def: "Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions." [] subset: 3_STAR synonym: "Dichlorbenzol" RELATED [ChEBI] synonym: "dichlorobenzene" EXACT [ChEBI] synonym: "dichlorobenzenes" RELATED [ChEBI] is_a: CHEBI:23132 ! chlorobenzenes [Term] id: CHEBI:23763 name: pyrroline namespace: chebi_ontology def: "Any organic heteromonocyclic compound with a structure based on a dihydropyrrole." [] subset: 3_STAR synonym: "dihydropyrrole" RELATED [ChemIDplus] synonym: "pyrroline" EXACT [ChemIDplus] synonym: "pyrrolines" RELATED [ChEBI] xref: Wikipedia:Pyrroline is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:23765 name: quinolone namespace: chebi_ontology subset: 3_STAR synonym: "quinolones" RELATED [ChEBI] is_a: CHEBI:26513 ! quinolines [Term] id: CHEBI:23824 name: diol namespace: chebi_ontology def: "A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols." [] subset: 3_STAR xref: Wikipedia:Diol is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:23849 name: diterpenoid namespace: chebi_ontology def: "Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." [] subset: 3_STAR synonym: "C20 isoprenoids" RELATED [LIPID_MAPS] synonym: "diterpenoides" RELATED [ChEBI] is_a: CHEBI:26873 ! terpenoid relationship: has_parent_hydride CHEBI:35190 ! diterpene [Term] id: CHEBI:23853 name: dithiol namespace: chebi_ontology subset: 3_STAR synonym: "dithiols" RELATED [ChEBI] is_a: CHEBI:29256 ! thiol [Term] id: CHEBI:23870 name: dodecyl group namespace: chebi_ontology subset: 3_STAR synonym: "CH3-[CH2]11-" RELATED [IUPAC] synonym: "Dod" RELATED [CBN] synonym: "dodecan-1-yl" RELATED [ChEBI] synonym: "lauryl" RELATED [ChEBI] is_a: CHEBI:22323 ! alkyl group relationship: is_substituent_group_from CHEBI:28817 ! dodecane [Term] id: CHEBI:23872 name: dodecyl sulfate namespace: chebi_ontology subset: 3_STAR synonym: "dodecyl sulfate" EXACT [UniProt] xref: DrugBank:DB03967 is_a: CHEBI:58958 ! organosulfate oxoanion relationship: is_conjugate_base_of CHEBI:45599 ! dodecyl hydrogen sulfate relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic [Term] id: CHEBI:23888 name: drug namespace: chebi_ontology def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." [] subset: 3_STAR synonym: "drugs" RELATED [ChEBI] synonym: "medicine" RELATED [ChEBI] is_a: CHEBI:52217 ! pharmaceutical [Term] id: CHEBI:23905 name: monoatomic anion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:24867 ! monoatomic ion [Term] id: CHEBI:23906 name: monoatomic cation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic cations" RELATED [ChEBI] is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:23924 name: enzyme inhibitor namespace: chebi_ontology def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." [] subset: 3_STAR synonym: "enzyme inhibitors" RELATED [ChEBI] synonym: "inhibidor enzimatico" RELATED [ChEBI] synonym: "inhibidores enzimaticos" RELATED [ChEBI] synonym: "inhibiteur enzymatique" RELATED [ChEBI] synonym: "inhibiteurs enzymatiques" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:23953 name: erythromycins namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25105 ! macrolide antibiotic relationship: has_functional_parent CHEBI:23955 ! erythronolide [Term] id: CHEBI:23955 name: erythronolide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:23981 name: ethanolamines namespace: chebi_ontology subset: 3_STAR synonym: "ethanolamine" RELATED [ChEBI] is_a: CHEBI:22478 ! amino alcohol [Term] id: CHEBI:24061 name: fluorine atom namespace: chebi_ontology subset: 3_STAR synonym: "9F" RELATED [IUPAC] synonym: "F" RELATED [IUPAC] synonym: "Fluor" RELATED [ChemIDplus] synonym: "fluor" RELATED [ChEBI] synonym: "fluorine" RELATED [ChEBI] synonym: "fluorum" RELATED [ChEBI] xref: WebElements:F is_a: CHEBI:24473 ! halogen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient [Term] id: CHEBI:24062 name: fluorine molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "fluorine compounds" RELATED [ChEBI] synonym: "fluorine molecular entities" RELATED [ChEBI] synonym: "fluorine molecular entity" EXACT [ChEBI] is_a: CHEBI:24471 ! halogen molecular entity relationship: BFO:0000051 CHEBI:24061 ! has part fluorine atom [Term] id: CHEBI:24068 name: fluoroamino acid namespace: chebi_ontology def: "An organofluorine compound that consists of an amino acid substituted by a fluoro group." [] subset: 3_STAR synonym: "fluoroamino acids" RELATED [ChEBI] is_a: CHEBI:24470 ! haloamino acid is_a: CHEBI:37143 ! organofluorine compound [Term] id: CHEBI:24079 name: formamides namespace: chebi_ontology def: "Amides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H)." [] subset: 3_STAR is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:24127 name: fungicide namespace: chebi_ontology def: "A substance used to destroy fungal pests." [] subset: 3_STAR synonym: "fungicides" RELATED [ChEBI] is_a: CHEBI:25944 ! pesticide is_a: CHEBI:35718 ! antifungal agent [Term] id: CHEBI:24129 name: furans namespace: chebi_ontology def: "Compounds containing at least one furan ring." [] subset: 3_STAR synonym: "oxacyclopenta-2,4-dienes" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:24271 name: glucosamines namespace: chebi_ontology def: "Any hexosamine that is glucose in which at least one of the hydroxy groups has been replaced by an amino group." [] subset: 3_STAR is_a: CHEBI:24586 ! hexosamine [Term] id: CHEBI:24278 name: glucoside namespace: chebi_ontology subset: 3_STAR synonym: "glucosides" RELATED [ChEBI] is_a: CHEBI:35313 ! hexoside [Term] id: CHEBI:24318 name: glutamine family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." [] subset: 3_STAR synonym: "glutamine family amino acids" RELATED [ChEBI] is_a: CHEBI:15705 ! L-alpha-amino acid is_a: CHEBI:83813 ! proteinogenic amino acid [Term] id: CHEBI:24396 name: glycopeptide namespace: chebi_ontology alt_id: CHEBI:24395 alt_id: CHEBI:5478 def: "Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide." [] subset: 3_STAR is_a: CHEBI:16670 ! peptide is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:24400 name: glycoside namespace: chebi_ontology def: "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively." [] subset: 3_STAR synonym: "glycosides" RELATED [ChEBI] synonym: "O-glycoside" RELATED [ChEBI] synonym: "O-glycosides" RELATED [ChEBI] is_a: CHEBI:63161 ! glycosyl compound [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] subset: 3_STAR synonym: "chemical entity" EXACT [UniProt] is_a: BFO:0000040 ! material entity [Term] id: CHEBI:24432 name: biological role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a biological context." [] subset: 3_STAR synonym: "biological function" RELATED [ChEBI] is_a: CHEBI:50906 ! role [Term] id: CHEBI:24433 name: group namespace: chebi_ontology def: "A defined linked collection of atoms or a single atom within a molecular entity." [] subset: 3_STAR synonym: "groupe" RELATED [IUPAC] synonym: "grupo" RELATED [IUPAC] synonym: "grupos" RELATED [IUPAC] synonym: "Gruppe" RELATED [ChEBI] synonym: "Rest" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: BFO:0000051 CHEBI:33250 ! has part atom [Term] id: CHEBI:24436 name: guanidines namespace: chebi_ontology def: "Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas." [] subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:24470 name: haloamino acid namespace: chebi_ontology def: "Any non-proteinogenic amino acid carrying at least one halo group." [] subset: 3_STAR synonym: "haloamino acids" RELATED [ChEBI] is_a: CHEBI:83820 ! non-proteinogenic amino acid [Term] id: CHEBI:24471 name: halogen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "halogen compounds" RELATED [ChEBI] synonym: "halogen molecular entities" RELATED [ChEBI] synonym: "halogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: BFO:0000051 CHEBI:24473 ! has part halogen [Term] id: CHEBI:24473 name: halogen namespace: chebi_ontology subset: 3_STAR synonym: "group 17 elements" RELATED [ChEBI] synonym: "group VII elements" RELATED [ChEBI] synonym: "Halogene" RELATED [ChEBI] synonym: "halogene" RELATED [ChEBI] synonym: "halogenes" RELATED [ChEBI] synonym: "halogeno" RELATED [ChEBI] synonym: "halogenos" RELATED [ChEBI] is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:24531 name: heterocyclic antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24532 ! organic heterocyclic compound relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:24532 name: organic heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." [] subset: 3_STAR synonym: "organic heterocycle" RELATED [ChEBI] synonym: "organic heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33832 ! organic cyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:24533 name: heterodetic cyclic peptide namespace: chebi_ontology def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." [] subset: 3_STAR synonym: "heterodetic cyclic peptides" RELATED [ChEBI] synonym: "peptide cyclique heterodetique" RELATED [IUPAC] synonym: "peptido ciclico heterodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide [Term] id: CHEBI:24583 name: hexitol namespace: chebi_ontology subset: 3_STAR synonym: "hexitol" EXACT [ChEBI] synonym: "hexitols" RELATED [ChEBI] is_a: CHEBI:17522 ! alditol [Term] id: CHEBI:24586 name: hexosamine namespace: chebi_ontology def: "Any 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group." [] subset: 3_STAR synonym: "hexosamine" EXACT [ChEBI] synonym: "hexosamines" RELATED [ChEBI] is_a: CHEBI:60926 ! amino monosaccharide [Term] id: CHEBI:24613 name: homodetic cyclic peptide namespace: chebi_ontology def: "A homodetic cyclic peptide is a cyclic peptide in which the ring consists solely of amino-acid residues in peptide linkages." [] subset: 3_STAR synonym: "homodetic cyclic peptides" RELATED [ChEBI] synonym: "peptide cyclique homodetique" RELATED [IUPAC] synonym: "peptido ciclico homodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide [Term] id: CHEBI:24621 name: hormone namespace: chebi_ontology def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." [] subset: 3_STAR synonym: "endocrine" RELATED [ChEBI] synonym: "hormones" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:24628 name: imidazolidine-2,4-dione namespace: chebi_ontology def: "An imidazolidinone with oxo groups at position 2 and 4." [] subset: 3_STAR is_a: CHEBI:55370 ! imidazolidinone [Term] id: CHEBI:24632 name: hydrocarbon namespace: chebi_ontology def: "A compound consisting of carbon and hydrogen only." [] subset: 3_STAR synonym: "hidrocarburo" RELATED [IUPAC] synonym: "hidrocarburos" RELATED [IUPAC] synonym: "hydrocarbure" RELATED [IUPAC] synonym: "Kohlenwasserstoff" RELATED [ChEBI] synonym: "Kohlenwasserstoffe" RELATED [ChEBI] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:24648 name: hydroxamic acid anion namespace: chebi_ontology def: "An oxoanion resulting from the removal of a proton from the hydroxy group of any hydroxamic acid." [] subset: 3_STAR synonym: "hydroxamate" RELATED [ChEBI] synonym: "hydroxamates" RELATED [ChEBI] synonym: "hydroxamic acid anions" RELATED [ChEBI] synonym: "hydroxamic anion" RELATED [ChEBI] synonym: "hydroxamic anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion relationship: is_conjugate_base_of CHEBI:24650 ! hydroxamic acid [Term] id: CHEBI:24650 name: hydroxamic acid namespace: chebi_ontology def: "A compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides." [] subset: 3_STAR synonym: "hydroxamic acids" RELATED [ChEBI] synonym: "N-hydroxy amide" RELATED [ChEBI] synonym: "N-hydroxy amides" RELATED [ChEBI] synonym: "N-hydroxy-amide" RELATED [ChEBI] synonym: "N-hydroxy-amides" RELATED [ChEBI] synonym: "N-hydroxyamide" RELATED [ChEBI] synonym: "N-hydroxyamides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide relationship: is_conjugate_acid_of CHEBI:24648 ! hydroxamic acid anion [Term] id: CHEBI:24651 name: hydroxides namespace: chebi_ontology def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." [] subset: 3_STAR is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: BFO:0000051 CHEBI:43176 ! has part hydroxy group [Term] id: CHEBI:24654 name: hydroxy fatty acid namespace: chebi_ontology def: "Any fatty acid carrying one or more hydroxy substituents." [] subset: 3_STAR synonym: "hydroxy fatty acids" RELATED [LIPID_MAPS] is_a: CHEBI:35366 ! fatty acid is_a: CHEBI:35868 ! hydroxy monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:59835 ! hydroxy fatty acid anion [Term] id: CHEBI:24669 name: hydroxy carboxylic acid namespace: chebi_ontology def: "Any carboxylic acid with at least one hydroxy group." [] subset: 3_STAR synonym: "hydroxy carboxylic acids" RELATED [ChEBI] synonym: "hydroxycarboxylic acid" RELATED [ChEBI] synonym: "hydroxycarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:24675 name: hydroxybenzoate namespace: chebi_ontology def: "Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent." [] subset: 3_STAR synonym: "hydroxybenzoates" RELATED [ChEBI] is_a: CHEBI:22718 ! benzoates is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:24676 ! hydroxybenzoic acid [Term] id: CHEBI:24676 name: hydroxybenzoic acid namespace: chebi_ontology alt_id: CHEBI:50778 def: "Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring." [] subset: 3_STAR synonym: "hydroxybenzoic acids" RELATED [ChEBI] is_a: CHEBI:22723 ! benzoic acids is_a: CHEBI:33853 ! phenols relationship: has_functional_parent CHEBI:30746 ! benzoic acid relationship: is_conjugate_acid_of CHEBI:24675 ! hydroxybenzoate [Term] id: CHEBI:2468 name: secondary alpha-hydroxy ketone namespace: chebi_ontology def: "An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary alpha-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups." [] subset: 3_STAR synonym: "acyloin" RELATED [ChEBI] synonym: "acyloins" RELATED [ChEBI] synonym: "secondary alpha-hydroxy ketones" RELATED [ChEBI] synonym: "secondary alpha-hydroxy-ketone" RELATED [ChEBI] synonym: "secondary alpha-hydroxy-ketones" RELATED [ChEBI] synonym: "secondary alpha-hydroxyketone" RELATED [ChEBI] synonym: "secondary alpha-hydroxyketones" RELATED [ChEBI] xref: Wikipedia:Acyloin is_a: CHEBI:139588 ! alpha-hydroxy ketone is_a: CHEBI:35681 ! secondary alcohol [Term] id: CHEBI:24712 name: hydroxymethyl group namespace: chebi_ontology subset: 3_STAR synonym: "-CH2-OH" RELATED [IUPAC] synonym: "serine side-chain" RELATED [ChEBI] is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group relationship: is_substituent_group_from CHEBI:17790 ! methanol [Term] id: CHEBI:24753 name: hygromycin namespace: chebi_ontology subset: 3_STAR synonym: "hygromycins" RELATED [ChEBI] is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:24780 name: imidazoles namespace: chebi_ontology def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [] subset: 3_STAR is_a: CHEBI:23677 ! diazole [Term] id: CHEBI:24782 name: imide namespace: chebi_ontology subset: 3_STAR synonym: "imide" EXACT [ChEBI] synonym: "imides" RELATED [ChEBI] is_a: CHEBI:33257 ! secondary amide [Term] id: CHEBI:24797 name: indole phytoalexin namespace: chebi_ontology subset: 3_STAR synonym: "indole phytoalexins" RELATED [ChEBI] is_a: CHEBI:24828 ! indoles relationship: RO:0000087 CHEBI:26115 ! has role phytoalexin [Term] id: CHEBI:24828 name: indoles namespace: chebi_ontology def: "Any compound containing an indole skeleton." [] subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole [Term] id: CHEBI:24833 name: oxoacid namespace: chebi_ontology def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] subset: 3_STAR synonym: "oxacids" RELATED [ChEBI] synonym: "oxiacids" RELATED [ChEBI] synonym: "oxo acid" RELATED [ChEBI] synonym: "oxy-acids" RELATED [ChEBI] synonym: "oxyacids" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid [Term] id: CHEBI:24834 name: inorganic anion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36914 ! inorganic ion [Term] id: CHEBI:24835 name: inorganic molecular entity namespace: chebi_ontology def: "A molecular entity that contains no carbon." [] subset: 3_STAR synonym: "anorganische Verbindungen" RELATED [ChEBI] synonym: "inorganic compounds" RELATED [ChEBI] synonym: "inorganic entity" RELATED [ChEBI] synonym: "inorganic molecular entities" RELATED [ChEBI] synonym: "inorganics" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24836 name: inorganic oxide namespace: chebi_ontology subset: 3_STAR synonym: "inorganic oxides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25741 ! oxide [Term] id: CHEBI:24837 name: inorganic peroxide namespace: chebi_ontology def: "Compounds of structure ROOR' in which R and R' are inorganic groups." [] subset: 3_STAR synonym: "inorganic peroxide" EXACT [ChEBI] synonym: "inorganic peroxides" RELATED [ChEBI] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:25940 ! peroxides [Term] id: CHEBI:24839 name: inorganic salt namespace: chebi_ontology subset: 3_STAR synonym: "anorganisches Salz" RELATED [ChEBI] synonym: "inorganic salts" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24840 name: inorganic sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "inorganic sulfate salts" RELATED [ChEBI] synonym: "inorganic sulfates" RELATED [ChEBI] is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:35175 ! sulfate salt [Term] id: CHEBI:24848 name: inositol namespace: chebi_ontology def: "Any cyclohexane-1,2,3,4,5,6-hexol." [] subset: 3_STAR synonym: "1,2,3,4,5,6-cyclohexanehexol" RELATED [ChEBI] synonym: "inositol" EXACT [IUBMB] synonym: "inositols" RELATED [ChEBI] is_a: CHEBI:23451 ! cyclitol is_a: CHEBI:37206 ! hexol [Term] id: CHEBI:24852 name: insecticide namespace: chebi_ontology def: "Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects." [] subset: 3_STAR synonym: "insecticides" RELATED [ChEBI] xref: Wikipedia:Insecticide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:24859 name: iodine atom namespace: chebi_ontology def: "Chemical element with atomic number 53." [] subset: 3_STAR synonym: "53I" RELATED [IUPAC] synonym: "I" RELATED [ChEBI] synonym: "Iod" RELATED [ChEBI] synonym: "iode" RELATED [ChEBI] synonym: "iodine" RELATED [ChEBI] synonym: "iodium" RELATED [ChEBI] synonym: "J" RELATED [ChEBI] synonym: "Jod" RELATED [ChEBI] synonym: "yodo" RELATED [ChEBI] xref: WebElements:I is_a: CHEBI:24473 ! halogen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:24860 name: iodine molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "iodine compounds" RELATED [ChEBI] synonym: "iodine molecular entities" RELATED [ChEBI] synonym: "iodine molecular entity" EXACT [ChEBI] is_a: CHEBI:24471 ! halogen molecular entity relationship: BFO:0000051 CHEBI:24859 ! has part iodine atom [Term] id: CHEBI:24866 name: salt namespace: chebi_ontology def: "A salt is an assembly of cations and anions." [] subset: 3_STAR synonym: "ionic compound" RELATED [ChEBI] synonym: "ionic compounds" RELATED [ChEBI] synonym: "sal" RELATED [ChEBI] synonym: "sales" RELATED [ChEBI] synonym: "salts" RELATED [ChEBI] synonym: "Salz" RELATED [ChEBI] synonym: "Salze" RELATED [ChEBI] synonym: "sel" RELATED [ChEBI] synonym: "sels" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: BFO:0000051 CHEBI:22563 ! has part anion relationship: BFO:0000051 CHEBI:36916 ! has part cation [Term] id: CHEBI:24867 name: monoatomic ion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:24868 name: organic salt namespace: chebi_ontology subset: 3_STAR synonym: "organic salts" RELATED [ChEBI] synonym: "organisches Salz" RELATED [ChEBI] is_a: CHEBI:24866 ! salt [Term] id: CHEBI:24869 name: ionophore namespace: chebi_ontology def: "A compound which can carry specific ions through membranes of cells or organelles." [] subset: 3_STAR synonym: "ionophores" RELATED [ChEBI] xref: Wikipedia:Ionophore is_a: CHEBI:38632 ! membrane transport modulator [Term] id: CHEBI:24870 name: ion namespace: chebi_ontology def: "A molecular entity having a net electric charge." [] subset: 3_STAR synonym: "Ion" EXACT [ChEBI] synonym: "ion" EXACT [ChEBI] synonym: "Ionen" RELATED [ChEBI] synonym: "iones" RELATED [ChEBI] synonym: "ions" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:24897 name: isoindoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole [Term] id: CHEBI:24913 name: isoprenoid namespace: chebi_ontology def: "Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives." [] subset: 3_STAR synonym: "isoprenoid" EXACT [ChEBI] synonym: "isoprenoids" RELATED [ChEBI] is_a: CHEBI:18059 ! lipid [Term] id: CHEBI:24951 name: kanamycins namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:24995 name: lactam namespace: chebi_ontology def: "Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [] subset: 3_STAR synonym: "lactam" EXACT [IUPAC] synonym: "lactams" RELATED [ChEBI] synonym: "Laktam" RELATED [ChEBI] synonym: "Laktame" RELATED [ChEBI] is_a: CHEBI:23443 ! cyclic amide is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:25000 name: lactone namespace: chebi_ontology def: "Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [] subset: 3_STAR synonym: "Lacton" RELATED [ChEBI] synonym: "lactona" RELATED [IUPAC] synonym: "lactonas" RELATED [IUPAC] synonym: "Lakton" RELATED [ChEBI] synonym: "Laktone" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:25022 name: leucomycin namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:25061 name: lipopeptide antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:46895 ! lipopeptide [Term] id: CHEBI:25105 name: macrolide antibiotic namespace: chebi_ontology def: "A macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity." [] subset: 3_STAR synonym: "macrolide antibiotics" RELATED [ChEBI] synonym: "Makrolidantibiotika" RELATED [ChEBI] is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:25106 name: macrolide namespace: chebi_ontology def: "A macrocyclic lactone with a ring of twelve or more members derived from a polyketide." [] subset: 3_STAR synonym: "macrolide" EXACT [ChEBI] synonym: "macrolides" RELATED [ChEBI] synonym: "Makrolid" RELATED [ChEBI] xref: Wikipedia:Macrolide is_a: CHEBI:26188 ! polyketide is_a: CHEBI:63944 ! macrocyclic lactone [Term] id: CHEBI:25154 name: manganese molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "manganese compounds" RELATED [ChEBI] synonym: "manganese molecular entities" RELATED [ChEBI] synonym: "manganese molecular entity" EXACT [ChEBI] is_a: CHEBI:33743 ! manganese group molecular entity relationship: BFO:0000051 CHEBI:18291 ! has part manganese atom [Term] id: CHEBI:25189 name: 1,4-dimercaptobutane-2,3-diol namespace: chebi_ontology def: "A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group." [] subset: 3_STAR synonym: "1,4-dimercapto-2,3-butanediol" RELATED [ChemIDplus] synonym: "1,4-dimercaptobutane-2,3-diol" EXACT [ChemIDplus] is_a: CHEBI:13643 ! glycol is_a: CHEBI:22944 ! butanediols is_a: CHEBI:29256 ! thiol [Term] id: CHEBI:25212 name: metabolite namespace: chebi_ontology alt_id: CHEBI:26619 alt_id: CHEBI:35220 def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." [] subset: 3_STAR synonym: "metabolites" RELATED [ChEBI] synonym: "primary metabolites" RELATED [ChEBI] synonym: "secondary metabolites" RELATED [ChEBI] is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:25213 name: metal cation namespace: chebi_ontology subset: 3_STAR synonym: "a metal cation" RELATED [UniProt] synonym: "metal cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:25248 name: methyl ester namespace: chebi_ontology def: "Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol." [] subset: 3_STAR synonym: "carboxylic acid methyl ester" RELATED [ChEBI] synonym: "carboxylic acid methyl esters" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester relationship: has_functional_parent CHEBI:17790 ! methanol [Term] id: CHEBI:25355 name: mitochondrial respiratory-chain inhibitor namespace: chebi_ontology subset: 3_STAR synonym: "mitochondrial electron transport chain inhibitors" RELATED [ChEBI] synonym: "mitochondrial electron-transport chain inhibitor" RELATED [ChEBI] synonym: "mitochondrial respiratory chain inhibitors" RELATED [ChEBI] is_a: CHEBI:38497 ! respiratory-chain inhibitor [Term] id: CHEBI:25367 name: molecule namespace: chebi_ontology def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." [] subset: 3_STAR synonym: "molecula" RELATED [IUPAC] synonym: "molecule" EXACT [IUPAC] synonym: "molecules" RELATED [IUPAC] synonym: "Molekuel" RELATED [ChEBI] synonym: "neutral molecular compounds" RELATED [IUPAC] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:25384 name: monocarboxylic acid namespace: chebi_ontology def: "An oxoacid containing a single carboxy group." [] subset: 3_STAR synonym: "monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion [Term] id: CHEBI:25388 name: monohydroxybenzoate namespace: chebi_ontology def: "A hydroxybenzoate carrying a single hydroxy substituent at unspecified position." [] subset: 3_STAR synonym: "monohydroxybenzoates" RELATED [ChEBI] is_a: CHEBI:24675 ! hydroxybenzoate relationship: is_conjugate_base_of CHEBI:25389 ! monohydroxybenzoic acid [Term] id: CHEBI:25389 name: monohydroxybenzoic acid namespace: chebi_ontology def: "Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring." [] subset: 3_STAR synonym: "monohydroxybenzoic acids" RELATED [ChEBI] is_a: CHEBI:24676 ! hydroxybenzoic acid relationship: is_conjugate_acid_of CHEBI:25388 ! monohydroxybenzoate [Term] id: CHEBI:25414 name: monoatomic monocation namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic monocations" RELATED [ChEBI] synonym: "monovalent inorganic cations" RELATED [ChEBI] is_a: CHEBI:23906 ! monoatomic cation [Term] id: CHEBI:25435 name: mutagen namespace: chebi_ontology def: "An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution." [] subset: 3_STAR synonym: "mutagene" RELATED [ChEBI] synonym: "mutagenes" RELATED [ChEBI] synonym: "mutagenic agent" RELATED [ChEBI] synonym: "mutageno" RELATED [ChEBI] synonym: "mutagenos" RELATED [ChEBI] synonym: "mutagens" RELATED [ChEBI] xref: Wikipedia:Mutagen is_a: CHEBI:50902 ! genotoxin [Term] id: CHEBI:25442 name: mycotoxin namespace: chebi_ontology def: "Poisonous substance produced by fungi." [] subset: 3_STAR synonym: "fungal toxins" RELATED [ChEBI] synonym: "mycotoxins" RELATED [ChEBI] is_a: CHEBI:27026 ! toxin is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:25471 name: naphthalenemonosulfonate namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25478 ! naphthalenesulfonate [Term] id: CHEBI:25477 name: naphthalenes namespace: chebi_ontology def: "Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound is_a: CHEBI:36785 ! carbobicyclic compound [Term] id: CHEBI:25478 name: naphthalenesulfonate namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:22713 ! arenesulfonate oxoanion [Term] id: CHEBI:25481 name: naphthoquinone namespace: chebi_ontology def: "A polycyclic aromatic ketone metabolite of naphthalene." [] subset: 3_STAR synonym: "naphthoquinones" RELATED [ChEBI] is_a: CHEBI:36141 ! quinone [Term] id: CHEBI:25491 name: nematicide namespace: chebi_ontology def: "A substance used to destroy pests of the phylum Nematoda (roundworms)." [] subset: 3_STAR synonym: "nematicides" RELATED [ChEBI] synonym: "nematocide" RELATED [ChEBI] synonym: "nematocides" RELATED [ChEBI] xref: Wikipedia:Nematicide is_a: CHEBI:25944 ! pesticide [Term] id: CHEBI:25512 name: neurotransmitter namespace: chebi_ontology def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." [] subset: 3_STAR synonym: "neurotransmitters" RELATED [ChEBI] xref: Wikipedia:Neurotransmitter is_a: CHEBI:33280 ! molecular messenger [Term] id: CHEBI:25529 name: pyridinecarboxamide namespace: chebi_ontology def: "A member of the class of pyridines that is a substituted pyridine in which at least one of the substituents is a carboxamide or N-substituted caraboxamide group." [] subset: 3_STAR synonym: "pyridinecarboxamides" RELATED [ChEBI] is_a: CHEBI:26421 ! pyridines is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:25555 name: nitrogen atom namespace: chebi_ontology subset: 3_STAR synonym: "7N" RELATED [IUPAC] synonym: "azote" RELATED [IUPAC] synonym: "N" RELATED [IUPAC] synonym: "nitrogen" RELATED [ChEBI] synonym: "nitrogeno" RELATED [ChEBI] synonym: "Stickstoff" RELATED [ChEBI] xref: WebElements:N is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:25558 name: organonitrogen heterocyclic antibiotic namespace: chebi_ontology subset: 3_STAR synonym: "organonitrogen heterocyclic antibiotics" RELATED [ChEBI] is_a: CHEBI:24531 ! heterocyclic antibiotic is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:25585 name: nonmetal atom namespace: chebi_ontology subset: 3_STAR synonym: "Nichtmetall" RELATED [ChEBI] synonym: "Nichtmetalle" RELATED [ChEBI] synonym: "no metal" RELATED [ChEBI] synonym: "no metales" RELATED [ChEBI] synonym: "non-metal" RELATED [ChEBI] synonym: "non-metaux" RELATED [ChEBI] synonym: "nonmetal" RELATED [ChEBI] synonym: "nonmetals" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:25605 name: nucleoside antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:25608 name: nucleoside phosphate namespace: chebi_ontology def: "A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates." [] subset: 3_STAR synonym: "NMP" RELATED [KEGG_COMPOUND] synonym: "nucleoside phosphates" RELATED [ChEBI] xref: KEGG:C01329 is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester is_a: CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_functional_parent CHEBI:33838 ! nucleoside [Term] id: CHEBI:25675 name: oligomycin namespace: chebi_ontology def: "Any of the 26-membered ring macrolides produced by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases." [] subset: 3_STAR synonym: "oligomycins" RELATED [ChEBI] xref: Wikipedia:Oligomycin is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:72600 ! spiroketal relationship: RO:0000087 CHEBI:20854 ! has role ATP synthase inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:25676 name: oligopeptide namespace: chebi_ontology alt_id: CHEBI:7755 def: "A peptide containing a relatively small number of amino acids." [] subset: 3_STAR synonym: "Oligopeptid" RELATED [ChEBI] synonym: "oligopeptido" RELATED [ChEBI] xref: Wikipedia:Oligopeptide is_a: CHEBI:16670 ! peptide [Term] id: CHEBI:25693 name: organic heteromonocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic heteromonocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33670 ! heteromonocyclic compound [Term] id: CHEBI:25696 name: organic anion namespace: chebi_ontology def: "Any organic ion with a net negative charge." [] subset: 3_STAR synonym: "organic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:25699 ! organic ion [Term] id: CHEBI:25697 name: organic cation namespace: chebi_ontology def: "Any organic ion with a net positive charge." [] subset: 3_STAR synonym: "organic cations" RELATED [ChEBI] is_a: CHEBI:25699 ! organic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:25698 name: ether namespace: chebi_ontology def: "An organooxygen compound with formula ROR, where R is not hydrogen." [] subset: 3_STAR synonym: "ethers" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:25699 name: organic ion namespace: chebi_ontology subset: 3_STAR synonym: "organic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:25703 name: organic phosphate namespace: chebi_ontology subset: 3_STAR synonym: "organic phosphate" EXACT [ChEBI] synonym: "organic phosphate ester" RELATED [ChEBI] synonym: "organic phosphate esters" RELATED [ChEBI] synonym: "organic phosphates" RELATED [ChEBI] synonym: "organophosphate ester" RELATED [ChEBI] synonym: "organophosphate esters" RELATED [ChEBI] xref: Wikipedia:Organophosphate is_a: CHEBI:25710 ! organophosphorus compound is_a: CHEBI:26020 ! phosphate [Term] id: CHEBI:25704 name: organic sulfate namespace: chebi_ontology def: "Compounds of the general formula SO3HOR where R is an organyl group" [] subset: 3_STAR synonym: "organic sulfates" RELATED [ChEBI] is_a: CHEBI:26820 ! sulfates relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion [Term] id: CHEBI:2571 name: aliphatic alcohol namespace: chebi_ontology def: "An alcohol derived from an aliphatic compound." [] subset: 3_STAR synonym: "Aliphatic alcohol" EXACT [KEGG_COMPOUND] synonym: "aliphatic alcohols" RELATED [ChEBI] synonym: "an aliphatic alcohol" RELATED [UniProt] xref: KEGG:C02525 is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:25710 name: organophosphorus compound namespace: chebi_ontology def: "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." [] subset: 3_STAR synonym: "organophosphorus compound" EXACT [ChEBI] synonym: "organophosphorus compounds" RELATED [ChEBI] xref: Wikipedia:Organophosphorus_compound is_a: CHEBI:26082 ! phosphorus molecular entity is_a: CHEBI:33285 ! heteroorganic entity [Term] id: CHEBI:25728 name: osmolyte namespace: chebi_ontology def: "A solute used by a cell under water stress to maintain cell volume." [] subset: 3_STAR synonym: "osmolytes" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:25741 name: oxide namespace: chebi_ontology def: "An oxide is a chemical compound of oxygen with other chemical elements." [] subset: 3_STAR synonym: "oxide" EXACT [ChEBI] synonym: "oxides" RELATED [ChEBI] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:25750 name: oxime namespace: chebi_ontology def: "Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes." [] subset: 3_STAR synonym: "oxime" EXACT [IUPAC] synonym: "oximes" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity is_a: CHEBI:51143 ! nitrogen molecular entity relationship: is_conjugate_acid_of CHEBI:142513 ! oxime anion [Term] id: CHEBI:25754 name: oxo carboxylic acid namespace: chebi_ontology def: "Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule." [] subset: 3_STAR synonym: "oxo acids" RELATED [IUPAC] synonym: "oxo carboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35903 ! oxo carboxylic acid anion [Term] id: CHEBI:2580 name: unsaturated fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion containing at least one C-C unsaturated bond; formed by deprotonation of the carboxylic acid moiety." [] subset: 3_STAR is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:27208 ! unsaturated fatty acid [Term] id: CHEBI:25805 name: oxygen atom namespace: chebi_ontology subset: 3_STAR synonym: "8O" RELATED [IUPAC] synonym: "O" RELATED [IUPAC] synonym: "oxigeno" RELATED [ChEBI] synonym: "oxygen" RELATED [ChEBI] synonym: "oxygene" RELATED [ChEBI] synonym: "Sauerstoff" RELATED [ChEBI] xref: KEGG:C00007 xref: WebElements:O is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:25806 name: oxygen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "oxygen molecular entities" RELATED [ChEBI] synonym: "oxygen molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: BFO:0000051 CHEBI:25805 ! has part oxygen atom [Term] id: CHEBI:25807 name: organooxygen heterocyclic antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24531 ! heterocyclic antibiotic [Term] id: CHEBI:25830 name: p-quinones namespace: chebi_ontology def: "A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring." [] subset: 3_STAR synonym: "p-quinone" RELATED [ChEBI] synonym: "para-quinones" RELATED [ChEBI] is_a: CHEBI:36141 ! quinone [Term] id: CHEBI:25865 name: penicillanic acids namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:35992 ! penams [Term] id: CHEBI:25900 name: aldopentose phosphate namespace: chebi_ontology subset: 3_STAR synonym: "aldopentose phosphate" EXACT [ChEBI] synonym: "aldopentose phosphates" RELATED [ChEBI] is_a: CHEBI:35131 ! aldose phosphate is_a: CHEBI:84055 ! pentose phosphate [Term] id: CHEBI:25901 name: pentose namespace: chebi_ontology def: "A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose)." [] subset: 3_STAR synonym: "pentose" EXACT [ChEBI] synonym: "pentoses" RELATED [ChEBI] is_a: CHEBI:35381 ! monosaccharide [Term] id: CHEBI:25903 name: peptide antibiotic namespace: chebi_ontology def: "A chemically diverse class of peptides that exhibit antimicrobial properties." [] subset: 3_STAR synonym: "peptide antibiotics" RELATED [ChEBI] xref: MetaCyc:Peptide-Antibiotics is_a: CHEBI:16670 ! peptide relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:25940 name: peroxides namespace: chebi_ontology def: "Compounds of structure ROOR'." [] subset: 3_STAR synonym: "a peroxide" RELATED [UniProt] is_a: CHEBI:25741 ! oxide relationship: BFO:0000051 CHEBI:29369 ! has part peroxy group relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent [Term] id: CHEBI:25944 name: pesticide namespace: chebi_ontology def: "Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests." [] subset: 3_STAR synonym: "pesticides" RELATED [ChEBI] synonym: "Pestizid" RELATED [ChEBI] synonym: "Pestizide" RELATED [ChEBI] xref: Wikipedia:Pesticide is_a: CHEBI:33232 ! application [Term] id: CHEBI:26004 name: phenylpropanoid namespace: chebi_ontology def: "Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin." [] subset: 3_STAR synonym: "phenylpropanoids" RELATED [ChEBI] xref: Wikipedia:Phenylpropanoid is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:26020 name: phosphate namespace: chebi_ontology def: "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." [] subset: 3_STAR synonym: "phosphates" RELATED [ChEBI] is_a: CHEBI:26079 ! phosphoric acid derivative [Term] id: CHEBI:26045 name: phosphite ion namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33461 ! phosphorus oxoanion [Term] id: CHEBI:26069 name: phosphonic acids namespace: chebi_ontology def: "HP(=O)(OH)2 (phosphonic acid) and its P-substituted derivatives." [] subset: 3_STAR is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:26078 name: phosphoric acid namespace: chebi_ontology def: "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." [] subset: 3_STAR synonym: "[PO(OH)3]" RELATED [IUPAC] synonym: "acide phosphorique" RELATED [ChEBI] synonym: "acidum phosphoricum" RELATED [ChEBI] synonym: "H3PO4" RELATED [IUPAC] synonym: "Orthophosphoric acid" RELATED [KEGG_COMPOUND] synonym: "orthophosphoric acid" RELATED [NIST_Chemistry_WebBook] synonym: "Phosphate" RELATED [KEGG_COMPOUND] synonym: "Phosphoric acid" EXACT [KEGG_COMPOUND] synonym: "phosphoric acid" EXACT [IUPAC] synonym: "Phosphorsaeure" RELATED [ChEBI] synonym: "Phosphorsaeureloesungen" RELATED [ChEBI] xref: HMDB:HMDB0002142 xref: KEGG:C00009 xref: KEGG:D05467 xref: KNApSAcK:C00007408 xref: Wikipedia:Phosphoric_Acid is_a: CHEBI:59698 ! phosphoric acids relationship: is_conjugate_acid_of CHEBI:39745 ! dihydrogenphosphate relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound relationship: RO:0000087 CHEBI:33287 ! has role fertilizer relationship: RO:0000087 CHEBI:46787 ! has role solvent relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite [Term] id: CHEBI:26079 name: phosphoric acid derivative namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:36359 ! phosphorus oxoacid derivative relationship: has_functional_parent CHEBI:26078 ! phosphoric acid [Term] id: CHEBI:26082 name: phosphorus molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "phosphorus molecular entities" RELATED [ChEBI] is_a: CHEBI:33302 ! pnictogen molecular entity relationship: BFO:0000051 CHEBI:28659 ! has part phosphorus atom [Term] id: CHEBI:26094 name: benzenedicarboxylic acid namespace: chebi_ontology def: "A member of the class of benzoic acids in that consists of benzene substituted by two carboxy groups (A closed class)." [] subset: 3_STAR is_a: CHEBI:22723 ! benzoic acids is_a: CHEBI:35692 ! dicarboxylic acid [Term] id: CHEBI:26115 name: phytoalexin namespace: chebi_ontology def: "A toxin made by a plant that acts against an organism attacking it." [] subset: 3_STAR synonym: "phytoalexins" RELATED [ChEBI] is_a: CHEBI:38231 ! phytotoxin [Term] id: CHEBI:26130 name: biological pigment namespace: chebi_ontology def: "An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light." [] subset: 3_STAR synonym: "pigments" RELATED [ChEBI] is_a: CHEBI:52208 ! biophysical role [Term] id: CHEBI:26144 name: piperazines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26151 name: piperidines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26155 name: plant growth regulator namespace: chebi_ontology def: "A chemical, natural or artificial, that can affect the rate of growth of a plant." [] subset: 3_STAR synonym: "plant growth regulators" RELATED [ChEBI] is_a: CHEBI:39317 ! growth regulator [Term] id: CHEBI:26167 name: polar amino acid namespace: chebi_ontology alt_id: CHEBI:8283 def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." [] subset: 3_STAR synonym: "polar amino acid" EXACT [ChEBI] synonym: "polar amino acids" RELATED [ChEBI] synonym: "polar amino-acid" RELATED [ChEBI] synonym: "polar amino-acids" RELATED [ChEBI] xref: MetaCyc:Polar-amino-acids is_a: CHEBI:33709 ! amino acid relationship: is_tautomer_of CHEBI:62031 ! polar amino acid zwitterion [Term] id: CHEBI:26177 name: polyene antibiotic namespace: chebi_ontology def: "A family of antibiotics containing a conjugated polyene moiety, usuallly isolated from some species of Streptomyces." [] subset: 3_STAR synonym: "polyene antibiotics" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:26188 name: polyketide namespace: chebi_ontology def: "Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides." [] subset: 3_STAR synonym: "polyketide" EXACT [ChEBI] synonym: "polyketides" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:26191 name: polyol namespace: chebi_ontology def: "A compound that contains two or more hydroxy groups." [] subset: 3_STAR synonym: "polyols" RELATED [ChEBI] is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:26195 name: polyphenol namespace: chebi_ontology def: "Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group." [] subset: 3_STAR synonym: "polyphenols" RELATED [ChEBI] xref: Wikipedia:Polyphenol is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:26199 name: polyprenol namespace: chebi_ontology alt_id: CHEBI:8317 def: "Any member of the class of prenols possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of more than one isoprene units." [] subset: 3_STAR synonym: "polyprenols" RELATED [ChEBI] xref: KEGG:C06081 is_a: CHEBI:26244 ! prenols [Term] id: CHEBI:26208 name: polyunsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome." [] subset: 3_STAR synonym: "polyunsaturated fatty acids" RELATED [ChEBI] synonym: "PUFA" RELATED [ChEBI] synonym: "PUFAs" RELATED [ChEBI] is_a: CHEBI:27208 ! unsaturated fatty acid relationship: is_conjugate_acid_of CHEBI:76567 ! polyunsaturated fatty acid anion [Term] id: CHEBI:26216 name: potassium atom namespace: chebi_ontology subset: 3_STAR synonym: "19K" RELATED [IUPAC] synonym: "K" RELATED [IUPAC] synonym: "Kalium" RELATED [ChemIDplus] synonym: "kalium" RELATED [IUPAC] synonym: "potasio" RELATED [ChEBI] synonym: "potassium" RELATED [ChEBI] xref: DrugBank:DB01345 xref: KEGG:C00238 xref: WebElements:K is_a: CHEBI:22314 ! alkali metal atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite [Term] id: CHEBI:26217 name: potassium molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "potassium molecular entities" RELATED [ChEBI] synonym: "potassium molecular entity" EXACT [ChEBI] is_a: CHEBI:33296 ! alkali metal molecular entity relationship: BFO:0000051 CHEBI:26216 ! has part potassium atom [Term] id: CHEBI:26218 name: potassium salt namespace: chebi_ontology def: "Any alkali metal salt having potassium(1+) as the cation." [] subset: 3_STAR synonym: "Kaliumsalz" RELATED [ChEBI] synonym: "Kaliumsalze" RELATED [ChEBI] synonym: "potassium salts" RELATED [ChEBI] is_a: CHEBI:26217 ! potassium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: BFO:0000051 CHEBI:29103 ! has part potassium(1+) [Term] id: CHEBI:26244 name: prenols namespace: chebi_ontology def: "Any alcohol possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of one or more isoprene units (biogenetic precursors of the isoprenoids)." [] subset: 3_STAR is_a: CHEBI:24913 ! isoprenoid is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:26271 name: proline namespace: chebi_ontology def: "An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2." [] subset: 3_STAR synonym: "DL-Proline" RELATED [KEGG_COMPOUND] synonym: "Hpro" RELATED [IUPAC] synonym: "Prolin" RELATED [ChEBI] synonym: "prolina" RELATED [ChEBI] synonym: "proline" EXACT [ChEBI] synonym: "pyrrolidine-2-carboxylic acid" RELATED [IUPAC] xref: KEGG:C16435 xref: Wikipedia:Proline is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:38260 ! pyrrolidines relationship: is_conjugate_acid_of CHEBI:32871 ! prolinate relationship: is_conjugate_base_of CHEBI:32872 ! prolinium relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite [Term] id: CHEBI:26273 name: proline derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues." [] subset: 3_STAR synonym: "proline derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino-acid derivative relationship: has_functional_parent CHEBI:26271 ! proline [Term] id: CHEBI:2634 name: amidine namespace: chebi_ontology def: "Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine." [] subset: 3_STAR synonym: "amidine" EXACT [IUPAC] synonym: "Amidines" RELATED [KEGG_COMPOUND] synonym: "amidines" RELATED [ChEBI] is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:2637 name: amikacin namespace: chebi_ontology def: "An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group." [] subset: 3_STAR synonym: "1-N-(L(-)-gamma-amino-alpha-hydroxybutyryl)kanamycin A" RELATED [ChemIDplus] synonym: "Amikacin" EXACT [KEGG_COMPOUND] synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine" RELATED [ChemIDplus] xref: DrugBank:DB00479 xref: HMDB:HMDB0014622 xref: KEGG:C06820 xref: KEGG:D02543 xref: LINCS:LSM-5935 xref: MetaCyc:CPD-14197 xref: Patent:DE2234315 xref: Patent:US3781268 xref: Wikipedia:Amikacin is_a: CHEBI:22390 ! alpha-D-glucoside is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:47779 ! aminoglycoside relationship: has_functional_parent CHEBI:17630 ! kanamycin A relationship: is_conjugate_base_of CHEBI:84739 ! amikacin(4+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50909 ! has role nephrotoxic agent [Term] id: CHEBI:26395 name: purine nucleotide namespace: chebi_ontology def: "Any nucleotide that has a purine nucleobase." [] subset: 3_STAR synonym: "purine nucleotides" RELATED [ChEBI] is_a: CHEBI:26401 ! purines is_a: CHEBI:36976 ! nucleotide [Term] id: CHEBI:26400 name: purine ribonucleotide namespace: chebi_ontology def: "Any ribonucleotide that has a purine nucleobase." [] subset: 3_STAR synonym: "purine ribonucleotides" RELATED [ChEBI] is_a: CHEBI:26395 ! purine nucleotide is_a: CHEBI:26561 ! ribonucleotide [Term] id: CHEBI:26401 name: purines namespace: chebi_ontology alt_id: CHEBI:13678 def: "A class of imidazopyrimidines that consists of purine and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:35875 ! imidazopyrimidine [Term] id: CHEBI:26416 name: pyridine alkaloid namespace: chebi_ontology subset: 3_STAR synonym: "pyridine alkaloids" RELATED [ChEBI] is_a: CHEBI:22315 ! alkaloid is_a: CHEBI:26421 ! pyridines [Term] id: CHEBI:26420 name: pyridinemonocarboxylic acid namespace: chebi_ontology def: "A monocarboxylic acid in which the carboxy group is attached to a pyridine (or substituted pyridine) ring." [] subset: 3_STAR synonym: "pyridinemonocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:26421 ! pyridines is_a: CHEBI:33859 ! aromatic carboxylic acid relationship: is_conjugate_acid_of CHEBI:38181 ! pyridinemonocarboxylate [Term] id: CHEBI:26421 name: pyridines namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26432 name: pyrimidine nucleobase namespace: chebi_ontology def: "A nucleobase whose skeleton is derived from pyrimidine." [] subset: 3_STAR synonym: "a pyrimidine nucleobase" RELATED [UniProt] synonym: "pyrimidine bases" RELATED [ChEBI] synonym: "pyrimidine nucleobase" EXACT [ChEBI] synonym: "pyrimidine nucleobases" RELATED [ChEBI] is_a: CHEBI:18282 ! nucleobase is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:26440 name: pyrimidine nucleoside namespace: chebi_ontology subset: 3_STAR synonym: "N-D-Ribosylpyrimidine" RELATED [KEGG_COMPOUND] synonym: "pyrimidine nucleosides" RELATED [ChEBI] xref: KEGG:C03169 is_a: CHEBI:33838 ! nucleoside is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:26455 name: pyrroles namespace: chebi_ontology def: "An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton." [] subset: 3_STAR is_a: CHEBI:68452 ! azole [Term] id: CHEBI:26469 name: quaternary nitrogen compound namespace: chebi_ontology def: "A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen." [] subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound relationship: BFO:0000051 CHEBI:35267 ! has part quaternary ammonium ion [Term] id: CHEBI:26509 name: quinoline alkaloid namespace: chebi_ontology subset: 3_STAR synonym: "quinoline alkaloids" RELATED [ChEBI] is_a: CHEBI:22315 ! alkaloid [Term] id: CHEBI:26512 name: quinolinemonocarboxylic acid namespace: chebi_ontology def: "Any aromatic carboxylic acid that contains a quinoline moiety that is substituted by one carboxy substituent." [] subset: 3_STAR synonym: "quinolinemonocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:26513 ! quinolines is_a: CHEBI:33859 ! aromatic carboxylic acid relationship: is_conjugate_acid_of CHEBI:38773 ! quinolinemonocarboxylate [Term] id: CHEBI:26513 name: quinolines namespace: chebi_ontology def: "A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring." [] subset: 3_STAR is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:26523 name: reactive oxygen species namespace: chebi_ontology def: "Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [] subset: 3_STAR synonym: "ROS" RELATED [ChEBI] xref: Wikipedia:Reactive_oxygen_species is_a: CHEBI:25806 ! oxygen molecular entity [Term] id: CHEBI:26561 name: ribonucleotide namespace: chebi_ontology subset: 3_STAR synonym: "ribonucleotides" RELATED [ChEBI] is_a: CHEBI:26562 ! ribose phosphate is_a: CHEBI:36976 ! nucleotide [Term] id: CHEBI:26562 name: ribose phosphate namespace: chebi_ontology subset: 3_STAR synonym: "ribose phosphate" EXACT [ChEBI] synonym: "ribose phosphates" RELATED [ChEBI] is_a: CHEBI:25900 ! aldopentose phosphate [Term] id: CHEBI:26580 name: rifamycins namespace: chebi_ontology subset: 3_STAR synonym: "rifamycin" RELATED [ChEBI] xref: Wikipedia:Rifamycin is_a: CHEBI:22565 ! ansamycin is_a: CHEBI:39270 ! naphthofuran [Term] id: CHEBI:26588 name: 1,3,5-triazines namespace: chebi_ontology def: "Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure." [] subset: 3_STAR synonym: "s-triazines" RELATED [ChEBI] is_a: CHEBI:38102 ! triazines [Term] id: CHEBI:26607 name: saturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." [] subset: 3_STAR synonym: "saturated fatty acid" EXACT [ChEBI] synonym: "saturated fatty acids" RELATED [ChEBI] synonym: "SFA" RELATED [ChEBI] synonym: "SFAs" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid [Term] id: CHEBI:26649 name: serine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of serine by a heteroatom. The definition normally excludes peptides containing serine residues." [] subset: 3_STAR synonym: "serine derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino-acid derivative relationship: has_functional_parent CHEBI:17822 ! serine [Term] id: CHEBI:26658 name: sesquiterpenoid namespace: chebi_ontology def: "Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." [] subset: 3_STAR synonym: "sesquiterpenoides" RELATED [ChEBI] synonym: "sesquiterpenoids" RELATED [ChEBI] is_a: CHEBI:26873 ! terpenoid relationship: has_parent_hydride CHEBI:35189 ! sesquiterpene [Term] id: CHEBI:26666 name: short-chain fatty acid namespace: chebi_ontology def: "An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." [] subset: 3_STAR synonym: "SCFA" RELATED [ChEBI] synonym: "SCFAs" RELATED [ChEBI] synonym: "short-chain fatty acids" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:58951 ! short-chain fatty acid anion [Term] id: CHEBI:26708 name: sodium atom namespace: chebi_ontology subset: 3_STAR synonym: "11Na" RELATED [IUPAC] synonym: "Na" RELATED [IUPAC] synonym: "Natrium" RELATED [ChemIDplus] synonym: "natrium" RELATED [IUPAC] synonym: "sodio" RELATED [ChemIDplus] synonym: "sodium" RELATED [ChEBI] xref: KEGG:C01330 xref: WebElements:Na is_a: CHEBI:22314 ! alkali metal atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite [Term] id: CHEBI:26710 name: sodium chloride namespace: chebi_ontology def: "An inorganic chloride salt having sodium(1+) as the counterion." [] subset: 3_STAR synonym: "chlorure de sodium" RELATED [ChEBI] synonym: "cloruro sodico" RELATED [ChEBI] synonym: "common salt" RELATED [ChemIDplus] synonym: "halite" RELATED [NIST_Chemistry_WebBook] synonym: "Kochsalz" RELATED [ChEBI] synonym: "NaCl" RELATED [IUPAC] synonym: "natrii chloridum" RELATED [ChEBI] synonym: "Natriumchlorid" RELATED [NIST_Chemistry_WebBook] synonym: "rock salt" RELATED [ChemIDplus] synonym: "salt" RELATED [ChemIDplus] synonym: "sodium chloride" EXACT [ChEBI] synonym: "table salt" RELATED [ChemIDplus] xref: KEGG:C13563 xref: KEGG:D02056 xref: MetaCyc:NACL xref: PPDB:595 xref: Wikipedia:Sodium_Chloride is_a: CHEBI:36093 ! inorganic chloride is_a: CHEBI:38702 ! inorganic sodium salt relationship: RO:0000087 CHEBI:149552 ! has role emetic relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound relationship: RO:0000087 CHEBI:79314 ! has role flame retardant [Term] id: CHEBI:26712 name: sodium molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sodium compounds" RELATED [ChEBI] synonym: "sodium molecular entities" RELATED [ChEBI] is_a: CHEBI:33296 ! alkali metal molecular entity relationship: BFO:0000051 CHEBI:26708 ! has part sodium atom [Term] id: CHEBI:26714 name: sodium salt namespace: chebi_ontology def: "Any alkali metal salt having sodium(1+) as the cation." [] subset: 3_STAR synonym: "Natriumsalz" RELATED [ChEBI] synonym: "Natriumsalze" RELATED [ChEBI] synonym: "sodium salts" RELATED [ChEBI] is_a: CHEBI:26712 ! sodium molecular entity is_a: CHEBI:35479 ! alkali metal salt relationship: BFO:0000051 CHEBI:29101 ! has part sodium(1+) [Term] id: CHEBI:26739 name: sphingolipid namespace: chebi_ontology def: "Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone." [] subset: 3_STAR synonym: "sphingolipids" RELATED [ChEBI] is_a: CHEBI:18059 ! lipid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:2676 name: amoxicillin namespace: chebi_ontology alt_id: CHEBI:133770 def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid" RELATED [ChemIDplus] synonym: "alpha-amino-p-hydroxybenzylpenicillin" RELATED [ChemIDplus] synonym: "Amoxicillin" EXACT [KEGG_COMPOUND] synonym: "Amoxicillin anhydrous" RELATED [KEGG_COMPOUND] synonym: "amoxycilin" RELATED [ChEBI] synonym: "amoxycillin" RELATED [ChemIDplus] synonym: "AX" RELATED [ChEBI] synonym: "p-hydroxyampicillin" RELATED [ChemIDplus] xref: DrugBank:DB01060 xref: HMDB:HMDB0015193 xref: KEGG:C06827 xref: KEGG:D07452 xref: LINCS:LSM-5654 xref: Patent:DE1942693 xref: Patent:GB1241844 xref: Patent:GB978178 xref: Patent:US3192198 xref: VSDB:1741 xref: Wikipedia:Amoxicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51256 ! amoxicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:26761 name: steroid antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:35341 ! steroid is_a: CHEBI:49319 ! carbocyclic antibiotic [Term] id: CHEBI:26775 name: stilbene namespace: chebi_ontology subset: 3_STAR synonym: "1,1'-(1,2-ethenediyl)bis[benzene]" RELATED [NIST_Chemistry_WebBook] synonym: "1,1'-(1,2-ethenediyl)bisbenzene" RELATED [ChemIDplus] synonym: "1,1'-(1,2-ethenediyl)dibenzene" RELATED [ChemIDplus] synonym: "1,1'-ethene-1,2-diyldibenzene" RELATED [ChEBI] synonym: "1,2-diphenylethylene" RELATED [NIST_Chemistry_WebBook] synonym: "alpha,beta-diphenylethylene" RELATED [NIST_Chemistry_WebBook] synonym: "stilbene" EXACT [ChemIDplus] xref: Wikipedia:Stilbene is_a: CHEBI:22712 ! benzenes is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:26776 name: stilbenoid namespace: chebi_ontology def: "Any olefinic compound characterised by a 1,2-diphenylethylene backbone." [] subset: 3_STAR synonym: "stilbenes" RELATED [ChEBI] synonym: "stilbenoids" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:26788 name: streptomycins namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic [Term] id: CHEBI:26816 name: carbohydrate phosphate namespace: chebi_ontology subset: 3_STAR synonym: "carbohydrate phosphates" RELATED [ChEBI] is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:26819 name: sulfuric ester namespace: chebi_ontology def: "An ester of an alcohol and sulfuric acid." [] subset: 3_STAR synonym: "sulfate ester" RELATED [ChEBI] synonym: "sulfuric acid ester" RELATED [ChEBI] synonym: "sulfuric acid esters" RELATED [ChEBI] is_a: CHEBI:35701 ! ester is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:2682 name: amphotericin B namespace: chebi_ontology alt_id: CHEBI:106303 alt_id: CHEBI:566395 def: "A macrolide antibiotic used to treat potentially life-threatening fungal infections." [] subset: 3_STAR synonym: "AMPH-B" RELATED [DrugBank] synonym: "Amphotericine B" RELATED [DrugBank] synonym: "Liposomal Amphotericin B" RELATED [DrugBank] xref: DrugBank:DB00681 xref: KEGG:C06573 xref: KEGG:D00203 xref: Patent:US2908611 xref: Wikipedia:Amphotericin_B is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26177 ! polyene antibiotic is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: RO:0000087 CHEBI:171664 ! has role antiamoebic agent relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:26820 name: sulfates namespace: chebi_ontology def: "Salts and esters of sulfuric acid" [] subset: 3_STAR synonym: "sulfates" EXACT [ChEBI] synonym: "sulfuric acid derivative" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:37826 ! sulfuric acid derivative [Term] id: CHEBI:26822 name: sulfide namespace: chebi_ontology def: "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." [] subset: 3_STAR synonym: "sulphides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:26830 name: sulfonium compound namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:26833 name: sulfur atom namespace: chebi_ontology subset: 3_STAR synonym: "16S" RELATED [IUPAC] synonym: "azufre" RELATED [ChEBI] synonym: "Elemental sulfur" RELATED [KEGG_COMPOUND] synonym: "S" RELATED [IUPAC, KEGG_COMPOUND] synonym: "Schwefel" RELATED [ChEBI] synonym: "soufre" RELATED [ChEBI] synonym: "sulfur" RELATED [ChEBI, UniProt] synonym: "sulphur" RELATED [ChEBI] synonym: "theion" RELATED [IUPAC] xref: KEGG:C00087 xref: KEGG:D06527 xref: PPDB:605 xref: WebElements:S is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33303 ! chalcogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:26835 name: sulfur molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "sulfur molecular entities" RELATED [ChEBI] synonym: "sulfur molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: BFO:0000051 CHEBI:26833 ! has part sulfur atom [Term] id: CHEBI:26836 name: sulfuric acid namespace: chebi_ontology def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." [] subset: 3_STAR synonym: "[S(OH)2O2]" RELATED [MolBase] synonym: "[SO2(OH)2]" RELATED [IUPAC] synonym: "Acide sulfurique" RELATED [ChemIDplus] synonym: "Acido sulfurico" RELATED [ChemIDplus] synonym: "Acidum sulfuricum" RELATED [ChemIDplus] synonym: "H2SO4" RELATED [IUPAC] synonym: "Schwefelsaeureloesungen" RELATED [ChemIDplus] synonym: "Sulfuric acid" EXACT [KEGG_COMPOUND] synonym: "sulfuric acid" EXACT [ChEBI] synonym: "sulphuric acid" RELATED [MolBase] xref: KEGG:C00059 xref: KEGG:D05963 xref: KNApSAcK:C00007530 xref: MolBase:4 xref: PPDB:606 xref: Wikipedia:Sulfuric_acid is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate relationship: RO:0000087 CHEBI:35223 ! has role catalyst [Term] id: CHEBI:26873 name: terpenoid namespace: chebi_ontology def: "Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group." [] subset: 3_STAR synonym: "Terpenoid" EXACT [ChEBI] synonym: "terpenoide" RELATED [IUPAC] synonym: "terpenoides" RELATED [IUPAC] xref: Wikipedia:Terpenoid is_a: CHEBI:24913 ! isoprenoid relationship: has_parent_hydride CHEBI:35186 ! terpene [Term] id: CHEBI:26878 name: tertiary alcohol namespace: chebi_ontology def: "A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it." [] subset: 3_STAR synonym: "tertiary alcohol" EXACT [ChEBI] synonym: "tertiary alcohols" RELATED [ChEBI] is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:26888 name: tetrachlorobenzene namespace: chebi_ontology def: "Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions." [] subset: 3_STAR synonym: "Tetrachlorbenzol" RELATED [ChEBI] is_a: CHEBI:23132 ! chlorobenzenes [Term] id: CHEBI:26895 name: tetracyclines namespace: chebi_ontology def: "A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups." [] subset: 3_STAR is_a: CHEBI:26188 ! polyketide relationship: has_parent_hydride CHEBI:32600 ! tetracene relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:26912 name: oxolanes namespace: chebi_ontology def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:26959 name: thiocarboxylic ester namespace: chebi_ontology def: "An ester in which one or both oxygens of an ester group have been replaced by divalent sulfur." [] subset: 3_STAR synonym: "thiocarboxylic esters" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:35701 ! ester [Term] id: CHEBI:26979 name: organic heterotricyclic compound namespace: chebi_ontology def: "An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms." [] subset: 3_STAR synonym: "heterotricyclic compounds" RELATED [ChEBI] synonym: "organic heterotricyclic compounds" RELATED [ChEBI] is_a: CHEBI:36688 ! heterotricyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound is_a: CHEBI:51959 ! organic tricyclic compound [Term] id: CHEBI:27026 name: toxin namespace: chebi_ontology def: "Poisonous substance produced by a biological organism such as a microbe, animal or plant." [] subset: 3_STAR synonym: "toxins" RELATED [ChEBI] xref: Wikipedia:Toxin is_a: CHEBI:25212 ! metabolite is_a: CHEBI:64909 ! poison [Term] id: CHEBI:27027 name: micronutrient namespace: chebi_ontology def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." [] subset: 3_STAR synonym: "micronutrients" RELATED [ChEBI] synonym: "trace elements" RELATED [ChEBI] xref: Wikipedia:Micronutrient is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:27081 name: transition element atom namespace: chebi_ontology def: "An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell." [] subset: 3_STAR synonym: "metal de transicion" RELATED [ChEBI] synonym: "metal de transition" RELATED [ChEBI] synonym: "metales de transicion" RELATED [ChEBI] synonym: "metaux de transition" RELATED [ChEBI] synonym: "transition element" RELATED [ChEBI] synonym: "transition elements" RELATED [ChEBI] synonym: "transition metal" RELATED [ChEBI] synonym: "transition metals" RELATED [ChEBI] synonym: "Uebergangselement" RELATED [ChEBI] synonym: "Uebergangsmetalle" RELATED [ChEBI] is_a: CHEBI:33521 ! metal atom [Term] id: CHEBI:27096 name: trichlorobenzene namespace: chebi_ontology def: "Any member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions." [] subset: 3_STAR synonym: "Trichlorbenzol" RELATED [ChEBI] xref: Wikipedia:Trichlorobenzene is_a: CHEBI:23132 ! chlorobenzenes [Term] id: CHEBI:27136 name: triol namespace: chebi_ontology def: "A chemical compound containing three hydroxy groups." [] subset: 3_STAR synonym: "triols" RELATED [ChEBI] is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:27171 name: organic heterobicyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterobicyclic compounds" RELATED [ChEBI] synonym: "organic heterobicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33672 ! heterobicyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:27207 name: univalent carboacyl group namespace: chebi_ontology def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "univalent acyl group" RELATED [ChEBI] synonym: "univalent carboacyl groups" RELATED [ChEBI] synonym: "univalent carboxylic acyl groups" RELATED [ChEBI] is_a: CHEBI:37838 ! carboacyl group [Term] id: CHEBI:27208 name: unsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing at least one C=C or C#C bond." [] subset: 3_STAR synonym: "alkene acid" RELATED [ChEBI] synonym: "olefinic acid" RELATED [ChEBI] synonym: "unsaturated fatty acids" RELATED [ChEBI, LIPID_MAPS] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:2580 ! unsaturated fatty acid anion [Term] id: CHEBI:27242 name: uridines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:39446 ! pyrimidine ribonucleosides relationship: has_functional_parent CHEBI:17568 ! uracil [Term] id: CHEBI:27283 name: very long-chain fatty acid namespace: chebi_ontology def: "A fatty acid which has a chain length greater than C22. Very long-chain fatty acids which have a chain length greater than C27 are also known as ultra-long-chain fatty acids." [] subset: 3_STAR synonym: "higher fatty acid" RELATED [ChEBI] synonym: "very long-chain fatty acids" RELATED [ChEBI] synonym: "VLCFA" RELATED [ChEBI] synonym: "VLCFAs" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:58950 ! very long-chain fatty acid anion [Term] id: CHEBI:27311 name: volatile oil component namespace: chebi_ontology def: "Any plant metabolite that is found naturally as a component of a volatile oil." [] subset: 3_STAR synonym: "essential oil component" RELATED [ChEBI] synonym: "essential oil components" RELATED [ChEBI] synonym: "ethereal oil component" RELATED [ChEBI] synonym: "ethereal oil components" RELATED [ChEBI] synonym: "volatile oil components" RELATED [ChEBI] xref: Wikipedia:Essential_oil is_a: CHEBI:76924 ! plant metabolite [Term] id: CHEBI:27314 name: water-soluble vitamin (role) namespace: chebi_ontology def: "Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine." [] subset: 3_STAR synonym: "wasserloesliche Vitamine" RELATED [ChEBI] synonym: "water-soluble vitamin" RELATED [ChEBI] synonym: "water-soluble vitamins" RELATED [ChEBI] is_a: CHEBI:33229 ! vitamin (role) [Term] id: CHEBI:27363 name: zinc atom namespace: chebi_ontology subset: 3_STAR synonym: "30Zn" RELATED [IUPAC] synonym: "cinc" RELATED [ChEBI] synonym: "zinc" RELATED [ChEBI] synonym: "zincum" RELATED [ChEBI] synonym: "Zink" RELATED [ChEBI] synonym: "Zn" RELATED [IUPAC] synonym: "Zn(II)" RELATED [KEGG_COMPOUND] synonym: "Zn2+" RELATED [KEGG_COMPOUND] xref: KEGG:C00038 xref: PDBeChem:ZN xref: WebElements:Zn is_a: CHEBI:33340 ! zinc group element atom relationship: RO:0000087 CHEBI:27027 ! has role micronutrient [Term] id: CHEBI:27364 name: zinc molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc compounds" RELATED [ChEBI] synonym: "zinc molecular entities" RELATED [ChEBI] is_a: CHEBI:33673 ! zinc group molecular entity relationship: BFO:0000051 CHEBI:27363 ! has part zinc atom [Term] id: CHEBI:27369 name: zwitterion namespace: chebi_ontology def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." [] subset: 3_STAR synonym: "compose zwitterionique" RELATED [IUPAC] synonym: "compuestos zwitterionicos" RELATED [IUPAC] synonym: "zwitteriones" RELATED [IUPAC] synonym: "zwitterionic compounds" RELATED [IUPAC] is_a: CHEBI:51151 ! dipolar compound [Term] id: CHEBI:27405 name: streptidine namespace: chebi_ontology alt_id: CHEBI:26781 alt_id: CHEBI:9280 def: "An amino cyclitol that is scyllo-inositol in which the hydroxy groups at positions 1 and 3 are replaced by guanidino groups." [] subset: 3_STAR synonym: "1,1'-(2,4,5,6-Tetrahydroxy-1,3-cyclohexylene)diguanidine" RELATED [ChemIDplus] synonym: "1,3-diguanidino-2,4,5,6-cyclohexanetetrol" RELATED [ChEBI] synonym: "N,N'-bis(aminoiminomethyl)streptamine" RELATED [ChEBI] synonym: "N,N'-diamidinostreptamine" RELATED [ChEBI] synonym: "Streptamine, N,N'-bis(aminoiminomethyl)-" RELATED [ChemIDplus] synonym: "streptidin" RELATED [ChemIDplus] synonym: "Streptidine" EXACT [KEGG_COMPOUND] xref: HMDB:HMDB0258506 xref: KEGG:C00837 xref: MetaCyc:CPD-10148 is_a: CHEBI:24436 ! guanidines is_a: CHEBI:61689 ! amino cyclitol relationship: has_functional_parent CHEBI:10642 ! scyllo-inositol relationship: is_conjugate_base_of CHEBI:184376 ! streptidine(2+) relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:27412 name: gentamycin C1 namespace: chebi_ontology alt_id: CHEBI:24209 alt_id: CHEBI:5309 subset: 3_STAR synonym: "Gentamicin C1" RELATED [KEGG_COMPOUND] synonym: "O-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-ribo-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-D-streptamine" RELATED [ChemIDplus] xref: KEGG:C07656 is_a: CHEBI:28417 ! gentamycin C [Term] id: CHEBI:27561 name: oxirane namespace: chebi_ontology alt_id: CHEBI:24001 alt_id: CHEBI:4900 def: "A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom." [] subset: 3_STAR synonym: "1,2-Epoxyaethan" RELATED [ChemIDplus] synonym: "1,2-epoxyethane" RELATED [NIST_Chemistry_WebBook] synonym: "Aethylenoxid" RELATED [ChemIDplus] synonym: "Amprolene" RELATED [ChemIDplus] synonym: "Anprolene" RELATED [NIST_Chemistry_WebBook] synonym: "Anproline" RELATED [ChemIDplus] synonym: "Dihydrooxirene" RELATED [ChemIDplus] synonym: "Dimethylene oxide" RELATED [ChemIDplus] synonym: "epoxyethane" RELATED [NIST_Chemistry_WebBook] synonym: "ethene oxide" RELATED [NIST_Chemistry_WebBook] synonym: "Ethylene oxide" RELATED [KEGG_COMPOUND] synonym: "ETO" RELATED [ChemIDplus] synonym: "Oxacyclopropane" RELATED [ChemIDplus] synonym: "Oxane" RELATED [ChemIDplus] synonym: "Oxidoethane" RELATED [ChemIDplus] synonym: "oxyde d'ethylene" RELATED [ChemIDplus] synonym: "Oxyfume" RELATED [ChEBI] xref: HMDB:HMDB0031305 xref: KEGG:C06548 xref: KEGG:D03474 xref: Wikipedia:Oxirane is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:36389 ! saturated organic heteromonocyclic parent is_a: CHEBI:38104 ! oxacycle relationship: RO:0000087 CHEBI:25435 ! has role mutagen relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite [Term] id: CHEBI:27565 name: 4-aminosalicylic acid namespace: chebi_ontology alt_id: CHEBI:1789 alt_id: CHEBI:20320 alt_id: CHEBI:41152 def: "An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4." [] subset: 3_STAR synonym: "2-HYDROXY-4-AMINOBENZOIC ACID" RELATED [PDBeChem] synonym: "4-Aminosalicylate" RELATED [KEGG_COMPOUND] synonym: "4-Aminosalicylic acid" EXACT [KEGG_COMPOUND] synonym: "Aminosalicylic acid" RELATED [ChemIDplus] synonym: "p-aminosalicylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Para-amino salicylic acid" RELATED [ChemIDplus] synonym: "PAS" RELATED [ChemIDplus] xref: DrugBank:DB00233 xref: HMDB:HMDB0014378 xref: KEGG:C02518 xref: KEGG:D00162 xref: LINCS:LSM-5862 xref: Patent:DE50835 xref: Patent:US2844625 xref: Patent:US427564 xref: PDBeChem:BHA xref: Wikipedia:Aminosalicylic_Acid is_a: CHEBI:22495 ! aminobenzoic acid is_a: CHEBI:33853 ! phenols relationship: has_functional_parent CHEBI:16914 ! salicylic acid relationship: is_conjugate_acid_of CHEBI:137598 ! 4-aminosalicylate(1-) relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent [Term] id: CHEBI:27594 name: carbon atom namespace: chebi_ontology alt_id: CHEBI:23009 alt_id: CHEBI:3399 subset: 3_STAR synonym: "6C" RELATED [IUPAC] synonym: "C" RELATED [IUPAC, KEGG_COMPOUND] synonym: "Carbon" RELATED [KEGG_COMPOUND] synonym: "carbon" RELATED [ChEBI] synonym: "carbone" RELATED [ChEBI] synonym: "carbonium" RELATED [ChEBI] synonym: "carbono" RELATED [ChEBI] synonym: "Kohlenstoff" RELATED [ChEBI] xref: KEGG:C06265 xref: WebElements:C is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33306 ! carbon group element atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:2762 name: antimycin A namespace: chebi_ontology alt_id: CHEBI:22584 alt_id: CHEBI:40908 def: "A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison." [] subset: 3_STAR synonym: "Antimycin A1" RELATED [KEGG_COMPOUND] synonym: "antimycin A1b" RELATED [ChEBI] synonym: "Antipiricullin" RELATED [ChemIDplus] synonym: "Fintrol" RELATED [ChemIDplus] synonym: "Virosin" RELATED [ChemIDplus] xref: KEGG:C11339 xref: MetaCyc:CPD-5744 xref: PDBeChem:AY1 is_a: CHEBI:145556 ! macrodiolide is_a: CHEBI:22702 ! benzamides is_a: CHEBI:24079 ! formamides is_a: CHEBI:33853 ! phenols relationship: RO:0000087 CHEBI:167183 ! has role piscicide relationship: RO:0000087 CHEBI:25355 ! has role mitochondrial respiratory-chain inhibitor relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:27641 name: cycloheximide namespace: chebi_ontology alt_id: CHEBI:23484 alt_id: CHEBI:4015 def: "A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus." [] subset: 3_STAR synonym: "3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide" RELATED [ChemIDplus] synonym: "Cycloheximid" RELATED [ChEBI] synonym: "Cycloheximide" EXACT [KEGG_COMPOUND] synonym: "cycloheximide" EXACT [UniProt] synonym: "naramycin" RELATED [ChemIDplus] synonym: "naramycin A" RELATED [ChemIDplus] synonym: "Zykloheximid" RELATED [ChEBI] xref: KEGG:C06685 xref: KEGG:D03625 xref: KNApSAcK:C00047211 xref: LINCS:LSM-2791 xref: PDBeChem:3HE xref: PPDB:1680 xref: Wikipedia:Cycloheximide is_a: CHEBI:35356 ! dicarboximide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:48589 ! piperidones is_a: CHEBI:49318 ! piperidine antibiotic is_a: CHEBI:87114 ! antibiotic fungicide relationship: has_functional_parent CHEBI:5435 ! piperidine-2,6-dione relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:173084 ! has role ferroptosis inhibitor relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:27644 name: chlortetracycline namespace: chebi_ontology alt_id: CHEBI:23164 alt_id: CHEBI:3653 def: "A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens." [] subset: 3_STAR synonym: "7-Chlorotetracycline" RELATED [KEGG_COMPOUND] xref: HMDB:HMDB0014401 xref: KEGG:C06571 xref: KEGG:D07689 xref: Patent:US2482055 xref: PDBeChem:CTC is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:83403 ! monochlorobenzenes relationship: is_conjugate_acid_of CHEBI:133598 ! chlortetracycline(1-) relationship: RO:0000087 CHEBI:22986 ! has role calcium ionophore relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:39442 ! has role fluorescent probe [Term] id: CHEBI:27656 name: camptothecin namespace: chebi_ontology alt_id: CHEBI:22997 alt_id: CHEBI:3343 def: "A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer)." [] subset: 3_STAR synonym: "(+)-camptothecin" RELATED [DrugBank] synonym: "(+)-camptothecine" RELATED [DrugBank] synonym: "(S)-(+)-camptothecin" RELATED [DrugBank] synonym: "20(S)-camptothecine" RELATED [ChemIDplus] synonym: "21,22-Secocamptothecin-21-oic acid lactone" RELATED [ChemIDplus] synonym: "Camptothecin" EXACT [KEGG_COMPOUND] synonym: "Camptothecine" RELATED [ChemIDplus] synonym: "CPT" RELATED [DrugBank] synonym: "D-camptothecin" RELATED [DrugBank] xref: DrugBank:DB04690 xref: KEGG:C01897 xref: KNApSAcK:C00002145 xref: LINCS:LSM-4611 xref: PDBeChem:EHD xref: Wikipedia:Camptothecin is_a: CHEBI:18946 ! delta-lactone is_a: CHEBI:26509 ! quinoline alkaloid is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:48626 ! pyranoindolizinoquinoline relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:50276 ! has role EC 5.99.1.2 (DNA topoisomerase) inhibitor relationship: RO:0000087 CHEBI:50902 ! has role genotoxin relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:27666 name: actinomycin D namespace: chebi_ontology alt_id: CHEBI:22218 alt_id: CHEBI:2446 subset: 3_STAR synonym: "2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide" RELATED [ChemIDplus] synonym: "ActD" RELATED [ChEBI] synonym: "actinomycin C1" RELATED [ChEBI] synonym: "Actinomycin D" EXACT [KEGG_COMPOUND] synonym: "actinomycin IV" RELATED [ChemIDplus] synonym: "Dactinomycin" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00970 xref: KEGG:C06770 xref: KEGG:D00214 xref: LINCS:LSM-5783 xref: Wikipedia:Dactinomycin is_a: CHEBI:15369 ! actinomycin relationship: RO:0000087 CHEBI:25435 ! has role mutagen [Term] id: CHEBI:27701 name: oxytetracycline namespace: chebi_ontology alt_id: CHEBI:25811 alt_id: CHEBI:521157 alt_id: CHEBI:596903 alt_id: CHEBI:7871 def: "A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae." [] subset: 3_STAR synonym: "5-Hydroxytetracycline" RELATED [ChemIDplus] synonym: "Oxyterracin" RELATED [ChemIDplus] synonym: "Oxyterracine" RELATED [ChemIDplus] synonym: "Oxytetracyclin" RELATED [ChemIDplus] synonym: "Oxytetracycline (anhydrous)" RELATED [ChemIDplus] synonym: "Oxytetracycline amphoteric" RELATED [ChemIDplus] xref: BPDB:503 xref: DrugBank:DB00595 xref: HMDB:HMDB0014733 xref: KEGG:C06624 xref: KNApSAcK:C00017127 xref: VSDB:503 xref: Wikipedia:Oxytetracycline is_a: CHEBI:26895 ! tetracyclines relationship: is_tautomer_of CHEBI:133011 ! oxytetracycline zwitterion relationship: RO:0000087 CHEBI:35472 ! has role anti-inflammatory drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:27780 name: detergent namespace: chebi_ontology alt_id: CHEBI:23648 alt_id: CHEBI:4456 def: "A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions." [] subset: 3_STAR synonym: "Detergents" RELATED [KEGG_COMPOUND] xref: KEGG:C01689 is_a: CHEBI:33232 ! application is_a: CHEBI:35195 ! surfactant [Term] id: CHEBI:27822 name: 2-aminobenzimidazole namespace: chebi_ontology alt_id: CHEBI:1016 alt_id: CHEBI:19467 def: "A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group." [] subset: 3_STAR synonym: "2-Aminobenzimidazole" EXACT [KEGG_COMPOUND] synonym: "2-aminobenzimidazole" EXACT [UniProt] synonym: "2-Iminobenzimidazoline" RELATED [ChemIDplus] synonym: "Benzimidazol-2-ylamine" RELATED [ChemIDplus] xref: KEGG:C10901 xref: PDBeChem:AX7 is_a: CHEBI:22715 ! benzimidazoles relationship: RO:0000087 CHEBI:83399 ! has role marine xenobiotic metabolite [Term] id: CHEBI:27881 name: resveratrol namespace: chebi_ontology alt_id: CHEBI:11685 alt_id: CHEBI:1366 alt_id: CHEBI:19867 def: "A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups." [] subset: 3_STAR synonym: "3,4',5-Trihydroxystilbene" RELATED [KEGG_COMPOUND] synonym: "Resveratrol" EXACT [KEGG_COMPOUND] xref: DrugBank:DB02709 xref: KEGG:C03582 xref: LINCS:LSM-2557 is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:33572 ! resorcinols is_a: CHEBI:36027 ! stilbenol relationship: RO:0000087 CHEBI:140922 ! has role glioma-associated oncogene inhibitor relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:22586 ! has role antioxidant relationship: RO:0000087 CHEBI:26115 ! has role phytoalexin [Term] id: CHEBI:27902 name: tetracycline namespace: chebi_ontology alt_id: CHEBI:26894 alt_id: CHEBI:45729 alt_id: CHEBI:9474 def: "A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria." [] subset: 3_STAR synonym: "(4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide" RELATED [ChemIDplus] synonym: "Abramycin" RELATED [ChemIDplus] synonym: "Achromycin" RELATED [ChEBI] synonym: "Anhydrotetracycline" RELATED [DrugBank] synonym: "Deschlorobiomycin" RELATED [ChemIDplus] synonym: "Liquamycin" RELATED [ChemIDplus] synonym: "Tetracyclin" RELATED [ChEBI] synonym: "TETRACYCLINE" EXACT [PDBeChem] synonym: "Tetracycline" EXACT [KEGG_COMPOUND] synonym: "tetracycline" EXACT [ChEBI] synonym: "Tetrazyklin" RELATED [ChEBI] synonym: "Tsiklomitsin" RELATED [ChemIDplus] xref: DrugBank:DB00759 xref: KEGG:C06570 xref: KEGG:D00201 xref: MetaCyc:CPD0-1414 xref: Patent:US2699054 xref: Patent:US2712517 xref: Patent:US2886595 xref: Patent:US3005023 xref: Patent:US3019173 xref: Patent:US3301899 xref: PDBeChem:TAC xref: VSDB:1739 xref: Wikipedia:Tetracycline is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines relationship: is_tautomer_of CHEBI:77932 ! tetracycline zwitterion relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:27933 name: beta-lactam antibiotic namespace: chebi_ontology alt_id: CHEBI:10427 alt_id: CHEBI:22844 def: "An organonitrogen heterocyclic antibiotic that contains a beta-lactam ring." [] subset: 3_STAR synonym: "beta-Lactam antibiotics" RELATED [KEGG_COMPOUND] synonym: "beta-lactam antibiotics" RELATED [ChEBI] xref: KEGG:C03438 xref: Wikipedia:Beta-lactam_antibiotic is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:35627 ! beta-lactam [Term] id: CHEBI:27955 name: streptamine namespace: chebi_ontology alt_id: CHEBI:26779 alt_id: CHEBI:9277 def: "An amino cyclitol consisting of scyllo-inositol with the hydroxy groups at positions 1 and 3 replaced by unsubstituted amino groups." [] subset: 3_STAR synonym: "Streptamine" EXACT [KEGG_COMPOUND] xref: KEGG:C01854 is_a: CHEBI:61689 ! amino cyclitol relationship: has_functional_parent CHEBI:10642 ! scyllo-inositol [Term] id: CHEBI:28001 name: vancomycin namespace: chebi_ontology alt_id: CHEBI:27276 alt_id: CHEBI:49941 alt_id: CHEBI:9931 def: "A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile." [] subset: 3_STAR synonym: "(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid" RELATED [ChEBI] synonym: "(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):C(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]" RELATED [JCBN] synonym: "vancomicin" RELATED [ChEBI] synonym: "VANCOMYCIN" EXACT [PDBeChem] synonym: "Vancomycin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00512 xref: KEGG:C06689 xref: KEGG:D00212 xref: KNApSAcK:C00016052 xref: MetaCyc:CPD-12245 xref: Patent:US3067099 xref: PDBeChem:VAN xref: Wikipedia:Vancomycin is_a: CHEBI:24396 ! glycopeptide relationship: has_functional_parent CHEBI:47724 ! vancomycin aglycone relationship: is_conjugate_base_of CHEBI:76842 ! vancomycin(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:28077 name: rifampicin namespace: chebi_ontology alt_id: CHEBI:26577 alt_id: CHEBI:45308 alt_id: CHEBI:8858 def: "A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)." [] subset: 3_STAR synonym: "3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV" RELATED [ChemIDplus] synonym: "RFP" RELATED [DrugBank] synonym: "rifamcin" RELATED [ChEBI] synonym: "Rifampicin" EXACT [KEGG_COMPOUND] synonym: "Rifampin" RELATED [KEGG_COMPOUND] xref: DrugBank:DB01045 xref: HMDB:HMDB0015179 xref: KEGG:C06688 xref: KEGG:D00211 xref: Patent:NL6509961 xref: Patent:US3342810 xref: PDBeChem:RFP xref: Wikipedia:Rifampicin is_a: CHEBI:26580 ! rifamycins is_a: CHEBI:38532 ! hydrazone is_a: CHEBI:46847 ! N-iminopiperazine is_a: CHEBI:46920 ! N-methylpiperazine is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:72588 ! semisynthetic derivative relationship: is_tautomer_of CHEBI:71365 ! rifampicin zwitterion relationship: RO:0000087 CHEBI:171664 ! has role antiamoebic agent relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug relationship: RO:0000087 CHEBI:37416 ! has role EC 2.7.7.6 (RNA polymerase) inhibitor relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:48422 ! has role angiogenesis inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77318 ! has role pregnane X receptor agonist [Term] id: CHEBI:28079 name: beta-L-arabinoside namespace: chebi_ontology alt_id: CHEBI:10422 alt_id: CHEBI:22818 subset: 3_STAR synonym: "beta-L-Arabinoside" EXACT [KEGG_COMPOUND] synonym: "beta-L-arabinosides" RELATED [ChEBI] xref: KEGG:C02761 is_a: CHEBI:22601 ! arabinoside [Term] id: CHEBI:28084 name: 3-(carbamoyloxymethyl)cephalosporin namespace: chebi_ontology alt_id: CHEBI:1462 alt_id: CHEBI:19970 subset: 3_STAR synonym: "3-(carbamoyloxymethyl)cephalosporins" RELATED [ChEBI] synonym: "3-Carbamoyloxymethylcephem" RELATED [KEGG_COMPOUND] xref: KEGG:C03674 is_a: CHEBI:23066 ! cephalosporin [Term] id: CHEBI:28098 name: kanamycin B namespace: chebi_ontology alt_id: CHEBI:14489 alt_id: CHEBI:24948 alt_id: CHEBI:24949 alt_id: CHEBI:6107 subset: 3_STAR synonym: "2'-amino-2'-deoxykanamycin" RELATED [ChemIDplus] synonym: "Bekanamycin" RELATED [KEGG_COMPOUND] synonym: "Kanamycin B" EXACT [KEGG_COMPOUND] synonym: "Nebramycin factor 5" RELATED [KEGG_COMPOUND] synonym: "Nebramycin V" RELATED [ChemIDplus] synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->6))-2-deoxy-D-streptamine" RELATED [ChemIDplus] xref: KEGG:C00825 xref: KEGG:D07497 xref: KNApSAcK:C00018692 xref: PDBeChem:9CS is_a: CHEBI:24951 ! kanamycins relationship: is_conjugate_base_of CHEBI:58549 ! kanamycin B(5+) [Term] id: CHEBI:28201 name: rotenone namespace: chebi_ontology alt_id: CHEBI:26583 alt_id: CHEBI:8897 def: "A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica)." [] subset: 3_STAR synonym: "(-)-cis-rotenone" RELATED [ChemIDplus] synonym: "(-)-rotenone" RELATED [ChemIDplus] synonym: "(12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one" RELATED [ChEBI] synonym: "5'beta-rotenone" RELATED [NIST_Chemistry_WebBook] synonym: "[2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one" RELATED [NIST_Chemistry_WebBook] synonym: "barbasco" RELATED [ChemIDplus] synonym: "canex" RELATED [ChemIDplus] synonym: "dactinol" RELATED [ChemIDplus] synonym: "Derris" RELATED [ChEBI] synonym: "noxfire" RELATED [ChemIDplus] synonym: "paraderil" RELATED [ChemIDplus] synonym: "Rotenone" EXACT [KEGG_COMPOUND] synonym: "tubatoxin" RELATED [ChemIDplus] xref: BPDB:587 xref: DrugBank:DB11457 xref: FooDB:FDB012837 xref: HMDB:HMDB0034436 xref: KEGG:C07593 xref: KNApSAcK:C00002568 xref: LINCS:LSM-5260 xref: Patent:CN102007944 xref: Patent:CN102090406 xref: PDBeChem:970 xref: VSDB:587 xref: Wikipedia:Rotenone is_a: CHEBI:38164 ! organic heteropentacyclic compound is_a: CHEBI:72581 ! rotenones relationship: RO:0000087 CHEBI:167183 ! has role piscicide relationship: RO:0000087 CHEBI:22917 ! has role phytogenic insecticide relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:38498 ! has role mitochondrial NADH:ubiquinone reductase inhibitor [Term] id: CHEBI:28240 name: dichloroacetate namespace: chebi_ontology alt_id: CHEBI:23694 def: "A monocarboxylic acid anion that is the conjugate base of dichloroacetic acid." [] subset: 3_STAR synonym: "dichloracetate" RELATED [ChemIDplus] synonym: "dichloroacetate ion" RELATED [ChemIDplus] synonym: "dichloroacetic acid ion(1-)" RELATED [ChemIDplus] xref: MetaCyc:CPD-9674 is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: has_functional_parent CHEBI:30089 ! acetate relationship: is_conjugate_base_of CHEBI:36386 ! dichloroacetic acid relationship: RO:0000087 CHEBI:176497 ! has role geroprotector [Term] id: CHEBI:28306 name: semicarbazide namespace: chebi_ontology alt_id: CHEBI:26644 alt_id: CHEBI:9102 def: "A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine." [] subset: 3_STAR synonym: "Aminoharnstoff" RELATED [ChEBI] synonym: "Aminourea" RELATED [KEGG_COMPOUND] synonym: "Carbamidsaeurehydrazid" RELATED [ChEBI] synonym: "Carbamoylhydrazine" RELATED [KEGG_COMPOUND] synonym: "carbamylhydrazine" RELATED [ChemIDplus] synonym: "carbazamide" RELATED [ChemIDplus] synonym: "Hydrazinecarboxamide" RELATED [KEGG_COMPOUND] synonym: "Semicarbazide" EXACT [KEGG_COMPOUND] synonym: "Semikarbazid" RELATED [NIST_Chemistry_WebBook] xref: KEGG:C02077 xref: MetaCyc:SEMICARBAZIDE xref: Wikipedia:Semicarbazide is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:35363 ! carbohydrazide is_a: CHEBI:47857 ! ureas is_a: CHEBI:64708 ! one-carbon compound [Term] id: CHEBI:28368 name: novobiocin namespace: chebi_ontology alt_id: CHEBI:25597 alt_id: CHEBI:44505 alt_id: CHEBI:7644 def: "A coumarin-derived antibiotic obtained from Streptomyces niveus." [] subset: 3_STAR synonym: "N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide" RELATED [ChEBI] synonym: "Novobiocin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB01051 xref: HMDB:HMDB0015185 xref: KEGG:C05080 xref: KNApSAcK:C00002487 xref: LINCS:LSM-5910 xref: Patent:WO2012049521 xref: Patent:WO2012103487 xref: PDBeChem:NOV is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:25698 ! ether is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33853 ! phenols is_a: CHEBI:35313 ! hexoside is_a: CHEBI:37912 ! hydroxycoumarin is_a: CHEBI:63367 ! monosaccharide derivative relationship: is_conjugate_acid_of CHEBI:71339 ! novobiocin(1-) relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:62868 ! has role hepatoprotective agent relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:28417 name: gentamycin C namespace: chebi_ontology alt_id: CHEBI:14294 alt_id: CHEBI:24208 alt_id: CHEBI:5308 subset: 3_STAR synonym: "Gentamicin C" RELATED [KEGG_COMPOUND] xref: KEGG:C01918 is_a: CHEBI:17833 ! gentamycin relationship: is_conjugate_base_of CHEBI:75616 ! gentamicin C(5+) [Term] id: CHEBI:28545 name: valinomycin namespace: chebi_ontology alt_id: CHEBI:27269 alt_id: CHEBI:66347 alt_id: CHEBI:9924 def: "A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains." [] subset: 3_STAR synonym: "Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)" RELATED [ChemIDplus] synonym: "cyclo[-D-O-Val-D-Val-L-O-Ala-L-Val]3" RELATED [ChEBI] synonym: "Valinomycin" EXACT [KEGG_COMPOUND] xref: KEGG:C06684 xref: Wikipedia:Valinomycin is_a: CHEBI:35213 ! cyclodepsipeptide is_a: CHEBI:51026 ! macrocycle relationship: RO:0000087 CHEBI:22587 ! has role antiviral agent relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite relationship: RO:0000087 CHEBI:88227 ! has role potassium ionophore [Term] id: CHEBI:28600 name: farnesol namespace: chebi_ontology alt_id: CHEBI:24013 alt_id: CHEBI:24014 alt_id: CHEBI:4978 def: "A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1." [] subset: 3_STAR synonym: "3,7,11-trimethyl-2,6,10-dodecatrien-1-ol" RELATED [ChemIDplus] synonym: "3,7,11-trimethyl-2,6,10-dodecatrienol" RELATED [NIST_Chemistry_WebBook] synonym: "Farnesol" EXACT [KEGG_COMPOUND] synonym: "farnesol" EXACT [UniProt] synonym: "farnesyl alcohol" RELATED [NIST_Chemistry_WebBook] xref: DrugBank:DB02509 xref: HMDB:HMDB0004305 xref: KEGG:C01493 xref: KNApSAcK:C00003132 xref: LINCS:LSM-5398 is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:26199 ! polyprenol is_a: CHEBI:36757 ! farnesane sesquiterpenoid relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite [Term] id: CHEBI:28616 name: carbamic acid namespace: chebi_ontology alt_id: CHEBI:22504 alt_id: CHEBI:23002 alt_id: CHEBI:3386 alt_id: CHEBI:44573 def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." [] subset: 3_STAR synonym: "Aminoameisensaeure" RELATED [ChEBI] synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND] synonym: "Carbamate" RELATED [KEGG_COMPOUND] synonym: "CARBAMIC ACID" EXACT [PDBeChem] synonym: "Carbamic acid" EXACT [KEGG_COMPOUND] synonym: "Carbamidsaeure" RELATED [ChEBI] xref: DrugBank:DB04261 xref: KEGG:C01563 xref: PDBeChem:OUT xref: Wikipedia:Carbamic_acid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:64708 ! one-carbon compound relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:28659 name: phosphorus atom namespace: chebi_ontology alt_id: CHEBI:26080 alt_id: CHEBI:8168 subset: 3_STAR synonym: "15P" RELATED [IUPAC] synonym: "fosforo" RELATED [ChEBI] synonym: "P" RELATED [IUPAC, KEGG_COMPOUND] synonym: "Phosphor" RELATED [ChEBI] synonym: "phosphore" RELATED [ChEBI] synonym: "Phosphorus" RELATED [KEGG_COMPOUND] synonym: "phosphorus" RELATED [ChEBI] xref: KEGG:C06262 xref: WebElements:P is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33300 ! pnictogen relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:28669 name: bacitracin namespace: chebi_ontology alt_id: CHEBI:22684 alt_id: CHEBI:2970 def: "A mixture of at least nine closely related homodetic cyclic peptides produced by Bacillus subtilis and B. licheniformis, which is particularly active against Gram-positive bacteria." [] subset: 3_STAR synonym: "Bacitracin" EXACT [KEGG_COMPOUND] synonym: "bacitracins" RELATED [ChEBI] xref: DrugBank:DB00626 xref: KEGG:C01667 xref: KEGG:D00128 xref: Wikipedia:Bacitracin is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:35862 ! has part bacitracin A relationship: is_tautomer_of CHEBI:184381 ! bacitracin A zwitterion relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:28694 name: copper atom namespace: chebi_ontology alt_id: CHEBI:23376 alt_id: CHEBI:3874 subset: 3_STAR synonym: "29Cu" RELATED [IUPAC] synonym: "cobre" RELATED [ChEBI] synonym: "Copper" RELATED [KEGG_COMPOUND] synonym: "copper" RELATED [ChEBI] synonym: "Cu" RELATED [ChEBI, IUPAC] synonym: "cuivre" RELATED [ChEBI] synonym: "cuprum" RELATED [IUPAC] synonym: "Kupfer" RELATED [ChEBI] xref: KEGG:C00070 xref: WebElements:Cu is_a: CHEBI:33366 ! copper group element atom is_a: CHEBI:88184 ! metal allergen relationship: RO:0000087 CHEBI:27027 ! has role micronutrient relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:28817 name: dodecane namespace: chebi_ontology alt_id: CHEBI:25464 alt_id: CHEBI:41713 alt_id: CHEBI:4675 def: "A straight-chain alkane with 12 carbon atoms. It has been isolated from the essential oils of various plants including Zingiber officinale (ginger)." [] subset: 3_STAR synonym: "Bihexyl" RELATED [HMDB] synonym: "CH3-[CH2]10-CH3" RELATED [IUPAC] synonym: "Dihexyl" RELATED [HMDB] synonym: "DODECANE" EXACT [PDBeChem] synonym: "Dodecane" EXACT [KEGG_COMPOUND] synonym: "dodecane" EXACT [UniProt] synonym: "Dodekan" RELATED [ChEBI] synonym: "n-Dodecane" RELATED [KEGG_COMPOUND] xref: DrugBank:DB02771 xref: HMDB:HMDB0031444 xref: KEGG:C08374 xref: KNApSAcK:C00001248 xref: MetaCyc:CPD-9290 xref: PDBeChem:D12 xref: Wikipedia:Dodecane is_a: CHEBI:18310 ! alkane relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:28864 name: tobramycin namespace: chebi_ontology alt_id: CHEBI:19849 alt_id: CHEBI:45933 alt_id: CHEBI:9610 def: "A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring." [] subset: 3_STAR synonym: "3'-Deoxykanamycin B" RELATED [KEGG_COMPOUND] synonym: "Nebramycin 6" RELATED [ChemIDplus] synonym: "Nebramycin factir 6" RELATED [KEGG_COMPOUND] synonym: "O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine" RELATED [ChemIDplus] synonym: "Tobracin (TN)" RELATED [KEGG_DRUG] synonym: "Tobramycin" EXACT [KEGG_COMPOUND] synonym: "Tobrex (TN)" RELATED [KEGG_DRUG] xref: DrugBank:DB00684 xref: KEGG:C00397 xref: KEGG:D00063 xref: LINCS:LSM-6534 xref: PDBeChem:TOY xref: Wikipedia:Tobramycin is_a: CHEBI:22479 ! amino cyclitol glycoside relationship: has_functional_parent CHEBI:28098 ! kanamycin B relationship: is_conjugate_base_of CHEBI:73678 ! tobramycin(5+) relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:28866 name: tetracosanoic acid namespace: chebi_ontology alt_id: CHEBI:25467 alt_id: CHEBI:26892 alt_id: CHEBI:6458 def: "A C24 straight-chain saturated fatty acid." [] subset: 3_STAR synonym: "CH3-[CH2]22-COOH" RELATED [IUPAC] synonym: "Lignoceric acid" RELATED [KEGG_COMPOUND] synonym: "Lignozerinsaeure" RELATED [ChEBI] synonym: "n-tetracosanoic acid" RELATED [ChEBI] synonym: "tetracosanic acid" RELATED [ChEBI] synonym: "Tetracosanoic acid" EXACT [KEGG_COMPOUND] synonym: "Tetracosansaeure" RELATED [ChEBI] synonym: "tetracosoic acid" RELATED [ChEBI] synonym: "tetraeicosanoic acid" RELATED [ChEBI] synonym: "tetraicosanoic acid" RELATED [ChEBI] xref: HMDB:HMDB0002003 xref: KEGG:C08320 xref: KNApSAcK:C00001223 xref: MetaCyc:TETRACOSANOATE xref: Wikipedia:Lignoceric_acid is_a: CHEBI:27283 ! very long-chain fatty acid is_a: CHEBI:39418 ! straight-chain saturated fatty acid relationship: is_conjugate_acid_of CHEBI:31014 ! tetracosanoate relationship: RO:0000087 CHEBI:27311 ! has role volatile oil component relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:83146 ! has role Daphnia tenebrosa metabolite [Term] id: CHEBI:28868 name: fatty acid anion namespace: chebi_ontology alt_id: CHEBI:13634 alt_id: CHEBI:24022 alt_id: CHEBI:4985 def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." [] subset: 3_STAR synonym: "a fatty acid" RELATED [UniProt] synonym: "acido graso anionico" RELATED [ChEBI] synonym: "acidos grasos anionicos" RELATED [ChEBI] synonym: "Alkanate" RELATED [KEGG_COMPOUND] synonym: "anion de l'acide gras" RELATED [ChEBI] synonym: "Fatty acid anion" EXACT [KEGG_COMPOUND] synonym: "fatty acid anions" RELATED [ChEBI] synonym: "Fettsaeureanion" RELATED [ChEBI] synonym: "Fettsaeureanionen" RELATED [ChEBI] xref: KEGG:C02403 is_a: CHEBI:18059 ! lipid is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:35366 ! fatty acid [Term] id: CHEBI:28909 name: iprodione namespace: chebi_ontology alt_id: CHEBI:24871 alt_id: CHEBI:8902 def: "An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide." [] subset: 3_STAR synonym: "3-(3,5-dichlorophenyl)-1-(1-methylethyl)carbamoylhydantoin" RELATED [NIST_Chemistry_WebBook] synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide" RELATED [ChemIDplus, UM-BBD] synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxoimidazolidine-1-carboxamide" RELATED [IUPAC] synonym: "3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide" RELATED [ChemIDplus] synonym: "3-(3,5-dichlorophenyl)hydantoin-1-carboxylic acid isopropylamide" RELATED [ChemIDplus] synonym: "Iprodione" EXACT [KEGG_COMPOUND] synonym: "Rovral" RELATED [KEGG_COMPOUND] synonym: "Rovrol" RELATED [KEGG_COMPOUND] xref: HMDB:HMDB0031795 xref: KEGG:C11208 xref: Patent:CN103053579 xref: Patent:CN103392726 xref: Patent:DE2149923 xref: Patent:US3755350 xref: PPDB:403 xref: Wikipedia:Iprodione is_a: CHEBI:24628 ! imidazolidine-2,4-dione is_a: CHEBI:47857 ! ureas is_a: CHEBI:87068 ! imidazole fungicide is_a: CHEBI:87197 ! dichlorophenyl dicarboximide fungicide relationship: RO:0000087 CHEBI:25491 ! has role nematicide relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:28915 name: fosfomycin namespace: chebi_ontology alt_id: CHEBI:24100 alt_id: CHEBI:42503 alt_id: CHEBI:8159 def: "A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus." [] subset: 3_STAR synonym: "(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid" RELATED [ChemIDplus] synonym: "(1R,2S)-epoxypropylphosphonic acid" RELATED [MetaCyc] synonym: "(2R-cis)-(3-Methyloxiranyl)phosphonic acid" RELATED [ChemIDplus] synonym: "1R-cis-(1,2-epoxypropyl)phosphonic acid" RELATED [ChEBI] synonym: "cis-(1R,2S)-epoxypropylphosphonic acid" RELATED [MetaCyc] synonym: "FCM" RELATED [KEGG_DRUG] synonym: "FOSFOMYCIN" EXACT [PDBeChem] synonym: "L-cis-1,2-epoxypropylphosphonic acid" RELATED [MetaCyc] synonym: "Phosphomycin" RELATED [ChemIDplus] synonym: "phosphonemycin" RELATED [MetaCyc] synonym: "Phosphonomycin" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00828 xref: KEGG:C06454 xref: KEGG:D04253 xref: KNApSAcK:C00000789 xref: MetaCyc:CPD0-1113 xref: PDBeChem:FCN is_a: CHEBI:26069 ! phosphonic acids is_a: CHEBI:32955 ! epoxide relationship: has_functional_parent CHEBI:44976 ! phosphonic acid relationship: is_conjugate_acid_of CHEBI:62247 ! (1R,2S)-epoxypropylphosphonate(1-) relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:78379 ! has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor [Term] id: CHEBI:28938 name: ammonium namespace: chebi_ontology alt_id: CHEBI:22534 alt_id: CHEBI:49783 alt_id: CHEBI:7435 def: "An onium cation obtained by protonation of ammonia." [] subset: 3_STAR synonym: "[NH4](+)" RELATED [MolBase] synonym: "ammonium" EXACT [ChEBI] synonym: "ammonium cation" RELATED [ChemIDplus] synonym: "ammonium ion" RELATED [PDBeChem] synonym: "Ammonium(1+)" RELATED [ChemIDplus] synonym: "NH4(+)" RELATED [IUPAC, UniProt] synonym: "NH4+" RELATED [KEGG_COMPOUND] xref: KEGG:C01342 xref: MetaCyc:AMMONIUM xref: MolBase:929 xref: PDBeChem:NH4 xref: Wikipedia:Ammonium is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:50313 ! onium cation is_a: CHEBI:60242 ! monovalent inorganic cation relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:28963 name: amino sugar namespace: chebi_ontology alt_id: CHEBI:22481 alt_id: CHEBI:22530 alt_id: CHEBI:2662 def: "Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." [] subset: 3_STAR synonym: "amino sugars" RELATED [ChEBI] synonym: "aminosugar" RELATED [ChEBI] synonym: "Aminosugars" RELATED [KEGG_COMPOUND] xref: KEGG:C05383 is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:28965 name: dicarboxylic acid dianion namespace: chebi_ontology alt_id: CHEBI:13632 alt_id: CHEBI:23688 alt_id: CHEBI:23689 alt_id: CHEBI:38711 def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." [] subset: 3_STAR synonym: "a dicarboxylate" RELATED [UniProt] synonym: "dicarboxylate" RELATED [ChEBI] synonym: "dicarboxylates" RELATED [ChEBI] synonym: "dicarboxylic acid dianion" EXACT [ChEBI] synonym: "dicarboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:35693 ! dicarboxylic acid anion is_a: CHEBI:38716 ! carboxylic acid dianion [Term] id: CHEBI:28971 name: ampicillin namespace: chebi_ontology alt_id: CHEBI:22536 alt_id: CHEBI:2683 alt_id: CHEBI:40648 alt_id: CHEBI:45042 def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID" RELATED [PDBeChem] synonym: "(2S,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [PDBeChem] synonym: "6-(D-(2-amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid" RELATED [ChemIDplus] synonym: "ABPC" RELATED [ChEBI] synonym: "aminobenzylpenicillin" RELATED [DrugBank] synonym: "AMP" RELATED [ChEBI] synonym: "Ampicillin" EXACT [KEGG_COMPOUND] synonym: "ampicillin acid" RELATED [DrugBank] synonym: "ampicillin anhydrous" RELATED [DrugBank] synonym: "Anhydrous ampicillin" RELATED [KEGG_COMPOUND] synonym: "AP" RELATED [ChEBI] synonym: "D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid" RELATED [ChemIDplus] synonym: "D-(-)-ampicillin" RELATED [ChemIDplus] xref: DrugBank:DB00415 xref: HMDB:HMDB0014559 xref: KEGG:C06574 xref: KEGG:D00204 xref: LINCS:LSM-5761 xref: Patent:GB902703 xref: Patent:US2985648 xref: Patent:US3157640 xref: PDB:1H8S xref: PDBeChem:AIC xref: PDBeChem:PN1 xref: VSDB:1849 xref: Wikipedia:Ampicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:50658 ! ampicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:28976 name: carbonic acid namespace: chebi_ontology alt_id: CHEBI:13351 alt_id: CHEBI:23017 alt_id: CHEBI:23744 alt_id: CHEBI:3401 subset: 3_STAR synonym: "[CO(OH)2]" RELATED [IUPAC] synonym: "Carbonic acid" EXACT [KEGG_COMPOUND] synonym: "Dihydrogen carbonate" RELATED [KEGG_COMPOUND] synonym: "H2CO3" RELATED [IUPAC, KEGG_COMPOUND] synonym: "Koehlensaeure" RELATED [ChEBI] xref: KEGG:C01353 xref: PDBeChem:CO3 is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36961 ! chalcocarbonic acid relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite [Term] id: CHEBI:29007 name: ceftriaxone namespace: chebi_ontology alt_id: CHEBI:23059 alt_id: CHEBI:3513 alt_id: CHEBI:446214 def: "A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "rocephin" RELATED [ChEBI] xref: DrugBank:DB01212 xref: HMDB:HMDB0015343 xref: KEGG:C06683 xref: KEGG:D07659 xref: MetaCyc:CPD-12294 xref: Patent:GB2022090 xref: Patent:US4327210 xref: Wikipedia:Ceftriaxone is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether is_a: CHEBI:38418 ! 1,3-thiazoles is_a: CHEBI:39410 ! 1,2,4-triazines relationship: is_conjugate_acid_of CHEBI:53658 ! ceftriaxone(1-) relationship: RO:0000087 CHEBI:35625 ! has role EC 3.5.2.6 (beta-lactamase) inhibitor relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:29013 name: fusidic acid namespace: chebi_ontology alt_id: CHEBI:24133 alt_id: CHEBI:42742 alt_id: CHEBI:5201 def: "A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum." [] subset: 3_STAR synonym: "fucidic acid" RELATED [ChEBI] synonym: "Fucidin acid" RELATED [ChemIDplus] synonym: "Fusidic acid" EXACT [KEGG_COMPOUND] synonym: "Fusidine" RELATED [ChemIDplus] synonym: "Ramycin" RELATED [ChemIDplus] xref: DrugBank:DB02703 xref: HMDB:HMDB0015570 xref: KEGG:C06694 xref: KEGG:D04281 xref: KNApSAcK:C00023903 xref: MetaCyc:CPD0-1606 xref: PDBeChem:FUA xref: VSDB:1776 xref: Wikipedia:Fusidic_acid is_a: CHEBI:19129 ! 11alpha-hydroxy steroid is_a: CHEBI:26761 ! steroid antibiotic is_a: CHEBI:35915 ! sterol ester is_a: CHEBI:36835 ! 3alpha-hydroxy steroid is_a: CHEBI:47891 ! steroid acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid relationship: has_parent_hydride CHEBI:35515 ! 5alpha-cholestane relationship: is_conjugate_acid_of CHEBI:71321 ! fusidate relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77194 ! has role EC 2.7.1.33 (pantothenate kinase) inhibitor [Term] id: CHEBI:29036 name: copper(2+) namespace: chebi_ontology alt_id: CHEBI:20882 alt_id: CHEBI:23380 alt_id: CHEBI:49550 def: "An ion of copper carrying a double positive charge." [] subset: 3_STAR synonym: "COPPER (II) ION" RELATED [PDBeChem] synonym: "copper(II) cation" RELATED [ChEBI] synonym: "copper, ion (Cu2+)" RELATED [ChemIDplus] synonym: "Cu(2+)" RELATED [UniProt] synonym: "Cu(II)" RELATED [ChEBI] synonym: "Cu2+" RELATED [ChEBI] synonym: "cupric ion" RELATED [ChEBI] xref: PDBeChem:CU is_a: CHEBI:23378 ! copper cation is_a: CHEBI:30412 ! monoatomic dication is_a: CHEBI:60240 ! divalent metal cation [Term] id: CHEBI:29067 name: carboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13626 alt_id: CHEBI:13945 alt_id: CHEBI:23026 alt_id: CHEBI:58657 def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a carboxylate" RELATED [UniProt] synonym: "carboxylic acid anions" RELATED [ChEBI] synonym: "carboxylic anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:29101 name: sodium(1+) namespace: chebi_ontology alt_id: CHEBI:26717 alt_id: CHEBI:49766 alt_id: CHEBI:9175 def: "A monoatomic monocation obtained from sodium." [] subset: 3_STAR synonym: "Na(+)" RELATED [IUPAC, UniProt] synonym: "Na+" RELATED [KEGG_COMPOUND] synonym: "SODIUM ION" RELATED [PDBeChem] xref: KEGG:C01330 xref: PDBeChem:NA is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37246 ! elemental sodium is_a: CHEBI:60242 ! monovalent inorganic cation relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:29103 name: potassium(1+) namespace: chebi_ontology alt_id: CHEBI:26219 alt_id: CHEBI:49685 alt_id: CHEBI:8345 def: "A monoatomic monocation obtained from potassium." [] subset: 3_STAR synonym: "K(+)" RELATED [IUPAC, UniProt] synonym: "K+" RELATED [KEGG_COMPOUND] synonym: "POTASSIUM ION" RELATED [PDBeChem] xref: KEGG:C00238 xref: KEGG:D08403 xref: PDBeChem:K is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37247 ! elemental potassium is_a: CHEBI:60242 ! monovalent inorganic cation relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:29192 name: hydrogenperoxide(1-) namespace: chebi_ontology subset: 3_STAR synonym: "[HO2](-)" RELATED [ChEBI] synonym: "HO2(-)" RELATED [IUPAC] synonym: "HOO anion" RELATED [NIST_Chemistry_WebBook] synonym: "HOO(-)" RELATED [ChEBI] synonym: "hydrogenperoxide(1-)" EXACT [IUPAC] is_a: CHEBI:33693 ! oxygen hydride relationship: is_conjugate_base_of CHEBI:16240 ! hydrogen peroxide [Term] id: CHEBI:29214 name: sulfonic acid namespace: chebi_ontology subset: 3_STAR synonym: "[SHO2(OH)]" RELATED [IUPAC] synonym: "acide sulfonique" RELATED [ChEBI] synonym: "HSHO3" RELATED [IUPAC] synonym: "Sulfonsaeure" RELATED [ChEBI] synonym: "sulphonic acid" RELATED [ChEBI] is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:33543 ! sulfonate relationship: is_tautomer_of CHEBI:48854 ! sulfurous acid [Term] id: CHEBI:29256 name: thiol namespace: chebi_ontology alt_id: CHEBI:13443 alt_id: CHEBI:13696 alt_id: CHEBI:17366 alt_id: CHEBI:26969 alt_id: CHEBI:8766 alt_id: CHEBI:9556 def: "An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety." [] subset: 3_STAR synonym: "a thiol" RELATED [UniProt] synonym: "Mercaptan" RELATED [KEGG_COMPOUND] synonym: "mercaptans" RELATED [ChEBI] synonym: "Merkaptan" RELATED [ChEBI] synonym: "RSH" RELATED [IUPAC] synonym: "Thiol" EXACT [KEGG_COMPOUND] synonym: "thiols" RELATED [ChEBI] xref: KEGG:C00145 xref: Wikipedia:Thiol is_a: CHEBI:33261 ! organosulfur compound relationship: BFO:0000051 CHEBI:29917 ! has part thiol group [Term] id: CHEBI:29258 name: dihydrogenphosphite namespace: chebi_ontology def: "A monovalent inorganic anion obtained by deprotonation of phosphorous acid." [] subset: 3_STAR synonym: "[PO(OH)2] (-)" RELATED [IUPAC] synonym: "dihydrogen phosphite" RELATED [ChEBI] synonym: "H2PO3(-)" RELATED [IUPAC] is_a: CHEBI:26045 ! phosphite ion is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:29259 ! hydrogenphosphite relationship: is_conjugate_base_of CHEBI:36361 ! phosphorous acid [Term] id: CHEBI:29259 name: hydrogenphosphite namespace: chebi_ontology def: "A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid." [] subset: 3_STAR synonym: "[PO2(OH)](2-)" RELATED [IUPAC] synonym: "HPO3(2-)" RELATED [IUPAC] synonym: "hydrogen phosphite" RELATED [IUPAC] is_a: CHEBI:26045 ! phosphite ion is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_acid_of CHEBI:45064 ! phosphite(3-) relationship: is_conjugate_base_of CHEBI:29258 ! dihydrogenphosphite [Term] id: CHEBI:29277 name: dinitride(2-) namespace: chebi_ontology subset: 3_STAR synonym: "N2(2-)" RELATED [IUPAC] is_a: CHEBI:33266 ! diatomic nitrogen relationship: is_conjugate_base_of CHEBI:30103 ! diazenide [Term] id: CHEBI:29281 name: alkyl sulfate namespace: chebi_ontology alt_id: CHEBI:13810 alt_id: CHEBI:22325 alt_id: CHEBI:2583 subset: 3_STAR synonym: "alkyl sulfates" RELATED [ChEBI] is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester relationship: is_conjugate_acid_of CHEBI:83414 ! alkyl sulfate(1-) [Term] id: CHEBI:29337 name: azanide namespace: chebi_ontology subset: 3_STAR synonym: "NH2(-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-) relationship: is_conjugate_base_of CHEBI:16134 ! ammonia [Term] id: CHEBI:29340 name: hydridonitrate(2-) namespace: chebi_ontology def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." [] subset: 3_STAR synonym: "imide" RELATED [IUPAC] synonym: "NH(2-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_base_of CHEBI:29337 ! azanide [Term] id: CHEBI:29347 name: monocarboxylic acid amide namespace: chebi_ontology alt_id: CHEBI:13211 alt_id: CHEBI:22207 alt_id: CHEBI:25383 alt_id: CHEBI:6977 def: "A carboxamide derived from a monocarboxylic acid." [] subset: 3_STAR synonym: "monocarboxylic acid amides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:29369 name: peroxy group namespace: chebi_ontology subset: 3_STAR synonym: "-OO-" RELATED [IUPAC] is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:29534 name: avermectin B1a namespace: chebi_ontology subset: 3_STAR synonym: "abamectin component B1a" RELATED [ChemIDplus] synonym: "Avermectin B1a" EXACT [KEGG_COMPOUND] xref: BPDB:8 xref: KEGG:C11983 xref: MetaCyc:CPD-12963 xref: VSDB:8 is_a: CHEBI:50344 ! avermectin [Term] id: CHEBI:29537 name: avermectin B1b namespace: chebi_ontology subset: 3_STAR synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside" RELATED [IUPAC] synonym: "abamectin component B1b" RELATED [ChemIDplus] synonym: "Avermectin B1b" EXACT [KEGG_COMPOUND] xref: KEGG:C11967 xref: MetaCyc:CPD-12964 is_a: CHEBI:50344 ! avermectin [Term] id: CHEBI:2955 name: azithromycin namespace: chebi_ontology alt_id: CHEBI:46596 def: "A macrolide antibiotic useful for the treatment of bacterial infections." [] subset: 3_STAR synonym: "(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one" RELATED [ChemIDplus] xref: DrugBank:DB00207 xref: HMDB:HMDB0014352 xref: KEGG:C06838 xref: KEGG:D07486 xref: LINCS:LSM-5821 xref: Patent:BE892357 xref: Patent:US4517359 xref: PDBeChem:ZIT xref: Wikipedia:Azithromycin is_a: CHEBI:25105 ! macrolide antibiotic relationship: is_conjugate_base_of CHEBI:231550 ! azithromycin(2+) relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:29687 name: teicoplanin namespace: chebi_ontology def: "A complex mixture of related natural products isolated from the fermentation broth of a strain of Actinoplanes teichomyceticus comprising five major components (teicoplanin A2-1 through A2-5), a hydrolysis component (teicoplanin A3-1), and four minor components (teicoplanin RS-1 through RS-4). An antibiotic with a similar spectrum of activity to vancomycin, it is used to treat serious Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis." [] subset: 3_STAR synonym: "antibiotic 8327A" RELATED [ChemIDplus] xref: DrugBank:DB06149 xref: KEGG:C15820 xref: KEGG:D02142 xref: Wikipedia:Teicoplanin is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:34995 ! has part teicoplanin A2-1 relationship: BFO:0000051 CHEBI:34996 ! has part teicoplanin A2-3 relationship: BFO:0000051 CHEBI:34997 ! has part teicoplanin A2-4 relationship: BFO:0000051 CHEBI:34998 ! has part teicoplanin A2-5 relationship: BFO:0000051 CHEBI:34999 ! has part teicoplanin A3-1 relationship: BFO:0000051 CHEBI:85251 ! has part teicoplanin A2-2 relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:29688 name: telithromycin namespace: chebi_ontology alt_id: CHEBI:46029 subset: 2_STAR synonym: "(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside" RELATED [PDBeChem] synonym: "HMR 3647" RELATED [DrugCentral] synonym: "HMR-3647" RELATED [KEGG_COMPOUND] synonym: "HMR3647" RELATED [KEGG_COMPOUND] synonym: "RU 66647" RELATED [DrugCentral] synonym: "RU-66647" RELATED [KEGG_COMPOUND] synonym: "RU66647" RELATED [KEGG_COMPOUND] synonym: "TELITHROMYCIN" EXACT [PDBeChem] synonym: "Telithromycin" EXACT [KEGG_COMPOUND] xref: KEGG:C12009 xref: KEGG:D01078 xref: PDBeChem:TEL is_a: CHEBI:28963 ! amino sugar [Term] id: CHEBI:29699 name: tunicamycin namespace: chebi_ontology def: "A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety." [] subset: 3_STAR synonym: "Tunicamycin" EXACT [KEGG_COMPOUND] xref: KEGG:C12063 xref: Wikipedia:Tunicamycin is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:64228 ! has part tunicamycin A0 relationship: BFO:0000051 CHEBI:64245 ! has part tunicamycin A1 relationship: BFO:0000051 CHEBI:64246 ! has part tunicamycin A2 relationship: BFO:0000051 CHEBI:64248 ! has part tunicamycin B1 relationship: BFO:0000051 CHEBI:64250 ! has part tunicamycin B2 relationship: BFO:0000051 CHEBI:64255 ! has part tunicamycin B3 relationship: BFO:0000051 CHEBI:64256 ! has part tunicamycin C1 relationship: BFO:0000051 CHEBI:64257 ! has part tunicamycin C2 relationship: BFO:0000051 CHEBI:64271 ! has part tunicamycin D1 relationship: BFO:0000051 CHEBI:64272 ! has part tunicamycin D2 relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:64237 ! has role EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor [Term] id: CHEBI:29700 name: tylactone namespace: chebi_ontology alt_id: CHEBI:76805 def: "A 16-membererd macrolide that is the aglycone of the antibiotic 5-O-beta-D-mycaminosyltylactone." [] subset: 3_STAR synonym: "20-Deoxo-12,13-desepoxy-12,13-dehydrorosaranolide" RELATED [ChemIDplus] synonym: "20-deoxo-23-deoxytylonolide" RELATED [ChemIDplus] synonym: "20-Dsdr" RELATED [ChemIDplus] synonym: "Protylonolide" RELATED [KEGG_COMPOUND] synonym: "Tylactone" EXACT [KEGG_COMPOUND] synonym: "tylactone" EXACT [UniProt] xref: KEGG:C12000 is_a: CHEBI:23824 ! diol is_a: CHEBI:25106 ! macrolide is_a: CHEBI:51689 ! enone relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:29785 name: nitro group namespace: chebi_ontology subset: 3_STAR synonym: "-NO2" RELATED [IUPAC] is_a: CHEBI:33246 ! inorganic group is_a: CHEBI:51144 ! nitrogen group [Term] id: CHEBI:29917 name: thiol group namespace: chebi_ontology alt_id: CHEBI:26821 alt_id: CHEBI:29916 subset: 3_STAR synonym: "-SH" RELATED [IUPAC] synonym: "HS-" RELATED [IUPAC] synonym: "mercapto group" RELATED [ChEBI] synonym: "Mercaptogruppe" RELATED [ChEBI] synonym: "Merkaptogruppe" RELATED [ChEBI] synonym: "sulfhydryl group" RELATED [ChEBI] synonym: "Sulfhydrylgruppe" RELATED [ChEBI] synonym: "sulphydryl group" RELATED [ChEBI] synonym: "thiol group" EXACT [UniProt] synonym: "Thiolgruppe" RELATED [ChEBI] is_a: CHEBI:33246 ! inorganic group relationship: is_substituent_group_from CHEBI:16136 ! hydrogen sulfide [Term] id: CHEBI:29919 name: hydrosulfide namespace: chebi_ontology subset: 3_STAR synonym: "HS anion" RELATED [NIST_Chemistry_WebBook] synonym: "HS(-)" RELATED [IUPAC] synonym: "hydrogen sulfide" RELATED [UniProt] synonym: "hydrosulfide" EXACT [IUPAC] is_a: CHEBI:33535 ! sulfur hydride relationship: is_conjugate_acid_of CHEBI:15138 ! sulfide(2-) relationship: is_conjugate_base_of CHEBI:16136 ! hydrogen sulfide relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:29922 name: sulfo group namespace: chebi_ontology subset: 3_STAR synonym: "-S(O)2(OH)" RELATED [IUPAC] synonym: "SULFO GROUP" EXACT [PDBeChem] xref: PDBeChem:SFO is_a: CHEBI:33246 ! inorganic group relationship: is_substituent_group_from CHEBI:29214 ! sulfonic acid [Term] id: CHEBI:30089 name: acetate namespace: chebi_ontology alt_id: CHEBI:13704 alt_id: CHEBI:22165 alt_id: CHEBI:40480 def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." [] subset: 3_STAR synonym: "acetate" EXACT [UniProt] synonym: "ACETATE ION" RELATED [PDBeChem] synonym: "acetic acid, ion(1-)" RELATED [ChemIDplus] synonym: "Azetat" RELATED [ChEBI] synonym: "CH3-COO(-)" RELATED [IUPAC] synonym: "Ethanoat" RELATED [ChEBI] synonym: "ethanoate" RELATED [ChEBI] synonym: "MeCO2 anion" RELATED [NIST_Chemistry_WebBook] xref: DrugBank:DB03166 xref: KEGG:C00033 xref: MetaCyc:ACET xref: PDBeChem:ACT xref: Wikipedia:Acetate is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:30096 name: diazene namespace: chebi_ontology subset: 3_STAR synonym: "Diimide" RELATED [NIST_Chemistry_WebBook] synonym: "HN=NH" RELATED [IUPAC] xref: KEGG:C05360 is_a: CHEBI:35106 ! nitrogen hydride relationship: is_conjugate_acid_of CHEBI:30103 ! diazenide [Term] id: CHEBI:30103 name: diazenide namespace: chebi_ontology subset: 3_STAR synonym: "N=NH(-)" RELATED [IUPAC] is_a: CHEBI:35106 ! nitrogen hydride relationship: is_conjugate_acid_of CHEBI:29277 ! dinitride(2-) relationship: is_conjugate_base_of CHEBI:30096 ! diazene [Term] id: CHEBI:30106 name: azo group namespace: chebi_ontology subset: 3_STAR synonym: "-N=N-" RELATED [IUPAC] synonym: "azo" RELATED [IUPAC] synonym: "diazene-1,2-diyl" RELATED [IUPAC] is_a: CHEBI:33246 ! inorganic group relationship: is_substituent_group_from CHEBI:30096 ! diazene [Term] id: CHEBI:3015 name: benomyl namespace: chebi_ontology def: "A member of the class of benzimidazoles that is the methyl ester of [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops." [] subset: 3_STAR synonym: "1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat" RELATED [ChemIDplus] synonym: "1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester" RELATED [ChemIDplus] synonym: "1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol" RELATED [ChemIDplus] synonym: "Benlate" RELATED [KEGG_COMPOUND] synonym: "Benomyl" EXACT [KEGG_COMPOUND] synonym: "Methyl 1-(butylamino)carbonyl-1H-benzimidazol-2-ylcarbamate" RELATED [HMDB] synonym: "Methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate" RELATED [HMDB] synonym: "Methyl N-(1-butylcarbamoyl-2-benzimidazole)carbamate" RELATED [HMDB] xref: HMDB:HMDB0031767 xref: KEGG:C10896 xref: PPDB:66 xref: Wikipedia:Benomyl is_a: CHEBI:62733 ! aromatic amide is_a: CHEBI:87036 ! benzimidazole fungicide is_a: CHEBI:87064 ! benzimidazolylcarbamate fungicide relationship: RO:0000087 CHEBI:22153 ! has role acaricide relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:30256 name: thiocarbonyl group namespace: chebi_ontology subset: 3_STAR synonym: ">C=S" RELATED [IUPAC] is_a: CHEBI:51422 ! organodiyl group [Term] id: CHEBI:30347 name: ethylenediamine namespace: chebi_ontology def: "An alkane-alpha,omega-diamine in which the alkane is ethane." [] subset: 3_STAR synonym: "1,2-ethanediamine" RELATED [IUPAC] synonym: "en" RELATED [IUPAC] synonym: "ethylenediamine" EXACT [IUPAC] xref: HMDB:HMDB0031225 xref: KEGG:D01114 xref: MetaCyc:CPD-3682 xref: PDBeChem:EDN xref: Wikipedia:Ethylenediamine is_a: CHEBI:35411 ! alkane-alpha,omega-diamine relationship: has_parent_hydride CHEBI:42266 ! ethane relationship: RO:0000087 CHEBI:51373 ! has role GABA agonist [Term] id: CHEBI:30412 name: monoatomic dication namespace: chebi_ontology alt_id: CHEBI:23856 alt_id: CHEBI:4665 subset: 3_STAR synonym: "Divalent cation" RELATED [KEGG_COMPOUND] synonym: "divalent inorganic cations" RELATED [ChEBI] synonym: "monoatomic dications" RELATED [ChEBI] xref: KEGG:C00572 is_a: CHEBI:23906 ! monoatomic cation [Term] id: CHEBI:30488 name: sulfonium namespace: chebi_ontology subset: 3_STAR synonym: "[SH3](+)" RELATED [ChEBI] synonym: "H3S(+)" RELATED [IUPAC] synonym: "H3S+" RELATED [NIST_Chemistry_WebBook] synonym: "sulphonium" RELATED [ChEBI] is_a: CHEBI:26830 ! sulfonium compound is_a: CHEBI:33535 ! sulfur hydride is_a: CHEBI:50313 ! onium cation relationship: is_conjugate_acid_of CHEBI:16136 ! hydrogen sulfide [Term] id: CHEBI:30746 name: benzoic acid namespace: chebi_ontology alt_id: CHEBI:22722 alt_id: CHEBI:3029 alt_id: CHEBI:41051 def: "A compound comprising a benzene ring core carrying a carboxylic acid substituent." [] subset: 3_STAR synonym: "acide benzoique" RELATED [ChEBI] synonym: "Aromatic carboxylic acid" RELATED [KEGG_COMPOUND] synonym: "Benzenecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "Benzeneformic acid" RELATED [HMDB] synonym: "Benzenemethanoic acid" RELATED [HMDB] synonym: "Benzoesaeure" RELATED [ChEBI] synonym: "BENZOIC ACID" EXACT [PDBeChem] synonym: "Benzoic acid" EXACT [KEGG_COMPOUND] synonym: "Dracylic acid" RELATED [KEGG_COMPOUND] synonym: "E210" RELATED [ChEBI] synonym: "Phenylcarboxylic acid" RELATED [HMDB] synonym: "Phenylformic acid" RELATED [KEGG_COMPOUND] xref: DrugBank:DB03793 xref: HMDB:HMDB0001870 xref: KEGG:C00180 xref: KEGG:C00539 xref: KEGG:D00038 xref: KNApSAcK:C00000207 xref: LINCS:LSM-37118 xref: MetaCyc:BENZOATE xref: PDBeChem:BEZ xref: PPDB:1475 xref: Wikipedia:Benzoic_Acid xref: YMDB:YMDB02301 is_a: CHEBI:22723 ! benzoic acids relationship: is_conjugate_acid_of CHEBI:16150 ! benzoate relationship: RO:0000087 CHEBI:64996 ! has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor relationship: RO:0000087 CHEBI:65001 ! has role EC 3.1.1.3 (triacylglycerol lipase) inhibitor relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:30751 name: formic acid namespace: chebi_ontology alt_id: CHEBI:24082 alt_id: CHEBI:42460 alt_id: CHEBI:5145 def: "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." [] subset: 3_STAR synonym: "Acide formique" RELATED [ChemIDplus] synonym: "Ameisensaeure" RELATED [ChemIDplus] synonym: "aminic acid" RELATED [ChemIDplus] synonym: "bilorin" RELATED [ChemIDplus] synonym: "FORMIC ACID" EXACT [PDBeChem] synonym: "Formic acid" EXACT [KEGG_COMPOUND] synonym: "formylic acid" RELATED [ChemIDplus] synonym: "H-COOH" RELATED [IUPAC] synonym: "HCO2H" RELATED [ChEBI] synonym: "HCOOH" RELATED [NIST_Chemistry_WebBook] synonym: "hydrogen carboxylic acid" RELATED [ChemIDplus] synonym: "Methanoic acid" RELATED [KEGG_COMPOUND] synonym: "methoic acid" RELATED [ChEBI] xref: BPDB:1749 xref: DrugBank:DB01942 xref: HMDB:HMDB0000142 xref: KEGG:C00058 xref: KNApSAcK:C00001182 xref: MetaCyc:FORMATE xref: Patent:CN101481304 xref: PDBeChem:FMT xref: Wikipedia:Formic_acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:15740 ! formate relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:48356 ! has role protic solvent relationship: RO:0000087 CHEBI:74783 ! has role astringent [Term] id: CHEBI:30762 name: salicylate namespace: chebi_ontology alt_id: CHEBI:15061 alt_id: CHEBI:26595 def: "A monohydroxybenzoate that is the conjugate base of salicylic acid." [] subset: 3_STAR synonym: "2-hydroxybenzoic acid ion(1-)" RELATED [ChemIDplus] synonym: "o-hydroxybenzoate" RELATED [ChemIDplus] synonym: "sal" RELATED [IUPAC] synonym: "Salicylate" EXACT [KEGG_COMPOUND] synonym: "salicylate" EXACT [UniProt] xref: KEGG:C00805 is_a: CHEBI:25388 ! monohydroxybenzoate relationship: is_conjugate_base_of CHEBI:16914 ! salicylic acid relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:30802 name: isophthalic acid namespace: chebi_ontology def: "A benzenedicarboxylic acid that is benzene substituted by carboxy groups at position 1 and 3. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and terephthalic acids." [] subset: 3_STAR synonym: "IPA" RELATED [NIST_Chemistry_WebBook] synonym: "m-benzenedicarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "meta-benzenedicarboxylic acid" RELATED [ChEBI] xref: MetaCyc:CPD0-1267 xref: Wikipedia:Isophthalic_acid is_a: CHEBI:26094 ! benzenedicarboxylic acid relationship: is_conjugate_acid_of CHEBI:30804 ! isophthalate(1-) [Term] id: CHEBI:30803 name: isophthalate(2-) namespace: chebi_ontology subset: 3_STAR synonym: "1,3-benzenedicarboxylate" RELATED [ChEBI] synonym: "isophthalate" RELATED [IUPAC, UniProt] is_a: CHEBI:28965 ! dicarboxylic acid dianion relationship: is_conjugate_base_of CHEBI:30804 ! isophthalate(1-) [Term] id: CHEBI:30804 name: isophthalate(1-) namespace: chebi_ontology def: "A dicarboxylic acid monoanion that is the conjugate base of isophthalic acid." [] subset: 3_STAR synonym: "hydrogen isophthalate" RELATED [IUPAC] xref: MetaCyc:CPD0-1267 is_a: CHEBI:35695 ! dicarboxylic acid monoanion relationship: is_conjugate_acid_of CHEBI:30803 ! isophthalate(2-) relationship: is_conjugate_base_of CHEBI:30802 ! isophthalic acid [Term] id: CHEBI:30879 name: alcohol namespace: chebi_ontology alt_id: CHEBI:13804 alt_id: CHEBI:22288 alt_id: CHEBI:2553 def: "A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." [] subset: 3_STAR synonym: "Alcohol" EXACT [KEGG_COMPOUND] synonym: "an alcohol" RELATED [UniProt] xref: KEGG:C00069 is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:30911 name: glucitol namespace: chebi_ontology alt_id: CHEBI:15093 alt_id: CHEBI:26724 alt_id: CHEBI:26726 alt_id: CHEBI:33795 alt_id: CHEBI:33796 alt_id: CHEBI:9201 subset: 3_STAR synonym: "gulitol" RELATED [ChEBI] synonym: "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" RELATED [IUPAC] synonym: "Sorbitol" RELATED [KEGG_COMPOUND] xref: Wikipedia:Sorbitol is_a: CHEBI:24583 ! hexitol relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:30938 name: 6-aminopenicillanate namespace: chebi_ontology alt_id: CHEBI:12207 alt_id: CHEBI:20704 subset: 3_STAR xref: KEGG:C02954 is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:16705 ! 6-aminopenicillanic acid relationship: is_conjugate_base_of CHEBI:57869 ! 6-aminopenicillanic acid zwitterion [Term] id: CHEBI:31011 name: valerate namespace: chebi_ontology alt_id: CHEBI:14751 alt_id: CHEBI:25890 def: "A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals." [] subset: 3_STAR synonym: "CH3-[CH2]3-COO(-)" RELATED [IUPAC] synonym: "n-propylacetate" RELATED [ChEBI] synonym: "pentanoate" RELATED [UniProt] synonym: "pentanoic acid, ion(1-)" RELATED [ChemIDplus] is_a: CHEBI:58951 ! short-chain fatty acid anion is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:17418 ! valeric acid relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:31014 name: tetracosanoate namespace: chebi_ontology def: "A straight-chain saturated fatty acid anion that is the conjugate base of tetracosanoic acid (lignoceric acid), formed by deprotonation of the carboxy group." [] subset: 3_STAR synonym: "CH3-[CH2]22-COO(-)" RELATED [IUPAC] synonym: "Lignocerat" RELATED [ChEBI] synonym: "lignocerate" RELATED [CBN] synonym: "n-tetracosanoate" RELATED [ChEBI] synonym: "tetracosanate" RELATED [ChEBI] synonym: "Tetracosanoat" RELATED [ChEBI] synonym: "tetracosanoate" EXACT [UniProt] synonym: "tetracosoate" RELATED [ChEBI] synonym: "tetraeicosanoate" RELATED [ChEBI] xref: MetaCyc:TETRACOSANOATE is_a: CHEBI:58950 ! very long-chain fatty acid anion is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion is_a: CHEBI:78128 ! fatty acid anion 24:0 is_a: CHEBI:83955 ! 2-saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:28866 ! tetracosanoic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:31286 name: bifonazole namespace: chebi_ontology def: "A racemate comprising equimolar amounts of R- and S-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections." [] subset: 3_STAR synonym: "(+-)-1-(p,alpha-Diphenylbenzyl)imidazole" RELATED [ChemIDplus] synonym: "(+-)-bifonazole" RELATED [ChEBI] synonym: "(+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole" RELATED [DrugBank] synonym: "(RS)-bifonazole" RELATED [ChEBI] synonym: "1-((4-Biphenylyl)phenylmethyl)-1H-imidazole" RELATED [DrugBank] synonym: "1-(alpha-(4-Biphenylyl)benzyl)imidazole" RELATED [ChemIDplus] synonym: "rac-bifonazole" RELATED [ChEBI] synonym: "racemic bifonazole" RELATED [ChEBI] xref: DrugBank:DB04794 xref: HMDB:HMDB0015583 xref: KEGG:D01775 xref: Wikipedia:Bifonazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87069 ! imidazole antifungal drug relationship: BFO:0000051 CHEBI:78693 ! has part (R)-bifonazole relationship: BFO:0000051 CHEBI:78694 ! has part (S)-bifonazole [Term] id: CHEBI:31577 name: ethylenediamine derivative namespace: chebi_ontology def: "Any organic amino compound that is a derivative of ethylenediamine." [] subset: 3_STAR synonym: "ethylenediamine derivatives" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: has_functional_parent CHEBI:30347 ! ethylenediamine [Term] id: CHEBI:31927 name: nystatin A3 namespace: chebi_ontology subset: 3_STAR synonym: "nystatin A3" EXACT [KEGG_COMPOUND] xref: HMDB:HMDB0242303 xref: KEGG:C12156 is_a: CHEBI:59676 ! nystatins [Term] id: CHEBI:32066 name: Prothionamide namespace: chebi_ontology alt_id: CHEBI:93717 subset: 2_STAR synonym: "2-Propylisonicotinylthioamide" RELATED [DrugCentral] synonym: "2-Propylthioisonicotinamide" RELATED [DrugCentral] synonym: "Prothionamide" EXACT [KEGG_COMPOUND] synonym: "prothionamide" EXACT [DrugCentral] synonym: "protionamid" RELATED [DrugCentral] xref: KEGG:D01195 xref: LINCS:LSM-4210 is_a: CHEBI:26421 ! pyridines [Term] id: CHEBI:32158 name: streptomycin sulfate namespace: chebi_ontology subset: 2_STAR synonym: "Streptomycin sulfate" EXACT [KEGG_COMPOUND] xref: BPDB:2472 xref: KEGG:D01350 is_a: CHEBI:38012 ! aminoglycoside sulfate salt relationship: has_functional_parent CHEBI:17076 ! streptomycin [Term] id: CHEBI:32161 name: sulfadimethoxine namespace: chebi_ontology def: "A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position." [] subset: 3_STAR synonym: "2,4-dimethoxy-6-sulfanilamido-1,3-diazine" RELATED [ChemIDplus] synonym: "2,6-dimethoxy-4-(p-aminobenzenesulfonamido)pyrimidine" RELATED [ChemIDplus] synonym: "2,6-dimethoxy-4-sulfanilamidopyrimidine" RELATED [ChemIDplus] synonym: "4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide" RELATED [ChemIDplus] synonym: "6-sulfanilamido-2,4-dimethoxypyrimidine" RELATED [ChemIDplus] synonym: "Abcid (TN)" RELATED [KEGG_DRUG] synonym: "Agribon (TN)" RELATED [KEGG_DRUG] synonym: "N(1)-(2,6-dimethoxy-4-pyrimidinyl)sulfanilamide" RELATED [ChemIDplus] synonym: "Sulfadimethoxine" EXACT [KEGG_DRUG] synonym: "Sulfadimethoxydiazine" RELATED [ChemIDplus] synonym: "Sulphadimethoxine" RELATED [ChemIDplus] xref: DrugBank:DB06150 xref: HMDB:HMDB0015621 xref: KEGG:D01142 xref: LINCS:LSM-5790 xref: VSDB:1833 xref: Wikipedia:Sulfadimethoxine is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39447 ! pyrimidines is_a: CHEBI:48975 ! substituted aniline is_a: CHEBI:87228 ! sulfonamide antibiotic relationship: has_functional_parent CHEBI:45373 ! sulfanilamide relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:32544 name: nicotinate namespace: chebi_ontology alt_id: CHEBI:14650 alt_id: CHEBI:22851 alt_id: CHEBI:25530 def: "A pyridinemonocarboxylate that is the conjugate base of nicotinic acid, arising from deprotonation of the carboxy group; major species at pH 7.3." [] subset: 3_STAR synonym: "3-pyridinecarboxylate" RELATED [ChEBI] synonym: "nicotinate" EXACT [UniProt] xref: KEGG:C00253 xref: MetaCyc:NIACINE is_a: CHEBI:176839 ! vitamin B3 is_a: CHEBI:38181 ! pyridinemonocarboxylate relationship: is_conjugate_base_of CHEBI:15940 ! nicotinic acid relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite [Term] id: CHEBI:32588 name: potassium chloride namespace: chebi_ontology def: "A metal chloride salt with a K(+) counterion." [] subset: 3_STAR synonym: "[KCl]" RELATED [MolBase] synonym: "Kaliumchlorid" RELATED [ChEBI] synonym: "KCl" RELATED [IUPAC] synonym: "Monopotassium chloride" RELATED [DrugBank] synonym: "muriate of potash" RELATED [NIST_Chemistry_WebBook] synonym: "sylvite" RELATED [ChEBI] xref: DrugBank:DB00761 xref: KEGG:D02060 xref: MetaCyc:KCL xref: MolBase:881 xref: Wikipedia:Potassium_Chloride is_a: CHEBI:190303 ! inorganic potassium salt is_a: CHEBI:36093 ! inorganic chloride relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound relationship: RO:0000087 CHEBI:33287 ! has role fertilizer [Term] id: CHEBI:32600 name: tetracene namespace: chebi_ontology def: "An acene that consists of four ortho-fused benzene rings in a rectilinear arrangement." [] subset: 3_STAR synonym: "2,3-benzanthracene" RELATED [NIST_Chemistry_WebBook] synonym: "benz[b]anthracene" RELATED [NIST_Chemistry_WebBook] synonym: "naphthacene" RELATED [IUPAC] xref: Wikipedia:Tetracene is_a: CHEBI:35297 ! acene is_a: CHEBI:51270 ! tetracenes [Term] id: CHEBI:32845 name: serinate namespace: chebi_ontology def: "An alpha-amino-acid anion that is the conjugate base of serine." [] subset: 3_STAR synonym: "2-amino-3-hydroxypropanoate" RELATED [IUPAC] synonym: "serine anion" RELATED [JCBN] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:17822 ! serine relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite [Term] id: CHEBI:32846 name: serinium namespace: chebi_ontology def: "An alpha-amino-acid cation that is the conjugate acid of serine." [] subset: 3_STAR synonym: "1-carboxy-2-hydroxyethanaminium" RELATED [IUPAC] synonym: "serine cation" RELATED [JCBN] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:17822 ! serine relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite [Term] id: CHEBI:32862 name: L-prolinate namespace: chebi_ontology def: "An optically active form of prolinate having L-configuration." [] subset: 3_STAR synonym: "(2S)-pyrrolidine-2-carboxylate" RELATED [IUPAC] synonym: "L-proline anion" RELATED [JCBN] is_a: CHEBI:32871 ! prolinate is_a: CHEBI:59814 ! L-alpha-amino acid anion relationship: is_conjugate_base_of CHEBI:17203 ! L-proline relationship: is_enantiomer_of CHEBI:32867 ! D-prolinate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:32863 name: secondary amine namespace: chebi_ontology alt_id: CHEBI:26618 alt_id: CHEBI:9078 def: "A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "R2NH" RELATED [IUPAC] synonym: "Secondary amine" EXACT [KEGG_COMPOUND] synonym: "sekundaeres Amin" RELATED [ChEBI] xref: KEGG:C02324 is_a: CHEBI:32952 ! amine is_a: CHEBI:50995 ! secondary amino compound relationship: is_conjugate_base_of CHEBI:137419 ! secondary ammonium ion [Term] id: CHEBI:32864 name: L-prolinium namespace: chebi_ontology def: "An optically active form of prolinium having L-configuration." [] subset: 3_STAR synonym: "(2S)-2-carboxypyrrolidinium" RELATED [IUPAC] synonym: "L-proline cation" RELATED [JCBN] is_a: CHEBI:32872 ! prolinium relationship: is_conjugate_acid_of CHEBI:17203 ! L-proline relationship: is_enantiomer_of CHEBI:32868 ! D-prolinium relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:32867 name: D-prolinate namespace: chebi_ontology def: "An optically active form of prolinate having D-configuration." [] subset: 3_STAR synonym: "(2R)-pyrrolidine-2-carboxylate" RELATED [IUPAC] synonym: "D-proline anion" RELATED [JCBN] is_a: CHEBI:32871 ! prolinate relationship: is_conjugate_base_of CHEBI:16313 ! D-proline relationship: is_enantiomer_of CHEBI:32862 ! L-prolinate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:32868 name: D-prolinium namespace: chebi_ontology def: "An optically active form of prolinium having D-configuration." [] subset: 3_STAR synonym: "(2R)-2-carboxypyrrolidinium" RELATED [IUPAC] synonym: "D-proline cation" RELATED [JCBN] is_a: CHEBI:32872 ! prolinium relationship: is_conjugate_acid_of CHEBI:16313 ! D-proline relationship: is_enantiomer_of CHEBI:32864 ! L-prolinium relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:32871 name: prolinate namespace: chebi_ontology def: "An alpha-amino-acid anion that is the conjugate base of proline, arising from deprotonation of the carboxy group." [] subset: 3_STAR synonym: "pro(-)" RELATED [IUPAC] synonym: "proline anion" RELATED [JCBN] synonym: "pyrrolidine-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:26271 ! proline [Term] id: CHEBI:32872 name: prolinium namespace: chebi_ontology def: "An alpha-amino-acid cation that is the conjugate acid of proline, arising from protonation of the amino group." [] subset: 3_STAR synonym: "2-carboxypyrrolidinium" RELATED [IUPAC] synonym: "H2pro(+)" RELATED [IUPAC] synonym: "proline cation" RELATED [JCBN] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:26271 ! proline [Term] id: CHEBI:32876 name: tertiary amine namespace: chebi_ontology alt_id: CHEBI:26879 alt_id: CHEBI:9458 def: "A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "R3N" RELATED [IUPAC] synonym: "tertiaeres Amin" RELATED [ChEBI] synonym: "Tertiary amine" EXACT [KEGG_COMPOUND] xref: KEGG:C02196 is_a: CHEBI:32952 ! amine is_a: CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:32877 name: primary amine namespace: chebi_ontology alt_id: CHEBI:26263 alt_id: CHEBI:26265 alt_id: CHEBI:8407 alt_id: CHEBI:8409 def: "A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group." [] subset: 3_STAR synonym: "primaeres Amin" RELATED [ChEBI] synonym: "Primary amine" EXACT [KEGG_COMPOUND] synonym: "Primary monoamine" RELATED [KEGG_COMPOUND] synonym: "R-NH2" RELATED [IUPAC] synonym: "RCH2NH2" RELATED [KEGG_COMPOUND] xref: KEGG:C00375 xref: KEGG:C00893 xref: KEGG:C02580 is_a: CHEBI:32952 ! amine is_a: CHEBI:50994 ! primary amino compound [Term] id: CHEBI:32952 name: amine namespace: chebi_ontology alt_id: CHEBI:13814 alt_id: CHEBI:22474 alt_id: CHEBI:2641 def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [] subset: 3_STAR synonym: "Amin" RELATED [ChEBI] synonym: "Amine" EXACT [KEGG_COMPOUND] synonym: "Substituted amine" RELATED [KEGG_COMPOUND] xref: KEGG:C00706 is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:32955 name: epoxide namespace: chebi_ontology alt_id: CHEBI:13828 alt_id: CHEBI:23930 alt_id: CHEBI:4812 def: "Any cyclic ether in which the oxygen atom forms part of a 3-membered ring." [] subset: 3_STAR synonym: "Alkene oxide" RELATED [KEGG_COMPOUND] synonym: "an epoxide" RELATED [UniProt] synonym: "Epoxide" EXACT [KEGG_COMPOUND] synonym: "epoxides" RELATED [ChEBI] synonym: "Olefin oxide" RELATED [KEGG_COMPOUND] xref: KEGG:C00722 xref: Wikipedia:Epoxide is_a: CHEBI:37407 ! cyclic ether relationship: has_parent_hydride CHEBI:27561 ! oxirane [Term] id: CHEBI:32964 name: ornithinate namespace: chebi_ontology alt_id: CHEBI:11448 alt_id: CHEBI:19370 subset: 3_STAR synonym: "ornithine anion" RELATED [JCBN] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: has_functional_parent CHEBI:31011 ! valerate relationship: is_conjugate_base_of CHEBI:18257 ! ornithine [Term] id: CHEBI:32988 name: amide namespace: chebi_ontology alt_id: CHEBI:22473 alt_id: CHEBI:2633 def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "Amide" EXACT [KEGG_COMPOUND] xref: KEGG:C00241 is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:33173 name: benzimidazolide namespace: chebi_ontology subset: 3_STAR synonym: "bim" RELATED [IUPAC] synonym: "bzim" RELATED [IUPAC] is_a: CHEBI:50335 ! organic nitrogen anion relationship: is_conjugate_base_of CHEBI:41275 ! 1H-benzimidazole [Term] id: CHEBI:33229 name: vitamin (role) namespace: chebi_ontology alt_id: CHEBI:10004 alt_id: CHEBI:27305 def: "A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term \"vitamines\" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines." [] subset: 3_STAR synonym: "vitamin" RELATED [ChEBI] synonym: "vitamina" RELATED [ChEBI] synonym: "vitaminas" RELATED [ChEBI] synonym: "vitamine" RELATED [ChEBI] synonym: "vitamines" RELATED [ChEBI] synonym: "vitamins" RELATED [ChEBI] synonym: "vitaminum" RELATED [ChEBI] xref: Wikipedia:Vitamin is_a: CHEBI:27027 ! micronutrient is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:33231 name: antitubercular agent namespace: chebi_ontology def: "A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis." [] subset: 3_STAR synonym: "antitubercular" RELATED [ChEBI] synonym: "antitubercular agents" RELATED [ChEBI] synonym: "antitubercular drug" RELATED [ChEBI] synonym: "antitubercular drugs" RELATED [ChEBI] synonym: "tuberculostatic agent" RELATED [ChEBI] is_a: CHEBI:64912 ! antimycobacterial drug [Term] id: CHEBI:33232 name: application namespace: chebi_ontology def: "Intended use of the molecular entity or part thereof by humans." [] subset: 3_STAR is_a: CHEBI:50906 ! role [Term] id: CHEBI:33233 name: fundamental particle namespace: chebi_ontology def: "A particle not known to have substructure." [] subset: 3_STAR synonym: "elementary particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:33238 name: monoatomic entity namespace: chebi_ontology def: "A monoatomic entity is a molecular entity consisting of a single atom." [] subset: 3_STAR synonym: "atomic entity" RELATED [ChEBI] synonym: "monoatomic entities" RELATED [ChEBI] is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33240 name: coordination entity namespace: chebi_ontology def: "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." [] subset: 3_STAR synonym: "coordination compounds" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33241 name: oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_functional_parent CHEBI:24833 ! oxoacid [Term] id: CHEBI:33242 name: inorganic hydride namespace: chebi_ontology subset: 3_STAR synonym: "inorganic hydrides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:33245 name: organic fundamental parent namespace: chebi_ontology def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." [] subset: 3_STAR synonym: "organic fundamental parents" RELATED [ChEBI] synonym: "organic parent hydrides" RELATED [ChEBI] is_a: CHEBI:37175 ! organic hydride is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33246 name: inorganic group namespace: chebi_ontology def: "Any substituent group which does not contain carbon." [] subset: 3_STAR synonym: "inorganic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:33247 name: organic group namespace: chebi_ontology def: "Any substituent group or skeleton containing carbon." [] subset: 3_STAR synonym: "organic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group relationship: is_conjugate_acid_of CHEBI:64775 ! organic anionic group relationship: is_conjugate_base_of CHEBI:64769 ! organic cationic group [Term] id: CHEBI:33248 name: hydrocarbyl group namespace: chebi_ontology def: "A univalent group formed by removing a hydrogen atom from a hydrocarbon." [] subset: 3_STAR synonym: "groupe hydrocarbyle" RELATED [IUPAC] synonym: "grupo hidrocarbilo" RELATED [IUPAC] synonym: "grupos hidrocarbilo" RELATED [IUPAC] synonym: "hydrocarbyl group" EXACT [IUPAC] is_a: CHEBI:33249 ! organyl group relationship: is_substituent_group_from CHEBI:24632 ! hydrocarbon [Term] id: CHEBI:33249 name: organyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." [] subset: 3_STAR synonym: "groupe organyle" RELATED [IUPAC] synonym: "grupo organilo" RELATED [IUPAC] synonym: "grupos organilo" RELATED [IUPAC] is_a: CHEBI:51447 ! organic univalent group [Term] id: CHEBI:33250 name: atom namespace: chebi_ontology alt_id: CHEBI:22671 alt_id: CHEBI:23907 def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." [] subset: 3_STAR synonym: "atome" RELATED [IUPAC] synonym: "atomo" RELATED [IUPAC] synonym: "atoms" RELATED [ChEBI] synonym: "atomus" RELATED [ChEBI] synonym: "element" RELATED [ChEBI] synonym: "elements" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity relationship: BFO:0000051 CHEBI:10545 ! has part electron relationship: BFO:0000051 CHEBI:33252 ! has part atomic nucleus [Term] id: CHEBI:33252 name: atomic nucleus namespace: chebi_ontology def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." [] subset: 3_STAR synonym: "Atomkern" RELATED [ChEBI] synonym: "Kern" RELATED [ChEBI] synonym: "noyau" RELATED [IUPAC] synonym: "noyau atomique" RELATED [ChEBI] synonym: "nuclei" RELATED [ChEBI] synonym: "nucleo" RELATED [IUPAC] synonym: "nucleo atomico" RELATED [ChEBI] synonym: "nucleus atomi" RELATED [ChEBI] is_a: CHEBI:36347 ! nuclear particle relationship: BFO:0000051 CHEBI:33253 ! has part nucleon [Term] id: CHEBI:33253 name: nucleon namespace: chebi_ontology def: "Heavy nuclear particle: proton or neutron." [] subset: 3_STAR synonym: "nucleon" EXACT [IUPAC] synonym: "nucleons" RELATED [ChEBI] synonym: "Nukleon" RELATED [ChEBI] synonym: "Nukleonen" RELATED [ChEBI] is_a: CHEBI:36339 ! baryon is_a: CHEBI:36347 ! nuclear particle [Term] id: CHEBI:33256 name: primary amide namespace: chebi_ontology def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] subset: 3_STAR synonym: "primary amide" EXACT [IUPAC] is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33257 name: secondary amide namespace: chebi_ontology def: "A derivative of two oxoacids RkE(=O)l(OH)m (l =/= 0) in which two acyl groups are attached to the amino or substituted amino group." [] subset: 3_STAR is_a: CHEBI:32988 ! amide [Term] id: CHEBI:33259 name: elemental molecular entity namespace: chebi_ontology def: "A molecular entity all atoms of which have the same atomic number." [] subset: 3_STAR synonym: "homoatomic entity" RELATED [ChEBI] synonym: "homoatomic molecular entities" RELATED [ChEBI] synonym: "homoatomic molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:33261 name: organosulfur compound namespace: chebi_ontology alt_id: CHEBI:23010 alt_id: CHEBI:25714 def: "An organosulfur compound is a compound containing at least one carbon-sulfur bond." [] subset: 3_STAR synonym: "organosulfur compound" EXACT [ChEBI] synonym: "organosulfur compounds" RELATED [ChEBI] xref: Wikipedia:Organosulfur_compounds is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:33266 name: diatomic nitrogen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33267 ! elemental nitrogen [Term] id: CHEBI:33267 name: elemental nitrogen namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33465 ! elemental pnictogen is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:33273 name: polyatomic anion namespace: chebi_ontology def: "An anion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic anions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion is_a: CHEBI:36358 ! polyatomic ion [Term] id: CHEBI:33280 name: molecular messenger namespace: chebi_ontology subset: 3_STAR synonym: "chemical messenger" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33281 name: antimicrobial agent namespace: chebi_ontology alt_id: CHEBI:22582 def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." [] subset: 3_STAR synonym: "antibiotic" RELATED [ChEBI] synonym: "antibiotics" RELATED [ChEBI] synonym: "Antibiotika" RELATED [ChEBI] synonym: "Antibiotikum" RELATED [ChEBI] synonym: "antibiotique" RELATED [IUPAC] synonym: "antimicrobial" RELATED [ChEBI] synonym: "antimicrobial agents" RELATED [ChEBI] synonym: "antimicrobials" RELATED [ChEBI] synonym: "microbicide" RELATED [ChEBI] synonym: "microbicides" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:33282 name: antibacterial agent namespace: chebi_ontology def: "A substance (or active part thereof) that kills or slows the growth of bacteria." [] subset: 3_STAR synonym: "antibacterial agents" RELATED [ChEBI] synonym: "antibacterials" RELATED [ChEBI] synonym: "bactericide" RELATED [ChEBI] synonym: "bactericides" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:33284 name: nutrient namespace: chebi_ontology def: "A nutrient is a food component that an organism uses to survive and grow." [] subset: 3_STAR synonym: "nutrients" RELATED [ChEBI] is_a: CHEBI:78295 ! food component [Term] id: CHEBI:33285 name: heteroorganic entity namespace: chebi_ontology def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." [] subset: 3_STAR synonym: "heteroorganic entities" RELATED [ChEBI] synonym: "organoelement compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33286 name: agrochemical namespace: chebi_ontology def: "An agrochemical is a substance that is used in agriculture or horticulture." [] subset: 3_STAR synonym: "agrichemical" RELATED [ChEBI] synonym: "agrichemicals" RELATED [ChEBI] synonym: "agricultural chemicals" RELATED [ChEBI] synonym: "agrochemicals" RELATED [ChEBI] xref: Wikipedia:Agrochemical is_a: CHEBI:33232 ! application [Term] id: CHEBI:33287 name: fertilizer namespace: chebi_ontology def: "A fertilizer is any substance that is added to soil or water to assist the growth of plants." [] subset: 3_STAR synonym: "fertiliser" RELATED [ChEBI] synonym: "fertilizers" RELATED [ChEBI] is_a: CHEBI:33286 ! agrochemical [Term] id: CHEBI:33292 name: fuel namespace: chebi_ontology def: "An energy-rich substance that can be transformed with release of usable energy." [] subset: 3_STAR is_a: CHEBI:33232 ! application [Term] id: CHEBI:33296 name: alkali metal molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of an alkali metal." [] subset: 3_STAR synonym: "alkali metal molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: BFO:0000051 CHEBI:22314 ! has part alkali metal atom [Term] id: CHEBI:33300 name: pnictogen namespace: chebi_ontology def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." [] subset: 3_STAR synonym: "group 15 elements" RELATED [ChEBI] synonym: "group V elements" RELATED [ChEBI] synonym: "nitrogenoideos" RELATED [ChEBI] synonym: "nitrogenoides" RELATED [ChEBI] synonym: "pnictogene" RELATED [ChEBI] synonym: "pnictogenes" RELATED [ChEBI] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33302 name: pnictogen molecular entity namespace: chebi_ontology def: "A p-block molecular entity containing any pnictogen." [] subset: 3_STAR synonym: "pnictogen molecular entities" RELATED [ChEBI] synonym: "pnictogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: BFO:0000051 CHEBI:33300 ! has part pnictogen [Term] id: CHEBI:33303 name: chalcogen namespace: chebi_ontology def: "Any p-block element belonging to the group 16 family of the periodic table." [] subset: 3_STAR synonym: "anfigeno" RELATED [ChEBI] synonym: "anfigenos" RELATED [ChEBI] synonym: "calcogeno" RELATED [ChEBI] synonym: "calcogenos" RELATED [ChEBI] synonym: "chalcogene" RELATED [ChEBI] synonym: "chalcogenes" RELATED [ChEBI] synonym: "Chalkogen" RELATED [ChEBI] synonym: "Chalkogene" RELATED [ChEBI] synonym: "group 16 elements" RELATED [ChEBI] synonym: "group VI elements" RELATED [ChEBI] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33304 name: chalcogen molecular entity namespace: chebi_ontology def: "Any p-block molecular entity containing a chalcogen." [] subset: 3_STAR synonym: "chalcogen compounds" RELATED [ChEBI] synonym: "chalcogen molecular entities" RELATED [ChEBI] synonym: "chalcogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: BFO:0000051 CHEBI:33303 ! has part chalcogen [Term] id: CHEBI:33306 name: carbon group element atom namespace: chebi_ontology subset: 3_STAR synonym: "carbon group element" RELATED [ChEBI] synonym: "carbon group elements" RELATED [ChEBI] synonym: "carbonoides" RELATED [ChEBI] synonym: "cristallogene" RELATED [ChEBI] synonym: "cristallogenes" RELATED [ChEBI] synonym: "group IV elements" RELATED [ChEBI] is_a: CHEBI:33560 ! p-block element atom [Term] id: CHEBI:33308 name: carboxylic ester namespace: chebi_ontology alt_id: CHEBI:13204 alt_id: CHEBI:23028 alt_id: CHEBI:3408 def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." [] subset: 3_STAR synonym: "a carboxylic ester" RELATED [UniProt] synonym: "carboxylic acid esters" RELATED [ChEBI] synonym: "Carboxylic ester" EXACT [KEGG_COMPOUND] xref: KEGG:C02391 xref: Wikipedia:Ester is_a: CHEBI:35701 ! ester is_a: CHEBI:36586 ! carbonyl compound [Term] id: CHEBI:33318 name: main group element atom namespace: chebi_ontology def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." [] subset: 3_STAR synonym: "Hauptgruppenelement" RELATED [ChEBI] synonym: "Hauptgruppenelemente" RELATED [ChEBI] synonym: "main group element" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33338 name: aryl group namespace: chebi_ontology def: "A group derived from an arene by removal of a hydrogen atom from a ring carbon atom." [] subset: 3_STAR synonym: "Arylgruppe" RELATED [ChEBI] synonym: "groupe aryle" RELATED [IUPAC] synonym: "grupos arilo" RELATED [IUPAC] is_a: CHEBI:33248 ! hydrocarbyl group relationship: is_substituent_group_from CHEBI:33658 ! arene [Term] id: CHEBI:33340 name: zinc group element atom namespace: chebi_ontology subset: 3_STAR synonym: "zinc group element" RELATED [ChEBI] synonym: "zinc group elements" RELATED [ChEBI] is_a: CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33352 name: manganese group element atom namespace: chebi_ontology subset: 3_STAR synonym: "manganese group element" RELATED [ChEBI] synonym: "manganese group elements" RELATED [ChEBI] is_a: CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33366 name: copper group element atom namespace: chebi_ontology subset: 3_STAR synonym: "coinage metals" RELATED [ChEBI] synonym: "copper group element" RELATED [ChEBI] synonym: "copper group elements" RELATED [ChEBI] is_a: CHEBI:33561 ! d-block element atom [Term] id: CHEBI:33402 name: sulfur oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "oxoacids of sulfur" RELATED [ChEBI] synonym: "sulfur oxoacids" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33484 ! chalcogen oxoacid [Term] id: CHEBI:33405 name: hydracid namespace: chebi_ontology def: "A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] subset: 3_STAR synonym: "hydracids" RELATED [ChEBI] is_a: CHEBI:33608 ! hydrogen molecular entity relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid [Term] id: CHEBI:33408 name: pnictogen oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen oxoacids" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:33302 ! pnictogen molecular entity relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid [Term] id: CHEBI:33424 name: sulfur oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfur oxoacid derivative" EXACT [ChEBI] synonym: "sulfur oxoacid derivatives" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33241 ! oxoacid derivative [Term] id: CHEBI:33429 name: monoatomic monoanion namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic monoanions" RELATED [ChEBI] is_a: CHEBI:23905 ! monoatomic anion is_a: CHEBI:36830 ! monoanion [Term] id: CHEBI:33431 name: elemental chlorine namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:33434 ! elemental halogen [Term] id: CHEBI:33432 name: monoatomic chlorine namespace: chebi_ontology subset: 3_STAR synonym: "atomic chlorine" RELATED [ChEBI] is_a: CHEBI:33431 ! elemental chlorine is_a: CHEBI:33433 ! monoatomic halogen [Term] id: CHEBI:33433 name: monoatomic halogen namespace: chebi_ontology subset: 3_STAR synonym: "monoatomic halogens" RELATED [ChEBI] is_a: CHEBI:33238 ! monoatomic entity [Term] id: CHEBI:33434 name: elemental halogen namespace: chebi_ontology subset: 3_STAR synonym: "elemental halogen" EXACT [ChEBI] synonym: "elemental halogens" RELATED [ChEBI] is_a: CHEBI:33259 ! elemental molecular entity [Term] id: CHEBI:33447 name: phospho sugar namespace: chebi_ontology alt_id: CHEBI:15132 alt_id: CHEBI:25406 alt_id: CHEBI:26086 alt_id: CHEBI:9320 def: "Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid." [] subset: 3_STAR synonym: "monosaccharide phosphates" RELATED [ChEBI] synonym: "phospho sugar" EXACT [ChEBI] synonym: "phospho sugars" RELATED [ChEBI] synonym: "phosphorylated sugar" RELATED [ChEBI] synonym: "phosphorylated sugars" RELATED [ChEBI] synonym: "phosphosugar" RELATED [ChEBI] synonym: "phosphosugars" RELATED [ChEBI] xref: KEGG:C00934 is_a: CHEBI:26816 ! carbohydrate phosphate is_a: CHEBI:63367 ! monosaccharide derivative [Term] id: CHEBI:33457 name: phosphorus oxoacid namespace: chebi_ontology def: "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." [] subset: 3_STAR synonym: "oxoacids of phosphorus" RELATED [ChEBI] synonym: "Oxosaeure des Phosphors" RELATED [ChEBI] synonym: "phosphorus oxoacid" EXACT [ChEBI] synonym: "phosphorus oxoacids" RELATED [ChEBI] is_a: CHEBI:33408 ! pnictogen oxoacid is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:33459 name: pnictogen oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen oxoanion" EXACT [ChEBI] synonym: "pnictogen oxoanions" RELATED [ChEBI] is_a: CHEBI:33302 ! pnictogen molecular entity is_a: CHEBI:35406 ! oxoanion [Term] id: CHEBI:33461 name: phosphorus oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "oxoanions of phosphorus" RELATED [ChEBI] synonym: "phosphorus oxoanion" EXACT [ChEBI] synonym: "phosphorus oxoanions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion is_a: CHEBI:26082 ! phosphorus molecular entity is_a: CHEBI:33459 ! pnictogen oxoanion [Term] id: CHEBI:33462 name: phosphonate(1-) namespace: chebi_ontology def: "A monovalent inorganic anion obtained by deprotonation of one of the two OH groups in phosphonic acid." [] subset: 3_STAR synonym: "[PHO2(OH)](-)" RELATED [IUPAC] synonym: "hydrogenphosphonate" RELATED [IUPAC] xref: PDBeChem:78T is_a: CHEBI:33461 ! phosphorus oxoanion is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:16215 ! phosphonate(2-) relationship: is_conjugate_base_of CHEBI:44976 ! phosphonic acid [Term] id: CHEBI:33465 name: elemental pnictogen namespace: chebi_ontology subset: 3_STAR synonym: "elemental pnictogen" EXACT [ChEBI] synonym: "elemental pnictogens" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33259 ! elemental molecular entity is_a: CHEBI:33302 ! pnictogen molecular entity [Term] id: CHEBI:33482 name: sulfur oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "oxoanions of sulfur" RELATED [ChEBI] synonym: "sulfur oxoanion" EXACT [ChEBI] synonym: "sulfur oxoanions" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33485 ! chalcogen oxoanion [Term] id: CHEBI:33484 name: chalcogen oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoacid" EXACT [ChEBI] synonym: "chalcogen oxoacids" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid [Term] id: CHEBI:33485 name: chalcogen oxoanion namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen oxoanion" EXACT [ChEBI] synonym: "chalcogen oxoanions" RELATED [ChEBI] is_a: CHEBI:35406 ! oxoanion [Term] id: CHEBI:33497 name: transition element molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of a transition element." [] subset: 3_STAR synonym: "transition element molecular entities" RELATED [ChEBI] synonym: "transition metal molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: BFO:0000051 CHEBI:27081 ! has part transition element atom [Term] id: CHEBI:33504 name: alkali metal cation namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal cations" RELATED [ChEBI] is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33515 name: transition element cation namespace: chebi_ontology subset: 3_STAR synonym: "transition element cations" RELATED [ChEBI] synonym: "transition metal cation" RELATED [ChEBI] is_a: CHEBI:25213 ! metal cation [Term] id: CHEBI:33521 name: metal atom namespace: chebi_ontology alt_id: CHEBI:25217 alt_id: CHEBI:6788 def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." [] subset: 3_STAR synonym: "elemental metal" RELATED [ChEBI] synonym: "elemental metals" RELATED [ChEBI] synonym: "metal element" RELATED [ChEBI] synonym: "metal elements" RELATED [ChEBI] synonym: "metals" RELATED [ChEBI] xref: KEGG:C00050 xref: Wikipedia:Metal is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33535 name: sulfur hydride namespace: chebi_ontology subset: 3_STAR synonym: "hydrides of sulfur" RELATED [ChEBI] synonym: "sulfur hydride" EXACT [ChEBI] synonym: "sulfur hydrides" RELATED [ChEBI] synonym: "sulphur hydrides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:36902 ! chalcogen hydride [Term] id: CHEBI:33543 name: sulfonate namespace: chebi_ontology def: "The sulfur oxoanion formed by deprotonation of sulfonic acid." [] subset: 3_STAR synonym: "[SHO3](-)" RELATED [IUPAC] synonym: "SHO3(-)" RELATED [IUPAC] synonym: "sulfonates" RELATED [ChEBI] is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_base_of CHEBI:29214 ! sulfonic acid [Term] id: CHEBI:33551 name: organosulfonic acid namespace: chebi_ontology def: "An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon." [] subset: 3_STAR synonym: "organosulfonic acids" RELATED [ChEBI] synonym: "sulfonic acids" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:33552 ! sulfonic acid derivative is_a: CHEBI:64709 ! organic acid relationship: BFO:0000051 CHEBI:29922 ! has part sulfo group relationship: BFO:0000051 CHEBI:33249 ! has part organyl group relationship: is_conjugate_acid_of CHEBI:33554 ! organosulfonate oxoanion [Term] id: CHEBI:33552 name: sulfonic acid derivative namespace: chebi_ontology subset: 3_STAR synonym: "derivatives of sulfonic acid" RELATED [ChEBI] synonym: "sulfonic acid derivative" EXACT [ChEBI] synonym: "sulfonic acid derivatives" RELATED [ChEBI] is_a: CHEBI:33424 ! sulfur oxoacid derivative relationship: has_functional_parent CHEBI:29214 ! sulfonic acid [Term] id: CHEBI:33554 name: organosulfonate oxoanion namespace: chebi_ontology def: "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." [] subset: 3_STAR synonym: "organosulfonate" RELATED [ChEBI] synonym: "organosulfonate oxoanions" RELATED [ChEBI] synonym: "organosulfonates" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: has_functional_parent CHEBI:33543 ! sulfonate relationship: is_conjugate_base_of CHEBI:33551 ! organosulfonic acid [Term] id: CHEBI:33555 name: arenesulfonic acid namespace: chebi_ontology def: "Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an aryl group." [] subset: 3_STAR synonym: "arenesulfonic acids" RELATED [ChEBI] synonym: "arylsulfonic acid" RELATED [ChEBI] synonym: "arylsulfonic acids" RELATED [ChEBI] is_a: CHEBI:33551 ! organosulfonic acid relationship: BFO:0000051 CHEBI:33338 ! has part aryl group relationship: is_conjugate_acid_of CHEBI:22713 ! arenesulfonate oxoanion [Term] id: CHEBI:33558 name: alpha-amino-acid anion namespace: chebi_ontology def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino acid anion" RELATED [ChEBI] synonym: "alpha-amino acid anions" RELATED [ChEBI] synonym: "alpha-amino-acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33559 name: s-block element atom namespace: chebi_ontology subset: 3_STAR synonym: "s-block element" RELATED [ChEBI] synonym: "s-block elements" RELATED [ChEBI] is_a: CHEBI:33250 ! atom [Term] id: CHEBI:33560 name: p-block element atom namespace: chebi_ontology def: "Any main group element atom belonging to the p-block of the periodic table." [] subset: 3_STAR synonym: "p-block element" RELATED [ChEBI] synonym: "p-block elements" RELATED [ChEBI] is_a: CHEBI:33318 ! main group element atom [Term] id: CHEBI:33561 name: d-block element atom namespace: chebi_ontology subset: 3_STAR synonym: "d-block element" RELATED [ChEBI] synonym: "d-block elements" RELATED [ChEBI] is_a: CHEBI:27081 ! transition element atom [Term] id: CHEBI:33570 name: benzenediols namespace: chebi_ontology alt_id: CHEBI:22705 alt_id: CHEBI:22711 subset: 3_STAR is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:33572 name: resorcinols namespace: chebi_ontology def: "Any benzenediol in which the two hydroxy groups are meta to one another." [] subset: 3_STAR is_a: CHEBI:33570 ! benzenediols [Term] id: CHEBI:33575 name: carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13428 alt_id: CHEBI:13627 alt_id: CHEBI:23027 def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." [] subset: 3_STAR synonym: "acide carboxylique" RELATED [IUPAC] synonym: "acides carboxyliques" RELATED [IUPAC] synonym: "acido carboxilico" RELATED [IUPAC] synonym: "acidos carboxilicos" RELATED [IUPAC] synonym: "Carbonsaeure" RELATED [ChEBI] synonym: "Carbonsaeuren" RELATED [ChEBI] synonym: "Karbonsaeure" RELATED [ChEBI] synonym: "RC(=O)OH" RELATED [IUPAC] xref: Wikipedia:Carboxylic_acid is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36586 ! carbonyl compound is_a: CHEBI:64709 ! organic acid relationship: BFO:0000051 CHEBI:46883 ! has part carboxy group relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:33579 name: main group molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." [] subset: 3_STAR synonym: "main group compounds" RELATED [ChEBI] synonym: "main group molecular entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: BFO:0000051 CHEBI:33318 ! has part main group element atom [Term] id: CHEBI:33582 name: carbon group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "carbon group molecular entities" RELATED [ChEBI] synonym: "carbon group molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: BFO:0000051 CHEBI:33306 ! has part carbon group element atom [Term] id: CHEBI:33595 name: cyclic compound namespace: chebi_ontology def: "Any molecule that consists of a series of atoms joined together to form a ring." [] subset: 3_STAR synonym: "cyclic compounds" RELATED [ChEBI] xref: Wikipedia:Cyclic_compound is_a: CHEBI:25367 ! molecule [Term] id: CHEBI:33597 name: homocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of the same element only." [] subset: 3_STAR synonym: "isocyclic compounds" RELATED [IUPAC] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33598 name: carbocyclic compound namespace: chebi_ontology def: "A homocyclic compound in which all of the ring members are carbon atoms." [] subset: 3_STAR synonym: "carbocycle" RELATED [ChEBI] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33599 name: spiro compound namespace: chebi_ontology def: "A compound having one atom as the only common member of two rings." [] subset: 3_STAR synonym: "spiro-fused compounds" RELATED [IUPAC] synonym: "spirocycle" RELATED [ChEBI] synonym: "spirocycles" RELATED [ChEBI] synonym: "spirocyclic compound" RELATED [ChEBI] synonym: "spirocyclic compounds" RELATED [ChEBI] synonym: "spirofused compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound [Term] id: CHEBI:33608 name: hydrogen molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "hydrogen compounds" RELATED [ChEBI] synonym: "hydrogen molecular entities" RELATED [ChEBI] is_a: CHEBI:33674 ! s-block molecular entity relationship: BFO:0000051 CHEBI:49637 ! has part hydrogen atom [Term] id: CHEBI:33635 name: polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33636 name: bicyclic compound namespace: chebi_ontology def: "A molecule that features two fused rings." [] subset: 3_STAR synonym: "bicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33637 name: ortho-fused compound namespace: chebi_ontology def: "A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have n common faces and 2n common atoms." [] subset: 3_STAR synonym: "ortho-fused compounds" RELATED [ChEBI] is_a: CHEBI:35293 ! fused compound [Term] id: CHEBI:33641 name: olefin namespace: chebi_ontology def: "Acyclic and cyclic hydrocarbons having one or more carbon-carbon double bonds, apart from the formal ones in aromatic compounds. The class olefins subsumes alkenes and cycloalkenes and the corresponding polyenes." [] subset: 3_STAR synonym: "olefins" RELATED [ChEBI] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:33653 name: aliphatic compound namespace: chebi_ontology def: "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." [] subset: 3_STAR is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33655 name: aromatic compound namespace: chebi_ontology def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." [] subset: 3_STAR synonym: "aromatics" RELATED [ChEBI] synonym: "aromatische Verbindungen" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33658 name: arene namespace: chebi_ontology def: "Any monocyclic or polycyclic aromatic hydrocarbon." [] subset: 3_STAR synonym: "aromatic hydrocarbons" RELATED [IUPAC] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33663 ! cyclic hydrocarbon [Term] id: CHEBI:33659 name: organic aromatic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic aromatic compounds" RELATED [ChEBI] is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:33661 name: monocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "monocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:33662 name: annulene namespace: chebi_ontology def: "A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms." [] subset: 3_STAR is_a: CHEBI:33664 ! monocyclic hydrocarbon [Term] id: CHEBI:33663 name: cyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "cyclic hydrocarbon" EXACT [ChEBI] synonym: "cyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:33598 ! carbocyclic compound [Term] id: CHEBI:33664 name: monocyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "monocyclic hydrocarbon" EXACT [ChEBI] synonym: "monocyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:33663 ! cyclic hydrocarbon [Term] id: CHEBI:33666 name: polycyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33663 ! cyclic hydrocarbon is_a: CHEBI:35294 ! carbopolycyclic compound [Term] id: CHEBI:33670 name: heteromonocyclic compound namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33661 ! monocyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33671 name: heteropolycyclic compound namespace: chebi_ontology def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." [] subset: 3_STAR synonym: "polyheterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33672 name: heterobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." [] subset: 3_STAR is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:5686 ! heterocyclic compound [Term] id: CHEBI:33673 name: zinc group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc group molecular entities" RELATED [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: BFO:0000051 CHEBI:33340 ! has part zinc group element atom [Term] id: CHEBI:33674 name: s-block molecular entity namespace: chebi_ontology def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." [] subset: 3_STAR synonym: "s-block compounds" RELATED [ChEBI] synonym: "s-block molecular entities" RELATED [ChEBI] synonym: "s-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: BFO:0000051 CHEBI:33559 ! has part s-block element atom [Term] id: CHEBI:33675 name: p-block molecular entity namespace: chebi_ontology def: "A main group molecular entity that contains one or more atoms of a p-block element." [] subset: 3_STAR synonym: "p-block compounds" RELATED [ChEBI] synonym: "p-block molecular entities" RELATED [ChEBI] synonym: "p-block molecular entitiy" RELATED [ChEBI] is_a: CHEBI:33579 ! main group molecular entity relationship: BFO:0000051 CHEBI:33560 ! has part p-block element atom [Term] id: CHEBI:33676 name: d-block molecular entity namespace: chebi_ontology def: "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." [] subset: 3_STAR synonym: "d-block compounds" RELATED [ChEBI] synonym: "d-block molecular entities" RELATED [ChEBI] synonym: "d-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33497 ! transition element molecular entity relationship: BFO:0000051 CHEBI:33561 ! has part d-block element atom [Term] id: CHEBI:33692 name: hydrides namespace: chebi_ontology def: "Hydrides are chemical compounds of hydrogen with other chemical elements." [] subset: 3_STAR is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:33693 name: oxygen hydride namespace: chebi_ontology subset: 3_STAR synonym: "hydrides of oxygen" RELATED [ChEBI] synonym: "oxygen hydride" EXACT [ChEBI] synonym: "oxygen hydrides" RELATED [ChEBI] is_a: CHEBI:36902 ! chalcogen hydride [Term] id: CHEBI:33694 name: biomacromolecule namespace: chebi_ontology def: "A macromolecule formed by a living organism." [] subset: 3_STAR synonym: "biomacromolecules" RELATED [ChEBI] synonym: "Biopolymere" RELATED [ChEBI] synonym: "biopolymers" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33695 name: information biomacromolecule namespace: chebi_ontology subset: 3_STAR synonym: "genetically encoded biomacromolecules" RELATED [ChEBI] synonym: "genetically encoded biopolymers" RELATED [ChEBI] synonym: "information biomacromolecules" RELATED [ChEBI] synonym: "information biopolymers" RELATED [ChEBI] synonym: "information macromolecule" RELATED [ChEBI] synonym: "information macromolecules" RELATED [ChEBI] is_a: CHEBI:33694 ! biomacromolecule [Term] id: CHEBI:33696 name: nucleic acid namespace: chebi_ontology def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." [] subset: 3_STAR synonym: "acide nucleique" RELATED [ChEBI] synonym: "acides nucleiques" RELATED [ChEBI] synonym: "acido nucleico" RELATED [ChEBI] synonym: "acidos nucleicos" RELATED [ChEBI] synonym: "NA" RELATED [ChEBI] synonym: "Nukleinsaeure" RELATED [ChEBI] synonym: "Nukleinsaeuren" RELATED [ChEBI] is_a: CHEBI:15986 ! polynucleotide relationship: BFO:0000051 CHEBI:33791 ! has part canonical nucleoside residue relationship: BFO:0000051 CHEBI:50297 ! has part canonical nucleotide residue [Term] id: CHEBI:33697 name: ribonucleic acid namespace: chebi_ontology def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." [] subset: 3_STAR synonym: "pentosenucleic acids" RELATED [ChemIDplus] synonym: "ribonucleic acid" EXACT [IUPAC] synonym: "ribonucleic acids" RELATED [ChEBI] synonym: "Ribonukleinsaeure" RELATED [ChEBI] synonym: "ribose nucleic acid" RELATED [ChEBI] synonym: "RNA" RELATED [IUPAC, UniProt] synonym: "RNS" RELATED [ChEBI] synonym: "yeast nucleic acid" RELATED [ChEBI] is_a: CHEBI:33696 ! nucleic acid relationship: BFO:0000051 CHEBI:33792 ! has part canonical ribonucleoside residue relationship: BFO:0000051 CHEBI:50299 ! has part canonical ribonucleotide residue [Term] id: CHEBI:33700 name: proteinogenic amino-acid residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical amino-acid residue" RELATED [ChEBI] synonym: "canonical amino-acid residues" RELATED [ChEBI] synonym: "common amino acid residues" RELATED [ChEBI] synonym: "proteinogenic amino-acid residues" RELATED [ChEBI] synonym: "standard amino acid residues" RELATED [ChEBI] synonym: "standard amino-acid residues" RELATED [ChEBI] is_a: CHEBI:33710 ! alpha-amino-acid residue [Term] id: CHEBI:33702 name: polyatomic cation namespace: chebi_ontology def: "A cation consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic cations" RELATED [ChEBI] is_a: CHEBI:36358 ! polyatomic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:33703 name: amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "amino acid cation" RELATED [ChEBI] synonym: "amino acid cations" RELATED [ChEBI] synonym: "amino-acid cations" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:33702 ! polyatomic cation relationship: is_conjugate_acid_of CHEBI:33709 ! amino acid [Term] id: CHEBI:33704 name: alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:10208 alt_id: CHEBI:13779 alt_id: CHEBI:22442 alt_id: CHEBI:2642 def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." [] subset: 3_STAR synonym: "alpha-amino acids" RELATED [ChEBI, JCBN] synonym: "alpha-amino carboxylic acids" RELATED [IUPAC] synonym: "Amino acid" RELATED [KEGG_COMPOUND] synonym: "Amino acids" RELATED [KEGG_COMPOUND] xref: KEGG:C00045 xref: KEGG:C05167 is_a: CHEBI:33709 ! amino acid relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:33719 ! alpha-amino-acid cation relationship: is_tautomer_of CHEBI:78608 ! alpha-amino-acid zwitterion [Term] id: CHEBI:33708 name: amino-acid residue namespace: chebi_ontology def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." [] subset: 3_STAR synonym: "amino acid residue" RELATED [ChEBI] synonym: "amino acid residues" RELATED [ChEBI] synonym: "amino-acid residues" RELATED [JCBN] is_a: CHEBI:33247 ! organic group relationship: is_conjugate_acid_of CHEBI:64898 ! anionic amino-acid residue relationship: is_conjugate_base_of CHEBI:58942 ! cationic amino-acid residue relationship: is_substituent_group_from CHEBI:33709 ! amino acid [Term] id: CHEBI:33709 name: amino acid namespace: chebi_ontology alt_id: CHEBI:13815 alt_id: CHEBI:22477 def: "A carboxylic acid containing one or more amino groups." [] subset: 3_STAR synonym: "amino acids" RELATED [ChEBI] synonym: "Aminocarbonsaeure" RELATED [ChEBI] synonym: "Aminokarbonsaeure" RELATED [ChEBI] synonym: "Aminosaeure" RELATED [ChEBI] xref: Wikipedia:Amino_acid is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33703 ! amino-acid cation [Term] id: CHEBI:3371 name: capreomycin namespace: chebi_ontology subset: 2_STAR synonym: "Capreomycin" EXACT [KEGG_COMPOUND] synonym: "capreomycins" RELATED [ChEBI] xref: KEGG:C01790 xref: KEGG:D07607 is_a: CHEBI:25903 ! peptide antibiotic [Term] id: CHEBI:33710 name: alpha-amino-acid residue namespace: chebi_ontology def: "An amino-acid residue derived from an alpha-amino acid." [] subset: 3_STAR synonym: "alpha-amino-acid residues" RELATED [ChEBI] synonym: "an alpha-amino acid residue" RELATED [UniProt] is_a: CHEBI:33708 ! amino-acid residue relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33719 name: alpha-amino-acid cation namespace: chebi_ontology subset: 3_STAR synonym: "alpha-amino acid cation" RELATED [ChEBI] synonym: "alpha-amino acid cations" RELATED [ChEBI] synonym: "alpha-amino-acid cations" RELATED [ChEBI] is_a: CHEBI:33703 ! amino-acid cation relationship: is_conjugate_acid_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:33743 name: manganese group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "manganese group molecular entities" RELATED [ChEBI] synonym: "manganese group molecular entity" EXACT [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: BFO:0000051 CHEBI:33352 ! has part manganese group element atom [Term] id: CHEBI:33745 name: copper group molecular entity namespace: chebi_ontology subset: 3_STAR synonym: "copper group molecular entities" RELATED [ChEBI] synonym: "copper group molecular entity" EXACT [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: BFO:0000051 CHEBI:33366 ! has part copper group element atom [Term] id: CHEBI:33791 name: canonical nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleoside residues" RELATED [ChEBI] synonym: "common nucleoside residues" RELATED [CBN] synonym: "nucleoside residue" RELATED [CBN] synonym: "standard nucleoside residues" RELATED [ChEBI] is_a: CHEBI:50320 ! nucleoside residue [Term] id: CHEBI:33792 name: canonical ribonucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleoside residues" RELATED [ChEBI] synonym: "common ribonucleoside residue" RELATED [CBN] synonym: "common ribonucleoside residues" RELATED [CBN] synonym: "N" RELATED [CBN] synonym: "Nuc" RELATED [CBN] synonym: "standard ribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue [Term] id: CHEBI:33822 name: organic hydroxy compound namespace: chebi_ontology alt_id: CHEBI:64710 def: "An organic compound having at least one hydroxy group attached to a carbon atom." [] subset: 3_STAR synonym: "organic alcohol" RELATED [ChEBI] synonym: "organic hydroxy compounds" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33832 name: organic cyclic compound namespace: chebi_ontology def: "Any organic molecule that consists of atoms connected in the form of a ring." [] subset: 3_STAR synonym: "organic cyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:33833 name: heteroarene namespace: chebi_ontology def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." [] subset: 3_STAR synonym: "hetarenes" RELATED [IUPAC] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33836 name: benzenoid aromatic compound namespace: chebi_ontology subset: 3_STAR synonym: "benzenoid aromatic compounds" RELATED [ChEBI] synonym: "benzenoid compound" RELATED [ChEBI] is_a: CHEBI:33598 ! carbocyclic compound is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:33838 name: nucleoside namespace: chebi_ontology alt_id: CHEBI:13661 alt_id: CHEBI:25611 alt_id: CHEBI:7647 def: "An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." [] subset: 3_STAR synonym: "a nucleoside" RELATED [UniProt] synonym: "Nucleoside" EXACT [KEGG_COMPOUND] synonym: "nucleosides" RELATED [ChEBI] xref: KEGG:C00801 xref: Wikipedia:Nucleoside is_a: CHEBI:21731 ! N-glycosyl compound is_a: CHEBI:26912 ! oxolanes is_a: CHEBI:61120 ! nucleobase-containing molecular entity [Term] id: CHEBI:33839 name: macromolecule namespace: chebi_ontology def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [] subset: 3_STAR synonym: "macromolecules" RELATED [ChEBI] synonym: "polymer" RELATED [ChEBI] synonym: "polymer molecule" RELATED [IUPAC] synonym: "polymers" RELATED [ChEBI] xref: Wikipedia:Macromolecule is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:33842 name: aromatic annulene namespace: chebi_ontology subset: 3_STAR synonym: "aromatic annulenes" RELATED [ChEBI] is_a: CHEBI:33662 ! annulene is_a: CHEBI:33847 ! monocyclic arene [Term] id: CHEBI:33847 name: monocyclic arene namespace: chebi_ontology def: "A monocyclic aromatic hydrocarbon." [] subset: 3_STAR synonym: "monocyclic arenes" RELATED [ChEBI] is_a: CHEBI:33658 ! arene [Term] id: CHEBI:33848 name: polycyclic arene namespace: chebi_ontology def: "A polycyclic aromatic hydrocarbon." [] subset: 3_STAR synonym: "PAH" RELATED [ChEBI] synonym: "PAHs" RELATED [ChEBI] synonym: "polycyclic arenes" RELATED [ChEBI] synonym: "polycyclic aromatic hydrocarbons" RELATED [ChEBI] xref: Wikipedia:Polycyclic_aromatic_hydrocarbon is_a: CHEBI:33658 ! arene is_a: CHEBI:33666 ! polycyclic hydrocarbon relationship: RO:0000087 CHEBI:138015 ! has role endocrine disruptor relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent [Term] id: CHEBI:33853 name: phenols namespace: chebi_ontology alt_id: CHEBI:13664 alt_id: CHEBI:13825 alt_id: CHEBI:25969 alt_id: CHEBI:2857 def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." [] subset: 3_STAR synonym: "a phenol" RELATED [UniProt] synonym: "arenols" RELATED [IUPAC] synonym: "Aryl alcohol" RELATED [KEGG_COMPOUND] xref: KEGG:C15584 xref: MetaCyc:Phenols xref: Wikipedia:Phenols is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:33856 name: aromatic amino acid namespace: chebi_ontology alt_id: CHEBI:13820 alt_id: CHEBI:22623 alt_id: CHEBI:2835 def: "An amino acid whose structure includes an aromatic ring." [] subset: 3_STAR synonym: "Aromatic amino acid" EXACT [KEGG_COMPOUND] synonym: "aromatic amino acids" RELATED [ChEBI] xref: KEGG:C01021 xref: Wikipedia:Aromatic_amino_acid is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33709 ! amino acid relationship: is_conjugate_acid_of CHEBI:63473 ! aromatic amino-acid anion relationship: is_tautomer_of CHEBI:76042 ! aromatic amino-acid zwitterion [Term] id: CHEBI:33859 name: aromatic carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13817 alt_id: CHEBI:13821 alt_id: CHEBI:2830 def: "Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring." [] subset: 3_STAR synonym: "aromatic carboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:33659 ! organic aromatic compound relationship: is_conjugate_acid_of CHEBI:91007 ! aromatic carboxylate [Term] id: CHEBI:33860 name: aromatic amine namespace: chebi_ontology alt_id: CHEBI:13827 alt_id: CHEBI:22622 alt_id: CHEBI:22646 alt_id: CHEBI:2834 alt_id: CHEBI:2863 def: "An amino compound in which the amino group is linked directly to an aromatic system." [] subset: 3_STAR synonym: "aromatic amines" RELATED [ChEBI] synonym: "aryl amine" RELATED [ChEBI] synonym: "aryl amines" RELATED [ChEBI] synonym: "arylamine" RELATED [ChEBI] synonym: "arylamines" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:33861 name: transition element coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "transition element coordination entities" RELATED [ChEBI] synonym: "transition metal coordination compounds" RELATED [ChEBI] synonym: "transition metal coordination entities" RELATED [ChEBI] is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33497 ! transition element molecular entity [Term] id: CHEBI:33893 name: reagent namespace: chebi_ontology def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." [] subset: 3_STAR synonym: "reactif" RELATED [IUPAC] synonym: "reactivo" RELATED [IUPAC] synonym: "reagents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:33917 name: aldohexose namespace: chebi_ontology alt_id: CHEBI:2558 def: "A hexose with a (potential) aldehyde group at one end." [] subset: 3_STAR synonym: "aldohexose" EXACT [ChEBI] synonym: "aldohexoses" RELATED [ChEBI] is_a: CHEBI:15693 ! aldose is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:3392 name: carbendazim namespace: chebi_ontology def: "A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables." [] subset: 3_STAR synonym: "1H-benzimidazol-2-ylcarbamic acid methyl ester" RELATED [ChEBI] synonym: "2-(Methoxy-carbonylamino)-benzimidazol" RELATED [ChemIDplus] synonym: "2-(methoxycarbonylamino)-benzimidazole" RELATED [ChemIDplus] synonym: "2-(methoxycarbonylamino)benzimidazole" RELATED [ChEBI] synonym: "2-benzimidazolecarbamic acid methyl ester" RELATED [ChEBI] synonym: "BMC" RELATED [ChEBI] synonym: "Carbendazim" EXACT [KEGG_COMPOUND] synonym: "carbendazim" EXACT [UniProt] synonym: "carbendazime" RELATED [ChemIDplus] synonym: "MBC" RELATED [ChEBI] synonym: "Mecarzole" RELATED [KEGG_COMPOUND] synonym: "methyl 2-benzimidazolecarbamate" RELATED [ChemIDplus] synonym: "methyl benzimidazol-2-ylcarbamate" RELATED [ChemIDplus] xref: HMDB:HMDB0031769 xref: KEGG:C10897 xref: Patent:US3010968 xref: PPDB:116 xref: Wikipedia:Carbendazim is_a: CHEBI:87036 ! benzimidazole fungicide is_a: CHEBI:87064 ! benzimidazolylcarbamate fungicide relationship: has_functional_parent CHEBI:27822 ! 2-aminobenzimidazole relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:3393 name: carbenicillin namespace: chebi_ontology def: "A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "alpha-carboxybenzylpencillin" RELATED [ChemIDplus] synonym: "alpha-phenyl(carboxymethylpenicillin)" RELATED [ChemIDplus] synonym: "carboxybenzylpenicillin" RELATED [DrugBank] synonym: "CBPC" RELATED [ChEBI] synonym: "N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid" RELATED [ChemIDplus] xref: DrugBank:DB00578 xref: HMDB:HMDB0014717 xref: KEGG:C06869 xref: KEGG:D07614 xref: Patent:US3142673 xref: Wikipedia:Carbenicillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51897 ! carbenicillin(2-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:33937 name: macronutrient namespace: chebi_ontology def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." [] subset: 3_STAR synonym: "macronutrients" RELATED [ChEBI] is_a: CHEBI:33284 ! nutrient [Term] id: CHEBI:33958 name: halide salt namespace: chebi_ontology subset: 3_STAR synonym: "halide salts" RELATED [ChEBI] synonym: "halides" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:37578 ! halide relationship: BFO:0000051 CHEBI:16042 ! has part halide anion [Term] id: CHEBI:34043 name: 1,2-phenylenediamine namespace: chebi_ontology def: "A phenylenediamine in which the two amino groups are ortho to each other." [] subset: 3_STAR synonym: "1,2-Diaminobenzene" RELATED [KEGG_COMPOUND] synonym: "2-Aminoaniline" RELATED [ChemIDplus] synonym: "2-Phenylene diamine" RELATED [KEGG_COMPOUND] synonym: "o-Phenylenediamine" RELATED [KEGG_COMPOUND] synonym: "OPDA" RELATED [ChemIDplus] synonym: "phenylene-1,2-dimaine" RELATED [ChEBI] xref: KEGG:C14402 xref: Wikipedia:O-Phenylenediamine is_a: CHEBI:17499 ! hydrogen donor is_a: CHEBI:51402 ! phenylenediamine relationship: has_parent_hydride CHEBI:16716 ! benzene [Term] id: CHEBI:3405 name: carboxin namespace: chebi_ontology def: "An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment." [] subset: 3_STAR synonym: "2,3-Dihydro-5-carboxanilido-6-methyl-1,4-oxathiin" RELATED [ChemIDplus] synonym: "2,3-Dihydro-6-methyl-1,4-oxathiin-5-carboxanilide" RELATED [NIST_Chemistry_WebBook] synonym: "2,3-Dihydro-6-methyl-5-phenylcarbamoyl-1,4-oxathiin" RELATED [ChemIDplus] synonym: "5,6-Dihydro-2-methyl-1,4-oxathiin-3-carboxanilide" RELATED [ChemIDplus] synonym: "5,6-Dihydro-2-methyl-3-carboxanilido-1,4-oxathiin" RELATED [ChemIDplus] synonym: "5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide" RELATED [ChemIDplus] synonym: "5-Carboxanilido-2,3-dihydro-6-methyl-1,4-oxathiin" RELATED [ChemIDplus] synonym: "Carbathiin" RELATED [ChemIDplus] synonym: "Carboxine" RELATED [ChemIDplus] synonym: "oxatin" RELATED [MetaCyc] xref: KEGG:C11255 xref: LINCS:LSM-25660 xref: MetaCyc:CPD0-1366 xref: Patent:EP0042182 xref: PDBeChem:CBE xref: PPDB:122 is_a: CHEBI:13248 ! anilide is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38106 ! organosulfur heterocyclic compound is_a: CHEBI:51751 ! enamide is_a: CHEBI:87015 ! anilide fungicide relationship: RO:0000087 CHEBI:83072 ! has role EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:34608 name: captan namespace: chebi_ontology def: "A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops." [] subset: 3_STAR synonym: "1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide" RELATED [ChemIDplus] synonym: "3a,4,7,7a-Tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione" RELATED [ChemIDplus] synonym: "3a,4,7,7a-tetrahydro-N-(trichloromethanesulphenyl)phthalimide" RELATED [ChemIDplus] synonym: "captane" RELATED [ChemIDplus] synonym: "ENT 26,538" RELATED [ChemIDplus] synonym: "N-(trichloromethylmercapto)-Delta(4)-tetrahydrophthalimide" RELATED [ChemIDplus] synonym: "N-[(trichloromethyl)thio]tetrahydrophthalimide" RELATED [ChemIDplus] synonym: "N-trichloromethylmercapto-4-cyclohexene-1,2-dicarboximide" RELATED [ChemIDplus] synonym: "N-trichloromethylthio-3a,4,7,7a-tetrahydrophthalimide" RELATED [ChemIDplus] synonym: "N-trichloromethylthiocyclohex-4-ene-1,2-dicarboximide" RELATED [ChemIDplus] synonym: "SR 406" RELATED [ChemIDplus] synonym: "SR406" RELATED [ChemIDplus] xref: KEGG:C14438 xref: Patent:US2553771 xref: Patent:US2653155 xref: Patent:US2713058 xref: PPDB:114 xref: Wikipedia:Captan is_a: CHEBI:24897 ! isoindoles is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:87198 ! phthalimide fungicide relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:34653 name: Congo Red namespace: chebi_ontology def: "An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0." [] subset: 3_STAR synonym: "Congo red" EXACT [KEGG_COMPOUND] synonym: "Direct red 28" RELATED [KEGG_COMPOUND] synonym: "disodium 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(4-aminonaphthalene-1-sulphonate)" RELATED [ChemIDplus] synonym: "Kongorot" RELATED [ChemIDplus] synonym: "Sodium diphenyldiazo-bis-alpha-naphthylaminesulfonate" RELATED [KEGG_COMPOUND] xref: KEGG:C14078 is_a: CHEBI:48960 ! bis(azo) compound relationship: BFO:0000051 CHEBI:38216 ! has part 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) relationship: has_functional_parent CHEBI:38217 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) [Term] id: CHEBI:3478 name: cefaclor namespace: chebi_ontology alt_id: CHEBI:472656 def: "A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton." [] subset: 3_STAR synonym: "3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid" RELATED [ChemIDplus] synonym: "CCL" RELATED [KEGG_DRUG] synonym: "Cefaclor" EXACT [KEGG_COMPOUND] synonym: "cefaclor" EXACT [ChEMBL] synonym: "Cefaclor anhydrous" RELATED [ChemIDplus] synonym: "Cephaclor" RELATED [ChemIDplus] xref: DrugBank:DB00833 xref: HMDB:HMDB0014971 xref: KEGG:C06877 xref: KEGG:D00256 xref: LINCS:LSM-5368 xref: Patent:DE2408698 xref: Patent:US3925372 xref: Wikipedia:Cefaclor is_a: CHEBI:23066 ! cephalosporin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:3499 name: cefotetan namespace: chebi_ontology alt_id: CHEBI:558729 def: "A semi-synthetic second-generation cephamycin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl, methoxy and {[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino groups at the 3, 7alpha, and 7beta positions, respectively, of the cephem skeleton. It is resistant to a wide range of beta-lactamases and is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms." [] subset: 3_STAR synonym: "(6R,7S)-7-(4-(carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5- yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylic acid" RELATED [ChemIDplus] synonym: "Cefotetan" EXACT [KEGG_COMPOUND] synonym: "cefotetan" EXACT [ChEMBL] xref: DrugBank:DB01330 xref: KEGG:C06886 xref: KEGG:D00260 xref: LINCS:LSM-5961 xref: Patent:DE2824559 xref: Patent:US4263432 xref: Wikipedia:Cefotetan is_a: CHEBI:55429 ! cephamycin relationship: is_conjugate_acid_of CHEBI:59358 ! cefotetan(2-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:34994 name: teicoplanin A2 namespace: chebi_ontology def: "Any of the glycopeptides whose structure consists of teicoplanin A3-1 in which the hydroxy group of the di(aryloxy)-substituted phenol moiety has been converted to the corresponding 2-acylamino-2-deoxy-beta-D-glucoside. Members of the class differ only in the nature of the acyl group." [] subset: 3_STAR synonym: "teicoplanin A2-*" RELATED [ChEBI] xref: KEGG:C13781 is_a: CHEBI:22160 ! acetamides is_a: CHEBI:24396 ! glycopeptide is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:83403 ! monochlorobenzenes relationship: has_functional_parent CHEBI:34999 ! teicoplanin A3-1 relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:34995 name: teicoplanin A2-1 namespace: chebi_ontology def: "A teicoplanin A2 that has (4Z)-dec-4-enoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "(Z)-34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((1-oxo-4-decenyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "(Z)-34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(1-oxo-4-decenyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 1" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-1" EXACT [KEGG_COMPOUND] xref: KEGG:C13587 is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:34996 name: teicoplanin A2-3 namespace: chebi_ontology def: "A teicoplanin A2 that has decanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 3" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-3" EXACT [KEGG_COMPOUND] xref: KEGG:C13588 is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:34997 name: teicoplanin A2-4 namespace: chebi_ontology def: "A teicoplanin A2 that has 8-methyldecanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((8-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(8-methyl-1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 4" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-4" EXACT [KEGG_COMPOUND] xref: KEGG:C13610 is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:34998 name: teicoplanin A2-5 namespace: chebi_ontology def: "A teicoplanin A2 that has 9-methyldecanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((9-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(9-methyl-1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teichomycin A2 factor 5" RELATED [KEGG_COMPOUND] synonym: "Teicoplanin A2-5" EXACT [KEGG_COMPOUND] xref: KEGG:C13612 is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:34999 name: teicoplanin A3-1 namespace: chebi_ontology def: "A glycopeptide consisting of a macropolycyclic heptapeptide in which a phenolic hydroxy group has been converted to its alpha-D-mannoside while a secondary alcohol group has been converted to the corresponding 2-acetamido-2-deoxy-beta-D-glucoside." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "Teicoplanin A3-1" EXACT [KEGG_COMPOUND] xref: KEGG:C13613 is_a: CHEBI:22160 ! acetamides is_a: CHEBI:24396 ! glycopeptide is_a: CHEBI:26191 ! polyol is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:83403 ! monochlorobenzenes relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:35014 name: thiophanate-methyl namespace: chebi_ontology def: "A member of the class of thioureas that is the dimethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould." [] subset: 3_STAR synonym: "1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene" RELATED [ChemIDplus] synonym: "1,2-Bis(methoxycarbonylthioureido)benzene" RELATED [ChemIDplus] synonym: "1,2-Di-(3-methoxycarbonyl-2-thioureido)benzene" RELATED [ChemIDplus, KEGG_COMPOUND] synonym: "dimethyl 4,4'-(o-phenylene)bis(3-thioallophanate)" RELATED [Alan_Wood's_Pesticides] synonym: "dimethyl N,N'-[1,2-phenylenebis(azanediylcarbonothioyl)]dicarbamate" RELATED [Alan_Wood's_Pesticides] synonym: "dimethyl N,N'-[1,2-phenylenebis(iminocarbonothioyl)]bis[carbamate]" RELATED [Alan_Wood's_Pesticides] synonym: "Methyl thiophanate" RELATED [ChemIDplus] synonym: "Methylthiofanate" RELATED [ChemIDplus] synonym: "Methylthiophanate" RELATED [ChemIDplus] synonym: "o-Bis(3-methoxycarbonyl-2-thioureido)benzene" RELATED [ChemIDplus] xref: KEGG:C14432 xref: PPDB:640 is_a: CHEBI:51276 ! thioureas is_a: CHEBI:87037 ! benzimidazole precursor fungicide is_a: CHEBI:87061 ! carbamate fungicide relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:3504 name: cefpodoxime namespace: chebi_ontology alt_id: CHEBI:606443 def: "A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] xref: DrugBank:DB01416 xref: KEGG:C08114 xref: KEGG:D07650 xref: VSDB:2968 xref: Wikipedia:Cefpodoxime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:33575 ! carboxylic acid relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:3505 name: cefpodoxime proxetil namespace: chebi_ontology def: "The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pharyngitis, and sinusitis." [] subset: 3_STAR synonym: "(RS)-1-((isopropoxycarbonyl)oxy)ethyl (+)-(6R,7R)-7-(2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate" RELATED [ChemIDplus] synonym: "cefpodoxime 1-(isopropyloxycarbonyloxy)ethyl ester" RELATED [ChEBI] xref: DrugBank:DB01416 xref: KEGG:C08115 xref: KEGG:D00920 xref: Patent:EP49118 xref: Patent:US4486425 is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:33575 ! carboxylic acid relationship: has_functional_parent CHEBI:3504 ! cefpodoxime relationship: has_functional_parent CHEBI:417636 ! 4-{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl}-thiazol-2-yl-ammonium relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50266 ! has role prodrug [Term] id: CHEBI:3508 name: ceftazidime namespace: chebi_ontology def: "A third-generation cephalosporin antibiotic bearing pyridinium-1-ylmethyl and {[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "CAZ" RELATED [KEGG_DRUG] synonym: "Ceftazidime anhydrous" RELATED [ChemIDplus] xref: DrugBank:DB00438 xref: KEGG:C06889 xref: KEGG:D07654 xref: Patent:DE2921316 xref: Patent:US4258041 xref: Wikipedia:Ceftazidime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether relationship: is_conjugate_acid_of CHEBI:53676 ! ceftazidime(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50696 ! has role EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor [Term] id: CHEBI:35106 name: nitrogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "nitrogen hydrides" RELATED [ChEBI] is_a: CHEBI:35881 ! pnictogen hydride is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35107 name: azane namespace: chebi_ontology def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." [] subset: 3_STAR synonym: "azanes" RELATED [ChEBI] is_a: CHEBI:35106 ! nitrogen hydride [Term] id: CHEBI:35117 name: manganese coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "manganese coordination compounds" RELATED [ChEBI] synonym: "manganese coordination entities" RELATED [ChEBI] synonym: "manganese coordination entity" EXACT [ChEBI] is_a: CHEBI:25154 ! manganese molecular entity is_a: CHEBI:33861 ! transition element coordination entity [Term] id: CHEBI:35131 name: aldose phosphate namespace: chebi_ontology subset: 3_STAR synonym: "aldose phosphates" RELATED [ChEBI] is_a: CHEBI:33447 ! phospho sugar [Term] id: CHEBI:3515 name: cefuroxime namespace: chebi_ontology def: "A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain." [] subset: 3_STAR synonym: "(6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "Cefuroxim" RELATED [ChemIDplus] synonym: "Cefuroxime" EXACT [KEGG_COMPOUND] synonym: "Cephuroxime" RELATED [ChemIDplus] xref: DrugBank:DB01112 xref: KEGG:C06894 xref: KEGG:D00262 xref: MetaCyc:CPD0-2069 xref: Patent:DE2439880 xref: Patent:DE2706413 xref: Patent:US3974153 xref: Patent:US4267320 xref: Wikipedia:Cefuroxime is_a: CHEBI:24129 ! furans is_a: CHEBI:28084 ! 3-(carbamoyloxymethyl)cephalosporin is_a: CHEBI:36816 ! oxime O-ether [Term] id: CHEBI:35175 name: sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "sulfate salts" RELATED [ChEBI] synonym: "sulfates" RELATED [ChEBI] synonym: "sulphate salts" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:26820 ! sulfates [Term] id: CHEBI:35186 name: terpene namespace: chebi_ontology def: "A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2]." [] subset: 3_STAR synonym: "Terpen" RELATED [ChEBI] synonym: "terpene" EXACT [IUPAC] synonym: "terpenes" RELATED [IUPAC] synonym: "terpeno" RELATED [IUPAC] synonym: "terpenos" RELATED [IUPAC] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:24913 ! isoprenoid [Term] id: CHEBI:35189 name: sesquiterpene namespace: chebi_ontology def: "A C15 terpene." [] subset: 3_STAR synonym: "Sesquiterpen" RELATED [ChEBI] synonym: "sesquiterpenes" RELATED [IUPAC] synonym: "sesquiterpeno" RELATED [IUPAC] synonym: "sesquiterpenos" RELATED [IUPAC] is_a: CHEBI:35186 ! terpene [Term] id: CHEBI:35190 name: diterpene namespace: chebi_ontology def: "A C20 terpene." [] subset: 3_STAR synonym: "Diterpen" RELATED [ChEBI] synonym: "diterpenes" RELATED [IUPAC] synonym: "diterpeno" RELATED [IUPAC] synonym: "diterpenos" RELATED [IUPAC] is_a: CHEBI:35186 ! terpene [Term] id: CHEBI:35195 name: surfactant namespace: chebi_ontology def: "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces." [] subset: 3_STAR synonym: "surface active agent" RELATED [IUPAC] synonym: "surfactants" RELATED [ChEBI] is_a: CHEBI:63046 ! emulsifier [Term] id: CHEBI:35213 name: cyclodepsipeptide namespace: chebi_ontology def: "A depsipeptide in which the amino and hydroxy carboxylic acid residues are connected in a ring." [] subset: 3_STAR synonym: "Cyclodepsipeptid" RELATED [ChEBI] synonym: "Zyklodepsipeptid" RELATED [ChEBI] is_a: CHEBI:23643 ! depsipeptide is_a: CHEBI:25000 ! lactone [Term] id: CHEBI:35221 name: antimetabolite namespace: chebi_ontology def: "A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [] subset: 3_STAR synonym: "antimetabolites" RELATED [ChEBI] xref: Wikipedia:Antimetabolite is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:35222 name: inhibitor namespace: chebi_ontology def: "A substance that diminishes the rate of a chemical reaction." [] subset: 3_STAR synonym: "inhibidor" RELATED [ChEBI] synonym: "inhibiteur" RELATED [ChEBI] synonym: "inhibitors" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:35223 name: catalyst namespace: chebi_ontology def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." [] subset: 3_STAR synonym: "catalizador" RELATED [ChEBI] synonym: "catalyseur" RELATED [ChEBI] synonym: "Katalysator" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:35238 name: amino-acid zwitterion namespace: chebi_ontology def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." [] subset: 3_STAR synonym: "amino acid zwitterion" RELATED [ChEBI] synonym: "amino acid zwitterions" RELATED [ChEBI] synonym: "amino-acid zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35243 name: serine zwitterion namespace: chebi_ontology def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of serine." [] subset: 3_STAR synonym: "serine zwitterion" EXACT [IUPAC] is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:17822 ! serine [Term] id: CHEBI:35267 name: quaternary ammonium ion namespace: chebi_ontology alt_id: CHEBI:26470 alt_id: CHEBI:8693 def: "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." [] subset: 3_STAR synonym: "a quaternary ammonium" RELATED [UniProt] synonym: "Quaternary amine" RELATED [KEGG_COMPOUND] synonym: "quaternary ammonium ions" RELATED [ChEBI] xref: KEGG:C06703 is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative [Term] id: CHEBI:35274 name: ammonium ion derivative namespace: chebi_ontology def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." [] subset: 3_STAR synonym: "ammonium ion derivatives" RELATED [ChEBI] synonym: "azanium ion derivative" RELATED [ChEBI] synonym: "azanium ion derivatives" RELATED [ChEBI] is_a: CHEBI:33702 ! polyatomic cation is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_parent_hydride CHEBI:28938 ! ammonium [Term] id: CHEBI:35275 name: S-glycosyl compound namespace: chebi_ontology alt_id: CHEBI:22048 alt_id: CHEBI:33577 def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and a S atom bound to a carbon atom, thus creating a C-S bond." [] subset: 3_STAR synonym: "S-glycoside" RELATED [ChEBI] synonym: "S-glycosides" RELATED [ChEBI] synonym: "S-glycosyl compound" EXACT [ChEBI] synonym: "S-glycosyl compounds" RELATED [ChEBI] synonym: "thioglycoside" RELATED [JCBN] synonym: "thioglycosides" RELATED [JCBN] is_a: CHEBI:59793 ! monothioacetal is_a: CHEBI:63161 ! glycosyl compound is_a: CHEBI:73754 ! thiosugar [Term] id: CHEBI:35276 name: ammonium compound namespace: chebi_ontology def: "Compounds (NH4(+))Y(-) and derivatives, in which one or more of the hydrogens bonded to nitrogen have been replaced with univalent groups." [] subset: 3_STAR synonym: "ammonium compounds" RELATED [ChEBI, IUPAC] is_a: CHEBI:51143 ! nitrogen molecular entity relationship: BFO:0000051 CHEBI:35274 ! has part ammonium ion derivative [Term] id: CHEBI:35281 name: onium betaine namespace: chebi_ontology def: "Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." [] subset: 3_STAR synonym: "onium betaines" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion [Term] id: CHEBI:35285 name: iminium betaine namespace: chebi_ontology subset: 3_STAR synonym: "iminium betaines" RELATED [ChEBI] is_a: CHEBI:26469 ! quaternary nitrogen compound is_a: CHEBI:35281 ! onium betaine [Term] id: CHEBI:35286 name: iminium ion namespace: chebi_ontology def: "Cations of structure R2C=N(+)R2." [] subset: 3_STAR synonym: "iminium cations" RELATED [ChEBI] synonym: "iminium ion" EXACT [ChEBI] synonym: "iminium ions" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation [Term] id: CHEBI:35293 name: fused compound namespace: chebi_ontology def: "A polycyclic compound that contains more than one ring with at least two common atoms (also known as bridgehead carbons) that are adjacent to each other." [] subset: 3_STAR synonym: "fused compounds" RELATED [ChEBI] synonym: "fused polycyclic compounds" RELATED [ChEBI] synonym: "fused-ring polycyclic compound" RELATED [ChEBI] synonym: "fused-ring polycyclic compounds" RELATED [ChEBI] synonym: "polycyclic fused-ring compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound [Term] id: CHEBI:35294 name: carbopolycyclic compound namespace: chebi_ontology def: "A polyclic compound in which all of the ring members are carbon atoms." [] subset: 3_STAR synonym: "carbopolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33598 ! carbocyclic compound is_a: CHEBI:35295 ! homopolycyclic compound [Term] id: CHEBI:35295 name: homopolycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "homopolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33635 ! polycyclic compound [Term] id: CHEBI:35296 name: ortho-fused polycyclic arene namespace: chebi_ontology subset: 3_STAR synonym: "ortho-fused polycyclic arenes" RELATED [ChEBI] is_a: CHEBI:33848 ! polycyclic arene is_a: CHEBI:35427 ! ortho-fused polycyclic hydrocarbon [Term] id: CHEBI:35297 name: acene namespace: chebi_ontology def: "A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement." [] subset: 3_STAR synonym: "Acen" RELATED [ChEBI] synonym: "acene" EXACT [IUPAC] synonym: "Azen" RELATED [ChEBI] synonym: "polyacenes" RELATED [ChEBI] xref: Wikipedia:Acene is_a: CHEBI:35296 ! ortho-fused polycyclic arene is_a: CHEBI:51269 ! acenes [Term] id: CHEBI:35312 name: pentoside namespace: chebi_ontology subset: 3_STAR synonym: "pentoside" EXACT [ChEBI] synonym: "pentosides" RELATED [ChEBI] is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:35313 name: hexoside namespace: chebi_ontology subset: 3_STAR synonym: "hexoside" EXACT [ChEBI] synonym: "hexosides" RELATED [ChEBI] is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:3534 name: cephalexin namespace: chebi_ontology def: "A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid" RELATED [ChemIDplus] synonym: "7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid" RELATED [ChemIDplus] synonym: "Cefalexin" RELATED [KEGG_COMPOUND] synonym: "Celexin" RELATED [ChemIDplus] synonym: "Cepastar" RELATED [ChemIDplus] synonym: "Cepexin" RELATED [ChemIDplus] synonym: "Cephacillin" RELATED [ChemIDplus] synonym: "Ceporexin" RELATED [ChemIDplus] synonym: "CEX" RELATED [KEGG_DRUG] xref: DrugBank:DB00567 xref: HMDB:HMDB0014707 xref: KEGG:C06895 xref: KEGG:D00263 xref: LINCS:LSM-5957 xref: Patent:US3275626 xref: Patent:US3507861 xref: VSDB:1791 xref: Wikipedia:Cefalexin is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_conjugate_acid_of CHEBI:59392 ! cephalexin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:35341 name: steroid namespace: chebi_ontology alt_id: CHEBI:13687 alt_id: CHEBI:26768 alt_id: CHEBI:9263 def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." [] subset: 3_STAR synonym: "a steroid" RELATED [UniProt] synonym: "Steroid" EXACT [KEGG_COMPOUND] xref: KEGG:C00377 xref: MetaCyc:Steroids is_a: CHEBI:18059 ! lipid is_a: CHEBI:51958 ! organic polycyclic compound [Term] id: CHEBI:35350 name: hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:24748 alt_id: CHEBI:5814 subset: 3_STAR synonym: "hydroxy steroids" RELATED [ChEBI] synonym: "Hydroxysteroid" RELATED [KEGG_COMPOUND] synonym: "hydroxysteroids" RELATED [ChEBI] xref: KEGG:C02159 is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:35341 ! steroid [Term] id: CHEBI:35352 name: organonitrogen compound namespace: chebi_ontology def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." [] subset: 3_STAR synonym: "organonitrogens" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35356 name: dicarboximide namespace: chebi_ontology def: "An imide in which the two acyl substituents on nitrogen are carboacyl groups." [] subset: 3_STAR synonym: "dicarboximides" RELATED [ChEBI] is_a: CHEBI:24782 ! imide [Term] id: CHEBI:35358 name: sulfonamide namespace: chebi_ontology def: "An amide of a sulfonic acid RS(=O)2NR'2." [] subset: 3_STAR synonym: "sulfonamides" RELATED [ChEBI] xref: Wikipedia:Sulfonamide is_a: CHEBI:33256 ! primary amide is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:33552 ! sulfonic acid derivative [Term] id: CHEBI:35359 name: carboxamidine namespace: chebi_ontology def: "Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom." [] subset: 3_STAR synonym: "Amidines" RELATED [KEGG_COMPOUND] synonym: "carboxamidines" RELATED [ChEBI] xref: KEGG:C06060 is_a: CHEBI:2634 ! amidine is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:35362 name: hydrazide namespace: chebi_ontology def: "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC)." [] subset: 3_STAR synonym: "hydrazides" RELATED [ChEBI] is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:35363 name: carbohydrazide namespace: chebi_ontology def: "A hydrazide consisting of hydrazine carrying one or more carboacyl groups." [] subset: 3_STAR synonym: "carbohydrazides" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:35362 ! hydrazide [Term] id: CHEBI:35366 name: fatty acid namespace: chebi_ontology alt_id: CHEBI:13633 alt_id: CHEBI:24024 alt_id: CHEBI:4984 def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." [] subset: 3_STAR synonym: "acide gras" RELATED [ChEBI] synonym: "acides gras" RELATED [ChemIDplus] synonym: "acido graso" RELATED [ChEBI] synonym: "acidos grasos" RELATED [ChEBI] synonym: "Fatty acid" EXACT [KEGG_COMPOUND] synonym: "fatty acids" RELATED [ChEBI] synonym: "Fettsaeure" RELATED [ChEBI] synonym: "Fettsaeuren" RELATED [ChEBI] xref: KEGG:C00162 xref: Wikipedia:Fatty_acid is_a: CHEBI:18059 ! lipid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:28868 ! fatty acid anion [Term] id: CHEBI:35381 name: monosaccharide namespace: chebi_ontology alt_id: CHEBI:25407 alt_id: CHEBI:6984 def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." [] subset: 3_STAR synonym: "monosacarido" RELATED [ChEBI] synonym: "monosacaridos" RELATED [IUPAC] synonym: "Monosaccharid" RELATED [ChEBI] synonym: "Monosaccharide" EXACT [KEGG_COMPOUND] synonym: "Monosacharid" RELATED [ChEBI] xref: KEGG:C06698 is_a: CHEBI:16646 ! carbohydrate [Term] id: CHEBI:35406 name: oxoanion namespace: chebi_ontology alt_id: CHEBI:33274 alt_id: CHEBI:33436 def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." [] subset: 3_STAR synonym: "oxoacid anions" RELATED [ChEBI] synonym: "oxoanion" EXACT [ChEBI] synonym: "oxoanions" RELATED [ChEBI] is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion [Term] id: CHEBI:35410 name: primary diamine namespace: chebi_ontology alt_id: CHEBI:26264 alt_id: CHEBI:8408 def: "A primary diamine is a compound derived from a hydrocarbon by replacing two hydrogen atoms by amino groups." [] subset: 3_STAR synonym: "Primary diamine" EXACT [KEGG_COMPOUND] synonym: "primary diamines" RELATED [ChEBI] xref: KEGG:C02311 is_a: CHEBI:23666 ! diamine [Term] id: CHEBI:35411 name: alkane-alpha,omega-diamine namespace: chebi_ontology alt_id: CHEBI:10204 alt_id: CHEBI:13775 alt_id: CHEBI:13808 alt_id: CHEBI:22316 alt_id: CHEBI:2577 def: "A primary diamine that is ethane or a higher alkane in which a hydrogen of each of the terminal methyl groups has been replaced by an amino group. H2NCH2(CH2)nCH2NH2, where n = 0, 1, 2, etc." [] subset: 3_STAR synonym: "Alkane-alpha,omega-diamine" EXACT [KEGG_COMPOUND] synonym: "alkane-alpha,omega-diamines" RELATED [ChEBI] synonym: "alpha,omega-Diamine" RELATED [KEGG_COMPOUND] xref: KEGG:C02896 xref: KEGG:C03687 is_a: CHEBI:35410 ! primary diamine is_a: CHEBI:46687 ! diazaalkane relationship: is_conjugate_base_of CHEBI:70977 ! alkane-alpha,omega-diammonium(2+) [Term] id: CHEBI:35427 name: ortho-fused polycyclic hydrocarbon namespace: chebi_ontology subset: 3_STAR synonym: "ortho-fused polycyclic hydrocarbon" EXACT [ChEBI] synonym: "ortho-fused polycyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:33637 ! ortho-fused compound [Term] id: CHEBI:35436 name: D-glucoside namespace: chebi_ontology alt_id: CHEBI:21009 alt_id: CHEBI:4173 def: "Any glucoside in which the glycoside group is derived from D-glucose." [] subset: 3_STAR synonym: "a D-glucoside" RELATED [UniProt] synonym: "D-Glucoside" EXACT [KEGG_COMPOUND] synonym: "D-glucosides" RELATED [ChEBI] xref: KEGG:C01798 is_a: CHEBI:24278 ! glucoside [Term] id: CHEBI:35441 name: antiinfective agent namespace: chebi_ontology def: "A substance used in the prophylaxis or therapy of infectious diseases." [] subset: 3_STAR synonym: "anti-infective agents" RELATED [ChEBI] synonym: "anti-infective drugs" RELATED [ChEBI] synonym: "antiinfective agents" RELATED [ChEBI] synonym: "antiinfective drug" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35442 name: antiparasitic agent namespace: chebi_ontology def: "A substance used to treat or prevent parasitic infections." [] subset: 3_STAR synonym: "antiparasitic drugs" RELATED [ChEBI] synonym: "antiparasitics" RELATED [ChEBI] synonym: "parasiticides" RELATED [ChEBI] xref: Wikipedia:Antiparasitic is_a: CHEBI:35441 ! antiinfective agent [Term] id: CHEBI:35443 name: anthelminthic drug namespace: chebi_ontology def: "Substance intended to kill parasitic worms (helminths)." [] subset: 3_STAR synonym: "anthelminthics" RELATED [ChEBI] synonym: "anthelmintic" RELATED [IUPAC] synonym: "anthelmintics" RELATED [ChEBI] synonym: "antihelminth" RELATED [ChEBI] synonym: "antihelmintico" RELATED [ChEBI] synonym: "vermifuge" RELATED [ChEBI] is_a: CHEBI:35442 ! antiparasitic agent [Term] id: CHEBI:35444 name: antinematodal drug namespace: chebi_ontology def: "A substance used in the treatment or control of nematode infestations." [] subset: 3_STAR synonym: "antinematodal agent" RELATED [ChEBI] synonym: "antinematodal drugs" RELATED [ChEBI] synonym: "antinematodals" RELATED [ChEBI] is_a: CHEBI:25491 ! nematicide is_a: CHEBI:35443 ! anthelminthic drug [Term] id: CHEBI:35470 name: central nervous system drug namespace: chebi_ontology def: "A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system." [] subset: 3_STAR synonym: "central nervous system agents" RELATED [ChEBI] synonym: "CNS agent" RELATED [ChEBI] synonym: "CNS drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35472 name: anti-inflammatory drug namespace: chebi_ontology def: "A substance that reduces or suppresses inflammation." [] subset: 3_STAR synonym: "anti-inflammatory drugs" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory drug" RELATED [ChEBI] synonym: "antiinflammatory drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:67079 ! anti-inflammatory agent [Term] id: CHEBI:35475 name: non-steroidal anti-inflammatory drug namespace: chebi_ontology def: "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." [] subset: 3_STAR synonym: "non-steroidal anti-inflammatory agent" RELATED [ChEBI] synonym: "non-steroidal anti-inflammatory drugs" RELATED [ChEBI] synonym: "NSAID" RELATED [ChEBI] synonym: "NSAIDs" RELATED [ChEBI] xref: Wikipedia:Non-steroidal_anti-inflammatory_drug is_a: CHEBI:35472 ! anti-inflammatory drug is_a: CHEBI:35842 ! antirheumatic drug [Term] id: CHEBI:35479 name: alkali metal salt namespace: chebi_ontology subset: 3_STAR synonym: "alkali metal salts" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity [Term] id: CHEBI:35488 name: central nervous system depressant namespace: chebi_ontology def: "A loosely defined group of drugs that tend to reduce the activity of the central nervous system." [] subset: 3_STAR synonym: "central nervous system depressants" RELATED [ChEBI] synonym: "CNS depressants" RELATED [ChEBI] is_a: CHEBI:35470 ! central nervous system drug [Term] id: CHEBI:35489 name: organic disulfide namespace: chebi_ontology def: "Compounds of structure RSSR in which R and R' are organic groups." [] subset: 3_STAR synonym: "an organic disulfide" RELATED [UniProt] synonym: "organic disulfides" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:48343 ! disulfide [Term] id: CHEBI:35496 name: fluorobenzenes namespace: chebi_ontology def: "Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group." [] subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:37143 ! organofluorine compound [Term] id: CHEBI:35497 name: androgen antagonist namespace: chebi_ontology def: "A compound which inhibits or antagonises the biosynthesis or actions of androgens." [] subset: 3_STAR synonym: "antiandrogen" RELATED [ChEBI] xref: Wikipedia:Antiandrogen is_a: CHEBI:49020 ! hormone antagonist [Term] id: CHEBI:35498 name: diuretic namespace: chebi_ontology def: "An agent that promotes the excretion of urine through its effects on kidney function." [] subset: 3_STAR synonym: "diuretics" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35507 name: natural product fundamental parent namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35508 name: steroid fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "steroid fundamental parents" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:35507 ! natural product fundamental parent [Term] id: CHEBI:35515 name: 5alpha-cholestane namespace: chebi_ontology alt_id: CHEBI:20650 def: "The 5alpha-stereoisomer of cholestane." [] subset: 3_STAR synonym: "(5alpha)-cholestane" RELATED [NIST_Chemistry_WebBook] synonym: "alpha-cholestane" RELATED [NIST_Chemistry_WebBook] xref: HMDB:HMDB0041632 is_a: CHEBI:35516 ! cholestane [Term] id: CHEBI:35516 name: cholestane namespace: chebi_ontology subset: 3_STAR xref: Wikipedia:Cholestane is_a: CHEBI:35508 ! steroid fundamental parent [Term] id: CHEBI:35526 name: hypoglycemic agent namespace: chebi_ontology def: "A drug which lowers the blood glucose level." [] subset: 3_STAR synonym: "anti-hyperglycemic agent" RELATED [ChEBI] synonym: "anti-hyperglycemic agents" RELATED [ChEBI] synonym: "antidiabetic" RELATED [ChEBI] synonym: "antihyperglycemic" RELATED [ChEBI] synonym: "antihyperglycemic agent" RELATED [ChEBI] synonym: "antihyperglycemic agents" RELATED [ChEBI] synonym: "antihyperglycemic drug" RELATED [ChEBI] synonym: "antihyperglycemic drugs" RELATED [ChEBI] synonym: "antihyperglycemics" RELATED [ChEBI] synonym: "hypoglycemic agents" RELATED [ChEBI] synonym: "hypoglycemic drug" RELATED [ChEBI] synonym: "hypoglycemic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35550 name: 1H-1,2,4-triazole namespace: chebi_ontology subset: 3_STAR synonym: "s-Triazole" RELATED [NIST_Chemistry_WebBook] is_a: CHEBI:35560 ! 1,2,4-triazole relationship: is_tautomer_of CHEBI:35561 ! 3H-1,2,4-triazole relationship: is_tautomer_of CHEBI:46077 ! 4H-1,2,4-triazole [Term] id: CHEBI:35552 name: heterocyclic organic fundamental parent namespace: chebi_ontology subset: 3_STAR synonym: "heterocyclic fundamental parent" RELATED [ChEBI] synonym: "heterocyclic organic fundamental parents" RELATED [ChEBI] synonym: "organic heterocyclic fundamental parents" RELATED [ChEBI] is_a: CHEBI:33245 ! organic fundamental parent [Term] id: CHEBI:35554 name: cardiovascular drug namespace: chebi_ontology def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." [] subset: 3_STAR synonym: "cardiovascular agent" RELATED [ChEBI] synonym: "cardiovascular drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35555 name: mancude organic heteromonocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "mancude organic heteromonocyclic parents" RELATED [ChEBI] synonym: "mancude-ring organic heteromonocyclic parents" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:35571 ! mancude organic heterocyclic parent [Term] id: CHEBI:35560 name: 1,2,4-triazole namespace: chebi_ontology subset: 3_STAR xref: DrugBank:DB03594 is_a: CHEBI:38597 ! triazole [Term] id: CHEBI:35561 name: 3H-1,2,4-triazole namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:35560 ! 1,2,4-triazole relationship: is_tautomer_of CHEBI:35550 ! 1H-1,2,4-triazole relationship: is_tautomer_of CHEBI:46077 ! 4H-1,2,4-triazole [Term] id: CHEBI:35568 name: mancude ring namespace: chebi_ontology def: "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." [] subset: 3_STAR synonym: "mancude rings" RELATED [ChEBI] synonym: "mancunide-ring systems" RELATED [IUPAC] is_a: CHEBI:23367 ! molecular entity [Term] id: CHEBI:35570 name: mancude organic heterobicyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "mancude organic heterobicyclic parents" RELATED [ChEBI] synonym: "mancude-ring organic heterobicyclic parents" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:35571 ! mancude organic heterocyclic parent [Term] id: CHEBI:35571 name: mancude organic heterocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "mancude organic heterocyclic parents" RELATED [ChEBI] synonym: "mancude-ring organic heterocyclic parents" RELATED [ChEBI] is_a: CHEBI:35552 ! heterocyclic organic fundamental parent is_a: CHEBI:35573 ! organic mancude parent [Term] id: CHEBI:35573 name: organic mancude parent namespace: chebi_ontology subset: 3_STAR synonym: "organic mancude parents" RELATED [ChEBI] synonym: "organic mancude-ring parents" RELATED [ChEBI] is_a: CHEBI:33245 ! organic fundamental parent is_a: CHEBI:35568 ! mancude ring [Term] id: CHEBI:35604 name: carbon oxoanion namespace: chebi_ontology def: "A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." [] subset: 3_STAR synonym: "carbon oxoanion" EXACT [ChEBI] synonym: "carbon oxoanions" RELATED [ChEBI] synonym: "oxocarbon anion" RELATED [ChEBI] synonym: "oxocarbon anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35605 name: carbon oxoacid namespace: chebi_ontology subset: 3_STAR synonym: "carbon oxoacids" RELATED [ChEBI] synonym: "oxoacids of carbon" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35610 name: antineoplastic agent namespace: chebi_ontology def: "A substance that inhibits or prevents the proliferation of neoplasms." [] subset: 3_STAR synonym: "anticancer agent" RELATED [ChEBI] synonym: "anticancer agents" RELATED [ChEBI] synonym: "antineoplastic" RELATED [ChEBI] synonym: "antineoplastic agents" RELATED [ChEBI] synonym: "cytostatic" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35618 name: aromatic ether namespace: chebi_ontology def: "Any ether in which the oxygen is attached to at least one aryl substituent." [] subset: 3_STAR is_a: CHEBI:25698 ! ether is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:35620 name: vasodilator agent namespace: chebi_ontology def: "A drug used to cause dilation of the blood vessels." [] subset: 3_STAR synonym: "vasodilator" RELATED [ChEBI] synonym: "vasodilator agents" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:35622 name: thiazolidines namespace: chebi_ontology subset: 3_STAR synonym: "thiazolidine" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:35623 name: anticonvulsant namespace: chebi_ontology def: "A drug used to prevent seizures or reduce their severity." [] subset: 3_STAR synonym: "anti-convulsant" RELATED [ChEBI] synonym: "anti-convulsants" RELATED [ChEBI] synonym: "anti-convulsive agent" RELATED [ChEBI] synonym: "anti-convulsive agents" RELATED [ChEBI] synonym: "anticonvulsants" RELATED [ChEBI] synonym: "anticonvulsive agent" RELATED [ChEBI] synonym: "anticonvulsive agents" RELATED [ChEBI] synonym: "antiepileptic" RELATED [ChEBI] synonym: "antiepileptics" RELATED [ChEBI] synonym: "Antiepileptika" RELATED [ChEBI] synonym: "Antiepileptikum" RELATED [ChEBI] synonym: "antiepileptique" RELATED [ChEBI] synonym: "antiepileptiques" RELATED [ChEBI] synonym: "Antikonvulsiva" RELATED [ChEBI] synonym: "Antikonvulsivum" RELATED [ChEBI] is_a: CHEBI:35488 ! central nervous system depressant [Term] id: CHEBI:35625 name: EC 3.5.2.6 (beta-lactamase) inhibitor namespace: chebi_ontology def: "An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of beta-lactamase (EC 3.5.2.6)." [] subset: 3_STAR synonym: "ampicillinase inhibitor" RELATED [ChEBI] synonym: "ampicillinase inhibitors" RELATED [ChEBI] synonym: "beta-lactam hydrolase inhibitor" RELATED [ChEBI] synonym: "beta-lactam hydrolase inhibitors" RELATED [ChEBI] synonym: "beta-lactamase (EC 3.5.2.6) inhibitor" RELATED [ChEBI] synonym: "beta-lactamase (EC 3.5.2.6) inhibitors" RELATED [ChEBI] synonym: "beta-lactamase A, B, C inhibitor" RELATED [ChEBI] synonym: "beta-lactamase A, B, C inhibitors" RELATED [ChEBI] synonym: "beta-lactamase AME I inhibitor" RELATED [ChEBI] synonym: "beta-lactamase AME I inhibitors" RELATED [ChEBI] synonym: "beta-lactamase I-III inhibitor" RELATED [ChEBI] synonym: "beta-lactamase I-III inhibitors" RELATED [ChEBI] synonym: "beta-lactamase inhibitor" RELATED [ChEBI] synonym: "beta-lactamase inhibitors" RELATED [ChEBI] synonym: "cephalosporin-beta-lactamase inhibitor" RELATED [ChEBI] synonym: "cephalosporin-beta-lactamase inhibitors" RELATED [ChEBI] synonym: "cephalosporinase inhibitor" RELATED [ChEBI] synonym: "cephalosporinase inhibitors" RELATED [ChEBI] synonym: "EC 3.5.2.6 (beta-lactamase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.2.6 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.2.6 inhibitors" RELATED [ChEBI] synonym: "exopenicillinase inhibitor" RELATED [ChEBI] synonym: "exopenicillinase inhibitors" RELATED [ChEBI] synonym: "neutrapen inhibitor" RELATED [ChEBI] synonym: "neutrapen inhibitors" RELATED [ChEBI] synonym: "penicillin amido-beta-lactamhydrolase inhibitor" RELATED [ChEBI] synonym: "penicillin amido-beta-lactamhydrolase inhibitors" RELATED [ChEBI] synonym: "penicillin beta-lactamase inhibitor" RELATED [ChEBI] synonym: "penicillin beta-lactamase inhibitors" RELATED [ChEBI] synonym: "penicillinase I, II inhibitor" RELATED [ChEBI] synonym: "penicillinase I, II inhibitors" RELATED [ChEBI] synonym: "penicillinase inhibitor" RELATED [ChEBI] synonym: "penicillinase inhibitors" RELATED [ChEBI] is_a: CHEBI:76808 ! EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor [Term] id: CHEBI:35627 name: beta-lactam namespace: chebi_ontology alt_id: CHEBI:10426 alt_id: CHEBI:13203 alt_id: CHEBI:22845 def: "A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon." [] subset: 3_STAR synonym: "a beta-lactam" RELATED [UniProt] synonym: "beta-Lactam" EXACT [KEGG_COMPOUND] synonym: "beta-lactams" RELATED [ChEBI] xref: KEGG:C01866 xref: Wikipedia:Beta-lactam is_a: CHEBI:24995 ! lactam [Term] id: CHEBI:35674 name: antihypertensive agent namespace: chebi_ontology def: "Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism." [] subset: 3_STAR synonym: "antihypertensive" RELATED [ChEBI] synonym: "antihypertensive agents" RELATED [ChEBI] synonym: "antihypertensive drug" RELATED [ChEBI] synonym: "antihypertensive drugs" RELATED [ChEBI] xref: Wikipedia:Antihypertensive_drug is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:35679 name: antilipemic drug namespace: chebi_ontology def: "A substance used to treat hyperlipidemia (an excess of lipids in the blood)." [] subset: 3_STAR synonym: "antihyperlipemic" RELATED [ChEBI] synonym: "antihyperlipemics" RELATED [ChEBI] synonym: "antihyperlipidaemic agent" RELATED [ChEBI] synonym: "antihyperlipidaemic agents" RELATED [ChEBI] synonym: "antihyperlipidaemic drug" RELATED [ChEBI] synonym: "antihyperlipidaemic drugs" RELATED [ChEBI] synonym: "antihyperlipidemic" RELATED [ChEBI] synonym: "antihyperlipidemic agent" RELATED [ChEBI] synonym: "antihyperlipidemic agents" RELATED [ChEBI] synonym: "antihyperlipidemic drug" RELATED [ChEBI] synonym: "antihyperlipidemic drugs" RELATED [ChEBI] synonym: "antihyperlipidemics" RELATED [ChEBI] synonym: "antilipemic" RELATED [ChEBI] synonym: "antilipemic drugs" RELATED [ChEBI] synonym: "antilipemics" RELATED [ChEBI] synonym: "hypolipidemic agent" RELATED [ChEBI] synonym: "hypolipidemic agents" RELATED [ChEBI] synonym: "lipid-lowering agent" RELATED [ChEBI] synonym: "lipid-lowering agents" RELATED [ChEBI] synonym: "lipid-lowering drug" RELATED [ChEBI] synonym: "lipid-lowering drugs" RELATED [ChEBI] xref: Wikipedia:Hypolipidemic_agent is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35681 name: secondary alcohol namespace: chebi_ontology alt_id: CHEBI:13425 alt_id: CHEBI:13686 alt_id: CHEBI:26617 alt_id: CHEBI:58662 alt_id: CHEBI:8741 alt_id: CHEBI:9077 def: "A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it." [] subset: 3_STAR synonym: "a secondary alcohol" RELATED [UniProt] synonym: "R-CHOH-R'" RELATED [KEGG_COMPOUND] synonym: "Secondary alcohol" EXACT [KEGG_COMPOUND] synonym: "secondary alcohols" RELATED [ChEBI] xref: KEGG:C00432 xref: KEGG:C01612 is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:35689 name: tetrazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains four N atoms and one C atom." [] subset: 3_STAR is_a: CHEBI:68452 ! azole [Term] id: CHEBI:35692 name: dicarboxylic acid namespace: chebi_ontology alt_id: CHEBI:23692 alt_id: CHEBI:36172 alt_id: CHEBI:4501 def: "Any carboxylic acid containing two carboxy groups." [] subset: 3_STAR synonym: "Dicarboxylic acid" EXACT [KEGG_COMPOUND] synonym: "dicarboxylic acids" RELATED [ChEBI] xref: KEGG:C02028 is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion [Term] id: CHEBI:35693 name: dicarboxylic acid anion namespace: chebi_ontology subset: 3_STAR synonym: "dicarboxylic acid anion" EXACT [ChEBI] synonym: "dicarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid [Term] id: CHEBI:35695 name: dicarboxylic acid monoanion namespace: chebi_ontology def: "Any dicarboxylic acid anion that is a monoanion obtained by the deprotonation of only one of the carboxy groups of the dicarboxylic acid." [] subset: 3_STAR synonym: "dicarboxylic acid monoanions" RELATED [ChEBI] is_a: CHEBI:35693 ! dicarboxylic acid anion [Term] id: CHEBI:35701 name: ester namespace: chebi_ontology alt_id: CHEBI:23960 alt_id: CHEBI:4859 def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." [] subset: 3_STAR synonym: "Ester" EXACT [KEGG_COMPOUND] synonym: "esters" RELATED [ChEBI] xref: KEGG:C00287 xref: Wikipedia:Ester is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:35703 name: xenobiotic namespace: chebi_ontology alt_id: CHEBI:10074 alt_id: CHEBI:27333 def: "A xenobiotic (Greek, xenos \"foreign\"; bios \"life\") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means." [] subset: 3_STAR synonym: "Xenobiotic" EXACT [KEGG_COMPOUND] synonym: "xenobiotic compounds" RELATED [ChEBI] xref: KEGG:C06708 xref: Wikipedia:Xenobiotic is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:35705 name: immunosuppressive agent namespace: chebi_ontology def: "An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." [] subset: 3_STAR synonym: "immunosuppressant" RELATED [ChEBI] synonym: "immunosuppressive agents" RELATED [ChEBI] synonym: "inmunosupresor" RELATED [ChEBI] is_a: CHEBI:50846 ! immunomodulator [Term] id: CHEBI:35715 name: nitro compound namespace: chebi_ontology def: "A compound having a nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied)." [] subset: 3_STAR is_a: CHEBI:51143 ! nitrogen molecular entity relationship: BFO:0000051 CHEBI:29785 ! has part nitro group [Term] id: CHEBI:35716 name: C-nitro compound namespace: chebi_ontology def: "A nitro compound having the nitro group (-NO2) attached to a carbon atom." [] subset: 3_STAR is_a: CHEBI:35715 ! nitro compound is_a: CHEBI:72695 ! organic molecule relationship: is_tautomer_of CHEBI:136622 ! aci-nitro compound [Term] id: CHEBI:35718 name: antifungal agent namespace: chebi_ontology def: "An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce." [] subset: 3_STAR synonym: "antifungal" RELATED [ChEBI] synonym: "antifungal agents" RELATED [ChEBI] synonym: "antifungal drug" RELATED [ChEBI] synonym: "antifungal drugs" RELATED [ChEBI] synonym: "antifungals" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:35720 name: enrofloxacin namespace: chebi_ontology def: "A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets." [] subset: 3_STAR synonym: "Baytril" RELATED [ChemIDplus] synonym: "Enrofloxacin" EXACT [ChemIDplus] xref: HMDB:HMDB0029861 xref: KEGG:D02473 xref: LINCS:LSM-3709 xref: Patent:KR20130080422 xref: Patent:RU2491922 xref: Patent:US4659603 xref: VSDB:1762 xref: Wikipedia:Enrofloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46845 ! N-alkylpiperazine is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:51454 ! cyclopropanes relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent [Term] id: CHEBI:35727 name: triazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms." [] subset: 3_STAR synonym: "triazole compounds" RELATED [ChEBI] is_a: CHEBI:68452 ! azole [Term] id: CHEBI:35757 name: monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13657 alt_id: CHEBI:25382 alt_id: CHEBI:3407 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." [] subset: 3_STAR synonym: "a monocarboxylate" RELATED [UniProt] synonym: "Carboxylate" RELATED [KEGG_COMPOUND] synonym: "Monocarboxylate" RELATED [KEGG_COMPOUND] synonym: "monocarboxylates" RELATED [ChEBI] synonym: "monocarboxylic acid anions" RELATED [ChEBI] xref: KEGG:C00060 is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid [Term] id: CHEBI:35780 name: phosphate ion namespace: chebi_ontology def: "A phosphorus oxoanion that is the conjugate base of phosphoric acid." [] subset: 3_STAR synonym: "phosphate" RELATED [ChEBI] synonym: "phosphate ions" RELATED [ChEBI] synonym: "Pi" RELATED [ChEBI] is_a: CHEBI:33461 ! phosphorus oxoanion relationship: is_conjugate_base_of CHEBI:26078 ! phosphoric acid relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:35785 name: sphingoid namespace: chebi_ontology def: "Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds." [] subset: 3_STAR synonym: "Spd" RELATED [CBN] synonym: "sphingoid" EXACT [CBN] synonym: "sphingoid base" RELATED [CBN] synonym: "sphingoid bases" RELATED [LIPID_MAPS] synonym: "sphingoids" RELATED [ChEBI] is_a: CHEBI:26739 ! sphingolipid relationship: is_conjugate_base_of CHEBI:83876 ! cationic sphingoid [Term] id: CHEBI:35790 name: oxazole namespace: chebi_ontology def: "An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom." [] subset: 3_STAR synonym: "oxazole" EXACT [ChEBI] synonym: "oxazoles" RELATED [ChEBI] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:68452 ! azole [Term] id: CHEBI:35816 name: leprostatic drug namespace: chebi_ontology def: "A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions." [] subset: 3_STAR synonym: "leprostatic" RELATED [ChEBI] synonym: "leprostatic agent" RELATED [ChEBI] synonym: "leprostatic drugs" RELATED [ChEBI] is_a: CHEBI:64912 ! antimycobacterial drug [Term] id: CHEBI:35819 name: branched-chain fatty acid namespace: chebi_ontology alt_id: CHEBI:22919 alt_id: CHEBI:3166 def: "Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids." [] subset: 3_STAR synonym: "BCFA" RELATED [ChEBI] synonym: "BCFAs" RELATED [ChEBI] synonym: "Branched chain fatty acid" RELATED [KEGG_COMPOUND] synonym: "branched fatty acid" RELATED [ChEBI] synonym: "branched fatty acids" RELATED [ChEBI] synonym: "branched-chain fatty acids" RELATED [ChEBI] xref: KEGG:C05996 is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:58955 ! branched-chain fatty acid anion [Term] id: CHEBI:35820 name: antiprotozoal drug namespace: chebi_ontology def: "Any antimicrobial drug which is used to treat or prevent protozoal infections." [] subset: 3_STAR synonym: "antiprotozoal agent" RELATED [ChEBI] synonym: "antiprotozoal agents" RELATED [ChEBI] synonym: "antiprotozoal drugs" RELATED [ChEBI] xref: Wikipedia:Antiprotozoal_agent is_a: CHEBI:35442 ! antiparasitic agent is_a: CHEBI:36043 ! antimicrobial drug [Term] id: CHEBI:35842 name: antirheumatic drug namespace: chebi_ontology def: "A drug used to treat rheumatoid arthritis." [] subset: 3_STAR synonym: "anti-rheumatic drugs" RELATED [ChEBI] synonym: "antirheumatic agent" RELATED [ChEBI] synonym: "antirheumatic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:35850 name: sulfone namespace: chebi_ontology def: "An organosulfur compound having the structure RS(=O)2R (R =/= H)." [] subset: 3_STAR synonym: "sulfone" EXACT [ChEBI] synonym: "sulfones" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:35856 name: lipoxygenase inhibitor namespace: chebi_ontology def: "A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes." [] subset: 3_STAR synonym: "lipooxygenase inhibitor" RELATED [ChEBI] synonym: "lipoxygenase inhibitors" RELATED [ChEBI] is_a: CHEBI:76837 ! EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor [Term] id: CHEBI:35862 name: bacitracin A namespace: chebi_ontology def: "A homodetic cyclic peptide consisting of (4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid attached head-to-tail to L-leucyl,D-glutamyl, L-lysyl, D-ornityl, L-isoleucyl, D-phenylalanyl, L-histidyl. D-aspartyl and L-asparaginyl residues coupled in sequence and cyclised by condensation of the side-chain amino group of the L-lysyl residue with the C-terminal carboxylic acid group. It is the major component of bacitracin." [] subset: 3_STAR synonym: "Bacitracin A2a" RELATED [ChemIDplus] synonym: "Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-l-leucine)-" RELATED [ChemIDplus] xref: KEGG:C15482 is_a: CHEBI:15841 ! polypeptide is_a: CHEBI:24613 ! homodetic cyclic peptide relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:35868 name: hydroxy monocarboxylic acid namespace: chebi_ontology def: "Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent." [] subset: 3_STAR synonym: "hydroxy acid" RELATED [ChEBI] synonym: "hydroxy monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:24669 ! hydroxy carboxylic acid is_a: CHEBI:25384 ! monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:36059 ! hydroxy monocarboxylic acid anion [Term] id: CHEBI:35871 name: oxo monocarboxylic acid namespace: chebi_ontology def: "Any monocarboxylic acid having at least one additional oxo functional group." [] subset: 3_STAR synonym: "oxo monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:25754 ! oxo carboxylic acid relationship: is_conjugate_acid_of CHEBI:35902 ! oxo monocarboxylic acid anion [Term] id: CHEBI:35875 name: imidazopyrimidine namespace: chebi_ontology subset: 3_STAR synonym: "imidazopyrimidines" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:35881 name: pnictogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "pnictogen hydride" EXACT [ChEBI] synonym: "pnictogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33302 ! pnictogen molecular entity [Term] id: CHEBI:35902 name: oxo monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:35178 alt_id: CHEBI:35901 subset: 3_STAR synonym: "oxo monocarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:35903 ! oxo carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35871 ! oxo monocarboxylic acid [Term] id: CHEBI:35903 name: oxo carboxylic acid anion namespace: chebi_ontology def: "Any carboxylic acid anion containing at least one oxo group." [] subset: 3_STAR synonym: "oxo carboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:25754 ! oxo carboxylic acid [Term] id: CHEBI:35915 name: sterol ester namespace: chebi_ontology alt_id: CHEBI:13220 alt_id: CHEBI:15115 alt_id: CHEBI:26770 alt_id: CHEBI:26772 alt_id: CHEBI:9268 alt_id: CHEBI:9269 def: "A steroid ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of a sterol." [] subset: 3_STAR synonym: "3-hydroxysteroid ester" RELATED [ChEBI] synonym: "3-hydroxysteroid esters" RELATED [ChEBI] synonym: "a sterol ester" RELATED [UniProt] synonym: "Sterol ester" EXACT [KEGG_COMPOUND] synonym: "Steryl ester" RELATED [KEGG_COMPOUND] xref: KEGG:C01958 is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:47880 ! steroid ester [Term] id: CHEBI:35942 name: neurotransmitter agent namespace: chebi_ontology def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." [] subset: 3_STAR synonym: "neurotransmitter agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:35973 name: 3-oxo monocarboxylic acid anion namespace: chebi_ontology def: "An oxo monocarboxylic acid anion having the oxo group located at the 3-position (R = H or organyl group)." [] subset: 3_STAR synonym: "3-oxo monocarboxylic acid anions" RELATED [ChEBI] synonym: "a 3-oxo acid" RELATED [UniProt] is_a: CHEBI:35902 ! oxo monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:47881 ! 3-oxo monocarboxylic acid [Term] id: CHEBI:35983 name: 7-oxo monocarboxylic acid namespace: chebi_ontology subset: 3_STAR synonym: "7-oxo monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:35871 ! oxo monocarboxylic acid [Term] id: CHEBI:35992 name: penams namespace: chebi_ontology def: "Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5R configuration unless otherwise specified." [] subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:27933 ! beta-lactam antibiotic is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:36027 name: stilbenol namespace: chebi_ontology def: "Any stilbenoid with at least one phenolic group." [] subset: 3_STAR synonym: "stilbenol" EXACT [ChEBI] is_a: CHEBI:26776 ! stilbenoid is_a: CHEBI:33853 ! phenols [Term] id: CHEBI:36043 name: antimicrobial drug namespace: chebi_ontology def: "A drug used to treat or prevent microbial infections." [] subset: 3_STAR synonym: "antimicrobial drugs" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:35441 ! antiinfective agent [Term] id: CHEBI:36047 name: antibacterial drug namespace: chebi_ontology def: "A drug used to treat or prevent bacterial infections." [] subset: 3_STAR synonym: "antibacterial drugs" RELATED [ChEBI] xref: Wikipedia:Antibacterial is_a: CHEBI:33282 ! antibacterial agent is_a: CHEBI:36043 ! antimicrobial drug [Term] id: CHEBI:36059 name: hydroxy monocarboxylic acid anion namespace: chebi_ontology def: "Any monocarboxylic acid anion carrying at least one hydroxy substituent." [] subset: 3_STAR synonym: "hydroxy monocarboxylic acid anions" RELATED [ChEBI] synonym: "hydroxymonocarboxylic acid anion" RELATED [ChEBI] synonym: "hydroxymonocarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:35868 ! hydroxy monocarboxylic acid [Term] id: CHEBI:36080 name: protein namespace: chebi_ontology alt_id: CHEBI:13677 alt_id: CHEBI:14911 def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." [] subset: 3_STAR is_a: CHEBI:33695 ! information biomacromolecule is_a: PR:000018263 ! amino acid chain is_a: PR:000064867 ! protein-containing molecular entity equivalent_to: PR:000000001 ! protein relationship: BFO:0000051 CHEBI:16541 ! has part protein polypeptide chain [Term] id: CHEBI:36093 name: inorganic chloride namespace: chebi_ontology subset: 3_STAR synonym: "inorganic chloride salt" RELATED [ChEBI] synonym: "inorganic chloride salts" RELATED [ChEBI] synonym: "inorganic chlorides" RELATED [ChEBI] is_a: CHEBI:23114 ! chloride salt is_a: CHEBI:24839 ! inorganic salt [Term] id: CHEBI:36141 name: quinone namespace: chebi_ontology alt_id: CHEBI:13684 alt_id: CHEBI:26517 def: "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." [] subset: 3_STAR synonym: "Chinon" RELATED [ChEBI] synonym: "quinone" EXACT [IUPAC] synonym: "quinones" RELATED [ChEBI] xref: Wikipedia:Quinone is_a: CHEBI:3992 ! cyclic ketone [Term] id: CHEBI:36233 name: disaccharide namespace: chebi_ontology alt_id: CHEBI:23844 alt_id: CHEBI:4654 def: "A compound in which two monosaccharides are joined by a glycosidic bond." [] subset: 3_STAR synonym: "disacarido" RELATED [ChEBI] synonym: "disacaridos" RELATED [IUPAC] synonym: "Disaccharid" RELATED [ChEBI] synonym: "Disaccharide" EXACT [KEGG_COMPOUND] synonym: "Disacharid" RELATED [ChEBI] xref: KEGG:C01911 is_a: CHEBI:50699 ! oligosaccharide [Term] id: CHEBI:36244 name: dicarboxylic acid monoester namespace: chebi_ontology def: "A monoester of a dicarboxylic acid." [] subset: 3_STAR synonym: "dicarboxylic acid monoesters" RELATED [ChEBI] is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:131605 ! dicarboxylic acid monoester(1-) [Term] id: CHEBI:36335 name: trypanocidal drug namespace: chebi_ontology def: "A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida." [] subset: 3_STAR synonym: "antitrypanosomal agent" RELATED [ChEBI] synonym: "antitrypanosomal agents" RELATED [ChEBI] synonym: "antitrypanosomal drug" RELATED [ChEBI] synonym: "antitrypanosomal drugs" RELATED [ChEBI] synonym: "trypanocidal drugs" RELATED [ChEBI] synonym: "trypanocide" RELATED [ChEBI] synonym: "trypanosomicidal agents" RELATED [ChEBI] is_a: CHEBI:35820 ! antiprotozoal drug [Term] id: CHEBI:36336 name: naphthalenesulfonic acid namespace: chebi_ontology subset: 3_STAR synonym: "naphthalenesulfonic acids" RELATED [ChEBI] is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:33555 ! arenesulfonic acid [Term] id: CHEBI:36338 name: lepton namespace: chebi_ontology def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." [] subset: 3_STAR synonym: "leptons" RELATED [ChEBI] is_a: CHEBI:33233 ! fundamental particle is_a: CHEBI:36340 ! fermion [Term] id: CHEBI:36339 name: baryon namespace: chebi_ontology def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." [] subset: 3_STAR synonym: "baryons" RELATED [ChEBI] is_a: CHEBI:36340 ! fermion is_a: CHEBI:36344 ! hadron [Term] id: CHEBI:36340 name: fermion namespace: chebi_ontology def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." [] subset: 3_STAR synonym: "fermions" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36342 name: subatomic particle namespace: chebi_ontology def: "A particle smaller than an atom." [] subset: 3_STAR synonym: "subatomic particles" RELATED [ChEBI] xref: Wikipedia:Subatomic_particle [Term] id: CHEBI:36343 name: composite particle namespace: chebi_ontology def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." [] subset: 3_STAR synonym: "composite particles" RELATED [ChEBI] is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36344 name: hadron namespace: chebi_ontology def: "Hadron is a subatomic particle which experiences the strong force." [] subset: 3_STAR synonym: "hadrons" RELATED [ChEBI] is_a: CHEBI:36343 ! composite particle [Term] id: CHEBI:36347 name: nuclear particle namespace: chebi_ontology def: "A nucleus or any of its constituents in any of their energy states." [] subset: 3_STAR is_a: CHEBI:36342 ! subatomic particle [Term] id: CHEBI:36357 name: polyatomic entity namespace: chebi_ontology def: "Any molecular entity consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: BFO:0000051 CHEBI:24433 ! has part group [Term] id: CHEBI:36358 name: polyatomic ion namespace: chebi_ontology def: "An ion consisting of more than one atom." [] subset: 3_STAR synonym: "polyatomic ions" RELATED [ChEBI] is_a: CHEBI:24870 ! ion is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:36359 name: phosphorus oxoacid derivative namespace: chebi_ontology subset: 3_STAR synonym: "phosphorus oxoacid derivative" EXACT [ChEBI] is_a: CHEBI:33241 ! oxoacid derivative is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives relationship: has_functional_parent CHEBI:33457 ! phosphorus oxoacid [Term] id: CHEBI:36360 name: phosphorus oxoacids and derivatives namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26082 ! phosphorus molecular entity [Term] id: CHEBI:36361 name: phosphorous acid namespace: chebi_ontology alt_id: CHEBI:26081 alt_id: CHEBI:29196 subset: 3_STAR synonym: "[P(OH)3]" RELATED [IUPAC] synonym: "H3PO3" RELATED [IUPAC, NIST_Chemistry_WebBook] synonym: "P(OH)3" RELATED [IUPAC] synonym: "phosphite" RELATED [UniProt] synonym: "phosphorige Saeure" RELATED [ChEBI] synonym: "phosphorous acid" EXACT [IUPAC] is_a: CHEBI:33457 ! phosphorus oxoacid relationship: is_conjugate_acid_of CHEBI:29258 ! dihydrogenphosphite relationship: is_tautomer_of CHEBI:44976 ! phosphonic acid [Term] id: CHEBI:36386 name: dichloroacetic acid namespace: chebi_ontology alt_id: CHEBI:23695 alt_id: CHEBI:4502 alt_id: CHEBI:49918 def: "An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis." [] subset: 3_STAR synonym: "2,2-dichloroacetic acid" RELATED [ChemIDplus] synonym: "bichloracetic acid" RELATED [NIST_Chemistry_WebBook] synonym: "dichloracetic acid" RELATED [NIST_Chemistry_WebBook] synonym: "Dichloressigsaeure" RELATED [ChEBI] synonym: "DICHLORO-ACETIC ACID" RELATED [PDBeChem] synonym: "Dichloroacetate" RELATED [KEGG_COMPOUND] xref: DrugBank:DB08809 xref: KEGG:C11149 xref: LINCS:LSM-5314 xref: MetaCyc:CPD-9674 xref: PDBeChem:TF4 xref: Wikipedia:Dichloroacetic_acid is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:36683 ! organochlorine compound relationship: has_functional_parent CHEBI:15366 ! acetic acid relationship: is_conjugate_acid_of CHEBI:28240 ! dichloroacetate relationship: RO:0000087 CHEBI:74783 ! has role astringent relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite [Term] id: CHEBI:36388 name: saturated organic heterocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "saturated heterocyclic parent hydride" RELATED [ChEBI] synonym: "saturated heterocyclic parent hydrides" RELATED [ChEBI] synonym: "saturated organic heterocyclic parents" RELATED [ChEBI] is_a: CHEBI:35552 ! heterocyclic organic fundamental parent [Term] id: CHEBI:36389 name: saturated organic heteromonocyclic parent namespace: chebi_ontology subset: 3_STAR synonym: "saturated heteromonocyclic parent hydride" RELATED [ChEBI] synonym: "saturated heteromonocyclic parent hydrides" RELATED [ChEBI] synonym: "saturated organic heteromonocyclic parents" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:36388 ! saturated organic heterocyclic parent [Term] id: CHEBI:3639 name: chlorothalonil namespace: chebi_ontology def: "A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops." [] subset: 3_STAR synonym: "1,3-Dicyanotetrachlorobenzene" RELATED [ChemIDplus] synonym: "2,4,5,6-Tetrachloro-3-cyanobenzonitrile" RELATED [ChemIDplus] synonym: "Chlorothalonil" EXACT [KEGG_COMPOUND] synonym: "chlorothalonil" EXACT [UniProt] synonym: "m-TCPN" RELATED [ChemIDplus] synonym: "m-Tetrachlorophthalonitrile" RELATED [ChemIDplus] synonym: "meta-TCPN" RELATED [ChemIDplus] synonym: "meta-Tetrachlorophthalodinitrile" RELATED [ChemIDplus] synonym: "Tetrachloroisophthalonitrile" RELATED [KEGG_COMPOUND] synonym: "TPN" RELATED [KEGG_COMPOUND] xref: KEGG:C11037 xref: Patent:US3290353 xref: Patent:US3652637 xref: PPDB:150 xref: Wikipedia:Chlorothalonil is_a: CHEBI:26888 ! tetrachlorobenzene is_a: CHEBI:51308 ! dinitrile is_a: CHEBI:87034 ! aromatic fungicide relationship: has_functional_parent CHEBI:38218 ! isophthalonitrile relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:36563 name: zinc group coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc group coordination compounds" RELATED [ChEBI] synonym: "zinc group coordination entities" RELATED [ChEBI] is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33673 ! zinc group molecular entity [Term] id: CHEBI:36566 name: zinc coordination entity namespace: chebi_ontology subset: 3_STAR synonym: "zinc coordination compounds" RELATED [ChEBI] synonym: "zinc coordination entities" RELATED [ChEBI] is_a: CHEBI:27364 ! zinc molecular entity is_a: CHEBI:36563 ! zinc group coordination entity [Term] id: CHEBI:36586 name: carbonyl compound namespace: chebi_ontology def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." [] subset: 3_STAR is_a: CHEBI:36587 ! organic oxo compound is_a: CHEBI:36963 ! organooxygen compound relationship: BFO:0000051 CHEBI:23019 ! has part carbonyl group [Term] id: CHEBI:36587 name: organic oxo compound namespace: chebi_ontology def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." [] subset: 3_STAR synonym: "organic oxo compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule relationship: BFO:0000051 CHEBI:46629 ! has part oxo group [Term] id: CHEBI:36622 name: benzimidazole namespace: chebi_ontology def: "A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings." [] subset: 3_STAR synonym: "Benzimidazol" RELATED [ChEBI] xref: Wikipedia:Benzimidazole is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:35570 ! mancude organic heterobicyclic parent [Term] id: CHEBI:36623 name: 4H-benzimidazole namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:36622 ! benzimidazole relationship: is_tautomer_of CHEBI:36639 ! 2H-benzimidazole relationship: is_tautomer_of CHEBI:36641 ! 3aH-benzimidazole relationship: is_tautomer_of CHEBI:41275 ! 1H-benzimidazole [Term] id: CHEBI:36624 name: naphthyridine namespace: chebi_ontology def: "Any one of eight organic heterobicyclic compounds that have a naphthalene skeleton in which two of the carbons are replaced by nitrogens. A 'closed' class." [] subset: 3_STAR xref: Wikipedia:Naphthyridine is_a: CHEBI:35570 ! mancude organic heterobicyclic parent is_a: CHEBI:50893 ! azaarene is_a: CHEBI:52362 ! ortho-fused heteroarene [Term] id: CHEBI:36628 name: 1,8-naphthyridine namespace: chebi_ontology def: "A naphthyridine in which the nitrogens are situated at positions 1 and 8." [] subset: 3_STAR synonym: "1,8-diazanaphthalene" RELATED [NIST_Chemistry_WebBook] synonym: "1,8-pyridopyridine" RELATED [NIST_Chemistry_WebBook] synonym: "napy" RELATED [IUPAC] is_a: CHEBI:36624 ! naphthyridine [Term] id: CHEBI:36639 name: 2H-benzimidazole namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:36622 ! benzimidazole relationship: is_tautomer_of CHEBI:36623 ! 4H-benzimidazole relationship: is_tautomer_of CHEBI:36641 ! 3aH-benzimidazole relationship: is_tautomer_of CHEBI:41275 ! 1H-benzimidazole [Term] id: CHEBI:36641 name: 3aH-benzimidazole namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:36622 ! benzimidazole relationship: is_tautomer_of CHEBI:36623 ! 4H-benzimidazole relationship: is_tautomer_of CHEBI:36639 ! 2H-benzimidazole relationship: is_tautomer_of CHEBI:41275 ! 1H-benzimidazole [Term] id: CHEBI:36683 name: organochlorine compound namespace: chebi_ontology def: "An organochlorine compound is a compound containing at least one carbon-chlorine bond." [] subset: 3_STAR synonym: "an organochlorine molecule" RELATED [UniProt] synonym: "chloroorganic compounds" RELATED [ChEBI] synonym: "chlororganische Verbindungen" RELATED [ChEBI] synonym: "organochloride" RELATED [ChEBI] synonym: "organochloride compound" RELATED [ChEBI] synonym: "organochloride compounds" RELATED [ChEBI] synonym: "organochlorides" RELATED [ChEBI] synonym: "organochlorine compound" EXACT [ChEBI] synonym: "organochlorine compounds" RELATED [ChEBI] xref: MetaCyc:Chlorides xref: Wikipedia:Organochloride is_a: CHEBI:17792 ! organohalogen compound is_a: CHEBI:23117 ! chlorine molecular entity [Term] id: CHEBI:36688 name: heterotricyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterotricyclic compound" EXACT [ChEBI] synonym: "heterotricyclic compounds" RELATED [ChEBI] is_a: CHEBI:33671 ! heteropolycyclic compound [Term] id: CHEBI:36700 name: phosphocholines namespace: chebi_ontology def: "Any compound having phosphocholine as part of its structure." [] subset: 3_STAR synonym: "choline phosphates" RELATED [ChEBI] synonym: "O-phosphocholines" RELATED [ChEBI] synonym: "phosphorylcholines" RELATED [ChEBI] is_a: CHEBI:23213 ! choline ester is_a: CHEBI:23217 ! cholines is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester [Term] id: CHEBI:36709 name: aminoquinoline namespace: chebi_ontology def: "Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups." [] subset: 3_STAR synonym: "aminoquinoline" EXACT [ChEBI] synonym: "aminoquinolines" RELATED [ChEBI] is_a: CHEBI:26513 ! quinolines is_a: CHEBI:33860 ! aromatic amine [Term] id: CHEBI:36756 name: farnesane namespace: chebi_ontology def: "A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10." [] subset: 3_STAR synonym: "Farnesan" RELATED [NIST_Chemistry_WebBook] synonym: "farnesane" EXACT [NIST_Chemistry_WebBook] xref: MetaCyc:CPD-8764 xref: Patent:US2008098645 xref: Patent:US7399323 is_a: CHEBI:18310 ! alkane is_a: CHEBI:35189 ! sesquiterpene relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite [Term] id: CHEBI:36757 name: farnesane sesquiterpenoid namespace: chebi_ontology subset: 3_STAR synonym: "farnesane sesquiterpenoid" EXACT [ChEBI] synonym: "farnesane sesquiterpenoids" RELATED [ChEBI] is_a: CHEBI:26658 ! sesquiterpenoid relationship: has_parent_hydride CHEBI:36756 ! farnesane [Term] id: CHEBI:36785 name: carbobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which all the ring atoms are carbon." [] subset: 3_STAR synonym: "carbobicyclic compounds" RELATED [ChEBI] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:35294 ! carbopolycyclic compound [Term] id: CHEBI:36816 name: oxime O-ether namespace: chebi_ontology def: "O-organyl oximes R2C=NOR' (R' =/= H)." [] subset: 3_STAR synonym: "O-substituted oximes" RELATED [ChEBI] synonym: "oxime ether" RELATED [ChEBI] synonym: "oxime ethers" RELATED [ChEBI] synonym: "oxime O-ether" EXACT [IUPAC] synonym: "oxime O-ethers" RELATED [ChEBI] is_a: CHEBI:25698 ! ether is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:36820 name: ring assembly namespace: chebi_ontology def: "Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved." [] subset: 3_STAR is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:36823 name: pseudohalo group namespace: chebi_ontology subset: 3_STAR synonym: "halogenoid group" RELATED [ChEBI] synonym: "pseudohalido group" RELATED [ChEBI] synonym: "pseudohalo groups" RELATED [ChEBI] synonym: "pseudohalogen group" RELATED [IUPAC] is_a: CHEBI:24433 ! group [Term] id: CHEBI:36828 name: pseudohalide anion namespace: chebi_ontology subset: 3_STAR synonym: "pseudohalide anions" RELATED [ChEBI] synonym: "pseudohalides" RELATED [ChEBI] synonym: "pseudohalogen anion" RELATED [ChEBI] synonym: "pseudohalogen ion" RELATED [ChEBI] is_a: CHEBI:36829 ! polyatomic monoanion [Term] id: CHEBI:36829 name: polyatomic monoanion namespace: chebi_ontology subset: 3_STAR synonym: "polyatomic monoanions" RELATED [ChEBI] is_a: CHEBI:33273 ! polyatomic anion is_a: CHEBI:36830 ! monoanion [Term] id: CHEBI:36830 name: monoanion namespace: chebi_ontology subset: 3_STAR synonym: "monoanions" RELATED [ChEBI] is_a: CHEBI:22563 ! anion [Term] id: CHEBI:36834 name: 3-hydroxy steroid namespace: chebi_ontology def: "Any hydroxy steroid carrying a hydroxy group at position 3." [] subset: 3_STAR synonym: "3-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:35350 ! hydroxy steroid [Term] id: CHEBI:36835 name: 3alpha-hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:71194 def: "A 3-hydroxy steroid in which the 3-hydroxy substituent is in the alpha-position." [] subset: 3_STAR synonym: "3alpha-hydroxy steroids" RELATED [ChEBI] synonym: "3alpha-hydroxysteroid" RELATED [ChEBI] synonym: "3alpha-hydroxysteroids" RELATED [ChEBI] synonym: "a 3alpha-hydroxysteroid" RELATED [UniProt] xref: MetaCyc:3-alpha-Hydroxysteroids is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:36834 ! 3-hydroxy steroid [Term] id: CHEBI:36841 name: 11-hydroxy steroid namespace: chebi_ontology subset: 3_STAR synonym: "11-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:35350 ! hydroxy steroid [Term] id: CHEBI:36856 name: hydrogen isocyanide namespace: chebi_ontology subset: 3_STAR synonym: "CNH" RELATED [ChEBI] synonym: "HN(+)#C(-)" RELATED [IUPAC] synonym: "HNC" RELATED [NIST_Chemistry_WebBook] synonym: "hydrogen isocyanide" EXACT [NIST_Chemistry_WebBook] synonym: "hydroisocyanic acid" RELATED [ChEBI] is_a: CHEBI:33405 ! hydracid relationship: is_conjugate_acid_of CHEBI:17514 ! cyanide relationship: is_tautomer_of CHEBI:18407 ! hydrogen cyanide [Term] id: CHEBI:36902 name: chalcogen hydride namespace: chebi_ontology subset: 3_STAR synonym: "chalcogen hydride" EXACT [ChEBI] synonym: "chalcogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36914 name: inorganic ion namespace: chebi_ontology subset: 3_STAR synonym: "inorganic ions" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36915 name: inorganic cation namespace: chebi_ontology subset: 3_STAR synonym: "inorganic cations" RELATED [ChEBI] is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:36916 ! cation [Term] id: CHEBI:36916 name: cation namespace: chebi_ontology alt_id: CHEBI:23058 alt_id: CHEBI:3473 def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." [] subset: 3_STAR synonym: "Cation" EXACT [KEGG_COMPOUND] synonym: "cation" EXACT [ChEBI] synonym: "cationes" RELATED [ChEBI] synonym: "cations" RELATED [ChEBI] synonym: "Kation" RELATED [ChEBI] synonym: "Kationen" RELATED [ChEBI] xref: KEGG:C01373 is_a: CHEBI:24870 ! ion [Term] id: CHEBI:36961 name: chalcocarbonic acid namespace: chebi_ontology subset: 3_STAR synonym: "chalcocarbonic acid" EXACT [ChEBI] synonym: "chalcocarbonic acids" RELATED [ChEBI] is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:36962 name: organochalcogen compound namespace: chebi_ontology def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." [] subset: 3_STAR synonym: "organochalcogen compound" EXACT [ChEBI] synonym: "organochalcogen compounds" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33304 ! chalcogen molecular entity [Term] id: CHEBI:36963 name: organooxygen compound namespace: chebi_ontology def: "An organochalcogen compound containing at least one carbon-oxygen bond." [] subset: 3_STAR synonym: "organooxygen compound" EXACT [ChEBI] synonym: "organooxygen compounds" RELATED [ChEBI] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:36962 ! organochalcogen compound [Term] id: CHEBI:36976 name: nucleotide namespace: chebi_ontology alt_id: CHEBI:13215 alt_id: CHEBI:13663 alt_id: CHEBI:7656 def: "A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid." [] subset: 3_STAR synonym: "Nucleotide" EXACT [KEGG_COMPOUND] synonym: "nucleotides" RELATED [ChEBI] xref: KEGG:C00215 xref: Wikipedia:Nucleotide is_a: CHEBI:25608 ! nucleoside phosphate [Term] id: CHEBI:36982 name: cyclic purine nucleotide namespace: chebi_ontology subset: 3_STAR synonym: "cyclic purine nucleotides" RELATED [ChEBI] is_a: CHEBI:23447 ! cyclic nucleotide is_a: CHEBI:26395 ! purine nucleotide [Term] id: CHEBI:36988 name: 5'-deoxyribonucleoside namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:23636 ! deoxyribonucleoside [Term] id: CHEBI:37022 name: amino-acid anion namespace: chebi_ontology subset: 3_STAR synonym: "amino acid anion" RELATED [ChEBI] synonym: "amino acid anions" RELATED [ChEBI] synonym: "amino-acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion is_a: CHEBI:35352 ! organonitrogen compound relationship: is_conjugate_base_of CHEBI:33709 ! amino acid [Term] id: CHEBI:37142 name: organoiodine compound namespace: chebi_ontology def: "An organoiodine compound is a compound containing at least one carbon-iodine bond." [] subset: 3_STAR synonym: "organoiodine compound" EXACT [ChEBI] synonym: "organoiodine compounds" RELATED [ChEBI] xref: MetaCyc:Organoiodine-Compounds xref: Wikipedia:Organoiodine_compound is_a: CHEBI:17792 ! organohalogen compound is_a: CHEBI:24860 ! iodine molecular entity [Term] id: CHEBI:37143 name: organofluorine compound namespace: chebi_ontology def: "An organofluorine compound is a compound containing at least one carbon-fluorine bond." [] subset: 3_STAR synonym: "fluoroorganic compound" RELATED [ChEBI] synonym: "fluoroorganic compounds" RELATED [ChEBI] synonym: "fluoroorganics" RELATED [ChEBI] synonym: "fluororganische Verbindungen" RELATED [ChEBI] synonym: "organofluorine compound" EXACT [ChEBI] synonym: "organofluorine compounds" RELATED [ChEBI] xref: MetaCyc:Fluorides is_a: CHEBI:17792 ! organohalogen compound is_a: CHEBI:24062 ! fluorine molecular entity [Term] id: CHEBI:37153 name: EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor namespace: chebi_ontology alt_id: CHEBI:62670 def: "Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16)." [] subset: 3_STAR synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor" RELATED [ChEBI] synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors" RELATED [ChEBI] synonym: "Aspergillus awamori acid protein phosphatase inhibitor" RELATED [ChEBI] synonym: "Aspergillus awamori acid protein phosphatase inhibitors" RELATED [ChEBI] synonym: "BCKDH phosphatase inhibitor" RELATED [ChEBI] synonym: "BCKDH phosphatase inhibitors" RELATED [ChEBI] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor" RELATED [ChEBI] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors" RELATED [ChEBI] synonym: "calcineurin inhibitor" RELATED [ChEBI] synonym: "calcineurin inhibitors" RELATED [ChEBI] synonym: "casein phosphatase inhibitor" RELATED [ChEBI] synonym: "casein phosphatase inhibitors" RELATED [ChEBI] synonym: "EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.3.16 inhibitor" RELATED [ChEBI] synonym: "EC 3.1.3.16 inhibitors" RELATED [ChEBI] synonym: "HMG-CoA reductase phosphatase inhibitor" RELATED [ChEBI] synonym: "HMG-CoA reductase phosphatase inhibitors" RELATED [ChEBI] synonym: "phosphatase 2A inhibitor" RELATED [ChEBI] synonym: "phosphatase 2A inhibitors" RELATED [ChEBI] synonym: "phosphatase 2B inhibitor" RELATED [ChEBI] synonym: "phosphatase 2B inhibitors" RELATED [ChEBI] synonym: "phosphatase C-II inhibitor" RELATED [ChEBI] synonym: "phosphatase C-II inhibitors" RELATED [ChEBI] synonym: "phosphatase H-II inhibitor" RELATED [ChEBI] synonym: "phosphatase H-II inhibitors" RELATED [ChEBI] synonym: "phosphatase I inhibitor" RELATED [ChEBI] synonym: "phosphatase I inhibitors" RELATED [ChEBI] synonym: "phosphatase IB inhibitor" RELATED [ChEBI] synonym: "phosphatase IB inhibitors" RELATED [ChEBI] synonym: "phosphatase II inhibitor" RELATED [ChEBI] synonym: "phosphatase II inhibitors" RELATED [ChEBI] synonym: "phosphatase III inhibitor" RELATED [ChEBI] synonym: "phosphatase III inhibitors" RELATED [ChEBI] synonym: "phosphatase IV inhibitor" RELATED [ChEBI] synonym: "phosphatase IV inhibitors" RELATED [ChEBI] synonym: "phosphatase SP inhibitor" RELATED [ChEBI] synonym: "phosphatase SP inhibitors" RELATED [ChEBI] synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitor" RELATED [ChEBI] synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitors" RELATED [ChEBI] synonym: "phosphoprotein phosphatase inhibitor" RELATED [ChEBI] synonym: "phosphoprotein phosphatase inhibitors" RELATED [ChEBI] synonym: "phosphoprotein phosphohydrolase inhibitor" RELATED [ChEBI] synonym: "phosphoprotein phosphohydrolase inhibitors" RELATED [ChEBI] synonym: "phosphopyruvate dehydrogenase phosphatase inhibitor" RELATED [ChEBI] synonym: "phosphopyruvate dehydrogenase phosphatase inhibitors" RELATED [ChEBI] synonym: "phosphospectrin phosphatase inhibitor" RELATED [ChEBI] synonym: "phosphospectrin phosphatase inhibitors" RELATED [ChEBI] synonym: "polycation modulated (PCM-) phosphatase inhibitor" RELATED [ChEBI] synonym: "polycation modulated (PCM-) phosphatase inhibitors" RELATED [ChEBI] synonym: "protein D phosphatase inhibitor" RELATED [ChEBI] synonym: "protein D phosphatase inhibitors" RELATED [ChEBI] synonym: "protein phosphatase inhibitor" RELATED [ChEBI] synonym: "protein phosphatase inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-1 inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-1 inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-2A inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-2A inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-2B inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-2B inhibitors" RELATED [ChEBI] synonym: "protein phosphatase-2C inhibitor" RELATED [ChEBI] synonym: "protein phosphatase-2C inhibitors" RELATED [ChEBI] synonym: "protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors" RELATED [ChEBI] synonym: "protein serine/threonine phosphatase inhibitor" RELATED [ChEBI] synonym: "protein serine/threonine phosphatase inhibitors" RELATED [ChEBI] synonym: "serine/threonine specific protein phosphatase inhibitor" RELATED [ChEBI] synonym: "serine/threonine specific protein phosphatase inhibitors" RELATED [ChEBI] xref: Wikipedia:Phosphoprotein_phosphatase xref: Wikipedia:Protein_serine/threonine_phosphatase is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor [Term] id: CHEBI:37175 name: organic hydride namespace: chebi_ontology subset: 3_STAR synonym: "organic hydrides" RELATED [ChEBI] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37176 name: mononuclear parent hydride namespace: chebi_ontology subset: 3_STAR synonym: "mononuclear hydride" RELATED [ChEBI] synonym: "mononuclear hydrides" RELATED [IUPAC] is_a: CHEBI:33692 ! hydrides [Term] id: CHEBI:37206 name: hexol namespace: chebi_ontology def: "A polyol that contains 6 hydroxy groups." [] subset: 3_STAR synonym: "hexols" RELATED [ChEBI] is_a: CHEBI:26191 ! polyol [Term] id: CHEBI:37246 name: elemental sodium namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26712 ! sodium molecular entity [Term] id: CHEBI:37247 name: elemental potassium namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:26217 ! potassium molecular entity [Term] id: CHEBI:3732 name: clarithromycin namespace: chebi_ontology alt_id: CHEBI:41676 alt_id: CHEBI:442148 alt_id: CHEBI:670147 def: "The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis." [] subset: 3_STAR synonym: "6-O-methylerythromycin" RELATED [ChemIDplus] synonym: "6-O-methylerythromycin A" RELATED [ChemIDplus] synonym: "CLA" RELATED [DrugBank] synonym: "CLARITHROMYCIN" EXACT [PDBeChem] synonym: "Clarithromycin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB01211 xref: KEGG:C06912 xref: KEGG:D00276 xref: LINCS:LSM-5606 xref: Patent:EP41355 xref: Patent:US4331803 xref: PDBeChem:CTY is_a: CHEBI:25105 ! macrolide antibiotic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:37404 name: elemental copper namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:23377 ! copper molecular entity [Term] id: CHEBI:37407 name: cyclic ether namespace: chebi_ontology alt_id: CHEBI:37406 def: "Any ether in which the oxygen atom forms part of a ring." [] subset: 3_STAR synonym: "cyclic ether" EXACT [IUPAC] synonym: "cyclic ethers" RELATED [ChEBI] synonym: "epoxy compounds" RELATED [ChEBI] is_a: CHEBI:25698 ! ether is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:37416 name: EC 2.7.7.6 (RNA polymerase) inhibitor namespace: chebi_ontology def: "An EC 2.7.7.* (nucleotidyltransferase) inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6)." [] subset: 3_STAR synonym: "C ribonucleic acid formation factors inhibitor" RELATED [ChEBI] synonym: "C ribonucleic acid formation factors inhibitors" RELATED [ChEBI] synonym: "C RNA formation factors inhibitor" RELATED [ChEBI] synonym: "C RNA formation factors inhibitors" RELATED [ChEBI] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitor" RELATED [ChEBI] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitors" RELATED [ChEBI] synonym: "directed RNA polymerase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "DNA-dependent RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "DNA-dependent RNA polymerase inhibitor" RELATED [ChEBI] synonym: "DNA-dependent RNA polymerase inhibitors" RELATED [ChEBI] synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "DNA-directed RNA polymerase inhibitor" RELATED [ChEBI] synonym: "DNA-directed RNA polymerase inhibitors" RELATED [ChEBI] synonym: "EC 2.7.7.6 (RNA polymerase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.7.6 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.7.6 inhibitors" RELATED [ChEBI] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [ChEBI] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [ChEBI] synonym: "ribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "ribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "ribonucleate polymerase inhibitor" RELATED [ChEBI] synonym: "ribonucleate polymerase inhibitors" RELATED [ChEBI] synonym: "ribonucleic acid nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "ribonucleic acid nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "ribonucleic acid polymerase inhibitor" RELATED [ChEBI] synonym: "ribonucleic acid polymerase inhibitors" RELATED [ChEBI] synonym: "ribonucleic acid transcriptase inhibitor" RELATED [ChEBI] synonym: "ribonucleic acid transcriptase inhibitors" RELATED [ChEBI] synonym: "ribonucleic polymerase inhibitor" RELATED [ChEBI] synonym: "ribonucleic polymerase inhibitors" RELATED [ChEBI] synonym: "ribonucleic transcriptase inhibitor" RELATED [ChEBI] synonym: "ribonucleic transcriptase inhibitors" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] synonym: "RNA polymerase (EC 2.7.7.6) inhibitor" RELATED [ChEBI] synonym: "RNA polymerase (EC 2.7.7.6) inhibitors" RELATED [ChEBI] synonym: "RNA polymerase I inhibitor" RELATED [ChEBI] synonym: "RNA polymerase I inhibitors" RELATED [ChEBI] synonym: "RNA polymerase II inhibitor" RELATED [ChEBI] synonym: "RNA polymerase II inhibitors" RELATED [ChEBI] synonym: "RNA polymerase III inhibitor" RELATED [ChEBI] synonym: "RNA polymerase III inhibitors" RELATED [ChEBI] synonym: "RNA polymerase inhibitor" RELATED [ChEBI] synonym: "RNA polymerase inhibitors" RELATED [ChEBI] synonym: "RNA transcriptase inhibitor" RELATED [ChEBI] synonym: "RNA transcriptase inhibitors" RELATED [ChEBI] synonym: "transcriptase inhibitor" RELATED [ChEBI] synonym: "transcriptase inhibitors" RELATED [ChEBI] xref: Wikipedia:RNA_polymerase is_a: CHEBI:76815 ! EC 2.7.7.* (nucleotidyltransferase) inhibitor [Term] id: CHEBI:3745 name: clindamycin namespace: chebi_ontology alt_id: CHEBI:47331 def: "A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic." [] subset: 3_STAR synonym: "7(S)-Chloro-7-deoxylincomycin" RELATED [ChemIDplus] synonym: "7-CDL" RELATED [ChemIDplus] synonym: "Cleocin (TN)" RELATED [KEGG_DRUG] synonym: "Clindamycin" EXACT [KEGG_COMPOUND] synonym: "Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside" RELATED [ChemIDplus] xref: DrugBank:DB01190 xref: HMDB:HMDB0015321 xref: KEGG:C06914 xref: KEGG:C13684 xref: KEGG:D00277 xref: KEGG:D02132 xref: Wikipedia:Clindamycin is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:35275 ! S-glycosyl compound is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:46770 ! pyrrolidinecarboxamide is_a: CHEBI:72588 ! semisynthetic derivative relationship: has_functional_parent CHEBI:6472 ! lincomycin relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:3749 name: clofazimine namespace: chebi_ontology alt_id: CHEBI:355347 def: "3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients." [] subset: 3_STAR synonym: "(4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine" RELATED [ChEMBL] synonym: "3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine" RELATED [ChemIDplus] synonym: "3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin" RELATED [ChemIDplus] synonym: "N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine" RELATED [ChEMBL] xref: DrugBank:DB00845 xref: KEGG:C06915 xref: KEGG:D00278 xref: LINCS:LSM-5669 xref: Patent:US2948726 is_a: CHEBI:39201 ! phenazines is_a: CHEBI:83403 ! monochlorobenzenes relationship: RO:0000087 CHEBI:35475 ! has role non-steroidal anti-inflammatory drug relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug relationship: RO:0000087 CHEBI:37958 ! has role dye [Term] id: CHEBI:37527 name: acid namespace: chebi_ontology alt_id: CHEBI:13800 alt_id: CHEBI:13801 alt_id: CHEBI:22209 alt_id: CHEBI:2426 def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." [] subset: 3_STAR synonym: "Acid" EXACT [KEGG_COMPOUND] synonym: "acide" RELATED [IUPAC] synonym: "acido" RELATED [ChEBI] synonym: "acids" RELATED [ChEBI] synonym: "Saeure" RELATED [ChEBI] synonym: "Saeuren" RELATED [ChEBI] xref: KEGG:C00174 is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:37533 name: azo compound namespace: chebi_ontology def: "Derivatives of diazene with the general structure R-N=N-R'." [] subset: 3_STAR synonym: "azo compounds" RELATED [ChEBI] is_a: CHEBI:51143 ! nitrogen molecular entity relationship: BFO:0000051 CHEBI:30106 ! has part azo group relationship: has_parent_hydride CHEBI:30096 ! diazene [Term] id: CHEBI:37577 name: heteroatomic molecular entity namespace: chebi_ontology def: "A molecular entity consisting of two or more chemical elements." [] subset: 3_STAR synonym: "chemical compound" RELATED [ChEBI] synonym: "heteroatomic molecular entities" RELATED [ChEBI] is_a: CHEBI:36357 ! polyatomic entity [Term] id: CHEBI:37578 name: halide namespace: chebi_ontology def: "Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements." [] subset: 3_STAR synonym: "halides" RELATED [ChEBI] xref: Wikipedia:Halide is_a: CHEBI:24471 ! halogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:37622 name: carboxamide namespace: chebi_ontology alt_id: CHEBI:35354 alt_id: CHEBI:35355 def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." [] subset: 3_STAR synonym: "carboxamides" RELATED [ChEBI] synonym: "primary carboxamide" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: BFO:0000051 CHEBI:23004 ! has part carbamoyl group [Term] id: CHEBI:37624 name: L-glucose namespace: chebi_ontology subset: 3_STAR synonym: "L(-)-glucose" RELATED [ChemIDplus] is_a: CHEBI:17234 ! glucose [Term] id: CHEBI:37627 name: L-glucopyranose namespace: chebi_ontology def: "The L-enantiomer of glucopyranose." [] subset: 3_STAR synonym: "L-glucopyranose" EXACT [UniProt] synonym: "WURCS=2.0/1,1,0/[a1211h-1x_1-5]/1/" RELATED [GlyTouCan] xref: GlyTouCan:G16038XU is_a: CHEBI:37624 ! L-glucose is_a: CHEBI:37661 ! glucopyranose [Term] id: CHEBI:37630 name: alpha-L-glucose namespace: chebi_ontology def: "A L-glucopyranose with an alpha-configuration at the anomeric position." [] subset: 3_STAR synonym: "WURCS=2.0/1,1,0/[a1211h-1a_1-5]/1/" RELATED [GlyTouCan] xref: GlyTouCan:G15768VA is_a: CHEBI:37627 ! L-glucopyranose relationship: is_enantiomer_of CHEBI:17925 ! alpha-D-glucose [Term] id: CHEBI:37661 name: glucopyranose namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:17234 ! glucose [Term] id: CHEBI:37670 name: protease inhibitor namespace: chebi_ontology def: "A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases)." [] subset: 3_STAR synonym: "protease inhibitors" RELATED [ChEBI] xref: Wikipedia:Protease_inhibitor_(biology) is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor [Term] id: CHEBI:37699 name: protein kinase inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases." [] subset: 3_STAR synonym: "protein kinase inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:37734 name: phosphoric ester namespace: chebi_ontology alt_id: CHEBI:26019 subset: 1_STAR is_a: CHEBI:26079 ! phosphoric acid derivative is_a: CHEBI:35701 ! ester [Term] id: CHEBI:37806 name: penicillanic acid namespace: chebi_ontology def: "A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration." [] subset: 3_STAR synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "penicillanic acid" EXACT [ChemIDplus] is_a: CHEBI:25865 ! penicillanic acids [Term] id: CHEBI:37826 name: sulfuric acid derivative namespace: chebi_ontology subset: 3_STAR synonym: "sulfuric acid derivative" EXACT [ChEBI] synonym: "sulfuric acid derivatives" RELATED [ChEBI] is_a: CHEBI:33424 ! sulfur oxoacid derivative relationship: has_functional_parent CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:37838 name: carboacyl group namespace: chebi_ontology def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." [] subset: 3_STAR synonym: "carboxylic acyl groups" RELATED [IUPAC] is_a: CHEBI:22221 ! acyl group relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid [Term] id: CHEBI:37848 name: plant hormone namespace: chebi_ontology alt_id: CHEBI:26158 def: "A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds." [] subset: 3_STAR synonym: "phytohormone" RELATED [ChEBI] synonym: "phytohormones" RELATED [ChEBI] synonym: "plant growth factor" RELATED [ChEBI] synonym: "plant growth factors" RELATED [ChEBI] synonym: "plant growth hormone" RELATED [ChEBI] synonym: "plant growth hormones" RELATED [ChEBI] synonym: "plant hormones" RELATED [ChEBI] xref: Wikipedia:Phytohormone is_a: CHEBI:24621 ! hormone is_a: CHEBI:26155 ! plant growth regulator [Term] id: CHEBI:37852 name: organoammonium sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "organoammonium sulfates" RELATED [ChEBI] is_a: CHEBI:46850 ! organoammonium salt is_a: CHEBI:51337 ! organic sulfate salt [Term] id: CHEBI:37912 name: hydroxycoumarin namespace: chebi_ontology alt_id: CHEBI:24691 alt_id: CHEBI:24692 def: "Any coumarin carrying at least one hydroxy substituent." [] subset: 3_STAR synonym: "hydroxycoumarins" RELATED [ChEBI] is_a: CHEBI:23403 ! coumarins [Term] id: CHEBI:37943 name: colistin namespace: chebi_ontology alt_id: CHEBI:34651 alt_id: CHEBI:472593 alt_id: CHEBI:560465 alt_id: CHEBI:566816 alt_id: CHEBI:596826 alt_id: CHEBI:597111 alt_id: CHEBI:600596 alt_id: CHEBI:659853 def: "A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa." [] subset: 3_STAR synonym: "Colistin" EXACT [ChEMBL] synonym: "polymyxin E" RELATED [ChemIDplus] xref: DrugBank:DB00803 xref: KEGG:C13768 xref: KEGG:D02138 is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:59062 ! polymyxin relationship: BFO:0000051 CHEBI:59064 ! has part colistin A relationship: BFO:0000051 CHEBI:59673 ! has part colistin B relationship: RO:0000087 CHEBI:50909 ! has role nephrotoxic agent [Term] id: CHEBI:37948 name: oxaspiro compound namespace: chebi_ontology def: "A spiro compound in which at least one of the cyclic components is an oxygen heterocyle." [] subset: 3_STAR synonym: "oxaspiro compounds" RELATED [ChEBI] is_a: CHEBI:33599 ! spiro compound [Term] id: CHEBI:37958 name: dye namespace: chebi_ontology subset: 3_STAR synonym: "colorante" RELATED [ChEBI] synonym: "colorantes" RELATED [ChEBI] synonym: "dyes" RELATED [ChEBI] synonym: "Farbstoff" RELATED [ChEBI] synonym: "Farbstoffe" RELATED [ChEBI] synonym: "teinture" RELATED [ChEBI] synonym: "teintures" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:38012 name: aminoglycoside sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycoside sulfate salts" RELATED [ChEBI] is_a: CHEBI:37852 ! organoammonium sulfate salt [Term] id: CHEBI:38032 name: carbotricyclic compound namespace: chebi_ontology def: "A carbopolyclic compound comprising of three carbocyclic rings." [] subset: 3_STAR synonym: "carbotricyclic compounds" RELATED [ChEBI] is_a: CHEBI:35294 ! carbopolycyclic compound is_a: CHEBI:51959 ! organic tricyclic compound [Term] id: CHEBI:38068 name: antimalarial namespace: chebi_ontology def: "A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human." [] subset: 3_STAR synonym: "antimalarials" RELATED [ChEBI] is_a: CHEBI:64915 ! antiplasmodial drug [Term] id: CHEBI:38070 name: anti-arrhythmia drug namespace: chebi_ontology def: "A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres." [] subset: 3_STAR synonym: "anti-arrhythmia agent" RELATED [ChEBI] synonym: "antiarrhythmic agent" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug [Term] id: CHEBI:38099 name: thiadiazoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound namespace: chebi_ontology def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." [] subset: 3_STAR synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI] synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38102 name: triazines namespace: chebi_ontology def: "Compounds based on a triazine skeleton." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:50893 ! azaarene [Term] id: CHEBI:38104 name: oxacycle namespace: chebi_ontology def: "Any organic heterocyclic compound containing at least one ring oxygen atom." [] subset: 3_STAR synonym: "heterocyclic organooxygen compounds" RELATED [ChEBI] synonym: "organooxygen heterocyclic compounds" RELATED [ChEBI] synonym: "oxacycles" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:38106 name: organosulfur heterocyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "heterocyclic organosulfur compounds" RELATED [ChEBI] synonym: "organosulfur heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:38119 name: brassinin namespace: chebi_ontology subset: 3_STAR synonym: "Brassinine" RELATED [ChemIDplus] synonym: "methyl (1H-indol-3-ylmethyl)dithiocarbamate" RELATED [IUPAC] is_a: CHEBI:24797 ! indole phytoalexin is_a: CHEBI:38129 ! dithiocarbamic ester [Term] id: CHEBI:38127 name: thiocarbamic ester namespace: chebi_ontology def: "Any organonitrogen compound with formula RS-C(=X)NH2 where X = O (monothiocarbamic esters) or S (dithiocarbamic esters), or their N-substituted derivatives." [] subset: 3_STAR synonym: "thiocarbamate" RELATED [ChEBI] synonym: "thiocarbamates" RELATED [ChEBI] synonym: "thiocarbamic ester" EXACT [ChEBI] is_a: CHEBI:26959 ! thiocarboxylic ester is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38129 name: dithiocarbamic ester namespace: chebi_ontology def: "Any ester derived from a member of the class of dithiocarbamic acids by formal replacement of the -SH group by -SR, where R is an organyl group." [] subset: 3_STAR synonym: "carbamodithioates" RELATED [ChEBI] synonym: "carbamodithioic esters" RELATED [ChEBI] synonym: "dithiocarbamic ester" EXACT [ChEBI] synonym: "dithiocarbamoates" RELATED [ChEBI] is_a: CHEBI:38127 ! thiocarbamic ester [Term] id: CHEBI:38131 name: lactol namespace: chebi_ontology def: "Cyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues." [] subset: 3_STAR synonym: "lactol" EXACT [IUPAC] synonym: "lactols" RELATED [ChEBI] xref: Wikipedia:Lactol is_a: CHEBI:5653 ! hemiacetal [Term] id: CHEBI:38161 name: chelator namespace: chebi_ontology alt_id: CHEBI:23090 alt_id: CHEBI:3585 alt_id: CHEBI:6789 def: "A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate." [] subset: 3_STAR synonym: "Chelating agent" RELATED [KEGG_COMPOUND] synonym: "chelating agents" RELATED [ChEBI] synonym: "chelators" RELATED [ChEBI] synonym: "complexon" RELATED [ChEBI] synonym: "Metal chelator" RELATED [KEGG_COMPOUND] xref: KEGG:C00917 xref: KEGG:C02169 is_a: CHEBI:52214 ! ligand [Term] id: CHEBI:38163 name: organic heterotetracyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic heterotetracyclic compounds" RELATED [ChEBI] is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:38164 name: organic heteropentacyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic heteropentacyclic compounds" RELATED [ChEBI] is_a: CHEBI:38166 ! organic heteropolycyclic compound [Term] id: CHEBI:38166 name: organic heteropolycyclic compound namespace: chebi_ontology alt_id: CHEBI:25429 alt_id: CHEBI:38075 subset: 3_STAR synonym: "organic heteropolycyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33671 ! heteropolycyclic compound [Term] id: CHEBI:38179 name: monocyclic heteroarene namespace: chebi_ontology subset: 3_STAR synonym: "monocyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene [Term] id: CHEBI:38180 name: polycyclic heteroarene namespace: chebi_ontology subset: 3_STAR synonym: "polycyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene [Term] id: CHEBI:38181 name: pyridinemonocarboxylate namespace: chebi_ontology def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of a pyridinemonocarboxylic acid. A 'closed class'." [] subset: 3_STAR synonym: "pyridinemonocarboxylates" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:26420 ! pyridinemonocarboxylic acid [Term] id: CHEBI:38186 name: isonicotinate namespace: chebi_ontology def: "A pyridinemonocarboxylate resulting from the deprotonation of the carboxy group of isonicotinic acid." [] subset: 3_STAR synonym: "4-picolinate" RELATED [MetaCyc] synonym: "4-pyridinecarboxylate" RELATED [MetaCyc] synonym: "gamma-picolinate" RELATED [MetaCyc] synonym: "isonicotinate" EXACT [UniProt] xref: MetaCyc:CPD-13335 is_a: CHEBI:38181 ! pyridinemonocarboxylate relationship: is_conjugate_base_of CHEBI:6032 ! isonicotinic acid [Term] id: CHEBI:38215 name: calcium channel blocker namespace: chebi_ontology def: "One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools." [] subset: 3_STAR synonym: "calcium channel antagonist" RELATED [ChEBI] synonym: "calcium channel antagonists" RELATED [ChEBI] synonym: "calcium channel blockers" RELATED [ChEBI] is_a: CHEBI:38808 ! calcium channel modulator is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:38216 name: 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25471 ! naphthalenemonosulfonate relationship: is_conjugate_base_of CHEBI:38217 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) [Term] id: CHEBI:38217 name: 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid) namespace: chebi_ontology alt_id: CHEBI:291121 subset: 3_STAR synonym: "congo red" RELATED [ChEMBL] is_a: CHEBI:36336 ! naphthalenesulfonic acid relationship: is_conjugate_acid_of CHEBI:38216 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) [Term] id: CHEBI:38218 name: isophthalonitrile namespace: chebi_ontology subset: 3_STAR synonym: "1,3-Benzenedicarbonitrile" RELATED [NIST_Chemistry_WebBook] synonym: "1,3-Dicyanobenzene" RELATED [ChemIDplus] synonym: "3-Cyanobenzonitrile" RELATED [ChemIDplus] synonym: "IPN" RELATED [NIST_Chemistry_WebBook] synonym: "Isophthalodinitrile" RELATED [NIST_Chemistry_WebBook] synonym: "m-Dicyanobenzene" RELATED [ChemIDplus] is_a: CHEBI:18379 ! nitrile relationship: has_functional_parent CHEBI:30802 ! isophthalic acid [Term] id: CHEBI:38231 name: phytotoxin namespace: chebi_ontology def: "Any toxin produced by a plant." [] subset: 3_STAR synonym: "phytotoxins" RELATED [ChEBI] is_a: CHEBI:27026 ! toxin is_a: CHEBI:76924 ! plant metabolite [Term] id: CHEBI:38260 name: pyrrolidines namespace: chebi_ontology alt_id: CHEBI:26922 alt_id: CHEBI:38191 def: "Any of a class of heterocyclic amines having a saturated five-membered ring." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38261 name: imidazolidines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38304 ! diazolidine [Term] id: CHEBI:38295 name: azabicycloalkane namespace: chebi_ontology subset: 3_STAR synonym: "azabicycloalkanes" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38298 name: benzodioxoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:38304 name: diazolidine namespace: chebi_ontology subset: 3_STAR synonym: "diazolidines" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38311 name: cephem namespace: chebi_ontology subset: 3_STAR synonym: "cephems" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:27933 ! beta-lactam antibiotic is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:38313 name: diazines namespace: chebi_ontology def: "Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure)." [] subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:38314 name: pyrazines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38313 ! diazines [Term] id: CHEBI:38329 name: oxazolidines namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:38337 name: pyrimidone namespace: chebi_ontology def: "A pyrimidine carrying one or more oxo substituents." [] subset: 3_STAR synonym: "pyrimidones" RELATED [ChEBI] is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:38338 name: aminopyrimidine namespace: chebi_ontology def: "A member of the class of pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives." [] subset: 3_STAR synonym: "aminopyrimidines" RELATED [ChEBI] is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:38418 name: 1,3-thiazoles namespace: chebi_ontology alt_id: CHEBI:26949 alt_id: CHEBI:38417 subset: 3_STAR synonym: "1,3-thiazoles" EXACT [ChEBI] is_a: CHEBI:48901 ! thiazoles [Term] id: CHEBI:38443 name: 1-benzopyran namespace: chebi_ontology subset: 3_STAR synonym: "1-benzopyrans" RELATED [ChEBI] is_a: CHEBI:22727 ! benzopyran [Term] id: CHEBI:38445 name: chromenone namespace: chebi_ontology subset: 3_STAR synonym: "chromenones" RELATED [ChEBI] is_a: CHEBI:23232 ! chromenes [Term] id: CHEBI:38496 name: electron-transport chain inhibitor namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:38497 name: respiratory-chain inhibitor namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:38496 ! electron-transport chain inhibitor [Term] id: CHEBI:38498 name: mitochondrial NADH:ubiquinone reductase inhibitor namespace: chebi_ontology subset: 3_STAR synonym: "mitochondrial complex I inhibitor" RELATED [ChEBI] synonym: "mitochondrial complex I inhibitors" RELATED [ChEBI] synonym: "mitochondrial NADH dehydrogenase inhibitor" RELATED [ChEBI] is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:38503 ! EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor [Term] id: CHEBI:38499 name: mitochondrial cytochrome-bc1 complex inhibitor namespace: chebi_ontology subset: 3_STAR synonym: "mitochondrial complex III inhibitor" RELATED [ChEBI] synonym: "mitochondrial complex III inhibitors" RELATED [ChEBI] is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:38502 ! cytochrome-bc1 complex inhibitor [Term] id: CHEBI:38500 name: EC 1.9.3.1 (cytochrome c oxidase) inhibitor namespace: chebi_ontology alt_id: CHEBI:38501 alt_id: CHEBI:62966 def: "An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome c oxidase (EC 1.9.3.1)." [] subset: 3_STAR synonym: "CcO inhibitor" RELATED [ChEBI] synonym: "complex IV (mitochondrial electron transport) inhibitor" RELATED [ChEBI] synonym: "complex IV (mitochondrial electron transport) inhibitors" RELATED [ChEBI] synonym: "cytochrome a3 inhibitor" RELATED [ChEBI] synonym: "cytochrome a3 inhibitors" RELATED [ChEBI] synonym: "cytochrome aa3 inhibitor" RELATED [ChEBI] synonym: "cytochrome aa3 inhibitors" RELATED [ChEBI] synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitor" RELATED [ChEBI] synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitors" RELATED [ChEBI] synonym: "cytochrome c oxidase inhibitor" RELATED [ChEBI] synonym: "cytochrome c oxidase inhibitors" RELATED [ChEBI] synonym: "cytochrome oxidase inhibitor" RELATED [ChEBI] synonym: "cytochrome oxidase inhibitors" RELATED [ChEBI] synonym: "cytochrome-c oxidase inhibitor" RELATED [ChEBI] synonym: "cytochrome-c oxidase inhibitors" RELATED [ChEBI] synonym: "EC 1.9.3.1 (cytochrome c oxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.3.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.9.3.1 inhibitors" RELATED [ChEBI] synonym: "ferrocytochrome c oxidase inhibitor" RELATED [ChEBI] synonym: "ferrocytochrome c oxidase inhibitors" RELATED [ChEBI] synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitor" RELATED [ChEBI] synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitors" RELATED [ChEBI] synonym: "indophenol oxidase inhibitor" RELATED [ChEBI] synonym: "indophenol oxidase inhibitors" RELATED [ChEBI] synonym: "indophenolase inhibitor" RELATED [ChEBI] synonym: "indophenolase inhibitors" RELATED [ChEBI] synonym: "mitochondrial complex IV inhibitor" RELATED [ChEBI] synonym: "mitochondrial complex IV inhibitors" RELATED [ChEBI] synonym: "mitochondrial cytochrome-c oxidase inhibitors" RELATED [ChEBI] synonym: "NADH cytochrome c oxidase inhibitor" RELATED [ChEBI] synonym: "NADH cytochrome c oxidase inhibitors" RELATED [ChEBI] synonym: "Warburg's respiratory enzyme inhibitor" RELATED [ChEBI] synonym: "Warburg's respiratory enzyme inhibitors" RELATED [ChEBI] xref: Wikipedia:Cytochrome_c_oxidase is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor is_a: CHEBI:76870 ! EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor [Term] id: CHEBI:38502 name: cytochrome-bc1 complex inhibitor namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:38497 ! respiratory-chain inhibitor [Term] id: CHEBI:38503 name: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor namespace: chebi_ontology def: "A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (H(+)-translocating), EC 1.6.5.3." [] subset: 3_STAR synonym: "coenzyme Q reductase" RELATED [ChEBI] synonym: "complex 1 dehydrogenase inhibitor" RELATED [ChEBI] synonym: "complex I (electron transport chain) inhibitors" RELATED [ChEBI] synonym: "complex I (mitochondrial electron transport) inhibitors" RELATED [ChEBI] synonym: "complex I (NADH:Q1 oxidoreductase) inhibitors" RELATED [ChEBI] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "DPNH-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "DPNH-ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors" RELATED [ChEBI] synonym: "EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors" RELATED [ChEBI] synonym: "EC 1.6.5.3 inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.3 inhibitors" RELATED [ChEBI] synonym: "electron transfer complex I inhibitor" RELATED [ChEBI] synonym: "electron transfer complex I inhibitors" RELATED [ChEBI] synonym: "mitochondrial electron transport complex 1 inhibitor" RELATED [ChEBI] synonym: "mitochondrial electron transport complex I inhibitor" RELATED [ChEBI] synonym: "mitochondrial electron transport complex I inhibitors" RELATED [ChEBI] synonym: "NADH coenzyme Q1 reductase inhibitor" RELATED [ChEBI] synonym: "NADH coenzyme Q1 reductase inhibitors" RELATED [ChEBI] synonym: "NADH dehydrogenase (ubiquinone) inhibitor" RELATED [ChEBI] synonym: "NADH dehydrogenase (ubiquinone) inhibitors" RELATED [ChEBI] synonym: "NADH-coenzyme Q oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "NADH-coenzyme Q reductase inhibitors" RELATED [ChEBI] synonym: "NADH-CoQ oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH-CoQ oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH-CoQ reductase inhibitor" RELATED [ChEBI] synonym: "NADH-CoQ reductase inhibitors" RELATED [ChEBI] synonym: "NADH-Q6 oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH-ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone reductase inhibitors" RELATED [ChEBI] synonym: "NADH-ubiquinone-1 reductase inhibitor" RELATED [ChEBI] synonym: "NADH-ubiquinone-1 reductase inhibitors" RELATED [ChEBI] synonym: "NADH2 dehydrogenase (ubiquinone) inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone oxidoreductase complex inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase (H(+)-translocating) inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase (H(+)-translocating) inhibitors" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase (H+-translocating) inhibitor" RELATED [ChEBI] synonym: "NADH:ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor" RELATED [ChEBI] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors" RELATED [ChEBI] synonym: "type 1 dehydrogenase inhibitor" RELATED [ChEBI] synonym: "type 1 dehydrogenase inhibitors" RELATED [ChEBI] synonym: "ubiquinone reductase inhibitor" RELATED [ChEBI] synonym: "ubiquinone reductase inhibitors" RELATED [ChEBI] xref: Wikipedia:NADH_dehydrogenase_(ubiquinone) is_a: CHEBI:38497 ! respiratory-chain inhibitor is_a: CHEBI:76866 ! EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor [Term] id: CHEBI:38532 name: hydrazone namespace: chebi_ontology def: "Compounds having the structure R2C=NNR2, formally derived from aldehydes or ketones by replacing =O by =NNH2 (or substituted analogues)." [] subset: 3_STAR synonym: "hydrazones" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:38582 name: difluorobenzene namespace: chebi_ontology def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying two fluorine atoms." [] subset: 3_STAR synonym: "Difluorbenzol" RELATED [ChEBI] synonym: "difluorobenzenes" RELATED [ChEBI] is_a: CHEBI:35496 ! fluorobenzenes [Term] id: CHEBI:38584 name: 1,3-difluorobenzene namespace: chebi_ontology def: "A difluorobenzene carrying fluoro groups at positions 1 and 3." [] subset: 3_STAR synonym: "1,3-Difluorbenzol" RELATED [ChEBI] synonym: "m-difluorobenzene" RELATED [ChemIDplus] synonym: "meta-difluorobenzene" RELATED [NIST_Chemistry_WebBook] xref: Patent:CN101607874 xref: Patent:CN1634895 xref: Patent:CN1765887 is_a: CHEBI:38582 ! difluorobenzene [Term] id: CHEBI:38597 name: triazole namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:35555 ! mancude organic heteromonocyclic parent is_a: CHEBI:35727 ! triazoles [Term] id: CHEBI:38623 name: EC 1.4.3.4 (monoamine oxidase) inhibitor namespace: chebi_ontology def: "An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4)." [] subset: 3_STAR synonym: "adrenalin oxidase inhibitor" RELATED [ChEBI] synonym: "adrenalin oxidase inhibitors" RELATED [ChEBI] synonym: "adrenaline oxidase inhibitor" RELATED [ChEBI] synonym: "adrenaline oxidase inhibitors" RELATED [ChEBI] synonym: "amine oxidase (flavin-containing) inhibitor" RELATED [ChEBI] synonym: "amine oxidase (flavin-containing) inhibitors" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) inhibitor" RELATED [ChEBI] synonym: "amine:oxygen oxidoreductase (deaminating) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.3.4 (monoamine oxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.3.4 inhibitor" RELATED [ChEBI] synonym: "EC 1.4.3.4 inhibitors" RELATED [ChEBI] synonym: "epinephrine oxidase inhibitor" RELATED [ChEBI] synonym: "epinephrine oxidase inhibitors" RELATED [ChEBI] synonym: "MAO A inhibitor" RELATED [ChEBI] synonym: "MAO A inhibitors" RELATED [ChEBI] synonym: "MAO B inhibitor" RELATED [ChEBI] synonym: "MAO B inhibitors" RELATED [ChEBI] synonym: "MAO inhibitor" RELATED [ChEBI] synonym: "MAO inhibitors" RELATED [ChEBI] synonym: "MAO-A inhibitor" RELATED [ChEBI] synonym: "MAO-A inhibitors" RELATED [ChEBI] synonym: "MAO-B inhibitor" RELATED [ChEBI] synonym: "MAO-B inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase (EC 1.4.3.4) inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase (EC 1.4.3.4) inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase A inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase A inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase B inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase B inhibitors" RELATED [ChEBI] synonym: "monoamine oxidase inhibitor" RELATED [ChEBI] synonym: "monoamine oxidase inhibitors" RELATED [ChEBI] synonym: "monoamine:O2 oxidoreductase (deaminating) inhibitor" RELATED [ChEBI] synonym: "monoamine:O2 oxidoreductase (deaminating) inhibitors" RELATED [ChEBI] synonym: "serotonin deaminase inhibitor" RELATED [ChEBI] synonym: "serotonin deaminase inhibitors" RELATED [ChEBI] synonym: "tyraminase inhibitor" RELATED [ChEBI] synonym: "tyraminase inhibitors" RELATED [ChEBI] synonym: "tyramine oxidase inhibitor" RELATED [ChEBI] synonym: "tyramine oxidase inhibitors" RELATED [ChEBI] xref: Wikipedia:Monoamine_oxidase_inhibitor is_a: CHEBI:76861 ! EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor [Term] id: CHEBI:38632 name: membrane transport modulator namespace: chebi_ontology def: "Any agent that affects the transport of molecular entities across a biological membrane." [] subset: 3_STAR synonym: "membrane transport modulators" RELATED [ChEBI] is_a: CHEBI:52208 ! biophysical role [Term] id: CHEBI:38700 name: organic sodium salt namespace: chebi_ontology subset: 3_STAR synonym: "organic sodium salt" EXACT [ChEBI] synonym: "organic sodium salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:38702 name: inorganic sodium salt namespace: chebi_ontology subset: 3_STAR synonym: "inorganic sodium salts" RELATED [ChEBI] is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:26714 ! sodium salt [Term] id: CHEBI:38716 name: carboxylic acid dianion namespace: chebi_ontology def: "Any dianion containing at least one carboxy group." [] subset: 3_STAR synonym: "carboxylic acid dianion" EXACT [ChEBI] synonym: "carboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:38773 name: quinolinemonocarboxylate namespace: chebi_ontology def: "A monocarboxylic acid anion that is the monoanion obtained by the deprotonation of the carboxy group attached to the quinoline skeleton" [] subset: 3_STAR synonym: "quinolinemonocarboxylates" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:26512 ! quinolinemonocarboxylic acid [Term] id: CHEBI:38785 name: morpholines namespace: chebi_ontology def: "Any compound containing morpholine as part of its structure." [] subset: 3_STAR is_a: CHEBI:46952 ! oxazinane [Term] id: CHEBI:38808 name: calcium channel modulator namespace: chebi_ontology def: "A membrane transport modulator that is able to regulate intracellular calcium levels." [] subset: 3_STAR synonym: "calcium channel modulators" RELATED [ChEBI] is_a: CHEBI:38632 ! membrane transport modulator [Term] id: CHEBI:38922 name: dibenzofurans namespace: chebi_ontology def: "Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof." [] subset: 3_STAR is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:39141 name: Bronsted acid namespace: chebi_ontology def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." [] subset: 3_STAR synonym: "acide de Bronsted" RELATED [IUPAC] synonym: "Bronsted-Saeure" RELATED [ChEBI] synonym: "donneur d'hydron" RELATED [IUPAC] synonym: "hydron donor" RELATED [IUPAC] is_a: CHEBI:17891 ! donor is_a: CHEBI:37527 ! acid [Term] id: CHEBI:39142 name: Bronsted base namespace: chebi_ontology def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." [] subset: 3_STAR synonym: "accepteur d'hydron" RELATED [IUPAC] synonym: "base de Bronsted" RELATED [IUPAC] synonym: "Bronsted-Base" RELATED [ChEBI] synonym: "hydron acceptor" RELATED [IUPAC] is_a: CHEBI:15339 ! acceptor is_a: CHEBI:22695 ! base [Term] id: CHEBI:39144 name: Lewis base namespace: chebi_ontology def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." [] subset: 3_STAR synonym: "base de Lewis" RELATED [IUPAC] synonym: "donneur d'une paire d'electrons" RELATED [ChEBI] synonym: "electron donor" RELATED [ChEBI] synonym: "Lewis-Base" RELATED [ChEBI] is_a: CHEBI:17891 ! donor is_a: CHEBI:22695 ! base [Term] id: CHEBI:39146 name: trichostatin namespace: chebi_ontology subset: 3_STAR synonym: "trichostatin" EXACT [ChEBI] synonym: "trichostatins" RELATED [ChEBI] is_a: CHEBI:49319 ! carbocyclic antibiotic [Term] id: CHEBI:39157 name: trichostatic acid namespace: chebi_ontology subset: 3_STAR synonym: "(+-)-7-(4-(dimethylamino)phenyl)-4,6-dimethyl-7-oxo-2,4-heptadienoic acid" RELATED [ChemIDplus] synonym: "trichostatic acid" EXACT [ChemIDplus] is_a: CHEBI:35983 ! 7-oxo monocarboxylic acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid [Term] id: CHEBI:39158 name: (R)-trichostatic acid namespace: chebi_ontology subset: 3_STAR synonym: "(+)-trichostatic acid" RELATED [ChEBI] synonym: "(+)-Trichostatsaeure" RELATED [ChEBI] is_a: CHEBI:39157 ! trichostatic acid relationship: is_enantiomer_of CHEBI:39159 ! (S)-trichostatic acid [Term] id: CHEBI:39159 name: (S)-trichostatic acid namespace: chebi_ontology subset: 3_STAR synonym: "(-)-trichostatic acid" RELATED [ChEBI] synonym: "(-)-Trichostatsaeure" RELATED [ChEBI] is_a: CHEBI:39157 ! trichostatic acid relationship: is_enantiomer_of CHEBI:39158 ! (R)-trichostatic acid [Term] id: CHEBI:39201 name: phenazines namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives." [] subset: 3_STAR is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:39208 name: antibiotic insecticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24852 ! insecticide is_a: CHEBI:39215 ! antibiotic pesticide [Term] id: CHEBI:39209 name: macrolide insecticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39221 ! macrolide pesticide relationship: RO:0000087 CHEBI:39208 ! has role antibiotic insecticide [Term] id: CHEBI:39213 name: avermectin insecticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39209 ! macrolide insecticide is_a: CHEBI:39220 ! avermectin pesticide [Term] id: CHEBI:39214 name: abamectin namespace: chebi_ontology def: "Mixture of 80% avermectin B1a and 20% avermectin B1b." [] subset: 3_STAR synonym: "Abamectin" EXACT [ChemIDplus] synonym: "Agri-Mek" RELATED [ChemIDplus] synonym: "avermectin B1" RELATED [ChemIDplus] synonym: "Avid" RELATED [ChemIDplus] synonym: "MK 936" RELATED [ChemIDplus] synonym: "Zephyr" RELATED [ChemIDplus] is_a: CHEBI:39213 ! avermectin insecticide is_a: CHEBI:39219 ! avermectin acaricide is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:29534 ! has part avermectin B1a relationship: BFO:0000051 CHEBI:29537 ! has part avermectin B1b relationship: RO:0000087 CHEBI:39217 ! has role antibiotic nematicide [Term] id: CHEBI:39215 name: antibiotic pesticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25944 ! pesticide is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:39216 name: antibiotic acaricide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:22153 ! acaricide is_a: CHEBI:39215 ! antibiotic pesticide [Term] id: CHEBI:39217 name: antibiotic nematicide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25491 ! nematicide is_a: CHEBI:39215 ! antibiotic pesticide [Term] id: CHEBI:39218 name: macrolide acaricide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39221 ! macrolide pesticide relationship: RO:0000087 CHEBI:39216 ! has role antibiotic acaricide [Term] id: CHEBI:39219 name: avermectin acaricide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39218 ! macrolide acaricide is_a: CHEBI:39220 ! avermectin pesticide [Term] id: CHEBI:39220 name: avermectin pesticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:39221 ! macrolide pesticide [Term] id: CHEBI:39221 name: macrolide pesticide namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25105 ! macrolide antibiotic [Term] id: CHEBI:39230 name: emamectin namespace: chebi_ontology def: "A mixture of emamectin B1a (major component) and emamectin B1b (minor component)." [] subset: 3_STAR synonym: "(4''R)- 4''-deoxy-4''-(methylamino)avermectin B1" RELATED [ChemIDplus] synonym: "4''-epi-methylamino-4''-deoxyavermectin B1" RELATED [ChemIDplus] synonym: "emamectin" EXACT [ChemIDplus] is_a: CHEBI:39213 ! avermectin insecticide relationship: BFO:0000051 CHEBI:39231 ! has part emamectin B1a relationship: BFO:0000051 CHEBI:39232 ! has part emamectin B1b [Term] id: CHEBI:39231 name: emamectin B1a namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:50346 ! emamectins [Term] id: CHEBI:39232 name: emamectin B1b namespace: chebi_ontology subset: 3_STAR synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside" RELATED [IUPAC] is_a: CHEBI:50346 ! emamectins [Term] id: CHEBI:39270 name: naphthofuran namespace: chebi_ontology subset: 3_STAR synonym: "naphthofurans" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:39317 name: growth regulator namespace: chebi_ontology def: "Any chemical substance that inhibits the life-cycle of an organism." [] subset: 3_STAR synonym: "growth regulators" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:39410 name: 1,2,4-triazines namespace: chebi_ontology def: "Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure." [] subset: 3_STAR is_a: CHEBI:38102 ! triazines [Term] id: CHEBI:39418 name: straight-chain saturated fatty acid namespace: chebi_ontology def: "Any saturated fatty acid lacking a side-chain." [] subset: 3_STAR synonym: "straight-chain saturated fatty acid" EXACT [ChEBI] synonym: "straight-chain saturated fatty acids" RELATED [ChEBI] is_a: CHEBI:26607 ! saturated fatty acid is_a: CHEBI:59202 ! straight-chain fatty acid relationship: is_conjugate_acid_of CHEBI:58954 ! straight-chain saturated fatty acid anion [Term] id: CHEBI:39430 name: dioxolane namespace: chebi_ontology subset: 3_STAR synonym: "dioxolanes" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:39442 name: fluorescent probe namespace: chebi_ontology def: "A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy." [] subset: 3_STAR is_a: CHEBI:50406 ! probe [Term] id: CHEBI:39446 name: pyrimidine ribonucleosides namespace: chebi_ontology alt_id: CHEBI:13784 alt_id: CHEBI:26445 alt_id: CHEBI:7263 subset: 3_STAR is_a: CHEBI:18254 ! ribonucleoside is_a: CHEBI:26440 ! pyrimidine nucleoside [Term] id: CHEBI:39447 name: pyrimidines namespace: chebi_ontology alt_id: CHEBI:13681 alt_id: CHEBI:26448 def: "Any compound having a pyrimidine as part of its structure." [] subset: 3_STAR is_a: CHEBI:38313 ! diazines [Term] id: CHEBI:39474 name: polyazaalkane namespace: chebi_ontology def: "Any azaalkane in which two or more carbons in the chain are replaced by nitrogen." [] subset: 3_STAR synonym: "polyazaalkanes" RELATED [ChEBI] is_a: CHEBI:46686 ! azaalkane is_a: CHEBI:88061 ! polyamine [Term] id: CHEBI:39745 name: dihydrogenphosphate namespace: chebi_ontology alt_id: CHEBI:29137 alt_id: CHEBI:39739 def: "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." [] subset: 3_STAR synonym: "[PO2(OH)2](-)" RELATED [IUPAC] synonym: "DIHYDROGENPHOSPHATE ION" RELATED [PDBeChem] synonym: "H2PO4(-)" RELATED [IUPAC] xref: DrugBank:DB02831 xref: PDBeChem:2HP is_a: CHEBI:35780 ! phosphate ion is_a: CHEBI:79389 ! monovalent inorganic anion relationship: is_conjugate_acid_of CHEBI:43474 ! hydrogenphosphate [Term] id: CHEBI:3992 name: cyclic ketone namespace: chebi_ontology subset: 3_STAR synonym: "Cyclic ketone" EXACT [KEGG_COMPOUND] xref: KEGG:C02019 is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:40009 name: D-cycloserine namespace: chebi_ontology alt_id: CHEBI:4030 def: "A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis)." [] subset: 3_STAR synonym: "(+)-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "(+)-cycloserine" RELATED [ChEBI] synonym: "(R)-4-AMINO-ISOXAZOLIDIN-3-ONE" RELATED [PDBeChem] synonym: "alpha-Cycloserine" RELATED [NIST_Chemistry_WebBook] synonym: "cyclo-D-serine" RELATED [ChemIDplus] synonym: "D-(+)-cycloserine" RELATED [ChEBI] synonym: "D-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "D-4-amino-3-isoxazolidone" RELATED [ChemIDplus] synonym: "D-Cycloserine" EXACT [ChemIDplus, KEGG_COMPOUND] synonym: "DCS" RELATED [ChemIDplus] synonym: "orientomycin" RELATED [ChemIDplus] synonym: "PA 94" RELATED [ChemIDplus] synonym: "PA-94" RELATED [ChemIDplus] synonym: "Ro-1-9213" RELATED [ChemIDplus] xref: DrugBank:DB00260 xref: HMDB:HMDB0014405 xref: KEGG:D00877 xref: LINCS:LSM-5932 xref: MetaCyc:CPD-2482 xref: Patent:US2772280 xref: Patent:US2840565 xref: PDBeChem:4AX xref: Wikipedia:Cycloserine is_a: CHEBI:23503 ! 4-amino-1,2-oxazolidin-3-one is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic relationship: is_conjugate_base_of CHEBI:75929 ! D-cycloserine(1+) relationship: is_enantiomer_of CHEBI:75592 ! L-cycloserine relationship: is_tautomer_of CHEBI:74159 ! D-cycloserine zwitterion relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35221 ! has role antimetabolite relationship: RO:0000087 CHEBI:64571 ! has role NMDA receptor agonist [Term] id: CHEBI:4031 name: cyclosporin A namespace: chebi_ontology alt_id: CHEBI:63586 alt_id: CHEBI:91802 def: "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." [] subset: 3_STAR synonym: "(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)" RELATED [ChEBI] synonym: "1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]" RELATED [JCBN] synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" RELATED [ChEBI] synonym: "Antibiotic S 7481F1" RELATED [ChemIDplus] synonym: "Ciclosporin" RELATED [KEGG_COMPOUND] synonym: "Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)" RELATED [ChemIDplus] synonym: "Cyclosporin A" EXACT [KEGG_COMPOUND] synonym: "cyclosporin A" EXACT [UniProt] synonym: "Cyclosporine" RELATED [ChemIDplus, KEGG_COMPOUND] xref: Chemspider:4447449 xref: DrugBank:DB00091 xref: HMDB:HMDB0250682 xref: KEGG:C05086 xref: KEGG:D00184 xref: KNApSAcK:C00001517 xref: LINCS:LSM-1703 xref: MetaCyc:CPD-20532 xref: Patent:US4117118 xref: VSDB:1765 xref: Wikipedia:Ciclosporin is_a: CHEBI:24613 ! homodetic cyclic peptide relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:35842 ! has role antirheumatic drug relationship: RO:0000087 CHEBI:37153 ! has role EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor relationship: RO:0000087 CHEBI:49167 ! has role anti-asthmatic drug relationship: RO:0000087 CHEBI:50177 ! has role dermatologic drug relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent [Term] id: CHEBI:404903 name: ertapenem namespace: chebi_ontology alt_id: CHEBI:471574 def: "Meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract." [] subset: 3_STAR synonym: "(1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid" RELATED [ChEBI] synonym: "(4R,5S,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "ERTAPENEM" EXACT [ChEMBL] xref: DrugBank:DB00303 xref: KEGG:D07908 xref: Patent:US5478820 xref: Patent:WO9315078 xref: Wikipedia:Ertapenem is_a: CHEBI:46634 ! carbapenemcarboxylic acid is_a: CHEBI:46770 ! pyrrolidinecarboxamide relationship: is_conjugate_acid_of CHEBI:60071 ! ertapenem(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:40909 name: azoxystrobin namespace: chebi_ontology def: "An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture." [] subset: 3_STAR synonym: "(alphaE)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-alpha-(methoxymethylene) benzeneacetic acid methyl ester" RELATED [ChEBI] synonym: "methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylate" RELATED [ChEBI] xref: KEGG:C18558 xref: Patent:EP382375 xref: Patent:US5395837 xref: PDBeChem:AZO xref: PPDB:54 xref: Wikipedia:Azoxystrobin is_a: CHEBI:18379 ! nitrile is_a: CHEBI:47985 ! enol ether is_a: CHEBI:48535 ! aryloxypyrimidine is_a: CHEBI:86484 ! methoxyacrylate strobilurin antifungal agent relationship: RO:0000087 CHEBI:141153 ! has role quinone outside inhibitor relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:41032 name: 5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:81783 ! tricyclazole [Term] id: CHEBI:41275 name: 1H-benzimidazole namespace: chebi_ontology alt_id: CHEBI:3028 alt_id: CHEBI:41272 def: "The 1H-tautomer of benzimidazole." [] subset: 3_STAR synonym: "1,3-benzodiazole" RELATED [ChemIDplus] synonym: "1,3-diazaindene" RELATED [ChemIDplus] synonym: "azindole" RELATED [ChemIDplus] synonym: "BENZIMIDAZOLE" RELATED [PDBeChem] synonym: "Benzimidazole" RELATED [KEGG_COMPOUND] synonym: "benzimidazole" RELATED [IUPAC] synonym: "benzoglyoxaline" RELATED [ChemIDplus] synonym: "Hbim" RELATED [IUPAC] synonym: "Hbzim" RELATED [IUPAC] synonym: "o-benzimidazole" RELATED [NIST_Chemistry_WebBook] xref: DrugBank:DB02962 xref: KEGG:C02009 xref: MetaCyc:BENZIMIDAZOLE xref: PDBeChem:BZI xref: Wikipedia:Benzimidazole is_a: CHEBI:36622 ! benzimidazole is_a: CHEBI:38180 ! polycyclic heteroarene relationship: is_conjugate_acid_of CHEBI:33173 ! benzimidazolide relationship: is_tautomer_of CHEBI:36623 ! 4H-benzimidazole relationship: is_tautomer_of CHEBI:36639 ! 2H-benzimidazole relationship: is_tautomer_of CHEBI:36641 ! 3aH-benzimidazole [Term] id: CHEBI:41609 name: carbonate namespace: chebi_ontology alt_id: CHEBI:29201 alt_id: CHEBI:41605 subset: 3_STAR synonym: "[CO3](2-)" RELATED [IUPAC] synonym: "carbonate" EXACT [IUPAC] synonym: "CARBONATE ION" RELATED [PDBeChem] synonym: "CO3(2-)" RELATED [ChEBI] synonym: "Karbonat" RELATED [ChEBI] xref: PDBeChem:CO3 is_a: CHEBI:35604 ! carbon oxoanion relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate [Term] id: CHEBI:4167 name: D-glucopyranose namespace: chebi_ontology def: "A glucopyranose having D-configuration." [] subset: 3_STAR synonym: "D-Glc" RELATED [ChEBI] synonym: "D-Glcp" RELATED [ChEBI] synonym: "D-Glucose" RELATED [KEGG_COMPOUND] synonym: "D-glucose" RELATED [UniProt] synonym: "Dextrose" RELATED [KEGG_COMPOUND] synonym: "Glc-OH" RELATED [ChEBI] synonym: "Glucose" RELATED [KEGG_COMPOUND] synonym: "glucose" RELATED [ChEBI] synonym: "Grape sugar" RELATED [KEGG_COMPOUND] synonym: "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/" RELATED [GlyTouCan] xref: GlyGen:G15021LG xref: GlyTouCan:G15021LG xref: HMDB:HMDB0000122 xref: KEGG:C00031 xref: KEGG:D00009 xref: KNApSAcK:C00001122 xref: MetaCyc:D-Glucose xref: Wikipedia:Glucose is_a: CHEBI:17634 ! D-glucose is_a: CHEBI:37661 ! glucopyranose relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:417636 name: 4-\{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl\}-thiazol-2-yl-ammonium namespace: chebi_ontology subset: 2_STAR is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:33575 ! carboxylic acid relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:4194 name: D-hexose namespace: chebi_ontology def: "A hexose that has D-configuration at position 5." [] subset: 3_STAR synonym: "a D-hexose" RELATED [UniProt] synonym: "D-Hexose" EXACT [KEGG_COMPOUND] synonym: "D-hexoses" RELATED [ChEBI] xref: KEGG:C00738 is_a: CHEBI:18133 ! hexose [Term] id: CHEBI:41948 name: eflornithine namespace: chebi_ontology alt_id: CHEBI:41946 alt_id: CHEBI:4761 def: "A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2." [] subset: 3_STAR synonym: "alpha-(Difluoromethyl)-DL-ornithine" RELATED [DrugCentral] synonym: "ALPHA-DIFLUOROMETHYLORNITHINE" RELATED [PDBeChem] synonym: "alpha-difluoromethylornithine" RELATED [ChemIDplus] synonym: "DFMO" RELATED [ChemIDplus] synonym: "DL-Ornithine, 2-(difluoromethyl)-" RELATED [KEGG_COMPOUND] synonym: "Eflornithine" EXACT [KEGG_COMPOUND] xref: DrugBank:DB03856 xref: KEGG:C07997 xref: KEGG:D07883 xref: PDBeChem:DMO xref: Wikipedia:Eflornithine is_a: CHEBI:24068 ! fluoroamino acid is_a: CHEBI:33704 ! alpha-amino acid relationship: has_functional_parent CHEBI:18257 ! ornithine relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug [Term] id: CHEBI:42266 name: ethane namespace: chebi_ontology alt_id: CHEBI:23975 alt_id: CHEBI:42260 def: "An alkane comprising of two carbon atoms." [] subset: 3_STAR synonym: "Aethan" RELATED [ChEBI] synonym: "bimethyl" RELATED [NIST_Chemistry_WebBook] synonym: "C2H6" RELATED [ChEBI] synonym: "CH3-CH3" RELATED [IUPAC] synonym: "dimethyl" RELATED [NIST_Chemistry_WebBook] synonym: "Ethan" RELATED [ChEBI] synonym: "ETHANE" EXACT [PDBeChem] synonym: "ethane" EXACT [UniProt] synonym: "ethyl hydride" RELATED [NIST_Chemistry_WebBook] synonym: "methylmethane" RELATED [NIST_Chemistry_WebBook] synonym: "R-170" RELATED [ChEBI] xref: Wikipedia:Ethane is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:18310 ! alkane relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:78433 ! has role refrigerant [Term] id: CHEBI:42355 name: erythromycin A namespace: chebi_ontology alt_id: CHEBI:112506 alt_id: CHEBI:23950 alt_id: CHEBI:28672 alt_id: CHEBI:42352 alt_id: CHEBI:4841 alt_id: CHEBI:4843 def: "An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively." [] subset: 3_STAR synonym: "(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione" RELATED [IUPAC] synonym: "3''-O-demethylerythromycin" RELATED [ChemIDplus] synonym: "Abomacetin" RELATED [KEGG_COMPOUND] synonym: "erthromycin" RELATED [ChEBI] synonym: "ERYTHROMYCIN" RELATED [ChEMBL] synonym: "Erythromycin" RELATED [ChEMBL, KEGG_COMPOUND] synonym: "ERYTHROMYCIN A" EXACT [PDBeChem] synonym: "Erythromycin A" EXACT [ChEMBL, KEGG_COMPOUND] synonym: "Erythromycin C" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00199 xref: KEGG:C01912 xref: KEGG:D00140 xref: LINCS:LSM-3416 xref: MetaCyc:CPD-13804 xref: Patent:US2823203 xref: PDBeChem:ERY is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:48923 ! erythromycin relationship: has_functional_parent CHEBI:48848 ! erythronolide A relationship: is_conjugate_base_of CHEBI:64268 ! erythromycin A(1+) [Term] id: CHEBI:42485 name: formyl group namespace: chebi_ontology alt_id: CHEBI:24089 alt_id: CHEBI:42480 subset: 3_STAR synonym: "-CH(O)" RELATED [IUPAC] synonym: "-CHO" RELATED [IUPAC] synonym: "Fo" RELATED [CBN] synonym: "FORMYL GROUP" EXACT [PDBeChem] synonym: "H-CO-" RELATED [IUPAC] synonym: "methanoyl" RELATED [IUPAC] xref: PDBeChem:FOR is_a: CHEBI:27207 ! univalent carboacyl group relationship: is_substituent_group_from CHEBI:30751 ! formic acid [Term] id: CHEBI:43176 name: hydroxy group namespace: chebi_ontology alt_id: CHEBI:24706 alt_id: CHEBI:43171 subset: 3_STAR synonym: "-OH" RELATED [IUPAC] synonym: "HYDROXY GROUP" EXACT [PDBeChem] synonym: "hydroxy group" EXACT [UniProt] synonym: "hydroxyl" RELATED [ChEBI] synonym: "hydroxyl group" RELATED [ChEBI] xref: PDBeChem:OH is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:43254 name: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:38337 ! pyrimidone relationship: is_tautomer_of CHEBI:17568 ! uracil [Term] id: CHEBI:43474 name: hydrogenphosphate namespace: chebi_ontology alt_id: CHEBI:29139 alt_id: CHEBI:43470 def: "A phosphate ion that is the conjugate base of dihydrogenphosphate." [] subset: 3_STAR synonym: "[P(OH)O3](2-)" RELATED [MolBase] synonym: "[PO3(OH)](2-)" RELATED [IUPAC] synonym: "HPO4(2-)" RELATED [IUPAC] synonym: "hydrogen phosphate" RELATED [ChEBI] synonym: "HYDROGENPHOSPHATE ION" RELATED [PDBeChem] synonym: "INORGANIC PHOSPHATE GROUP" RELATED [PDBeChem] synonym: "phosphate" RELATED [UniProt] xref: MolBase:1628 xref: PDBeChem:PI xref: PDBeChem:PO4 is_a: CHEBI:35780 ! phosphate ion is_a: CHEBI:79388 ! divalent inorganic anion relationship: is_conjugate_acid_of CHEBI:18367 ! phosphate(3-) relationship: is_conjugate_base_of CHEBI:39745 ! dihydrogenphosphate relationship: RO:0000087 CHEBI:23357 ! has role cofactor relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite [Term] id: CHEBI:43968 name: meropenem namespace: chebi_ontology def: "A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively." [] subset: 3_STAR synonym: "(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-YLTHIO]-6-[(R)-1-HYDROXYETHYL]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC ACID" RELATED [PDBeChem] synonym: "(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "Antibiotic SM 7338" RELATED [DrugBank] synonym: "MEPM" RELATED [ChEBI] synonym: "Meropenem" EXACT [ChemIDplus] synonym: "meropenem anhydrous" RELATED [ChemIDplus] xref: DrugBank:DB00760 xref: LINCS:LSM-5208 xref: Patent:EP126587 xref: Patent:US4943569 xref: PDBeChem:MER xref: Wikipedia:Meropenem is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:46634 ! carbapenemcarboxylic acid is_a: CHEBI:46770 ! pyrrolidinecarboxamide is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:44137 name: tiamulin namespace: chebi_ontology alt_id: CHEBI:29695 def: "A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae." [] subset: 3_STAR xref: KEGG:C12065 xref: KEGG:D06127 xref: Patent:DE2248237 xref: Patent:US3919290 xref: PDBeChem:MUL xref: Wikipedia:Tiamulin is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:38032 ! carbotricyclic compound is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:52557 ! tetracyclic diterpenoid is_a: CHEBI:72588 ! semisynthetic derivative relationship: has_functional_parent CHEBI:8269 ! Pleuromutilin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:44976 name: phosphonic acid namespace: chebi_ontology alt_id: CHEBI:26067 def: "A phosphorus oxoacid that consists of a single pentavalent phosphorus covalently bound via single bonds to a single hydrogen and two hydroxy groups and via a double bond to an oxygen. The parent of the class of phosphonic acids." [] subset: 3_STAR synonym: "(HO)2HPO" RELATED [NIST_Chemistry_WebBook] synonym: "[PHO(OH)2]" RELATED [IUPAC] synonym: "H2PHO3" RELATED [IUPAC] synonym: "H3PO3" RELATED [ChEBI] synonym: "HPO(OH)2" RELATED [IUPAC] synonym: "Phosphite" RELATED [KEGG_COMPOUND] synonym: "Phosphonate" RELATED [KEGG_COMPOUND] synonym: "Phosphonic acid" EXACT [KEGG_COMPOUND] synonym: "phosphonic acid" EXACT [ChEBI] synonym: "Phosphonsaeure" RELATED [ChEBI] xref: KEGG:C06701 xref: PDBeChem:PHS xref: Wikipedia:Phosphonic_acid is_a: CHEBI:26069 ! phosphonic acids is_a: CHEBI:33457 ! phosphorus oxoacid relationship: is_conjugate_acid_of CHEBI:33462 ! phosphonate(1-) relationship: is_tautomer_of CHEBI:36361 ! phosphorous acid relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:45064 name: phosphite(3-) namespace: chebi_ontology alt_id: CHEBI:29197 alt_id: CHEBI:45060 def: "A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid." [] subset: 3_STAR synonym: "[PO3](3-)" RELATED [IUPAC] synonym: "Phosphit" RELATED [ChEBI] synonym: "phosphite" RELATED [IUPAC] synonym: "PHOSPHITE ION" RELATED [PDBeChem] synonym: "PO3(3-)" RELATED [IUPAC] xref: PDBeChem:PO3 is_a: CHEBI:26045 ! phosphite ion is_a: CHEBI:79387 ! trivalent inorganic anion relationship: is_conjugate_base_of CHEBI:29259 ! hydrogenphosphite [Term] id: CHEBI:45081 name: pentamidine namespace: chebi_ontology alt_id: CHEBI:45077 alt_id: CHEBI:7976 def: "A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease." [] subset: 3_STAR synonym: "1,5-bis(4-amidinophenoxy)pentane" RELATED [ChEBI] synonym: "4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide" RELATED [ChemIDplus] synonym: "4,4'-(pentamethylenedioxy)dibenzamidine" RELATED [ChemIDplus] synonym: "4,4'-Diamidinodiphenoxypentane" RELATED [DrugBank] synonym: "p,p'-(pentamethylenedioxy)dibenzamidine" RELATED [ChemIDplus] synonym: "pentamidin" RELATED [DrugCentral] synonym: "Pentamidine" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00738 xref: HMDB:HMDB0014876 xref: KEGG:C07420 xref: KEGG:D08333 xref: LINCS:LSM-4540 xref: Patent:EP975608 xref: Patent:GB507565 xref: Patent:US2006235001 xref: Patent:US2008167296 xref: Patent:US2008214569 xref: Patent:US2394003 xref: Patent:US7115665 xref: PDBeChem:PNT xref: Wikipedia:Pentamidine is_a: CHEBI:35359 ! carboxamidine is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:46786 ! diether relationship: is_conjugate_base_of CHEBI:64383 ! pentamidinium(2+) relationship: RO:0000087 CHEBI:130181 ! has role calmodulin antagonist relationship: RO:0000087 CHEBI:136651 ! has role S100 calcium-binding protein B inhibitor relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug relationship: RO:0000087 CHEBI:60643 ! has role NMDA receptor antagonist relationship: RO:0000087 CHEBI:63673 ! has role chemokine receptor 5 antagonist relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent relationship: RO:0000087 CHEBI:76395 ! has role EC 2.3.1.48 (histone acetyltransferase) inhibitor [Term] id: CHEBI:4511 name: dicloxacillin namespace: chebi_ontology def: "A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "Dicloxacillin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00485 xref: KEGG:C06950 xref: KEGG:D02348 xref: LINCS:LSM-5234 xref: Patent:GB978299 xref: Patent:US3239507 xref: Wikipedia:Dicloxacillin is_a: CHEBI:17334 ! penicillin is_a: CHEBI:23697 ! dichlorobenzene relationship: is_conjugate_acid_of CHEBI:52017 ! dicloxacillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:4520 name: diethofencarb namespace: chebi_ontology def: "A carbamate ester that is the isopropyl ester of (3,4-diethoxyphenyl)carbamic acid. A fungicide with strong activity against Botrytis cinerea and benzimidazole-resistant strains of Botryis spp." [] subset: 3_STAR synonym: "1-Methylethyl (3,4-diethoxyphenyl)carbamate" RELATED [ChemIDplus] synonym: "1-methylethyl N-(3,4-diethoxyphenyl)carbamate" RELATED [Alan_Wood's_Pesticides] synonym: "isopropyl (3,4-diethoxyphenyl)carbamate" RELATED [IUPAC] synonym: "Isopropyl 3,4-diethoxycarbanilate" RELATED [ChemIDplus] xref: KEGG:C11077 xref: PPDB:228 is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:87066 ! carbanilate fungicide relationship: has_functional_parent CHEBI:17296 ! aniline relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:45285 name: pyrazinecarboxamide namespace: chebi_ontology alt_id: CHEBI:45281 alt_id: CHEBI:8656 def: "A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis." [] subset: 3_STAR synonym: "2-carbamylpyrazine" RELATED [ChemIDplus] synonym: "2-pyrazinecarboxamide" RELATED [ChemIDplus] synonym: "Pyrazinamide" RELATED [KEGG_COMPOUND] synonym: "pyrazinamide" RELATED [UniProt] synonym: "pyrazine carboxamide" RELATED [NIST_Chemistry_WebBook] synonym: "PYRAZINE-2-CARBOXAMIDE" RELATED [PDBeChem] synonym: "pyrazineamide" RELATED [NIST_Chemistry_WebBook] synonym: "Pyrazinoic acid amide" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00339 xref: HMDB:HMDB0014483 xref: KEGG:C01956 xref: KEGG:D00144 xref: LINCS:LSM-5425 xref: PDBeChem:PZA xref: Wikipedia:Pyrazinamide is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:38314 ! pyrazines is_a: CHEBI:83628 ! N-acylammonia relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:50266 ! has role prodrug [Term] id: CHEBI:45367 name: rifabutin namespace: chebi_ontology alt_id: CHEBI:45364 alt_id: CHEBI:8857 subset: 3_STAR synonym: "1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV" RELATED [ChemIDplus] synonym: "4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S" RELATED [ChemIDplus] synonym: "4-N-isobutylspiropiperidylrifamycin S" RELATED [ChemIDplus] synonym: "Mycobutin (TN)" RELATED [KEGG_DRUG] synonym: "Rifabutin" EXACT [KEGG_COMPOUND, KEGG_DRUG] xref: DrugBank:DB00615 xref: KEGG:C07235 xref: KEGG:D00424 xref: KNApSAcK:C00027872 xref: Wikipedia:Rifabutin is_a: CHEBI:26580 ! rifamycins relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent [Term] id: CHEBI:45373 name: sulfanilamide namespace: chebi_ontology alt_id: CHEBI:45370 alt_id: CHEBI:9333 def: "A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position." [] subset: 3_STAR synonym: "4-aminobenzene sulfonic acid amide" RELATED [ChEBI] synonym: "4-azanylbenzenesulfonamide" RELATED [IUPAC] synonym: "p-aminobenzenesulfamide" RELATED [NIST_Chemistry_WebBook] synonym: "p-aminobenzenesulfonamide" RELATED [NIST_Chemistry_WebBook] synonym: "para-aminobenzenesulfonamide" RELATED [ChEBI] synonym: "Prontosil album" RELATED [KEGG_COMPOUND] synonym: "SA" RELATED [ChEBI] synonym: "Streptocide" RELATED [NIST_Chemistry_WebBook] synonym: "Sulfamine" RELATED [KEGG_COMPOUND] synonym: "sulfamine" RELATED [NIST_Chemistry_WebBook] synonym: "SULFANILAMIDE" EXACT [PDBeChem] synonym: "Sulfanilamide" EXACT [KEGG_COMPOUND] synonym: "sulphanilamide" RELATED [ChEBI] xref: DrugBank:DB00259 xref: HMDB:HMDB0014404 xref: KEGG:C07458 xref: KEGG:D08543 xref: LINCS:LSM-6524 xref: PDBeChem:SAN xref: VSDB:1924 xref: Wikipedia:Sulfanilamide is_a: CHEBI:48975 ! substituted aniline is_a: CHEBI:87228 ! sulfonamide antibiotic relationship: RO:0000087 CHEBI:23018 ! has role EC 4.2.1.1 (carbonic anhydrase) inhibitor relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:45599 name: dodecyl hydrogen sulfate namespace: chebi_ontology alt_id: CHEBI:32953 alt_id: CHEBI:45595 subset: 3_STAR synonym: "DODECYL SULFATE" RELATED [PDBeChem] synonym: "lauryl sulfuric acid" RELATED [ChemIDplus] synonym: "monododecyl hydrogen sulfate" RELATED [ChemIDplus] synonym: "sulfuric acid, monododecyl ester" RELATED [ChemIDplus] xref: PDBeChem:SDS is_a: CHEBI:29281 ! alkyl sulfate relationship: is_conjugate_acid_of CHEBI:23872 ! dodecyl sulfate [Term] id: CHEBI:45615 name: salicylhydroxamic acid namespace: chebi_ontology alt_id: CHEBI:9007 def: "A hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2." [] subset: 3_STAR synonym: "2-Hydroxybenzhydroxamic acid" RELATED [ChemIDplus] synonym: "2-Hydroxybenzohydroxamic acid" RELATED [ChemIDplus] synonym: "o-Hydroxybenzohydroxamic acid" RELATED [ChemIDplus] synonym: "Salicylohydroximic acid" RELATED [ChemIDplus] synonym: "SHAM" RELATED [ChEBI] xref: DrugBank:DB03819 xref: KEGG:C11343 xref: MetaCyc:CPD-6543 xref: Patent:CN101519365 xref: PDBeChem:SHA xref: Wikipedia:Salicylhydroxamic_acid is_a: CHEBI:24650 ! hydroxamic acid is_a: CHEBI:33853 ! phenols relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug relationship: RO:0000087 CHEBI:50635 ! has role EC 3.5.1.5 (urease) inhibitor relationship: RO:0000087 CHEBI:79093 ! has role EC 1.11.2.2 (myeloperoxidase) inhibitor [Term] id: CHEBI:45696 name: hydrogensulfate namespace: chebi_ontology alt_id: CHEBI:29199 alt_id: CHEBI:45693 subset: 3_STAR synonym: "[SO3(OH)](-)" RELATED [IUPAC] synonym: "HSO4(-)" RELATED [IUPAC] synonym: "HYDROGEN SULFATE" RELATED [PDBeChem] synonym: "hydrogensulfate" EXACT [IUPAC] is_a: CHEBI:33482 ! sulfur oxoanion relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid [Term] id: CHEBI:45924 name: trimethoprim namespace: chebi_ontology alt_id: CHEBI:45921 alt_id: CHEBI:9731 def: "An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge." [] subset: 3_STAR synonym: "2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine" RELATED [NIST_Chemistry_WebBook] synonym: "5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine" RELATED [NIST_Chemistry_WebBook] synonym: "Proloprim" RELATED [ChemIDplus] synonym: "TRIMETHOPRIM" EXACT [PDBeChem] synonym: "Trimethoprim" EXACT [KEGG_COMPOUND] synonym: "Trimpex" RELATED [ChemIDplus] xref: DrugBank:DB00440 xref: HMDB:HMDB0014583 xref: KEGG:C01965 xref: KEGG:D00145 xref: LINCS:LSM-5246 xref: PDBeChem:TOP xref: VSDB:1745 xref: Wikipedia:Trimethoprim is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:51683 ! methoxybenzenes relationship: RO:0000087 CHEBI:35498 ! has role diuretic relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:45979 name: thiabendazole namespace: chebi_ontology alt_id: CHEBI:45977 alt_id: CHEBI:9526 def: "A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium." [] subset: 3_STAR synonym: "2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE" RELATED [PDBeChem] synonym: "2-(1,3-thiazol-4-yl)benzimidazole" RELATED [Alan_Wood's_Pesticides] synonym: "2-(4-thiazolyl)-1H-benzimidazole" RELATED [Alan_Wood's_Pesticides] synonym: "2-(thiazol-4-yl)benzimidazole" RELATED [Alan_Wood's_Pesticides] synonym: "4-(2-benzimidazolyl)thiazole" RELATED [ChemIDplus] synonym: "MK 360" RELATED [ChemIDplus] synonym: "TBZ" RELATED [ChemIDplus] synonym: "Thiabendazole" EXACT [KEGG_COMPOUND] synonym: "Tiabendazole" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00730 xref: HMDB:HMDB0014868 xref: KEGG:D00372 xref: LINCS:LSM-3741 xref: MetaCyc:THIABENDAZOLE xref: Patent:US3017415 xref: PDBeChem:TMG xref: PPDB:629 xref: VSDB:629 xref: Wikipedia:Thiabendazole is_a: CHEBI:38418 ! 1,3-thiazoles is_a: CHEBI:87036 ! benzimidazole fungicide relationship: has_parent_hydride CHEBI:41275 ! 1H-benzimidazole relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:46024 name: trichostatin A namespace: chebi_ontology alt_id: CHEBI:39145 alt_id: CHEBI:46022 subset: 3_STAR synonym: "(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide" RELATED [ChemIDplus] synonym: "TRICHOSTATIN A" EXACT [PDBeChem] synonym: "TSA" RELATED [ChemIDplus] xref: DrugBank:DB04297 xref: HMDB:HMDB0259177 xref: KNApSAcK:C00016002 xref: PDBeChem:TSN xref: Wikipedia:Trichostatin_A is_a: CHEBI:24650 ! hydroxamic acid is_a: CHEBI:39146 ! trichostatin is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: has_functional_parent CHEBI:39158 ! (R)-trichostatic acid relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:61115 ! has role EC 3.5.1.98 (histone deacetylase) inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:46077 name: 4H-1,2,4-triazole namespace: chebi_ontology alt_id: CHEBI:35548 alt_id: CHEBI:46076 subset: 3_STAR synonym: "1,2,4-TRIAZOLE" RELATED [PDBeChem] xref: PDBeChem:TRI is_a: CHEBI:35560 ! 1,2,4-triazole relationship: is_tautomer_of CHEBI:35550 ! 1H-1,2,4-triazole relationship: is_tautomer_of CHEBI:35561 ! 3H-1,2,4-triazole [Term] id: CHEBI:46081 name: fluconazole namespace: chebi_ontology alt_id: CHEBI:46079 alt_id: CHEBI:5099 def: "A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis." [] subset: 3_STAR synonym: "2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol" RELATED [ChemIDplus] synonym: "2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL" RELATED [PDBeChem] synonym: "Elazor" RELATED [ChemIDplus] synonym: "fluconazole" EXACT [UniProt] xref: DrugBank:DB00196 xref: HMDB:HMDB0014342 xref: KEGG:D00322 xref: LINCS:LSM-2106 xref: Patent:GB2099818 xref: Patent:US4404216 xref: PDBeChem:TPF xref: Wikipedia:Fluconazole is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:38582 ! difluorobenzene is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: has_functional_parent CHEBI:38584 ! 1,3-difluorobenzene relationship: has_parent_hydride CHEBI:35550 ! 1H-1,2,4-triazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:46416 name: virginiamycin S1 namespace: chebi_ontology alt_id: CHEBI:9998 def: "A cyclodepsipeptide that is N-(3-hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine in which the carboxy group of the 2-phenylglycine moiety has undergone formal intramolecular condensation with the hydroxy group of the N-(3-hydroxypicolinoyl)-L-threonyl to give the corresponding 19-membered ring lactone. It is one of the two major components of the antibacterial drug virginiamycin, produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others." [] subset: 3_STAR synonym: "N-((3-hydroxy-2-pyridinyl)carbonyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine rho-lactone" RELATED [ChemIDplus] synonym: "N-(3-hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine rho-lactone" RELATED [ChemIDplus] synonym: "virginiamycin factor S" RELATED [ChemIDplus] synonym: "Virginiamycin S1" EXACT [KEGG_COMPOUND] synonym: "virginiamycin S1" EXACT [ChemIDplus] xref: DrugBank:DB04805 xref: KEGG:C11269 xref: PDBeChem:VRS xref: Wikipedia:Virginiamycin_S1 is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:35213 ! cyclodepsipeptide relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:46577 name: dextrofloxacin namespace: chebi_ontology def: "The (R)-enantiomer of ofloxacin." [] subset: 3_STAR synonym: "(+)-ofloxacin" RELATED [ChEBI] synonym: "(R)-(+)-ofloxacin" RELATED [ChEBI] synonym: "(R)-ofloxacin" RELATED [ChEBI] synonym: "D-levofloxacin" RELATED [DrugBank] synonym: "D-ofloxacin" RELATED [ChemIDplus] synonym: "dextrofloxacine" RELATED [PDBeChem] synonym: "DR 3354" RELATED [ChEBI] synonym: "DR-3354" RELATED [ChEBI] synonym: "DR3354" RELATED [ChEBI] synonym: "R-(+)-ofloxacin" RELATED [ChEBI] synonym: "R-ofloxacin" RELATED [ChemIDplus] xref: DrugBank:DB03034 xref: PDBeChem:XED is_a: CHEBI:194135 ! 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_enantiomer_of CHEBI:63598 ! levofloxacin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor [Term] id: CHEBI:46629 name: oxo group namespace: chebi_ontology alt_id: CHEBI:29353 alt_id: CHEBI:44607 subset: 3_STAR synonym: "=O" RELATED [IUPAC] synonym: "OXO GROUP" EXACT [PDBeChem] xref: PDBeChem:O is_a: CHEBI:33246 ! inorganic group [Term] id: CHEBI:46633 name: carbapenems namespace: chebi_ontology def: "The class of beta-lactam antibiotics that whose members have a carbapenem skeleton which is variously substituted at positions 3, 4, and 6." [] subset: 3_STAR xref: Wikipedia:Carbapenem is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:27933 ! beta-lactam antibiotic relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:46634 name: carbapenemcarboxylic acid namespace: chebi_ontology subset: 3_STAR synonym: "carbapenemcarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:46633 ! carbapenems [Term] id: CHEBI:46662 name: mineral namespace: chebi_ontology def: "In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals')." [] subset: 3_STAR synonym: "mineral" EXACT [ChEBI] synonym: "Minerale" RELATED [ChEBI] synonym: "minerales" RELATED [ChEBI] synonym: "minerals" RELATED [ChEBI] synonym: "mineraux" RELATED [ChEBI] xref: Wikipedia:Mineral is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:46686 name: azaalkane namespace: chebi_ontology subset: 3_STAR synonym: "azaalkanes" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:46687 name: diazaalkane namespace: chebi_ontology subset: 3_STAR synonym: "diazaalkanes" RELATED [ChEBI] is_a: CHEBI:39474 ! polyazaalkane [Term] id: CHEBI:46733 name: oxabicycloalkane namespace: chebi_ontology subset: 3_STAR synonym: "oxabicycloalkanes" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:46761 name: dipeptide namespace: chebi_ontology alt_id: CHEBI:23835 alt_id: CHEBI:4634 def: "Any molecule that contains two amino-acid residues connected by peptide linkages." [] subset: 3_STAR synonym: "Dipeptid" RELATED [ChEBI] synonym: "Dipeptide" EXACT [KEGG_COMPOUND] synonym: "dipeptides" RELATED [ChEBI] xref: KEGG:C00107 is_a: CHEBI:25676 ! oligopeptide relationship: is_tautomer_of CHEBI:90799 ! dipeptide zwitterion [Term] id: CHEBI:46770 name: pyrrolidinecarboxamide namespace: chebi_ontology subset: 3_STAR synonym: "pyrrolidinecarboxamides" RELATED [ChEBI] is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:38260 ! pyrrolidines [Term] id: CHEBI:46774 name: polyether namespace: chebi_ontology def: "Any ether that contains more than one ether linkage." [] subset: 3_STAR synonym: "polyether" EXACT [ChEBI] synonym: "polyethers" RELATED [ChEBI] is_a: CHEBI:25698 ! ether [Term] id: CHEBI:46786 name: diether namespace: chebi_ontology def: "A polyether in which the number of ether linkages is 2." [] subset: 3_STAR synonym: "diether" EXACT [ChEBI] synonym: "diethers" RELATED [ChEBI] is_a: CHEBI:46774 ! polyether [Term] id: CHEBI:46787 name: solvent namespace: chebi_ontology def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." [] subset: 3_STAR synonym: "Loesungsmittel" RELATED [ChEBI] synonym: "solvant" RELATED [ChEBI] synonym: "solvents" RELATED [ChEBI] xref: Wikipedia:Solvent is_a: CHEBI:33232 ! application is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:46812 name: 1,3-oxazoles namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:35790 ! oxazole [Term] id: CHEBI:46844 name: N-acylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-acylpiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:32988 ! amide [Term] id: CHEBI:46845 name: N-alkylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-alkylpiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:46847 name: N-iminopiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-iminopiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines [Term] id: CHEBI:46848 name: N-arylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-arylpiperazines" RELATED [ChEBI] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:46850 name: organoammonium salt namespace: chebi_ontology subset: 3_STAR synonym: "organoammonium salts" RELATED [ChEBI] is_a: CHEBI:35276 ! ammonium compound [Term] id: CHEBI:46883 name: carboxy group namespace: chebi_ontology alt_id: CHEBI:23025 alt_id: CHEBI:41420 subset: 3_STAR synonym: "-C(O)OH" RELATED [IUPAC] synonym: "-CO2H" RELATED [ChEBI] synonym: "-COOH" RELATED [IUPAC] synonym: "CARBOXY GROUP" EXACT [PDBeChem] synonym: "carboxyl group" RELATED [ChEBI] xref: PDBeChem:FMT is_a: CHEBI:33249 ! organyl group [Term] id: CHEBI:46895 name: lipopeptide namespace: chebi_ontology def: "A compound consisting of a peptide with attached lipid." [] subset: 3_STAR synonym: "lipopeptides" RELATED [ChEBI] synonym: "LP" RELATED [ChEBI] xref: Wikipedia:Lipopeptide is_a: CHEBI:16670 ! peptide is_a: CHEBI:18059 ! lipid [Term] id: CHEBI:46912 name: ornithinium(1+) namespace: chebi_ontology subset: 3_STAR synonym: "ornithine monocation" RELATED [JCBN] synonym: "ornithinium(1+)" EXACT [JCBN] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:18257 ! ornithine relationship: is_conjugate_base_of CHEBI:46913 ! ornithinium(2+) relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:46913 name: ornithinium(2+) namespace: chebi_ontology subset: 3_STAR synonym: "ornithine dication" RELATED [JCBN] synonym: "ornithinium(2+)" EXACT [JCBN] is_a: CHEBI:33719 ! alpha-amino-acid cation relationship: is_conjugate_acid_of CHEBI:46912 ! ornithinium(1+) [Term] id: CHEBI:46920 name: N-methylpiperazine namespace: chebi_ontology subset: 3_STAR synonym: "N-methylpiperazines" RELATED [ChEBI] is_a: CHEBI:46845 ! N-alkylpiperazine [Term] id: CHEBI:46942 name: oxanes namespace: chebi_ontology def: "Any organic heteromonocyclic compoundthat is oxane or its substituted derivatives." [] subset: 3_STAR synonym: "tetrahydropyrans" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:46952 name: oxazinane namespace: chebi_ontology subset: 3_STAR synonym: "oxazinanes" RELATED [ChEBI] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle [Term] id: CHEBI:47017 name: tetrahydrofuranol namespace: chebi_ontology subset: 3_STAR synonym: "tetrahydrofuranols" RELATED [ChEBI] is_a: CHEBI:26912 ! oxolanes [Term] id: CHEBI:47019 name: dihydroxytetrahydrofuran namespace: chebi_ontology subset: 3_STAR synonym: "dihydroxytetrahydrofurans" RELATED [ChEBI] is_a: CHEBI:47017 ! tetrahydrofuranol [Term] id: CHEBI:471744 name: imipenem namespace: chebi_ontology alt_id: CHEBI:5879 def: "A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup." [] subset: 3_STAR synonym: "(5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid" RELATED [ChemIDplus] synonym: "(5R,6S)-3-(2-Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [ChEMBL] synonym: "(5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure" RELATED [ChemIDplus] synonym: "Imipenem" EXACT [KEGG_COMPOUND] synonym: "Imipenem anhydrous" RELATED [KEGG_COMPOUND] synonym: "imipenemum" RELATED [ChemIDplus] synonym: "N-formimidoyl thienamycin" RELATED [Patent] synonym: "N-formimidoylthienamycin" RELATED [ChemIDplus] xref: DrugBank:DB01598 xref: KEGG:C06665 xref: KEGG:D04515 xref: LINCS:LSM-6568 xref: Patent:BE848545 xref: Patent:US4194047 xref: Wikipedia:Imipenem is_a: CHEBI:46633 ! carbapenems is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_tautomer_of CHEBI:190509 ! imipenem zwitterion relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:472657 name: cefixime namespace: chebi_ontology alt_id: CHEBI:3487 def: "A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections." [] subset: 3_STAR synonym: "(-)-cefixim" RELATED [ChemIDplus] synonym: "(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] xref: DrugBank:DB00671 xref: KEGG:C06881 xref: KEGG:D00258 xref: Patent:EP30630 xref: Patent:US4409214 is_a: CHEBI:23066 ! cephalosporin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:473992 name: nystatin A1 namespace: chebi_ontology alt_id: CHEBI:31926 def: "A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species." [] subset: 3_STAR synonym: "nystatin A1" EXACT [LIPID_MAPS] xref: HMDB:HMDB0242564 xref: KEGG:C12155 xref: VSDB:2985 is_a: CHEBI:59676 ! nystatins [Term] id: CHEBI:474053 name: cefazolin namespace: chebi_ontology alt_id: CHEBI:3482 def: "A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively." [] subset: 3_STAR synonym: "(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [IUPAC] synonym: "Cefamezin" RELATED [ChemIDplus] synonym: "Cephamezine" RELATED [ChemIDplus] synonym: "Cephazolidin" RELATED [ChemIDplus] synonym: "Cephazolin" RELATED [ChemIDplus] synonym: "Cephazoline" RELATED [ChemIDplus] synonym: "CEZ" RELATED [ChEBI] xref: DrugBank:DB01327 xref: HMDB:HMDB0015422 xref: KEGG:C06880 xref: KEGG:D02299 xref: LINCS:LSM-34744 xref: Patent:US3516997 xref: VSDB:1910 xref: Wikipedia:Cefazolin is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:35689 ! tetrazoles is_a: CHEBI:38099 ! thiadiazoles is_a: CHEBI:88225 ! beta-lactam antibiotic allergen relationship: is_conjugate_acid_of CHEBI:53657 ! cefazolin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:474180 name: caspofungin namespace: chebi_ontology alt_id: CHEBI:599509 def: "A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall." [] subset: 3_STAR synonym: "(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide" RELATED [ChemIDplus] synonym: "1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0" RELATED [ChEBI] synonym: "Caspofungin" EXACT [ChEMBL] xref: DrugBank:DB00520 xref: KEGG:D07626 xref: Patent:US5378804 xref: Patent:WO9421677 is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:57248 ! echinocandin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: has_functional_parent CHEBI:131609 ! pneumocandin B0 [Term] id: CHEBI:47518 name: (2S,4R)-ketoconazole namespace: chebi_ontology def: "A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2S,4R)-configuration." [] subset: 3_STAR synonym: "(2S,4R)-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" RELATED [ChEBI] synonym: "(2S,4R)-ketoconazole" EXACT [UniProt] synonym: "1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE" RELATED [PDBeChem] xref: PDBeChem:KLN is_a: CHEBI:86411 ! cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine relationship: is_enantiomer_of CHEBI:48336 ! (2R,4S)-ketoconazole [Term] id: CHEBI:47519 name: ketoconazole namespace: chebi_ontology alt_id: CHEBI:6126 def: "A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole." [] subset: 3_STAR synonym: "(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine" RELATED [ChemIDplus] synonym: "cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine" RELATED [ChemIDplus] xref: DrugBank:DB01026 xref: HMDB:HMDB0012242 xref: KEGG:D00351 xref: Patent:DE2804096 xref: Patent:US4144346 is_a: CHEBI:60911 ! racemate is_a: CHEBI:87069 ! imidazole antifungal drug is_a: CHEBI:87071 ! conazole antifungal drug relationship: BFO:0000051 CHEBI:47518 ! has part (2S,4R)-ketoconazole relationship: BFO:0000051 CHEBI:48336 ! has part (2R,4S)-ketoconazole [Term] id: CHEBI:47724 name: vancomycin aglycone namespace: chebi_ontology def: "A peptide antibiotic that is vancomycin lacking the disaccharide moiety." [] subset: 3_STAR synonym: "Aglucovancomycin B" RELATED [ChemIDplus] synonym: "Balhimycin aglycon" RELATED [ChemIDplus] xref: MetaCyc:CPD-15745 is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:37407 ! cyclic ether relationship: is_conjugate_acid_of CHEBI:77981 ! vancomycin aglycone(1-) relationship: is_tautomer_of CHEBI:75954 ! vancomycin aglycone zwitterion relationship: RO:0000087 CHEBI:25212 ! has role metabolite [Term] id: CHEBI:47779 name: aminoglycoside namespace: chebi_ontology subset: 3_STAR synonym: "aminoglycosides" RELATED [ChEBI] is_a: CHEBI:24400 ! glycoside [Term] id: CHEBI:47811 name: penamcarboxylate namespace: chebi_ontology subset: 3_STAR synonym: "penamcarboxylates" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:35992 ! penams [Term] id: CHEBI:478164 name: cefepime namespace: chebi_ontology alt_id: CHEBI:3486 alt_id: CHEBI:473919 def: "A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] synonym: "Cefepime" EXACT [KEGG_COMPOUND] synonym: "cefepime" EXACT [ChEMBL] synonym: "CFPM" RELATED [ChEBI] xref: DrugBank:DB01413 xref: KEGG:C08111 xref: KEGG:D02376 xref: Patent:DE3307550 xref: Patent:US4406899 xref: Wikipedia:Cefepime is_a: CHEBI:23066 ! cephalosporin is_a: CHEBI:36816 ! oxime O-ether relationship: is_conjugate_base_of CHEBI:59349 ! cefepime(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:47857 name: ureas namespace: chebi_ontology alt_id: CHEBI:27220 alt_id: CHEBI:36947 subset: 3_STAR synonym: "urea derivatives" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide relationship: has_functional_parent CHEBI:16199 ! urea [Term] id: CHEBI:47867 name: indicator namespace: chebi_ontology def: "Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc." [] subset: 3_STAR synonym: "Indikator" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:47880 name: steroid ester namespace: chebi_ontology alt_id: CHEBI:26762 subset: 3_STAR synonym: "steroid esters" RELATED [ChEBI] xref: KEGG:C15506 is_a: CHEBI:35341 ! steroid is_a: CHEBI:35701 ! ester [Term] id: CHEBI:47881 name: 3-oxo monocarboxylic acid namespace: chebi_ontology alt_id: CHEBI:13600 alt_id: CHEBI:1619 alt_id: CHEBI:35949 subset: 3_STAR synonym: "3-Keto acid" RELATED [KEGG_COMPOUND] synonym: "3-Oxo acid" RELATED [KEGG_COMPOUND] synonym: "3-oxo monocarboxylic acids" RELATED [ChEBI] synonym: "3-oxomonocarboxylic acid" RELATED [ChEBI] synonym: "3-oxomonocarboxylic acids" RELATED [ChEBI] xref: KEGG:C01656 is_a: CHEBI:35871 ! oxo monocarboxylic acid relationship: is_conjugate_acid_of CHEBI:35973 ! 3-oxo monocarboxylic acid anion [Term] id: CHEBI:47891 name: steroid acid namespace: chebi_ontology def: "Any steroid substituted by at least one carboxy group." [] subset: 3_STAR synonym: "steroid acids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid is_a: CHEBI:64709 ! organic acid relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion [Term] id: CHEBI:47956 name: thiocarboxamide namespace: chebi_ontology def: "Any primary amide having its amide oxygen replaced by sulfur." [] subset: 3_STAR synonym: "thioamide" RELATED [ChEBI] synonym: "thiocarboxamides" RELATED [ChEBI] synonym: "thionoamide" RELATED [ChEBI] is_a: CHEBI:33256 ! primary amide [Term] id: CHEBI:47985 name: enol ether namespace: chebi_ontology def: "Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage." [] subset: 3_STAR synonym: "enol ether" EXACT [ChEBI] synonym: "enol ethers" RELATED [ChEBI] is_a: CHEBI:25698 ! ether is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:48001 name: protein synthesis inhibitor namespace: chebi_ontology def: "A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein." [] subset: 3_STAR synonym: "protein synthesis antagonist" RELATED [ChEBI] synonym: "protein synthesis antagonists" RELATED [ChEBI] synonym: "protein synthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:48080 name: brefeldin A namespace: chebi_ontology def: "A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity." [] subset: 3_STAR synonym: "ascotoxin" RELATED [ChemIDplus] synonym: "Brefeldin A" EXACT [ChemIDplus] synonym: "cyanein" RELATED [ChemIDplus] synonym: "decumbin" RELATED [ChemIDplus] is_a: CHEBI:25105 ! macrolide antibiotic relationship: RO:0000087 CHEBI:76964 ! has role Penicillium metabolite [Term] id: CHEBI:4811 name: epoxiconazole namespace: chebi_ontology def: "A racemate composed of equimolar amounts of (2S,3R)- and (2R,3S)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms." [] subset: 3_STAR synonym: "(2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole" RELATED [Alan_Wood's_Pesticides] synonym: "rel-1-[[(2R,3S)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole" RELATED [Alan_Wood's_Pesticides] xref: KEGG:C11229 xref: Wikipedia:Epoxiconazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: BFO:0000051 CHEBI:83759 ! has part (2S,3R)-epoxiconazole relationship: BFO:0000051 CHEBI:83761 ! has part (2R,3S)-epoxiconazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:48121 name: polyene namespace: chebi_ontology def: "An olefin that contains more than one carbon-carbon double bond." [] subset: 3_STAR synonym: "polyenes" RELATED [ChEBI] is_a: CHEBI:33641 ! olefin [Term] id: CHEBI:48132 name: tetracenomycin namespace: chebi_ontology def: "A polyketide based on a tetracene ring structure." [] subset: 3_STAR synonym: "tetracenomycins" RELATED [ChEBI] is_a: CHEBI:26188 ! polyketide relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:48154 name: sulfur oxide namespace: chebi_ontology subset: 3_STAR synonym: "oxides of sulfur" RELATED [ChEBI] synonym: "Schwefeloxide" RELATED [ChEBI] synonym: "sulfur oxides" RELATED [ChEBI] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:48219 name: disinfectant namespace: chebi_ontology def: "An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity." [] subset: 3_STAR synonym: "desinfectant" RELATED [ChEBI] synonym: "Desinfektionsmittel" RELATED [ChEBI] synonym: "disinfectants" RELATED [ChEBI] synonym: "disinfecting agent" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent [Term] id: CHEBI:48336 name: (2R,4S)-ketoconazole namespace: chebi_ontology def: "A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration." [] subset: 3_STAR synonym: "(2R,4S)-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" RELATED [ChEBI] synonym: "(2R,4S)-ketoconazole" EXACT [UniProt] xref: LINCS:LSM-5430 xref: PDBeChem:KKK is_a: CHEBI:86411 ! cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine relationship: is_enantiomer_of CHEBI:47518 ! (2S,4R)-ketoconazole [Term] id: CHEBI:48339 name: 1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine namespace: chebi_ontology def: "A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively." [] subset: 3_STAR xref: DrugBank:DB01026 xref: LINCS:LSM-5148 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:25698 ! ether is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:46844 ! N-acylpiperazine is_a: CHEBI:46848 ! N-arylpiperazine [Term] id: CHEBI:48343 name: disulfide namespace: chebi_ontology def: "Compounds of structure RSSR'." [] subset: 3_STAR synonym: "disulfides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:48354 name: polar solvent namespace: chebi_ontology def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." [] subset: 3_STAR synonym: "polar solvents" RELATED [ChEBI] is_a: CHEBI:46787 ! solvent [Term] id: CHEBI:48355 name: non-polar solvent namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:46787 ! solvent [Term] id: CHEBI:48356 name: protic solvent namespace: chebi_ontology def: "A polar solvent that is capable of acting as a hydron (proton) donor." [] subset: 3_STAR is_a: CHEBI:39141 ! Bronsted acid is_a: CHEBI:48354 ! polar solvent [Term] id: CHEBI:48359 name: protophilic solvent namespace: chebi_ontology def: "Solvent that is capable of acting as a hydron (proton) acceptor." [] subset: 3_STAR synonym: "HBA solvent" RELATED [ChEBI] synonym: "hydrogen bond acceptor solvent" RELATED [ChEBI] is_a: CHEBI:39142 ! Bronsted base is_a: CHEBI:48354 ! polar solvent [Term] id: CHEBI:48360 name: amphiprotic solvent namespace: chebi_ontology def: "Self-ionizing solvent possessing both characteristics of Bronsted acids and bases." [] subset: 3_STAR is_a: CHEBI:48356 ! protic solvent is_a: CHEBI:48359 ! protophilic solvent [Term] id: CHEBI:48376 name: carbamimidic acid namespace: chebi_ontology subset: 3_STAR synonym: "carbamimic acid" RELATED [ChemIDplus] synonym: "carbonamidimidic acid" RELATED [IUPAC] synonym: "H2N-C(=NH)-OH" RELATED [IUPAC] synonym: "H2N-C(OH)=NH" RELATED [IUPAC] synonym: "HO-C(=NH)-NH2" RELATED [IUPAC] synonym: "Isoharnstoff" RELATED [ChEBI] synonym: "isourea" RELATED [ChemIDplus] synonym: "pseudourea" RELATED [ChemIDplus] is_a: CHEBI:48379 ! isourea is_a: CHEBI:64708 ! one-carbon compound relationship: is_tautomer_of CHEBI:16199 ! urea [Term] id: CHEBI:48377 name: imidic acid namespace: chebi_ontology def: "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH)." [] subset: 3_STAR synonym: "imidic acid" EXACT [ChEBI] synonym: "imidic acids" RELATED [ChEBI] synonym: "imino acids" RELATED [IUPAC] is_a: CHEBI:33241 ! oxoacid derivative is_a: CHEBI:51143 ! nitrogen molecular entity [Term] id: CHEBI:48378 name: carboximidic acid namespace: chebi_ontology subset: 3_STAR synonym: "carboximidic acid" EXACT [ChEBI] synonym: "carboximidic acids" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:48377 ! imidic acid [Term] id: CHEBI:48379 name: isourea namespace: chebi_ontology def: "A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives." [] subset: 3_STAR synonym: "isoureas" RELATED [ChEBI] is_a: CHEBI:48378 ! carboximidic acid [Term] id: CHEBI:48422 name: angiogenesis inhibitor namespace: chebi_ontology alt_id: CHEBI:67170 def: "An agent and endogenous substances that antagonize or inhibit the development of new blood vessels." [] subset: 3_STAR synonym: "angiogenesis antagonist" RELATED [ChEBI] synonym: "angiostatic agents" RELATED [ChEBI] synonym: "anti-angiogenic agent" RELATED [ChEBI] xref: Wikipedia:Angiogenesis_inhibitor is_a: CHEBI:23888 ! drug [Term] id: CHEBI:48535 name: aryloxypyrimidine namespace: chebi_ontology subset: 3_STAR synonym: "aryloxypyrimidines" RELATED [ChEBI] is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39447 ! pyrimidines [Term] id: CHEBI:48589 name: piperidones namespace: chebi_ontology subset: 3_STAR synonym: "piperidone" RELATED [ChEBI] is_a: CHEBI:26151 ! piperidines is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:48626 name: pyranoindolizinoquinoline namespace: chebi_ontology subset: 3_STAR synonym: "pyranoindolizinoquinolines" RELATED [ChEBI] is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38164 ! organic heteropentacyclic compound [Term] id: CHEBI:48705 name: agonist namespace: chebi_ontology def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." [] subset: 3_STAR synonym: "agonista" RELATED [ChEBI] synonym: "agoniste" RELATED [ChEBI] synonym: "agonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:48706 name: antagonist namespace: chebi_ontology def: "Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances." [] subset: 3_STAR synonym: "antagonista" RELATED [ChEBI] synonym: "antagoniste" RELATED [ChEBI] synonym: "antagonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:4877 name: ethambutol namespace: chebi_ontology alt_id: CHEBI:133410 alt_id: CHEBI:659237 alt_id: CHEBI:678172 def: "An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone." [] subset: 3_STAR synonym: "(+)-2,2'-(ethylenediimino)di-1-butanol" RELATED [ChemIDplus] synonym: "(+)-ethambutol" RELATED [ChEBI] synonym: "(+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine" RELATED [ChemIDplus] synonym: "(+)-S,S-ethambutol" RELATED [ChemIDplus] synonym: "(2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol" RELATED [ChEBI] synonym: "(S,S)-ethambutol" RELATED [ChEBI] synonym: "EMB" RELATED [ChEBI] synonym: "Ethambutol" EXACT [KEGG_COMPOUND] synonym: "S,S-Ethambutol" RELATED [ChEMBL] xref: DrugBank:DB00330 xref: KEGG:C06984 xref: KEGG:D07925 xref: Wikipedia:Ethambutol is_a: CHEBI:23981 ! ethanolamines is_a: CHEBI:31577 ! ethylenediamine derivative relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:48819 name: cyano group namespace: chebi_ontology alt_id: CHEBI:36824 alt_id: CHEBI:48818 subset: 3_STAR synonym: "-C#N" RELATED [IUPAC] synonym: "-CN" RELATED [IUPAC] synonym: "carbonitrile group" RELATED [ChEBI] synonym: "CYANIDE GROUP" RELATED [PDBeChem] synonym: "NC-" RELATED [IUPAC] xref: PDBeChem:CYN is_a: CHEBI:36823 ! pseudohalo group relationship: is_substituent_group_from CHEBI:18407 ! hydrogen cyanide [Term] id: CHEBI:48848 name: erythronolide A namespace: chebi_ontology subset: 3_STAR synonym: "Erythronolid A" RELATED [ChEBI] is_a: CHEBI:23955 ! erythronolide [Term] id: CHEBI:4885 name: ethionamide namespace: chebi_ontology def: "A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide." [] subset: 3_STAR synonym: "2-ethyl-4-thiopyridylamide" RELATED [ChEBI] synonym: "ETH" RELATED [DrugBank] synonym: "Ethinamide" RELATED [DrugBank] synonym: "Ethionamide" EXACT [KEGG_COMPOUND] synonym: "ethionamide" EXACT [UniProt] synonym: "Ethioniamide" RELATED [DrugBank] synonym: "Ethylisothiamide" RELATED [DrugBank] synonym: "Ethyonomide" RELATED [DrugBank] synonym: "Etionamid" RELATED [DrugBank] synonym: "Etionamide" RELATED [DrugBank] synonym: "Etioniamid" RELATED [DrugBank] synonym: "ETP" RELATED [DrugBank] xref: DrugBank:DB00609 xref: HMDB:HMDB0014747 xref: KEGG:C07665 xref: KEGG:D00591 xref: LINCS:LSM-5620 xref: Patent:GB800250 xref: Wikipedia:Ethionamide is_a: CHEBI:26421 ! pyridines is_a: CHEBI:47956 ! thiocarboxamide relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:35679 ! has role antilipemic drug relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug relationship: RO:0000087 CHEBI:50185 ! has role fatty acid synthesis inhibitor relationship: RO:0000087 CHEBI:50266 ! has role prodrug [Term] id: CHEBI:48854 name: sulfurous acid namespace: chebi_ontology alt_id: CHEBI:26837 alt_id: CHEBI:9344 subset: 3_STAR synonym: "[SO(OH)2]" RELATED [IUPAC] synonym: "acide sulfureux" RELATED [ChEBI] synonym: "acido sulfuroso" RELATED [ChEBI] synonym: "H2SO3" RELATED [IUPAC] synonym: "S(O)(OH)2" RELATED [IUPAC] synonym: "schweflige Saeure" RELATED [ChemIDplus] synonym: "Sulfite" RELATED [KEGG_COMPOUND] synonym: "Sulfurous acid" EXACT [KEGG_COMPOUND] synonym: "sulphurous acid" RELATED [ChemIDplus] xref: KEGG:C00094 xref: KNApSAcK:C00019662 xref: PDBeChem:SO3 is_a: CHEBI:33402 ! sulfur oxoacid relationship: is_conjugate_acid_of CHEBI:17137 ! hydrogensulfite relationship: is_tautomer_of CHEBI:29214 ! sulfonic acid [Term] id: CHEBI:48891 name: thiazolidinone namespace: chebi_ontology subset: 3_STAR synonym: "thiazolidinones" RELATED [ChEBI] is_a: CHEBI:35622 ! thiazolidines [Term] id: CHEBI:48901 name: thiazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom." [] subset: 3_STAR synonym: "thiazole" RELATED [ChEBI] is_a: CHEBI:38106 ! organosulfur heterocyclic compound is_a: CHEBI:68452 ! azole [Term] id: CHEBI:48908 name: triazolobenzothiazole namespace: chebi_ontology subset: 3_STAR synonym: "triazolobenzothiazoles" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38106 ! organosulfur heterocyclic compound [Term] id: CHEBI:48923 name: erythromycin namespace: chebi_ontology def: "Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus)." [] subset: 3_STAR synonym: "eritromicina" RELATED [ChEBI] synonym: "erthromycin" RELATED [ChEBI] synonym: "erythromycine" RELATED [ChEBI] xref: DrugBank:DB00199 xref: HMDB:HMDB0014344 xref: Patent:US2653899 xref: Wikipedia:Erythromycin is_a: CHEBI:23953 ! erythromycins relationship: is_conjugate_acid_of CHEBI:64290 ! erythromycin cation relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:48960 name: bis(azo) compound namespace: chebi_ontology def: "Any azo compound containing two -N=N- groups." [] subset: 3_STAR synonym: "bis(azo) compounds" RELATED [ChEBI] is_a: CHEBI:37533 ! azo compound [Term] id: CHEBI:48975 name: substituted aniline namespace: chebi_ontology subset: 3_STAR synonym: "substituted anilines" RELATED [ChEBI] is_a: CHEBI:22562 ! anilines [Term] id: CHEBI:49020 name: hormone antagonist namespace: chebi_ontology def: "A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." [] subset: 3_STAR synonym: "hormone antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist is_a: CHEBI:51061 ! hormone receptor modulator [Term] id: CHEBI:49103 name: drug metabolite namespace: chebi_ontology subset: 3_STAR synonym: "drug metabolites" RELATED [ChEBI] is_a: CHEBI:76967 ! human xenobiotic metabolite [Term] id: CHEBI:49167 name: anti-asthmatic drug namespace: chebi_ontology def: "A drug used to treat asthma." [] subset: 3_STAR synonym: "anti-asthmatic agent" RELATED [ChEBI] synonym: "anti-asthmatic agents" RELATED [ChEBI] synonym: "anti-asthmatic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:65023 ! anti-asthmatic agent [Term] id: CHEBI:49318 name: piperidine antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:26151 ! piperidines [Term] id: CHEBI:49319 name: carbocyclic antibiotic namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33598 ! carbocyclic compound relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:49637 name: hydrogen atom namespace: chebi_ontology alt_id: CHEBI:24634 alt_id: CHEBI:49636 subset: 3_STAR synonym: "1H" RELATED [IUPAC] synonym: "H" RELATED [IUPAC] synonym: "hidrogeno" RELATED [ChEBI] synonym: "hydrogen" RELATED [ChEBI] synonym: "hydrogene" RELATED [ChEBI] synonym: "Wasserstoff" RELATED [ChEBI] xref: WebElements:H is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33559 ! s-block element atom relationship: RO:0000087 CHEBI:33937 ! has role macronutrient [Term] id: CHEBI:4998 name: fenarimol namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union." [] subset: 3_STAR synonym: "(+-)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol" RELATED [ChemIDplus] synonym: "(+-)-fenarimol" RELATED [HMDB] synonym: "(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol" RELATED [NIST_Chemistry_WebBook] synonym: "(RS)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol" RELATED [Alan_Wood's_Pesticides] synonym: "2,4'-dichloro-alpha(pyrimidin-5-yl)benzhydryl alcohol" RELATED [NIST_Chemistry_WebBook] synonym: "alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol" RELATED [Alan_Wood's_Pesticides] synonym: "fenarimol" EXACT [ChEBI] synonym: "rac-(R)-(2-chlorophenyl)(4-chlorophenyl)(pyrimidin-5-yl)methanol" RELATED [Alan_Wood's_Pesticides] synonym: "rac-fenarimol" RELATED [ChEBI] xref: HMDB:HMDB0040599 xref: KEGG:C11226 xref: Patent:US3818009 xref: Patent:US3869456 xref: Patent:US3887708 xref: Wikipedia:Fenarimol is_a: CHEBI:60911 ! racemate is_a: CHEBI:87207 ! pyrimidine fungicide relationship: BFO:0000051 CHEBI:83688 ! has part (R)-fenarimol relationship: BFO:0000051 CHEBI:83689 ! has part (S)-fenarimol relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:50010 name: 4,4'-bis(\{4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl\}amino)stilbene-2,2'-disulfonic acid namespace: chebi_ontology def: "An organosulfonic acid comprising stilbene having 4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino groups at the 4 and 4'-positions and sulfo groups at the 2- and 2'-positions." [] subset: 3_STAR synonym: "4,4'-bis((4-(bis(2-hydroxyethyl)amino)-6-anilino-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonic acid" RELATED [ChemIDplus] synonym: "4,4'-bis((4-anilino-6-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulfonic acid" RELATED [ChemIDplus] synonym: "4,4'-bis((4-anilino-6-(bis(2-hydroxyethyl)amino)-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid" RELATED [ChemIDplus] synonym: "C.I. Fluorescent brightening agent 28" RELATED [ChemIDplus] synonym: "Calcofluor M2R" RELATED [ChemIDplus] synonym: "Calcofluor White M2R" RELATED [ChemIDplus] is_a: CHEBI:26588 ! 1,3,5-triazines is_a: CHEBI:33551 ! organosulfonic acid relationship: has_parent_hydride CHEBI:26775 ! stilbene relationship: is_conjugate_acid_of CHEBI:50012 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonate relationship: RO:0000087 CHEBI:51217 ! has role fluorochrome [Term] id: CHEBI:50011 name: Calcofluor White namespace: chebi_ontology subset: 3_STAR synonym: "4,4'-bis((2-anilino-4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-6-yl)amino)stilbene-2,2'-disulfonic acid, disodium salt" RELATED [ChemIDplus] synonym: "4,4'-bis((4-anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid, disodium salt" RELATED [ChemIDplus] synonym: "C.I. 40622" RELATED [ChEBI] synonym: "C.I. Fluorescent Brightening Agent 28, disodium salt" RELATED [ChemIDplus] synonym: "Calcofluor White LRP" RELATED [ChemIDplus] synonym: "Calcofluor White M 2R" RELATED [ChemIDplus] synonym: "Calcofluor White ST" RELATED [ChemIDplus] synonym: "Cellufluor" RELATED [ChemIDplus] synonym: "disodium 4,4'-bis(6-anilino-(4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonate" RELATED [ChemIDplus] synonym: "Fluorescent Brightener 28" RELATED [ChemIDplus] is_a: CHEBI:38700 ! organic sodium salt relationship: BFO:0000051 CHEBI:50012 ! has part 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonate [Term] id: CHEBI:50012 name: 4,4'-bis(\{4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl\}amino)stilbene-2,2'-disulfonate namespace: chebi_ontology def: "An arenesulfonate arising from deprotonation of the sulfo groups of 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonic acid." [] subset: 3_STAR is_a: CHEBI:22713 ! arenesulfonate oxoanion relationship: has_parent_hydride CHEBI:26775 ! stilbene relationship: is_conjugate_base_of CHEBI:50010 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonic acid [Term] id: CHEBI:50047 name: organic amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "organic amino compounds" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:16134 ! ammonia relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base [Term] id: CHEBI:50103 name: excitatory amino acid agonist namespace: chebi_ontology def: "An agent that binds to and activates excitatory amino acid receptors." [] subset: 3_STAR synonym: "excitatory amino acid agonists" RELATED [ChEBI] synonym: "excitatory amino acid receptor agonist" RELATED [ChEBI] synonym: "excitatory amino acid receptor agonists" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:50160 name: steroid acid anion namespace: chebi_ontology def: "Any anion formed by loss of a proton from a steroid acid." [] subset: 3_STAR synonym: "steroid acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid [Term] id: CHEBI:50176 name: keratolytic drug namespace: chebi_ontology def: "A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases." [] subset: 3_STAR synonym: "desquamating agent" RELATED [ChEBI] synonym: "keratolytic agent" RELATED [ChEBI] synonym: "keratolytic drugs" RELATED [ChEBI] synonym: "skin-peeling agent" RELATED [ChEBI] is_a: CHEBI:50177 ! dermatologic drug [Term] id: CHEBI:50177 name: dermatologic drug namespace: chebi_ontology def: "A drug used to treat or prevent skin disorders or for the routine care of skin." [] subset: 3_STAR synonym: "dermatologic agent" RELATED [ChEBI] synonym: "dermatologic drugs" RELATED [ChEBI] synonym: "dermatological agent" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50183 name: P450 inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances." [] subset: 3_STAR synonym: "CYP2D6 inhibitor" RELATED [ChEBI] synonym: "CYP2D6 inhibitors" RELATED [ChEBI] synonym: "cytochrome P450 inhibitor" RELATED [ChEBI] synonym: "cytochrome P450 inhibitors" RELATED [ChEBI] synonym: "P450 inhibitors" RELATED [ChEBI] is_a: CHEBI:76898 ! EC 1.14.14.1 (unspecific monooxygenase) inhibitor [Term] id: CHEBI:50185 name: fatty acid synthesis inhibitor namespace: chebi_ontology def: "Any pathway inhibitor that inhibits the synthesis of fatty acids." [] subset: 3_STAR synonym: "fatty acid synthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:50247 name: antidote namespace: chebi_ontology def: "Any protective agent counteracting or neutralizing the action of poisons." [] subset: 3_STAR synonym: "antidotes" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:50248 name: hematologic agent namespace: chebi_ontology def: "Drug that acts on blood and blood-forming organs and those that affect the hemostatic system." [] subset: 3_STAR synonym: "hematologic agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50249 name: anticoagulant namespace: chebi_ontology def: "An agent that prevents blood clotting." [] subset: 3_STAR synonym: "anticoagulante" RELATED [ChEBI] synonym: "anticoagulants" RELATED [ChEBI] is_a: CHEBI:50248 ! hematologic agent [Term] id: CHEBI:50266 name: prodrug namespace: chebi_ontology def: "A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug." [] subset: 3_STAR synonym: "Prodrugs" RELATED [ChEBI] xref: Wikipedia:Prodrug is_a: CHEBI:136859 ! pro-agent is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50267 name: protective agent namespace: chebi_ontology def: "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." [] subset: 3_STAR synonym: "chemoprotectant" RELATED [ChEBI] synonym: "chemoprotectants" RELATED [ChEBI] synonym: "chemoprotective agent" RELATED [ChEBI] synonym: "chemoprotective agents" RELATED [ChEBI] synonym: "protective agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50276 name: EC 5.99.1.2 (DNA topoisomerase) inhibitor namespace: chebi_ontology def: "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." [] subset: 3_STAR synonym: "DNA topoisomerase inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.2 (DNA topoisomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.2 (topoisomerase I) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.2 (topoisomerase I) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.2 inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.2 inhibitors" RELATED [ChEBI] synonym: "topoisomerase I (EC 5.99.1.2) inhibitor" RELATED [ChEBI] synonym: "topoisomerase I (EC 5.99.1.2) inhibitors" RELATED [ChEBI] synonym: "topoisomerase I inhibitor" RELATED [ChEBI] synonym: "topoisomerase I inhibitors" RELATED [ChEBI] synonym: "type I DNA topoisomerase inhibitor" RELATED [ChEBI] synonym: "type I DNA topoisomerase inhibitors" RELATED [ChEBI] is_a: CHEBI:70727 ! topoisomerase inhibitor [Term] id: CHEBI:50297 name: canonical nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical nucleotide residues" RELATED [ChEBI] is_a: CHEBI:50319 ! nucleotide residue [Term] id: CHEBI:50299 name: canonical ribonucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "canonical ribonucleotide residues" RELATED [ChEBI] is_a: CHEBI:50297 ! canonical nucleotide residue [Term] id: CHEBI:50312 name: onium compound namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:37577 ! heteroatomic molecular entity [Term] id: CHEBI:50313 name: onium cation namespace: chebi_ontology def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." [] subset: 3_STAR synonym: "onium cations" RELATED [ChEBI] synonym: "onium ion" RELATED [ChEBI] synonym: "onium ions" RELATED [ChEBI] is_a: CHEBI:50312 ! onium compound [Term] id: CHEBI:50315 name: chloronium namespace: chebi_ontology subset: 3_STAR synonym: "[ClH2](+)" RELATED [IUPAC] synonym: "H2Cl(+)" RELATED [IUPAC] is_a: CHEBI:50313 ! onium cation relationship: is_conjugate_acid_of CHEBI:17883 ! hydrogen chloride [Term] id: CHEBI:50319 name: nucleotide residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleotide residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50320 name: nucleoside residue namespace: chebi_ontology subset: 3_STAR synonym: "nucleoside residues" RELATED [ChEBI] is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:50325 name: proteinogenic amino-acid side-chain group namespace: chebi_ontology def: "A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid." [] subset: 3_STAR synonym: "canonical amino-acid side-chain" RELATED [ChEBI] synonym: "canonical amino-acid side-chains" RELATED [ChEBI] synonym: "proteinogenic amino-acid side-chain" RELATED [ChEBI] synonym: "proteinogenic amino-acid side-chain groups" RELATED [ChEBI] synonym: "proteinogenic amino-acid side-chains" RELATED [ChEBI] is_a: CHEBI:33249 ! organyl group [Term] id: CHEBI:50335 name: organic nitrogen anion namespace: chebi_ontology subset: 3_STAR synonym: "organic nitrogen anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:50344 name: avermectin namespace: chebi_ontology def: "Any of the macrolides obtained as fermentation products from the bacterium Streptomyces avermitilis and consisting of a 16-membered macrocyclic backbone that is fused both benzofuran and spiroketal functions and contains a disaccharide substituent. They have significant anthelmintic and insecticidal properties." [] subset: 3_STAR synonym: "avermectin" EXACT [ChEBI] synonym: "avermectins" RELATED [ChEBI] xref: Wikipedia:Avermectin is_a: CHEBI:25106 ! macrolide is_a: CHEBI:59779 ! cyclic ketal relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:50346 name: emamectins namespace: chebi_ontology subset: 3_STAR synonym: "emamectin" RELATED [ChEBI] is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:50406 name: probe namespace: chebi_ontology def: "A role played by a molecular entity used to study the microscopic environment." [] subset: 3_STAR is_a: CHEBI:33232 ! application [Term] id: CHEBI:50471 name: primary arylamine namespace: chebi_ontology def: "A primary amine formally derived from ammonia by replacing one hydrogen atom by an aryl group. R-NH2 where R is an aryl group." [] subset: 3_STAR synonym: "an arylamine" RELATED [UniProt] synonym: "primary arylamine" EXACT [ChEBI] is_a: CHEBI:32877 ! primary amine is_a: CHEBI:33860 ! aromatic amine [Term] id: CHEBI:50492 name: thiocarbonyl compound namespace: chebi_ontology def: "Any compound containing the thiocarbonyl group, C=S." [] subset: 3_STAR synonym: "thiocarbonyl compounds" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound relationship: BFO:0000051 CHEBI:30256 ! has part thiocarbonyl group [Term] id: CHEBI:50525 name: phenolate anion namespace: chebi_ontology def: "An organic anion arising from deprotonation of the OH function of a phenol compound." [] subset: 3_STAR synonym: "phenolate anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion [Term] id: CHEBI:50533 name: protein denaturant namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33232 ! application [Term] id: CHEBI:50584 name: alkyl alcohol namespace: chebi_ontology alt_id: CHEBI:22937 alt_id: CHEBI:50581 def: "An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position." [] subset: 3_STAR synonym: "alkyl alcohols" RELATED [ChEBI] synonym: "hydroxyalkane" RELATED [ChEBI] synonym: "hydroxyalkanes" RELATED [ChEBI] is_a: CHEBI:2571 ! aliphatic alcohol [Term] id: CHEBI:50635 name: EC 3.5.1.5 (urease) inhibitor namespace: chebi_ontology def: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of urease (EC 3.5.1.5), reducing hydrolysis." [] subset: 3_STAR synonym: "EC 3.5.1.5 (urease) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.5 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.5 inhibitors" RELATED [ChEBI] synonym: "urea amidohydrolase inhibitor" RELATED [ChEBI] synonym: "urea amidohydrolase inhibitors" RELATED [ChEBI] synonym: "urease (EC 3.5.1.5) inhibitor" RELATED [ChEBI] synonym: "urease (EC 3.5.1.5) inhibitors" RELATED [ChEBI] synonym: "urease inhibitor" RELATED [ChEBI] synonym: "urease inhibitors" RELATED [ChEBI] is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:50658 name: ampicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "ampicillinate" RELATED [ChEBI] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:28971 ! ampicillin [Term] id: CHEBI:50683 name: EC 1.5.1.3 (dihydrofolate reductase) inhibitor namespace: chebi_ontology def: "An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3)." [] subset: 3_STAR synonym: "7,8-dihydrofolate reductase inhibitor" RELATED [ChEBI] synonym: "7,8-dihydrofolate reductase inhibitors" RELATED [ChEBI] synonym: "DHFR inhibitor" RELATED [ChEBI] synonym: "DHFR inhibitors" RELATED [ChEBI] synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitor" RELATED [ChEBI] synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitors" RELATED [ChEBI] synonym: "dihydrofolate reductase inhibitor" RELATED [ChEBI] synonym: "dihydrofolate reductase inhibitors" RELATED [ChEBI] synonym: "dihydrofolic acid reductase inhibitor" RELATED [ChEBI] synonym: "dihydrofolic acid reductase inhibitors" RELATED [ChEBI] synonym: "dihydrofolic reductase inhibitor" RELATED [ChEBI] synonym: "dihydrofolic reductase inhibitors" RELATED [ChEBI] synonym: "EC 1.5.1.3 (dihydrofolate reductase) inhibitors" RELATED [ChEBI] synonym: "EC 1.5.1.3 inhibitor" RELATED [ChEBI] synonym: "EC 1.5.1.3 inhibitors" RELATED [ChEBI] synonym: "folic acid reductase inhibitor" RELATED [ChEBI] synonym: "folic acid reductase inhibitors" RELATED [ChEBI] synonym: "folic reductase inhibitor" RELATED [ChEBI] synonym: "folic reductase inhibitors" RELATED [ChEBI] synonym: "NADPH-dihydrofolate reductase inhibitor" RELATED [ChEBI] synonym: "NADPH-dihydrofolate reductase inhibitors" RELATED [ChEBI] synonym: "tetrahydrofolate dehydrogenase inhibitor" RELATED [ChEBI] synonym: "tetrahydrofolate dehydrogenase inhibitors" RELATED [ChEBI] xref: Wikipedia:Dihydrofolate_reductase_inhibitor is_a: CHEBI:73913 ! antifolate is_a: CHEBI:76863 ! EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor [Term] id: CHEBI:50685 name: antitrichomonal drug namespace: chebi_ontology def: "A drug used to treat trichomonas infections." [] subset: 3_STAR synonym: "antitrichomonal agent" RELATED [ChEBI] is_a: CHEBI:35820 ! antiprotozoal drug [Term] id: CHEBI:50694 name: minocycline namespace: chebi_ontology alt_id: CHEBI:44053 alt_id: CHEBI:6939 def: "A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5." [] subset: 3_STAR synonym: "(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" RELATED [PDBeChem] synonym: "7-Dimethylamino-6-demethyl-6-deoxytetracycline" RELATED [ChemIDplus] synonym: "Minocycline" EXACT [KEGG_COMPOUND] synonym: "minomycin" RELATED [ChEBI] xref: Chemspider:16735907 xref: DrugBank:DB01017 xref: HMDB:HMDB0015152 xref: KEGG:C07225 xref: KEGG:D05045 xref: KNApSAcK:C00018686 xref: Patent:US3226436 xref: Patent:WO2008104734 xref: PDBeChem:MIY is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone is_a: CHEBI:26895 ! tetracyclines is_a: CHEBI:48132 ! tetracenomycin relationship: is_conjugate_acid_of CHEBI:71337 ! minocycline(1-) relationship: is_tautomer_of CHEBI:77906 ! minocycline zwitterion relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:50695 name: monobactam namespace: chebi_ontology def: "Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotic. It lacks the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized." [] subset: 3_STAR synonym: "monobactams" RELATED [ChEBI] is_a: CHEBI:27933 ! beta-lactam antibiotic [Term] id: CHEBI:50696 name: EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of peptidoglycan glycosyltransferase (EC 2.4.1.129)." [] subset: 3_STAR synonym: "[poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitor" RELATED [ChEBI] synonym: "[poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitors" RELATED [ChEBI] synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.129 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.129 inhibitors" RELATED [ChEBI] synonym: "PBP3 inhibitor" RELATED [ChEBI] synonym: "penicillin binding protein 1B inhibitor" RELATED [ChEBI] synonym: "penicillin binding protein 1B inhibitors" RELATED [ChEBI] synonym: "penicillin binding protein 3 inhibitor" RELATED [ChEBI] synonym: "penicillin binding protein 3 inhibitors" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitor" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitors" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase inhibitor" RELATED [ChEBI] synonym: "peptidoglycan glycosyltransferase inhibitors" RELATED [ChEBI] synonym: "peptidoglycan transglycosylase inhibitor" RELATED [ChEBI] synonym: "peptidoglycan transglycosylase inhibitors" RELATED [ChEBI] synonym: "PG-II inhibitor" RELATED [ChEBI] synonym: "PG-II inhibitors" RELATED [ChEBI] synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitor" RELATED [ChEBI] synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor [Term] id: CHEBI:50699 name: oligosaccharide namespace: chebi_ontology alt_id: CHEBI:25679 alt_id: CHEBI:35319 alt_id: CHEBI:7758 def: "A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues." [] subset: 3_STAR synonym: "O-glycosylglycoside" RELATED [ChEBI] synonym: "O-glycosylglycosides" RELATED [ChEBI] synonym: "oligosacarido" RELATED [ChEBI] synonym: "oligosacaridos" RELATED [IUPAC] synonym: "Oligosaccharide" EXACT [KEGG_COMPOUND] xref: KEGG:C00930 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan [Term] id: CHEBI:50733 name: nutraceutical namespace: chebi_ontology def: "A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance." [] subset: 3_STAR synonym: "Dietary Supplement" RELATED [ChEBI] synonym: "Food Supplementation" RELATED [ChEBI] synonym: "Nutritional supplement" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:50750 name: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor namespace: chebi_ontology alt_id: CHEBI:132229 alt_id: CHEBI:50234 def: "A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." [] subset: 3_STAR synonym: "DNA gyrase inhibitor" RELATED [ChEBI] synonym: "DNA gyrase inhibitors" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitors" RELATED [ChEBI] synonym: "DNA topoisomerase II inhibitor" RELATED [ChEBI] synonym: "DNA topoisomerase II inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.3 inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.3 inhibitors" RELATED [ChEBI] synonym: "inhibitor of type II topoisomerase" RELATED [ChEBI] synonym: "inhibitors of type II topoisomerase" RELATED [ChEBI] synonym: "topoisomerase II inhibitor" RELATED [ChEBI] synonym: "topoisomerase II inhibitors" RELATED [ChEBI] synonym: "topoisomerase-II inhibitor" RELATED [ChEBI] synonym: "topoisomerase-II inhibitors" RELATED [ChEBI] synonym: "type II DNA topoisomerase inhibitor" RELATED [ChEBI] synonym: "type II DNA topoisomerase inhibitors" RELATED [ChEBI] is_a: CHEBI:70727 ! topoisomerase inhibitor [Term] id: CHEBI:50845 name: doxycycline namespace: chebi_ontology alt_id: CHEBI:42135 alt_id: CHEBI:4713 def: "Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis." [] subset: 3_STAR synonym: "(4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" RELATED [PDBeChem] synonym: "5-hydroxy-alpha-6-deoxytetracycline" RELATED [ChemIDplus] synonym: "6alpha-deoxy-5-oxytetracycline" RELATED [ChemIDplus] synonym: "Doxycyclin" RELATED [ChEBI] synonym: "Doxycycline" EXACT [KEGG_COMPOUND] synonym: "doxycycline (anhydrous)" RELATED [ChemIDplus] xref: Chemspider:10469369 xref: DrugBank:DB00254 xref: HMDB:HMDB0014399 xref: KEGG:C06973 xref: KEGG:D07876 xref: KNApSAcK:C00017127 xref: MetaCyc:CPD-19256 xref: Patent:US3019260 xref: Patent:US3200149 xref: PDBeChem:DXT xref: VSDB:1840 xref: Wikipedia:Doxycycline is_a: CHEBI:26895 ! tetracyclines relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:38068 ! has role antimalarial relationship: RO:0000087 CHEBI:50846 ! has role immunomodulator relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent [Term] id: CHEBI:50846 name: immunomodulator namespace: chebi_ontology def: "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." [] subset: 3_STAR synonym: "Biomodulator" RELATED [ChEBI] synonym: "Immune factor" RELATED [ChEBI] synonym: "Immunologic factor" RELATED [ChEBI] synonym: "Immunological factor" RELATED [ChEBI] synonym: "immunomodulators" RELATED [ChEBI] xref: Wikipedia:Immunotherapy is_a: CHEBI:23888 ! drug is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:50847 name: immunological adjuvant namespace: chebi_ontology def: "A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity." [] subset: 3_STAR synonym: "Immunoactivator" RELATED [ChEBI] synonym: "Immunoadjuvant" RELATED [ChEBI] synonym: "Immunologic adjuvant" RELATED [ChEBI] synonym: "Immunopotentiator" RELATED [ChEBI] synonym: "Immunostimulant" RELATED [ChEBI] xref: Wikipedia:Immunologic_adjuvant is_a: CHEBI:50846 ! immunomodulator is_a: CHEBI:60809 ! adjuvant [Term] id: CHEBI:50860 name: organic molecular entity namespace: chebi_ontology alt_id: CHEBI:25700 alt_id: CHEBI:33244 def: "Any molecular entity that contains carbon." [] subset: 3_STAR synonym: "organic compounds" RELATED [ChEBI] synonym: "organic entity" RELATED [ChEBI] synonym: "organic molecular entities" RELATED [ChEBI] is_a: CHEBI:33582 ! carbon group molecular entity relationship: BFO:0000051 CHEBI:27594 ! has part carbon atom [Term] id: CHEBI:50893 name: azaarene namespace: chebi_ontology subset: 3_STAR synonym: "azaarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:50902 name: genotoxin namespace: chebi_ontology def: "A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells." [] subset: 3_STAR synonym: "genotoxic agent" RELATED [ChEBI] synonym: "genotoxic agents" RELATED [ChEBI] synonym: "genotoxins" RELATED [ChEBI] xref: Wikipedia:Genotoxicity is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50903 name: carcinogenic agent namespace: chebi_ontology def: "A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities." [] subset: 3_STAR synonym: "agente carcinogeno" RELATED [ChEBI] synonym: "cancerigene" RELATED [ChEBI] synonym: "cancerogene" RELATED [ChEBI] synonym: "carcinogen" RELATED [ChEBI] synonym: "carcinogene" RELATED [ChEBI] synonym: "carcinogenic agents" RELATED [ChEBI] synonym: "carcinogeno" RELATED [ChEBI] synonym: "carcinogens" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50904 name: allergen namespace: chebi_ontology def: "A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy." [] subset: 3_STAR synonym: "alergeno" RELATED [ChEBI] synonym: "allergene" RELATED [ChEBI] synonym: "allergenic agent" RELATED [ChEBI] xref: Wikipedia:Allergen is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50906 name: role namespace: chebi_ontology def: "A role is particular behaviour which a material entity may exhibit." [] subset: 3_STAR [Term] id: CHEBI:50908 name: hepatotoxic agent namespace: chebi_ontology def: "A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals." [] subset: 3_STAR synonym: "agente hepatotoxico" RELATED [ChEBI] synonym: "hepatotoxic agents" RELATED [ChEBI] synonym: "hepatotoxicant" RELATED [ChEBI] synonym: "hepatotoxicants" RELATED [ChEBI] synonym: "hepatotoxin" RELATED [ChEBI] synonym: "hepatotoxins" RELATED [ChEBI] synonym: "hepatoxic agent" RELATED [ChEBI] synonym: "hepatoxicant" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50909 name: nephrotoxic agent namespace: chebi_ontology def: "A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys." [] subset: 3_STAR synonym: "agente nefrotoxico" RELATED [ChEBI] synonym: "nephrotoxic agents" RELATED [ChEBI] synonym: "nephrotoxicant" RELATED [ChEBI] is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50910 name: neurotoxin namespace: chebi_ontology alt_id: CHEBI:50911 def: "A poison that interferes with the functions of the nervous system." [] subset: 3_STAR synonym: "agente neurotoxico" RELATED [ChEBI] synonym: "nerve poison" RELATED [ChEBI] synonym: "nerve poisons" RELATED [ChEBI] synonym: "neurotoxic agent" RELATED [ChEBI] synonym: "neurotoxic agents" RELATED [ChEBI] synonym: "neurotoxicant" RELATED [ChEBI] synonym: "neurotoxins" RELATED [ChEBI] xref: Wikipedia:Neurotoxin is_a: CHEBI:52209 ! aetiopathogenetic role is_a: CHEBI:64909 ! poison [Term] id: CHEBI:50994 name: primary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." [] subset: 3_STAR synonym: "primary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion [Term] id: CHEBI:50995 name: secondary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "secondary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:50996 name: tertiary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups." [] subset: 3_STAR synonym: "tertiary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:137982 ! tertiary ammonium ion [Term] id: CHEBI:5100 name: flucytosine namespace: chebi_ontology def: "An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections." [] subset: 3_STAR synonym: "5-FC" RELATED [KEGG_DRUG] synonym: "5-Fluorocystosine" RELATED [ChemIDplus] synonym: "5-Fluorocytosine" RELATED [ChemIDplus] synonym: "Ancobon (TN)" RELATED [KEGG_DRUG] xref: DrugBank:DB01099 xref: HMDB:HMDB0015231 xref: KEGG:D00323 xref: LINCS:LSM-5878 xref: Patent:US2802005 xref: Patent:US2945038 xref: Patent:US3040026 xref: PDBeChem:1LD xref: Wikipedia:Flucytosine is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38337 ! pyrimidone is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:60783 ! nucleoside analogue is_a: CHEBI:87205 ! pyrimidine antifungal drug relationship: has_functional_parent CHEBI:16040 ! cytosine relationship: RO:0000087 CHEBI:50266 ! has role prodrug [Term] id: CHEBI:51026 name: macrocycle namespace: chebi_ontology def: "A cyclic compound containing nine or more atoms as part of the cyclic system." [] subset: 3_STAR synonym: "macrocycles" RELATED [ChEBI] synonym: "Makrocyclen" RELATED [ChEBI] synonym: "makrocyclische Verbindungen" RELATED [ChEBI] synonym: "Makrozyklen" RELATED [ChEBI] synonym: "makrozyklische Verbindungen" RELATED [ChEBI] xref: Wikipedia:Macrocycle is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:51061 name: hormone receptor modulator namespace: chebi_ontology def: "A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." [] subset: 3_STAR synonym: "hormone receptor modulators" RELATED [ChEBI] is_a: CHEBI:90710 ! receptor modulator [Term] id: CHEBI:51086 name: chemical role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a chemical context." [] subset: 3_STAR is_a: CHEBI:50906 ! role [Term] id: CHEBI:51121 name: fluorescent dye namespace: chebi_ontology subset: 3_STAR synonym: "fluorescent dyes" RELATED [ChEBI] is_a: CHEBI:37958 ! dye [Term] id: CHEBI:51143 name: nitrogen molecular entity namespace: chebi_ontology alt_id: CHEBI:25556 alt_id: CHEBI:7594 subset: 3_STAR synonym: "nitrogen compounds" RELATED [ChEBI] synonym: "nitrogen molecular entities" RELATED [ChEBI] synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND] xref: KEGG:C06061 is_a: CHEBI:33302 ! pnictogen molecular entity relationship: BFO:0000051 CHEBI:25555 ! has part nitrogen atom [Term] id: CHEBI:51144 name: nitrogen group namespace: chebi_ontology subset: 3_STAR synonym: "nitrogen group" EXACT [ChEBI] synonym: "nitrogen groups" RELATED [ChEBI] synonym: "nitrogen-containing group" RELATED [ChEBI] synonym: "nitrogenous group" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:51151 name: dipolar compound namespace: chebi_ontology def: "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." [] subset: 3_STAR synonym: "dipolar compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:51208 name: mecillinam namespace: chebi_ontology def: "A penicillin in which the 6beta substituent is [(azepan-1-yl)methylidene]amino; an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "amdinocillin" RELATED [ChemIDplus] synonym: "penicillin HX" RELATED [ChemIDplus] xref: DrugBank:DB01163 xref: LINCS:LSM-5528 xref: Patent:DE2055531 xref: Patent:US3957764 is_a: CHEBI:17334 ! penicillin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:51217 name: fluorochrome namespace: chebi_ontology def: "A fluorescent dye used to stain biological specimens." [] subset: 3_STAR synonym: "fluorochromes" RELATED [ChEBI] is_a: CHEBI:51121 ! fluorescent dye [Term] id: CHEBI:51256 name: amoxicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:2676 ! amoxicillin [Term] id: CHEBI:51269 name: acenes namespace: chebi_ontology def: "Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives." [] subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound [Term] id: CHEBI:51270 name: tetracenes namespace: chebi_ontology def: "Compounds containing a tetracene skeleton." [] subset: 3_STAR synonym: "naphthacenes" RELATED [ChEBI] is_a: CHEBI:51269 ! acenes [Term] id: CHEBI:51276 name: thioureas namespace: chebi_ontology def: "Compounds of general formula RR'NC(=S)NR''R'''." [] subset: 3_STAR is_a: CHEBI:50492 ! thiocarbonyl compound [Term] id: CHEBI:51308 name: dinitrile namespace: chebi_ontology def: "A dinitrile is a compound containing two nitrile groups." [] subset: 3_STAR synonym: "dinitrile" EXACT [ChEBI] synonym: "dinitriles" RELATED [ChEBI] is_a: CHEBI:18379 ! nitrile [Term] id: CHEBI:51336 name: metal sulfate namespace: chebi_ontology def: "Sulfate salts where the cation is a metal ion." [] subset: 3_STAR synonym: "metal sulfates" RELATED [ChEBI] is_a: CHEBI:24840 ! inorganic sulfate salt [Term] id: CHEBI:51337 name: organic sulfate salt namespace: chebi_ontology subset: 3_STAR synonym: "organic sulfate salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:35175 ! sulfate salt [Term] id: CHEBI:51354 name: benzylpenicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "penicillin G" RELATED [UniProt] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:18208 ! benzylpenicillin [Term] id: CHEBI:51356 name: penicillinate anion namespace: chebi_ontology alt_id: CHEBI:58108 def: "Any anion formed by loss of a proton from the carboxy group of a penicillin." [] subset: 3_STAR synonym: "a penicillin" RELATED [UniProt] synonym: "penicillin anion" RELATED [ChEBI] synonym: "penicillin anions" RELATED [ChEBI] is_a: CHEBI:47811 ! penamcarboxylate relationship: is_conjugate_base_of CHEBI:17334 ! penicillin [Term] id: CHEBI:51373 name: GABA agonist namespace: chebi_ontology def: "A drug that binds to and activates gamma-aminobutyric acid receptors." [] subset: 3_STAR synonym: "GABA agonists" RELATED [ChEBI] synonym: "GABA receptor agonist" RELATED [ChEBI] synonym: "GABA receptor agonists" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor agonist" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor agonists" RELATED [ChEBI] is_a: CHEBI:51374 ! GABA agent [Term] id: CHEBI:51374 name: GABA agent namespace: chebi_ontology def: "A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems." [] subset: 3_STAR is_a: CHEBI:35942 ! neurotransmitter agent [Term] id: CHEBI:51402 name: phenylenediamine namespace: chebi_ontology def: "A benzene substituted with two amino groups." [] subset: 3_STAR synonym: "diaminobenzene" RELATED [ChEBI] is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:35410 ! primary diamine [Term] id: CHEBI:51422 name: organodiyl group namespace: chebi_ontology def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." [] subset: 3_STAR synonym: "organodiyl groups" RELATED [ChEBI] is_a: CHEBI:51446 ! organic divalent group [Term] id: CHEBI:51446 name: organic divalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51447 name: organic univalent group namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group [Term] id: CHEBI:51454 name: cyclopropanes namespace: chebi_ontology def: "Cyclopropane and its derivatives formed by substitution." [] subset: 3_STAR is_a: CHEBI:33598 ! carbocyclic compound [Term] id: CHEBI:51683 name: methoxybenzenes namespace: chebi_ontology def: "Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups." [] subset: 3_STAR synonym: "methoxybenzene" RELATED [ChEBI] is_a: CHEBI:22712 ! benzenes is_a: CHEBI:35618 ! aromatic ether [Term] id: CHEBI:51689 name: enone namespace: chebi_ontology def: "An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position." [] subset: 3_STAR synonym: "enones" RELATED [ChEBI] xref: Wikipedia:Enone is_a: CHEBI:51721 ! alpha,beta-unsaturated ketone is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:51702 name: enoate ester namespace: chebi_ontology def: "An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position." [] subset: 3_STAR synonym: "enoate" RELATED [ChEBI] synonym: "enoate esters" RELATED [ChEBI] synonym: "enoates" RELATED [ChEBI] is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:51721 name: alpha,beta-unsaturated ketone namespace: chebi_ontology def: "A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] subset: 3_STAR synonym: "alpha,beta-unsaturated ketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:51737 name: alpha,beta-unsaturated carboxylic ester namespace: chebi_ontology def: "A carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) or R(1)C#C-C(=O)OR(2) (R(2) =/= H) in which the ester C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] subset: 3_STAR synonym: "alpha,beta-unsaturated carboxylic esters" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester [Term] id: CHEBI:51750 name: alpha,beta-unsaturated carboxylic acid amide namespace: chebi_ontology def: "A monocarboxylic amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) or R(1)C#C-C(=O)NR(2)R(3) in which the amide C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] subset: 3_STAR synonym: "alpha,beta-unsaturated amide" RELATED [ChEBI] synonym: "alpha,beta-unsaturated carboxamide" RELATED [ChEBI] synonym: "alpha,beta-unsaturated monocarboxylic acid amide" RELATED [ChEBI] synonym: "alpha,beta-unsaturated monocarboxylic acid amides" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:51751 name: enamide namespace: chebi_ontology def: "An alpha,beta-unsaturated carboxylic acid amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) in which the amide C=O function is conjugated to a C=C double bond at the alpha,beta position." [] subset: 3_STAR synonym: "enamides" RELATED [ChEBI] is_a: CHEBI:51750 ! alpha,beta-unsaturated carboxylic acid amide is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:51811 name: ticarcillin(2-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:9587 ! ticarcillin [Term] id: CHEBI:51867 name: methyl ketone namespace: chebi_ontology def: "A ketone of formula RC(=O)CH3 (R =/= H)." [] subset: 3_STAR synonym: "methyl ketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone [Term] id: CHEBI:51897 name: carbenicillin(2-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-{[carboxylato(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:3393 ! carbenicillin [Term] id: CHEBI:5195 name: furazolidone namespace: chebi_ontology def: "A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera." [] subset: 3_STAR synonym: "3-(5'-Nitrofurfuralamino)-2-oxazolidone" RELATED [ChemIDplus] synonym: "3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone" RELATED [ChemIDplus] synonym: "3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone" RELATED [ChemIDplus] synonym: "3-[(5-Nitrofurylidene)amino]-2-oxazolidone" RELATED [ChemIDplus] synonym: "3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone" RELATED [ChemIDplus] synonym: "5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine" RELATED [NIST_Chemistry_WebBook] synonym: "Furazolidone" EXACT [KEGG_COMPOUND] synonym: "Furoxone" RELATED [KEGG_DRUG] synonym: "FZL" RELATED [ChEBI] synonym: "N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone" RELATED [ChemIDplus] synonym: "N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one" RELATED [ChemIDplus, NIST_Chemistry_WebBook] synonym: "Nitrofurazolidone" RELATED [DrugBank] synonym: "Nitrofurazolidonum" RELATED [DrugBank] xref: DrugBank:DB00614 xref: HMDB:HMDB0014752 xref: KEGG:C07999 xref: KEGG:D00830 xref: LINCS:LSM-6543 xref: Patent:GB735136 xref: Patent:US2742462 xref: Patent:US2759931 xref: Patent:US2927110 xref: Wikipedia:Furazolidone is_a: CHEBI:38329 ! oxazolidines is_a: CHEBI:87230 ! nitrofuran antibiotic relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:38623 ! has role EC 1.4.3.4 (monoamine oxidase) inhibitor relationship: RO:0000087 CHEBI:50685 ! has role antitrichomonal drug [Term] id: CHEBI:51958 name: organic polycyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound [Term] id: CHEBI:51959 name: organic tricyclic compound namespace: chebi_ontology subset: 3_STAR synonym: "organic tricyclic compounds" RELATED [ChEBI] is_a: CHEBI:51958 ! organic polycyclic compound [Term] id: CHEBI:52017 name: dicloxacillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:4511 ! dicloxacillin [Term] id: CHEBI:52064 name: methicillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [IUPAC] synonym: "6beta-(2,6-dimethoxybenzamido)penicillanate" RELATED [ChEBI] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:6827 ! methicillin [Term] id: CHEBI:52090 name: methoxide namespace: chebi_ontology def: "An organic anion that is the conjugate base of methanol." [] subset: 3_STAR synonym: "methoxide ion" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:17790 ! methanol relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:52132 name: oxacillin(1-) namespace: chebi_ontology subset: 3_STAR synonym: "6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanate" RELATED [ChEBI] is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:7809 ! oxacillin [Term] id: CHEBI:52206 name: biochemical role namespace: chebi_ontology def: "A biological role played by the molecular entity or part thereof within a biochemical context." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52208 name: biophysical role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52209 name: aetiopathogenetic role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." [] subset: 3_STAR synonym: "etiopathogenetic agent" RELATED [ChEBI] synonym: "etiopathogenetic role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52210 name: pharmacological role namespace: chebi_ontology def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." [] subset: 3_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52211 name: physiological role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:52214 name: ligand namespace: chebi_ontology def: "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." [] subset: 3_STAR synonym: "ligands" RELATED [ChEBI] xref: Wikipedia:Ligand is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:52217 name: pharmaceutical namespace: chebi_ontology alt_id: CHEBI:33293 alt_id: CHEBI:33294 def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." [] subset: 3_STAR synonym: "farmaco" RELATED [ChEBI] synonym: "medicament" RELATED [ChEBI] synonym: "pharmaceuticals" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:52362 name: ortho-fused heteroarene namespace: chebi_ontology def: "An ortho-fused compound in which at least one of the rings contains at least one heteroatom." [] subset: 3_STAR synonym: "ortho-fused heteroarenes" RELATED [ChEBI] is_a: CHEBI:33637 ! ortho-fused compound is_a: CHEBI:38180 ! polycyclic heteroarene [Term] id: CHEBI:52433 name: piperacillin(1-) namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:51356 ! penicillinate anion relationship: is_conjugate_base_of CHEBI:8232 ! piperacillin [Term] id: CHEBI:52440 name: cephalosporin carboxylic acid anion namespace: chebi_ontology subset: 3_STAR synonym: "cephalosporin carboxylate" RELATED [ChEBI] synonym: "cephalosporin carboxylates" RELATED [ChEBI] synonym: "cephalosporin carboxylic acid anions" RELATED [ChEBI] synonym: "cephalosporincarboxylate" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion [Term] id: CHEBI:52492 name: mancozeb namespace: chebi_ontology def: "A mixture composed from maneb and zineb, which is used as a broad-spectrum contact fungicide." [] subset: 3_STAR synonym: "ethylenebis(dithiocarbamic acid) manganese zinc complex" RELATED [ChemIDplus] synonym: "Mancozeb" EXACT [KEGG_COMPOUND] xref: KEGG:C15225 xref: Wikipedia:Mancozeb is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:52497 ! has part maneb relationship: BFO:0000051 CHEBI:52498 ! has part zineb relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:52497 name: maneb namespace: chebi_ontology def: "A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab." [] subset: 3_STAR synonym: "manganese ethane-1,2-diyldicarbamodithioate" RELATED [IUPAC] xref: KEGG:C15231 xref: PPDB:426 xref: Wikipedia:Maneb is_a: CHEBI:60027 ! polymer relationship: BFO:0000051 CHEBI:35117 ! has part manganese coordination entity relationship: BFO:0000051 CHEBI:83060 ! has part dithiocarbamate salt relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:52498 name: zineb namespace: chebi_ontology def: "A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU." [] subset: 3_STAR synonym: "zinc ethane-1,2-diyldicarbamodithioate" RELATED [IUPAC] xref: KEGG:C15232 xref: Patent:CN1648120 xref: Patent:US2690448 xref: PPDB:683 xref: Wikipedia:Zineb is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:36566 ! zinc coordination entity is_a: CHEBI:83060 ! dithiocarbamate salt relationship: BFO:0000051 CHEBI:77308 ! has part ethylenebis(dithiocarbamate) relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:52549 name: sordarin namespace: chebi_ontology def: "An antifungal metabolite of Sordaria araneosa that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure." [] subset: 3_STAR synonym: "Antibiotic SL-2266" RELATED [ChemIDplus] synonym: "sordarin B" RELATED [SUBMITTER] is_a: CHEBI:24400 ! glycoside is_a: CHEBI:52557 ! tetracyclic diterpenoid is_a: CHEBI:63367 ! monosaccharide derivative relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor [Term] id: CHEBI:52557 name: tetracyclic diterpenoid namespace: chebi_ontology def: "A diterpenoid with a tetracyclic skeleton." [] subset: 3_STAR synonym: "tetracyclic diterpenoids" RELATED [ChEBI] is_a: CHEBI:23849 ! diterpenoid [Term] id: CHEBI:52646 name: leptomycin B namespace: chebi_ontology def: "A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17." [] subset: 3_STAR synonym: "antibiotic ATS 1287B" RELATED [ChEBI] synonym: "Antibiotic CI 940" RELATED [ChemIDplus] synonym: "Antibiotic CL 1957A" RELATED [ChemIDplus] synonym: "Antibiotic PD 114720" RELATED [ChEBI] synonym: "ATS 1287B" RELATED [ChEBI] synonym: "LMB" RELATED [ChEBI] is_a: CHEBI:140345 ! hydroxy polyunsaturated fatty acid is_a: CHEBI:52651 ! leptomycin relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:52651 name: leptomycin namespace: chebi_ontology def: "A complex, very long chain, polyunsaturated fatty acid whose core structure comprises 8-oxononadeca-2,10,12,16,18-pentaenoic acid having methyl substituents at positions 3, 5, 7, 9, 11 and 15 and a 3,6-dihydropyran-6-one-2-yl group at position 19." [] subset: 3_STAR synonym: "leptomycins" RELATED [ChEBI] is_a: CHEBI:24654 ! hydroxy fatty acid is_a: CHEBI:25000 ! lactone is_a: CHEBI:26208 ! polyunsaturated fatty acid is_a: CHEBI:27283 ! very long-chain fatty acid is_a: CHEBI:35819 ! branched-chain fatty acid is_a: CHEBI:59644 ! oxo fatty acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid relationship: has_functional_parent CHEBI:28866 ! tetracosanoic acid [Term] id: CHEBI:52726 name: proteasome inhibitor namespace: chebi_ontology def: "A drug that blocks the action of proteasomes, cellular complexes that break down proteins." [] subset: 3_STAR synonym: "proteasome inhibitors" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:5280 name: gatifloxacin namespace: chebi_ontology alt_id: CHEBI:101712 def: "A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes." [] subset: 3_STAR synonym: "1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid" RELATED [ChEMBL] synonym: "AM 1155" RELATED [KEGG_COMPOUND] xref: DrugBank:DB01044 xref: KEGG:C07661 xref: KEGG:D08011 xref: LINCS:LSM-5139 xref: Patent:EP230295 xref: Patent:US4980470 xref: Wikipedia:Gatifloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:86324 ! quinolone antibiotic relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor [Term] id: CHEBI:52898 name: azamacrocycle namespace: chebi_ontology def: "A cyclic macromolecule containing one or more nitrogen atoms in place of carbon either as the divalent group NH for the group CH2 or a single trivalent nitrogen atom for the group CH." [] subset: 3_STAR synonym: "aza macrocycle" RELATED [SUBMITTER] synonym: "aza macrocyclic compound" RELATED [SUBMITTER] synonym: "aza-macrocycle" RELATED [SUBMITTER] synonym: "azamacrocycles" RELATED [ChEBI] is_a: CHEBI:51026 ! macrocycle [Term] id: CHEBI:53000 name: epitope namespace: chebi_ontology def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." [] subset: 3_STAR synonym: "antigenic determinant" RELATED [ChEBI] synonym: "epitope function" RELATED [ChEBI] synonym: "epitope role" RELATED [ChEBI] is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:53559 name: topoisomerase IV inhibitor namespace: chebi_ontology def: "A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." [] subset: 3_STAR synonym: "topoisomerase IV inhibitors" RELATED [ChEBI] is_a: CHEBI:70727 ! topoisomerase inhibitor [Term] id: CHEBI:53628 name: 2,6-dideoxy-alpha-D-glucoside namespace: chebi_ontology def: "An alpha-D-glucoside deoxygenated at C-2 and C-6." [] subset: 3_STAR is_a: CHEBI:22390 ! alpha-D-glucoside [Term] id: CHEBI:53634 name: neomycin C namespace: chebi_ontology def: "A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine C." [] subset: 3_STAR xref: KEGG:C15652 is_a: CHEBI:47779 ! aminoglycoside relationship: is_conjugate_base_of CHEBI:65077 ! neomycin C(6+) [Term] id: CHEBI:53655 name: cefoxitin(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion having methoxy, 2-thienylacetamido and carbamoyloxymethyl side-groups, formed by proton loss from the carboxy group of the semisynthetic cephamycin antibiotic cefoxitin." [] subset: 3_STAR synonym: "(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:209807 ! cefoxitin [Term] id: CHEBI:53657 name: cefazolin(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups, formed by proton loss from the carboxy group of cefazolin." [] subset: 3_STAR synonym: "(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:474053 ! cefazolin [Term] id: CHEBI:53658 name: ceftriaxone(1-) namespace: chebi_ontology def: "A cephalosporin carboxylis acid anion having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups, formed by proton loss from the carboxy group of ceftriaxone." [] subset: 3_STAR xref: MetaCyc:CPD-12294 is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:29007 ! ceftriaxone [Term] id: CHEBI:53661 name: alexidine namespace: chebi_ontology def: "An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge." [] subset: 3_STAR synonym: "1,1'-Hexamethylenebis(5-(2-ethylhexyl)biguanide)" RELATED [ChemIDplus] synonym: "bisguadine" RELATED [ChEBI] synonym: "N,N'-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide" RELATED [ChemIDplus] xref: LINCS:LSM-4432 xref: Patent:CN101624356 xref: Wikipedia:Alexidine is_a: CHEBI:53662 ! biguanides relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:53662 name: biguanides namespace: chebi_ontology alt_id: CHEBI:35529 def: "A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton." [] subset: 3_STAR is_a: CHEBI:24436 ! guanidines relationship: RO:0000087 CHEBI:35526 ! has role hypoglycemic agent [Term] id: CHEBI:53665 name: oxazinoquinoline namespace: chebi_ontology def: "Any organic heterotricyclic compound based on a skeleton comprised of an oxazine ring fused onto a quinoline system." [] subset: 3_STAR synonym: "oxazinoquinolines" RELATED [ChEBI] is_a: CHEBI:26979 ! organic heterotricyclic compound [Term] id: CHEBI:53670 name: cefotaxime(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups, formed by proton loss from the carboxy group of the cephalosporin cefotaxime." [] subset: 3_STAR synonym: "(6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:204928 ! cefotaxime [Term] id: CHEBI:53676 name: ceftazidime(1-) namespace: chebi_ontology def: "A cephalosporin carboxylic acid anion formed by proton loss from the carboxy group of ceftazidime, a cephalosporin having 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino and 3-pyridinium-1-ylmethyl side-groups." [] subset: 3_STAR synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxylatopropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [IUPAC] is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:3508 ! ceftazidime [Term] id: CHEBI:5385 name: gliotoxin namespace: chebi_ontology def: "A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi." [] subset: 3_STAR synonym: "Aspergillin" RELATED [ChemIDplus] xref: KEGG:C10595 xref: KNApSAcK:C00002340 xref: PPDB:2793 xref: Wikipedia:Gliotoxin is_a: CHEBI:35489 ! organic disulfide is_a: CHEBI:38163 ! organic heterotetracyclic compound is_a: CHEBI:46761 ! dipeptide is_a: CHEBI:64130 ! pyrazinoindole relationship: RO:0000087 CHEBI:25442 ! has role mycotoxin relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:52726 ! has role proteasome inhibitor relationship: RO:0000087 CHEBI:64133 ! has role EC 2.5.1.58 (protein farnesyltransferase) inhibitor [Term] id: CHEBI:5435 name: piperidine-2,6-dione namespace: chebi_ontology def: "A dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6." [] subset: 3_STAR synonym: "2,6-Diketopiperidine" RELATED [KEGG_COMPOUND] synonym: "2,6-piperidinedione" RELATED [ChemIDplus] synonym: "Glutarimide" RELATED [KEGG_COMPOUND] synonym: "Piperidine-2,6-dione" EXACT [KEGG_COMPOUND] xref: KEGG:C07275 is_a: CHEBI:35356 ! dicarboximide is_a: CHEBI:48589 ! piperidones [Term] id: CHEBI:5530 name: gramicidin S namespace: chebi_ontology subset: 3_STAR synonym: "Cyclo(L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl)" RELATED [ChemIDplus] synonym: "gramicidin" RELATED [ChEBI] synonym: "Gramicidin C" RELATED [ChemIDplus] synonym: "Gramicidin S" EXACT [KEGG_COMPOUND] synonym: "Gramicin S 1" RELATED [ChemIDplus] synonym: "Gramicin S-A" RELATED [ChEBI] xref: KEGG:C11218 is_a: CHEBI:24613 ! homodetic cyclic peptide [Term] id: CHEBI:55346 name: anidulafungin namespace: chebi_ontology def: "A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis." [] subset: 3_STAR xref: DrugBank:DB00362 xref: KEGG:D03211 xref: Wikipedia:Anidulafungin is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:52898 ! azamacrocycle is_a: CHEBI:57248 ! echinocandin is_a: CHEBI:72588 ! semisynthetic derivative is_a: CHEBI:87113 ! antibiotic antifungal drug [Term] id: CHEBI:55370 name: imidazolidinone namespace: chebi_ontology def: "An imidazolidine containing one or more oxo groups." [] subset: 3_STAR synonym: "imidazolidinones" RELATED [ChEBI] is_a: CHEBI:38261 ! imidazolidines [Term] id: CHEBI:55373 name: isoxazoles namespace: chebi_ontology alt_id: CHEBI:46813 def: "Oxazoles in which the N and O atoms are adjacent." [] subset: 3_STAR synonym: "1,2-oxazoles" RELATED [ChEBI] synonym: "isoxazoles" EXACT [ChEBI] is_a: CHEBI:35790 ! oxazole [Term] id: CHEBI:55374 name: oxazolidinone namespace: chebi_ontology def: "An oxazolidine containing one or more oxo groups." [] subset: 3_STAR synonym: "oxazolidinedione" RELATED [ChEBI] synonym: "oxazolidinediones" RELATED [ChEBI] synonym: "oxazolidinones" RELATED [ChEBI] is_a: CHEBI:38329 ! oxazolidines [Term] id: CHEBI:55429 name: cephamycin namespace: chebi_ontology def: "Any member of the cephamycin sub-group of cephem antibiotics, differing from cephalosporins in possessing a methoxy group at the 7alpha-position of the cephem nucleus, and in being resistant to beta-lactamase." [] subset: 3_STAR synonym: "cephamycins" RELATED [ChEBI] is_a: CHEBI:38311 ! cephem [Term] id: CHEBI:55517 name: trichothecene namespace: chebi_ontology def: "Any one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain." [] subset: 3_STAR synonym: "trichothecenes" RELATED [ChEBI] is_a: CHEBI:26658 ! sesquiterpenoid is_a: CHEBI:32955 ! epoxide is_a: CHEBI:38166 ! organic heteropolycyclic compound relationship: RO:0000087 CHEBI:25442 ! has role mycotoxin [Term] id: CHEBI:5653 name: hemiacetal namespace: chebi_ontology def: "A compound having the general formula RR'C(OH)OR'' (R'' =/= H)." [] subset: 3_STAR synonym: "Hemiacetal" EXACT [KEGG_COMPOUND] synonym: "hemiacetals" RELATED [ChEBI] is_a: CHEBI:30879 ! alcohol [Term] id: CHEBI:5686 name: heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of at least two different elements." [] subset: 3_STAR synonym: "compuesto heterociclico" RELATED [IUPAC] synonym: "compuestos heterociclicos" RELATED [IUPAC] synonym: "heterocycle" RELATED [ChEBI] synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND] synonym: "heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:57248 name: echinocandin namespace: chebi_ontology def: "Any one of a family of large lipopeptides that are inhibitors of the enzyme 1,3-beta-glucan synthase, thus damaging fungal cell walls. Echinocandins are fungicidal against most Candida spp and fungistatic against Aspergillus spp." [] subset: 3_STAR synonym: "echinocandins" RELATED [ChEBI] is_a: CHEBI:46895 ! lipopeptide is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: RO:0000087 CHEBI:230471 ! has role EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitor [Term] id: CHEBI:57726 name: D-proline zwitterion namespace: chebi_ontology def: "A D-alpha-amino acid zwitterion that is D-proline in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." [] subset: 3_STAR synonym: "D-proline" RELATED [UniProt] xref: MetaCyc:D-PROLINE is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion relationship: is_tautomer_of CHEBI:16313 ! D-proline [Term] id: CHEBI:57869 name: 6-aminopenicillanic acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of 6-aminopenicillanic acid arising from migration of a proton from the carboxy group to the 6-amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-azaniumyl-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [ChEBI] synonym: "6-aminopenicillanate" RELATED [UniProt] is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_conjugate_acid_of CHEBI:30938 ! 6-aminopenicillanate relationship: is_tautomer_of CHEBI:16705 ! 6-aminopenicillanic acid [Term] id: CHEBI:57971 name: hygromycin B(3+) namespace: chebi_ontology def: "An ammonium ion that is the trication of hygromycin B arising from protonation of the three amino groups; major species at pH 7.3." [] subset: 3_STAR synonym: "hygromycin B" RELATED [UniProt] synonym: "hygromycin B trication" RELATED [ChEBI] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:16976 ! hygromycin B [Term] id: CHEBI:58007 name: streptomycin(3+) namespace: chebi_ontology def: "Trication of streptomycin arising from protonation of the guanidino and secondary amino groups." [] subset: 3_STAR synonym: "streptomycin" RELATED [UniProt] synonym: "streptomycin trication" RELATED [ChEBI] is_a: CHEBI:60251 ! guanidinium ion relationship: is_conjugate_acid_of CHEBI:17076 ! streptomycin [Term] id: CHEBI:58165 name: 3',5'-cyclic AMP(1-) namespace: chebi_ontology def: "An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3." [] subset: 3_STAR synonym: "3',5'-cyclic AMP" RELATED [UniProt] synonym: "3',5'-cyclic AMP anion" RELATED [ChEBI] synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [ChEBI] synonym: "adenosine 3',5'-cyclic monophosphate anion" RELATED [ChEBI] synonym: "adenosine 3',5'-cyclic monophosphate(1-)" RELATED [ChEBI] is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:17489 ! 3',5'-cyclic AMP relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite [Term] id: CHEBI:582124 name: myriocin namespace: chebi_ontology def: "An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity." [] subset: 3_STAR synonym: "(2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid" RELATED [ChEBI] synonym: "(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid" RELATED [ChEBI] synonym: "antibiotic ISP-1" RELATED [ChEBI] synonym: "antibiotic ISP-I" RELATED [ChEBI] synonym: "ISP-1" RELATED [KEGG_COMPOUND] synonym: "ISP-I" RELATED [ChEBI] synonym: "thermozymocidin" RELATED [ChemIDplus] xref: KEGG:C19914 xref: KNApSAcK:C00016936 xref: PDBeChem:VRP xref: Wikipedia:Myriocin is_a: CHEBI:35785 ! sphingoid is_a: CHEBI:35868 ! hydroxy monocarboxylic acid is_a: CHEBI:59755 ! alpha-amino fatty acid relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:59647 ! has role EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite [Term] id: CHEBI:58214 name: kanamycin A(4+) namespace: chebi_ontology def: "A quadruply-charged organic cation arising from protonation of the four amino groups of kanamycin A; major species at pH 7.3." [] subset: 3_STAR synonym: "kanamycin A" RELATED [UniProt] synonym: "kanamycin A tetracation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:17630 ! kanamycin A relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:5827 name: hymexazol namespace: chebi_ontology def: "A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces, Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals." [] subset: 3_STAR synonym: "3-Hydroxy-5-methylisoxazole" RELATED [ChemIDplus] synonym: "5-Methyl-3(2H)-isoxazolone" RELATED [ChemIDplus] synonym: "5-Methyl-3-hydroxyisoxazole" RELATED [ChemIDplus] synonym: "5-Methylisoxazol-3-ol" RELATED [ChemIDplus] synonym: "F 319" RELATED [ChemIDplus] synonym: "F-319" RELATED [ChemIDplus] synonym: "Hydroxyisoxazole" RELATED [ChemIDplus] synonym: "Hymexazole" RELATED [ChemIDplus] synonym: "NSC 217971" RELATED [ChemIDplus] synonym: "SF-6505" RELATED [ChemIDplus] xref: KEGG:C11103 xref: PPDB:388 is_a: CHEBI:55373 ! isoxazoles is_a: CHEBI:74818 ! heteroaryl hydroxy compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:58464 name: nucleoside 3',5'-cyclic phosphate anion namespace: chebi_ontology def: "The conjugate base of a nucleoside 3',5'-cyclic phosphate." [] subset: 3_STAR synonym: "a nucleoside 3',5'-cyclic phosphate" RELATED [UniProt] synonym: "nucleoside 3',5'-cyclic phosphate anions" RELATED [ChEBI] is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate [Term] id: CHEBI:58549 name: kanamycin B(5+) namespace: chebi_ontology def: "An organic cation that is the pentacation of kanamycin B, obtained by protonation of the primary amino groups." [] subset: 3_STAR synonym: "kanamycin B" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28098 ! kanamycin B [Term] id: CHEBI:58942 name: cationic amino-acid residue namespace: chebi_ontology def: "An amino-acid residue protonated on nitrogen." [] subset: 3_STAR synonym: "amino acid cation residue" RELATED [ChEBI] synonym: "amino acid cation residues" RELATED [ChEBI] synonym: "amino-acid cation residue" RELATED [ChEBI] synonym: "amino-acid cation residues" RELATED [ChEBI] synonym: "cationic amino acid residue" RELATED [ChEBI] synonym: "cationic amino acid residues" RELATED [ChEBI] synonym: "cationic amino-acid residues" RELATED [ChEBI] is_a: CHEBI:64769 ! organic cationic group relationship: is_conjugate_acid_of CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:58945 name: organophosphate oxoanion namespace: chebi_ontology def: "An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated." [] subset: 3_STAR synonym: "organophosphate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:26079 ! phosphoric acid derivative [Term] id: CHEBI:58950 name: very long-chain fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion with a chain length greater than C22." [] subset: 3_STAR synonym: "a very long-chain fatty acid" RELATED [UniProt] synonym: "very long-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:27283 ! very long-chain fatty acid [Term] id: CHEBI:58951 name: short-chain fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6)." [] subset: 3_STAR synonym: "a short-chain fatty acid" RELATED [UniProt] synonym: "short-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:26666 ! short-chain fatty acid [Term] id: CHEBI:58953 name: saturated fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion in which there is no C-C unsaturation." [] subset: 3_STAR synonym: "saturated fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion [Term] id: CHEBI:58954 name: straight-chain saturated fatty acid anion namespace: chebi_ontology def: "Any saturated fatty acid anion lacking a carbon side-chain." [] subset: 3_STAR synonym: "straight-chain saturated fatty acid anions" RELATED [ChEBI] is_a: CHEBI:58953 ! saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:39418 ! straight-chain saturated fatty acid [Term] id: CHEBI:58955 name: branched-chain fatty acid anion namespace: chebi_ontology def: "Any fatty acid anion with a carbon side-chain or isopropyl termination." [] subset: 3_STAR synonym: "branched-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:35819 ! branched-chain fatty acid [Term] id: CHEBI:58958 name: organosulfate oxoanion namespace: chebi_ontology def: "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." [] subset: 3_STAR synonym: "organosulfate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:33482 ! sulfur oxoanion relationship: has_functional_parent CHEBI:16189 ! sulfate relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate [Term] id: CHEBI:59062 name: polymyxin namespace: chebi_ontology def: "Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria." [] subset: 3_STAR synonym: "polymixin" RELATED [ChEBI] synonym: "polymycin" RELATED [ChEBI] synonym: "polymyxins" RELATED [ChEBI] is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:46895 ! lipopeptide relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:59064 name: colistin A namespace: chebi_ontology def: "A polymyxin having a (6R)-6-methyloctanoyl group at the amino terminus." [] subset: 3_STAR synonym: "Colistin A" EXACT [ChemIDplus] synonym: "Colistin IV" RELATED [ChemIDplus] synonym: "Polymixin E1" RELATED [ChemIDplus] synonym: "Polymyxin E1" RELATED [ChemIDplus] is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:59062 ! polymyxin [Term] id: CHEBI:59066 name: oxolinate namespace: chebi_ontology def: "Conjugate base of oxolinic acid." [] subset: 3_STAR synonym: "5-ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylate" RELATED [IUPAC] is_a: CHEBI:38773 ! quinolinemonocarboxylate relationship: is_conjugate_base_of CHEBI:138856 ! oxolinic acid [Term] id: CHEBI:59107 name: EC 3.4.24.* (metalloendopeptidase) inhibitor namespace: chebi_ontology alt_id: CHEBI:76786 def: "Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*)." [] subset: 3_STAR synonym: "EC 3.4.24.* (metalloendopeptidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.* inhibitor" RELATED [ChEBI] synonym: "EC 3.4.24.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of metalloendopeptidases" RELATED [ChEBI] synonym: "inhibitor of metalloendopeptidases (EC 3.4.24.*)" RELATED [ChEBI] synonym: "inhibitors of metalloendopeptidases" RELATED [ChEBI] synonym: "inhibitors of metalloendopeptidases (EC 3.4.24.*)" RELATED [ChEBI] synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitor" RELATED [ChEBI] synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitors" RELATED [ChEBI] synonym: "metalloendopeptidase inhibitors" RELATED [ChEBI] is_a: CHEBI:37670 ! protease inhibitor [Term] id: CHEBI:59163 name: biomarker namespace: chebi_ontology def: "A substance used as an indicator of a biological state." [] subset: 3_STAR synonym: "biological marker" RELATED [ChEBI] is_a: CHEBI:47867 ! indicator [Term] id: CHEBI:59202 name: straight-chain fatty acid namespace: chebi_ontology def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." [] subset: 3_STAR synonym: "straight-chain fatty acids" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:59203 ! straight-chain fatty acid anion [Term] id: CHEBI:59203 name: straight-chain fatty acid anion namespace: chebi_ontology def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." [] subset: 3_STAR synonym: "straight-chain FA anion" RELATED [ChEBI] synonym: "straight-chain FA anions" RELATED [ChEBI] synonym: "straight-chain fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:59202 ! straight-chain fatty acid [Term] id: CHEBI:59285 name: EC 1.14.13.132 (squalene monooxygenase) inhibitor namespace: chebi_ontology def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132)." [] subset: 3_STAR synonym: "EC 1.14.13.132 (squalene monooxygenase) inhibitors" RELATED [ChEBI] synonym: "squalene 2,3-oxidocyclase inhibitor" RELATED [ChEBI] synonym: "squalene 2,3-oxidocyclase inhibitors" RELATED [ChEBI] synonym: "squalene epoxidase inhibitor" RELATED [ChEBI] synonym: "squalene epoxidase inhibitors" RELATED [ChEBI] synonym: "squalene hydroxylase inhibitor" RELATED [ChEBI] synonym: "squalene hydroxylase inhibitors" RELATED [ChEBI] synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitor" RELATED [ChEBI] synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitors" RELATED [ChEBI] synonym: "squalene monooxygenase inhibitor" RELATED [ChEBI] synonym: "squalene monooxygenase inhibitors" RELATED [ChEBI] synonym: "squalene oxydocyclase inhibitor" RELATED [ChEBI] synonym: "squalene oxydocyclase inhibitors" RELATED [ChEBI] synonym: "squalene-2,3-epoxidase inhibitor" RELATED [ChEBI] synonym: "squalene-2,3-epoxidase inhibitors" RELATED [ChEBI] synonym: "squalene-2,3-epoxide cyclase inhibitor" RELATED [ChEBI] synonym: "squalene-2,3-epoxide cyclase inhibitors" RELATED [ChEBI] is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor [Term] id: CHEBI:59349 name: cefepime(1+) namespace: chebi_ontology def: "The conjugate acid of cefepime." [] subset: 3_STAR synonym: "cefepime conjugate acid" RELATED [ChEBI] is_a: CHEBI:23066 ! cephalosporin relationship: is_conjugate_acid_of CHEBI:478164 ! cefepime [Term] id: CHEBI:59358 name: cefotetan(2-) namespace: chebi_ontology def: "The dianion formed by removal of a proton from each of the carboxylic acid groups of cefotetan." [] subset: 3_STAR synonym: "cefotetan dianion" RELATED [ChEBI] is_a: CHEBI:28965 ! dicarboxylic acid dianion relationship: is_conjugate_base_of CHEBI:3499 ! cefotetan [Term] id: CHEBI:59392 name: cephalexin(1-) namespace: chebi_ontology def: "The anion resulting from the removal of a proton from the carboxylic acid group of cephalexin." [] subset: 3_STAR synonym: "cefalexin anion" RELATED [ChEBI] synonym: "cefalexin(1-)" RELATED [ChEBI] synonym: "cephalexin anion" RELATED [ChEBI] is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion relationship: is_conjugate_base_of CHEBI:3534 ! cephalexin [Term] id: CHEBI:59517 name: DNA synthesis inhibitor namespace: chebi_ontology def: "Any substance that inhibits the synthesis of DNA." [] subset: 3_STAR synonym: "DNA synthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:76932 ! pathway inhibitor [Term] id: CHEBI:59635 name: organophosphonate oxoanion namespace: chebi_ontology def: "An organic phosphonic acid derivative in which one or more oxygen atoms of the phosphonate group(s) has been deprotonated." [] subset: 3_STAR synonym: "organophosphonate oxoanions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives [Term] id: CHEBI:59644 name: oxo fatty acid namespace: chebi_ontology def: "Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group." [] subset: 3_STAR synonym: "oxo fatty acids" RELATED [ChEBI] is_a: CHEBI:25754 ! oxo carboxylic acid is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:59836 ! oxo fatty acid anion [Term] id: CHEBI:59647 name: EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of serine palmitoyltransferase (EC 2.3.1.50)." [] subset: 3_STAR synonym: "3-oxosphinganine synthetase inhibitor" RELATED [ChEBI] synonym: "3-oxosphinganine synthetase inhibitors" RELATED [ChEBI] synonym: "acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitor" RELATED [ChEBI] synonym: "acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.50 inhibitor" RELATED [ChEBI] synonym: "EC 2.3.1.50 inhibitors" RELATED [ChEBI] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitor" RELATED [ChEBI] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitors" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase (EC 2.3.1.50) inhibitor" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase (EC 2.3.1.50) inhibitors" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase inhibitor" RELATED [ChEBI] synonym: "serine C-palmitoyltransferase inhibitors" RELATED [ChEBI] synonym: "serine palmitoyltransferase inhibitor" RELATED [ChEBI] synonym: "serine palmitoyltransferase inhibitors" RELATED [ChEBI] synonym: "SPT inhibitor" RELATED [ChEBI] synonym: "SPT inhibitors" RELATED [ChEBI] xref: Wikipedia:Serine_C-palmitoyltransferase is_a: CHEBI:76878 ! EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor [Term] id: CHEBI:59650 name: amino fatty acid namespace: chebi_ontology def: "A fatty acid containing at least one amino substituent." [] subset: 3_STAR synonym: "amino FA" RELATED [ChEBI] synonym: "amino fatty acids" RELATED [ChEBI] synonym: "carboxylated base" RELATED [ChEBI] synonym: "carboxylated bases" RELATED [ChEBI] synonym: "lipoamino acid" RELATED [ChEBI] synonym: "lipoamino acids" RELATED [ChEBI] is_a: CHEBI:32952 ! amine is_a: CHEBI:33709 ! amino acid is_a: CHEBI:60690 ! nitrogen-containing fatty acid relationship: is_conjugate_acid_of CHEBI:61007 ! amino fatty acid anion [Term] id: CHEBI:59668 name: nikkomycin namespace: chebi_ontology def: "A class of nucleoside-peptide antibiotics which inhibit fungal chitin biosynthesis by inhibiting chitin synthase. Generally consist of a heterocyclic moiety (usually a nucleobase), an amino hexuronic acid and an amino acid containing a pyridine ring." [] subset: 3_STAR synonym: "nikkomycins" RELATED [ChEBI] is_a: CHEBI:36988 ! 5'-deoxyribonucleoside relationship: RO:0000087 CHEBI:25605 ! has role nucleoside antibiotic relationship: RO:0000087 CHEBI:59672 ! has role EC 2.4.1.16 (chitin synthase) inhibitor [Term] id: CHEBI:59672 name: EC 2.4.1.16 (chitin synthase) inhibitor namespace: chebi_ontology def: "A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of chitin synthase (EC 2.4.1.16)." [] subset: 3_STAR synonym: "chitin synthase (EC 2.4.1.16) inhibitor" RELATED [ChEBI] synonym: "chitin synthase (EC 2.4.1.16) inhibitors" RELATED [ChEBI] synonym: "chitin synthase inhibitor" RELATED [ChEBI] synonym: "chitin synthase inhibitors" RELATED [ChEBI] synonym: "chitin synthesis inhibitor" RELATED [ChEBI] synonym: "chitin synthesis inhibitors" RELATED [ChEBI] synonym: "chitin synthetase inhibitor" RELATED [ChEBI] synonym: "chitin synthetase inhibitors" RELATED [ChEBI] synonym: "chitin-UDP acetyl-glucosaminyl transferase inhibitor" RELATED [ChEBI] synonym: "chitin-UDP acetyl-glucosaminyl transferase inhibitors" RELATED [ChEBI] synonym: "chitin-UDP N-acetylglucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "chitin-UDP N-acetylglucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.16 (chitin synthase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.16 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.16 inhibitors" RELATED [ChEBI] synonym: "trans-N-acetylglucosaminosylase inhibitor" RELATED [ChEBI] synonym: "trans-N-acetylglucosaminosylase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Chitin_synthase is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor [Term] id: CHEBI:59673 name: colistin B namespace: chebi_ontology def: "A polymyxin having a 6-methylheptanoyl group at the amino terminus." [] subset: 3_STAR synonym: "polymyxin E2" RELATED [ChEBI] is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:59062 ! polymyxin [Term] id: CHEBI:59676 name: nystatins namespace: chebi_ontology def: "A class of polyene antifungal antibiotics produced by Streptomyces noursei, and other Streptomyces species." [] subset: 3_STAR xref: Patent:US2832719 xref: Patent:US3517100 is_a: CHEBI:22507 ! aminoglycoside antibiotic is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26191 ! polyol is_a: CHEBI:36244 ! dicarboxylic acid monoester is_a: CHEBI:48121 ! polyene is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:59698 name: phosphoric acids namespace: chebi_ontology def: "Compounds containing one or more phosphoric acid units." [] subset: 3_STAR is_a: CHEBI:33457 ! phosphorus oxoacid [Term] id: CHEBI:59740 name: nucleophilic reagent namespace: chebi_ontology def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." [] subset: 3_STAR synonym: "nucleophile" RELATED [ChEBI] synonym: "nucleophiles" RELATED [ChEBI] synonym: "nucleophilic reagents" RELATED [ChEBI] is_a: CHEBI:33893 ! reagent is_a: CHEBI:39144 ! Lewis base [Term] id: CHEBI:59755 name: alpha-amino fatty acid namespace: chebi_ontology def: "A fatty acid with an amino substituent at position C-2." [] subset: 3_STAR synonym: "a-amino fatty acid" RELATED [ChEBI] synonym: "a-amino fatty acids" RELATED [ChEBI] synonym: "alpha-amino FA" RELATED [ChEBI] synonym: "alpha-amino fatty acids" RELATED [ChEBI] is_a: CHEBI:59650 ! amino fatty acid is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid [Term] id: CHEBI:59769 name: acetal namespace: chebi_ontology def: "An organooxygen compound having the structure RR'C(OR'')(OR''') (R'', R''' =/= H). Mixed acetals have R'' and R''' groups which differ." [] subset: 3_STAR synonym: "acetals" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:59770 name: cyclic acetal namespace: chebi_ontology def: "An acetal in the molecule of which the acetal carbon and one or both oxygen atoms thereon are members of a ring." [] subset: 3_STAR synonym: "cyclic acetals" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:59769 ! acetal [Term] id: CHEBI:59772 name: hemiketal namespace: chebi_ontology def: "A hemiacetal having the structure RR(1)C(OH)OR(2) (R, R(1), R(2) =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group." [] subset: 3_STAR synonym: "hemiketals" RELATED [ChEBI] is_a: CHEBI:5653 ! hemiacetal [Term] id: CHEBI:59777 name: ketal namespace: chebi_ontology def: "An acetal of formula R2C(OR)2 (R =/= H) derived from a ketone by replacement of the oxo group by two hydrocarbyloxy groups. The class name 'ketals', once abandoned by IUPAC, has been reinstated as a subclass of acetals." [] subset: 3_STAR synonym: "ketals" RELATED [ChEBI] is_a: CHEBI:59769 ! acetal [Term] id: CHEBI:59779 name: cyclic ketal namespace: chebi_ontology def: "A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring." [] subset: 3_STAR synonym: "cyclic ketals" RELATED [ChEBI] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:59777 ! ketal [Term] id: CHEBI:59780 name: cyclic hemiketal namespace: chebi_ontology def: "A hemiacetal having the structure R2C(OH)OR (R =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group. The term 'cyclic hemiketals', once abandoned by IUPAC, has been reinstated as a subclass of hemiacetals." [] subset: 3_STAR synonym: "cyclic hemiketals" RELATED [ChEBI] is_a: CHEBI:38131 ! lactol is_a: CHEBI:59772 ! hemiketal [Term] id: CHEBI:59792 name: thioacetal namespace: chebi_ontology def: "The sulfur analogue of 'acetal'. The term includes monothioacetals having the structure R2C(OR')(SR') (subclass monothioketals, R =/= H); and dithioacetals having the structure R2C(SR')2 (subclass dithioketals, R =/= H, R' =/= H)." [] subset: 3_STAR synonym: "thioacetals" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound [Term] id: CHEBI:59793 name: monothioacetal namespace: chebi_ontology def: "A thioacetal having the structure R2C(OR')(SR'). The term includes monothioketals, R =/= H, as a subclass." [] subset: 3_STAR synonym: "monothioacetals" RELATED [ChEBI] synonym: "thioacetal" RELATED [ChEBI] is_a: CHEBI:59792 ! thioacetal [Term] id: CHEBI:59814 name: L-alpha-amino acid anion namespace: chebi_ontology def: "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." [] subset: 3_STAR synonym: "L-alpha-amino carboxylate" RELATED [ChEBI] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:15705 ! L-alpha-amino acid [Term] id: CHEBI:59831 name: enyne namespace: chebi_ontology def: "An acetylenic and an olefinic compound containing a carbon chain that contains a carbon-carbon double bond and a carbon-carbon triple bond." [] subset: 3_STAR synonym: "enynes" RELATED [ChEBI] is_a: CHEBI:73474 ! acetylenic compound is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:59835 name: hydroxy fatty acid anion namespace: chebi_ontology def: "The conjugate base of any hydroxy fatty acid, formed by deprotonation of the carboxylic acid moiety." [] subset: 3_STAR synonym: "hydroxy fatty acid anions" RELATED [ChEBI] synonym: "OH-FA anion" RELATED [ChEBI] synonym: "OH-FA-anions" RELATED [ChEBI] synonym: "OH-fatty acid anion" RELATED [ChEBI] synonym: "OH-fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:24654 ! hydroxy fatty acid [Term] id: CHEBI:59836 name: oxo fatty acid anion namespace: chebi_ontology def: "A fatty acid anion carrying one or more oxo substituents" [] subset: 3_STAR synonym: "oxo fatty acid anions" RELATED [ChEBI] synonym: "oxo-FA anion" RELATED [ChEBI] synonym: "oxo-FA anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion is_a: CHEBI:35903 ! oxo carboxylic acid anion relationship: is_conjugate_base_of CHEBI:59644 ! oxo fatty acid [Term] id: CHEBI:59864 name: depigmentation drug namespace: chebi_ontology def: "Any drug used to depigment skin, normally by decreasing the excretion of melanin from melanocytes." [] subset: 3_STAR synonym: "depigmentation agent" RELATED [ChEBI] synonym: "depigmentation agents" RELATED [ChEBI] synonym: "depigmentation drugs" RELATED [ChEBI] synonym: "depigmentor" RELATED [ChEBI] synonym: "depigmentors" RELATED [ChEBI] is_a: CHEBI:23888 ! drug [Term] id: CHEBI:59869 name: L-alpha-amino acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group." [] subset: 3_STAR synonym: "an L-alpha-amino acid" RELATED [UniProt] synonym: "L-alpha-amino acid zwitterions" RELATED [ChEBI] is_a: CHEBI:78608 ! alpha-amino-acid zwitterion relationship: is_tautomer_of CHEBI:15705 ! L-alpha-amino acid [Term] id: CHEBI:59871 name: D-alpha-amino acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group." [] subset: 3_STAR synonym: "a D-alpha-amino acid" RELATED [UniProt] synonym: "D-alpha-amino acid zwitterions" RELATED [ChEBI] is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:16733 ! D-alpha-amino acid [Term] id: CHEBI:59999 name: chemical substance namespace: chebi_ontology def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." [] subset: 3_STAR synonym: "Chemische Substanz" RELATED [ChEBI] is_a: CHEBI:24431 ! chemical entity [Term] id: CHEBI:60004 name: mixture namespace: chebi_ontology def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." [] subset: 3_STAR synonym: "Mischung" RELATED [ChEBI] is_a: CHEBI:59999 ! chemical substance [Term] id: CHEBI:600103 name: daptomycin namespace: chebi_ontology alt_id: CHEBI:29570 alt_id: CHEBI:321017 alt_id: CHEBI:478132 alt_id: CHEBI:478255 def: "A polypeptide comprising N-decanoyltryptophan, asparagine, aspartic acid, threonine, glycine, ornithine, aspartic acid, D-alanine, aspartic acid, glycine, D-serine, threo-3-methylglutamic acid and 3-anthraniloylalanine (also known as kynurinine) coupled in sequence and lactonised by condensation of the carboxylic acid group of the 3-anthraniloylalanine with the alcohol group of the threonine residue." [] subset: 3_STAR synonym: "Daptomycin" EXACT [KEGG_COMPOUND] synonym: "daptomycin" EXACT [ChEMBL] synonym: "LY 146032" RELATED [ChemIDplus] synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone" RELATED [ChEBI] synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone" RELATED [ChemIDplus] xref: DrugBank:DB00080 xref: KEGG:C12013 xref: KEGG:D01080 xref: Wikipedia:Daptomycin is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25061 ! lipopeptide antibiotic is_a: CHEBI:25106 ! macrolide relationship: RO:0000087 CHEBI:140190 ! has role calcium-dependent antibiotics relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:60027 name: polymer namespace: chebi_ontology def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." [] subset: 3_STAR synonym: "Kunststoff" RELATED [ChEBI] synonym: "Polymer" EXACT [ChEBI] xref: Wikipedia:Polymer is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:33839 ! has part macromolecule [Term] id: CHEBI:60039 name: L-proline zwitterion namespace: chebi_ontology alt_id: CHEBI:58054 def: "The zwitterion formed from L-proline by proton transfer from the carboxy group to the ring nitrogen. It is the predominant species at physiological pH." [] subset: 3_STAR synonym: "L-proline" RELATED [UniProt] xref: MetaCyc:PRO is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:17203 ! L-proline [Term] id: CHEBI:600520 name: micafungin namespace: chebi_ontology alt_id: CHEBI:473847 alt_id: CHEBI:530001 alt_id: CHEBI:533643 alt_id: CHEBI:533785 def: "A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy." [] subset: 3_STAR synonym: "Mycamine" RELATED [ChemIDplus] xref: DrugBank:DB01141 xref: KEGG:D08218 is_a: CHEBI:57248 ! echinocandin is_a: CHEBI:87113 ! antibiotic antifungal drug [Term] id: CHEBI:60071 name: ertapenem(1-) namespace: chebi_ontology def: "The mono-anion resulting from the removal of a proton from one of the carboxyic acid groups of ertapenem." [] subset: 3_STAR is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:404903 ! ertapenem [Term] id: CHEBI:60240 name: divalent metal cation namespace: chebi_ontology def: "A metal cation with a valence of two." [] subset: 3_STAR synonym: "a divalent metal cation" RELATED [UniProt] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:64641 ! divalent inorganic cation [Term] id: CHEBI:60242 name: monovalent inorganic cation namespace: chebi_ontology def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." [] subset: 3_STAR synonym: "a monovalent cation" RELATED [UniProt] is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:60251 name: guanidinium ion namespace: chebi_ontology def: "R = C or H. The iminium ion resulting from the protonation of one of the imine nitrogens of guanidine or its derivatives." [] subset: 3_STAR synonym: "diaminomethaniminium ion" RELATED [ChEBI] synonym: "diaminomethaniminium ions" RELATED [ChEBI] synonym: "guanidinium ions" RELATED [ChEBI] is_a: CHEBI:35286 ! iminium ion [Term] id: CHEBI:60258 name: EC 3.4.* (hydrolases acting on peptide bond) inhibitor namespace: chebi_ontology alt_id: CHEBI:76763 def: "A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*)." [] subset: 3_STAR synonym: "EC 3.4.* (hydrolase acting on peptide bond) inhibitor" RELATED [ChEBI] synonym: "EC 3.4.* (hydrolase acting on peptide bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.* (hydrolases acting on peptide bond) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.* (peptidase) inhibitor" RELATED [ChEBI] synonym: "EC 3.4.* (peptidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.* inhibitor" RELATED [ChEBI] synonym: "EC 3.4.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI] synonym: "inhibitors of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI] synonym: "peptidase inhibitors" RELATED [ChEBI] synonym: "protease inhibitor" RELATED [ChEBI] synonym: "protease inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:6030 name: isoniazide namespace: chebi_ontology def: "A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine." [] subset: 3_STAR synonym: "4-pyridinecarbohydrazide" RELATED [ChEBI] synonym: "Isoniazid" RELATED [KEGG_COMPOUND] synonym: "isoniazid" RELATED [UniProt] synonym: "isonicotinic acid hydrazide" RELATED [NIST_Chemistry_WebBook] synonym: "isonicotinic hydrazide" RELATED [ChEBI] synonym: "isonicotinohydrazide" RELATED [NIST_Chemistry_WebBook] synonym: "isonicotinoylhydrazide" RELATED [IUPAC] synonym: "Isonicotinsaeurehydrazid" RELATED [ChEBI] synonym: "pyridine-4-carboxylic acid hydrazide" RELATED [ChEBI] xref: DrugBank:DB00951 xref: KEGG:C07054 xref: KEGG:D00346 xref: LINCS:LSM-6682 xref: MetaCyc:ISONIAZIDE xref: Wikipedia:Isoniazid is_a: CHEBI:35363 ! carbohydrazide relationship: has_functional_parent CHEBI:6032 ! isonicotinic acid relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent relationship: RO:0000087 CHEBI:88188 ! has role drug allergen [Term] id: CHEBI:6032 name: isonicotinic acid namespace: chebi_ontology def: "A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring." [] subset: 3_STAR synonym: "4-carboxypyridine" RELATED [NIST_Chemistry_WebBook] synonym: "4-pyridinecarboxylic acid" RELATED [NIST_Chemistry_WebBook] synonym: "gamma-picolinic acid" RELATED [NIST_Chemistry_WebBook] synonym: "gamma-pyridinecarboxylic acid" RELATED [ChemIDplus] synonym: "Isonicotinic acid" EXACT [KEGG_COMPOUND] synonym: "p-pyridinecarboxylic acid" RELATED [ChemIDplus] xref: HMDB:HMDB0060665 xref: KEGG:C07446 xref: Wikipedia:Isonicotinic_Acid is_a: CHEBI:26420 ! pyridinemonocarboxylic acid relationship: is_conjugate_acid_of CHEBI:38186 ! isonicotinate relationship: RO:0000087 CHEBI:77746 ! has role human metabolite relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite [Term] id: CHEBI:60334 name: peptide anion namespace: chebi_ontology def: "An anion formed by deprotonation of at least one peptide carboxy group." [] subset: 3_STAR synonym: "peptide anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion [Term] id: CHEBI:60466 name: peptide zwitterion namespace: chebi_ontology def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." [] subset: 3_STAR synonym: "a peptide" RELATED [UniProt] synonym: "peptide zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:16670 ! peptide [Term] id: CHEBI:60600 name: amide fungicide namespace: chebi_ontology def: "Compounds that contain an amide group as a key feature of their structure and which have been used as fungicides." [] subset: 3_STAR synonym: "amide fungicides" RELATED [ChEBI] is_a: CHEBI:87012 ! amide antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:60643 name: NMDA receptor antagonist namespace: chebi_ontology alt_id: CHEBI:60797 def: "Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs." [] subset: 3_STAR synonym: "N-methyl-D-aspartate receptor antagonist" RELATED [ChEBI] synonym: "N-methyl-D-aspartate receptor antagonists" RELATED [ChEBI] synonym: "NMDA receptor antagonists" RELATED [ChEBI] synonym: "NMDAR antagonist" RELATED [ChEBI] synonym: "NMDAR antagonists" RELATED [ChEBI] is_a: CHEBI:60798 ! excitatory amino acid antagonist [Term] id: CHEBI:60690 name: nitrogen-containing fatty acid namespace: chebi_ontology def: "Any fatty acid containing nitrogen as either a substituent or a replacement for a methylene carbon." [] subset: 3_STAR synonym: "N-containing fatty acid" RELATED [ChEBI] synonym: "N-containing fatty acids" RELATED [ChEBI] synonym: "nitrogen-containing fatty acids" RELATED [ChEBI] is_a: CHEBI:35366 ! fatty acid relationship: is_conjugate_acid_of CHEBI:61008 ! nitrogen-containing fatty acid anion [Term] id: CHEBI:6076 name: itraconazole namespace: chebi_ontology def: "An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis." [] subset: 3_STAR synonym: "Itraconazole" EXACT [KEGG_DRUG] synonym: "itraconazole" EXACT [UniProt] synonym: "Itrizole (TN)" RELATED [KEGG_DRUG] synonym: "Oriconazole" RELATED [ChemIDplus] synonym: "Sporanox (TN)" RELATED [KEGG_DRUG] xref: DrugBank:DB01167 xref: KEGG:D00350 xref: Patent:EP6711 xref: Patent:US4267179 xref: VSDB:1853 xref: Wikipedia:Itraconazole is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: RO:0000087 CHEBI:140921 ! has role Hedgehog signaling pathway inhibitor relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor [Term] id: CHEBI:60783 name: nucleoside analogue namespace: chebi_ontology def: "An analogue of a nucleoside, being an N-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells." [] subset: 3_STAR synonym: "nucleoside analogues" RELATED [ChEBI] is_a: CHEBI:21731 ! N-glycosyl compound [Term] id: CHEBI:60798 name: excitatory amino acid antagonist namespace: chebi_ontology def: "Any substance which inhibits the action of receptors for excitatory amino acids." [] subset: 3_STAR synonym: "EAA receptor antagonist" RELATED [ChEBI] synonym: "EAA receptor antagonists" RELATED [ChEBI] synonym: "excitatory amino acid antagonists" RELATED [ChEBI] synonym: "excitatory amino acid receptor antagonist" RELATED [ChEBI] synonym: "excitatory amino acid receptor antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:60809 name: adjuvant namespace: chebi_ontology def: "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." [] subset: 3_STAR synonym: "adjuvants" RELATED [ChEBI] is_a: CHEBI:52217 ! pharmaceutical [Term] id: CHEBI:60832 name: tubulin modulator namespace: chebi_ontology def: "Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules." [] subset: 3_STAR synonym: "tubulin modulators" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:60895 name: D-alpha-amino acid anion namespace: chebi_ontology def: "Any alpha-amino acid anion in which the parent amino acid has D-configuration." [] subset: 3_STAR synonym: "D-alpha-amino acid anions" RELATED [ChEBI] synonym: "D-alpha-amino carboxylate" RELATED [ChEBI] is_a: CHEBI:33558 ! alpha-amino-acid anion relationship: is_conjugate_base_of CHEBI:16733 ! D-alpha-amino acid [Term] id: CHEBI:60911 name: racemate namespace: chebi_ontology def: "A racemate is an equimolar mixture of a pair of enantiomers." [] subset: 3_STAR synonym: "melange racemique" RELATED [ChEBI] synonym: "racemates" RELATED [ChEBI] synonym: "racemic mixture" RELATED [ChEBI] is_a: CHEBI:60004 ! mixture [Term] id: CHEBI:60915 name: diastereoisomeric mixture namespace: chebi_ontology def: "A mixture composed of two or more diastereoisomers (stereoisomers not related as mirror images)." [] subset: 3_STAR synonym: "diastereomeric mixture" RELATED [ChEBI] is_a: CHEBI:60004 ! mixture [Term] id: CHEBI:60926 name: amino monosaccharide namespace: chebi_ontology def: "Any amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." [] subset: 3_STAR synonym: "amino monosaccharides" RELATED [ChEBI] is_a: CHEBI:28963 ! amino sugar [Term] id: CHEBI:60979 name: alpha-glucoside namespace: chebi_ontology def: "A glucoside in which the anomeric carbon of the glycosidic bond is in an alpha configuration" [] subset: 3_STAR synonym: "alpha-glucosides" RELATED [ChEBI] is_a: CHEBI:24278 ! glucoside [Term] id: CHEBI:61007 name: amino fatty acid anion namespace: chebi_ontology def: "A nitrogen-containing fatty acid anion arising from deprotonation of the carboxy group of any amino fatty acid." [] subset: 3_STAR synonym: "amino FA anion" RELATED [ChEBI] synonym: "amino FA anions" RELATED [ChEBI] synonym: "amino fatty acid anions" RELATED [ChEBI] synonym: "NH2-FA anion" RELATED [ChEBI] synonym: "NH2-FA anions" RELATED [ChEBI] synonym: "NH2-fatty acid anion" RELATED [ChEBI] synonym: "NH2-fatty acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion is_a: CHEBI:61008 ! nitrogen-containing fatty acid anion relationship: is_conjugate_base_of CHEBI:59650 ! amino fatty acid [Term] id: CHEBI:61008 name: nitrogen-containing fatty acid anion namespace: chebi_ontology def: "A fatty acid anion arising from deprotonation of the carboxylic acid group of any nitrogen-containing fatty acid." [] subset: 3_STAR synonym: "N-containing FA anion" RELATED [ChEBI] synonym: "N-containing FA anions" RELATED [ChEBI] synonym: "N-containing fatty acid anions" RELATED [ChEBI] synonym: "nitrogen-containing FA anion" RELATED [ChEBI] synonym: "nitrogen-containing FA anions" RELATED [ChEBI] synonym: "nitrogen-containing fatty acid anion" EXACT [ChEBI] synonym: "nitrogen-containing fatty acid anions" RELATED [ChEBI] is_a: CHEBI:28868 ! fatty acid anion relationship: is_conjugate_base_of CHEBI:60690 ! nitrogen-containing fatty acid [Term] id: CHEBI:61115 name: EC 3.5.1.98 (histone deacetylase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98)." [] subset: 3_STAR synonym: "EC 3.5.1.98 (histone deacetylase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.98 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.98 inhibitors" RELATED [ChEBI] synonym: "HDAC inhibitor" RELATED [ChEBI] synonym: "HDAC inhibitors" RELATED [ChEBI] synonym: "HDACi" RELATED [ChEBI] synonym: "HDACis" RELATED [ChEBI] synonym: "HDI" RELATED [ChEBI] synonym: "HDIs" RELATED [ChEBI] synonym: "histone amidohydrolase inhibitor" RELATED [ChEBI] synonym: "histone amidohydrolase inhibitors" RELATED [ChEBI] synonym: "histone deacetylase (EC 3.5.1.98) inhibitor" RELATED [ChEBI] synonym: "histone deacetylase (EC 3.5.1.98) inhibitors" RELATED [ChEBI] synonym: "histone deacetylase inhibitor" RELATED [ChEBI] synonym: "histone deacetylase inhibitors" RELATED [ChEBI] xref: Wikipedia:Histone_deacetylase_inhibitor is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:61120 name: nucleobase-containing molecular entity namespace: chebi_ontology def: "Any compound that has a nucleobase as a part." [] subset: 3_STAR synonym: "nucleobase-containing compound" RELATED [SUBMITTER] synonym: "nucleobase-containing compounds" RELATED [ChEBI] synonym: "nucleobase-containing molecular entities" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:51143 ! nitrogen molecular entity relationship: has_functional_parent CHEBI:18282 ! nucleobase [Term] id: CHEBI:61293 name: adenyl nucleotide namespace: chebi_ontology def: "A nucleotide having adenine as the base." [] subset: 3_STAR synonym: "adenine nucleotide" RELATED [SUBMITTER] is_a: CHEBI:26395 ! purine nucleotide [Term] id: CHEBI:61296 name: adenyl ribonucleotide namespace: chebi_ontology def: "A purine riboncleotide where adenine is the purine." [] subset: 3_STAR synonym: "adenine ribonucleotide" RELATED [SUBMITTER] is_a: CHEBI:26400 ! purine ribonucleotide is_a: CHEBI:61293 ! adenyl nucleotide [Term] id: CHEBI:61689 name: amino cyclitol namespace: chebi_ontology def: "Any cyclitol having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." [] subset: 3_STAR synonym: "amino cyclitols" RELATED [ChEBI] synonym: "aminocyclitol" RELATED [ChEBI] synonym: "aminocyclitols" RELATED [ChEBI] is_a: CHEBI:23451 ! cyclitol [Term] id: CHEBI:61739 name: aureobasidin A namespace: chebi_ontology def: "A cyclodepsipeptide antibiotic, which is isolated from the filamentous fungus Aureobasidium pullulans R106 and is toxic to yeast at low concentrations (0.1-0.5 ug/ml)." [] subset: 3_STAR synonym: "(3S,6S,9S,12S,15S,18S,21S,24R,27S)-12,24-bis[(2R)-butan-2-yl]-15-(2-hydroxypropan-2-yl)-4,10,16,22-tetramethyl-18-(2-methylpropyl)-3,6-bis(phenylmethyl)-9,21-di(propan-2-yl)-13-oxa-1,4,7,10,16,19,22,25-octazabicyclo[25.3.0]triacontane-2,5,8,11,14,17,20,23,26-nonone" RELATED [SUBMITTER] synonym: "Antibiotic R106I" RELATED [ChEBI] synonym: "N-((2R,3R)-2-hydroxy-3-methylvaleryl)-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl-L- alloisoleucyl-N-methyl-L-valyl-L-leucyl-3-hydroxy-N-methyl- L-valine alpha1-lactone" RELATED [ChemIDplus] is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:35213 ! cyclodepsipeptide relationship: RO:0000087 CHEBI:61774 ! has role inositol phosphorylceramide synthase inhibitor [Term] id: CHEBI:61774 name: inositol phosphorylceramide synthase inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of inositol phosphorylceramide synthase." [] subset: 3_STAR is_a: CHEBI:76881 ! EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor [Term] id: CHEBI:61951 name: microtubule-destabilising agent namespace: chebi_ontology def: "Any substance that interacts with tubulin to inhibit polymerisation of microtubules." [] subset: 3_STAR synonym: "microtubule destabilising agent" RELATED [ChEBI] synonym: "microtubule destabilising agents" RELATED [ChEBI] synonym: "microtubule destabilising role" RELATED [ChEBI] synonym: "microtubule destabilizing role" RELATED [SUBMITTER] synonym: "microtubule-destabilising agents" RELATED [ChEBI] synonym: "microtubule-destabilizing agent" RELATED [ChEBI] synonym: "microtubule-destabilizing agents" RELATED [ChEBI] is_a: CHEBI:60832 ! tubulin modulator is_a: CHEBI:64911 ! antimitotic [Term] id: CHEBI:62031 name: polar amino acid zwitterion namespace: chebi_ontology def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." [] subset: 2_STAR synonym: "a polar amino acid" RELATED [UniProt] is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:26167 ! polar amino acid [Term] id: CHEBI:62070 name: nalidixic acid anion namespace: chebi_ontology def: "A monocarboxylic acid anion that is the conjugate base of nalidixic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "nalidixate" RELATED [ChEBI] synonym: "nalidixate anion" RELATED [ChEBI] synonym: "nalidixate(1-)" RELATED [ChEBI] synonym: "nalidixylate" RELATED [SUBMITTER] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:100147 ! nalidixic acid [Term] id: CHEBI:62220 name: pyocyanine(1+) namespace: chebi_ontology def: "An organic cation resulting from the protonation of pyocyanin." [] subset: 3_STAR synonym: "5-methylphenazin-1(5H)-one" RELATED [MetaCyc] synonym: "pyocyanin" RELATED [UniProt] synonym: "pyocyanin(1+)" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:39201 ! phenazines relationship: is_conjugate_acid_of CHEBI:8653 ! pyocyanine [Term] id: CHEBI:62247 name: (1R,2S)-epoxypropylphosphonate(1-) namespace: chebi_ontology def: "An organophosphonate oxoanion obtained by deprotonation of one of the two phosphonate OH groups of (1R,2S)-epoxypropylphosphonic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "(1R,2S)-epoxypropylphosphonate" RELATED [UniProt] synonym: "fosfomycin" RELATED [SUBMITTER] synonym: "fosfomycin(1-)" RELATED [ChEBI] xref: MetaCyc:CPD0-1113 is_a: CHEBI:59635 ! organophosphonate oxoanion relationship: is_conjugate_acid_of CHEBI:62419 ! (1R,2S)-epoxypropylphosphonate(2-) relationship: is_conjugate_base_of CHEBI:28915 ! fosfomycin relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:623918 name: nikkomycin Z namespace: chebi_ontology alt_id: CHEBI:109145 alt_id: CHEBI:621961 def: "A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase." [] subset: 3_STAR synonym: "(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-beta-D-allo-furanuronic acid" RELATED [ChEBI] synonym: "(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]acetic acid" RELATED [ChEBI] synonym: "Neopolyoxin C" RELATED [ChemIDplus] synonym: "Nikkomycin" RELATED [ChemIDplus] is_a: CHEBI:59668 ! nikkomycin relationship: has_functional_parent CHEBI:16704 ! uridine relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:62419 name: (1R,2S)-epoxypropylphosphonate(2-) namespace: chebi_ontology def: "An organophosphonate oxoanion obtained by deprotonation of the two phosphonate OH groups of (1R,2S)-epoxypropylphosphonic acid." [] subset: 3_STAR synonym: "(1R,2S)-epoxypropylphosphonate" RELATED [ChEBI] synonym: "(1R,2S)-epoxypropylphosphonate dianion" RELATED [ChEBI] synonym: "fosfomycin" RELATED [ChEBI] synonym: "fosfomycin dianion" RELATED [ChEBI] synonym: "fosfomycin(2-)" RELATED [ChEBI] is_a: CHEBI:71285 ! organophosphonate(2-) relationship: is_conjugate_base_of CHEBI:62247 ! (1R,2S)-epoxypropylphosphonate(1-) [Term] id: CHEBI:62488 name: signalling molecule namespace: chebi_ontology def: "A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell." [] subset: 3_STAR synonym: "signal molecule" RELATED [ChEBI] synonym: "signal molecules" RELATED [ChEBI] synonym: "signaling molecule" RELATED [ChEBI] synonym: "signaling molecules" RELATED [ChEBI] synonym: "signalling molecules" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger [Term] id: CHEBI:62643 name: anionic phospholipid namespace: chebi_ontology def: "Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1-), phosphatidate(2-), phosphatidylglycerol(1-)." [] subset: 3_STAR synonym: "anionic phospholipids" RELATED [ChEBI] synonym: "phospholipid anion" RELATED [ChEBI] synonym: "phospholipid anions" RELATED [ChEBI] is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:16247 ! phospholipid [Term] id: CHEBI:62733 name: aromatic amide namespace: chebi_ontology def: "An amide in which the amide linkage is bonded directly to an aromatic system." [] subset: 3_STAR synonym: "aromatic amides" RELATED [ChEBI] is_a: CHEBI:32988 ! amide is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:62868 name: hepatoprotective agent namespace: chebi_ontology def: "Any compound that is able to prevent damage to the liver." [] subset: 3_STAR synonym: "antihepatotoxic agent" RELATED [ChEBI] synonym: "hepatoprotective agents" RELATED [ChEBI] synonym: "hepatoprotector" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:62872 name: EC 1.2.3.1 (aldehyde oxidase) inhibitor namespace: chebi_ontology def: "An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1)." [] subset: 3_STAR synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitor" RELATED [ChEBI] synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitors" RELATED [ChEBI] synonym: "aldehyde oxidase inhibitor" RELATED [ChEBI] synonym: "aldehyde oxidase inhibitors" RELATED [ChEBI] synonym: "aldehyde:oxygen oxidoreductase inhibitor" RELATED [ChEBI] synonym: "aldehyde:oxygen oxidoreductase inhibitors" RELATED [ChEBI] synonym: "EC 1.2.3.1 (aldehyde oxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.3.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.2.3.1 inhibitors" RELATED [ChEBI] synonym: "quinoline oxidase inhibitor" RELATED [ChEBI] synonym: "quinoline oxidase inhibitors" RELATED [ChEBI] synonym: "retinal oxidase inhibitor" RELATED [ChEBI] synonym: "retinal oxidase inhibitors" RELATED [ChEBI] synonym: "retinoic acid synthase inhibitor" RELATED [ChEBI] synonym: "retinoic acid synthase inhibitors" RELATED [ChEBI] xref: Wikipedia:Aldehyde_oxidase is_a: CHEBI:76853 ! EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor [Term] id: CHEBI:62913 name: EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD(+) ADP-ribosyltransferase (EC 2.4.2.30)." [] subset: 3_STAR synonym: "ADP-ribosyltransferase (polymerising) inhibitor" RELATED [ChEBI] synonym: "ADP-ribosyltransferase (polymerising) inhibitors" RELATED [ChEBI] synonym: "ADP-ribosyltransferase (polymerizing) inhibitor" RELATED [ChEBI] synonym: "ADP-ribosyltransferase (polymerizing) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.2.30 inhibitor" RELATED [ChEBI] synonym: "EC 2.4.2.30 inhibitors" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitor" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitors" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase inhibitor" RELATED [ChEBI] synonym: "NAD(+) ADP-ribosyltransferase inhibitors" RELATED [ChEBI] synonym: "NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor" RELATED [ChEBI] synonym: "NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors" RELATED [ChEBI] synonym: "NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor" RELATED [ChEBI] synonym: "NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors" RELATED [ChEBI] synonym: "PARP" RELATED [ChEBI] synonym: "PARPs" RELATED [ChEBI] synonym: "poly(adenosine diphosphate ribose) polymerase inhibitor" RELATED [ChEBI] synonym: "poly(adenosine diphosphate ribose) polymerase inhibitors" RELATED [ChEBI] synonym: "poly(ADP-ribose) polymerase inhibitor" RELATED [ChEBI] synonym: "poly(ADP-ribose) polymerase inhibitors" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthase inhibitor" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthase inhibitors" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthetase inhibitor" RELATED [ChEBI] synonym: "poly(ADP-ribose) synthetase inhibitors" RELATED [ChEBI] xref: Wikipedia:PARP_inhibitor is_a: CHEBI:76790 ! EC 2.4.2.* (pentosyltransferase) inhibitor [Term] id: CHEBI:63046 name: emulsifier namespace: chebi_ontology def: "The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability." [] subset: 3_STAR synonym: "emulgent" RELATED [ChEBI] synonym: "emulgents" RELATED [ChEBI] synonym: "emulsifiers" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63161 name: glycosyl compound namespace: chebi_ontology def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." [] subset: 3_STAR synonym: "glycosyl compounds" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:63247 name: reducing agent namespace: chebi_ontology def: "The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species." [] subset: 3_STAR synonym: "reducer" RELATED [ChEBI] synonym: "reducers" RELATED [ChEBI] synonym: "reducing agents" RELATED [ChEBI] synonym: "reductant" RELATED [ChEBI] synonym: "reductants" RELATED [ChEBI] xref: Wikipedia:Reducing_agent is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63248 name: oxidising agent namespace: chebi_ontology def: "A substance that removes electrons from another reactant in a redox reaction." [] subset: 3_STAR synonym: "oxidant" RELATED [ChEBI] synonym: "oxidants" RELATED [ChEBI] synonym: "oxidiser" RELATED [ChEBI] synonym: "oxidisers" RELATED [ChEBI] synonym: "oxidising agents" RELATED [ChEBI] synonym: "oxidizer" RELATED [ChEBI] synonym: "oxidizers" RELATED [ChEBI] synonym: "oxidizing agent" RELATED [ChEBI] synonym: "oxidizing agents" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63299 name: carbohydrate derivative namespace: chebi_ontology def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." [] subset: 3_STAR synonym: "carbohydrate derivatives" RELATED [ChEBI] synonym: "derivatised carbohydrate" RELATED [ChEBI] synonym: "derivatised carbohydrates" RELATED [ChEBI] synonym: "derivatized carbohydrate" RELATED [ChEBI] synonym: "derivatized carbohydrates" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives relationship: has_functional_parent CHEBI:16646 ! carbohydrate [Term] id: CHEBI:63353 name: disaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a disaccharide." [] subset: 3_STAR synonym: "disaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:36233 ! disaccharide [Term] id: CHEBI:63367 name: monosaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a monosaccharide." [] subset: 3_STAR synonym: "monosaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:35381 ! monosaccharide [Term] id: CHEBI:63409 name: pentose derivative namespace: chebi_ontology def: "A monosaccharide derivative that is formally obtained from a pentose." [] subset: 3_STAR synonym: "pentose derivatives" RELATED [ChEBI] is_a: CHEBI:63367 ! monosaccharide derivative relationship: has_functional_parent CHEBI:25901 ! pentose [Term] id: CHEBI:63473 name: aromatic amino-acid anion namespace: chebi_ontology def: "An aromatic amino acid whose alpha-carboxylic acid group is ionized (non-protonated)." [] subset: 3_STAR synonym: "aromatic amino-acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33856 ! aromatic amino acid [Term] id: CHEBI:63490 name: explosive namespace: chebi_ontology def: "A substance capable of undergoing rapid and highly exothermic decomposition." [] subset: 3_STAR synonym: "explosive compound" RELATED [ChEBI] synonym: "explosive compounds" RELATED [ChEBI] synonym: "explosive material" RELATED [ChEBI] synonym: "explosives" RELATED [ChEBI] synonym: "explosives chemical" RELATED [ChEBI] synonym: "explosives chemicals" RELATED [ChEBI] xref: Wikipedia:Explosive_material is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:63598 name: levofloxacin namespace: chebi_ontology alt_id: CHEBI:6440 def: "An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase." [] subset: 3_STAR synonym: "(-)-Ofloxacin" RELATED [ChemIDplus] synonym: "(-)-ofloxacin" RELATED [ChEBI] synonym: "(3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid" RELATED [ChEBI] synonym: "(S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid" RELATED [ChEBI] synonym: "(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid" RELATED [ChemIDplus] synonym: "(S)-ofloxacin" RELATED [ChemIDplus] synonym: "DR 3355" RELATED [ChEBI] synonym: "DR-3355" RELATED [ChEBI] synonym: "L-ofloxacin" RELATED [DrugBank] synonym: "Ofloxacin S-(-)-form" RELATED [KEGG_COMPOUND] synonym: "S-(-)-ofloxacin" RELATED [ChEBI] xref: DrugBank:DB01137 xref: HMDB:HMDB0001929 xref: KEGG:C07660 xref: KEGG:D08120 xref: LINCS:LSM-5270 xref: PDBeChem:LFX xref: VSDB:1899 xref: Wikipedia:Levofloxacin is_a: CHEBI:194135 ! 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_acid_of CHEBI:231553 ! levofloxacin(1-) relationship: is_enantiomer_of CHEBI:46577 ! dextrofloxacin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor [Term] id: CHEBI:63607 name: linezolid namespace: chebi_ontology alt_id: CHEBI:6477 def: "An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex." [] subset: 3_STAR synonym: "Linezolid" EXACT [KEGG_COMPOUND] synonym: "N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide" RELATED [ChemIDplus] xref: DrugBank:DB00601 xref: KEGG:C08146 xref: KEGG:D00947 xref: LINCS:LSM-5750 xref: Patent:US5688792 xref: Patent:WO957271 xref: PDBeChem:ZLD xref: Wikipedia:Linezolid is_a: CHEBI:22160 ! acetamides is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38785 ! morpholines is_a: CHEBI:55374 ! oxazolidinone relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor [Term] id: CHEBI:63611 name: moxifloxacin namespace: chebi_ontology alt_id: CHEBI:7007 def: "A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents." [] subset: 3_STAR synonym: "1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid" RELATED [ChemIDplus] synonym: "Moxifloxacin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00218 xref: KEGG:C07663 xref: KEGG:D08237 xref: LINCS:LSM-5746 xref: Patent:EP550903 xref: VSDB:2983 xref: Wikipedia:Moxifloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51454 ! cyclopropanes is_a: CHEBI:63697 ! pyrrolidinopiperidine is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_base_of CHEBI:63699 ! moxifloxacinium(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:63673 name: chemokine receptor 5 antagonist namespace: chebi_ontology def: "An antogonist that blocks chemokine receptor 5 (CCR5)." [] subset: 3_STAR synonym: "C-C chemokine receptor 5 antagonist" RELATED [ChEBI] synonym: "C-C chemokine receptor 5 antagonists" RELATED [ChEBI] synonym: "CCR-5 antagonist" RELATED [ChEBI] synonym: "CCR-5 antagonists" RELATED [ChEBI] synonym: "CCR5 antagonist" RELATED [ChEBI] synonym: "CCR5 antagonists" RELATED [ChEBI] synonym: "chemokine receptor 5 antagonists" RELATED [ChEBI] xref: Wikipedia:CCR5 is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:63697 name: pyrrolidinopiperidine namespace: chebi_ontology def: "Any organic heterobicyclic compound containing ortho-fused pyrrolidine and piperidine rings." [] subset: 3_STAR is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:63699 name: moxifloxacinium(1+) namespace: chebi_ontology def: "An organic cation obtained by protonation of moxifloxacin." [] subset: 3_STAR synonym: "moxifloxacin cation" RELATED [ChEBI] synonym: "moxifloxacin(1+)" RELATED [ChEBI] synonym: "moxifloxacinium" RELATED [ChEBI] synonym: "moxifloxacinium cation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:63611 ! moxifloxacin [Term] id: CHEBI:63726 name: neuroprotective agent namespace: chebi_ontology def: "Any compound that can be used for the treatment of neurodegenerative disorders." [] subset: 3_STAR synonym: "neuroprotectant" RELATED [ChEBI] synonym: "neuroprotectants" RELATED [ChEBI] synonym: "neuroprotective agents" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent [Term] id: CHEBI:63944 name: macrocyclic lactone namespace: chebi_ontology alt_id: CHEBI:50333 def: "Any lactone in which the cyclic carboxylic ester group forms a part of a cyclic macromolecule." [] subset: 3_STAR synonym: "macrocyclic lactones" RELATED [ChEBI] is_a: CHEBI:25000 ! lactone is_a: CHEBI:51026 ! macrocycle [Term] id: CHEBI:63951 name: estrogen receptor agonist namespace: chebi_ontology def: "An agonist at the estrogen receptor." [] subset: 3_STAR synonym: "estrogen receptor agonists" RELATED [ChEBI] is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:64047 name: food additive namespace: chebi_ontology def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." [] subset: 3_STAR synonym: "food additives" RELATED [ChEBI] xref: Wikipedia:Food_additive is_a: CHEBI:33232 ! application is_a: CHEBI:78295 ! food component [Term] id: CHEBI:64049 name: food acidity regulator namespace: chebi_ontology def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." [] subset: 3_STAR synonym: "acidity regulator" RELATED [ChEBI] synonym: "acidity regulators" RELATED [ChEBI] synonym: "food acidity regulators" RELATED [ChEBI] synonym: "pH control agent" RELATED [ChEBI] synonym: "pH control agents" RELATED [ChEBI] xref: Wikipedia:Acidity_regulator is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:64130 name: pyrazinoindole namespace: chebi_ontology def: "An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system." [] subset: 3_STAR synonym: "pyrazinoindoles" RELATED [ChEBI] is_a: CHEBI:38101 ! organonitrogen heterocyclic compound [Term] id: CHEBI:64133 name: EC 2.5.1.58 (protein farnesyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein farnesyltransferase (EC 2.5.1.58), one of the three enzymes in the prenyltransferase group." [] subset: 3_STAR synonym: "EC 2.5.1.58 (protein farnesyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.58 inhibitor" RELATED [ChEBI] synonym: "EC 2.5.1.58 inhibitors" RELATED [ChEBI] synonym: "farnesyl transferase inhibitor" RELATED [ChEBI] synonym: "farnesyl transferase inhibitors" RELATED [ChEBI] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitor" RELATED [ChEBI] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors" RELATED [ChEBI] synonym: "farnesyltransferase inhibitor" RELATED [ChEBI] synonym: "farnesyltransferase inhibitors" RELATED [ChEBI] synonym: "FTase inhibitor" RELATED [ChEBI] synonym: "FTase inhibitors" RELATED [ChEBI] synonym: "protein farnesyltransferase (EC 2.5.1.58) inhibitor" RELATED [ChEBI] synonym: "protein farnesyltransferase (EC 2.5.1.58) inhibitors" RELATED [ChEBI] synonym: "protein farnesyltransferase inhibitor" RELATED [ChEBI] synonym: "protein farnesyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Farnesyltransferase is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor [Term] id: CHEBI:64228 name: tunicamycin A0 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by an 11-methyldodec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "tunicamycin I" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64237 name: EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor namespace: chebi_ontology def: "An EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor that interferes with the action of any UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15), preventing formation of N-acetylglucosamine lipid intermediates and glycosylation of newly synthesised glycoproteins." [] subset: 3_STAR synonym: "chitobiosylpyrophosphoryldolichol synthase inhibitor" RELATED [ChEBI] synonym: "chitobiosylpyrophosphoryldolichol synthase inhibitors" RELATED [ChEBI] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.8.15 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.8.15 inhibitors" RELATED [ChEBI] synonym: "GlcNAc-1-P transferase inhibitor" RELATED [ChEBI] synonym: "GlcNAc-1-P transferase inhibitors" RELATED [ChEBI] synonym: "N-acetylglucosamine phosphotransferase inhibitor" RELATED [ChEBI] synonym: "N-acetylglucosamine transferase inhibitors" RELATED [ChEBI] synonym: "N-acetylglucosamine-1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "N-acetylglucosamine-1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitors" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors" RELATED [ChEBI] synonym: "uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76816 ! EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor [Term] id: CHEBI:64245 name: tunicamycin A1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 12-methyltridec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "tunicamycin A1" EXACT [UniProt] synonym: "tunicamycin C" RELATED [ChEBI] synonym: "tunicamycin II" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64246 name: tunicamycin A2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a tetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "tunicamycin III" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64248 name: tunicamycin B1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a pentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "tunicamycin IV" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64250 name: tunicamycin B2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 13-methyltetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "tunicamycin A" RELATED [ChEBI] synonym: "tunicamycin V" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64255 name: tunicamycin B3 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by an 13-methyltetradecanoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "tunicamycin VI" RELATED [ChEBI] is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64256 name: tunicamycin C1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 14-methylpentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR synonym: "corynetoxin U-16I" RELATED [ChemIDplus] synonym: "tunicamycin B" RELATED [ChEBI] synonym: "tunicamycin VII" RELATED [ChEBI] xref: Chemspider:27471426 xref: MetaCyc:CPD-19373 is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:64257 name: tunicamycin C2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a hexadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64268 name: erythromycin A(1+) namespace: chebi_ontology def: "An erythromycin cation that is the conjugate acid of erythromycin A, arising from protonation of the tertiary amino group on the 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residue; major species at pH 7.3." [] subset: 3_STAR synonym: "erythromycin A" RELATED [UniProt] synonym: "erythromycin A cation" RELATED [ChEBI] is_a: CHEBI:64290 ! erythromycin cation relationship: is_conjugate_acid_of CHEBI:42355 ! erythromycin A relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:64271 name: tunicamycin D1 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a heptadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64272 name: tunicamycin D2 namespace: chebi_ontology def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 15-methylhexadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." [] subset: 3_STAR is_a: CHEBI:33838 ! nucleoside relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:64290 name: erythromycin cation namespace: chebi_ontology def: "An organic cation obtained by protonation of any erythromycin." [] subset: 3_STAR synonym: "erythromycin cation" EXACT [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_base_of CHEBI:48923 ! erythromycin [Term] id: CHEBI:64355 name: posaconazole namespace: chebi_ontology def: "An N-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug." [] subset: 3_STAR synonym: "posaconazole" EXACT [UniProt] synonym: "Sch 56592" RELATED [ChemIDplus] synonym: "SCH56592" RELATED [ChEBI] synonym: "Schering 56592" RELATED [ChEBI] xref: DrugBank:DB01263 xref: KEGG:D02555 xref: Patent:US5661151 xref: Patent:WO9517407 xref: Wikipedia:Posaconazole is_a: CHEBI:26912 ! oxolanes is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:87071 ! conazole antifungal drug is_a: CHEBI:87101 ! triazole antifungal drug relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug [Term] id: CHEBI:64383 name: pentamidinium(2+) namespace: chebi_ontology def: "A carboxamidinium ion obtained by protonation of both amindino groups of pentamidine." [] subset: 3_STAR synonym: "pentamidine dication" RELATED [ChEBI] synonym: "pentamidine(2+)" RELATED [ChEBI] synonym: "pentamidinium cation" RELATED [ChEBI] synonym: "pentamidinium dication" RELATED [ChEBI] is_a: CHEBI:77718 ! carboxamidinium ion relationship: is_conjugate_acid_of CHEBI:45081 ! pentamidine [Term] id: CHEBI:64459 name: biaryl namespace: chebi_ontology def: "An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond." [] subset: 3_STAR synonym: "biaryls" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound [Term] id: CHEBI:64571 name: NMDA receptor agonist namespace: chebi_ontology def: "An excitatory amino acid agonist which binds to NMDA receptors and triggers a response." [] subset: 3_STAR synonym: "N-methyl-D-aspartate receptor agonist" RELATED [ChEBI] synonym: "N-methyl-D-aspartate receptor agonists" RELATED [ChEBI] synonym: "NMDA receptor agonists" RELATED [ChEBI] synonym: "NMDAR agonist" RELATED [ChEBI] synonym: "NMDAR agonists" RELATED [ChEBI] is_a: CHEBI:50103 ! excitatory amino acid agonist [Term] id: CHEBI:64577 name: flour treatment agent namespace: chebi_ontology def: "A food additive which is added to flour or dough to improve baking quality and/or colour." [] subset: 3_STAR synonym: "dough improver" RELATED [ChEBI] synonym: "dough improvers" RELATED [ChEBI] synonym: "flour treatment agent" EXACT [ChEBI] synonym: "improving agent" RELATED [ChEBI] synonym: "improving agents" RELATED [ChEBI] xref: Wikipedia:Flour_treatment_agent is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:64641 name: divalent inorganic cation namespace: chebi_ontology def: "An inorganic cation with a valency of two." [] subset: 3_STAR is_a: CHEBI:36915 ! inorganic cation [Term] id: CHEBI:64708 name: one-carbon compound namespace: chebi_ontology def: "An organic molecular entity containing a single carbon atom (C1)." [] subset: 3_STAR synonym: "one-carbon compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:64709 name: organic acid namespace: chebi_ontology def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." [] subset: 3_STAR synonym: "organic acids" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:6472 name: lincomycin namespace: chebi_ontology def: "A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis." [] subset: 3_STAR synonym: "Cillimycin" RELATED [ChemIDplus] synonym: "Lincomycin" EXACT [KEGG_COMPOUND] synonym: "Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside" RELATED [NIST_Chemistry_WebBook] xref: DrugBank:DB01627 xref: HMDB:HMDB0015564 xref: KEGG:C06812 xref: KEGG:C14002 xref: KEGG:D00223 xref: KEGG:D02346 xref: LINCS:LSM-5602 xref: Wikipedia:Lincomycin is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:35275 ! S-glycosyl compound is_a: CHEBI:46770 ! pyrrolidinecarboxamide is_a: CHEBI:84186 ! L-proline derivative relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:64766 name: cationic group namespace: chebi_ontology def: "A group that carries an overall positive charge." [] subset: 3_STAR synonym: "cationic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:64767 name: anionic group namespace: chebi_ontology def: "A group that carries an overall negative charge." [] subset: 3_STAR synonym: "anionic groups" RELATED [ChEBI] is_a: CHEBI:24433 ! group [Term] id: CHEBI:64769 name: organic cationic group namespace: chebi_ontology def: "A cationic group that contains carbon." [] subset: 3_STAR synonym: "organic cationic groups" RELATED [ChEBI] is_a: CHEBI:64766 ! cationic group relationship: is_conjugate_acid_of CHEBI:33247 ! organic group [Term] id: CHEBI:64775 name: organic anionic group namespace: chebi_ontology def: "An anionic group that contains carbon." [] subset: 3_STAR synonym: "organic anionic groups" RELATED [ChEBI] is_a: CHEBI:64767 ! anionic group relationship: is_conjugate_base_of CHEBI:33247 ! organic group [Term] id: CHEBI:64898 name: anionic amino-acid residue namespace: chebi_ontology def: "An amino-acid residue carrying an overall negative charge." [] subset: 3_STAR synonym: "amino acid anion residue" RELATED [ChEBI] synonym: "amino acid anion residues" RELATED [ChEBI] synonym: "amino-acid anion residue" RELATED [ChEBI] synonym: "amino-acid anion residues" RELATED [ChEBI] synonym: "anionic amino acid residue" RELATED [ChEBI] synonym: "anionic amino acid residues" RELATED [ChEBI] is_a: CHEBI:64775 ! organic anionic group relationship: is_conjugate_base_of CHEBI:33708 ! amino-acid residue [Term] id: CHEBI:64909 name: poison namespace: chebi_ontology def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." [] subset: 3_STAR synonym: "poisonous agent" RELATED [ChEBI] synonym: "poisonous agents" RELATED [ChEBI] synonym: "poisonous substance" RELATED [ChEBI] synonym: "poisonous substances" RELATED [ChEBI] synonym: "poisons" RELATED [ChEBI] synonym: "toxic agent" RELATED [ChEBI] synonym: "toxic agents" RELATED [ChEBI] synonym: "toxic substance" RELATED [ChEBI] synonym: "toxic substances" RELATED [ChEBI] xref: Wikipedia:Poison is_a: CHEBI:24432 ! biological role [Term] id: CHEBI:64911 name: antimitotic namespace: chebi_ontology def: "Any compound that inhibits cell division (mitosis)." [] subset: 3_STAR synonym: "antimitotics" RELATED [ChEBI] synonym: "mitosis inhibitor" RELATED [ChEBI] synonym: "mitosis inhibitors" RELATED [ChEBI] synonym: "mitotic inhibitor" RELATED [ChEBI] synonym: "mitotic inhibitors" RELATED [ChEBI] xref: Wikipedia:Mitotic_inhibitor is_a: CHEBI:52210 ! pharmacological role [Term] id: CHEBI:64912 name: antimycobacterial drug namespace: chebi_ontology def: "A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy." [] subset: 3_STAR synonym: "antimycobacterial agent" RELATED [ChEBI] synonym: "antimycobacterial agents" RELATED [ChEBI] synonym: "antimycobacterial drugs" RELATED [ChEBI] synonym: "antimycobacterials" RELATED [ChEBI] synonym: "antimycobacterium" RELATED [ChEBI] is_a: CHEBI:36047 ! antibacterial drug [Term] id: CHEBI:64915 name: antiplasmodial drug namespace: chebi_ontology def: "An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria." [] subset: 3_STAR synonym: "antiplasmodial agent" RELATED [ChEBI] synonym: "antiplasmodial agents" RELATED [ChEBI] synonym: "antiplasmodial drugs" RELATED [ChEBI] synonym: "antiplasmodium agent" RELATED [ChEBI] synonym: "antiplasmodium agents" RELATED [ChEBI] synonym: "antiplasmodium drug" RELATED [ChEBI] synonym: "antiplasmodium drugs" RELATED [ChEBI] is_a: CHEBI:35820 ! antiprotozoal drug [Term] id: CHEBI:64933 name: melanin synthesis inhibitor namespace: chebi_ontology def: "A depigmentation agent which inhibits the synthesis of melanin." [] subset: 3_STAR synonym: "melanin biosynthesis inhibitor" RELATED [ChEBI] synonym: "melanin biosynthesis inhibitors" RELATED [ChEBI] synonym: "melanin synthesis inhibitors" RELATED [ChEBI] synonym: "melanogenesis inhibitor" RELATED [ChEBI] synonym: "melanogenesis inhibitors" RELATED [ChEBI] is_a: CHEBI:59864 ! depigmentation drug [Term] id: CHEBI:64946 name: anti-HIV agent namespace: chebi_ontology def: "An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus." [] subset: 3_STAR synonym: "anti-AIDS agent" RELATED [ChEBI] synonym: "anti-AIDS agents" RELATED [ChEBI] synonym: "anti-HIV agents" RELATED [ChEBI] is_a: CHEBI:22587 ! antiviral agent [Term] id: CHEBI:64996 name: EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor namespace: chebi_ontology def: "A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33)." [] subset: 3_STAR synonym: "15-lipoxygenase inhibitor" RELATED [ChEBI] synonym: "15-lipoxygenase inhibitors" RELATED [ChEBI] synonym: "15-LOX inhibitor" RELATED [ChEBI] synonym: "15-LOX inhibitors" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitors" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase inhibitor" RELATED [ChEBI] synonym: "arachidonate 15-lipoxygenase inhibitors" RELATED [ChEBI] synonym: "arachidonate:oxygen 15-oxidoreductase inhibitor" RELATED [ChEBI] synonym: "arachidonate:oxygen 15-oxidoreductase inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.33 inhibitor" RELATED [ChEBI] synonym: "EC 1.13.11.33 inhibitors" RELATED [ChEBI] synonym: "linoleic acid omega(6)-lipoxygenase inhibitor" RELATED [ChEBI] synonym: "linoleic acid omega(6)-lipoxygenase inhibitors" RELATED [ChEBI] synonym: "omega(6) lipoxygenase inhibitor" RELATED [ChEBI] synonym: "omega(6) lipoxygenase inhibitors" RELATED [ChEBI] xref: Wikipedia:ALOX15 is_a: CHEBI:35856 ! lipoxygenase inhibitor [Term] id: CHEBI:65001 name: EC 3.1.1.3 (triacylglycerol lipase) inhibitor namespace: chebi_ontology def: "Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3)." [] subset: 3_STAR synonym: "butyrinase inhibitor" RELATED [ChEBI] synonym: "butyrinase inhibitors" RELATED [ChEBI] synonym: "cacordase inhibitor" RELATED [ChEBI] synonym: "cacordase inhibitors" RELATED [ChEBI] synonym: "capalase L inhibitor" RELATED [ChEBI] synonym: "capalase L inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.3 (triacylglycerol lipase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.3 inhibitor" RELATED [ChEBI] synonym: "EC 3.1.1.3 inhibitors" RELATED [ChEBI] synonym: "GEH inhibitor" RELATED [ChEBI] synonym: "GEH inhibitors" RELATED [ChEBI] synonym: "glycerol ester hydrolase inhibitor" RELATED [ChEBI] synonym: "glycerol ester hydrolase inhibitors" RELATED [ChEBI] synonym: "glycerol-ester hydrolase inhibitor" RELATED [ChEBI] synonym: "glycerol-ester hydrolase inhibitors" RELATED [ChEBI] synonym: "heparin releasable hepatic lipase inhibitor" RELATED [ChEBI] synonym: "heparin releasable hepatic lipase inhibitors" RELATED [ChEBI] synonym: "hepatic lipase inhibitor" RELATED [ChEBI] synonym: "hepatic lipase inhibitors" RELATED [ChEBI] synonym: "hepatic monoacylglycerol acyltransferase inhibitor" RELATED [ChEBI] synonym: "hepatic monoacylglycerol acyltransferase inhibitors" RELATED [ChEBI] synonym: "lipase inhibitor" RELATED [ChEBI] synonym: "lipase inhibitors" RELATED [ChEBI] synonym: "lipazin inhibitor" RELATED [ChEBI] synonym: "lipazin inhibitors" RELATED [ChEBI] synonym: "liver lipase inhibitor" RELATED [ChEBI] synonym: "liver lipase inhibitors" RELATED [ChEBI] synonym: "pancreatic lipase inhibitor" RELATED [ChEBI] synonym: "pancreatic lipase inhibitors" RELATED [ChEBI] synonym: "pancreatic triacylglycerol lipase inhibitor" RELATED [ChEBI] synonym: "pancreatic triacylglycerol lipase inhibitors" RELATED [ChEBI] synonym: "post-heparin plasma protamine-resistant lipase inhibitor" RELATED [ChEBI] synonym: "post-heparin plasma protamine-resistant lipase inhibitors" RELATED [ChEBI] synonym: "PPL inhibitor" RELATED [ChEBI] synonym: "PPL inhibitors" RELATED [ChEBI] synonym: "salt-resistant post-heparin lipase inhibitor" RELATED [ChEBI] synonym: "salt-resistant post-heparin lipase inhibitors" RELATED [ChEBI] synonym: "steapsin inhibitor" RELATED [ChEBI] synonym: "steapsin inhibitors" RELATED [ChEBI] synonym: "triacetinase inhibitor" RELATED [ChEBI] synonym: "triacetinase inhibitors" RELATED [ChEBI] synonym: "triacylglycerol ester hydrolase inhibitor" RELATED [ChEBI] synonym: "triacylglycerol ester hydrolase inhibitors" RELATED [ChEBI] synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitor" RELATED [ChEBI] synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitors" RELATED [ChEBI] synonym: "triacylglycerol lipase inhibitor" RELATED [ChEBI] synonym: "triacylglycerol lipase inhibitors" RELATED [ChEBI] synonym: "tributyrase inhibitor" RELATED [ChEBI] synonym: "tributyrase inhibitors" RELATED [ChEBI] synonym: "tributyrin esterase inhibitor" RELATED [ChEBI] synonym: "tributyrin esterase inhibitors" RELATED [ChEBI] synonym: "tributyrinase inhibitor" RELATED [ChEBI] synonym: "tributyrinase inhibitors" RELATED [ChEBI] synonym: "triglyceridase inhibitor" RELATED [ChEBI] synonym: "triglyceridase inhibitors" RELATED [ChEBI] synonym: "triglyceride hydrolase inhibitor" RELATED [ChEBI] synonym: "triglyceride hydrolase inhibitors" RELATED [ChEBI] synonym: "triglyceride lipase inhibitor" RELATED [ChEBI] synonym: "triglyceride lipase inhibitors" RELATED [ChEBI] synonym: "triolein hydrolase inhibitor" RELATED [ChEBI] synonym: "triolein hydrolase inhibitors" RELATED [ChEBI] synonym: "Tween hydrolase inhibitor" RELATED [ChEBI] synonym: "Tween hydrolase inhibitors" RELATED [ChEBI] synonym: "tween-hydrolysing esterase inhibitor" RELATED [ChEBI] synonym: "tween-hydrolyzing esterase inhibitors" RELATED [ChEBI] synonym: "Tweenase inhibitor" RELATED [ChEBI] synonym: "Tweenase inhibitors" RELATED [ChEBI] synonym: "Tweenesterase inhibitor" RELATED [ChEBI] synonym: "Tweenesterase inhibitors" RELATED [ChEBI] is_a: CHEBI:76773 ! EC 3.1.1.* (carboxylic ester hydrolase) inhibitor [Term] id: CHEBI:65023 name: anti-asthmatic agent namespace: chebi_ontology def: "Any compound that has anti-asthmatic effects." [] subset: 3_STAR synonym: "anti-asthmatic agents" RELATED [ChEBI] synonym: "antiasthmatic agent" RELATED [ChEBI] synonym: "antiasthmatic agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:65076 name: neamine(4+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the four free amino groups of neamine; major species at pH 7.3." [] subset: 3_STAR synonym: "neamine" RELATED [UniProt] synonym: "neaminium tetracation" RELATED [ChEBI] synonym: "neaminium(4+)" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:7489 ! neamine [Term] id: CHEBI:65077 name: neomycin C(6+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the six free amino groups of neomycin C; major species at pH 7.3." [] subset: 3_STAR synonym: "neomycin C" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:53634 ! neomycin C [Term] id: CHEBI:65212 name: polysaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is any derivative of a polysaccharide." [] subset: 3_STAR synonym: "polysaccharide derivatives" RELATED [ChEBI] is_a: CHEBI:167559 ! glycan is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:18154 ! polysaccharide [Term] id: CHEBI:65255 name: food preservative namespace: chebi_ontology def: "Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes." [] subset: 3_STAR synonym: "food preservatives" RELATED [ChEBI] is_a: CHEBI:64047 ! food additive [Term] id: CHEBI:65256 name: antimicrobial food preservative namespace: chebi_ontology def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." [] subset: 3_STAR synonym: "antimicrobial food preservatives" RELATED [ChEBI] synonym: "antimicrobial preservative" RELATED [ChEBI] synonym: "antimicrobial preservatives" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:65255 ! food preservative [Term] id: CHEBI:65259 name: GABA antagonist namespace: chebi_ontology def: "A compound that inhibits the action of gamma-aminobutyric acid." [] subset: 3_STAR synonym: "GABA antagonists" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor antagonist" RELATED [ChEBI] synonym: "gamma-aminobutyric acid receptor antagonists" RELATED [ChEBI] xref: Wikipedia:GABA_antagonist is_a: CHEBI:48706 ! antagonist is_a: CHEBI:51374 ! GABA agent [Term] id: CHEBI:65296 name: primary ammonium ion namespace: chebi_ontology def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." [] subset: 3_STAR synonym: "a primary amine" RELATED [UniProt] synonym: "substituted ammonium" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound [Term] id: CHEBI:67079 name: anti-inflammatory agent namespace: chebi_ontology def: "Any compound that has anti-inflammatory effects." [] subset: 3_STAR synonym: "anti-inflammatory agents" RELATED [ChEBI] synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application [Term] id: CHEBI:6827 name: methicillin namespace: chebi_ontology def: "A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "6beta-(2,6-dimethoxybenzamido)penicillanic acid" RELATED [ChEBI] synonym: "Methicillin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB01603 xref: KEGG:C07177 xref: Wikipedia:Meticillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:52064 ! methicillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:68452 name: azole namespace: chebi_ontology def: "Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen." [] subset: 3_STAR synonym: "azoles" RELATED [ChEBI] xref: Wikipedia:Azole is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38179 ! monocyclic heteroarene [Term] id: CHEBI:68481 name: mTOR inhibitor namespace: chebi_ontology def: "A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer." [] subset: 3_STAR synonym: "mammalian target of rapamycin inhibitor" RELATED [ChEBI] synonym: "mammalian target of rapamycin inhibitors" RELATED [ChEBI] synonym: "mTOR inhibitors" RELATED [ChEBI] xref: Wikipedia:MTOR_inhibitors is_a: CHEBI:37699 ! protein kinase inhibitor [Term] id: CHEBI:68495 name: apoptosis inducer namespace: chebi_ontology def: "Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms." [] subset: 3_STAR synonym: "apoptosis inducers" RELATED [ChEBI] synonym: "Type I cell-death inducer" RELATED [ChEBI] synonym: "Type I cell-death inducers" RELATED [ChEBI] synonym: "Type I programmed cell-death inducer" RELATED [ChEBI] synonym: "Type I programmed cell-death inducers" RELATED [ChEBI] is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:69136 name: latrunculin A namespace: chebi_ontology alt_id: CHEBI:43626 def: "A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes." [] subset: 3_STAR synonym: "(+)-latrunculin A" RELATED [ChEBI] synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" RELATED [PDBeChem] synonym: "LAT-A" RELATED [ChemIDplus] synonym: "LatA" RELATED [ChEBI] synonym: "LATRUNCULIN A" EXACT [PDBeChem] synonym: "NSC 613011" RELATED [ChemIDplus] xref: PDBeChem:LAR is_a: CHEBI:25106 ! macrolide is_a: CHEBI:46733 ! oxabicycloalkane is_a: CHEBI:48891 ! thiazolidinone is_a: CHEBI:59780 ! cyclic hemiketal relationship: RO:0000087 CHEBI:27026 ! has role toxin relationship: RO:0000087 CHEBI:70728 ! has role actin polymerisation inhibitor [Term] id: CHEBI:6923 name: miconazole namespace: chebi_ontology alt_id: CHEBI:108917 def: "A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes." [] subset: 3_STAR synonym: "(+-)-miconazole" RELATED [ChEBI] synonym: "(RS)-miconazole" RELATED [ChEBI] synonym: "1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole" RELATED [ChemIDplus] synonym: "1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole" RELATED [ChEMBL] synonym: "Daktarin IV" RELATED [ChemIDplus] synonym: "Miconazole" EXACT [KEGG_DRUG] synonym: "Monistat IV (TN)" RELATED [KEGG_DRUG] synonym: "rac-miconazole" RELATED [ChEBI] xref: DrugBank:DB01110 xref: KEGG:D00416 xref: Wikipedia:Miconazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87069 ! imidazole antifungal drug is_a: CHEBI:87071 ! conazole antifungal drug relationship: BFO:0000051 CHEBI:82894 ! has part (R)-miconazole relationship: BFO:0000051 CHEBI:82897 ! has part (S)-miconazole relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:82891 ! has role glucocorticoid receptor antagonist [Term] id: CHEBI:7025 name: mupirocin namespace: chebi_ontology alt_id: CHEBI:44038 def: "An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections." [] subset: 3_STAR synonym: "Pseudomonic acid A" RELATED [ChemIDplus] xref: DrugBank:DB00410 xref: HMDB:HMDB0014554 xref: KEGG:D01076 xref: Patent:DE2227739 xref: Patent:US3977943 xref: Patent:US4071536 xref: Wikipedia:Mupirocin is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:27136 ! triol is_a: CHEBI:32955 ! epoxide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:46942 ! oxanes is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester relationship: is_conjugate_acid_of CHEBI:145790 ! mupirocin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:70727 name: topoisomerase inhibitor namespace: chebi_ontology def: "An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA)." [] subset: 3_STAR synonym: "topoisomerase inhibitors" RELATED [ChEBI] xref: Wikipedia:Topoisomerase is_a: CHEBI:76830 ! EC 5.99.1.* (miscellaneous isomerase) inhibitor [Term] id: CHEBI:70728 name: actin polymerisation inhibitor namespace: chebi_ontology def: "Any substance that inhibits the polymerisation of the protein actin." [] subset: 3_STAR synonym: "actin polymerisation inhibitors" RELATED [ChEBI] synonym: "actin polymerization inhibitor" RELATED [ChEBI] synonym: "actin polymerization inhibitors" RELATED [ChEBI] synonym: "inhibitor of actin polymerization" RELATED [ChEBI] synonym: "inhibitors of actin polymerization" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor [Term] id: CHEBI:70977 name: alkane-alpha,omega-diammonium(2+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the amino groups of any alkane-alpha,omega-diamine; major species at pH 7.3." [] subset: 3_STAR synonym: "an alkane-alpha,omega-diamine" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:35411 ! alkane-alpha,omega-diamine [Term] id: CHEBI:71181 name: Sir2 inhibitor namespace: chebi_ontology def: "An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2." [] subset: 3_STAR synonym: "Sir2 inhibitors" RELATED [ChEBI] xref: Wikipedia:Sir2 is_a: CHEBI:61115 ! EC 3.5.1.98 (histone deacetylase) inhibitor [Term] id: CHEBI:71285 name: organophosphonate(2-) namespace: chebi_ontology def: "An organophosphonate oxoanion obtained by deprotonation of both phosphonate OH groups of any phosphonic acid." [] subset: 3_STAR synonym: "organophosphonate" RELATED [ChEBI] synonym: "organophosphonate dianion" RELATED [ChEBI] is_a: CHEBI:59635 ! organophosphonate oxoanion [Term] id: CHEBI:71300 name: EC 2.* (transferase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)" [] subset: 3_STAR synonym: "EC 2 inhibitor" RELATED [ChEBI] synonym: "EC 2 inhibitors" RELATED [ChEBI] synonym: "EC 2.* (transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.* inhibitor" RELATED [ChEBI] synonym: "EC 2.* inhibitors" RELATED [ChEBI] synonym: "transferase inhibitor" RELATED [ChEBI] synonym: "transferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Transferase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:71321 name: fusidate namespace: chebi_ontology def: "A steroid acid anion that is the conjugate base of fusidic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3." [] subset: 3_STAR synonym: "fusidate" EXACT [UniProt] synonym: "fusidine" RELATED [MetaCyc] synonym: "ramycin" RELATED [MetaCyc] is_a: CHEBI:50160 ! steroid acid anion relationship: is_conjugate_base_of CHEBI:29013 ! fusidic acid [Term] id: CHEBI:71337 name: minocycline(1-) namespace: chebi_ontology def: "An organic anion that is the conjugate base of minocycline, obtained by deprotonation of the two enolic hydroxy groups and protonation of the non-aromatic tertiary amino group." [] subset: 3_STAR synonym: "minocycline anion" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:50694 ! minocycline relationship: is_conjugate_base_of CHEBI:77906 ! minocycline zwitterion [Term] id: CHEBI:71339 name: novobiocin(1-) namespace: chebi_ontology def: "An organic anion that is the conjugate base of novobiocin." [] subset: 3_STAR synonym: "novobiocin" RELATED [UniProt] synonym: "novobiocin anion" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:28368 ! novobiocin [Term] id: CHEBI:71365 name: rifampicin zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 5-hydroxy group to the tertiary amino group of rifampicin; major species at pH 7.3." [] subset: 3_STAR synonym: "rifampicin" RELATED [UniProt] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:28077 ! rifampicin [Term] id: CHEBI:71392 name: tetracycline(1-) namespace: chebi_ontology def: "An organic anion that is the conjugate base of tetracycline zwitterion obtained by deprotonation of the two enolic hydroxy groups and protonation of the tertiary amino group." [] subset: 3_STAR synonym: "tetracycline anion" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion relationship: is_conjugate_base_of CHEBI:77932 ! tetracycline zwitterion [Term] id: CHEBI:71415 name: nitrofurantoin namespace: chebi_ontology alt_id: CHEBI:7591 def: "An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA." [] subset: 3_STAR synonym: "1-((5-Nitrofurfurylidene)amino)hydantoin" RELATED [ChemIDplus] synonym: "1-(5-Nitro-2-furfurylidenamino)hydantoin" RELATED [ChemIDplus] synonym: "1-(5-Nitro-2-furfurylideneamino)hydantoin" RELATED [ChemIDplus] synonym: "1-[(5-Nitrofurfurylidene)amino]hydantoin" RELATED [NIST_Chemistry_WebBook] synonym: "5-Nitrofurantoin" RELATED [NIST_Chemistry_WebBook] synonym: "N-(5-Nitrofurfurylidene)-1-aminohydantoin" RELATED [ChemIDplus] xref: DrugBank:DB00698 xref: KEGG:C07268 xref: KEGG:D00439 xref: Patent:US2610181 xref: Patent:US2898335 xref: Patent:US2927110 xref: Patent:WO2006019844 xref: Patent:WO2008103673 xref: Patent:WO2010065110 xref: Wikipedia:Nitrofurantoin is_a: CHEBI:24628 ! imidazolidine-2,4-dione is_a: CHEBI:87230 ! nitrofuran antibiotic relationship: has_functional_parent CHEBI:28306 ! semicarbazide relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent [Term] id: CHEBI:71543 name: rotenoid namespace: chebi_ontology def: "Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds." [] subset: 3_STAR synonym: "rotenoids" RELATED [ChEBI] xref: Wikipedia:Rotenoids is_a: CHEBI:72544 ! flavonoids is_a: CHEBI:72579 ! tetrahydrochromenochromene [Term] id: CHEBI:71629 name: nisin namespace: chebi_ontology def: "A type-A lantibiotic containing 34 amino acid residues (including lanthionine (Lan), methyllanthionine (MeLan), didehydroalanine (Dha) and didehydroaminobutyric acid (Dhb)) and five thioether bridges. It is obtained by fermentation of the bacterium Lactococcus lactis and shows particular activity against Clostridium botulinum. It is used in the production of various processed foods to suppress Gram-positive spoilage and pathogenic bacteria and so extend shelf life." [] subset: 3_STAR synonym: "E234" RELATED [ChEBI] synonym: "EINECS 215-807-5" RELATED [ChemIDplus] synonym: "NSC 112903" RELATED [ChemIDplus] synonym: "NSC-112903" RELATED [ChemIDplus] xref: Patent:US2935503 xref: Wikipedia:Nisin is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:71645 ! type A lantibiotic relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative [Term] id: CHEBI:71644 name: lantibiotic namespace: chebi_ontology def: "A class of peptide antibiotic characterised by the presence of the rare thioether amino acids lanthionine or methyllanthionine, as well as the unsaturated amino acids dehydroalanine and 2-aminoisobutyric acid. In contrast to classical peptide antibiotics, lantibiotics are synthesised from precursor genes using the ribosomal pathway and the characteristic rare amino acids are introduced by posttranslational modification procedues into the lantibiotic precursor peptides ('prepeptides'). Lantibiotics are subdivided into two types: type A have long, flexible structures, while type B have rigid, globular structures." [] subset: 3_STAR synonym: "lantibiotics" RELATED [ChEBI] xref: Wikipedia:Lantibiotics is_a: CHEBI:15841 ! polypeptide is_a: CHEBI:25903 ! peptide antibiotic [Term] id: CHEBI:71645 name: type A lantibiotic namespace: chebi_ontology def: "Any lantibiotic which has which has a long, flexible structure." [] subset: 3_STAR synonym: "type 1 lantibiotic" RELATED [ChEBI] synonym: "type 1 lantibiotics" RELATED [ChEBI] synonym: "type A lantibiotics" RELATED [ChEBI] synonym: "type-A lantibiotic" RELATED [ChEBI] synonym: "type-A lantibiotics" RELATED [ChEBI] is_a: CHEBI:71644 ! lantibiotic [Term] id: CHEBI:71989 name: ortho ester namespace: chebi_ontology def: "Any organooxygen compound that has the general formula RC(OR(1))(OR(2))(OR(3)), where R(1), R(2), R(3) =/= H." [] subset: 3_STAR synonym: "ortho esters" RELATED [ChEBI] synonym: "ortho-ester" RELATED [ChEBI] synonym: "ortho-esters" RELATED [ChEBI] synonym: "orthoester" RELATED [ChEBI] synonym: "orthoesters" RELATED [ChEBI] xref: Wikipedia:Orthoester is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:72316 name: virulence factor namespace: chebi_ontology def: "Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host." [] subset: 3_STAR synonym: "virulence factors" RELATED [ChEBI] xref: Wikipedia:Virulence_factor is_a: CHEBI:27026 ! toxin [Term] id: CHEBI:72544 name: flavonoids namespace: chebi_ontology def: "Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them." [] subset: 3_STAR synonym: "flavonoid" RELATED [ChEBI] xref: Wikipedia:Flavonoids is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72579 name: tetrahydrochromenochromene namespace: chebi_ontology def: "Any chromenochromene resulting from the formal cis-fusion of two dihydro chromene rings, together with their substituted derivatives." [] subset: 3_STAR synonym: "tetrahydrochromenochromenes" RELATED [ChEBI] is_a: CHEBI:133135 ! chromenochromene [Term] id: CHEBI:72581 name: rotenones namespace: chebi_ontology def: "Members of the class of rotenoid which consists of a 6a,12a-dihydrochromeno[3,4-b]chromen-12(6H)-one skeleton and its substituted products." [] subset: 3_STAR is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:71543 ! rotenoid [Term] id: CHEBI:72588 name: semisynthetic derivative namespace: chebi_ontology def: "Any organic molecular entity derived from a natural product by partial chemical synthesis." [] subset: 3_STAR synonym: "semi-synthetic compound" RELATED [ChEBI] synonym: "semi-synthetic compounds" RELATED [ChEBI] synonym: "semi-synthetic derivative" RELATED [ChEBI] synonym: "semi-synthetic derivatives" RELATED [ChEBI] synonym: "semisynthetic compound" RELATED [ChEBI] synonym: "semisynthetic compounds" RELATED [ChEBI] synonym: "semisynthetic derivatives" RELATED [ChEBI] xref: Wikipedia:Semisynthesis is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72600 name: spiroketal namespace: chebi_ontology def: "A cyclic ketal in which the ketal carbon is the only common atom of two rings." [] subset: 3_STAR synonym: "spiroacetal" RELATED [ChEBI] synonym: "spiroacetals" RELATED [ChEBI] synonym: "spiroketals" RELATED [ChEBI] is_a: CHEBI:37948 ! oxaspiro compound is_a: CHEBI:59779 ! cyclic ketal [Term] id: CHEBI:72695 name: organic molecule namespace: chebi_ontology def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." [] subset: 3_STAR synonym: "organic compound" RELATED [ChEBI] synonym: "organic compounds" RELATED [ChEBI] synonym: "organic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:72768 name: aryl hydrocarbon receptor agonist namespace: chebi_ontology def: "An agonist that binds to and activates aryl hydrocarbon receptors (AhRs)." [] subset: 3_STAR synonym: "AHR agonist" RELATED [ChEBI] synonym: "AhR agonist" RELATED [ChEBI] synonym: "AHR agonists" RELATED [ChEBI] synonym: "AhR agonists" RELATED [ChEBI] synonym: "aryl hydrocarbon receptor agonists" RELATED [ChEBI] is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:73080 name: hemiaminal namespace: chebi_ontology def: "Any organic amino compound that has an amino group and a hydroxy group attached to the same carbon atom. Hemiaminals are intermediates in the formation of imines by addition of an amine to an aldehyde or ketone; those derived from primary amines are particularly unstable." [] subset: 3_STAR synonym: "carbinolamine" RELATED [ChEBI] synonym: "carbinolamines" RELATED [ChEBI] synonym: "hemiaminals" RELATED [ChEBI] xref: Wikipedia:Hemiaminal is_a: CHEBI:33822 ! organic hydroxy compound is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:73181 name: EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor namespace: chebi_ontology def: "An EC 1.11.1.* (peroxidases) inhibitor that inhibits the action of L-ascorbate peroxidase (EC 1.11.1.11)." [] subset: 3_STAR synonym: "ascorbate peroxidase inhibitor" RELATED [ChEBI] synonym: "ascorbate peroxidase inhibitors" RELATED [ChEBI] synonym: "ascorbic acid peroxidase inhibitor" RELATED [ChEBI] synonym: "ascorbic acid peroxidase inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.11 inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1.11 inhibitors" RELATED [ChEBI] synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitor" RELATED [ChEBI] synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitors" RELATED [ChEBI] synonym: "L-ascorbate peroxidase inhibitor" RELATED [ChEBI] synonym: "L-ascorbate peroxidase inhibitors" RELATED [ChEBI] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitor" RELATED [ChEBI] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors" RELATED [ChEBI] synonym: "L-ascorbic acid peroxidase inhibitor" RELATED [ChEBI] synonym: "L-ascorbic acid peroxidase inhibitors" RELATED [ChEBI] synonym: "L-ascorbic acid-specific peroxidase inhibitor" RELATED [ChEBI] synonym: "L-ascorbic acid-specific peroxidase inhibitors" RELATED [ChEBI] xref: Wikipedia:L-ascorbate_peroxidase is_a: CHEBI:75381 ! EC 1.11.1.* (peroxidases) inhibitor [Term] id: CHEBI:73216 name: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor namespace: chebi_ontology alt_id: CHEBI:76765 def: "Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*)." [] subset: 3_STAR synonym: "acid anhydride hydrolase inhibitor" RELATED [ChEBI] synonym: "acid anhydride hydrolase inhibitors" RELATED [ChEBI] synonym: "EC 3.6 inhibitor" RELATED [ChEBI] synonym: "EC 3.6 inhibitors" RELATED [ChEBI] synonym: "EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.* inhibitor" RELATED [ChEBI] synonym: "EC 3.6.* inhibitors" RELATED [ChEBI] synonym: "EC 3.6.*.* inhibitor" RELATED [ChEBI] synonym: "EC 3.6.*.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [ChEBI] synonym: "inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:73336 name: vulnerary namespace: chebi_ontology def: "A drug used in treating and healing of wounds." [] subset: 3_STAR synonym: "vulneraries" RELATED [ChEBI] synonym: "wound-healing agent" RELATED [ChEBI] synonym: "wound-healing agents" RELATED [ChEBI] synonym: "wound-healing drug" RELATED [ChEBI] synonym: "wound-healing drugs" RELATED [ChEBI] xref: Wikipedia:Wound_healing is_a: CHEBI:23888 ! drug [Term] id: CHEBI:73474 name: acetylenic compound namespace: chebi_ontology def: "Any organic molecule containing a C#C bond." [] subset: 3_STAR synonym: "acetylenic compounds" RELATED [ChEBI] synonym: "C#C containing compound" RELATED [ChEBI] synonym: "C#C containing compounds" RELATED [ChEBI] synonym: "C#C-containing compound" RELATED [ChEBI] synonym: "C#C-containing compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule [Term] id: CHEBI:73537 name: 1,8-naphthyridine derivative namespace: chebi_ontology def: "Any naphthyridine derivative that is a derivative of 1,8-naphthyridine." [] subset: 3_STAR synonym: "1,8-naphthyridine derivatives" RELATED [ChEBI] is_a: CHEBI:73539 ! naphthyridine derivative relationship: has_parent_hydride CHEBI:36628 ! 1,8-naphthyridine [Term] id: CHEBI:73539 name: naphthyridine derivative namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound that is a derivative of a naphthyridine." [] subset: 3_STAR synonym: "naphthyridine derivatives" RELATED [ChEBI] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound relationship: has_parent_hydride CHEBI:36624 ! naphthyridine [Term] id: CHEBI:73678 name: tobramycin(5+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the five amino groups of tobramycin." [] subset: 3_STAR synonym: "tobramycin" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28864 ! tobramycin [Term] id: CHEBI:73754 name: thiosugar namespace: chebi_ontology def: "A carbohydrate derivative in which one or more of the oxygens or hydroxy groups of the parent carbohydrate is replaced by sulfur or -SR, where R can be hydrogen or any group." [] subset: 3_STAR synonym: "thiosugars" RELATED [ChEBI] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:63299 ! carbohydrate derivative [Term] id: CHEBI:73913 name: antifolate namespace: chebi_ontology def: "An antimetabolite that impairs the action of folic acids" [] subset: 3_STAR synonym: "antifolates" RELATED [ChEBI] synonym: "folic acid antagonist" RELATED [ChEBI] synonym: "folic acid antagonists" RELATED [ChEBI] xref: Wikipedia:Antifolate is_a: CHEBI:35221 ! antimetabolite [Term] id: CHEBI:74159 name: D-cycloserine zwitterion namespace: chebi_ontology def: "A zwitterion resulting from the transfer of a proton from the ring nitrogen to the primary amino group of D-cycloserine. The major species at pH 7.3." [] subset: 3_STAR synonym: "(+)-4-amino-3-isoxazolidinone zwitterion" RELATED [ChEBI] synonym: "(4R)-4-aminoisoxazolidin-3-one zwitterion" RELATED [ChEBI] synonym: "alpha-cycloserine zwitterion" RELATED [ChEBI] synonym: "cycloserine zwitterion" RELATED [ChEBI] synonym: "D-4-amino-3-isoxazolidinone zwitterion" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:40009 ! D-cycloserine [Term] id: CHEBI:7451 name: naftifine namespace: chebi_ontology def: "A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections." [] subset: 3_STAR synonym: "(E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine" RELATED [ChemIDplus] synonym: "naftifin" RELATED [ChemIDplus] synonym: "trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine" RELATED [ChEBI] xref: DrugBank:DB00735 xref: HMDB:HMDB0014873 xref: KEGG:C08071 xref: KEGG:D08245 xref: Patent:BE853976 xref: Patent:US4282251 xref: Wikipedia:Naftifine is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:32876 ! tertiary amine is_a: CHEBI:87127 ! allylamine antifungal drug relationship: RO:0000087 CHEBI:59285 ! has role EC 1.14.13.132 (squalene monooxygenase) inhibitor relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor [Term] id: CHEBI:74783 name: astringent namespace: chebi_ontology def: "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." [] subset: 3_STAR synonym: "adstringent" RELATED [ChEBI] synonym: "adstringents" RELATED [ChEBI] synonym: "astringents" RELATED [ChEBI] xref: Wikipedia:Astringent is_a: CHEBI:23888 ! drug [Term] id: CHEBI:74818 name: heteroaryl hydroxy compound namespace: chebi_ontology def: "Any organic aromatic compound having one or more hydroxy groups attached to a heteroarene ring." [] subset: 3_STAR synonym: "hetaryl hydroxy compound" RELATED [ChEBI] synonym: "hetaryl hydroxy compounds" RELATED [ChEBI] synonym: "heteroaromatic hydroxy compound" RELATED [ChEBI] synonym: "heteroaromatic hydroxy compounds" RELATED [ChEBI] synonym: "heteroaryl hydroxy compounds" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound [Term] id: CHEBI:7489 name: neamine namespace: chebi_ontology alt_id: CHEBI:46591 alt_id: CHEBI:481318 def: "2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group." [] subset: 3_STAR synonym: "2-desoxy-4-O-(2,6-diamino-2,6-didesoxy-alpha-D-glucopyranosyl)-D-streptamin" RELATED [ChemIDplus] synonym: "4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine" RELATED [ChemIDplus] synonym: "Neamine" EXACT [KEGG_COMPOUND] synonym: "neamine" EXACT [ChEMBL] synonym: "Neomycin A" RELATED [KEGG_COMPOUND] xref: DrugBank:DB04808 xref: KEGG:C01441 xref: PDBeChem:XXX is_a: CHEBI:47779 ! aminoglycoside is_a: CHEBI:53628 ! 2,6-dideoxy-alpha-D-glucoside relationship: is_conjugate_base_of CHEBI:65076 ! neamine(4+) relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent [Term] id: CHEBI:7507 name: neomycin namespace: chebi_ontology def: "A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (Streptomyces fradiae) and used medically especially to treat local infections." [] subset: 3_STAR synonym: "Neomycin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00994 xref: KEGG:C00384 xref: KEGG:D08260 is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic relationship: BFO:0000051 CHEBI:53634 ! has part neomycin C relationship: BFO:0000051 CHEBI:7489 ! has part neamine relationship: BFO:0000051 CHEBI:7508 ! has part framycetin [Term] id: CHEBI:7508 name: framycetin namespace: chebi_ontology alt_id: CHEBI:44577 def: "A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B." [] subset: 3_STAR synonym: "Fradiomycin B" RELATED [KEGG_COMPOUND] synonym: "Framycetin" EXACT [ChemIDplus, KEGG_COMPOUND] synonym: "Neomycin B" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00452 xref: KEGG:C01737 xref: KEGG:D05140 xref: LINCS:LSM-5787 xref: MetaCyc:CPD-14142 xref: PDBeChem:NMY xref: VSDB:1783 is_a: CHEBI:47779 ! aminoglycoside relationship: is_conjugate_base_of CHEBI:87835 ! framycetin(6+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50904 ! has role allergen relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite [Term] id: CHEBI:7528 name: netilmycin namespace: chebi_ontology subset: 3_STAR synonym: "1-N-Ethylsisomicin" RELATED [ChemIDplus] synonym: "Netilmicin" RELATED [KEGG_COMPOUND] synonym: "O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-N(1)-ethyl-D-streptamine" RELATED [ChemIDplus] xref: DrugBank:DB00955 xref: KEGG:C07657 xref: KEGG:D08268 is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic is_a: CHEBI:28079 ! beta-L-arabinoside is_a: CHEBI:63367 ! monosaccharide derivative relationship: has_functional_parent CHEBI:27955 ! streptamine [Term] id: CHEBI:75282 name: ergosterol biosynthesis inhibitor namespace: chebi_ontology def: "Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol." [] subset: 3_STAR synonym: "ergosterol biosynthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:83317 ! sterol biosynthesis inhibitor [Term] id: CHEBI:75283 name: miltefosine namespace: chebi_ontology def: "A phospholipid that is the hexadecyl monoester of phosphocholine." [] subset: 3_STAR synonym: "Hexadecylphosphocholine" RELATED [ChemIDplus] synonym: "Hexadecylphosphorylcholine" RELATED [ChemIDplus] synonym: "monohexadecylphosphocholine" RELATED [ChEBI] synonym: "monohexadecylphosphorylcholine" RELATED [ChEBI] xref: KEGG:D02494 xref: Wikipedia:Miltefosine is_a: CHEBI:16247 ! phospholipid is_a: CHEBI:36700 ! phosphocholines relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:37699 ! has role protein kinase inhibitor relationship: RO:0000087 CHEBI:50846 ! has role immunomodulator relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer [Term] id: CHEBI:75381 name: EC 1.11.1.* (peroxidases) inhibitor namespace: chebi_ontology def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any of the peroxidases (EC 1.11.1.*)." [] subset: 3_STAR synonym: "EC 1.11.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1 inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.* (peroxidase) inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1.* (peroxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.* (peroxidases) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.11.1.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of peroxidases" RELATED [ChEBI] synonym: "inhibitors of peroxidases" RELATED [ChEBI] synonym: "peroxidases inhibitors" RELATED [ChEBI] xref: Wikipedia:Peroxidases is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor [Term] id: CHEBI:75592 name: L-cycloserine namespace: chebi_ontology def: "A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora." [] subset: 3_STAR synonym: "(-)-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "(-)-4-aminoisoxazolidin-3-one" RELATED [ChEBI] synonym: "(-)-cycloserine" RELATED [ChEBI] synonym: "(4S)-4-aminoisoxazolidin-3-one" RELATED [IUPAC] synonym: "(S)-(-)-cycloserine" RELATED [ChemIDplus] synonym: "(S)-4-amino-3-isoxazolidinone" RELATED [ChemIDplus] synonym: "(S)-4-amino-isoxazolidin-3-one" RELATED [ChEBI] synonym: "cyclo-L-serine" RELATED [ChemIDplus] synonym: "L-4-aminoisoxazolidin-3-one" RELATED [ChEBI] synonym: "L-CS" RELATED [ChEBI] xref: DrugBank:DB00260 xref: HMDB:HMDB0014405 xref: KEGG:D04706 xref: LINCS:LSM-5639 xref: MetaCyc:CPD-2483 is_a: CHEBI:23503 ! 4-amino-1,2-oxazolidin-3-one relationship: is_enantiomer_of CHEBI:40009 ! D-cycloserine relationship: RO:0000087 CHEBI:35623 ! has role anticonvulsant relationship: RO:0000087 CHEBI:59647 ! has role EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor relationship: RO:0000087 CHEBI:64946 ! has role anti-HIV agent [Term] id: CHEBI:75596 name: EC 5.* (isomerase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*)." [] subset: 3_STAR synonym: "EC 5.* (isomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.* inhibitor" RELATED [ChEBI] synonym: "EC 5.* inhibitors" RELATED [ChEBI] synonym: "EC 5.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 5.*.*.* inhibitors" RELATED [ChEBI] synonym: "isomerase (EC 5.*) inhibitor" RELATED [ChEBI] synonym: "isomerase (EC 5.*) inhibitors" RELATED [ChEBI] synonym: "isomerase inhibitor" RELATED [ChEBI] synonym: "isomerase inhibitors" RELATED [ChEBI] is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:75606 name: hydroxamic acid ester namespace: chebi_ontology def: "A carboxamide that is a hydroxamic acid in which the hydrogen of the hydroxy group is replaced by an organyl group." [] subset: 3_STAR synonym: "hydroxamate ester" RELATED [ChEBI] synonym: "hydroxamate esters" RELATED [ChEBI] synonym: "hydroxamic acid esters" RELATED [ChEBI] synonym: "RC(O)NHOR'" RELATED [ChEBI] synonym: "RCONHOR'" RELATED [ChEBI] is_a: CHEBI:37622 ! carboxamide relationship: has_functional_parent CHEBI:24650 ! hydroxamic acid [Term] id: CHEBI:75616 name: gentamicin C(5+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the five amino groups of any gentamicin C." [] subset: 3_STAR synonym: "gentamicin C" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:28417 ! gentamycin C [Term] id: CHEBI:7566 name: Nifurtimox namespace: chebi_ontology subset: 2_STAR synonym: "Bayer 2502" RELATED [DrugCentral] synonym: "lampit" RELATED [DrugCentral] synonym: "Nifurtimox" EXACT [KEGG_COMPOUND] xref: KEGG:C08002 xref: KEGG:D00833 is_a: CHEBI:87230 ! nitrofuran antibiotic [Term] id: CHEBI:75763 name: eukaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." [] subset: 3_STAR synonym: "eukaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:75767 name: animal metabolite namespace: chebi_ontology alt_id: CHEBI:77721 alt_id: CHEBI:77743 def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." [] subset: 3_STAR synonym: "animal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:75768 name: mammalian metabolite namespace: chebi_ontology alt_id: CHEBI:77464 alt_id: CHEBI:77744 def: "Any animal metabolite produced during a metabolic reaction in mammals." [] subset: 3_STAR synonym: "mammalian metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:75769 name: B vitamin namespace: chebi_ontology def: "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." [] subset: 3_STAR synonym: "B vitamins" RELATED [ChEBI] synonym: "B-group vitamin" RELATED [ChEBI] synonym: "B-group vitamins" RELATED [ChEBI] synonym: "vitamin B" RELATED [ChEBI] xref: MetaCyc:B-vitamins xref: Wikipedia:B_vitamin is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound relationship: RO:0000087 CHEBI:27314 ! has role water-soluble vitamin (role) relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical [Term] id: CHEBI:75771 name: mouse metabolite namespace: chebi_ontology def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." [] subset: 3_STAR synonym: "mouse metabolites" RELATED [ChEBI] synonym: "Mus musculus metabolite" RELATED [ChEBI] synonym: "Mus musculus metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:75772 name: Saccharomyces cerevisiae metabolite namespace: chebi_ontology alt_id: CHEBI:76949 alt_id: CHEBI:76951 def: "Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." [] subset: 3_STAR synonym: "baker's yeast metabolite" RELATED [ChEBI] synonym: "baker's yeast metabolites" RELATED [ChEBI] synonym: "baker's yeast secondary metabolite" RELATED [ChEBI] synonym: "baker's yeast secondary metabolites" RELATED [ChEBI] synonym: "S. cerevisiae metabolite" RELATED [ChEBI] synonym: "S. cerevisiae metabolites" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI] synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI] synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI] is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:75787 name: prokaryotic metabolite namespace: chebi_ontology def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." [] subset: 3_STAR synonym: "prokaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:75929 name: D-cycloserine(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of D-cycloserine, obtained by protonation of the amino group." [] subset: 3_STAR synonym: "D-cycloserine" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:40009 ! D-cycloserine [Term] id: CHEBI:75954 name: vancomycin aglycone zwitterion namespace: chebi_ontology def: "A peptide zwitterion obtained by transfer of a proton from the carboxy to the amino group of vancomycin aglycone." [] subset: 3_STAR is_a: CHEBI:60466 ! peptide zwitterion relationship: is_conjugate_acid_of CHEBI:77981 ! vancomycin aglycone(1-) relationship: is_tautomer_of CHEBI:47724 ! vancomycin aglycone [Term] id: CHEBI:76042 name: aromatic amino-acid zwitterion namespace: chebi_ontology def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid." [] subset: 3_STAR synonym: "an aromatic amino-acid" RELATED [UniProt] synonym: "aromatic amino-acid zwitterions" RELATED [ChEBI] is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:33856 ! aromatic amino acid [Term] id: CHEBI:76206 name: xenobiotic metabolite namespace: chebi_ontology def: "Any metabolite produced by metabolism of a xenobiotic compound." [] subset: 3_STAR synonym: "xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76395 name: EC 2.3.1.48 (histone acetyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48)." [] subset: 3_STAR synonym: "acetyl-CoA:histone acetyltransferase inhibitor" RELATED [ChEBI] synonym: "acetyl-CoA:histone acetyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.48 (histone acetyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.48 inhibitor" RELATED [ChEBI] synonym: "EC 2.3.1.48 inhibitors" RELATED [ChEBI] synonym: "HAT inhibitor" RELATED [ChEBI] synonym: "HAT inhibitors" RELATED [ChEBI] synonym: "histone acetokinase inhibitor" RELATED [ChEBI] synonym: "histone acetokinase inhibitors" RELATED [ChEBI] synonym: "histone acetylase inhibitor" RELATED [ChEBI] synonym: "histone acetylase inhibitors" RELATED [ChEBI] synonym: "histone acetyltransferase (EC 2.3.1.48) inhibitor" RELATED [ChEBI] synonym: "histone acetyltransferase (EC 2.3.1.48) inhibitors" RELATED [ChEBI] synonym: "histone acetyltransferase inhibitor" RELATED [ChEBI] synonym: "histone acetyltransferase inhibitors" RELATED [ChEBI] synonym: "histone transacetylase inhibitor" RELATED [ChEBI] synonym: "histone transacetylase inhibitors" RELATED [ChEBI] synonym: "nucleosome-histone acetyltransferase inhibitor" RELATED [ChEBI] synonym: "nucleosome-histone acetyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Histone_acetyltransferase is_a: CHEBI:76878 ! EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor [Term] id: CHEBI:76507 name: marine metabolite namespace: chebi_ontology alt_id: CHEBI:77078 def: "Any metabolite produced during a metabolic reaction in marine macro- and microorganisms." [] subset: 3_STAR synonym: "marine metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:76567 name: polyunsaturated fatty acid anion namespace: chebi_ontology def: "Any unsaturated fatty acid anion containing more than one C-C unsaturated bond. Major species at pH 7.3." [] subset: 3_STAR synonym: "polyunsaturated fatty acid anions" RELATED [ChEBI] synonym: "PUFA" RELATED [SUBMITTER] is_a: CHEBI:2580 ! unsaturated fatty acid anion relationship: is_conjugate_base_of CHEBI:26208 ! polyunsaturated fatty acid [Term] id: CHEBI:7660 name: nystatin namespace: chebi_ontology def: "A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections." [] subset: 3_STAR xref: DrugBank:DB00646 xref: KEGG:C06572 xref: KEGG:D00202 xref: Wikipedia:Nystatin is_a: CHEBI:22507 ! aminoglycoside antibiotic is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26191 ! polyol is_a: CHEBI:36244 ! dicarboxylic acid monoester is_a: CHEBI:48121 ! polyene is_a: CHEBI:60004 ! mixture is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: BFO:0000051 CHEBI:192979 ! has part nystatin A2 relationship: BFO:0000051 CHEBI:31927 ! has part nystatin A3 relationship: BFO:0000051 CHEBI:473992 ! has part nystatin A1 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:76661 name: EC 2.3.* (acyltransferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that interferes with the action of an acyltransferase (EC 2.3.*.*)." [] subset: 3_STAR synonym: "acyltransferase inhibitor" RELATED [ChEBI] synonym: "acyltransferase inhibitors" RELATED [ChEBI] synonym: "EC 2.3.* (acyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.* inhibitor" RELATED [ChEBI] synonym: "EC 2.3.* inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76662 name: EC 2.4.* (glycosyltransferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor inhibiting the action of a glycosyltransferase (EC 2.4.*.*)." [] subset: 3_STAR synonym: "EC 2.4.* (glycosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.* inhibitor" RELATED [ChEBI] synonym: "EC 2.4.* inhibitors" RELATED [ChEBI] synonym: "glycosyltransferase (EC 2.4.*) inhibitor" RELATED [ChEBI] synonym: "glycosyltransferase (EC 2.4.*) inhibitors" RELATED [ChEBI] synonym: "glycosyltransferase inhibitor" RELATED [ChEBI] synonym: "glycosyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76663 name: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*)." [] subset: 3_STAR synonym: "alkyl/aryl (non-methyl) transferase inhibitor" RELATED [ChEBI] synonym: "alkyl/aryl (non-methyl) transferase inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.5.1.* inhibitors" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase inhibitor" RELATED [ChEBI] synonym: "non-methyl alkyl/aryl transferase inhibitors" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase inhibitor" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76834 ! EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor [Term] id: CHEBI:76668 name: EC 2.7.* (P-containing group transferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*)." [] subset: 3_STAR synonym: "EC 2.7.* (P-containing group transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitor" RELATED [ChEBI] synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.* inhibitors" RELATED [ChEBI] synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitor" RELATED [ChEBI] synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitors" RELATED [ChEBI] synonym: "phosphorus-containing group transferase inhibitor" RELATED [ChEBI] synonym: "phosphorus-containing group transferase inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76697 name: EC 5.99.* (other isomerases) inhibitor namespace: chebi_ontology def: "An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*)." [] subset: 3_STAR synonym: "EC 5.99.* (miscellaneous isomerases) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.* (miscellaneous isomerases) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.* (other isomerase) inhibitor" RELATED [ChEBI] synonym: "EC 5.99.* (other isomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.* (other isomerases) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.* inhibitor" RELATED [ChEBI] synonym: "EC 5.99.* inhibitors" RELATED [ChEBI] is_a: CHEBI:75596 ! EC 5.* (isomerase) inhibitor [Term] id: CHEBI:76710 name: EC 4.* (lyase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation." [] subset: 3_STAR synonym: "EC 4.* (lyase) inhibitors" RELATED [ChEBI] synonym: "EC 4.* inhibitor" RELATED [ChEBI] synonym: "EC 4.* inhibitors" RELATED [ChEBI] synonym: "EC 4.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 4.*.*.* inhibitors" RELATED [ChEBI] synonym: "lyase (EC 4.*) inhibitor" RELATED [ChEBI] synonym: "lyase (EC 4.*) inhibitorS" RELATED [ChEBI] synonym: "lyase inhibitor" RELATED [ChEBI] synonym: "lyase inhibitors" RELATED [ChEBI] xref: Wikipedia:Lyase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76712 name: EC 4.2.* (C-O lyase) inhibitor namespace: chebi_ontology def: "A lyase inhibitor which inhibits the action of a C-O lyase (EC 4.2.*.*)." [] subset: 3_STAR synonym: "C-O lyase (EC 4.2.*) inhibitor" RELATED [ChEBI] synonym: "C-O lyase (EC 4.2.*) inhibitors" RELATED [ChEBI] synonym: "C-O lyase inhibitor" RELATED [ChEBI] synonym: "C-O lyase inhibitors" RELATED [ChEBI] synonym: "EC 4.2.* (C-O lyase) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.* inhibitor" RELATED [ChEBI] synonym: "EC 4.2.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76710 ! EC 4.* (lyase) inhibitor [Term] id: CHEBI:76725 name: EC 1.* (oxidoreductase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." [] subset: 3_STAR synonym: "EC 1.* (oxidoreductase) inhibitors" RELATED [ChEBI] synonym: "EC 1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase (EC 1.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase (EC 1.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase inhibitor" RELATED [ChEBI] synonym: "oxidoreductase inhibitors" RELATED [ChEBI] xref: Wikipedia:Oxidoreductase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76727 name: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*)." [] subset: 3_STAR synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor" RELATED [ChEBI] synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.* inhibitor" RELATED [ChEBI] synonym: "EC 1.2.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76729 name: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*)." [] subset: 3_STAR synonym: "EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.3.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-CH group inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76730 name: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH2 group of donors (EC 1.4.*.*)." [] subset: 3_STAR synonym: "EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor" EXACT [ChEBI] synonym: "EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.* inhibitor" RELATED [ChEBI] synonym: "EC 1.4.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH2 group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH2 group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH2 group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH2 group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donor inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donor inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76731 name: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*)." [] subset: 3_STAR synonym: "EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors" RELATED [ChEBI] synonym: "EC 1.5.* inhibitor" RELATED [ChEBI] synonym: "EC 1.5.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76733 name: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on NADH or NADPH (EC 1.6.*.*)." [] subset: 3_STAR synonym: "EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on NADH or NADPH" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on NADH or NADPH" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76736 name: EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on a heme group of donors (EC 1.9.*.*)." [] subset: 3_STAR synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitor" RELATED [ChEBI] synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.* (oxidoreductase acting on donor heme group) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.* inhibitor" RELATED [ChEBI] synonym: "EC 1.9.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76738 name: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on peroxide as donors (EC 1.11.*.*)." [] subset: 3_STAR synonym: "EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitor" RELATED [ChEBI] synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.* inhibitor" RELATED [ChEBI] synonym: "EC 1.11.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76740 name: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*." [] subset: 3_STAR synonym: "EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors" RELATED [ChEBI] synonym: "EC 1.13.* inhibitor" RELATED [ChEBI] synonym: "EC 1.13.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76741 name: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor namespace: chebi_ontology def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*)." [] subset: 3_STAR synonym: "EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.* inhibitor" RELATED [ChEBI] synonym: "EC 1.14.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors" RELATED [ChEBI] is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor [Term] id: CHEBI:76759 name: EC 3.* (hydrolase) inhibitor namespace: chebi_ontology def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." [] subset: 3_STAR synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.* inhibitors" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI] synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI] synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI] synonym: "hydrolase inhibitor" RELATED [ChEBI] synonym: "hydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Hydrolase is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76760 name: EC 3.1.* (ester hydrolase) inhibitor namespace: chebi_ontology def: "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." [] subset: 3_STAR synonym: "EC 3.1.* (ester hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.1.* inhibitors" RELATED [ChEBI] synonym: "ester hydrolase (EC 3.1.*) inhibitor" RELATED [ChEBI] synonym: "ester hydrolase (EC 3.1.*) inhibitors" RELATED [ChEBI] synonym: "ester hydrolase inhibitor" RELATED [ChEBI] synonym: "ester hydrolase inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:76764 name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor namespace: chebi_ontology def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." [] subset: 3_STAR synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor [Term] id: CHEBI:76773 name: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*)." [] subset: 3_STAR synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitor" RELATED [ChEBI] synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.* (carboxylic ester hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.1.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor [Term] id: CHEBI:76775 name: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*)." [] subset: 3_STAR synonym: "EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.1.3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.1.3.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of phosphoric monoester hydrolase" RELATED [ChEBI] synonym: "inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI] synonym: "inhibitors of phosphoric monoester hydrolase" RELATED [ChEBI] synonym: "inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase inhibitor" RELATED [ChEBI] synonym: "phosphoric monoester hydrolase inhibitors" RELATED [ChEBI] is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor [Term] id: CHEBI:76789 name: EC 2.4.1.* (hexosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any hexosyltransferase (EC 2.4.1.*)." [] subset: 3_STAR synonym: "EC 2.4.1.* (hexosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.4.1.* inhibitors" RELATED [ChEBI] synonym: "hexosyltransferase (EC 2.4.1.*) inhibitor" RELATED [ChEBI] synonym: "hexosyltransferase (EC 2.4.1.*) inhibitors" RELATED [ChEBI] synonym: "hexosyltransferase inhibitor" RELATED [ChEBI] synonym: "hexosyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76662 ! EC 2.4.* (glycosyltransferase) inhibitor [Term] id: CHEBI:76790 name: EC 2.4.2.* (pentosyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any pentosyltransferase (EC 2.4.2.*)." [] subset: 3_STAR synonym: "EC 2.4.2.* (pentosyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.4.2.* inhibitor" RELATED [ChEBI] synonym: "EC 2.4.2.* inhibitors" RELATED [ChEBI] synonym: "pentosyltransferase (EC 2.4.2.*) inhibitor" RELATED [ChEBI] synonym: "pentosyltransferase (EC 2.4.2.*) inhibitors" RELATED [ChEBI] synonym: "pentosyltransferase inhibitor" RELATED [ChEBI] synonym: "pentosyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76662 ! EC 2.4.* (glycosyltransferase) inhibitor [Term] id: CHEBI:76807 name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." [] subset: 3_STAR synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI] synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor [Term] id: CHEBI:76808 name: EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor namespace: chebi_ontology def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*)." [] subset: 3_STAR synonym: "EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.2.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.2.* inhibitors" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitor" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase inhibitor" RELATED [ChEBI] synonym: "non-peptide cyclic amide C-N hydrolase inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor [Term] id: CHEBI:76812 name: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*)." [] subset: 3_STAR synonym: "EC 2.7.11.* (protein-serine/threonine kinase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.11.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.11.* inhibitors" RELATED [ChEBI] synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitor" RELATED [ChEBI] synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitors" RELATED [ChEBI] synonym: "protein-serine/threonine kinase inhibitor" RELATED [ChEBI] synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI] is_a: CHEBI:37699 ! protein kinase inhibitor [Term] id: CHEBI:76815 name: EC 2.7.7.* (nucleotidyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*)." [] subset: 3_STAR synonym: "EC 2.7.7.* (nucleotidyltransferase) inhibitors" RELATED [ChEBI] synonym: "inhibitor of nucleotidyltransferases" RELATED [ChEBI] synonym: "inhibitor of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI] synonym: "inhibitors of nucleotidyltransferases" RELATED [ChEBI] synonym: "inhibitors of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI] synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitor" RELATED [ChEBI] synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitors" RELATED [ChEBI] synonym: "nucleotidyltransferase inhibitor" RELATED [ChEBI] synonym: "nucleotidyltransferase inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:76816 name: EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with any enzyme in the EC 2.7.8.* (transferases for other substituted phosphate groups) category." [] subset: 3_STAR synonym: "EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.8.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.8.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:76830 name: EC 5.99.1.* (miscellaneous isomerase) inhibitor namespace: chebi_ontology def: "An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class." [] subset: 3_STAR synonym: "EC 5.99.1.* (miscellaneous isomerase) inhibitors" RELATED [ChEBI] synonym: "EC 5.99.1.* inhibitor" RELATED [ChEBI] synonym: "EC 5.99.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76697 ! EC 5.99.* (other isomerases) inhibitor [Term] id: CHEBI:76834 name: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor namespace: chebi_ontology def: "An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*)." [] subset: 3_STAR synonym: "EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.* inhibitor" RELATED [ChEBI] synonym: "EC 2.5.* inhibitors" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor" RELATED [ChEBI] synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor [Term] id: CHEBI:76837 name: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor namespace: chebi_ontology def: "An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*)." [] subset: 3_STAR synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor" RELATED [ChEBI] synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors" RELATED [ChEBI] synonym: "EC 1.13.11.* inhibitor" RELATED [ChEBI] synonym: "EC 1.13.11.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76740 ! EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor [Term] id: CHEBI:76838 name: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor namespace: chebi_ontology def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*)." [] subset: 3_STAR synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor" RELATED [ChEBI] synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.* inhibitor" RELATED [ChEBI] synonym: "EC 1.14.14.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor [Term] id: CHEBI:76841 name: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor namespace: chebi_ontology def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*)." [] subset: 3_STAR synonym: "EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.* inhibitor" RELATED [ChEBI] synonym: "EC 1.14.13.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor [Term] id: CHEBI:76842 name: vancomycin(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of vancomycin, obtained by deprotonation of the carboxy group and protonation of the two amino functions; major species at pH 7.3." [] subset: 3_STAR synonym: "vancomycin" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation relationship: is_conjugate_acid_of CHEBI:28001 ! vancomycin [Term] id: CHEBI:76853 name: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*)." [] subset: 3_STAR synonym: "EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.2.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.2.3.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76727 ! EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor [Term] id: CHEBI:76857 name: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.3.1.*)." [] subset: 3_STAR synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor [Term] id: CHEBI:76861 name: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.4.3.*)." [] subset: 3_STAR synonym: "EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.4.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.4.3.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76730 ! EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor [Term] id: CHEBI:76863 name: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*)." [] subset: 3_STAR synonym: "EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.5.1.* inhibitor" RELATED [ChEBI] synonym: "EC 1.5.1.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76731 ! EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor [Term] id: CHEBI:76866 name: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*)." [] subset: 3_STAR synonym: "EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.6.5.* inhibitor" RELATED [ChEBI] synonym: "EC 1.6.5.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76733 ! EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor [Term] id: CHEBI:76870 name: EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.9.3.*)." [] subset: 3_STAR synonym: "EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.9.3.* inhibitor" RELATED [ChEBI] synonym: "EC 1.9.3.* inhibitors" RELATED [ChEBI] synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76736 ! EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor [Term] id: CHEBI:76878 name: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor namespace: chebi_ontology def: "An EC 2.3.* (acyltransferase) inhibitor that inhibits the action of any acyltransferase transferring groups other than amino-acyl groups (EC 2.3.1.*)." [] subset: 3_STAR synonym: "acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor" RELATED [ChEBI] synonym: "acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors" RELATED [ChEBI] synonym: "EC 2.3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.3.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76661 ! EC 2.3.* (acyltransferase) inhibitor [Term] id: CHEBI:76881 name: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*)." [] subset: 3_STAR synonym: "EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.1.* inhibitor" RELATED [ChEBI] synonym: "EC 2.7.1.* inhibitors" RELATED [ChEBI] synonym: "phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitor" RELATED [ChEBI] synonym: "phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor [Term] id: CHEBI:76895 name: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor namespace: chebi_ontology def: "An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*)." [] subset: 3_STAR synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor" RELATED [ChEBI] synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.* inhibitor" RELATED [ChEBI] synonym: "EC 3.6.3.* inhibitors" RELATED [ChEBI] is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor [Term] id: CHEBI:76898 name: EC 1.14.14.1 (unspecific monooxygenase) inhibitor namespace: chebi_ontology def: "An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1)." [] subset: 3_STAR synonym: "aryl hydrocarbon hydroxylase inhibitor" RELATED [ChEBI] synonym: "aryl hydrocarbon hydroxylase inhibitors" RELATED [ChEBI] synonym: "aryl-4-monooxygenase inhibitor" RELATED [ChEBI] synonym: "aryl-4-monooxygenase inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.1 (unspecific monooxygenase) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.14.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.14.14.1 inhibitors" RELATED [ChEBI] synonym: "flavoprotein monooxygenase inhibitor" RELATED [ChEBI] synonym: "flavoprotein monooxygenase inhibitors" RELATED [ChEBI] synonym: "flavoprotein-linked monooxygenase inhibitor" RELATED [ChEBI] synonym: "flavoprotein-linked monooxygenase inhibitors" RELATED [ChEBI] synonym: "microsomal monooxygenase inhibitor" RELATED [ChEBI] synonym: "microsomal monooxygenase inhibitors" RELATED [ChEBI] synonym: "microsomal P-450 inhibitor" RELATED [ChEBI] synonym: "microsomal P-450 inhibitors" RELATED [ChEBI] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor" RELATED [ChEBI] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors" RELATED [ChEBI] synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitor" RELATED [ChEBI] synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitors" RELATED [ChEBI] synonym: "unspecific monooxygenase inhibitor" RELATED [ChEBI] synonym: "unspecific monooxygenase inhibitors" RELATED [ChEBI] synonym: "xenobiotic monooxygenase inhibitor" RELATED [ChEBI] synonym: "xenobiotic monooxygenase inhibitors" RELATED [ChEBI] is_a: CHEBI:76838 ! EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor [Term] id: CHEBI:76907 name: EC 4.2.1.* (hydro-lyases) inhibitor namespace: chebi_ontology def: "An EC 4.2.* (C-O lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*)." [] subset: 3_STAR synonym: "EC 4.2.1.* (hydro-lyase) inhibitor" RELATED [ChEBI] synonym: "EC 4.2.1.* (hydro-lyase) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.* (hydro-lyases) inhibitors" RELATED [ChEBI] synonym: "EC 4.2.1.* inhibitor" RELATED [ChEBI] synonym: "EC 4.2.1.* inhibitors" RELATED [ChEBI] synonym: "hydro-lyase (EC 4.2.1.*) inhibitor" RELATED [ChEBI] synonym: "hydro-lyase (EC 4.2.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76712 ! EC 4.2.* (C-O lyase) inhibitor [Term] id: CHEBI:76924 name: plant metabolite namespace: chebi_ontology alt_id: CHEBI:75766 alt_id: CHEBI:76925 def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." [] subset: 3_STAR synonym: "plant metabolites" RELATED [ChEBI] synonym: "plant secondary metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76932 name: pathway inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that interferes with one or more steps in a metabolic pathway." [] subset: 3_STAR synonym: "metabolic pathway inhibitor" RELATED [ChEBI] synonym: "metabolic pathway inhibitors" RELATED [ChEBI] synonym: "pathway inhibitors" RELATED [ChEBI] is_a: CHEBI:23924 ! enzyme inhibitor [Term] id: CHEBI:76946 name: fungal metabolite namespace: chebi_ontology alt_id: CHEBI:75765 alt_id: CHEBI:76947 def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." [] subset: 3_STAR synonym: "fungal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:76964 name: Penicillium metabolite namespace: chebi_ontology alt_id: CHEBI:76205 alt_id: CHEBI:76963 def: "Any fungal metabolite produced during a metabolic reaction in Penicillium." [] subset: 3_STAR synonym: "Penicillium metabolites" RELATED [ChEBI] is_a: CHEBI:76946 ! fungal metabolite [Term] id: CHEBI:76967 name: human xenobiotic metabolite namespace: chebi_ontology def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." [] subset: 3_STAR synonym: "human xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:76206 ! xenobiotic metabolite is_a: CHEBI:77746 ! human metabolite [Term] id: CHEBI:76969 name: bacterial metabolite namespace: chebi_ontology alt_id: CHEBI:75760 alt_id: CHEBI:76970 def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." [] subset: 3_STAR is_a: CHEBI:75787 ! prokaryotic metabolite [Term] id: CHEBI:76971 name: Escherichia coli metabolite namespace: chebi_ontology def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." [] subset: 3_STAR synonym: "E.coli metabolite" RELATED [ChEBI] synonym: "E.coli metabolites" RELATED [ChEBI] synonym: "Escherichia coli metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite [Term] id: CHEBI:77047 name: tylosin(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of tylosin, obtained by protonation of the tertiary amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "tylosin" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:17658 ! tylosin [Term] id: CHEBI:77053 name: closantel namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections." [] subset: 3_STAR synonym: "5'-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2',4'-salicyloxylidide" RELATED [ChemIDplus] synonym: "R 31,520" RELATED [ChemIDplus] synonym: "R 31520" RELATED [ChemIDplus] xref: KEGG:D03567 xref: Patent:BE839481 xref: Patent:US4005218 is_a: CHEBI:60911 ! racemate relationship: BFO:0000051 CHEBI:77056 ! has part (R)-closantel relationship: BFO:0000051 CHEBI:77057 ! has part (S)-closantel relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug [Term] id: CHEBI:77054 name: N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide namespace: chebi_ontology def: "An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively." [] subset: 3_STAR xref: LINCS:LSM-4989 xref: VSDB:1809 is_a: CHEBI:18379 ! nitrile is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33853 ! phenols is_a: CHEBI:37142 ! organoiodine compound is_a: CHEBI:62733 ! aromatic amide is_a: CHEBI:83403 ! monochlorobenzenes [Term] id: CHEBI:77056 name: (R)-closantel namespace: chebi_ontology def: "An N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has R configuration." [] subset: 3_STAR is_a: CHEBI:77054 ! N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide [Term] id: CHEBI:77057 name: (S)-closantel namespace: chebi_ontology def: "An N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has S configuration." [] subset: 3_STAR is_a: CHEBI:77054 ! N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide [Term] id: CHEBI:77102 name: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor namespace: chebi_ontology def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using a quinone or related compound as acceptor (EC 1.3.5.*)." [] subset: 3_STAR synonym: "EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 1.3.5.* inhibitors" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor" RELATED [ChEBI] synonym: "inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor" RELATED [ChEBI] synonym: "inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor" RELATED [ChEBI] synonym: "oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor [Term] id: CHEBI:77194 name: EC 2.7.1.33 (pantothenate kinase) inhibitor namespace: chebi_ontology def: "An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pantothenate kinase (EC 2.7.1.33)." [] subset: 3_STAR synonym: "ATP:(R)-pantothenate 4'-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "ATP:(R)-pantothenate 4'-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "ATP:pantothenate 4'-phosphotransferase inhibitor" RELATED [ChEBI] synonym: "ATP:pantothenate 4'-phosphotransferase inhibitors" RELATED [ChEBI] synonym: "D-pantothenate kinase inhibitor" RELATED [ChEBI] synonym: "D-pantothenate kinase inhibitors" RELATED [ChEBI] synonym: "EC 2.7.1.33 (pantothenate kinase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.1.33 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.1.33 inhibitors" RELATED [ChEBI] synonym: "pantothenate kinase (EC 2.7.1.33) inhibitor" RELATED [ChEBI] synonym: "pantothenate kinase (EC 2.7.1.33) inhibitors" RELATED [ChEBI] synonym: "pantothenate kinase (phosphorylating) inhibitor" RELATED [ChEBI] synonym: "pantothenate kinase (phosphorylating) inhibitors" RELATED [ChEBI] synonym: "pantothenic acid kinase inhibitor" RELATED [ChEBI] synonym: "pantothenic acid kinase inhibitors" RELATED [ChEBI] xref: Wikipedia:Pantothenate_kinase is_a: CHEBI:76881 ! EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor [Term] id: CHEBI:77255 name: EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor namespace: chebi_ontology def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83)." [] subset: 3_STAR synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitor" RELATED [ChEBI] synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.83 inhibitor" RELATED [ChEBI] synonym: "EC 3.4.24.83 inhibitors" RELATED [ChEBI] synonym: "lethal toxin inhibitor" RELATED [ChEBI] synonym: "lethal toxin inhibitors" RELATED [ChEBI] xref: Wikipedia:Anthrax_lethal_factor_endopeptidase is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor [Term] id: CHEBI:77308 name: ethylenebis(dithiocarbamate) namespace: chebi_ontology def: "A member of the class of dithiocarbamate anions resulting from the deprotonation of both of the dithiocarbamic acid moieties of ethylenebis(dithiocarbamic acid). The major species at pH 7.3." [] subset: 3_STAR synonym: "ethylenebis(dithiocarbamic acid)(2-)" RELATED [ChEBI] is_a: CHEBI:84292 ! dithiocarbamate anions relationship: is_conjugate_base_of CHEBI:83986 ! ethylenebis(dithiocarbamic acid) [Term] id: CHEBI:7731 name: ofloxacin namespace: chebi_ontology alt_id: CHEBI:100146 def: "A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication." [] subset: 3_STAR synonym: "(+-)-ofloxacin" RELATED [ChEBI] synonym: "(3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" RELATED [IUPAC] synonym: "DL 8280" RELATED [ChemIDplus] synonym: "DL-8280" RELATED [ChemIDplus] synonym: "HOE 280" RELATED [DrugBank] synonym: "HOE-280" RELATED [DrugBank] synonym: "OFLX" RELATED [KEGG_DRUG] synonym: "ORF 18489" RELATED [ChemIDplus] synonym: "rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid" RELATED [ChEBI] synonym: "rac-ofloxacin" RELATED [ChEBI] synonym: "racemic ofloxacin" RELATED [ChEBI] xref: DrugBank:DB01165 xref: HMDB:HMDB0015296 xref: KEGG:C07321 xref: KEGG:D00453 xref: LINCS:LSM-4370 xref: MetaCyc:CPD-12843 xref: VSDB:1898 xref: Wikipedia:Ofloxacin is_a: CHEBI:60911 ! racemate is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: BFO:0000051 CHEBI:46577 ! has part dextrofloxacin relationship: BFO:0000051 CHEBI:63598 ! has part levofloxacin relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor [Term] id: CHEBI:77315 name: spectinomycin(2+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the secondary amino groups of spectinomycin." [] subset: 3_STAR synonym: "spectinomycin dication" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:146260 ! spectinomycin(1+) relationship: is_conjugate_acid_of CHEBI:9215 ! spectinomycin [Term] id: CHEBI:77318 name: pregnane X receptor agonist namespace: chebi_ontology def: "An agonist that selectively binds to and activates a pregnane X receptor." [] subset: 3_STAR synonym: "pregnane X receptor agonists" RELATED [ChEBI] synonym: "PXR agonist" RELATED [ChEBI] synonym: "PXR agonists" RELATED [ChEBI] xref: Wikipedia:Pregnane_X_receptor is_a: CHEBI:48705 ! agonist [Term] id: CHEBI:77569 name: trovafloxacin(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of trovafloxacin, obtained by protonation of the primary amino group." [] subset: 3_STAR synonym: "trovafloxacin cation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:9763 ! trovafloxacin [Term] id: CHEBI:77615 name: terbinafine(1+) namespace: chebi_ontology def: "An organic cation that is the conjugate acid of terbinafine, obtained by protonation of the amino group; major species at pH 7.3." [] subset: 3_STAR synonym: "terbinafine cation" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:9448 ! terbinafine [Term] id: CHEBI:77718 name: carboxamidinium ion namespace: chebi_ontology def: "Any iminium ion resulting from the protonation of a carboxamidine." [] subset: 3_STAR synonym: "carboxamidinium ions" RELATED [ChEBI] is_a: CHEBI:35286 ! iminium ion [Term] id: CHEBI:77733 name: 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile namespace: chebi_ontology def: "A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group." [] subset: 3_STAR xref: KEGG:C07188 xref: KEGG:D02356 xref: LINCS:LSM-1298 is_a: CHEBI:18379 ! nitrile is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:46774 ! polyether is_a: CHEBI:50996 ! tertiary amino compound [Term] id: CHEBI:77734 name: dexverapamil namespace: chebi_ontology def: "A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil." [] subset: 3_STAR synonym: "(+)-(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(+)-(R)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile" RELATED [ChemIDplus] synonym: "(+)-(R)-verapamil" RELATED [ChEBI] synonym: "(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(+)-3-(3,4-dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile" RELATED [ChEBI] synonym: "(+)-verapamil" RELATED [ChEBI] synonym: "(2R)-(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(R)-(+)-verapamil" RELATED [ChEBI] synonym: "(R)-verapamil" RELATED [ChEBI] is_a: CHEBI:77733 ! 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile relationship: is_conjugate_base_of CHEBI:77737 ! dexverapamil(1+) relationship: is_enantiomer_of CHEBI:77736 ! (S)-verapamil relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor [Term] id: CHEBI:77736 name: (S)-verapamil namespace: chebi_ontology def: "A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has S configuration." [] subset: 3_STAR synonym: "(-)-(S)-verapamil" RELATED [ChEBI] synonym: "(-)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [ChEBI] synonym: "(-)-verapamil" RELATED [ChEBI] synonym: "(S)-(-)-verapamil" RELATED [ChEBI] is_a: CHEBI:77733 ! 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile relationship: is_conjugate_base_of CHEBI:77738 ! (S)-verapamil(1+) relationship: is_enantiomer_of CHEBI:77734 ! dexverapamil [Term] id: CHEBI:77737 name: dexverapamil(1+) namespace: chebi_ontology def: "An ammonium ion resulting from the protonation of the tertiary amino group of dexverapamil." [] subset: 3_STAR synonym: "(R)-verapamil(1+)" RELATED [ChEBI] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:77734 ! dexverapamil relationship: is_enantiomer_of CHEBI:77738 ! (S)-verapamil(1+) [Term] id: CHEBI:77738 name: (S)-verapamil(1+) namespace: chebi_ontology def: "An ammonium ion resulting from the protonation of the tertiary amino group of (S)-verapamil." [] subset: 3_STAR synonym: "(S)-verapamil(1+)" EXACT [ChEBI] is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:77736 ! (S)-verapamil relationship: is_enantiomer_of CHEBI:77737 ! dexverapamil(1+) [Term] id: CHEBI:77745 name: EC 3.4.24.18 (meprin A) inhibitor namespace: chebi_ontology def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that inhibits the action of meprin A (EC 3.4.24.18)." [] subset: 3_STAR synonym: "EC 3.4.24.18 (meprin A) inhibitors" RELATED [ChEBI] synonym: "EC 3.4.24.18 inhibitor" RELATED [ChEBI] synonym: "EC 3.4.24.18 inhibitors" RELATED [ChEBI] synonym: "endopeptidase-2 inhibitor" RELATED [ChEBI] synonym: "endopeptidase-2 inhibitors" RELATED [ChEBI] synonym: "meprin A (EC 3.4.24.18) inhibitor" RELATED [ChEBI] synonym: "meprin A (EC 3.4.24.18) inhibitors" RELATED [ChEBI] synonym: "meprin A inhibitor" RELATED [ChEBI] synonym: "meprin A inhibitors" RELATED [ChEBI] synonym: "meprin inhibitor" RELATED [ChEBI] synonym: "meprin inhibitors" RELATED [ChEBI] synonym: "meprin-a inhibitor" RELATED [ChEBI] synonym: "meprin-a inhibitors" RELATED [ChEBI] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitor" RELATED [ChEBI] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitors" RELATED [ChEBI] synonym: "PABA-peptide hydrolase inhibitor" RELATED [ChEBI] synonym: "PABA-peptide hydrolase inhibitors" RELATED [ChEBI] synonym: "PPH inhibitor" RELATED [ChEBI] synonym: "PPH inhibitors" RELATED [ChEBI] xref: Wikipedia:Meprin_A is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor [Term] id: CHEBI:77746 name: human metabolite namespace: chebi_ontology alt_id: CHEBI:75770 alt_id: CHEBI:77123 def: "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." [] subset: 3_STAR synonym: "H. sapiens metabolite" RELATED [ChEBI] synonym: "H. sapiens metabolites" RELATED [ChEBI] synonym: "Homo sapiens metabolite" RELATED [ChEBI] synonym: "Homo sapiens metabolites" RELATED [ChEBI] is_a: CHEBI:75768 ! mammalian metabolite [Term] id: CHEBI:77747 name: EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor namespace: chebi_ontology def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of phospholipid-translocating ATPase (EC 3.6.3.1)." [] subset: 3_STAR synonym: "aminophospholipid-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "aminophospholipid-transporting ATPase inhibitors" RELATED [ChEBI] synonym: "ATP phosphohydrolase (phospholipid-flipping) inhibitor" RELATED [ChEBI] synonym: "ATP phosphohydrolase (phospholipid-flipping) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.1 inhibitor" RELATED [ChEBI] synonym: "EC 3.6.3.1 inhibitors" RELATED [ChEBI] synonym: "flippase inhibitor" RELATED [ChEBI] synonym: "flippase inhibitors" RELATED [ChEBI] synonym: "magnesium-ATPase inhibitor" RELATED [ChEBI] synonym: "magnesium-ATPase inhibitors" RELATED [ChEBI] synonym: "Mg(2)(+)-ATPase inhibitor" RELATED [ChEBI] synonym: "Mg(2)(+)-ATPase inhibitors" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase (EC 3.6.3.1) inhibitor" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase (EC 3.6.3.1) inhibitors" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase inhibitor" RELATED [ChEBI] synonym: "phospholipid-translocating ATPase inhibitors" RELATED [ChEBI] synonym: "phospholipid-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "phospholipid-transporting ATPase inhibitors" RELATED [ChEBI] xref: Wikipedia:Phospholipid-translocating_ATPase is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor [Term] id: CHEBI:77748 name: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor namespace: chebi_ontology def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44)." [] subset: 3_STAR synonym: "ATP phosphohydrolase (steroid-exporting) inhibitor" RELATED [ChEBI] synonym: "ATP phosphohydrolase (steroid-exporting) inhibitors" RELATED [ChEBI] synonym: "ATP phosphohydrolase (xenobiotic-exporting) inhibitor" RELATED [ChEBI] synonym: "ATP phosphohydrolase (xenobiotic-exporting) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors" RELATED [ChEBI] synonym: "EC 3.6.3.44 inhibitor" RELATED [ChEBI] synonym: "EC 3.6.3.44 inhibitors" RELATED [ChEBI] synonym: "MDR protein inhibitor" RELATED [ChEBI] synonym: "MDR protein inhibitors" RELATED [ChEBI] synonym: "multidrug-resistance protein inhibitor" RELATED [ChEBI] synonym: "multidrug-resistance protein inhibitors" RELATED [ChEBI] synonym: "P-glycoprotein inhibitor" RELATED [ChEBI] synonym: "P-glycoprotein inhibitors" RELATED [ChEBI] synonym: "PDR protein inhibitor" RELATED [ChEBI] synonym: "PDR protein inhibitors" RELATED [ChEBI] synonym: "pleiotropic-drug-resistance protein inhibitor" RELATED [ChEBI] synonym: "pleiotropic-drug-resistance protein inhibitors" RELATED [ChEBI] synonym: "steroid-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "steroid-transporting ATPase inhibitors" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase inhibitor" RELATED [ChEBI] synonym: "xenobiotic-transporting ATPase inhibitors" RELATED [ChEBI] xref: Wikipedia:Xenobiotic-transporting_ATPase is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor [Term] id: CHEBI:77853 name: persistent organic pollutant namespace: chebi_ontology def: "Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains." [] subset: 3_STAR synonym: "persistent organic pollutants" RELATED [ChEBI] synonym: "POP" RELATED [ChEBI] synonym: "POPs" RELATED [ChEBI] xref: Wikipedia:Persistant_organic_pollutant is_a: CHEBI:78298 ! environmental contaminant [Term] id: CHEBI:77884 name: EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor namespace: chebi_ontology def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14alpha-demethylase)." [] subset: 3_STAR synonym: "cytochrome P450 51 inhibitor" RELATED [ChEBI] synonym: "cytochrome P450 51 inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.70 inhibitor" RELATED [ChEBI] synonym: "EC 1.14.13.70 inhibitors" RELATED [ChEBI] synonym: "lanosterol 14-demethylase inhibitor" RELATED [ChEBI] synonym: "lanosterol 14-demethylase inhibitors" RELATED [ChEBI] synonym: "lanosterol 14alpha-demethylase inhibitor" RELATED [ChEBI] synonym: "lanosterol 14alpha-demethylase inhibitors" RELATED [ChEBI] synonym: "obtusufoliol 14-demethylase inhibitor" RELATED [ChEBI] synonym: "obtusufoliol 14-demethylase inhibitors" RELATED [ChEBI] synonym: "sterol 14-demethylase inhibitor" RELATED [ChEBI] synonym: "sterol 14-demethylase inhibitors" RELATED [ChEBI] synonym: "sterol 14alpha-demethylase inhibitor" RELATED [ChEBI] synonym: "sterol 14alpha-demethylase inhibitors" RELATED [ChEBI] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitor" RELATED [ChEBI] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitors" RELATED [ChEBI] xref: Wikipedia:Sterol_14-demethylase is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor is_a: CHEBI:83734 ! sterol demethylation inhibitor [Term] id: CHEBI:77906 name: minocycline zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of minocycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "minocycline" RELATED [UniProt] is_a: CHEBI:144644 ! a tetracycline zwitterion is_a: CHEBI:27369 ! zwitterion relationship: is_conjugate_acid_of CHEBI:71337 ! minocycline(1-) relationship: is_tautomer_of CHEBI:50694 ! minocycline [Term] id: CHEBI:77932 name: tetracycline zwitterion namespace: chebi_ontology def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of tetracycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "tetracycline" RELATED [UniProt] is_a: CHEBI:144644 ! a tetracycline zwitterion is_a: CHEBI:27369 ! zwitterion relationship: is_conjugate_acid_of CHEBI:71392 ! tetracycline(1-) relationship: is_tautomer_of CHEBI:27902 ! tetracycline relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor [Term] id: CHEBI:77941 name: EC 3.5.1.4 (amidase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." [] subset: 3_STAR synonym: "acylamidase inhibitor" RELATED [ChEBI] synonym: "acylamidase inhibitors" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI] synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI] synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI] synonym: "amidase inhibitor" RELATED [ChEBI] synonym: "amidase inhibitors" RELATED [ChEBI] synonym: "amidohydrolase inhibitor" RELATED [ChEBI] synonym: "amidohydrolase inhibitors" RELATED [ChEBI] synonym: "deaminase inhibitor" RELATED [ChEBI] synonym: "deaminase inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI] synonym: "fatty acylamidase inhibitor" RELATED [ChEBI] synonym: "fatty acylamidase inhibitors" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI] synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Amidase is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:77981 name: vancomycin aglycone(1-) namespace: chebi_ontology def: "A peptide anion that is the conjugate base of vancomycin aglycone and the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] subset: 3_STAR synonym: "vancomycin aglycone" RELATED [UniProt] is_a: CHEBI:50525 ! phenolate anion is_a: CHEBI:60334 ! peptide anion relationship: is_conjugate_base_of CHEBI:47724 ! vancomycin aglycone relationship: is_conjugate_base_of CHEBI:75954 ! vancomycin aglycone zwitterion [Term] id: CHEBI:7809 name: oxacillin namespace: chebi_ontology def: "A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta." [] subset: 3_STAR synonym: "(2S,5R,6R)-3,3-dimethyl-6-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "(5-methyl-3-phenyl-4-isoxazolyl)penicillin" RELATED [ChemIDplus] synonym: "5-methyl-3-phenyl-4-isoxazolyl-penicillin" RELATED [ChemIDplus] synonym: "6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanic acid" RELATED [ChEBI] synonym: "Oxacillin" EXACT [KEGG_COMPOUND] synonym: "oxazocillin" RELATED [ChemIDplus] xref: DrugBank:DB00713 xref: HMDB:HMDB0014851 xref: KEGG:C07334 xref: KEGG:D08307 xref: LINCS:LSM-6005 xref: Patent:US2996501 xref: Wikipedia:Oxacillin is_a: CHEBI:17334 ! penicillin relationship: is_conjugate_acid_of CHEBI:52132 ! oxacillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:78128 name: fatty acid anion 24:0 namespace: chebi_ontology def: "Any saturated fatty acid anion containing 24 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." [] subset: 3_STAR synonym: "fatty acid 24:0" RELATED [UniProt] is_a: CHEBI:58953 ! saturated fatty acid anion [Term] id: CHEBI:78295 name: food component namespace: chebi_ontology def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." [] subset: 3_STAR synonym: "dietary component" RELATED [ChEBI] synonym: "dietary components" RELATED [ChEBI] synonym: "food components" RELATED [ChEBI] is_a: CHEBI:52211 ! physiological role [Term] id: CHEBI:78298 name: environmental contaminant namespace: chebi_ontology def: "Any minor or unwanted substance introduced into the environment that can have undesired effects." [] subset: 3_STAR synonym: "environmental contaminants" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:78379 name: EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor namespace: chebi_ontology def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7)." [] subset: 3_STAR synonym: "EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitors" RELATED [ChEBI] synonym: "EC 2.5.1.7 inhibitor" RELATED [ChEBI] synonym: "EC 2.5.1.7 inhibitors" RELATED [ChEBI] synonym: "enoylpyruvate transferase inhibitor" RELATED [ChEBI] synonym: "enoylpyruvate transferase inhibitors" RELATED [ChEBI] synonym: "MurA transferase inhibitor" RELATED [ChEBI] synonym: "MurA transferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitors" RELATED [ChEBI] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitor" RELATED [ChEBI] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitors" RELATED [ChEBI] synonym: "pyruvate-UDP-acetylglucosamine transferase inhibitor" RELATED [ChEBI] synonym: "pyruvate-UDP-acetylglucosamine transferase inhibitors" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitor" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitors" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitor" RELATED [ChEBI] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitors" RELATED [ChEBI] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitor" RELATED [ChEBI] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitors" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitor" RELATED [ChEBI] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitors" RELATED [ChEBI] xref: Wikipedia:UDP-N-acetylglucosamine_1-carboxyvinyltransferase is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor [Term] id: CHEBI:78433 name: refrigerant namespace: chebi_ontology def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." [] subset: 3_STAR synonym: "refrigerants" RELATED [ChEBI] xref: Wikipedia:Refrigerant is_a: CHEBI:33232 ! application [Term] id: CHEBI:78608 name: alpha-amino-acid zwitterion namespace: chebi_ontology alt_id: CHEBI:83409 def: "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." [] subset: 3_STAR synonym: "alpha-amino acid zwitterion" RELATED [ChEBI] synonym: "alpha-amino acid zwitterions" RELATED [ChEBI] synonym: "alpha-amino-acid zwitterions" RELATED [ChEBI] synonym: "an alpha-amino acid" RELATED [UniProt] is_a: CHEBI:35238 ! amino-acid zwitterion relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid [Term] id: CHEBI:78616 name: carbohydrates and carbohydrate derivatives namespace: chebi_ontology def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." [] subset: 3_STAR synonym: "carbohydrates and derivatives" RELATED [ChEBI] synonym: "carbohydrates and their derivatives" RELATED [ChEBI] is_a: CHEBI:36963 ! organooxygen compound [Term] id: CHEBI:78675 name: fundamental metabolite namespace: chebi_ontology def: "Any metabolite produced by all living cells." [] subset: 3_STAR synonym: "essential metabolite" RELATED [ChEBI] synonym: "essential metabolites" RELATED [ChEBI] synonym: "fundamental metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite [Term] id: CHEBI:78692 name: 1-[biphenyl-4-yl(phenyl)methyl]imidazole namespace: chebi_ontology def: "A member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1." [] subset: 3_STAR xref: LINCS:LSM-5184 is_a: CHEBI:22888 ! biphenyls is_a: CHEBI:24780 ! imidazoles [Term] id: CHEBI:78693 name: (R)-bifonazole namespace: chebi_ontology def: "A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the R-enantiomer of bifonazole." [] subset: 3_STAR synonym: "(-)-bifonazole" RELATED [ChEBI] synonym: "(R)-(-)-bifonazole" RELATED [ChEBI] is_a: CHEBI:78692 ! 1-[biphenyl-4-yl(phenyl)methyl]imidazole relationship: is_enantiomer_of CHEBI:78694 ! (S)-bifonazole [Term] id: CHEBI:78694 name: (S)-bifonazole namespace: chebi_ontology def: "A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the S-enantiomer of bifonazole." [] subset: 3_STAR synonym: "(+)-bifonazole" RELATED [ChEBI] synonym: "(S)-(+)-bifonazole" RELATED [ChEBI] is_a: CHEBI:78692 ! 1-[biphenyl-4-yl(phenyl)methyl]imidazole relationship: is_enantiomer_of CHEBI:78693 ! (R)-bifonazole [Term] id: CHEBI:78696 name: cercosporamide namespace: chebi_ontology def: "A member of the class of dibenzofurans that is a potent broad spectrum antifungal agent isolated from the fungus Cercosporidium henningsii." [] subset: 3_STAR xref: Patent:CN101292039 xref: Patent:EP1914313 xref: Patent:JP2008214336 xref: Patent:KR20080033345 xref: Patent:US2010152467 xref: Patent:WO2007018194 is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:38922 ! dibenzofurans is_a: CHEBI:51867 ! methyl ketone relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:38231 ! has role phytotoxin relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite relationship: RO:0000087 CHEBI:79091 ! has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor [Term] id: CHEBI:78787 name: dithiocarbamic acids namespace: chebi_ontology def: "Any organic acid in which both oxygens of a carbamic acid have been replaced by sulfur." [] subset: 3_STAR synonym: "dithiocarbamic acid" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:50492 ! thiocarbonyl compound is_a: CHEBI:64709 ! organic acid relationship: is_conjugate_acid_of CHEBI:84292 ! dithiocarbamate anions [Term] id: CHEBI:78840 name: olefinic compound namespace: chebi_ontology def: "Any organic molecular entity that contains at least one C=C bond." [] subset: 3_STAR synonym: "olefinic compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:79020 name: alpha,beta-unsaturated monocarboxylic acid namespace: chebi_ontology def: "A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C#C bond." [] subset: 3_STAR synonym: "2,3-unsaturated monocarboxylic acid" RELATED [ChEBI] synonym: "2,3-unsaturated monocarboxylic acids" RELATED [ChEBI] synonym: "alpha,beta-unsaturated monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:25384 ! monocarboxylic acid [Term] id: CHEBI:79091 name: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor namespace: chebi_ontology alt_id: CHEBI:75997 def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24)." [] subset: 3_STAR synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitor" RELATED [ChEBI] synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitors" RELATED [ChEBI] synonym: "c-Jun N-terminal kinase inhibitor" RELATED [ChEBI] synonym: "c-Jun N-terminal kinase inhibitors" RELATED [ChEBI] synonym: "Dp38 inhibitor" RELATED [ChEBI] synonym: "Dp38 inhibitors" RELATED [ChEBI] synonym: "EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors" RELATED [ChEBI] synonym: "EC 2.7.11.24 inhibitor" RELATED [ChEBI] synonym: "EC 2.7.11.24 inhibitors" RELATED [ChEBI] synonym: "ERK inhibitor" RELATED [ChEBI] synonym: "ERK inhibitors" RELATED [ChEBI] synonym: "ERK1 inhibitor" RELATED [ChEBI] synonym: "ERK1 inhibitors" RELATED [ChEBI] synonym: "ERK2 inhibitor" RELATED [ChEBI] synonym: "ERK2 inhibitors" RELATED [ChEBI] synonym: "extracellular signal-regulated kinase inhibitor" RELATED [ChEBI] synonym: "extracellular signal-regulated kinase inhibitors" RELATED [ChEBI] synonym: "JNK inhibitor" RELATED [ChEBI] synonym: "JNK inhibitors" RELATED [ChEBI] synonym: "JNK3alpha1 inhibitor" RELATED [ChEBI] synonym: "JNK3alpha1 inhibitors" RELATED [ChEBI] synonym: "LeMPK3 inhibitor" RELATED [ChEBI] synonym: "LeMPK3 inhibitors" RELATED [ChEBI] synonym: "MAP kinase inhibitor" RELATED [ChEBI] synonym: "MAP kinase inhibitors" RELATED [ChEBI] synonym: "MAP-2 kinase inhibitor" RELATED [ChEBI] synonym: "MAP-2 kinase inhibitors" RELATED [ChEBI] synonym: "MAPK inhibitor" RELATED [ChEBI] synonym: "MAPK inhibitors" RELATED [ChEBI] synonym: "MBP kinase I inhibitor" RELATED [ChEBI] synonym: "MBP kinase I inhibitors" RELATED [ChEBI] synonym: "MBP kinase II inhibitor" RELATED [ChEBI] synonym: "MBP kinase II inhibitors" RELATED [ChEBI] synonym: "MEK inhibitor" RELATED [ChEBI] synonym: "MEK inhibitors" RELATED [ChEBI] synonym: "microtubule-associated protein 2 kinase inhibitor" RELATED [ChEBI] synonym: "microtubule-associated protein 2 kinase inhibitors" RELATED [ChEBI] synonym: "microtubule-associated protein kinase inhibitor" RELATED [ChEBI] synonym: "microtubule-associated protein kinase inhibitors" RELATED [ChEBI] synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitor" RELATED [ChEBI] synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitors" RELATED [ChEBI] synonym: "mitogen-activated protein kinase inhibitor" RELATED [ChEBI] synonym: "mitogen-activated protein kinase inhibitors" RELATED [ChEBI] synonym: "myelin basic protein kinase inhibitor" RELATED [ChEBI] synonym: "myelin basic protein kinase inhibitors" RELATED [ChEBI] synonym: "p38-2 inhibitor" RELATED [ChEBI] synonym: "p38-2 inhibitors" RELATED [ChEBI] synonym: "p38delta inhibitor" RELATED [ChEBI] synonym: "p38delta inhibitors" RELATED [ChEBI] synonym: "p42 mitogen-activated protein kinase inhibitor" RELATED [ChEBI] synonym: "p42 mitogen-activated protein kinase inhibitors" RELATED [ChEBI] synonym: "p42(mapk) inhibitor" RELATED [ChEBI] synonym: "p42(mapk) inhibitors" RELATED [ChEBI] synonym: "p44mpk inhibitor" RELATED [ChEBI] synonym: "p44mpk inhibitors" RELATED [ChEBI] synonym: "PMK-1 inhibitor" RELATED [ChEBI] synonym: "PMK-1 inhibitors" RELATED [ChEBI] synonym: "PMK-2 inhibitor" RELATED [ChEBI] synonym: "PMK-2 inhibitors" RELATED [ChEBI] synonym: "PMK-3 inhibitor" RELATED [ChEBI] synonym: "PMK-3 inhibitors" RELATED [ChEBI] synonym: "pp42 inhibitor" RELATED [ChEBI] synonym: "pp42 inhibitors" RELATED [ChEBI] synonym: "pp44(mapk) inhibitor" RELATED [ChEBI] synonym: "pp44(mapk) inhibitors" RELATED [ChEBI] synonym: "SAPK inhibitor" RELATED [ChEBI] synonym: "SAPK inhibitors" RELATED [ChEBI] synonym: "STK26 inhibitor" RELATED [ChEBI] synonym: "STK26 inhibitors" RELATED [ChEBI] synonym: "stress-activated protein kinase inhibitor" RELATED [ChEBI] synonym: "stress-activated protein kinase inhibitors" RELATED [ChEBI] xref: Wikipedia:MEK_inhibitor xref: Wikipedia:Mitogen-activated_protein_kinase is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor [Term] id: CHEBI:79092 name: EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor namespace: chebi_ontology def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any such enzyme using H2O2 as acceptor and incorporating one oxygen atom of the H2O2 into the product (EC 1.11.2.*)." [] subset: 3_STAR synonym: "EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.2.* inhibitor" RELATED [ChEBI] synonym: "EC 1.11.2.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor [Term] id: CHEBI:79093 name: EC 1.11.2.2 (myeloperoxidase) inhibitor namespace: chebi_ontology def: "An EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor that interferes with the action of myeloperoxidase (EC 1.11.2.2)." [] subset: 3_STAR synonym: "chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitor" RELATED [ChEBI] synonym: "chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.2.2 (myeloperoxidase) inhibitors" RELATED [ChEBI] synonym: "EC 1.11.2.2 inhibitor" RELATED [ChEBI] synonym: "EC 1.11.2.2 inhibitors" RELATED [ChEBI] synonym: "MPO inhibitor" RELATED [ChEBI] synonym: "MPO inhibitors" RELATED [ChEBI] synonym: "myeloperoxidase (EC 1.11.2.2) inhibitor" RELATED [ChEBI] synonym: "myeloperoxidase (EC 1.11.2.2) inhibitors" RELATED [ChEBI] synonym: "myeloperoxidase inhibitor" RELATED [ChEBI] synonym: "myeloperoxidase inhibitors" RELATED [ChEBI] synonym: "verdoperoxidase inhibitor" RELATED [ChEBI] synonym: "verdoperoxidase inhibitors" RELATED [ChEBI] xref: Wikipedia:Myeloperoxidase is_a: CHEBI:79092 ! EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor [Term] id: CHEBI:79314 name: flame retardant namespace: chebi_ontology def: "Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire." [] subset: 3_STAR synonym: "flame retardants" RELATED [ChEBI] xref: Wikipedia:Flame_retardant is_a: CHEBI:33232 ! application [Term] id: CHEBI:7934 name: paromomycin namespace: chebi_ontology alt_id: CHEBI:44703 def: "An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis." [] subset: 3_STAR synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside" RELATED [PDBeChem] synonym: "Aminosidin" RELATED [KEGG_COMPOUND] synonym: "aminosidine" RELATED [ChemIDplus] synonym: "Catenulin" RELATED [KEGG_COMPOUND] synonym: "crestomycin" RELATED [ChemIDplus] synonym: "estomycin" RELATED [ChemIDplus] synonym: "Hydroxymycin" RELATED [KEGG_COMPOUND] synonym: "hydroxymycin" RELATED [ChemIDplus] synonym: "Monomycin A" RELATED [KEGG_COMPOUND] synonym: "Neomycin E" RELATED [KEGG_COMPOUND] synonym: "neomycin E" RELATED [ChemIDplus] synonym: "PAROMOMYCIN" EXACT [PDBeChem] synonym: "Paromomycin" EXACT [KEGG_COMPOUND] synonym: "Paromomycin I" RELATED [KEGG_COMPOUND] synonym: "paucimycin" RELATED [ChemIDplus] synonym: "paucimycinum" RELATED [ChemIDplus] synonym: "R 400" RELATED [ChemIDplus] synonym: "R-400" RELATED [ChEBI] synonym: "Zygomycin A1" RELATED [KEGG_COMPOUND] xref: DrugBank:DB01421 xref: KEGG:C00832 xref: KEGG:D07467 xref: Patent:US2895876 xref: Patent:US2916485 xref: PDBeChem:PAR is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic relationship: has_functional_parent CHEBI:27955 ! streptamine relationship: is_conjugate_base_of CHEBI:233202 ! paromomycin(5+) relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:79387 name: trivalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of three." [] subset: 3_STAR synonym: "trivalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:79388 name: divalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of two." [] subset: 3_STAR synonym: "divalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:79389 name: monovalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of one." [] subset: 3_STAR synonym: "monovalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion [Term] id: CHEBI:81758 name: cyproconazole namespace: chebi_ontology def: "A diastereoisomeric mixture composed of the enantiomeric pair (2R,3S)- and (2S,3R)-cyproconazole in ratio 1:1 with the enantiomeric pair (2R,3R)- and (2S,3S)-cyproconazole. A broad spectrum fungicide, it is used on cereals and other field crops used to control Septoria, rust, powdery mildew and other diseases." [] subset: 3_STAR synonym: "alpha-(4-chlorophenyl)-alpha-(1-cyclopropylethyl)-1N-1,2,4-triazole-1-ethanol" RELATED [Alan_Wood's_Pesticides] xref: KEGG:C18456 is_a: CHEBI:60915 ! diastereoisomeric mixture is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: BFO:0000051 CHEBI:83749 ! has part (2R,3S)-cyproconazole relationship: BFO:0000051 CHEBI:83750 ! has part (2S,3S)-cyproconazole relationship: BFO:0000051 CHEBI:83752 ! has part (2S,3R)-cyproconazole relationship: BFO:0000051 CHEBI:83753 ! has part (2R,3R)-cyproconazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81760 name: difenoconazole namespace: chebi_ontology def: "A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms." [] subset: 3_STAR xref: KEGG:C18459 xref: PPDB:230 is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81763 name: fludioxonil namespace: chebi_ontology def: "A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria." [] subset: 3_STAR xref: KEGG:C18462 xref: PPDB:330 is_a: CHEBI:18379 ! nitrile is_a: CHEBI:26455 ! pyrroles is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38298 ! benzodioxoles relationship: RO:0000087 CHEBI:35497 ! has role androgen antagonist relationship: RO:0000087 CHEBI:63951 ! has role estrogen receptor agonist relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81781 name: tebuconazole namespace: chebi_ontology alt_id: CHEBI:83566 def: "A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops." [] subset: 3_STAR synonym: "(RS)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" RELATED [Alan_Wood's_Pesticides] synonym: "Ethyltrianol" RELATED [ChemIDplus] synonym: "Fenetrazole" RELATED [ChemIDplus] synonym: "Terbuconazole" RELATED [ChemIDplus] xref: KEGG:C18489 xref: Wikipedia:Tebuconazole is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: BFO:0000051 CHEBI:83780 ! has part (S)-tebuconazole relationship: BFO:0000051 CHEBI:83781 ! has part (R)-tebuconazole relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81783 name: tricyclazole namespace: chebi_ontology def: "A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union." [] subset: 3_STAR synonym: "5-methyl-1,2,4-triazolo[3,4-b]benzothiazole" RELATED [Alan_Wood's_Pesticides] synonym: "5-methyl-striazolo-[3,4-b]benzothiazole" RELATED [ChEBI] xref: HMDB:HMDB0031809 xref: KEGG:C18492 xref: PDBeChem:BEA xref: PPDB:660 is_a: CHEBI:48908 ! triazolobenzothiazole relationship: is_conjugate_base_of CHEBI:41032 ! 5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium relationship: RO:0000087 CHEBI:64933 ! has role melanin synthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81822 name: boscalid namespace: chebi_ontology def: "A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals." [] subset: 3_STAR synonym: "2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide" RELATED [Alan_Wood's_Pesticides] synonym: "2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide" RELATED [Alan_Wood's_Pesticides] xref: KEGG:C18547 xref: PPDB:86 is_a: CHEBI:22888 ! biphenyls is_a: CHEBI:25529 ! pyridinecarboxamide is_a: CHEBI:83403 ! monochlorobenzenes is_a: CHEBI:87015 ! anilide fungicide relationship: has_functional_parent CHEBI:15940 ! nicotinic acid relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:83072 ! has role EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81853 name: fenhexamid namespace: chebi_ontology def: "An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol." [] subset: 3_STAR synonym: "2',3'-dichloro-4'-hydroxy-1-methylcyclohexanecarboxanilide" RELATED [ChEBI] synonym: "fenhexamide" RELATED [ChEBI] synonym: "KBR 2738" RELATED [ChemIDplus] synonym: "KBR-2738" RELATED [ChEBI] synonym: "N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexane-1-carboxamide" RELATED [Alan_Wood's_Pesticides] xref: KEGG:C18593 xref: Patent:EP339418 xref: Patent:US5059623 xref: PPDB:298 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33853 ! phenols is_a: CHEBI:62733 ! aromatic amide is_a: CHEBI:87015 ! anilide fungicide relationship: RO:0000087 CHEBI:83316 ! has role EC 1.14.13.72 (methylsterol monooxygenase) inhibitor relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81913 name: diniconazole namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts." [] subset: 3_STAR synonym: "(+-)-diniconazole" RELATED [ChEBI] synonym: "(betaE)-beta-[(2,4-dichlorophenyl)methylene]-alpha-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol" RELATED [Alan_Wood's_Pesticides] synonym: "(E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol" RELATED [ChemIDplus] synonym: "(RS)-diniconazole" RELATED [ChEBI] synonym: "1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol" RELATED [NIST_Chemistry_WebBook] synonym: "rac-diniconazole" RELATED [ChEBI] synonym: "racemic diniconazole" RELATED [ChEBI] xref: KEGG:C18720 xref: PPDB:247 is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: BFO:0000051 CHEBI:83906 ! has part (S)-diniconazole relationship: BFO:0000051 CHEBI:83911 ! has part diniconazole-M relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81917 name: fenpropidin namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-fenpropidin. A systemic fungicide, it is used for the control of foliar diseases in cereals and sugar beet." [] subset: 3_STAR synonym: "(+-)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" RELATED [ChEBI] synonym: "(RS)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" RELATED [ChEBI] synonym: "fenpropidine" RELATED [ChemIDplus] synonym: "Ro 12-3049" RELATED [ChemIDplus] synonym: "Ro-12-3049" RELATED [NIST_Chemistry_WebBook] xref: KEGG:C18726 xref: PPDB:307 is_a: CHEBI:60911 ! racemate relationship: BFO:0000051 CHEBI:83293 ! has part (R)-fenpropidin relationship: BFO:0000051 CHEBI:83294 ! has part (S)-fenpropidin relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:83319 ! has role EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:81923 name: flutriafol namespace: chebi_ontology def: "A racemate comprising an equimolar mixture of (R)- and (S)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops." [] subset: 3_STAR synonym: "(+-)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol" RELATED [ChEBI] synonym: "(+-)-flutriafol" RELATED [ChEBI] synonym: "(RS)-2,4'-difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol" RELATED [Alan_Wood's_Pesticides] synonym: "alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol" RELATED [Alan_Wood's_Pesticides] synonym: "PP 450" RELATED [NIST_Chemistry_WebBook] synonym: "R 152450" RELATED [NIST_Chemistry_WebBook] synonym: "rac flutriafol" RELATED [ChEBI] synonym: "rac-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol" RELATED [Alan_Wood's_Pesticides] xref: KEGG:C18734 xref: Patent:EP15756 is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: BFO:0000051 CHEBI:83708 ! has part (R)-flutriafol relationship: BFO:0000051 CHEBI:83709 ! has part (S)-flutriafol relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:8232 name: piperacillin namespace: chebi_ontology alt_id: CHEBI:472443 alt_id: CHEBI:475140 alt_id: CHEBI:505944 def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "Piperacillin" EXACT [KEGG_COMPOUND] synonym: "Piperacillin anhydrous" RELATED [KEGG_COMPOUND] xref: DrugBank:DB00319 xref: KEGG:C14034 xref: KEGG:D08380 xref: LINCS:LSM-5924 xref: Patent:DE2519400 xref: Patent:US4087424 xref: Wikipedia:Piperacillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:52433 ! piperacillin(1-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:8269 name: Pleuromutilin namespace: chebi_ontology subset: 2_STAR synonym: "Pleuromutilin" EXACT [KEGG_COMPOUND] xref: KEGG:C09169 xref: KNApSAcK:C00003473 is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:38032 ! carbotricyclic compound is_a: CHEBI:3992 ! cyclic ketone [Term] id: CHEBI:8273 name: plumbagin namespace: chebi_ontology def: "A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively." [] subset: 3_STAR synonym: "2-methyl-5-hydroxy-1,4-naphthoquinone" RELATED [ChemIDplus] synonym: "2-methyljuglone" RELATED [ChEBI] synonym: "5-hydroxy-2-methyl-1,4-naphthalenedione" RELATED [ChemIDplus] synonym: "5-hydroxy-2-methyl-1,4-naphthoquinone" RELATED [ChEBI] synonym: "plumbaein" RELATED [ChEBI] synonym: "Plumbagin" EXACT [KEGG_COMPOUND] synonym: "plumbagine" RELATED [MetaCyc] synonym: "plumbagone" RELATED [ChEBI] xref: KEGG:C10387 xref: KNApSAcK:C00002852 xref: LINCS:LSM-37061 xref: MetaCyc:CPD-4461 xref: Patent:CN1473468 xref: Patent:IN183682 xref: Patent:IN191797 xref: PDBeChem:90R xref: Wikipedia:Plumbagin is_a: CHEBI:132157 ! hydroxy-1,4-naphthoquinone is_a: CHEBI:33853 ! phenols relationship: RO:0000087 CHEBI:25212 ! has role metabolite relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:50249 ! has role anticoagulant relationship: RO:0000087 CHEBI:50847 ! has role immunological adjuvant [Term] id: CHEBI:82891 name: glucocorticoid receptor antagonist namespace: chebi_ontology def: "An antagonist that binds to and deactivates glucocorticoid receptors." [] subset: 3_STAR synonym: "glucocorticoid receptor antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist [Term] id: CHEBI:82892 name: 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole namespace: chebi_ontology def: "A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group." [] subset: 3_STAR is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:25698 ! ether [Term] id: CHEBI:82894 name: (R)-miconazole namespace: chebi_ontology def: "A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has R configuration." [] subset: 3_STAR synonym: "(R)-miconazole" EXACT [UniProt] is_a: CHEBI:82892 ! 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole relationship: is_enantiomer_of CHEBI:82897 ! (S)-miconazole [Term] id: CHEBI:82897 name: (S)-miconazole namespace: chebi_ontology def: "A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has S) configuration." [] subset: 3_STAR synonym: "(S)-miconazole" EXACT [UniProt] is_a: CHEBI:82892 ! 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole relationship: is_enantiomer_of CHEBI:82894 ! (R)-miconazole [Term] id: CHEBI:83039 name: crustacean metabolite namespace: chebi_ontology def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." [] subset: 3_STAR synonym: "crustacean metabolites" RELATED [ChEBI] is_a: CHEBI:75767 ! animal metabolite [Term] id: CHEBI:83056 name: Daphnia magna metabolite namespace: chebi_ontology def: "A Daphnia metabolite produced by the species Daphnia magna." [] subset: 3_STAR synonym: "Daphnia magna metabolites" RELATED [ChEBI] is_a: CHEBI:83057 ! Daphnia metabolite [Term] id: CHEBI:83057 name: Daphnia metabolite namespace: chebi_ontology def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" [] subset: 3_STAR synonym: "Daphnia metabolites" RELATED [ChEBI] xref: Wikipedia:Daphnia is_a: CHEBI:83039 ! crustacean metabolite [Term] id: CHEBI:83060 name: dithiocarbamate salt namespace: chebi_ontology def: "Any salt derived from a member of the class of dithiocarbamic acids by the formal replacement of the hydrogen of the dithiocarboxy group by a metal." [] subset: 3_STAR synonym: "dithiocarbamate salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt relationship: BFO:0000051 CHEBI:84292 ! has part dithiocarbamate anions [Term] id: CHEBI:83072 name: EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor namespace: chebi_ontology def: "An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of succinate dehydrogenase (quinone), EC 1.3.5.1." [] subset: 3_STAR synonym: "complex II inhibitor" RELATED [ChEBI] synonym: "complex II inhibitors" RELATED [ChEBI] synonym: "EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitors" RELATED [ChEBI] synonym: "EC 1.3.5.1 inhibitor" RELATED [ChEBI] synonym: "EC 1.3.5.1 inhibitors" RELATED [ChEBI] synonym: "SDH inhibitor" RELATED [ChEBI] synonym: "SDH inhibitors" RELATED [ChEBI] synonym: "succinate dehydrogenase (ubiquinone) inhibitor" RELATED [ChEBI] synonym: "succinate dehydrogenase (ubiquinone) inhibitors" RELATED [ChEBI] synonym: "succinate dehydrogenase complex inhibitor" RELATED [ChEBI] synonym: "succinate dehydrogenase complex inhibitors" RELATED [ChEBI] synonym: "succinate dehydrogenase inhibitor" RELATED [ChEBI] synonym: "succinate dehydrogenase inhibitors" RELATED [ChEBI] synonym: "succinate:quinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "succinate:quinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "succinate:ubiquinone oxidoreductase inhibitor" RELATED [ChEBI] synonym: "succinate:ubiquinone oxidoreductase inhibitors" RELATED [ChEBI] synonym: "succinic dehydrogenase inhibitor" RELATED [ChEBI] synonym: "succinic dehydrogenase inhibitors" RELATED [ChEBI] xref: Wikipedia:Succinate_dehydrogenase is_a: CHEBI:77102 ! EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor [Term] id: CHEBI:8309 name: polymyxin B1 namespace: chebi_ontology def: "A polymyxin having a (6R)-6-methyloctanoyl group at the amino terminus." [] subset: 3_STAR synonym: "polymycin B" RELATED [ChEBI] synonym: "Polymyxin B(1)" RELATED [ChEBI] synonym: "polymyxin B1" EXACT [ChEBI] is_a: CHEBI:59062 ! polymyxin [Term] id: CHEBI:83146 name: Daphnia tenebrosa metabolite namespace: chebi_ontology def: "A Daphnia metabolite produced by the species Daphnia tenebrosa." [] subset: 3_STAR synonym: "Daphnia tenebrosa metabolites" RELATED [ChEBI] is_a: CHEBI:83057 ! Daphnia metabolite [Term] id: CHEBI:83291 name: 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine namespace: chebi_ontology def: "A member of the class of piperidines that is N-isobutylpiperidine in which a hydrogen of one of the methyl groups is replaced by a p-tert-butylphenyl group." [] subset: 3_STAR synonym: "1-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)piperidine" RELATED [ChemIDplus] is_a: CHEBI:26151 ! piperidines is_a: CHEBI:32876 ! tertiary amine [Term] id: CHEBI:83293 name: (R)-fenpropidin namespace: chebi_ontology def: "A 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine that has R configuration." [] subset: 3_STAR is_a: CHEBI:83291 ! 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine relationship: is_enantiomer_of CHEBI:83294 ! (S)-fenpropidin [Term] id: CHEBI:83294 name: (S)-fenpropidin namespace: chebi_ontology def: "A 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine that has S configuration." [] subset: 3_STAR is_a: CHEBI:83291 ! 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine relationship: is_enantiomer_of CHEBI:83293 ! (R)-fenpropidin [Term] id: CHEBI:83297 name: 4-dodecyl-2,6-dimethylmorpholine namespace: chebi_ontology alt_id: CHEBI:83369 def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a dodecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "2,6-dimethyl-4-dodecylmorpholine" RELATED [ChemIDplus] synonym: "4-dodecyl-2,6-dimethylmorpholine" EXACT [IUPAC] synonym: "N-dodecyl-2,6-dimethylmorpholine" RELATED [ChEBI] xref: PPDB:1128 is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: BFO:0000051 CHEBI:23870 ! has part dodecyl group relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:83316 name: EC 1.14.13.72 (methylsterol monooxygenase) inhibitor namespace: chebi_ontology def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of methylsterol monooxygenase (EC 1.14.13.72)." [] subset: 3_STAR synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitor" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitors" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitor" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitors" RELATED [ChEBI] synonym: "4-methylsterol oxidase inhibitor" RELATED [ChEBI] synonym: "4-methylsterol oxidase inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.72 (ethylsterol monooxygenase) inhibitors" RELATED [ChEBI] synonym: "EC 1.14.13.72 inhibitor" RELATED [ChEBI] synonym: "EC 1.14.13.72 inhibitors" RELATED [ChEBI] synonym: "methylsterol hydroxylase inhibitor" RELATED [ChEBI] synonym: "methylsterol hydroxylase inhibitors" RELATED [ChEBI] synonym: "methylsterol monooxygenase (EC 1.14.13.72) inhibitor" RELATED [ChEBI] synonym: "methylsterol monooxygenase (EC 1.14.13.72) inhibitors" RELATED [ChEBI] synonym: "methylsterol monooxygenase inhibitor" RELATED [ChEBI] synonym: "methylsterol monooxygenase inhibitors" RELATED [ChEBI] xref: Wikipedia:Methylsterol_monooxygenase is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor [Term] id: CHEBI:83317 name: sterol biosynthesis inhibitor namespace: chebi_ontology def: "Any compound that inhibits the biosynthesis of any sterol." [] subset: 3_STAR synonym: "sterol biosynthesis inhibitors" RELATED [ChEBI] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role [Term] id: CHEBI:83319 name: EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor namespace: chebi_ontology def: "An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(14)-sterol reductase (EC 1.3.1.70)." [] subset: 3_STAR synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitor" RELATED [ChEBI] synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitors" RELATED [ChEBI] synonym: "C-14 sterol reductase inhibitor" RELATED [ChEBI] synonym: "C-14 sterol reductase inhibitors" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase (EC 1.3.1.70) inhibitor" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase (EC 1.3.1.70) inhibitors" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase inhibitor" RELATED [ChEBI] synonym: "Delta(14)-sterol reductase inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitors" RELATED [ChEBI] synonym: "EC 1.3.1.70 inhibitor" RELATED [ChEBI] synonym: "EC 1.3.1.70 inhibitors" RELATED [ChEBI] synonym: "sterol C14-reductase inhibitor" RELATED [ChEBI] synonym: "sterol C14-reductase inhibitors" RELATED [ChEBI] xref: Wikipedia:Delta14-sterol_reductase is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor [Term] id: CHEBI:83365 name: 2,6-dimethyl-4-tridecylmorpholine namespace: chebi_ontology def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a tridecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "N-tridecyl-2,6-dimethylmorpholine" RELATED [ChEBI] xref: HMDB:HMDB0031810 xref: KEGG:C11285 is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:83368 name: 2,6-dimethyl-4-undecylmorpholine namespace: chebi_ontology def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by an undecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "2,6-dimethyl-N-undecylmorpholine" RELATED [ChEBI] is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:83370 name: 2,6-dimethyl-4-tetradecylmorpholine namespace: chebi_ontology def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a tetradecyl group. The configuration at positions 2 and 6 is unknown or unspecified." [] subset: 3_STAR synonym: "N-tetradecyl-2,6-dimethylmorpholine" RELATED [ChEBI] is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50996 ! tertiary amino compound relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:83399 name: marine xenobiotic metabolite namespace: chebi_ontology def: "Any metabolite produced by metabolism of a xenobiotic compound in marine macro- and microorganisms." [] subset: 3_STAR synonym: "marine xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:76206 ! xenobiotic metabolite is_a: CHEBI:76507 ! marine metabolite [Term] id: CHEBI:83403 name: monochlorobenzenes namespace: chebi_ontology def: "Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine." [] subset: 3_STAR is_a: CHEBI:23132 ! chlorobenzenes [Term] id: CHEBI:83414 name: alkyl sulfate(1-) namespace: chebi_ontology def: "An organosulfate oxoanion obtained by deprotonation of the sulfo group of any alkyl sulfate; major species at pH 7.3." [] subset: 3_STAR synonym: "alkyl sulfate anion" RELATED [ChEBI] synonym: "an alkyl sulfate" RELATED [UniProt] is_a: CHEBI:58958 ! organosulfate oxoanion relationship: is_conjugate_base_of CHEBI:29281 ! alkyl sulfate [Term] id: CHEBI:83575 name: monofluorobenzenes namespace: chebi_ontology def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying a single fluorine substitutent." [] subset: 3_STAR synonym: "monofluorobenzenes" EXACT [ChEBI] is_a: CHEBI:35496 ! fluorobenzenes [Term] id: CHEBI:83628 name: N-acylammonia namespace: chebi_ontology def: "A carboxamide obtained by the formal condensation of the carboxy group of any carboxylic acid with ammonia." [] subset: 3_STAR synonym: "a monocarboxylic acid amide" RELATED [UniProt] is_a: CHEBI:37622 ! carboxamide [Term] id: CHEBI:83686 name: (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol namespace: chebi_ontology def: "A member of the class of pyrimidines that is pyrimidin-5-ylmethanol in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 2-chlorophenyl group while the other is replaced by a 4-chlorophenyl group." [] subset: 3_STAR xref: PPDB:291 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:39447 ! pyrimidines is_a: CHEBI:83403 ! monochlorobenzenes [Term] id: CHEBI:83688 name: (R)-fenarimol namespace: chebi_ontology def: "A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has R configuration." [] subset: 3_STAR is_a: CHEBI:83686 ! (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol relationship: is_enantiomer_of CHEBI:83689 ! (S)-fenarimol [Term] id: CHEBI:83689 name: (S)-fenarimol namespace: chebi_ontology def: "A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has S configuration." [] subset: 3_STAR is_a: CHEBI:83686 ! (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol relationship: is_enantiomer_of CHEBI:83688 ! (R)-fenarimol [Term] id: CHEBI:83707 name: 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol namespace: chebi_ontology def: "A tertiary alcohol that is ethanol in which one of the hydrogens at position 1 is replaced by an p-fluorophenyl group, the other hydrogen at position 1 is replaced by a p-fluorophenyl group, and one of the hydrogens at position 2 is replaced by a 1H-1,2,4-triazol-1-yl group." [] subset: 3_STAR xref: PPDB:353 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83575 ! monofluorobenzenes [Term] id: CHEBI:83708 name: (R)-flutriafol namespace: chebi_ontology def: "A 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol that has R configuration." [] subset: 3_STAR synonym: "(-)-flutriafol" RELATED [ChEBI] synonym: "(R)-(-)-flutriafol" RELATED [ChEBI] xref: PPDB:3114 is_a: CHEBI:83707 ! 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol relationship: is_enantiomer_of CHEBI:83709 ! (S)-flutriafol [Term] id: CHEBI:83709 name: (S)-flutriafol namespace: chebi_ontology def: "A 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol that has R configuration." [] subset: 3_STAR synonym: "(+)-flutriafol" RELATED [ChEBI] synonym: "(S)-(+)-flutriafol" RELATED [ChEBI] xref: PPDB:3115 is_a: CHEBI:83707 ! 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol relationship: is_enantiomer_of CHEBI:83708 ! (R)-flutriafol [Term] id: CHEBI:83732 name: 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione namespace: chebi_ontology def: "A member of the class of oxazolidinones that is 5-ethenyl-5-methyl-2,4-oxazolidinedione in which the imide hydrogen is replaced by a 3,5-dichlorophenyl group." [] subset: 3_STAR xref: PPDB:680 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:35356 ! dicarboximide is_a: CHEBI:55374 ! oxazolidinone is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:83733 name: (R)-vinclozolin namespace: chebi_ontology def: "A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (R)-enantiomer of vinclozolin." [] subset: 3_STAR is_a: CHEBI:83732 ! 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione relationship: is_enantiomer_of CHEBI:83735 ! (S)-vinclozolin [Term] id: CHEBI:83734 name: sterol demethylation inhibitor namespace: chebi_ontology def: "A sterol biosynthesis inhibitor that acts by inhibiting the C14 demethylation step within fungal steroid biosynthesis." [] subset: 3_STAR synonym: "sterol demethylation inhibitors" RELATED [ChEBI] is_a: CHEBI:35718 ! antifungal agent is_a: CHEBI:83317 ! sterol biosynthesis inhibitor [Term] id: CHEBI:83735 name: (S)-vinclozolin namespace: chebi_ontology def: "A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (S)-enantiomer of vinclozolin." [] subset: 3_STAR is_a: CHEBI:83732 ! 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione relationship: is_enantiomer_of CHEBI:83733 ! (R)-vinclozolin [Term] id: CHEBI:83748 name: 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol namespace: chebi_ontology def: "A tertiary alcohol that is butan-2-ol substituted by a 4-chlorophenyl group at position 2, a cyclopropyl group at position 3 and a 1H-1,2,4-triazol-1-yl group at position 1." [] subset: 3_STAR xref: PPDB:198 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:51454 ! cyclopropanes is_a: CHEBI:83403 ! monochlorobenzenes [Term] id: CHEBI:83749 name: (2R,3S)-cyproconazole namespace: chebi_ontology def: "The (2R,3S)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83752 ! (2S,3R)-cyproconazole [Term] id: CHEBI:83750 name: (2S,3S)-cyproconazole namespace: chebi_ontology def: "The (2S,3S)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83753 ! (2R,3R)-cyproconazole [Term] id: CHEBI:83752 name: (2S,3R)-cyproconazole namespace: chebi_ontology def: "The (2S,3R)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83749 ! (2R,3S)-cyproconazole [Term] id: CHEBI:83753 name: (2R,3R)-cyproconazole namespace: chebi_ontology def: "The (2R,3R)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol." [] subset: 3_STAR is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol relationship: is_enantiomer_of CHEBI:83750 ! (2S,3S)-cyproconazole [Term] id: CHEBI:83758 name: 1-\{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl\}-1H-1,2,4-triazole namespace: chebi_ontology def: "An epoxide that is oxirane substituted by a 2-chlorophenyl, 4-fluorophenyl and a 1H-1,2,4-triazol-1-ylmethyl groups." [] subset: 3_STAR is_a: CHEBI:32955 ! epoxide is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83403 ! monochlorobenzenes is_a: CHEBI:83575 ! monofluorobenzenes [Term] id: CHEBI:83759 name: (2S,3R)-epoxiconazole namespace: chebi_ontology def: "The (2S,3R)-stereoisomer of 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole." [] subset: 3_STAR xref: KEGG:C11229 is_a: CHEBI:83758 ! 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole relationship: is_enantiomer_of CHEBI:83761 ! (2R,3S)-epoxiconazole [Term] id: CHEBI:83761 name: (2R,3S)-epoxiconazole namespace: chebi_ontology def: "The (2R,3S)-stereoisomer of 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole." [] subset: 3_STAR is_a: CHEBI:83758 ! 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole relationship: is_enantiomer_of CHEBI:83759 ! (2S,3R)-epoxiconazole [Term] id: CHEBI:83779 name: 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol namespace: chebi_ontology def: "A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively." [] subset: 3_STAR xref: PPDB:610 is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83403 ! monochlorobenzenes [Term] id: CHEBI:83780 name: (S)-tebuconazole namespace: chebi_ontology def: "The (S)-enantiomer of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol." [] subset: 3_STAR is_a: CHEBI:83779 ! 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol relationship: is_enantiomer_of CHEBI:83781 ! (R)-tebuconazole [Term] id: CHEBI:83781 name: (R)-tebuconazole namespace: chebi_ontology def: "The (R)-enantiomer of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol." [] subset: 3_STAR is_a: CHEBI:83779 ! 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol relationship: is_enantiomer_of CHEBI:83780 ! (S)-tebuconazole [Term] id: CHEBI:83811 name: proteinogenic amino acid derivative namespace: chebi_ontology def: "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." [] subset: 3_STAR synonym: "canonical amino acid derivative" RELATED [ChEBI] synonym: "canonical amino acid derivatives" RELATED [ChEBI] synonym: "canonical amino-acid derivative" RELATED [ChEBI] synonym: "canonical amino-acid derivatives" RELATED [ChEBI] synonym: "proteinogenic amino acid derivatives" RELATED [ChEBI] synonym: "proteinogenic amino-acid derivative" RELATED [ChEBI] synonym: "proteinogenic amino-acid derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino-acid derivative relationship: has_functional_parent CHEBI:83813 ! proteinogenic amino acid [Term] id: CHEBI:83813 name: proteinogenic amino acid namespace: chebi_ontology def: "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." [] subset: 3_STAR synonym: "canonical amino acid" RELATED [ChEBI] synonym: "canonical amino acids" RELATED [ChEBI] synonym: "proteinogenic amino acids" RELATED [ChEBI] xref: Wikipedia:Proteinogenic_amino_acid is_a: CHEBI:33709 ! amino acid [Term] id: CHEBI:83820 name: non-proteinogenic amino acid namespace: chebi_ontology def: "Any amino-acid that is not naturally encoded in the genetic code of any organism." [] subset: 3_STAR synonym: "non-canonical amino acid" RELATED [ChEBI] synonym: "non-canonical amino acids" RELATED [ChEBI] synonym: "non-canonical amino-acid" RELATED [ChEBI] synonym: "non-canonical amino-acids" RELATED [ChEBI] synonym: "non-coded amino acid" RELATED [ChEBI] synonym: "non-coded amino acids" RELATED [ChEBI] synonym: "non-coded amino-acid" RELATED [ChEBI] synonym: "non-coded amino-acids" RELATED [ChEBI] synonym: "non-proteinogenic amino acids" RELATED [ChEBI] synonym: "non-proteinogenic amino-acid" RELATED [ChEBI] synonym: "non-proteinogenic amino-acids" RELATED [ChEBI] xref: Wikipedia:Non-proteinogenic_amino_acids is_a: CHEBI:33709 ! amino acid [Term] id: CHEBI:83821 name: amino-acid derivative namespace: chebi_ontology alt_id: CHEBI:25359 def: "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." [] subset: 3_STAR synonym: "amino acid derivative" RELATED [ChEBI] synonym: "amino acid derivatives" RELATED [ChEBI] synonym: "amino-acid derivatives" RELATED [ChEBI] synonym: "modified amino acids" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound [Term] id: CHEBI:83876 name: cationic sphingoid namespace: chebi_ontology def: "An organic cation obtained by protonation of the amino function of any sphingoid" [] subset: 3_STAR synonym: "cationic sphingoids" RELATED [ChEBI] synonym: "sphingoid cation" RELATED [ChEBI] synonym: "sphingoid cations" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:35785 ! sphingoid [Term] id: CHEBI:83906 name: (S)-diniconazole namespace: chebi_ontology def: "A (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the (S)-enantiomer of diniconazole." [] subset: 3_STAR synonym: "(+)-diniconazole" RELATED [ChEBI] synonym: "diniconazole (+)-form" RELATED [ChemIDplus] synonym: "S-(+)-diniconazole" RELATED [ChEBI] is_a: CHEBI:83909 ! (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol relationship: is_enantiomer_of CHEBI:83911 ! diniconazole-M [Term] id: CHEBI:83909 name: (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol namespace: chebi_ontology def: "A member of the class of triazoles that is 4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol substituted at position 1 by a 2,4-dichlorophenyl group." [] subset: 3_STAR xref: PPDB:247 is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:78840 ! olefinic compound [Term] id: CHEBI:83911 name: diniconazole-M namespace: chebi_ontology def: "A (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the active R-enantiomer of diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts." [] subset: 3_STAR synonym: "(-)-diniconazole" RELATED [ChEBI] synonym: "(E)-(R)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" RELATED [Alan_Wood's_Pesticides] synonym: "(R)-diniconazole" RELATED [ChEBI] synonym: "diniconazole (-)" RELATED [ChemIDplus] synonym: "R-(-)-diniconazole" RELATED [ChEBI] xref: PPDB:2907 is_a: CHEBI:83909 ! (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol is_a: CHEBI:87067 ! conazole fungicide relationship: is_enantiomer_of CHEBI:83906 ! (S)-diniconazole relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:83925 name: non-proteinogenic alpha-amino acid namespace: chebi_ontology def: "Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." [] subset: 3_STAR synonym: "non-proteinogenic alpha-amino acids" RELATED [ChEBI] synonym: "non-proteinogenic alpha-amino-acid" RELATED [ChEBI] synonym: "non-proteinogenic alpha-amino-acids" RELATED [ChEBI] is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:83820 ! non-proteinogenic amino acid [Term] id: CHEBI:83955 name: 2-saturated fatty acid anion namespace: chebi_ontology def: "A fatty acid anion obtained by deprotonation of the carboxy group of any 2-saturated fatty acid." [] subset: 3_STAR synonym: "1,2-saturated fatty acid anion" RELATED [ChEBI] synonym: "a 1,2-saturated fatty acid" RELATED [UniProt] is_a: CHEBI:28868 ! fatty acid anion [Term] id: CHEBI:83986 name: ethylenebis(dithiocarbamic acid) namespace: chebi_ontology def: "A dithiocarbamic acid resulting from the formal addition of a molecule of carbon disulfide to each amino group of ethylenediamine." [] subset: 3_STAR synonym: "ethylenebisdithiocarbamic acid" RELATED [ChemIDplus] synonym: "N,N'-(ethylene)bisdithiocarbamic acid" RELATED [ChEBI] synonym: "N,N'-ethanediylbis(dithiocarbamic acid)" RELATED [ChEBI] is_a: CHEBI:78787 ! dithiocarbamic acids relationship: has_functional_parent CHEBI:30347 ! ethylenediamine relationship: is_conjugate_acid_of CHEBI:77308 ! ethylenebis(dithiocarbamate) [Term] id: CHEBI:84002 name: 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one namespace: chebi_ontology def: "A member of the class of triazoles that is 1-hydroxy-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one in which the hydroxyl hydrogen is replaced by a 4-chlorophenyl group." [] subset: 3_STAR xref: LINCS:LSM-4424 xref: PPDB:648 is_a: CHEBI:141498 ! hemiaminal ether is_a: CHEBI:17087 ! ketone is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:35727 ! triazoles is_a: CHEBI:83403 ! monochlorobenzenes [Term] id: CHEBI:84003 name: (R)-triadimefon namespace: chebi_ontology def: "A 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one that is the (R)-enantiomer of triadimefon." [] subset: 3_STAR is_a: CHEBI:84002 ! 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one relationship: is_enantiomer_of CHEBI:84004 ! (S)-triadimefon [Term] id: CHEBI:84004 name: (S)-triadimefon namespace: chebi_ontology def: "A 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one that is the (S)-enantiomer of triadimefon." [] subset: 3_STAR is_a: CHEBI:84002 ! 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one relationship: is_enantiomer_of CHEBI:84003 ! (R)-triadimefon [Term] id: CHEBI:84055 name: pentose phosphate namespace: chebi_ontology def: "Any phospho sugar that is the phosphate derivative of pentose." [] subset: 3_STAR synonym: "pentose phosphates" RELATED [ChEBI] is_a: CHEBI:33447 ! phospho sugar is_a: CHEBI:63409 ! pentose derivative [Term] id: CHEBI:84087 name: human urinary metabolite namespace: chebi_ontology def: "Any metabolite (endogenous or exogenous) found in human urine samples." [] subset: 3_STAR synonym: "human urinary metabolites" RELATED [ChEBI] is_a: CHEBI:77746 ! human metabolite [Term] id: CHEBI:84186 name: L-proline derivative namespace: chebi_ontology def: "A proteinogenic amino acid derivative resulting from reaction of L-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of L-proline by a heteroatom." [] subset: 3_STAR synonym: "L-proline derivatives" RELATED [ChEBI] is_a: CHEBI:26273 ! proline derivative is_a: CHEBI:83811 ! proteinogenic amino acid derivative relationship: has_functional_parent CHEBI:17203 ! L-proline [Term] id: CHEBI:84264 name: EC 3.5.1.19 (nicotinamidase) inhibitor namespace: chebi_ontology def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of nicotinamidase (EC 3.5.1.19)." [] subset: 3_STAR synonym: "EC 3.5.1.19 (nicotinamidase) inhibitors" RELATED [ChEBI] synonym: "EC 3.5.1.19 inhibitor" RELATED [ChEBI] synonym: "EC 3.5.1.19 inhibitors" RELATED [ChEBI] synonym: "nicotinamidase (EC 3.5.1.19) inhibitor" RELATED [ChEBI] synonym: "nicotinamidase (EC 3.5.1.19) inhibitors" RELATED [ChEBI] synonym: "nicotinamidase inhibitor" RELATED [ChEBI] synonym: "nicotinamidase inhibitors" RELATED [ChEBI] synonym: "nicotinamide amidase inhibitor" RELATED [ChEBI] synonym: "nicotinamide amidase inhibitors" RELATED [ChEBI] synonym: "nicotinamide amidohydrolase inhibitor" RELATED [ChEBI] synonym: "nicotinamide amidohydrolase inhibitors" RELATED [ChEBI] synonym: "nicotinamide deaminase inhibitor" RELATED [ChEBI] synonym: "nicotinamide deaminase inhibitors" RELATED [ChEBI] synonym: "YNDase inhibitor" RELATED [ChEBI] synonym: "YNDase inhibitors" RELATED [ChEBI] xref: Wikipedia:Nicotinamidase is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor [Term] id: CHEBI:84291 name: organic sulfur anion namespace: chebi_ontology def: "An organic anion in which the charge resides on a sulfur atom." [] subset: 3_STAR synonym: "organic sulfur anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:26835 ! sulfur molecular entity [Term] id: CHEBI:84292 name: dithiocarbamate anions namespace: chebi_ontology def: "Any organic sulfur anion resulting from the removal of a proton from any N-substituted dithiocarbamic acid." [] subset: 3_STAR is_a: CHEBI:84291 ! organic sulfur anion relationship: is_conjugate_base_of CHEBI:78787 ! dithiocarbamic acids [Term] id: CHEBI:8434 name: prochloraz namespace: chebi_ontology def: "A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables." [] subset: 3_STAR xref: KEGG:C11182 xref: PPDB:536 is_a: CHEBI:27096 ! trichlorobenzene is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:47857 ! ureas is_a: CHEBI:60600 ! amide fungicide is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87068 ! imidazole fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:84735 name: algal metabolite namespace: chebi_ontology def: "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." [] subset: 3_STAR synonym: "algal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite [Term] id: CHEBI:84739 name: amikacin(4+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the four free amino groups of amikacin; major species at pH 7.3." [] subset: 3_STAR synonym: "amikacin" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:2637 ! amikacin [Term] id: CHEBI:8489 name: propiconazole namespace: chebi_ontology alt_id: CHEBI:658576 def: "The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds." [] subset: 3_STAR synonym: "(+-)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole" RELATED [ChEBI] synonym: "Propiconazole" EXACT [KEGG_COMPOUND] xref: KEGG:C11121 xref: MetaCyc:CPD-14540 xref: Patent:DE2551560 xref: Patent:US4079062 xref: PPDB:551 xref: Wikipedia:Propiconazole is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:59779 ! cyclic ketal is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:85251 name: teicoplanin A2-2 namespace: chebi_ontology def: "A teicoplanin A2 that has 8-methylnonanoyl as the variable N-acyl group." [] subset: 3_STAR synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((8-methyl-1-oxononyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChemIDplus] synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(8-methyl-1-oxononyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [ChEBI] synonym: "teichomycin A2 factor 2" RELATED [ChemIDplus] synonym: "teicoplanin A2-2" EXACT [ChemIDplus] xref: Patent:US4542018 is_a: CHEBI:34994 ! teicoplanin A2 relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:86323 name: conazole antifungal agent namespace: chebi_ontology alt_id: CHEBI:60593 def: "A compound that has a structure that is related to miconazole, contains an azole (imidazole or triazole) moiety, and has significant systemic antifungal properties. They inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function." [] subset: 3_STAR synonym: "azole antibiotic" RELATED [ChEBI] synonym: "azole antibiotics" RELATED [ChEBI] synonym: "conazole antifungal agents" RELATED [ChEBI] is_a: CHEBI:68452 ! azole relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent relationship: RO:0000087 CHEBI:75282 ! has role ergosterol biosynthesis inhibitor [Term] id: CHEBI:86324 name: quinolone antibiotic namespace: chebi_ontology def: "An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton." [] subset: 3_STAR synonym: "quinolone antibiotics" RELATED [ChEBI] is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic [Term] id: CHEBI:86327 name: antifungal drug namespace: chebi_ontology def: "Any antifungal agent used to prevent or treat fungal infections in humans or animals." [] subset: 3_STAR synonym: "anti-fungal drug" RELATED [ChEBI] synonym: "anti-fungal drugs" RELATED [ChEBI] synonym: "anti-fungal medication" RELATED [ChEBI] synonym: "anti-fungal medications" RELATED [ChEBI] synonym: "antifungal drugs" RELATED [ChEBI] synonym: "antifungal medication" RELATED [ChEBI] synonym: "antifungal medications" RELATED [ChEBI] synonym: "pharmaceutical fungicide" RELATED [ChEBI] synonym: "pharmaceutical fungicides" RELATED [ChEBI] xref: Wikipedia:Antifungal is_a: CHEBI:35441 ! antiinfective agent is_a: CHEBI:35718 ! antifungal agent [Term] id: CHEBI:86328 name: antifungal agrochemical namespace: chebi_ontology def: "Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties." [] subset: 3_STAR synonym: "agrichemical fungicide" RELATED [ChEBI] synonym: "agrichemical fungicides" RELATED [ChEBI] synonym: "agrochemical fungicide" RELATED [ChEBI] synonym: "agrochemical fungicides" RELATED [ChEBI] synonym: "anti-fungal agrichemical" RELATED [ChEBI] synonym: "anti-fungal agrichemicals" RELATED [ChEBI] synonym: "anti-fungal agrochemical" RELATED [ChEBI] synonym: "anti-fungal agrochemicals" RELATED [ChEBI] synonym: "antifungal agrichemical" RELATED [ChEBI] synonym: "antifungal agrichemicals" RELATED [ChEBI] synonym: "antifungal agrochemicals" RELATED [ChEBI] is_a: CHEBI:24127 ! fungicide is_a: CHEBI:33286 ! agrochemical [Term] id: CHEBI:86411 name: cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine namespace: chebi_ontology def: "Either of the two diastereoisomers of 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine in which the imidazol-1-ylmethyl group and the aryloxymethyl group are in a cis relationship to each other - i.e. they are both on the same side of the plane of the dioxolane ring. The antifungal drug ketoconazole is a racemic mixture of the two cis diastereoisomers." [] subset: 3_STAR is_a: CHEBI:48339 ! 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine [Term] id: CHEBI:86420 name: imidazole antifungal agent namespace: chebi_ontology def: "A compound that has significant antifungal properties whose structure contains an imidazole moiety." [] subset: 3_STAR synonym: "imidazole antifungal agents" RELATED [ChEBI] is_a: CHEBI:24780 ! imidazoles relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:86426 name: triazole antifungal agent namespace: chebi_ontology def: "A member of the class of triazole that has significant antifungal properties." [] subset: 3_STAR synonym: "triazole antifungal agents" RELATED [ChEBI] is_a: CHEBI:35727 ! triazoles relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:86478 name: antibiotic antifungal agent namespace: chebi_ontology def: "Heteroorganic entities that are microbial metabolites (or compounds derived from them) which have significant antifungal properties." [] subset: 3_STAR synonym: "antibiotic antifungal agents" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:86482 name: strobilurin antifungal agent namespace: chebi_ontology def: "Any antibiotic antifungal agents whose structure is based on the antifungal agents originally isolated from the fungus Strobilurus tenacellus." [] subset: 3_STAR synonym: "strobilurin antifungal agents" RELATED [ChEBI] xref: Wikipedia:Strobilurin is_a: CHEBI:86478 ! antibiotic antifungal agent [Term] id: CHEBI:86484 name: methoxyacrylate strobilurin antifungal agent namespace: chebi_ontology def: "Any strobilurin antifungal agent that contains a methoxyacrylate group." [] subset: 3_STAR synonym: "methoxyacrylate strobilurin antifungal agents" RELATED [ChEBI] is_a: CHEBI:25248 ! methyl ester is_a: CHEBI:51702 ! enoate ester is_a: CHEBI:86482 ! strobilurin antifungal agent [Term] id: CHEBI:8653 name: pyocyanine namespace: chebi_ontology alt_id: CHEBI:137500 def: "An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by Pseudomonas aeruginosa." [] subset: 3_STAR synonym: "pyocyanin" RELATED [ChEBI] xref: Chemspider:6558 xref: KEGG:C01748 xref: MetaCyc:CPD-12847 xref: PDBeChem:3J8 xref: Wikipedia:Pyocyanin is_a: CHEBI:35285 ! iminium betaine is_a: CHEBI:39201 ! phenazines relationship: is_conjugate_base_of CHEBI:62220 ! pyocyanine(1+) relationship: RO:0000087 CHEBI:26130 ! has role biological pigment relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent relationship: RO:0000087 CHEBI:72316 ! has role virulence factor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:8674 name: pyrimethanil namespace: chebi_ontology def: "A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine." [] subset: 3_STAR synonym: "2-Anilino-4,6-dimethylpyrimidine" RELATED [HMDB] synonym: "4,6-Dimethyl-N-phenyl-2-pyrimidinamine" RELATED [HMDB] synonym: "N-(4,6-dimethylpyrimidin-2-yl)aniline" RELATED [Alan_Wood's_Pesticides] xref: HMDB:HMDB0033135 xref: KEGG:C11180 xref: PPDB:573 xref: Wikipedia:Pyrimethanil is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:50995 ! secondary amino compound is_a: CHEBI:87208 ! anilinopyrimidine fungicide relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:72768 ! has role aryl hydrocarbon receptor agonist relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:87012 name: amide antifungal agent namespace: chebi_ontology def: "A compound that has significant antifungal properties whose structure contains an amide moiety." [] subset: 3_STAR synonym: "amide antifungal agents" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87015 name: anilide fungicide namespace: chebi_ontology def: "Any amide fungicide whose structure contains an anilide group." [] subset: 3_STAR synonym: "anilide fungicides" RELATED [ChEBI] is_a: CHEBI:60600 ! amide fungicide [Term] id: CHEBI:87034 name: aromatic fungicide namespace: chebi_ontology def: "An organic aromatic compound that has been used as a fungicide." [] subset: 3_STAR synonym: "aromatic fungicides" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87036 name: benzimidazole fungicide namespace: chebi_ontology def: "Compounds that contain a benzimidazole moiety as a key feature of their structure and which have been used as fungicides." [] subset: 3_STAR synonym: "benzimidazole fungicides" RELATED [ChEBI] is_a: CHEBI:22715 ! benzimidazoles relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87037 name: benzimidazole precursor fungicide namespace: chebi_ontology def: "Compounds based on 1,2-phenylenediamine in which one or both of the primary amino groups have been derivatised so as to permit subsequent benzimidazole formation, and which have been used as fungicides." [] subset: 3_STAR synonym: "benzimidazole precursor fungicides" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: has_functional_parent CHEBI:34043 ! 1,2-phenylenediamine relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87061 name: carbamate fungicide namespace: chebi_ontology def: "Compounds that contain a carbamate ester moiety as a key feature of their structure and which have been used as fungicides." [] subset: 3_STAR synonym: "carbamate fungicides" RELATED [ChEBI] is_a: CHEBI:23003 ! carbamate ester relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87064 name: benzimidazolylcarbamate fungicide namespace: chebi_ontology def: "Any carbamate fungicide that contains a benzimidazolyl group attached to the nitrogen of the carbamate moiety." [] subset: 3_STAR synonym: "benzimidazolylcarbamate fungicides" RELATED [ChEBI] is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:87061 ! carbamate fungicide [Term] id: CHEBI:87066 name: carbanilate fungicide namespace: chebi_ontology def: "Any carbamate fungicide that has a phenyl or substituted-phenyl group attached to the nitrogen of the carbamate group." [] subset: 3_STAR synonym: "carbanilate fungicides" RELATED [ChEBI] is_a: CHEBI:87061 ! carbamate fungicide [Term] id: CHEBI:87067 name: conazole fungicide namespace: chebi_ontology def: "Any conazole antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "conazole fungicides" RELATED [ChEBI] is_a: CHEBI:86323 ! conazole antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87068 name: imidazole fungicide namespace: chebi_ontology def: "Any imidazole antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "imidazole fungicides" RELATED [ChEBI] is_a: CHEBI:86420 ! imidazole antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87069 name: imidazole antifungal drug namespace: chebi_ontology def: "Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] subset: 3_STAR synonym: "imidazole antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86420 ! imidazole antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87071 name: conazole antifungal drug namespace: chebi_ontology def: "Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans." [] subset: 3_STAR synonym: "conazole antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86323 ! conazole antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87100 name: triazole fungicide namespace: chebi_ontology def: "Any triazole antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "triazole fungicides" RELATED [ChEBI] is_a: CHEBI:86426 ! triazole antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87101 name: triazole antifungal drug namespace: chebi_ontology def: "Any triazole antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] subset: 3_STAR synonym: "triazole antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86426 ! triazole antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87113 name: antibiotic antifungal drug namespace: chebi_ontology def: "Any antibiotic antifungal agent used to treat fungal infections in humans or animals." [] subset: 3_STAR synonym: "antibiotic antifungal drugs" RELATED [ChEBI] is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87114 name: antibiotic fungicide namespace: chebi_ontology def: "Any antibiotic antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "antibiotic fungicides" RELATED [ChEBI] is_a: CHEBI:86478 ! antibiotic antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87127 name: allylamine antifungal drug namespace: chebi_ontology def: "An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug." [] subset: 3_STAR synonym: "allylamine antifungal drugs" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87132 name: morpholine antifungal agent namespace: chebi_ontology def: "A member of the class of morpholines that has significant antifungal properties." [] subset: 3_STAR synonym: "morpholine antifungal agents" RELATED [ChEBI] is_a: CHEBI:38785 ! morpholines relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87134 name: morpholine fungicide namespace: chebi_ontology def: "Any morpholine antifungal agent used as a fungicide." [] subset: 3_STAR synonym: "morpholine fungicides" RELATED [ChEBI] is_a: CHEBI:87132 ! morpholine antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87185 name: florfenicol namespace: chebi_ontology def: "A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture." [] subset: 3_STAR synonym: "(-)-Florfenicol" RELATED [ChemIDplus] synonym: "D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide" RELATED [ChemIDplus] synonym: "Sch 25298" RELATED [ChemIDplus] synonym: "Sch-25298" RELATED [ChemIDplus] xref: KEGG:D04194 xref: LINCS:LSM-5287 xref: Patent:EP14437 xref: Patent:US4235892 xref: VSDB:1777 xref: Wikipedia:Florfenicol is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:35850 ! sulfone is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:37143 ! organofluorine compound relationship: has_functional_parent CHEBI:36386 ! dichloroacetic acid relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:87195 name: dicarboximide fungicide namespace: chebi_ontology def: "Any dicarboximide antifungal agent used as a fungicide." [] subset: 3_STAR synonym: "dicarboximide fungicides" RELATED [ChEBI] is_a: CHEBI:87200 ! dicarboximide antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87197 name: dichlorophenyl dicarboximide fungicide namespace: chebi_ontology def: "A dicarboximide fungicide in which the nitrogen of the dicarboximide group is substituted by a dichlorophenyl group." [] subset: 3_STAR synonym: "dichlorophenyl dicarboximide fungicides" RELATED [ChEBI] is_a: CHEBI:23697 ! dichlorobenzene is_a: CHEBI:87195 ! dicarboximide fungicide [Term] id: CHEBI:87198 name: phthalimide fungicide namespace: chebi_ontology def: "A dicarboximide fungicide whose structure contains a phthalimide derivative." [] subset: 3_STAR synonym: "phthalimide fungicides" RELATED [ChEBI] is_a: CHEBI:87195 ! dicarboximide fungicide [Term] id: CHEBI:87200 name: dicarboximide antifungal agent namespace: chebi_ontology def: "A compound that has significant antifungal properties whose structure contains a dicarboximide moiety." [] subset: 3_STAR synonym: "dicarboximide antifungal agents" RELATED [ChEBI] is_a: CHEBI:35356 ! dicarboximide relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87204 name: pyrimidine antifungal agent namespace: chebi_ontology def: "A member of the class of pyrimidines that has significant antifungal properties." [] subset: 3_STAR synonym: "pyrimidine antifungal agents" RELATED [ChEBI] is_a: CHEBI:39447 ! pyrimidines relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent [Term] id: CHEBI:87205 name: pyrimidine antifungal drug namespace: chebi_ontology def: "Any pyrimidine antifungal agent that has been used for the treatment of fungal infections in humans or animals." [] subset: 3_STAR synonym: "pyrimidine antifungal drugs" RELATED [ChEBI] is_a: CHEBI:87204 ! pyrimidine antifungal agent relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug [Term] id: CHEBI:87207 name: pyrimidine fungicide namespace: chebi_ontology def: "Any pyrimidine antifungal agent that has been used as a fungicide." [] subset: 3_STAR synonym: "pyrimidine fungicides" RELATED [ChEBI] is_a: CHEBI:87204 ! pyrimidine antifungal agent relationship: RO:0000087 CHEBI:24127 ! has role fungicide [Term] id: CHEBI:87208 name: anilinopyrimidine fungicide namespace: chebi_ontology def: "Any pyrimidine fungicide in which the pyrimidine ring is substituted by the nitrogen of an aniline moiety." [] subset: 3_STAR synonym: "anilinopyrimidine fungicides" RELATED [ChEBI] is_a: CHEBI:87207 ! pyrimidine fungicide [Term] id: CHEBI:87209 name: virginiamycin namespace: chebi_ontology def: "A mixture of cyclic polypeptide streptogramin antibiotics produced by Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. The two major components are virginiamycin M1 (also known as pristinamycin IIA) and virginiamycin S1. Virginiamycin has been widely used as a growth promotion agent in livestock and has been to have bacteriostatic activity against Gram-positive organisms such as staphylococci and streptococci." [] subset: 3_STAR synonym: "virginiamycins" RELATED [ChEBI] xref: HMDB:HMDB0030520 xref: KEGG:D06311 xref: Wikipedia:Virginiamycin is_a: CHEBI:60004 ! mixture relationship: BFO:0000051 CHEBI:46416 ! has part virginiamycin S1 relationship: BFO:0000051 CHEBI:9997 ! has part pristinamycin IIA relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:87211 name: fluoroquinolone antibiotic namespace: chebi_ontology def: "An organonitrogen heterocyclic antibiotic containing a quinolone (or quinolone-like) moiety and which have a fluorine atom attached to the central ring system." [] subset: 3_STAR synonym: "fluoroquinolone antibiotics" RELATED [ChEBI] is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:37143 ! organofluorine compound [Term] id: CHEBI:87228 name: sulfonamide antibiotic namespace: chebi_ontology def: "A class of sulfonamides whose members generally have bacteriostatic antibiotic properties." [] subset: 3_STAR synonym: "sulfonamide antibiotics" RELATED [ChEBI] synonym: "sulfonamide antimicrobial agent" RELATED [ChEBI] synonym: "sulfonamide antimicrobial agents" RELATED [ChEBI] synonym: "sulphonamide antibiotic" RELATED [ChEBI] synonym: "sulphonamide antibiotics" RELATED [ChEBI] xref: Wikipedia:Sulfonamide_(medicine) is_a: CHEBI:35358 ! sulfonamide relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent [Term] id: CHEBI:87230 name: nitrofuran antibiotic namespace: chebi_ontology def: "A member of the class of furans in which the furan ring is substituted by a nitro group and which also has significant antibiotic properties." [] subset: 3_STAR synonym: "nitrofuran antibiotics" RELATED [ChEBI] synonym: "nitrofuran antimicrobial agent" RELATED [ChEBI] synonym: "nitrofuran antimicrobial agents" RELATED [ChEBI] xref: Wikipedia:Nitrofuran is_a: CHEBI:24129 ! furans is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic is_a: CHEBI:35716 ! C-nitro compound [Term] id: CHEBI:8733 name: Quinupristin-dalfopristin namespace: chebi_ontology subset: 2_STAR synonym: "Quinupristin-dalfopristin" EXACT [KEGG_COMPOUND] xref: KEGG:C08034 xref: KEGG:D00854 is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:87835 name: framycetin(6+) namespace: chebi_ontology def: "An organic cation obtained by protonation of the six amino groups of framycetin; major species at pH 7.3." [] subset: 3_STAR synonym: "neomycin B" RELATED [UniProt] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:35274 ! ammonium ion derivative relationship: is_conjugate_acid_of CHEBI:7508 ! framycetin [Term] id: CHEBI:88061 name: polyamine namespace: chebi_ontology def: "Any organic amino compound that contains two or more amino groups." [] subset: 3_STAR synonym: "polyamines" RELATED [ChEBI] xref: Wikipedia:Polyamine is_a: CHEBI:50047 ! organic amino compound [Term] id: CHEBI:88184 name: metal allergen namespace: chebi_ontology def: "Any metal which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic metal" RELATED [ChEBI] synonym: "allergenic metals" RELATED [ChEBI] synonym: "metal allergens" RELATED [ChEBI] is_a: CHEBI:33521 ! metal atom relationship: RO:0000087 CHEBI:50904 ! has role allergen [Term] id: CHEBI:88187 name: penicillin allergen namespace: chebi_ontology def: "Any penicillin which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic penicillin" RELATED [ChEBI] synonym: "allergenic penicillin compound" RELATED [ChEBI] synonym: "allergenic penicillin compounds" RELATED [ChEBI] synonym: "allergenic penicillins" RELATED [ChEBI] synonym: "penicillin allergens" RELATED [ChEBI] is_a: CHEBI:17334 ! penicillin [Term] id: CHEBI:88188 name: drug allergen namespace: chebi_ontology def: "Any drug which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic drug" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:50904 ! allergen [Term] id: CHEBI:88225 name: beta-lactam antibiotic allergen namespace: chebi_ontology def: "Any beta-lactam antibiotic which causes the onset of an allergic reaction." [] subset: 3_STAR synonym: "allergenic beta-lactam antibiotic" RELATED [ChEBI] synonym: "allergenic beta-lactam antibiotics" RELATED [ChEBI] synonym: "beta-lactam antibiotic allergens" RELATED [ChEBI] is_a: CHEBI:27933 ! beta-lactam antibiotic relationship: RO:0000087 CHEBI:50904 ! has role allergen [Term] id: CHEBI:88227 name: potassium ionophore namespace: chebi_ontology def: "Any ionophore capable of transportation of potassium ions across membranes." [] subset: 3_STAR synonym: "potassium ionophores" RELATED [ChEBI] is_a: CHEBI:24869 ! ionophore [Term] id: CHEBI:8984 name: sodium dodecyl sulfate namespace: chebi_ontology def: "An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate." [] subset: 3_STAR synonym: "SDS" RELATED [KEGG_COMPOUND] synonym: "SLS" RELATED [ChemIDplus] synonym: "Sodium dodecyl sulfate" EXACT [KEGG_COMPOUND] synonym: "sodium dodecyl sulphate" RELATED [ChemIDplus] synonym: "sodium dodecylsulfate" RELATED [ChemIDplus] synonym: "Sodium lauryl sulfate" RELATED [KEGG_COMPOUND] synonym: "sodium lauryl sulphate" RELATED [ChemIDplus] xref: DrugBank:DB00815 xref: KEGG:C11166 xref: KEGG:D01045 is_a: CHEBI:38700 ! organic sodium salt relationship: BFO:0000051 CHEBI:23872 ! has part dodecyl sulfate relationship: RO:0000087 CHEBI:27780 ! has role detergent relationship: RO:0000087 CHEBI:50533 ! has role protein denaturant [Term] id: CHEBI:90710 name: receptor modulator namespace: chebi_ontology alt_id: CHEBI:189678 def: "A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors." [] subset: 3_STAR synonym: "receptor modulators" RELATED [ChEBI] xref: Wikipedia:Receptor_modulator is_a: CHEBI:23888 ! drug [Term] id: CHEBI:90799 name: dipeptide zwitterion namespace: chebi_ontology def: "Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3." [] subset: 3_STAR synonym: "a dipeptide" RELATED [UniProt] is_a: CHEBI:60466 ! peptide zwitterion relationship: is_tautomer_of CHEBI:46761 ! dipeptide [Term] id: CHEBI:91007 name: aromatic carboxylate namespace: chebi_ontology def: "A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3." [] subset: 3_STAR synonym: "an aromatic carboxylate" RELATED [UniProt] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:33859 ! aromatic carboxylic acid [Term] id: CHEBI:9168 name: sirolimus namespace: chebi_ontology alt_id: CHEBI:45276 alt_id: CHEBI:67812 def: "A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent." [] subset: 3_STAR synonym: "(-)-Rapamycin" RELATED [ChemIDplus] synonym: "(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone" RELATED [IUPAC] synonym: "Antibiotic AY 22989" RELATED [DrugBank] synonym: "rapamycin" RELATED [ChEBI] synonym: "Sirolimus" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00877 xref: HMDB:HMDB0015015 xref: KEGG:C07909 xref: KEGG:D00753 xref: KNApSAcK:C00018055 xref: PDBeChem:RAP xref: Wikipedia:Rapamycin is_a: CHEBI:145565 ! macrolide lactam is_a: CHEBI:25698 ! ether is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:59770 ! cyclic acetal is_a: CHEBI:87113 ! antibiotic antifungal drug relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent relationship: RO:0000087 CHEBI:176497 ! has role geroprotector relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:68481 ! has role mTOR inhibitor relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:9212 name: sparfloxacin namespace: chebi_ontology subset: 3_STAR synonym: "cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid" RELATED [KEGG_COMPOUND] synonym: "Sparfloxacin" EXACT [KEGG_COMPOUND] xref: DrugBank:DB01208 xref: KEGG:C07662 xref: KEGG:D00590 xref: LINCS:LSM-5251 xref: Wikipedia:Sparfloxacin is_a: CHEBI:23765 ! quinolone is_a: CHEBI:26512 ! quinolinemonocarboxylic acid is_a: CHEBI:46848 ! N-arylpiperazine is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic [Term] id: CHEBI:9215 name: spectinomycin namespace: chebi_ontology alt_id: CHEBI:45551 def: "A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis." [] subset: 3_STAR synonym: "Antibiotic 2233wp" RELATED [ChemIDplus] xref: DrugBank:DB00919 xref: HMDB:HMDB0015055 xref: KEGG:C02078 xref: KEGG:D08526 xref: LINCS:LSM-5298 xref: Patent:US4203903 xref: Patent:WO2005041984 xref: PDBeChem:SCM xref: Wikipedia:Spectinomycin is_a: CHEBI:146295 ! pyranobenzodioxin is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:50995 ! secondary amino compound is_a: CHEBI:59770 ! cyclic acetal is_a: CHEBI:59780 ! cyclic hemiketal relationship: is_conjugate_base_of CHEBI:146260 ! spectinomycin(1+) relationship: is_conjugate_base_of CHEBI:77315 ! spectinomycin(2+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite [Term] id: CHEBI:9242 name: spiroxamine namespace: chebi_ontology alt_id: CHEBI:546779 def: "The spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powdery mildew in the production of cereals, bananas and grapes." [] subset: 3_STAR synonym: "(8-tert-Butyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-ethyl-propyl-amine" RELATED [ChEMBL] synonym: "8-(1,1-dimethylethyl)-N-ethyl-N-propyl-1,4-dioxaspiro(4.5)decane-2-methanamine" RELATED [ChEBI] synonym: "KWG4168" RELATED [KEGG_COMPOUND] synonym: "Spiroxamine" EXACT [KEGG_COMPOUND] xref: KEGG:C11124 xref: Patent:DE3735555 xref: Patent:US4851405 xref: PPDB:599 is_a: CHEBI:39430 ! dioxolane is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:72600 ! spiroketal relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:9321 name: sulbactam namespace: chebi_ontology subset: 3_STAR synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide" RELATED [ChemIDplus] synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide" RELATED [IUPAC] synonym: "CP 45899" RELATED [DrugBank] synonym: "CP-45899" RELATED [DrugBank] synonym: "CP45899" RELATED [DrugBank] synonym: "penicillanic acid 1,1-dioxide" RELATED [ChEBI] synonym: "penicillanic acid sulfone" RELATED [ChEBI] xref: HMDB:HMDB0258566 xref: KEGG:C07770 xref: KEGG:D08533 xref: LINCS:LSM-5553 xref: Patent:BE867859 xref: Patent:US4234579 xref: PDBeChem:0RN xref: Wikipedia:Sulbactam is_a: CHEBI:25865 ! penicillanic acids relationship: is_conjugate_acid_of CHEBI:229543 ! sulbactam(1-) [Term] id: CHEBI:9448 name: terbinafine namespace: chebi_ontology def: "A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections." [] subset: 3_STAR synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine" RELATED [ChemIDplus] synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine" RELATED [ChemIDplus] synonym: "terbinafine" EXACT [WHO_MedNet] xref: DrugBank:DB00857 xref: HMDB:HMDB0014995 xref: KEGG:C08079 xref: KEGG:D02375 xref: MetaCyc:CPD-10571 xref: Wikipedia:Terbinafine is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:32876 ! tertiary amine is_a: CHEBI:59831 ! enyne is_a: CHEBI:87127 ! allylamine antifungal drug relationship: is_conjugate_base_of CHEBI:77615 ! terbinafine(1+) relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor relationship: RO:0000087 CHEBI:59285 ! has role EC 1.14.13.132 (squalene monooxygenase) inhibitor relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor [Term] id: CHEBI:94759 name: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole namespace: chebi_ontology subset: 2_STAR synonym: "fasinex" RELATED [DrugCentral] xref: LINCS:LSM-5875 xref: VSDB:1773 is_a: CHEBI:35618 ! aromatic ether [Term] id: CHEBI:9587 name: ticarcillin namespace: chebi_ontology def: "A penicillin compound having a 6beta-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group." [] subset: 3_STAR synonym: "(2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [IUPAC] synonym: "alpha-carboxy-3-thienylmethylpenicillin" RELATED [Patent] xref: DrugBank:DB01607 xref: KEGG:C07139 xref: KEGG:D08593 xref: Patent:BE646991 xref: Patent:US3282926 xref: Wikipedia:Ticarcillin is_a: CHEBI:88187 ! penicillin allergen relationship: is_conjugate_acid_of CHEBI:51811 ! ticarcillin(2-) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CHEBI:9665 name: triadimefon namespace: chebi_ontology def: "A racemate comprising equal amounts of (R)- and (S)-triadimefon. A fungicide used to control powdery mildew, rusts and other infections in crops." [] subset: 3_STAR synonym: "(+-)-triadimefon" RELATED [ChEBI] synonym: "(RS)-triadimefon" RELATED [ChEBI] synonym: "1-(1,2,4-Triazoyl-1)-1-(4-chloro-phenoxy)-3,3-dimethylbutanone" RELATED [ChemIDplus] synonym: "1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one" RELATED [ChemIDplus] synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butanone" RELATED [NIST_Chemistry_WebBook] synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone" RELATED [Alan_Wood's_Pesticides] synonym: "rac-triadimefon" RELATED [ChEBI] synonym: "racemic triadimefon" RELATED [ChEBI] synonym: "triadimefone" RELATED [MetaCyc] xref: KEGG:C11156 xref: MetaCyc:CPD-4061 xref: Wikipedia:Triadimefon is_a: CHEBI:60911 ! racemate is_a: CHEBI:87067 ! conazole fungicide is_a: CHEBI:87100 ! triazole fungicide relationship: BFO:0000051 CHEBI:84003 ! has part (R)-triadimefon relationship: BFO:0000051 CHEBI:84004 ! has part (S)-triadimefon relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:9700 name: tridemorph namespace: chebi_ontology def: "A mixture of 4-alkyl-2,6-dimethylmorpholines, where 'alkyl' is a mixture of C11 to C14 homologues of which 60-70% is tridecyl. A systemic fungicide, it is no longer approved for use within the European Union." [] subset: 3_STAR synonym: "BAS 2203F" RELATED [ChemIDplus] synonym: "Tridemorph" EXACT [KEGG_COMPOUND] synonym: "tridemorphe" RELATED [ChEBI] xref: HMDB:HMDB0031810 xref: KEGG:C11285 xref: Patent:BE614214 xref: Patent:US3468885 xref: Wikipedia:Tridemorph is_a: CHEBI:60004 ! mixture is_a: CHEBI:87134 ! morpholine fungicide relationship: BFO:0000051 CHEBI:83297 ! has part 4-dodecyl-2,6-dimethylmorpholine relationship: BFO:0000051 CHEBI:83365 ! has part 2,6-dimethyl-4-tridecylmorpholine relationship: BFO:0000051 CHEBI:83368 ! has part 2,6-dimethyl-4-undecylmorpholine relationship: BFO:0000051 CHEBI:83370 ! has part 2,6-dimethyl-4-tetradecylmorpholine relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:9763 name: trovafloxacin namespace: chebi_ontology def: "A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure." [] subset: 3_STAR xref: DrugBank:DB00685 xref: HMDB:HMDB0014823 xref: KEGG:C07664 xref: KEGG:D08654 xref: Wikipedia:Trovafloxacin is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:33709 ! amino acid is_a: CHEBI:38295 ! azabicycloalkane is_a: CHEBI:38582 ! difluorobenzene is_a: CHEBI:50994 ! primary amino compound is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:73537 ! 1,8-naphthyridine derivative is_a: CHEBI:86324 ! quinolone antibiotic is_a: CHEBI:87211 ! fluoroquinolone antibiotic relationship: is_conjugate_base_of CHEBI:77569 ! trovafloxacin(1+) relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor [Term] id: CHEBI:9948 name: verapamil namespace: chebi_ontology def: "A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine." [] subset: 3_STAR synonym: "Verapamil" EXACT [KEGG_COMPOUND] xref: DrugBank:DB00661 xref: HMDB:HMDB0001850 xref: KEGG:C07188 xref: KEGG:D02356 xref: Wikipedia:Verapamil is_a: CHEBI:60911 ! racemate relationship: BFO:0000051 CHEBI:77734 ! has part dexverapamil relationship: BFO:0000051 CHEBI:77736 ! has part (S)-verapamil relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent relationship: RO:0000087 CHEBI:35674 ! has role antihypertensive agent relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic relationship: RO:0000087 CHEBI:38070 ! has role anti-arrhythmia drug relationship: RO:0000087 CHEBI:38215 ! has role calcium channel blocker relationship: RO:0000087 CHEBI:62872 ! has role EC 1.2.3.1 (aldehyde oxidase) inhibitor relationship: RO:0000087 CHEBI:77255 ! has role EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor relationship: RO:0000087 CHEBI:77745 ! has role EC 3.4.24.18 (meprin A) inhibitor relationship: RO:0000087 CHEBI:77747 ! has role EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant [Term] id: CHEBI:9986 name: vinclozolin namespace: chebi_ontology def: "A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp." [] subset: 3_STAR synonym: "(+-)-vinclozolin" RELATED [ChEBI] synonym: "(RS)-vinclozolin" RELATED [ChEBI] synonym: "3-(3,5-Dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" RELATED [ChemIDplus] synonym: "3-(3,5-Dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione" RELATED [ChemIDplus] synonym: "N-3,5-Dichlorophenyl-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione" RELATED [NIST_Chemistry_WebBook] synonym: "rac-vinclozolin" RELATED [ChEBI] synonym: "racemic vinclozolin" RELATED [ChEBI] synonym: "Vinchlozoline" RELATED [ChemIDplus] synonym: "Vinclozoline" RELATED [ChemIDplus] xref: KEGG:C10981 xref: Wikipedia:Vinclozolin is_a: CHEBI:60911 ! racemate is_a: CHEBI:87197 ! dichlorophenyl dicarboximide fungicide relationship: BFO:0000051 CHEBI:83733 ! has part (R)-vinclozolin relationship: BFO:0000051 CHEBI:83735 ! has part (S)-vinclozolin relationship: RO:0000087 CHEBI:35497 ! has role androgen antagonist relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical [Term] id: CHEBI:9997 name: pristinamycin IIA namespace: chebi_ontology alt_id: CHEBI:46395 def: "A macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus." [] subset: 3_STAR synonym: "Mikamycin A" RELATED [KEGG_COMPOUND] synonym: "Ostreogrycin a" RELATED [ChemIDplus] synonym: "Streptogramin A" RELATED [KEGG_COMPOUND] synonym: "Virginiamycin factor M1" RELATED [ChemIDplus] synonym: "Virginiamycin M1" RELATED [KEGG_COMPOUND] xref: DrugBank:DB01669 xref: KEGG:C11299 xref: PDBeChem:VIR xref: Wikipedia:Pristinamycin_IIA is_a: CHEBI:140325 ! secondary carboxamide is_a: CHEBI:140326 ! tertiary carboxamide is_a: CHEBI:23763 ! pyrroline is_a: CHEBI:24995 ! lactam is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:46812 ! 1,3-oxazoles is_a: CHEBI:51751 ! enamide relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug [Term] id: CL:0000000 name: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: cellxgene_subset subset: human_subset subset: mouse_subset subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: MESH:D002477 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle disjoint_from: GO:0044423 ! virion component relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: CL:0000005 name: neural crest derived fibroblast def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset synonym: "fibroblast neural crest derived" EXACT [] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell (metazoa) def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0000008 name: migratory cranial neural crest cell def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091] subset: human_subset subset: mouse_subset is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000011 name: migratory trunk neural crest cell def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095] subset: human_subset subset: mouse_subset is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000014 name: germ line stem cell def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016] subset: human_subset subset: mouse_subset synonym: "germline stem cell" EXACT [] is_a: CL:0000034 ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000021 name: female germ cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis relationship: RO:0002215 GO:0048477 ! capable of oogenesis [Term] id: CL:0000022 name: female germ line stem cell def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016] subset: human_subset subset: mouse_subset is_a: CL:0000014 ! germ line stem cell is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000023 name: oocyte def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FMA:18644 xref: MESH:D009865 xref: WBbt:0006797 is_a: CL:0000021 ! female germ cell relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division [Term] id: CL:0000024 name: oogonial cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83673 is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0000278 ! capable of mitotic cell cycle relationship: RO:0002202 CL:0000670 ! develops from primordial germ cell relationship: RO:0002215 GO:0000278 ! capable of mitotic cell cycle [Term] id: CL:0000025 name: egg cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FMA:67343 xref: MESH:D010063 is_a: CL:0000675 ! female gamete relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division relationship: RO:0002202 CL:0000023 ! develops from oocyte [Term] id: CL:0000027 name: smooth muscle cell neural crest derived def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] subset: human_subset subset: mouse_subset is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000029 name: neural crest derived neuron def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuron neural crest derived" EXACT [] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0002676 ! develops from neural crest derived neuroblast [Term] id: CL:0000030 name: glioblast def: "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes." [PMID:37824650, Wikipedia:Glioblast] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuroblast" EXACT [] xref: BTO:0000930 xref: FMA:70563 is_a: CL:0011026 ! progenitor cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000034 name: stem cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "animal stem cell" EXACT [] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000035 name: single fate stem cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001400 ! bearer of unipotent intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0000053 PATO:0001400 ! bearer of unipotent [Term] id: CL:0000036 name: epithelial fate stem cell def: "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues." [doi:/10.1038/sj.eye.6700575, PMID:17289566] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial stem cell" EXACT [] is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: RO:0002215 GO:0030855 ! capable of epithelial cell differentiation relationship: RO:0002215 GO:0030855 ! capable of epithelial cell differentiation [Term] id: CL:0000037 name: hematopoietic stem cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:86475 xref: MESH:D006412 xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0000566 ! develops from angioblastic mesenchymal cell relationship: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation [Term] id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset subset: ubprop:upper_level is_a: CL:0000000 ! cell relationship: RO:0002215 GO:0022414 ! capable of reproductive process [Term] id: CL:0000040 name: monoblast def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. subset: human_subset subset: mouse_subset synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: CALOHA:TS-1195 xref: FMA:83553 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0000791 ! has part euchromatin relationship: BFO:0000051 GO:0005730 ! has part nucleolus relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002202 CL:0002009 ! develops from macrophage dendritic cell progenitor [Term] id: CL:0000047 name: neural stem cell def: "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." [PMID:30639325] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuronal stem cell" EXACT [PMID:16305818] synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell [Term] id: CL:0000048 name: multi fate stem cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] subset: human_subset subset: mouse_subset synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001402 ! bearer of multipotent intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0000053 PATO:0001402 ! bearer of multipotent [Term] id: CL:0000049 name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation intersection_of: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation [Term] id: CL:0000051 name: common lymphoid progenitor def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation [Term] id: CL:0000052 name: totipotent stem cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 xref: MESH:D039901 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000056 name: myoblast def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: NCIT:C12482 xref: VHOG:0001482 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000058 name: chondroblast def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0002320 ! connective tissue cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0007009 ! develops from prechondroblast relationship: RO:0003000 UBERON:0002418 ! produces cartilage tissue [Term] id: CL:0000064 name: ciliated cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium relationship: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000065 name: ependymal cell def: "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile." [doi:/10.3389/fncel.2021.703951, GOC:tfm, https://www.britannica.com/science/ependymal-cell, JB:jb, PMID:34335193, PMID:37008045, PMID:9550134] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "ependymocyte" NARROW [doi:10.53347/rID-51713] xref: BTO:0001724 xref: FMA:70550 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000125 ! glial cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004670 ! part of ependyma relationship: BFO:0000050 UBERON:0004670 ! part of ependyma relationship: RO:0002207 CL:0000681 ! directly develops from radial glial cell [Term] id: CL:0000066 name: epithelial cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000738 ! leukocyte relationship: BFO:0000050 UBERON:0000483 ! part of epithelium [Term] id: CL:0000067 name: ciliated epithelial cell def: "An epithelial cell that has a cilia." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000068 name: duct epithelial cell def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000058 ! part of duct relationship: BFO:0000050 UBERON:0000058 ! part of duct [Term] id: CL:0000069 name: branched duct epithelial cell subset: human_subset subset: mouse_subset is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000071 name: blood vessel endothelial cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0004638 ! part of blood vessel endothelium [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000076 name: squamous epithelial cell subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell def: "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." [GOC:tfm, ISBN:0721662544, PMID:26106328] comment: Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. {xref="PMID:26106328"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0001136 ! part of mesothelium [Term] id: CL:0000078 name: peridermal cell def: "Any squamous epithelial cell that is part of some periderm." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000362 ! epidermal cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0003055 ! part of periderm relationship: BFO:0000050 UBERON:0003055 ! part of periderm [Term] id: CL:0000080 name: circulating cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid relationship: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid [Term] id: CL:0000081 name: blood cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:62844 xref: MESH:D001773 is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation relationship: RO:0002215 GO:0008015 ! capable of blood circulation [Term] id: CL:0000082 name: epithelial cell of lung def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium relationship: BFO:0000050 UBERON:0000115 ! part of lung epithelium [Term] id: CL:0000084 name: T cell def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: MESH:D013601 xref: VHOG:0001479 is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 ! capable of T cell mediated immunity relationship: RO:0002202 CL:0000827 ! develops from pro-T cell relationship: RO:0002215 GO:0002456 ! capable of T cell mediated immunity [Term] id: CL:0000092 name: osteoclast def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 xref: MESH:D010010 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0001035 ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element intersection_of: BFO:0000051 PR:000001850 ! has part cathepsin K intersection_of: BFO:0000051 PR:000001937 ! has part tartrate-resistant acid phosphatase type 5 intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000007597 ! has part protein c-Fos intersection_of: BFO:0000051 PR:000011178 ! has part nuclear factor NF-kappa-B p100 subunit intersection_of: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0002215 GO:0045453 ! capable of bone resorption relationship: BFO:0000051 PR:000001850 ! has part cathepsin K relationship: BFO:0000051 PR:000001937 ! has part tartrate-resistant acid phosphatase type 5 relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000007597 ! has part protein c-Fos relationship: BFO:0000051 PR:000011178 ! has part nuclear factor NF-kappa-B p100 subunit relationship: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0000576 ! develops from monocyte relationship: RO:0002215 GO:0045453 ! capable of bone resorption [Term] id: CL:0000094 name: granulocyte def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: BFO:0000051 GO:0030141 ! has part secretory granule intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8 intersection_of: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation relationship: BFO:0000051 GO:0030141 ! has part secretory granule relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8 relationship: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor [Term] id: CL:0000095 name: neuron associated cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell [Term] id: CL:0000098 name: sensory epithelial cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). subset: human_subset subset: mouse_subset synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception [Term] id: CL:0000099 name: interneuron def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CNS interneuron" RELATED [] xref: BTO:0003811 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:2000029 ! central nervous system neuron relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0000100 name: motor neuron def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000101 name: sensory neuron def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001037 xref: FMA:84649 xref: MESH:D011984 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception [Term] id: CL:0000107 name: autonomic neuron def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system relationship: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system [Term] id: CL:0000108 name: cholinergic neuron def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004902 xref: FMA:84796 xref: MESH:D059329 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission relationship: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission [Term] id: CL:0000113 name: mononuclear phagocyte def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001433 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate [Term] id: CL:0000114 name: surface ectodermal cell def: "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." [doi:/10.1101/2024.07.02.601324, PMID:7892198, Wikipedia:Surface_ectoderm] subset: human_subset subset: mouse_subset synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [doi:/10.1101/2024.07.02.601324] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell intersection_of: CL:0000221 ! ectodermal cell intersection_of: BFO:0000050 UBERON:0000076 ! part of external ectoderm relationship: BFO:0000050 UBERON:0000076 ! part of external ectoderm [Term] id: CL:0000115 name: endothelial cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell [Term] id: CL:0000118 name: basket cell def: "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." [WikipediaVersioned:Basket_cell&oldid=951703880] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0011005 ! GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070002 ! bearer of basket cell morphology intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0000053 PATO:0070002 ! bearer of basket cell morphology [Term] id: CL:0000119 name: cerebellar Golgi cell def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [NIFSTD:sao1415726815] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebellar Golgi neuron" EXACT [] synonym: "cerebellum Golgi cell" EXACT [] synonym: "Golgi cell" EXACT [] synonym: "Golgi neuron" EXACT [] xref: MESH:D000080906 is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron relationship: RO:0002100 UBERON:0002956 ! has soma location granular layer of cerebellar cortex relationship: RO:0002113 UBERON:0002956 ! has presynaptic terminal in granular layer of cerebellar cortex relationship: RO:0002360 UBERON:0002974 ! has dendrite location molecular layer of cerebellar cortex [Term] id: CL:0000120 name: granule cell def: "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." [https://medical-dictionary.thefreedictionary.com/granule+cell] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003393 is_a: CL:2000029 ! central nervous system neuron [Term] id: CL:0000121 name: Purkinje cell def: "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress." [MESH:D011689, PMID:12907269, PMID:14568361, PMID:31424738, PMID:33288911, PMID:38168772] comment: Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024). {xref="PMID:27215193", xref="PMID:17535929", xref="PMID:37426070", xref="https://doi.org/10.1016/j.stem.2023.11.013"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebellar Purkinje cell" EXACT [https://doi.org/10.1016/j.proghi.2004.07.002] synonym: "Purkinje neuron" EXACT [PMID:28821816] xref: BTO:0001011 xref: CALOHA:TS-0845 xref: FMA:67969 is_a: CL:0000617 ! GABAergic neuron is_a: CL:1001611 ! cerebellar neuron relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex [Term] id: CL:0000122 name: stellate neuron def: "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." [ISBN:9780123973481] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0002316 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0000053 PATO:0070010 ! bearer of stellate morphology relationship: RO:0000053 PATO:0070010 ! bearer of stellate morphology [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000095 ! neuron associated cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000125 name: glial cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000126 name: macroglial cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "macrogliocyte" EXACT [] xref: BTO:0000771 xref: CALOHA:TS-2027 xref: FMA:54538 is_a: CL:0000125 ! glial cell relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "astrocytic glia" EXACT [] xref: BTO:0000099 xref: CALOHA:TS-0060 xref: FMA:54537 is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:D009836] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [PMID:8734446] xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 is_a: CL:0000126 ! macroglial cell is_a: CL:4023154 ! myelinating glial cell relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002202 CL:0002453 ! develops from oligodendrocyte precursor cell [Term] id: CL:0000129 name: microglial cell def: "A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] comment: Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. {xref="PMID:23616747"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/] synonym: "MF.microglia.CNS" RELATED [] synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 is_a: CL:0000125 ! glial cell is_a: CL:0000878 ! central nervous system macrophage intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002215 GO:0045087 ! capable of innate immune response [Term] id: CL:0000131 name: gut endothelial cell def: "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream." [PMID:26564856] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: RO:0002202 CL:0000223 ! develops from endodermal cell [Term] id: CL:0000133 name: neurectodermal cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "bone marrow stromal cells" NARROW [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000136 name: adipocyte def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "adipose cell" EXACT [] synonym: "fat cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell [Term] id: CL:0000138 name: chondrocyte def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: RO:0001025 UBERON:0002418 ! located in cartilage tissue relationship: RO:0002202 CL:0000058 ! develops from chondroblast [Term] id: CL:0000145 name: professional antigen presenting cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: CL:0000147 name: pigment cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000149 name: visual pigment cell subset: human_subset subset: mouse_subset synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular secretory epithelial cell def: "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." [GOC:tfm, ORCID:0000-0002-7073-9172] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "glandular epithelial cell" EXACT [] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002530 ! part of gland relationship: BFO:0000050 UBERON:0002530 ! part of gland [Term] id: CL:0000151 name: secretory cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell relationship: RO:0002215 GO:0032940 ! capable of secretion by cell [Term] id: CL:0000152 name: exocrine cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:16014 is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "GAG secreting cell" EXACT [] synonym: "hyaluronic acid secreting cell" NARROW [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 ! capable of protein secretion relationship: RO:0002215 GO:0009306 ! capable of protein secretion [Term] id: CL:0000159 name: seromucus secreting cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell [Term] id: CL:0000163 name: endocrine cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system [Term] id: CL:0000165 name: neuroendocrine cell def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099] comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neurosecretory cell" RELATED [] synonym: "neurosecretory neuron" RELATED [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0046879 ! capable of hormone secretion [Term] id: CL:0000166 name: chromaffin cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:D019439] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 is_a: CL:0000029 ! neural crest derived neuron is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell [Term] id: CL:0000167 name: peptide hormone secreting cell def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 ! capable of peptide hormone secretion relationship: RO:0002215 GO:0030072 ! capable of peptide hormone secretion [Term] id: CL:0000174 name: steroid hormone secreting cell def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 ! capable of steroid hormone secretion relationship: RO:0002215 GO:0035929 ! capable of steroid hormone secretion [Term] id: CL:0000183 name: contractile cell def: "A cell whose primary function is to shorten." [FB:ma] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell [Term] id: CL:0000187 name: muscle cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000393 ! electrically responsive cell relationship: RO:0002202 CL:0000056 ! develops from myoblast [Term] id: CL:0000188 name: cell of skeletal muscle def: "A somatic cell located in skeletal muscle." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue [Term] id: CL:0000192 name: smooth muscle cell def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" BROAD [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: RO:0002202 CL:0000514 ! develops from smooth muscle myoblast [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] subset: human_subset subset: mouse_subset synonym: "receptor cell" EXACT [] xref: MESH:D011984 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: BFO:0000050 UBERON:0001032 ! part of sensory system relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception [Term] id: CL:0000206 name: chemoreceptor cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] subset: human_subset subset: mouse_subset is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception relationship: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception [Term] id: CL:0000209 name: taste receptor cell def: "A specialized cell involved in gustatory sensory perception." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "taste bud cell" EXACT [] xref: FMA:67910 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000206 ! chemoreceptor cell intersection_of: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste relationship: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste [Term] id: CL:0000210 name: photoreceptor cell def: "A cell specialized in detecting light stimuli that are involved in visual perception." [MESH:D010786] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FMA:86740 is_a: CL:0000101 ! sensory neuron is_a: CL:0008028 ! visual system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception relationship: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception [Term] id: CL:0000211 name: electrically active cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] subset: human_subset subset: mouse_subset synonym: "synoviocyte" EXACT [] xref: CALOHA:TS-0995 is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint [Term] id: CL:0000218 name: myelinating Schwann cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:D012583] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 is_a: CL:0002573 ! Schwann cell is_a: CL:4023154 ! myelinating glial cell relationship: RO:0002202 CL:0002377 ! develops from immature Schwann cell [Term] id: CL:0000219 name: motile cell def: "A cell that moves by its own activities." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0048870 ! capable of cell motility relationship: RO:0002215 GO:0048870 ! capable of cell motility [Term] id: CL:0000221 name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: CL:0000222 name: mesodermal cell def: "A cell of the middle germ layer of the embryo." [MESH:D008648] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm [Term] id: CL:0000223 name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] subset: human_subset subset: mouse_subset synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000925 ! part of endoderm [Term] id: CL:0000225 name: anucleate cell def: "A cell that lacks a nucleus." [FB:ma] synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001405 ! bearer of anucleate relationship: RO:0000053 PATO:0001405 ! bearer of anucleate [Term] id: CL:0000226 name: single nucleate cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate relationship: RO:0000053 PATO:0001407 ! bearer of mononucleate [Term] id: CL:0000228 name: multinucleate cell def: "A cell with more than one nucleus." [FB:ma, Wikipedia:Multinucleate] subset: human_subset subset: mouse_subset synonym: "multinucleated cells" EXACT [Wikipedia:Multinucleate] synonym: "polynuclear cells" EXACT [Wikipedia:Multinucleate] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate relationship: RO:0000053 PATO:0001908 ! bearer of multinucleate [Term] id: CL:0000232 name: erythrocyte def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: RO:0000053 PATO:0002039 ! bearer of biconcave intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport relationship: CL:4030045 GO:0005840 ! lacks_part ribosome relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: RO:0000053 PATO:0002039 ! bearer of biconcave relationship: RO:0002202 CL:0000558 ! develops from reticulocyte [Term] id: CL:0000234 name: phagocyte def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001044 xref: FMA:83806 xref: MESH:D010586 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis relationship: RO:0002215 GO:0006909 ! capable of phagocytosis [Term] id: CL:0000235 name: macrophage def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 xref: MESH:D008264 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0031268 ! capable of pseudopodium organization relationship: RO:0002202 CL:0000576 ! develops from monocyte relationship: RO:0002215 GO:0031268 ! capable of pseudopodium organization [Term] id: CL:0000239 name: brush border epithelial cell def: "An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption." [] comment: All brush border cells are columnar-cuboidal. The formal logical definition of this term asserts this. Brush border epithelial cells are predominantly found lining the small intestine and the proximal tubules of the kidneys. subset: human_subset subset: mouse_subset xref: https://doi.org/10.1152/ajpgi.00005.2011 xref: PMID:25422372 is_a: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000051 GO:0005903 ! has part brush border relationship: BFO:0000051 GO:0005903 ! has part brush border [Term] id: CL:0000255 name: eukaryotic cell def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: CL:0000287 name: eye photoreceptor cell def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0000970 ! part of eye [Term] id: CL:0000295 name: somatotropin secreting cell def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030252 ! capable of growth hormone secretion relationship: RO:0002215 GO:0030252 ! capable of growth hormone secretion [Term] id: CL:0000300 name: gamete def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0000053 PATO:0001375 ! bearer of haploid intersection_of: RO:0002215 GO:0009566 ! capable of fertilization relationship: RO:0002215 GO:0009566 ! capable of fertilization [Term] id: CL:0000306 name: crystallin accumulating cell subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "lens cell" EXACT [] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell def: "An epithelial cell found in the trachea." [GOC:tfm] comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' subset: human_subset subset: mouse_subset synonym: "tracheocyte" EXACT [] xref: FMA:74793 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 CL:0000377 ! develops from tracheoblast [Term] id: CL:0000313 name: serous secreting cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000325 name: stuff accumulating cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: human_subset subset: mouse_subset subset: ubprop:upper_level is_a: CL:0000000 ! cell [Term] id: CL:0000327 name: extracellular matrix secreting cell subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000499 ! stromal cell [Term] id: CL:0000329 name: oxygen accumulating cell def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport relationship: RO:0002215 GO:0015671 ! capable of oxygen transport [Term] id: CL:0000333 name: migratory neural crest cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] subset: human_subset subset: mouse_subset xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0007004 ! develops from premigratory neural crest cell [Term] id: CL:0000335 name: mesenchyme condensation cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] subset: human_subset subset: mouse_subset is_a: CL:0008019 ! mesenchymal cell [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset synonym: "spongioblast" EXACT [] xref: FMA:70564 is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) [Term] id: CL:0000347 name: scleral cell def: "A cell of the sclera of the eye." [GOC:add] subset: eye_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera relationship: BFO:0000050 UBERON:0001773 ! part of sclera relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000348 name: choroidal cell of the eye def: "A cell that is part of optic choroid." [GOC:add] subset: eye_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell [Term] id: CL:0000349 name: extraembryonic cell def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure [Term] id: CL:0000351 name: trophoblast cell def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [doi:10.1007/978-3-030-84725-8, GOC:tfm, MESH:D014327, PMID:37630754] subset: human_subset subset: mouse_subset synonym: "trophoblastic cell" EXACT [doi:10.1007/978-3-030-84725-8] xref: FMA:83028 is_a: CL:0000349 ! extraembryonic cell relationship: RO:0002202 CL:1000274 ! develops from trophectodermal cell [Term] id: CL:0000352 name: epiblast cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] subset: human_subset subset: mouse_subset synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell (metazoa) [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. subset: human_subset subset: mouse_subset xref: FMA:86767 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue [Term] id: CL:0000359 name: vascular associated smooth muscle cell def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002049 ! part of vasculature relationship: BFO:0000050 UBERON:0002049 ! part of vasculature [Term] id: CL:0000362 name: epidermal cell def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 xref: MESH:D000078404 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0007376 ! part of outer epithelium relationship: BFO:0000050 UBERON:0007376 ! part of outer epithelium [Term] id: CL:0000365 name: animal zygote def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] subset: human_subset subset: mouse_subset synonym: "zygote" BROAD [] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote intersection_of: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: CL:0000377 name: tracheoblast subset: human_subset subset: mouse_subset is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000388 name: tendon cell def: "An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:37894875, PMID:957445] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] is_a: CL:1000307 ! fibroblast of dense regular elastic tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000043 ! part of tendon relationship: BFO:0000050 UBERON:0000043 ! part of tendon [Term] id: CL:0000393 name: electrically responsive cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000397 name: ganglion interneuron def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 ! has soma location ganglion relationship: RO:0002100 UBERON:0000045 ! has soma location ganglion [Term] id: CL:0000404 name: electrically signaling cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] subset: human_subset subset: mouse_subset is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000413 name: haploid cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001375 ! bearer of haploid relationship: RO:0000053 PATO:0001375 ! bearer of haploid [Term] id: CL:0000438 name: luteinizing hormone secreting cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0032275 ! capable of luteinizing hormone secretion relationship: RO:0002215 GO:0032275 ! capable of luteinizing hormone secretion [Term] id: CL:0000439 name: prolactin secreting cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] subset: human_subset subset: mouse_subset is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070459 ! capable of prolactin secretion relationship: RO:0002215 GO:0070459 ! capable of prolactin secretion [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone secretion relationship: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone secretion [Term] id: CL:0000447 name: carbohydrate secreting cell subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell [Term] id: CL:0000451 name: dendritic cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 xref: MESH:D003713 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 GO:0042613 ! has part MHC class II protein complex intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation intersection_of: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation disjoint_from: CL:0000542 ! lymphocyte relationship: BFO:0000051 GO:0042613 ! has part MHC class II protein complex relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation [Term] id: CL:0000457 name: biogenic amine secreting cell subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell [Term] id: CL:0000458 name: serotonin secreting cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] subset: human_subset subset: mouse_subset synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 ! capable of serotonin secretion relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "noradrenaline secreting cell" EXACT [] synonym: "norepinephrin secreting cell" EXACT [] synonym: "norepinephrine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 ! capable of norepinephrine secretion relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "ACTH secreting cell" EXACT [GO:0051458] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [GO:0051458] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0051458 ! capable of corticotropin secretion relationship: RO:0002215 GO:0051458 ! capable of corticotropin secretion [Term] id: CL:0000488 name: visible light photoreceptor cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009584 ! capable of detection of visible light relationship: RO:0002215 GO:0009584 ! capable of detection of visible light [Term] id: CL:0000498 name: inhibitory interneuron def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:84776 is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell def: "A connective tissue cell of an organ found in the loose connective tissue." [GOC:tfm, MESH:D017154] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0002064 xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell [Term] id: CL:0000513 name: cardiac muscle myoblast def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast intersection_of: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell relationship: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000192 ! develops into smooth muscle cell relationship: RO:0002203 CL:0000192 ! develops into smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber relationship: RO:0002202 CL:0000355 ! develops from multi-potent skeletal muscle stem cell relationship: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000234 ! phagocyte is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000521 name: fungal cell def: "Any cell that in taxon some Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002162 NCBITaxon:4751 ! in taxon Fungi relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi [Term] id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "plasmidotrophoblast cell" RELATED [] synonym: "syncytial trophoblast cell" EXACT [PMID:11787150] synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368] synonym: "syntrophoblast cell" RELATED [] xref: FMA:83043 is_a: CL:0000351 ! trophoblast cell is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate relationship: BFO:0000050 UBERON:0000371 ! part of syncytiotrophoblast [Term] id: CL:0000526 name: afferent neuron def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000540 ! neuron [Term] id: CL:0000527 name: efferent neuron def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000540 name: neuron def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: RO:0002202 CL:0000031 {gci_filler="NCBITaxon:7742", gci_relation="RO:0002162", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! develops from neuroblast (sensu Vertebrata) relationship: RO:0002215 GO:0019226 ! capable of transmission of nerve impulse [Term] id: CL:0000542 name: lymphocyte def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: MESH:D008214 xref: VHOG:0001535 is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate intersection_of: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio disjoint_from: CL:0000766 ! myeloid leukocyte relationship: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor [Term] id: CL:0000547 name: proerythroblast def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated intersection_of: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0005730 ! has part nucleolus relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002202 CL:0000038 ! develops from erythroid progenitor cell [Term] id: CL:0000549 name: basophilic erythroblast def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 [Term] id: CL:0000550 name: polychromatophilic erythroblast def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002202 CL:0000549 ! develops from basophilic erythroblast [Term] id: CL:0000552 name: orthochromatic erythroblast def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm intersection_of: RO:0000056 GO:0030263 ! participates in apoptotic chromosome condensation relationship: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm relationship: RO:0000056 GO:0030263 ! participates in apoptotic chromosome condensation relationship: RO:0002202 CL:0000550 ! develops from polychromatophilic erythroblast [Term] id: CL:0000553 name: megakaryocyte progenitor cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle intersection_of: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation [Term] id: CL:0000556 name: megakaryocyte def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: RO:0000053 PATO:0001393 ! bearer of euploid relationship: RO:0002202 CL:0000553 ! develops from megakaryocyte progenitor cell [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor intersection_of: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0030225 ! capable of macrophage differentiation intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor relationship: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2 relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation [Term] id: CL:0000558 name: reticulocyte def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001173 xref: CALOHA:TS-0864 xref: MESH:D012156 is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 intersection_of: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002202 CL:0000552 ! develops from orthochromatic erythroblast relationship: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly [Term] id: CL:0000559 name: promonocyte def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004657 xref: FMA:83551 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002202 CL:0000040 ! develops from monoblast [Term] id: CL:0000562 name: nucleate erythrocyte def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] subset: human_subset subset: mouse_subset synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated relationship: RO:0002202 CL:0002421 ! develops from nucleated reticulocyte [Term] id: CL:0000566 name: angioblastic mesenchymal cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. subset: human_subset subset: mouse_subset synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1 relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1 relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell [Term] id: CL:0000568 name: amine precursor uptake and decarboxylation cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset synonym: "APUD cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 xref: MESH:D001078 is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: RO:0002203 CL:0002494 ! develops into cardiocyte relationship: RO:0002203 CL:0002494 ! develops into cardiocyte [Term] id: CL:0000573 name: retinal cone cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! develops from retinal progenitor cell [Term] id: CL:0000575 name: corneal epithelial cell def: "An epithelial cell of the cornea." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0001772 ! part of corneal epithelium relationship: BFO:0000050 UBERON:0001772 ! part of corneal epithelium [Term] id: CL:0000576 name: monocyte def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate intersection_of: RO:0002215 GO:0030225 ! capable of macrophage differentiation intersection_of: RO:0002215 GO:0030316 ! capable of osteoclast differentiation intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation relationship: RO:0002202 CL:0000559 ! develops from promonocyte relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030316 ! capable of osteoclast differentiation relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation [Term] id: CL:0000586 name: germ cell def: "The reproductive cell in multicellular organisms." [MESH:D005854] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000535 xref: NCIT:C12597 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 ! germ line cell relationship: RO:0002216 GO:0009566 ! capable of part of fertilization [Term] id: CL:0000593 name: androgen secreting cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 ! capable of androgen secretion relationship: RO:0002215 GO:0035935 ! capable of androgen secretion [Term] id: CL:0000596 name: sexual spore def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000604 name: retinal rod cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! develops from retinal progenitor cell [Term] id: CL:0000605 name: fungal asexual spore def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000617 name: GABAergic neuron def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 xref: MESH:D059330 xref: WBbt:0005190 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0000622 name: acinar cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 xref: MESH:D061354 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000154 ! protein secreting cell intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: CL:0000154 ! protein secreting cell intersection_of: BFO:0000050 UBERON:0009842 ! part of glandular acinus relationship: BFO:0000050 UBERON:0009842 ! part of glandular acinus [Term] id: CL:0000630 name: supporting cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "supportive cell" EXACT [] xref: BTO:0002315 is_a: CL:0000000 ! cell [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256] subset: human_subset subset: mouse_subset xref: FMA:83089 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0012001 ! neuron of the forebrain is_a: CL:2000004 ! pituitary gland cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002196 ! part of adenohypophysis relationship: BFO:0000050 UBERON:0002196 ! part of adenohypophysis [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland relationship: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis [Term] id: CL:0000642 name: folliculostellate cell def: "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." [doi:10.23937/2572-407X.1510006, JB:jb, PMID:10495875, PMID:15961560] comment: Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets. {xref="doi:10.23937/2572-407X.1510006", xref="PMID:34734454", xref="PMID:31620083", xref="PMID:18287078"} subset: human_subset subset: mouse_subset synonym: "folliculo-stellate cell" EXACT [doi:10.23937/2572-407X.1510006] synonym: "pituitary folliculostellate cell" EXACT [PMID:34734454] synonym: "Sox2-positive stem cell" RELATED [PMID:34734454] is_a: CL:0000630 ! supporting cell is_a: CL:2000004 ! pituitary gland cell relationship: BFO:0000050 UBERON:0002196 ! part of adenohypophysis [Term] id: CL:0000644 name: Bergmann glial cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 is_a: CL:0002603 ! astrocyte of the cerebellum relationship: BFO:0000050 UBERON:0002979 ! part of Purkinje cell layer of cerebellar cortex [Term] id: CL:0000652 name: pinealocyte def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001068 xref: FMA:83417 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0001905 ! part of pineal body relationship: RO:0002215 GO:0030187 ! capable of melatonin biosynthetic process [Term] id: CL:0000666 name: fenestrated endothelial cell def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "window cell" EXACT [] is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: RO:0000053 PATO:0002064 ! bearer of fenestrated relationship: RO:0000053 PATO:0002064 ! bearer of fenestrated [Term] id: CL:0000667 name: collagen secreting cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000670 name: primordial germ cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 ! germ line cell is_a: CL:0000219 ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo intersection_of: RO:0002215 GO:0048870 ! capable of cell motility relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:0000675 name: female gamete def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000021 ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000679 name: glutamatergic neuron def: "A neuron that is capable of some neurotansmission by glutamate secretion." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: WBbt:0006829 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission relationship: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission [Term] id: CL:0000680 name: muscle precursor cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002203 CL:0000187 ! develops into muscle cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002203 CL:0000187 ! develops into muscle cell [Term] id: CL:0000681 name: radial glial cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "forebrain radial glial cell" NARROW [] is_a: CL:0000125 ! glial cell relationship: RO:0002202 CL:0000710 ! develops from neurecto-epithelial cell [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion [Term] id: CL:0000691 name: stellate interneuron def: "Any interneuron that has characteristic some stellate morphology." [FBC:Autogenerated] subset: BDS_subset subset: human_subset subset: mouse_subset is_a: CL:0000099 ! interneuron is_a: CL:0000122 ! stellate neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0000053 PATO:0070010 ! bearer of stellate morphology [Term] id: CL:0000706 name: choroid plexus epithelial cell def: "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF." [GOC:add, GOC:tfm, JB:jb, PMID:15561411, PMID:9550134] comment: A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions. {xref="PMID:25729351"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "choroid plexus cell" BROAD [DOI:10.1101/2022.10.12.511898] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000239 ! brush border epithelial cell intersection_of: CL:0000065 ! ependymal cell intersection_of: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium relationship: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion [Term] id: CL:0000710 name: neurecto-epithelial cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). subset: human_subset subset: mouse_subset synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: RO:0002202 CL:0000133 ! develops from neurectodermal cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell [Term] id: CL:0000723 name: somatic stem cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] subset: human_subset subset: mouse_subset xref: CALOHA:TS-2086 xref: MESH:D053687 is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division relationship: RO:0002215 GO:0048103 ! capable of somatic stem cell division [Term] id: CL:0000737 name: striated muscle cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001410 ! bearer of striated disjoint_from: CL:0008000 ! non-striated muscle cell relationship: BFO:0000051 GO:0030017 ! has part sarcomere relationship: RO:0000053 PATO:0001410 ! bearer of striated [Term] id: CL:0000738 name: leukocyte def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "immune cell" RELATED [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 xref: MESH:D007962 xref: NCIT:C12529 is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated intersection_of: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell relationship: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration [Term] id: CL:0000740 name: retinal ganglion cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] xref: BTO:0001800 xref: FMA:67765 xref: MESH:D012165 is_a: CL:0000540 ! neuron relationship: RO:0002100 UBERON:0000966 ! has soma location retina [Term] id: CL:0000746 name: cardiac muscle cell def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 xref: MESH:D032383 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0002478 ! bearer of transversely striated intersection_of: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0000053 PATO:0002478 ! bearer of transversely striated relationship: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0002202 CL:0000513 ! develops from cardiac muscle myoblast [Term] id: CL:0000763 name: myeloid cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0001441 xref: CALOHA:TS-0647 xref: MESH:D022423 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor relationship: RO:0002202 CL:0000049 ! develops from common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell [Term] id: CL:0000765 name: erythroblast def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 xref: MESH:D004900 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: BFO:0000051 GO:0005634 ! has part nucleus intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: BFO:0000051 GO:0005634 ! has part nucleus relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002202 CL:0000547 ! develops from proerythroblast relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation [Term] id: CL:0000766 name: myeloid leukocyte def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000738 ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor [Term] id: CL:0000778 name: mononuclear osteoclast def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. subset: human_subset subset: mouse_subset is_a: CL:0000092 ! osteoclast is_a: CL:0000113 ! mononuclear phagocyte intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate [Term] id: CL:0000779 name: multinuclear osteoclast def: "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:29379067, PMID:38903088, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. subset: human_subset subset: mouse_subset synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 ! osteoclast is_a: CL:0000783 ! multinucleated phagocyte is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate relationship: RO:0002202 CL:0000778 ! develops from mononuclear osteoclast [Term] id: CL:0000782 name: myeloid dendritic cell def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002202 CL:0000763 ! develops from myeloid cell relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain relationship: RO:0002202 CL:0000763 ! develops from myeloid cell [Term] id: CL:0000783 name: multinucleated phagocyte def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate [Term] id: CL:0000827 name: pro-T cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 ! capable of T cell differentiation relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor relationship: RO:0002215 GO:0030217 ! capable of T cell differentiation [Term] id: CL:0000835 name: myeloblast def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] subset: human_subset subset: mouse_subset xref: BTO:0000187 xref: FMA:83524 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin intersection_of: CL:4030045 GO:0042582 ! lacks_part azurophil granule intersection_of: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm relationship: BFO:0000051 GO:0000791 ! has part euchromatin relationship: CL:4030045 GO:0042582 ! lacks_part azurophil granule relationship: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0000053 PATO:0001402 ! bearer of multipotent intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0000053 PATO:0001402 ! bearer of multipotent relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] comment: Note that this is a class of cell types, not an identified single cell type. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lymphoid progenitor cell" BROAD [] xref: BTO:0004731 xref: CALOHA:TS-2025 xref: FMA:70338 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation relationship: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation [Term] id: CL:0000842 name: mononuclear leukocyte def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mononuclear cell" EXACT [] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate [Term] id: CL:0000850 name: serotonergic neuron def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: MESH:D059326 xref: WBbt:0006837 is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0060096 ! capable of serotonin secretion, neurotransmission relationship: RO:0002215 GO:0060096 ! capable of serotonin secretion, neurotransmission [Term] id: CL:0000860 name: classical monocyte def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0006954 ! capable of inflammatory response intersection_of: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2 relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis relationship: RO:0002215 GO:0006954 ! capable of inflammatory response relationship: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2 [Term] id: CL:0000861 name: elicited macrophage def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0000056 GO:0006954 ! participates in inflammatory response intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0000056 GO:0006954 ! participates in inflammatory response relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin relationship: RO:0002202 CL:0000860 ! develops from classical monocyte [Term] id: CL:0000862 name: suppressor macrophage def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] comment: Markers: May express: IL10, TGFbeta. subset: human_subset subset: mouse_subset is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response [Term] id: CL:0000864 name: tissue-resident macrophage def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0000479 ! part of tissue relationship: BFO:0000050 UBERON:0000479 ! part of tissue [Term] id: CL:0000878 name: central nervous system macrophage def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0002319 ! neural cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0000988 name: hematopoietic cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000000 ! cell [Term] id: CL:0000990 name: conventional dendritic cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X relationship: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative is_a: CL:0011026 ! progenitor cell union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative is_a: CL:0011026 ! progenitor cell union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin relationship: RO:0002202 CL:0002043 ! develops from CD34-positive, CD38-negative multipotent progenitor cell [Term] id: CL:0001022 name: CD115-positive monocyte def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). subset: human_subset subset: mouse_subset is_a: CL:0000576 ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0000576 ! monocyte intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0002001 ! develops from CD34-positive, CD38-positive granulocyte monocyte progenitor [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871] xref: CALOHA:TS-0448 is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III intersection_of: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1 intersection_of: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein intersection_of: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1 relationship: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein relationship: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule intersection_of: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha intersection_of: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule relationship: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha relationship: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0002043 ! develops from CD34-positive, CD38-negative multipotent progenitor cell relationship: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002202 CL:0001021 ! develops from CD34-positive, CD38-positive common lymphoid progenitor [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). subset: human_subset subset: mouse_subset synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule relationship: RO:0002202 CL:0001027 ! develops from CD7-negative lymphoid progenitor cell [Term] id: CL:0001029 name: common dendritic progenitor def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CDP" EXACT [PMID:21219184] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [PMID:21219184] is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor relationship: RO:0002202 CL:0002009 ! develops from macrophage dendritic cell progenitor relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor [Term] id: CL:0001031 name: cerebellar granule cell def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." [doi:10.12688/f1000research.15021.1, doi:10.3389/fncir.2020.611841, GOC:mah] comment: It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells. {xref="doi:10.3389/fncir.2020.611841"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "granule cell of the cerebellum" EXACT [doi:10.3389/fncir.2020.611841] xref: BTO:0004278 is_a: CL:0000120 ! granule cell is_a: CL:2000028 ! cerebellum glutamatergic neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000120 ! granule cell intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum relationship: RO:0002207 CL:0002362 ! directly develops from cerebellar granule cell precursor [Term] id: CL:0001035 name: bone cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] subset: general_cell_types_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001054 name: CD14-positive monocyte def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "monocyte" NARROW [PMID:22343568] is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. subset: human_subset subset: mouse_subset synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] is_a: CL:0000049 ! common myeloid progenitor is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002215 GO:0002573 ! capable of myeloid leukocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1 relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2 relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] subset: human_subset subset: mouse_subset is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0000053 PATO:0001401 ! bearer of oligopotent relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0001061 name: abnormal cell def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." [GOC:add, GOC:cg, GOC:wdd] comment: https://github.com/obophenotype/cell-ontology/issues/448 subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0000460 ! bearer of abnormal relationship: RO:0000053 PATO:0000460 ! bearer of abnormal [Term] id: CL:0001065 name: innate lymphoid cell def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417] subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045087 ! capable of innate immune response [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1 relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. subset: human_subset subset: mouse_subset is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: RO:0002202 CL:0001026 ! develops from CD34-positive, CD38-positive common myeloid progenitor creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. subset: human_subset subset: mouse_subset is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "MDP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1 relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1 relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5 relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002202 CL:0001029 ! develops from common dendritic progenitor creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001400 ! bearer of unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: RO:0000053 PATO:0001400 ! bearer of unipotent relationship: RO:0002202 CL:0002032 ! develops from hematopoietic oligopotent progenitor cell creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). subset: blood_and_immune_upper_slim subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0000053 PATO:0001401 ! bearer of oligopotent relationship: RO:0000053 PATO:0001401 ! bearer of oligopotent relationship: RO:0002202 CL:0000837 ! develops from hematopoietic multipotent progenitor cell creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. subset: human_subset subset: mouse_subset is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein relationship: RO:0002202 CL:0001024 ! develops from CD34-positive, CD38-negative hematopoietic stem cell creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002068 name: Purkinje myocyte def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002072 name: nodal myocyte def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002076 name: endo-epithelial cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:69075 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000223 ! develops from endodermal cell relationship: RO:0002202 CL:0000223 ! develops from endodermal cell creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:69074 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000221 ! develops from ectodermal cell relationship: RO:0002202 CL:0000221 ! develops from ectodermal cell creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000222 ! develops from mesodermal cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002085 name: tanycyte def: "A specialized elongated ventricular ependymal cell with one or more processes that extend into the brain parenchyma or associated blood vessels where they contact blood vessel endothelial cells and/or neurons. These cells are found in the ventricles and circumventricular organs of the brain. They are involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte, PMID:29351662] comment: This class includes cells that are sometimes referred to as tanycyte-like cells, located in circumventricular organs (Langlet et al., 2023) as well as tanycytes located in the ventricles. {xref="PMID:23649873"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "stretch cell" EXACT [PMID:29351662] synonym: "tanycyte-like cell" NARROW [PMID:23649873] xref: BTO:0001953 xref: FMA:54560 is_a: CL:0000065 ! ependymal cell creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte def: "A leukocyte that lacks granules." [GOC:tfm] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002092 name: bone marrow cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0004850 xref: FMA:83621 xref: MESH:D001854 is_a: CL:0001035 ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow relationship: BFO:0000050 UBERON:0002371 ! part of bone marrow creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002095 name: hilus cell of ovary def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002132 name: stromal cell of ovary def: "A stomal cell of the ovary" [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002139 name: endothelial cell of vascular tree def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002144 name: capillary endothelial cell def: "An endothelial cell found in capillaries." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0002653 ! squamous endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary relationship: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002159 name: general ecto-epithelial cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000642 ! folliculostellate cell intersection_of: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis relationship: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002191 name: granulocytopoietic cell def: "A cell involved in the formation of a granulocyte." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:83519 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002194 name: monopoietic cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83552 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium relationship: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002209 name: intermediate epitheliocyte def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002220 name: interstitial cell of pineal gland def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] subset: human_subset subset: mouse_subset xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002222 name: vertebrate lens cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] subset: eye_upper_slim subset: human_subset subset: mouse_subset xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002224 name: lens epithelial cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67559 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0001803 ! part of epithelium of lens relationship: BFO:0000050 UBERON:0001803 ! part of epithelium of lens creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002240 name: marrow fibroblast def: "A fibroblast in the bone marrow." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0010001 ! stromal cell of bone marrow intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002242 name: nucleate cell def: "A cell containing at least one nucleus." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:67513 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated relationship: RO:0000053 PATO:0002505 ! bearer of nucleated creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002246 name: peripheral blood stem cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 xref: MESH:D000072916 is_a: CL:0000037 ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000050 UBERON:0000178 ! part of blood creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] subset: human_subset subset: mouse_subset is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus def: "An epithelial cell of the lining of the esophagus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:63071 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus relationship: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002262 name: endothelial cell of sinusoid def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:63134 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003909 ! part of sinusoid relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002308 name: epithelial cell of skin gland def: "An epithelial cell of a skin gland." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002419 ! part of skin gland relationship: BFO:0000050 UBERON:0002419 ! part of skin gland creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002312 name: somatotroph def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] subset: human_subset subset: mouse_subset synonym: "somatotrope" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 xref: MESH:D052683 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002319 name: neural cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0001016 ! part of nervous system creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell def: "A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest." [GOC:tfm, ISBN:0618947256, PMID:19198652, PMID:26043871, PMID:31194383] subset: cellxgene_subset subset: general_cell_types_upper_slim subset: human_subset subset: mouse_subset xref: CALOHA:TS-2096 xref: FMA:63875 xref: MESH:D003239 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell (metazoa) def: "A cell of the embryo." [FMA:0618947256] subset: human_subset subset: mouse_subset xref: CALOHA:TS-0263 xref: FMA:82840 xref: WBbt:0007028 is_a: CL:0000000 ! cell creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002328 name: bronchial epithelial cell def: "An epithelial cell of the bronchus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002333 name: neural crest derived adipocyte def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398] subset: human_subset subset: mouse_subset is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002202 CL:0000005 ! develops from neural crest derived fibroblast creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002350 name: endocardial cell def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium relationship: BFO:0000050 UBERON:0002165 ! part of endocardium creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] subset: human_subset subset: mouse_subset is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002362 name: cerebellar granule cell precursor def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [GOC:tfm, PMID:14745007] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "granule cell precursor" BROAD [doi:10.3389/fncir.2020.611841] synonym: "granule cell progenitor" BROAD [doi:10.3389/fncir.2020.611841] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0009841 ! part of upper rhombic lip creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000005 ! neural crest derived fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002368 name: respiratory tract epithelial cell def: "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "airway epithelial cell" EXACT [] synonym: "respiratory epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] xref: MESH:D013172 is_a: CL:0000521 ! fungal cell creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002372 name: myotube def: "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myofiber" EXACT [FBbt:00005812] synonym: "myofibril" EXACT [FBbt:00005812] is_a: CL:0000737 ! striated muscle cell is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate intersection_of: RO:0000053 PATO:0002478 ! bearer of transversely striated relationship: RO:0000053 PATO:0002478 ! bearer of transversely striated creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002375 name: Schwann cell precursor def: "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." [GOC:tfm, PMID:15580626, PMID:30971890, PMID:35815410] comment: Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. {xref="PMID:35815410"} subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0011026 ! progenitor cell relationship: RO:0000053 PATO:0001402 ! bearer of multipotent relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell relationship: RO:0002387 CL:0002573 ! has potential to develop into Schwann cell creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002377 name: immature Schwann cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: RO:0002202 CL:0002375 ! develops from Schwann cell precursor creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "CD16+ monocyte" EXACT [PMID:22343568] is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2 intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III relationship: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2 relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002421 name: nucleated reticulocyte def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] subset: human_subset subset: mouse_subset is_a: CL:0000558 ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell def: "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2." [GOC:tfm, PMID:16367798, PMID:20142420, PMID:31583586, PMID:31726662, PMID:37653126] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "NG2 cell" RELATED [PMID:14501223] synonym: "Polydendrocyte" RELATED [PMID:23516142] xref: MESH:D000073637 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: BFO:0000050 CL:0000125 ! part of glial cell relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002202 CL:0000047 ! develops from neural stem cell relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata) relationship: RO:0002203 CL:4023059 ! develops into committed oligodendrocyte precursor creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell def: "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002462 name: adipose dendritic cell def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part tyrosine-protein phosphatase non-receptor type substrate 1 creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002477 name: adipose macrophage def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000864 ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1 creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1 relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_subset subset: mouse_subset synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1 creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002494 name: cardiocyte def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. subset: human_subset subset: mouse_subset synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002503 name: adventitial cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0005742 ! part of adventitia relationship: BFO:0000050 UBERON:0005742 ! part of adventitia creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002521 name: subcutaneous adipocyte def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "subcutaneous fat cell" EXACT [] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue relationship: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002539 name: aortic smooth muscle cell def: "A smooth muscle cell of the aorta." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0004577 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue relationship: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002543 name: vein endothelial cell def: "An endothelial cell that is part of the vein." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002547 name: fibroblast of the aortic adventitia def: "A fibroblast of the aortic adventitia." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia relationship: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia creation_date: 2011-02-28T04:43:41Z [Term] id: CL:0002548 name: fibroblast of cardiac tissue def: "A fibroblast that is part of the heart." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cardiac fibroblast" EXACT [] is_a: CL:0000057 ! fibroblast is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart creation_date: 2011-02-28T04:57:44Z [Term] id: CL:0002549 name: fibroblast of choroid plexus def: "A fibroblast that is part of the choroid plexus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast is_a: CL:0002319 ! neural cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus creation_date: 2011-02-28T05:01:39Z [Term] id: CL:0002551 name: fibroblast of dermis def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis creation_date: 2011-02-28T05:05:33Z [Term] id: CL:0002553 name: fibroblast of lung def: "A fibroblast that is part of lung." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: BTO:0000764 xref: CALOHA:TS-0575 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung creation_date: 2011-02-28T05:11:03Z [Term] id: CL:0002557 name: fibroblast of pulmonary artery def: "A fibroblast of pulmonary artery." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery creation_date: 2011-02-28T05:22:27Z [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "mesenchymal stem cell of adipose" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue creation_date: 2011-03-01T09:57:17Z [Term] id: CL:0002573 name: Schwann cell def: "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." [GOC:tfm, PMID:16807057] comment: A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle. {xref="PMID:16807057"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "neurolemmocyte" EXACT [PMID:32119275, PMID:38638689] xref: BTO:0001220 xref: CALOHA:TS-0898 xref: MESH:D012583 is_a: CL:0000125 ! glial cell relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system creation_date: 2011-03-02T01:19:27Z [Term] id: CL:0002585 name: retinal blood vessel endothelial cell def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina creation_date: 2011-03-06T03:28:27Z [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery creation_date: 2011-03-06T05:00:58Z [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain creation_date: 2011-03-06T05:01:20Z [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery def: "A smooth muscle of the pulmonary artery." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0003336 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery creation_date: 2011-03-06T05:01:28Z [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery creation_date: 2011-03-06T05:01:52Z [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery def: "Smooth muscle cell of the carotid artery." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment creation_date: 2011-03-06T05:01:56Z [Term] id: CL:0002598 name: bronchial smooth muscle cell def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0004402 is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus creation_date: 2011-03-06T05:46:39Z [Term] id: CL:0002599 name: smooth muscle cell of the esophagus def: "A smooth muscle cell of the esophagus." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus creation_date: 2011-03-06T05:48:17Z [Term] id: CL:0002600 name: smooth muscle cell of trachea def: "A smooth muscle cell of the trachea." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea creation_date: 2011-03-06T05:50:28Z [Term] id: CL:0002603 name: astrocyte of the cerebellum def: "An astrocyte of the cerebellum." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000127 ! astrocyte is_a: CL:2000005 ! brain macroglial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum creation_date: 2011-03-06T06:57:27Z [Term] id: CL:0002606 name: astrocyte of the spinal cord def: "An astrocyte of the spinal cord." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0000127 ! astrocyte intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord creation_date: 2011-03-06T07:11:26Z [Term] id: CL:0002610 name: raphe nuclei neuron def: "A neuron of the raphe nuclei." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei relationship: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord def: "A neuron of the ventral spinal cord." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord relationship: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord creation_date: 2011-03-06T07:46:03Z [Term] id: CL:0002613 name: striatum neuron def: "A neuron of the striatum." [GOC:tfm] subset: human_subset subset: mouse_subset is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002435 ! has soma location striatum relationship: RO:0002100 UBERON:0002435 ! has soma location striatum creation_date: 2011-03-06T07:47:12Z [Term] id: CL:0002620 name: skin fibroblast def: "A fibroblast of skin." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: BTO:0001255 xref: CALOHA:TS-0935 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body creation_date: 2011-03-14T12:31:49Z [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002368 ! respiratory tract epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium relationship: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002653 name: squamous endothelial cell def: "A squamous shaped endothelial cell." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell creation_date: 2011-07-08T03:31:25Z [Term] id: CL:0002657 name: glandular cell of esophagus def: "A glandular epithelial cell of the esophagus." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: FMA:86548 is_a: CL:0000150 ! glandular secretory epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular secretory epithelial cell intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus creation_date: 2011-07-08T03:55:57Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83389 is_a: CL:0002074 ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. subset: human_subset subset: mouse_subset synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164] is_a: CL:0000048 ! multi fate stem cell creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002672 name: retinal progenitor cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000048 ! multi fate stem cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell creation_date: 2011-08-16T02:38:01Z [Term] id: CL:0002673 name: tongue muscle cell def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: BFO:0000050 UBERON:0000378 ! part of tongue muscle relationship: BFO:0000050 UBERON:0000378 ! part of tongue muscle creation_date: 2011-08-16T03:10:02Z [Term] id: CL:0002676 name: neural crest derived neuroblast def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] subset: human_subset subset: mouse_subset is_a: CL:0000031 ! neuroblast (sensu Vertebrata) relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell creation_date: 2011-08-22T09:24:15Z [Term] id: CL:0005000 name: spinal cord interneuron def: "A CNS interneuron located in the spinal cord." [CL:CVS] comment: Is_a interneuron, part_of UBERON:0002240. subset: human_subset subset: mouse_subset is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord [Term] id: CL:0005024 name: somatomotor neuron def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [ZFIN:CVS] subset: human_subset subset: mouse_subset synonym: "somatic motor neuron" EXACT [] is_a: CL:0000100 ! motor neuron is_a: CL:0000108 ! cholinergic neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber relationship: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber [Term] id: CL:0007001 name: skeletogenic cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) subset: human_subset subset: mouse_subset synonym: "scleroblast" EXACT [GO_REF:0000034] is_a: CL:0000000 ! cell creation_date: 2012-06-15T02:51:27Z [Term] id: CL:0007004 name: premigratory neural crest cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0011012 ! neural crest cell relationship: BFO:0000050 UBERON:0002342 ! part of neural crest relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell creation_date: 2012-06-27T08:27:35Z [Term] id: CL:0007009 name: prechondroblast def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] subset: human_subset subset: mouse_subset is_a: CL:0011026 ! progenitor cell creation_date: 2012-06-27T10:44:01Z [Term] id: CL:0008000 name: non-striated muscle cell def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] subset: human_subset subset: mouse_subset is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate intersection_of: RO:0000053 PATO:0002478 ! bearer of transversely striated relationship: RO:0002202 CL:0000515 ! develops from skeletal muscle myoblast [Term] id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue relationship: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue [Term] id: CL:0008008 name: striated visceral muscle cell def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! bearer of striated [Term] id: CL:0008009 name: transversely striated visceral muscle cell def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! bearer of transversely striated relationship: RO:0000053 PATO:0002478 ! bearer of transversely striated [Term] id: CL:0008017 name: adult skeletal muscle myoblast def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "myogenic precursor cell" BROAD [PMID:23303905] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber [Term] id: CL:0008019 name: mesenchymal cell def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "mesenchyme cell" EXACT [] is_a: CL:0000219 ! motile cell relationship: BFO:0000050 UBERON:0003104 ! part of mesenchyme relationship: RO:0002215 GO:0016477 ! capable of cell migration [Term] id: CL:0008022 name: endocardial cushion cell def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] subset: human_subset subset: mouse_subset is_a: CL:0000569 ! cardiac mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: BFO:0000050 UBERON:0002062 ! part of endocardial cushion relationship: BFO:0000050 UBERON:0002062 ! part of endocardial cushion [Term] id: CL:0008025 name: noradrenergic neuron def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos] subset: human_subset subset: mouse_subset is_a: CL:0000459 ! noradrenergic cell is_a: CL:4033050 ! catecholaminergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission relationship: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission [Term] id: CL:0008028 name: visual system neuron def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002216 GO:0007601 ! capable of part of visual perception relationship: RO:0002216 GO:0007601 ! capable of part of visual perception creation_date: 2017-07-09T19:12:36Z [Term] id: CL:0008034 name: mural cell def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194] subset: added_for_HCA subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:4033054 ! perivascular cell creation_date: 2020-02-29T17:33:55Z [Term] id: CL:0008035 name: microcirculation associated smooth muscle cell def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0008034 ! mural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel relationship: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel creation_date: 2020-02-29T17:37:00Z [Term] id: CL:0008042 name: tanycyte of subfornical organ def: "A tanycyte of the subfornical organ (SFO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SFO, where they form a dense network surrounding these capillaries." [PMID:23649873] subset: human_subset subset: mouse_subset synonym: "tanycyte-like cell of subfornical organ" EXACT [PMID:23649873] is_a: CL:0002085 ! tanycyte intersection_of: CL:0002085 ! tanycyte intersection_of: BFO:0000050 UBERON:0002219 ! part of subfornical organ relationship: BFO:0000050 UBERON:0002219 ! part of subfornical organ [Term] id: CL:0008045 name: tanycyte of subcommissural organ def: "A tanycyte of the subcommisural organ (SCO). These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SCO, where they form a dense network surrounding these capillaries." [PMID:23649873] subset: human_subset subset: mouse_subset synonym: "tanycyte-like cell of subcommissural organ" EXACT [PMID:23649873] is_a: CL:0002085 ! tanycyte intersection_of: CL:0002085 ! tanycyte intersection_of: BFO:0000050 UBERON:0002139 ! part of subcommissural organ relationship: BFO:0000050 UBERON:0002139 ! part of subcommissural organ [Term] id: CL:0008053 name: circumventricular organ capillary endothelial cell def: "A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans." [PMID:26578857, PMID:35726097] subset: human_subset subset: mouse_subset is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000044 ! brain microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0005408 ! part of circumventricular organ relationship: BFO:0000050 UBERON:0005408 ! part of circumventricular organ [Term] id: CL:0008055 name: respiratory tract secretory epithelial cell def: "A secretory epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin." [DOI:10.1038/s41591-023-02327-2.] subset: human_subset subset: mouse_subset is_a: CL:0002368 ! respiratory tract epithelial cell is_a: CL:1100001 ! secretory epithelial cell intersection_of: CL:1100001 ! secretory epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium [Term] id: CL:0008059 name: GABA-Gly neuron def: "A neuron that releases both gamma-aminobutyric acid and glycine as vesicular neurotransmitters. Examples include types of amacrine cell and types of cerebellar inhibitory neurons." [PMID:18677503, PMID:37124720] subset: human_subset subset: mouse_subset is_a: CL:0000617 ! GABAergic neuron is_a: CL:1001509 ! glycinergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission [Term] id: CL:0008060 name: GABA-Glut neuron def: "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters." [PMID:29924991, PMID:37124720, PMID:38092916] subset: human_subset subset: mouse_subset is_a: CL:0000617 ! GABAergic neuron is_a: CL:0000679 ! glutamatergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission [Term] id: CL:0008061 name: GABA-Chol neuron def: "A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters. Examples include some types of striatal interneuron." [PMID:29651049] subset: human_subset subset: mouse_subset is_a: CL:0000108 ! cholinergic neuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] subset: human_subset subset: mouse_subset synonym: "spinal sensory neuron" EXACT [] is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve relationship: RO:0002100 UBERON:0001780 ! has soma location spinal nerve [Term] id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009004 name: retinal cell def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr] subset: human_subset subset: mouse_subset xref: PMID:10702418 is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: BFO:0000050 UBERON:0005388 ! part of photoreceptor array relationship: BFO:0000050 UBERON:0005388 ! part of photoreceptor array [Term] id: CL:0009097 name: embryonic skeletal muscle fiber def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] subset: human_subset subset: mouse_subset is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage relationship: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage [Term] id: CL:0010001 name: stromal cell of bone marrow def: "A stromal cell that is part_of a bone marrow." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "bone marrow stromal cell" EXACT [] is_a: CL:0000499 ! stromal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0010004 name: mononuclear cell of bone marrow def: "A mononuclear cell that is part_of a bone marrow." [] subset: human_subset subset: mouse_subset synonym: "bone marrow mononuclear cell" EXACT [] is_a: CL:0000842 ! mononuclear leukocyte is_a: CL:1001610 ! bone marrow hematopoietic cell intersection_of: CL:0000842 ! mononuclear leukocyte intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010007 name: His-Purkinje system cell def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010009 name: camera-type eye photoreceptor cell def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated] subset: human_subset subset: mouse_subset synonym: "camera type eye photoreceptor cell" EXACT [] is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000966 ! part of retina [Term] id: CL:0010010 name: cerebellar stellate cell def: "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling." [PMID:31110133, PMID:5042759] subset: human_subset subset: mouse_subset is_a: CL:0000691 ! stellate interneuron is_a: CL:4042035 ! molecular layer interneuron intersection_of: CL:0000122 ! stellate neuron intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex [Term] id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] subset: human_subset subset: mouse_subset xref: MESH:D015053 is_a: CL:0000000 ! cell [Term] id: CL:0010020 name: cardiac glial cell def: "Any glial cell that is part of some heart." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010021 name: cardiac myoblast def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated] subset: human_subset subset: mouse_subset xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell relationship: RO:0002203 CL:0000746 ! develops into cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] comment: This term is used in 3 GO terms that were created as part of the heart development focus project. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart relationship: RO:0002100 UBERON:0000948 ! has soma location heart [Term] id: CL:0011001 name: spinal cord motor neuron def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord [Term] id: CL:0011005 name: GABAergic interneuron def: "An interneuron that uses GABA as a vesicular neurotransmitter. These interneurons are inhibitory" [GOC:CellBLAST, GOC:nv, PMID:29724907] comment: The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges. subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "GABAergic inhibitory interneuron" EXACT [] is_a: CL:0000498 ! inhibitory interneuron is_a: CL:0000617 ! GABAergic neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0011007 name: paraxial cell def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] subset: human_subset subset: mouse_subset synonym: "paraxial mesoderm cell" EXACT [] synonym: "presomitic mesoderm cell" NARROW [] synonym: "somitic mesoderm cell" EXACT [] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm relationship: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm [Term] id: CL:0011012 name: neural crest cell def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0011019 name: mesothelial cell of epicardium def: "A mesothelial cell that is part of the epicardium." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000077 ! mesothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002348 ! part of epicardium relationship: BFO:0000050 UBERON:0002348 ! part of epicardium [Term] id: CL:0011021 name: fibroblast of upper back skin def: "A fibroblast that is part of upper back skin." [] subset: human_subset subset: mouse_subset is_a: CL:0011022 ! fibroblast of skin of back intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0009015 ! part of upper back skin relationship: BFO:0000050 UBERON:0009015 ! part of upper back skin [Term] id: CL:0011022 name: fibroblast of skin of back def: "A fibroblast that is part of skin of back." [] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001068 ! part of skin of back relationship: BFO:0000050 UBERON:0001068 ! part of skin of back [Term] id: CL:0011026 name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002202 CL:0000034 ! develops from stem cell relationship: RO:0002202 CL:0000034 ! develops from stem cell [Term] id: CL:0011027 name: skeletal muscle fibroblast def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "skeleton muscle fibroblast" EXACT [] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:1001609 ! muscle fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue [Term] id: CL:0011028 name: olfactory ensheathing cell def: "A neural-crest derived glial cell that supports the growth and survival of primary olfactory neuroons from the neuroepithelium in the nasal cavity to the brain by encasing large bundles of numerous unmyelinated axons." [PMID:22456085] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "OEC" EXACT [] xref: BTO:0002771 is_a: CL:0000125 ! glial cell [Term] id: CL:0011030 name: dermal microvascular endothelial cell def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity] subset: human_subset subset: mouse_subset synonym: "dermal microvascular endothelium cell" EXACT [] synonym: "DMEC cell" EXACT [] is_a: CL:2000008 ! microvascular endothelial cell is_a: CL:2000010 ! dermis blood vessel endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: CL:0011111 name: hypothalamic gonadotropin-releasing hormone neuron def: "a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation." [GOC:NV, PMID:20807514, PMID:21828096, PMID:26053743, PMID:34128468, PMID:35067985] subset: human_subset subset: mouse_subset synonym: "GnRH neuron" EXACT [] synonym: "GnRH-secreting neuron" EXACT [] is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0012001 ! neuron of the forebrain relationship: RO:0002596 GO:0032274 ! capable of regulating gonadotropin secretion [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0030154 ! capable of cell differentiation relationship: RO:0002215 GO:0030154 ! capable of cell differentiation [Term] id: CL:0012000 name: astrocyte of the forebrain def: "An astrocyte of the forebrain." [] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "forebrain astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte is_a: CL:2000005 ! brain macroglial cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain [Term] id: CL:0012001 name: neuron of the forebrain def: "A CNS neuron of the forebrain." [] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "forebrain neuron" EXACT [] is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001890 ! has soma location forebrain relationship: RO:0002100 UBERON:0001890 ! has soma location forebrain [Term] id: CL:0013000 name: forebrain radial glial cell def: "Any radial glial cell that is part of some forebrain." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain [Term] id: CL:0017500 name: neutrophillic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070046 ! bearer of neutrophillic relationship: RO:0000053 PATO:0070046 ! bearer of neutrophillic creation_date: 2010-05-25T01:36:34Z [Term] id: CL:0017502 name: acidophilic cytoplasm def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] synonym: "eosinophilic" NARROW [] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002418 ! bearer of acidophilic relationship: RO:0000053 PATO:0002418 ! bearer of acidophilic creation_date: 2009-12-22T04:23:25Z [Term] id: CL:0017503 name: basophilic cytoplasm def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002094 ! bearer of basophilic relationship: RO:0000053 PATO:0002094 ! bearer of basophilic creation_date: 2009-12-22T04:24:54Z [Term] id: CL:0017504 name: polychromatophilic cytoplasm def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070047 ! bearer of polychromatophilic relationship: RO:0000053 PATO:0070047 ! bearer of polychromatophilic creation_date: 2009-12-28T04:25:23Z [Term] id: CL:0019001 name: tracheobronchial serous cell def: "Any serous secreting cell that is part of the tracheobronchial epithelium." [] subset: added_for_HCA subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "serous cell of tracheobronchial tree" EXACT [] is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000313 ! serous secreting cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree [Term] id: CL:0019002 name: tracheobronchial chondrocyte def: "Any chondrocyte that is part of the tracheobronchial tree." [] subset: added_for_HCA subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "chondrocyte of tracheobronchial tree" EXACT [] is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree [Term] id: CL:0019018 name: blood vessel smooth muscle cell def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of blood vessel" EXACT [] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel [Term] id: CL:0019019 name: tracheobronchial smooth muscle cell def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867] comment: The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the lung with a confidence of 0.69 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of tracheobronchial tree" EXACT [] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0015004 CLM:1000056 ! has characterizing marker set NS forest marker set of tracheobronchial smooth muscle cell (Human lung). [Term] id: CL:1000042 name: forebrain neuroblast def: "Any neuroblast (sensu Vertebrata) that is part of some forebrain." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0002319 ! neural cell intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain relationship: BFO:0000050 UBERON:0001890 ! part of forebrain [Term] id: CL:1000073 name: spinal cord radial glial cell def: "Any radial glial cell that is part of some spinal cord." [FBC:Autogenerated] subset: human_subset subset: mouse_subset is_a: CL:0000681 ! radial glial cell intersection_of: CL:0000681 ! radial glial cell intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord [Term] id: CL:1000223 name: pulmonary neuroendocrine cell def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] comment: The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung neuroendocrine cell" EXACT [PMID:15018448] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0000206 ! chemoreceptor cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000051 GO:0031045 ! has part dense core granule relationship: RO:0002215 GO:0070483 ! capable of detection of hypoxia relationship: RO:0015004 CLM:1000043 ! has characterizing marker set NS forest marker set of pulmonary neuroendocrine cell (Human lung). [Term] id: CL:1000272 name: lung secretory cell def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:1000274 name: trophectodermal cell def: "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." [PMID:22918806] subset: human_subset subset: mouse_subset synonym: "trophectoderm cell" EXACT [] is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: BFO:0000050 UBERON:0004345 ! part of trophectoderm relationship: BFO:0000050 UBERON:0004345 ! part of trophectoderm relationship: RO:0002203 CL:0000351 ! develops into trophoblast cell [Term] id: CL:1000298 name: mesothelial cell of dura mater def: "A mesothelial cell that is part of the dura mater." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516] xref: FMA:256516 is_a: CL:0000077 ! mesothelial cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002363 ! part of dura mater relationship: BFO:0000050 UBERON:0002363 ! part of dura mater [Term] id: CL:1000303 name: fibroblast of areolar connective tissue def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261279 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue relationship: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261285 is_a: CL:4052030 ! adventitial fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0007240 ! part of tunica adventitia of artery relationship: BFO:0000050 UBERON:0007240 ! part of tunica adventitia of artery [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue relationship: BFO:0000050 UBERON:0002521 ! part of elastic tissue relationship: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue [Term] id: CL:1000309 name: epicardial adipocyte def: "An adipocyte that is part of the epicardial fat." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "adipocyte of epicardial fat" EXACT [FMA:261293] synonym: "epicardial fat cell" EXACT [FMA:261293] xref: FMA:261293 is_a: CL:0000136 ! adipocyte is_a: CL:0002494 ! cardiocyte relationship: BFO:0000050 UBERON:0002348 ! part of epicardium [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297] synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297] xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300] synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300] xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: CL:1000330 name: serous cell of epithelium of trachea def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263078 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea [Term] id: CL:1000331 name: serous cell of epithelium of bronchus def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:263080 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus [Term] id: CL:1000361 name: transitional myocyte of interatrial septum def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263152 is_a: CL:0002073 ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002085 ! part of interatrial septum relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263154 is_a: CL:0002073 ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:263182 is_a: CL:0002068 ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000409 name: myocyte of sinoatrial node def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "SA nodal myocyte" EXACT [FMA:67102] synonym: "SA node cardiac muscle cell" EXACT [GOC:pr] synonym: "sinoatrial node cell" EXACT [GOC:pr] synonym: "sinoatrial node myocyte" EXACT [] synonym: "sinuatrial node myocyte" EXACT [FMA:67102] xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node relationship: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] subset: human_subset subset: mouse_subset synonym: "atrioventricular node cell" EXACT [GOC:pr] synonym: "atrioventricular node myocyte" EXACT [FMA:67106] synonym: "AV nodal myocyte" EXACT [FMA:67106] synonym: "AV node cardiac muscle cell" EXACT [GOC:pr] synonym: "AV node cell" EXACT [GOC:pr] xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node relationship: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000412 name: endothelial cell of arteriole def: "An endothelial cell that is part of the arteriole." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67760 xref: KUPO:0001097 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole relationship: BFO:0000050 UBERON:0001980 ! part of arteriole [Term] id: CL:1000413 name: endothelial cell of artery def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001917 ! part of endothelium of artery [Term] id: CL:1000414 name: endothelial cell of venule def: "An endothelial cell that is part of the venule." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:67762 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0001979 ! part of venule relationship: BFO:0000050 UBERON:0001979 ! part of venule [Term] id: CL:1000428 name: stem cell of epidermis def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis [Term] id: CL:1000443 name: ciliary muscle cell def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_subset subset: mouse_subset synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610] xref: FMA:70610 is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:70615 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum relationship: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum [Term] id: CL:1000465 name: chromaffin cell of ovary def: "A chromaffin cell that is part of the ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74319 is_a: CL:0000166 ! chromaffin cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:1000466 name: chromaffin cell of right ovary def: "A chromaffin cell that is part of the right ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74320 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002118 ! part of right ovary relationship: BFO:0000050 UBERON:0002118 ! part of right ovary [Term] id: CL:1000467 name: chromaffin cell of left ovary def: "A chromaffin cell that is part of the left ovary." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:74321 is_a: CL:1000465 ! chromaffin cell of ovary intersection_of: CL:0000166 ! chromaffin cell intersection_of: BFO:0000050 UBERON:0002119 ! part of left ovary relationship: BFO:0000050 UBERON:0002119 ! part of left ovary [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 is_a: CL:0002073 ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83386 is_a: CL:0002068 ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:83390 is_a: CL:0002074 ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000490 name: mesothelial cell of peritoneum def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] subset: human_subset subset: mouse_subset synonym: "peritoneal mesothelial cell" EXACT [FMA:86736] xref: FMA:86736 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura def: "A mesothelial cell that is part of the pleura." [GOC:tfm] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura relationship: BFO:0000050 UBERON:0000977 ! part of pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] subset: human_subset subset: mouse_subset xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002400 ! part of parietal pleura relationship: BFO:0000050 UBERON:0002400 ! part of parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset xref: FMA:86739 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002401 ! part of visceral pleura relationship: BFO:0000050 UBERON:0002401 ! part of visceral pleura [Term] id: CL:1001474 name: medium spiny neuron def: "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." [doi:10.1073/pnas.242428599, MP:0008462] comment: Direct genetic lineage tracing in mice, including Dlx-based and Sp9-Cre fate mapping, demonstrates that medium spiny neurons (MSNs) originate from progenitors in the lateral ganglionic eminence (LGE), with labeled cells migrating from LGE to the striatum and expressing MSN markers such as FOXP1 and CTIP2. {xref="doi:10.1523/JNEUROSCI.20-16-06063.2000", xref="doi:10.1038/s41420-022-01088-0"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "gamma-aminobutyric acid (GABA)ergic spiny projection neuron" EXACT [doi:10.1073/pnas.242428599] synonym: "gamma-aminobutyric acid ergic spiny projection neuron" EXACT [doi:10.1073/pnas.242428599] synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778] synonym: "striatal medium spiny neuron" EXACT [GO:0021773] xref: BTO:0004778 is_a: CL:0000617 ! GABAergic neuron is_a: CL:4023035 ! lateral ganglionic eminence derived neuron relationship: RO:0002100 UBERON:0000369 ! has soma location corpus striatum [Term] id: CL:1001509 name: glycinergic neuron def: "The neurons that utilize glycine as a neurotransmitter." [MP:0010385] subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission relationship: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission [Term] id: CL:1001567 name: lung endothelial cell def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "endothelial cell of lung" RELATED [] synonym: "pulmonary vessel endothelial cell" RELATED [] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0000102 ! part of lung vasculature [Term] id: CL:1001568 name: pulmonary artery endothelial cell def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "PAEC cell" RELATED [BTO:0001141] xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0005317 ! part of pulmonary artery endothelium [Term] id: CL:1001576 name: oral mucosa squamous cell def: "Squamous cell of oral epithelium." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252] synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252] synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252] xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0002424 ! part of oral epithelium relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium [Term] id: CL:1001581 name: lateral ventricle glial cell def: "Glial cell of lateral ventricle." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258] xref: CALOHA:TS-1258 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle relationship: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle [Term] id: CL:1001582 name: lateral ventricle neuron def: "Neuron of lateral ventricle." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261] synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261] xref: CALOHA:TS-1261 is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle relationship: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle [Term] id: CL:1001603 name: lung macrophage def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [HPA:HPA, NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lung macrophages" RELATED [CALOHA:TS-0576] xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:1001609 name: muscle fibroblast def: "Fibroblast from muscle organ." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] subset: human_subset subset: mouse_subset synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109] synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109] xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow relationship: BFO:0000050 UBERON:0012429 ! part of hematopoietic tissue [Term] id: CL:1001611 name: cerebellar neuron def: "Neuron of the cerebellum." [NPX:PDR] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359] xref: CALOHA:TS-2359 xref: FMA:84665 is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum [Term] id: CL:1100001 name: secretory epithelial cell def: "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." [https://orcid.org/0000-0002-7073-9172] subset: human_subset subset: mouse_subset is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000066 ! epithelial cell intersection_of: CL:0000151 ! secretory cell [Term] id: CL:2000001 name: peripheral blood mononuclear cell def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear leukocyte intersection_of: CL:0000842 ! mononuclear leukocyte intersection_of: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000050 UBERON:0000178 ! part of blood creation_date: 2014-02-11T17:29:04Z [Term] id: CL:2000004 name: pituitary gland cell def: "Any cell that is part of a pituitary gland." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000007 ! part of pituitary gland relationship: BFO:0000050 UBERON:0000007 ! part of pituitary gland creation_date: 2014-03-26T22:14:56Z [Term] id: CL:2000005 name: brain macroglial cell def: "Any macroglial cell that is part of a brain." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000126 ! macroglial cell intersection_of: CL:0000126 ! macroglial cell intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain creation_date: 2014-03-28T21:35:27Z [Term] id: CL:2000008 name: microvascular endothelial cell def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium relationship: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium creation_date: 2014-06-04T15:07:42Z [Term] id: CL:2000010 name: dermis blood vessel endothelial cell def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis relationship: BFO:0000050 UBERON:0002067 ! part of dermis creation_date: 2014-06-04T15:12:06Z [Term] id: CL:2000013 name: fibroblast of skin of abdomen def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0001416 ! part of skin of abdomen relationship: BFO:0000050 UBERON:0001416 ! part of skin of abdomen creation_date: 2014-06-04T15:18:16Z [Term] id: CL:2000016 name: lung microvascular endothelial cell def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:1001567 ! lung endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:1001567 ! lung endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium creation_date: 2014-06-04T16:00:56Z [Term] id: CL:2000019 name: compound eye photoreceptor cell def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000018 ! part of compound eye relationship: BFO:0000050 UBERON:0000018 ! part of compound eye creation_date: 2014-06-24T23:16:45Z [Term] id: CL:2000020 name: inner cell mass cell def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000087 ! part of inner cell mass relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass creation_date: 2014-06-24T23:16:53Z [Term] id: CL:2000022 name: cardiac septum cell def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum creation_date: 2014-06-24T23:17:07Z [Term] id: CL:2000025 name: spinal cord oligodendrocyte def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000128 ! oligodendrocyte intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord creation_date: 2014-06-25T00:23:50Z [Term] id: CL:2000027 name: cerebellar basket cell def: "A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions." [PMID:32990595, PMID:8915580] subset: human_subset subset: mouse_subset synonym: "cerebellum basket cell" EXACT [] is_a: CL:0000118 ! basket cell is_a: CL:4042035 ! molecular layer interneuron intersection_of: CL:0000118 ! basket cell intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum creation_date: 2014-06-25T00:24:03Z [Term] id: CL:2000028 name: cerebellum glutamatergic neuron def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000679 ! glutamatergic neuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0000679 ! glutamatergic neuron intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum creation_date: 2014-06-25T00:24:10Z [Term] id: CL:2000029 name: central nervous system neuron def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001017 ! has soma location central nervous system relationship: RO:0002100 UBERON:0001017 ! has soma location central nervous system creation_date: 2014-06-25T01:17:43Z [Term] id: CL:2000030 name: hypothalamus cell def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001898 ! part of hypothalamus relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus creation_date: 2014-06-25T01:17:50Z [Term] id: CL:2000032 name: peripheral nervous system neuron def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "peripheral neuron" EXACT [] synonym: "PNS neuron" EXACT [] xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system creation_date: 2014-06-25T02:28:17Z [Term] id: CL:2000042 name: embryonic fibroblast def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0000922 ! part of embryo creation_date: 2014-07-09T00:12:00Z [Term] id: CL:2000044 name: brain microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain creation_date: 2014-07-09T00:24:53Z [Term] id: CL:2000046 name: ventricular cardiac muscle cell def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle creation_date: 2014-08-12T20:50:28Z [Term] id: CL:2000047 name: brainstem motor neuron def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002298 ! has soma location brainstem relationship: RO:0002100 UBERON:0002298 ! has soma location brainstem creation_date: 2014-10-02T23:52:53Z [Term] id: CL:2000063 name: ovarian fibroblast def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast is_a: CL:0002132 ! stromal cell of ovary intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary creation_date: 2014-10-07T17:57:42Z [Term] id: CL:2000066 name: cardiac ventricle fibroblast def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle creation_date: 2014-10-07T18:35:38Z [Term] id: CL:2000067 name: cardiac atrium fibroblast def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium creation_date: 2014-10-07T18:36:54Z [Term] id: CL:2000068 name: pericardium fibroblast def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium relationship: BFO:0000050 UBERON:0002407 ! part of pericardium creation_date: 2014-10-07T18:38:06Z [Term] id: CL:2000070 name: optic choroid fibroblast def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 subset: human_subset subset: mouse_subset is_a: CL:0000005 ! neural crest derived fibroblast is_a: CL:0000348 ! choroidal cell of the eye intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid creation_date: 2014-10-07T18:50:43Z [Term] id: CL:2000072 name: adipose microvascular endothelial cell def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 subset: human_subset subset: mouse_subset is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue creation_date: 2014-10-07T22:13:45Z [Term] id: CL:2000073 name: migratory cardiac neural crest cell def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] subset: human_subset subset: mouse_subset synonym: "cardiac neural crest cell" EXACT [PMID:33060096] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest relationship: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest creation_date: 2014-11-05T01:18:43Z [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie] subset: human_subset subset: mouse_subset synonym: "mesenchymal stem cell of abdominal adipose" EXACT [] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen creation_date: 2014-12-02T19:10:34Z [Term] id: CL:2000093 name: bronchus fibroblast of lung def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus creation_date: 2015-03-31T21:16:22Z [Term] id: CL:3000004 name: peripheral sensory neuron def: "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." [GOC:CellBLAST, https://www.britannica.com/science/sensory-neuron, https://www.ncbi.nlm.nih.gov/books/NBK539846/, PMID:30096314, PMID:31554486, PMID:35858549, Wikipedia:Sensory_neuron] comment: Typically, a sensory neuron has a pseudounipolar morphology. {xref="Wikipedia:Sensory_neuron"} subset: human_subset subset: mouse_subset is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception creation_date: 2019-02-25T19:34:33Z [Term] id: CL:4023026 name: direct pathway medium spiny neuron def: "A medium spiny neuron that expresses dopamine type 1 receptors and projects to the globus pallidus internus or the substantia nigra pars reticulata." [PMID:34727523, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "dopamine 1 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596] is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor [Term] id: CL:4023029 name: indirect pathway medium spiny neuron def: "A medium spiny neuron that expresses dopamine type 2 receptors and projects to the external globus pallidus." [PMID:34727523, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "dopamine 2 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596] is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor [Term] id: CL:4023035 name: lateral ganglionic eminence derived neuron def: "A neuron that is derived from a precursor cell in the lateral ganglion eminence." [wikipediaversioned:Ganglionic_eminence&oldid=1186824360] subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "LGE-derived neuron" EXACT [PMID:10377350] is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0004025 ! develops from lateral ganglionic eminence relationship: RO:0002202 UBERON:0004025 ! develops from lateral ganglionic eminence [Term] id: CL:4023051 name: vascular leptomeningeal cell def: "A transcriptomically distinct type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Non-neuronal cells', Author Categories: 'CrossArea_subclass', clusters VLMC." [https://cellxgene.cziscience.com/e/5346f9c6-755e-4336-94cc-38706ec00c2f.cxg/, PMID:27284195, PMID:29443965, PMID:30096314, PMID:37824655] subset: BDS_subset subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "VLMC" EXACT [] xref: ILX:0770143 is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx relationship: RO:0002202 CL:0011012 ! develops from neural crest cell [Term] id: CL:4023054 name: mesothelial fibroblast def: "A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell." [PMID:26106328] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast relationship: RO:0002202 CL:0000077 ! develops from mesothelial cell [Term] id: CL:4023057 name: cerebellar inhibitory GABAergic interneuron def: "Any GABAergic interneuron that has its soma located in some cerebellar cortex." [FBC:Autogenerated] comment: A GABAergic interneuron whose soma is located in the cerebellar cortex. {xref="DOI:10.1101/2022.10.12.511898"} subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0011005 ! GABAergic interneuron is_a: CL:1001611 ! cerebellar neuron intersection_of: CL:0011005 ! GABAergic interneuron intersection_of: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex relationship: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex [Term] id: CL:4023058 name: mesothelial fibroblast of the leptomeninx def: "A mesothelial fibroblast found in the leptomeninx." [] subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell is_a: CL:4023054 ! mesothelial fibroblast intersection_of: CL:4023054 ! mesothelial fibroblast intersection_of: BFO:0000050 UBERON:0000391 ! part of leptomeninx relationship: BFO:0000050 UBERON:0000391 ! part of leptomeninx [Term] id: CL:4023059 name: committed oligodendrocyte precursor def: "An oligodendrocyte precursor cell that is committed to differentiate." [PMID:32066987] comment: COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from. {xref="PMID:27284195"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "differentiation-committed oligodendrocyte precursor" EXACT [] is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) relationship: RO:0002202 CL:0002453 ! develops from oligodendrocyte precursor cell [Term] id: CL:4023068 name: thalamic excitatory neuron def: "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response." [PMID:30083593, PMID:31196673, PMID:35278647, PMID:37163009, PMID:37824663, PMID:38739251] comment: Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease. {xref="PMID:11532718", xref="PMID:30083593", xref="PMID:38739251"} subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0012001 ! neuron of the forebrain intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0010225 ! has soma location thalamic complex intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission relationship: RO:0002100 UBERON:0010225 ! has soma location thalamic complex [Term] id: CL:4023072 name: brain vascular cell def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0008998 ! part of vasculature of brain relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898] subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:2000029 ! central nervous system neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0001891 ! develops from midbrain relationship: RO:0002202 UBERON:0001891 ! develops from midbrain [Term] id: CL:4023097 name: arachnoid barrier cell def: "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." [PMID:23298861] subset: human_subset subset: mouse_subset is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx relationship: BFO:0000050 UBERON:0000437 ! part of arachnoid barrier layer [Term] id: CL:4023154 name: myelinating glial cell def: "A glial cell that myelinates axonal processes." [DOI:10.1007/3-540-29623-9_3240] subset: human_subset subset: mouse_subset is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: BFO:0000051 GO:0043209 ! has part myelin sheath relationship: BFO:0000051 GO:0043209 ! has part myelin sheath [Term] id: CL:4023161 name: unipolar brush cell def: "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." [PMID:9193142, WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "neuronal brush cell" EXACT [] is_a: CL:0000099 ! interneuron is_a: CL:0000679 ! glutamatergic neuron relationship: BFO:0000051 GO:0044293 ! has part dendriole relationship: RO:0000053 PATO:0070025 ! bearer of unipolar neuron morphology relationship: RO:0002100 UBERON:0002028 ! has soma location hindbrain [Term] id: CL:4023168 name: somatosensory neuron def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660] subset: human_subset subset: mouse_subset is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: BFO:0000050 UBERON:0003942 ! part of somatosensory system intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system relationship: BFO:0000050 UBERON:0003942 ! part of somatosensory system [Term] id: CL:4023181 name: hypendymal cell def: "A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin." [https://orcid.org/0000-0001-7258-9596, PMID:26778959, PMID:9579598] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell relationship: BFO:0000050 UBERON:0002139 ! part of subcommissural organ relationship: RO:0002292 PR:000015658 ! expresses SCO-spondin [Term] id: CL:4028001 name: pulmonary capillary endothelial cell def: "Any capillary endothelial cell that is part of a lung." [] subset: cellxgene_subset subset: human_subset subset: mouse_subset synonym: "lung capillary endothelial cell" EXACT [] is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000016 ! lung microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0016405 ! part of pulmonary capillary creation_date: 2021-11-23T02:31:40Z [Term] id: CL:4030029 name: blood lymphocyte def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331] subset: blood_and_immune_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000542 ! lymphocyte is_a: CL:2000001 ! peripheral blood mononuclear cell intersection_of: CL:0000542 ! lymphocyte intersection_of: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:4033008 name: vein endothelial cell of respiratory system def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: CL:4033015 name: retinal astrocyte def: "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." [PMID:25236977, PMID:33796062] comment: In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive. {xref="PMID:33796062", xref="PMID:32555229"} subset: cellxgene_subset subset: eye_upper_slim subset: human_subset subset: mouse_subset is_a: CL:0000127 ! astrocyte is_a: CL:0009004 ! retinal cell intersection_of: CL:0000127 ! astrocyte intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina [Term] id: CL:4033018 name: lung megakaryocyte def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116] subset: cellxgene_subset subset: human_reference_atlas subset: human_subset subset: mouse_subset synonym: "lung resident megakaryocyte" EXACT [PMID:36524131] synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131] is_a: CL:0000556 ! megakaryocyte is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000556 ! megakaryocyte intersection_of: BFO:0000050 UBERON:0000114 ! part of lung connective tissue relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue [Term] id: CL:4033049 name: taste receptor cell of tongue def: "A taste receptor cell that is part of a taste bud of a tongue." [DOI:10.1111/j.1096-3642.1981.tb01137.x, http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf, PMID:10052456, PMID:28655883] subset: human_subset subset: mouse_subset synonym: "gustatory cell of tongue" RELATED [DOI:10.1016/s0022-5320(69)80043-2] is_a: CL:0000209 ! taste receptor cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000209 ! taste receptor cell intersection_of: BFO:0000050 UBERON:0014451 ! part of tongue taste bud relationship: BFO:0000050 UBERON:0014451 ! part of tongue taste bud [Term] id: CL:4033050 name: catecholaminergic neuron def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209] comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"} subset: human_reference_atlas subset: human_subset subset: mouse_subset is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0160043 ! capable of catecholamine secretion, neurotransmission relationship: RO:0002215 GO:0160043 ! capable of catecholamine secretion, neurotransmission [Term] id: CL:4033054 name: perivascular cell def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] subset: cellxgene_subset subset: human_subset subset: mouse_subset is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002220 UBERON:0002049 ! adjacent to vasculature relationship: RO:0002220 UBERON:0002049 ! adjacent to vasculature [Term] id: CL:4033093 name: limbal epithelial stem cell of cornea def: "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." [PMID:20614614, PMID:29105366, PMID:36983561, PMID:37768272] subset: human_subset subset: mouse_subset synonym: "limbal epithelial stem cell" EXACT [PMID:20614614] synonym: "limbal stem cell" EXACT [PMID:17562792] is_a: CL:0000036 ! epithelial fate stem cell intersection_of: CL:0000034 ! stem cell intersection_of: BFO:0000050 UBERON:0006761 ! part of corneo-scleral junction relationship: BFO:0000050 UBERON:0000482 ! part of basal lamina of epithelium relationship: BFO:0000050 UBERON:0006761 ! part of corneo-scleral junction relationship: RO:0002203 CL:0000575 ! develops into corneal epithelial cell [Term] id: CL:4040004 name: mesenchymal stem cell of orbital adipose tissue def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473] subset: human_subset subset: mouse_subset synonym: "OAMSC" EXACT [PMID:31377878] synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878] synonym: "Orbital ASCs" EXACT [PMID:30210548] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0004088 ! part of orbital region [Term] id: CL:4042003 name: border associated macrophage def: "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier." [PMID:37232741, PMID:37626977] comment: In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169. {xref="PMID:29426702", xref="PMID:37232741"} subset: human_subset subset: mouse_subset synonym: "CNS-associated macrophage" RELATED [PMID:37232741] is_a: CL:0000878 ! central nervous system macrophage [Term] id: CL:4042017 name: alpha1-tanycyte def: "The dorsal-most tanycyte type of the third venticle. These cells projects into the ventromedial or dorsomedial nucleus of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β." [PMID:16344112, PMID:26578855, wikipedia:Tanycyte] comment: In rodents, a1 tanycytes are known to express DARPP-32, GPR50, NA Vimentin, Connexin 43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018). {xref="PMID:26578855"} subset: human_subset subset: mouse_subset synonym: "DMH tanycyte" RELATED [PMID:29351662] synonym: "VMH tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte relationship: BFO:0000050 UBERON:0004642 ! part of third ventricle ependyma relationship: RO:0002292 PR:000014419 ! expresses protein S100-B [Term] id: CL:4042018 name: alpha2-tanycyte def: "Tanycyte of the third ventricle, located immediately ventral to alpha-1 tanycytes. These cells project to the ventromedial and arcuate nuclei of the hypothalamus and express the glial marker S-100β." [PMID:16344112, PMID:26578855, PMID:29351662, wikipedia:Tanycyte] comment: In rodents, this type of tanycyte is more developmentally advanced than alpha1 tanycytes, shows a high neurogenic competence and expresses the following markers DARPP-32, Vimentin, GPR50, Connexin-43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018) {xref="PMID:26578855"} subset: human_subset subset: mouse_subset synonym: "dmARH tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte relationship: RO:0002131 UBERON:0001932 ! overlaps arcuate nucleus of hypothalamus relationship: RO:0002292 PR:000014419 ! expresses protein S100-B [Term] id: CL:4042019 name: beta1-tanycyte def: "A type of tanycyte located in ventral part of the lateral wall of the third ventricle and in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending into the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." [PMID:16344112, PMID:26578855, PMID:29351662, Wikipedia:Tanycyte] subset: human_subset subset: mouse_subset synonym: "vmARH tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte is_a: CL:1100001 ! secretory epithelial cell relationship: BFO:0000050 UBERON:0006250 ! part of infundibular recess of 3rd ventricle relationship: RO:0002131 UBERON:0002197 ! overlaps median eminence of neurohypophysis relationship: RO:0002215 GO:0032274 ! capable of gonadotropin secretion relationship: RO:0002292 PR:000007479 ! expresses fibroblast growth factor 1 relationship: RO:0002292 PR:000007489 ! expresses fibroblast growth factor 2 [Term] id: CL:4042020 name: beta2-tanycyte def: "A type of tanycyte located in the floor of third ventricle and the infindibular recess. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." [PMID:16344112, PMID:26578855, PMID:29351662, wikipedia:Tanycyte] subset: human_subset subset: mouse_subset synonym: "ME tanycyte" RELATED [PMID:29351662] is_a: CL:0002085 ! tanycyte relationship: BFO:0000050 UBERON:0006250 ! part of infundibular recess of 3rd ventricle relationship: RO:0002131 UBERON:0002197 ! overlaps median eminence of neurohypophysis relationship: RO:0002292 PR:000007479 ! expresses fibroblast growth factor 1 relationship: RO:0002292 PR:000007489 ! expresses fibroblast growth factor 2 [Term] id: CL:4042035 name: molecular layer interneuron def: "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties." [PMID:30742002, PMID:33075461, PMID:34616064, PMID:38692278] subset: human_subset subset: mouse_subset synonym: "MLI" RELATED [PMID:33075461] {RELATED="OMO:0003000"} is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission relationship: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex [Term] id: CL:4052002 name: syncytial cell def: "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." [PMID:20851884, Wikipedia:Syncytium] subset: human_subset subset: mouse_subset synonym: "syncytium" EXACT [WBbt:0008074] is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate intersection_of: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion relationship: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion [Term] id: CL:4052015 name: endocrine gland capillary endothelial cell def: "Any capillary endothelial cell that is part of an endocrine gland." [PMID:18480313] subset: human_subset subset: mouse_subset is_a: CL:0002144 ! capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0002368 ! part of endocrine gland relationship: BFO:0000050 UBERON:0002368 ! part of endocrine gland [Term] id: CL:4052016 name: pituitary gland capillary endothelial cell def: "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling." [PMID:10810312, PMID:32910242] comment: In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure. {xref="PMID:4899902"} subset: human_subset subset: mouse_subset is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:2000004 ! pituitary gland cell is_a: CL:2000044 ! brain microvascular endothelial cell is_a: CL:4052015 ! endocrine gland capillary endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0000007 ! part of pituitary gland [Term] id: CL:4052017 name: choroid plexus capillary endothelial cell def: "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)." [https://www.ncbi.nlm.nih.gov/books/NBK27998/, PMID:18480313, PMID:32375819] subset: human_subset subset: mouse_subset is_a: CL:0000666 ! fenestrated endothelial cell is_a: CL:0002144 ! capillary endothelial cell is_a: CL:2000044 ! brain microvascular endothelial cell intersection_of: CL:0002144 ! capillary endothelial cell intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus [Term] id: CL:4052030 name: adventitial fibroblast def: "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" [PMID:28705796, PMID:36718802] comment: Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice. {xref="PMID:36718802"} subset: human_subset subset: mouse_subset is_a: CL:0000057 ! fibroblast is_a: CL:0000151 ! secretory cell is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood vessel relationship: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood vessel relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion [Term] id: CL:4052045 name: steroidogenic stromal cell of ovary def: "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones." [doi:/10.1101/2024.12.15.628550, PMID:36205477] subset: human_subset subset: mouse_subset synonym: "Enpp2− interstitial cell" RELATED [PMID:36205477] synonym: "steroidogenic interstitial stromal cell" BROAD [PMID:36205477] synonym: "steroidogenic stromal cell" BROAD [PMID:36205477] is_a: CL:0002132 ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0006960 ! part of ovary stroma intersection_of: RO:0002215 GO:0120178 ! capable of steroid hormone biosynthetic process relationship: BFO:0000050 UBERON:0006960 ! part of ovary stroma relationship: RO:0002215 GO:0120178 ! capable of steroid hormone biosynthetic process [Term] id: CL:4072001 name: newly formed oligodendrocyte def: "A post-mitotic oligodendrocyte that has exited the cell cycle and begun early stage differentiation. The cell begins to acquire oligodendrocyte-like characteristics but has not yet initiated myelination. In mice, NFOL is marked by the expression of Tcf7l2 and Cemip2 (also known as Tmem2), among other early myelin-related genes. These markers highlight cells transitioning from a precursor to a more differentiated, pre-myelinating state." [PMID:27284195, PMID:39233334] subset: human_subset subset: mouse_subset is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000128 ! oligodendrocyte relationship: RO:0002207 CL:4023059 ! directly develops from committed oligodendrocyte precursor [Term] id: CL:4072002 name: myelin-forming oligodendrocyte def: "A postmitotic and differentiated oligodendrocyte derived from a oligodendrocyte progenitor cell. A myelin-forming oligodendrocyte begins the expression of myelin genes and actively engages in the myelination process. In mice and humans, it is characterized by the upregulation of the key myelin-associated markers Mbp and Opalin. Additionally, Ctps (CTP synthase) shows peak expression at this stage, suggesting a heightened demand for nucleotide biosynthesis during membrane expansion and myelin production." [PMID:27284195, PMID:30837646, PMID:39233334, PMID:9473608] subset: human_subset subset: mouse_subset is_a: CL:0000128 ! oligodendrocyte is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002207 CL:4072001 ! directly develops from newly formed oligodendrocyte relationship: RO:0002215 GO:0032289 ! capable of central nervous system myelin formation [Term] id: CL:4072003 name: mature myelinating oligodendrocyte def: "A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance." [PMID:27284195, PMID:33203872] subset: human_subset subset: mouse_subset is_a: CL:0000128 ! oligodendrocyte is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002207 CL:4072002 ! directly develops from myelin-forming oligodendrocyte relationship: RO:0002215 GO:0032289 ! capable of central nervous system myelin formation [Term] id: CL:4072102 name: Purkinje layer interneuron def: "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex." [PMID:35803588] subset: human_subset subset: mouse_subset is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex [Term] id: CL:4300028 name: cerebellar GABAergic neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:28 CB GABA." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "28 CB GABA" EXACT [] is_a: CL:0000617 ! GABAergic neuron is_a: CL:1001611 ! cerebellar neuron relationship: RO:0002100 MBA:512 ! has soma location Cerebellum relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4300029 name: cerebellar glutamatergic neuron (Mmus) def: "A cerebellum glutamatergic neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:29 CB Glut." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "29 CB Glut" EXACT [] is_a: CL:2000028 ! cerebellum glutamatergic neuron relationship: RO:0002100 MBA:512 ! has soma location Cerebellum relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4300031 name: OPC-Oligo cell (Mmus) def: "A cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:31 OPC-Oligo." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "31 OPC-Oligo" EXACT [] is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4300101 name: STR D1 Gaba direct pathway medium spiny neuron (Mmus) def: "A direct pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:061 STR D1 Gaba." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "061 STR D1 Gaba" EXACT [] synonym: "Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus) expressing direct pathway medium spiny neuron of brain (Mus musculus)" EXACT [] is_a: CL:4023026 ! direct pathway medium spiny neuron [Term] id: CL:4300102 name: STR D2 Gaba indirect pathway medium spiny neuron (Mmus) def: "A indirect pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:062 STR D2 Gaba." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "062 STR D2 Gaba" EXACT [] synonym: "Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus) expressing indirect pathway medium spiny neuron of brain (Mus musculus)" EXACT [] is_a: CL:4023029 ! indirect pathway medium spiny neuron [Term] id: CL:4300348 name: DCO Il22 Gly-Gaba cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem204 (Mmus), Slc6a5 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:308 DCO Il22 Gly-Gaba." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "308 DCO Il22 Gly-Gaba" EXACT [] synonym: "Tmem204 (Mmus), Slc6a5 (Mmus) expressing cerebellar neuron of brain (Mus musculus)" EXACT [] is_a: CL:0008059 ! GABA-Gly neuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) [Term] id: CL:4300349 name: Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:309 CB PLI Gly-Gaba." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "309 CB PLI Gly-Gaba" EXACT [] synonym: "Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4072102 ! Purkinje layer interneuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) [Term] id: CL:4300351 name: CBX MLI Megf11 Gaba molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:311 CBX MLI Megf11 Gaba." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "311 CBX MLI Megf11 Gaba" EXACT [] synonym: "Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4042035 ! molecular layer interneuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) [Term] id: CL:4300353 name: Purkinje cell (Mmus) def: "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:313 CBX Purkinje Gaba." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "313 CBX Purkinje Gaba" EXACT [] synonym: "Pcp2 (Mmus) expressing Purkinje cell of brain (Mus musculus)" EXACT [] is_a: CL:0000121 ! Purkinje cell is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) [Term] id: CL:4300354 name: cerebellar granule cell (Mmus) def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Ror1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:314 CB Granule Glut." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "314 CB Granule Glut" EXACT [] synonym: "Gabra6 (Mmus), Ror1 (Mmus) expressing cerebellar granule cell of brain (Mus musculus)" EXACT [] is_a: CL:0001031 ! cerebellar granule cell is_a: CL:4300029 ! cerebellar glutamatergic neuron (Mmus) [Term] id: CL:4300358 name: subcortical astrocyte (Mmus) def: "A transcriptomically defined type of astrocyte located predominantly in the ventral and posterior subcortical areas. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:318 Astro-NT NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "318 Astro-NT NN" EXACT [] synonym: "Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] synonym: "non-telencephalic astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:4300359 name: astrocyte of cerebrum (Mmus) def: "A transcritpomically defined type of astrocytes primarily restricted to the dorsal regions of the cerebrum. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:319 Astro-TE NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "319 Astro-TE NN" EXACT [] synonym: "Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] synonym: "telencephalic astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:4300360 name: olfactory areas astrocyte (Mmus) def: "A transcriptomically defined type of astrocyte located exclusively in the olfactory areas. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:320 Astro-OLF NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "320 Astro-OLF NN" EXACT [] synonym: "Gja1 (Mmus), Hs3st3a1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:4300362 name: tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Apoe (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:322 Tanycyte NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "322 Tanycyte NN" EXACT [] synonym: "Gpr50 (Mmus), Apoe (Mmus) expressing tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:0002085 ! tanycyte [Term] id: CL:4300363 name: ependymal cell (Mmus) def: "A ependymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem212 (Mmus), Rarres2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:323 Ependymal NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "323 Ependymal NN" EXACT [] synonym: "Tmem212 (Mmus), Rarres2 (Mmus) expressing ependymal cell of brain (Mus musculus)" EXACT [] is_a: CL:0000065 ! ependymal cell [Term] id: CL:4300366 name: oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:326 OPC NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "326 OPC NN" EXACT [] synonym: "Pdgfra (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:0002453 ! oligodendrocyte precursor cell is_a: CL:4300031 ! OPC-Oligo cell (Mmus) [Term] id: CL:4300367 name: oligodendrocyte (Mmus) def: "A oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Gjc3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:327 Oligo NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "327 Oligo NN" EXACT [] synonym: "Cldn11 (Mmus), Gjc3 (Mmus) expressing oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:0000128 ! oligodendrocyte is_a: CL:4300031 ! OPC-Oligo cell (Mmus) [Term] id: CL:4300370 name: VLMC NN vascular leptomeningeal cell (Mmus) def: "A vascular leptomeningeal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Slc6a13 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:330 VLMC NN." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "330 VLMC NN" EXACT [] synonym: "Apod (Mmus), Slc6a13 (Mmus) expressing vascular leptomeningeal cell of brain (Mus musculus)" EXACT [] is_a: CL:4023051 ! vascular leptomeningeal cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4301571 name: DCO Il22 Gly-Gaba_1 cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Rftn1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1141 DCO Il22 Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1141 DCO Il22 Gly-Gaba_1" EXACT [] synonym: "Il22 (Mmus), Rftn1 (Mmus) expressing cerebellar neuron of brain (Mus musculus)" EXACT [] is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus) [Term] id: CL:4301573 name: DCO Il22 Gly-Gaba_3 cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1143 DCO Il22 Gly-Gaba_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1143 DCO Il22 Gly-Gaba_3" EXACT [] synonym: "Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus) expressing cerebellar neuron of brain (Mus musculus)" EXACT [] is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus) [Term] id: CL:4301574 name: CB PLI Gly-Gaba_1 Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hmga2 (Mmus), Afap1l2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1144 CB PLI Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1144 CB PLI Gly-Gaba_1" EXACT [] synonym: "Hmga2 (Mmus), Afap1l2 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) [Term] id: CL:4301575 name: CB PLI Gly-Gaba_2 Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1145 CB PLI Gly-Gaba_2" EXACT [] synonym: "Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:0008059 ! GABA-Gly neuron is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) [Term] id: CL:4301576 name: CB PLI Gly-Gaba_3 Purkinje layer interneuron (Mmus) def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1146 CB PLI Gly-Gaba_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1146 CB PLI Gly-Gaba_3" EXACT [] synonym: "Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) [Term] id: CL:4301578 name: cerebellar Golgi cell (Mmus) def: "A cerebellar Golgi cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Zfp385c (Mmus), Tfap2b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1148 CBX Golgi Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1148 CBX Golgi Gly-Gaba_1" EXACT [] synonym: "310 CBX Golgi Gly-Gaba" EXACT [] synonym: "Zfp385c (Mmus), Tfap2b (Mmus) expressing cerebellar Golgi cell of brain (Mus musculus)" EXACT [] is_a: CL:0000119 ! cerebellar Golgi cell is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) [Term] id: CL:4301579 name: CBX MLI Megf11 Gaba_1 molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1149 CBX MLI Megf11 Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1149 CBX MLI Megf11 Gaba_1" EXACT [] synonym: "Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4300351 ! CBX MLI Megf11 Gaba molecular layer interneuron (Mmus) [Term] id: CL:4301580 name: CBX MLI Megf11 Gaba_2 molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Pvalb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1150 CBX MLI Megf11 Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1150 CBX MLI Megf11 Gaba_2" EXACT [] synonym: "Gabra6 (Mmus), Pvalb (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4300351 ! CBX MLI Megf11 Gaba molecular layer interneuron (Mmus) [Term] id: CL:4301582 name: CBX Purkinje Gaba_1 Purkinje cell (Mmus) def: "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus), Stk17b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1152 CBX Purkinje Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1152 CBX Purkinje Gaba_1" EXACT [] synonym: "Pcp2 (Mmus), Stk17b (Mmus) expressing Purkinje cell of brain (Mus musculus)" EXACT [] is_a: CL:4300353 ! Purkinje cell (Mmus) [Term] id: CL:4301583 name: CBX Purkinje Gaba_2 Purkinje cell (Mmus) def: "A Purkinje cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1153 CBX Purkinje Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1153 CBX Purkinje Gaba_2" EXACT [] is_a: CL:4300353 ! Purkinje cell (Mmus) [Term] id: CL:4301584 name: CB Granule Glut_1 cerebellar granule cell (Mmus) def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1154 CB Granule Glut_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1154 CB Granule Glut_1" EXACT [] synonym: "Gabra6 (Mmus), Lmx1a (Mmus) expressing cerebellar granule cell of brain (Mus musculus)" EXACT [] is_a: CL:4300354 ! cerebellar granule cell (Mmus) [Term] id: CL:4301585 name: CB Granule Glut_2 cerebellar granule cell (Mmus) def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1155 CB Granule Glut_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1155 CB Granule Glut_2" EXACT [] synonym: "Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus) expressing cerebellar granule cell of brain (Mus musculus)" EXACT [] is_a: CL:4300354 ! cerebellar granule cell (Mmus) [Term] id: CL:4301586 name: unipolar brush cell (Mmus) def: "A unipolar brush cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sln (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1156 DCO UBC Glut_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1156 DCO UBC Glut_1" EXACT [] synonym: "315 DCO UBC Glut" EXACT [] synonym: "Sln (Mmus), Lmx1a (Mmus) expressing unipolar brush cell of brain (Mus musculus)" EXACT [] is_a: CL:4023161 ! unipolar brush cell is_a: CL:4300029 ! cerebellar glutamatergic neuron (Mmus) [Term] id: CL:4301589 name: Astro-NT NN_1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1159 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1159 Astro-NT NN_1" EXACT [] synonym: "Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300358 ! subcortical astrocyte (Mmus) [Term] id: CL:4301590 name: Astro-NT NN_2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1160 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1160 Astro-NT NN_2" EXACT [] synonym: "Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300358 ! subcortical astrocyte (Mmus) [Term] id: CL:4301591 name: Astro-TE NN_1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Camk2a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1161 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1161 Astro-TE NN_1" EXACT [] synonym: "Myoc (Mmus), Camk2a (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) [Term] id: CL:4301592 name: Astro-TE NN_2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hepacam (Mmus), E330013P04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1162 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1162 Astro-TE NN_2" EXACT [] synonym: "Hepacam (Mmus), E330013P04Rik (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) [Term] id: CL:4301593 name: Astro-TE NN_3 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1163 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1163 Astro-TE NN_3" EXACT [] synonym: "Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) [Term] id: CL:4301595 name: Astro-TE NN_5 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1165 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1165 Astro-TE NN_5" EXACT [] synonym: "Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) [Term] id: CL:4301596 name: Astro-OLF NN_1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1166 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1166 Astro-OLF NN_1" EXACT [] synonym: "Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300360 ! olfactory areas astrocyte (Mmus) [Term] id: CL:4301597 name: Astro-OLF NN_2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1167 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1167 Astro-OLF NN_2" EXACT [] synonym: "Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300360 ! olfactory areas astrocyte (Mmus) [Term] id: CL:4301598 name: Astro-OLF NN_3 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1168 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1168 Astro-OLF NN_3" EXACT [] synonym: "Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300360 ! olfactory areas astrocyte (Mmus) [Term] id: CL:4301602 name: Tanycyte NN_1 tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Lpl (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1172 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1172 Tanycyte NN_1" EXACT [] synonym: "Cnmd (Mmus), Lpl (Mmus) expressing tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4300362 ! tanycyte (Mmus) [Term] id: CL:4301603 name: Tanycyte NN_2 tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1173 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1173 Tanycyte NN_2" EXACT [] synonym: "Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus) expressing tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4300362 ! tanycyte (Mmus) [Term] id: CL:4301608 name: choroid plexus epithelial cell (Mmus) def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1178 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1178 CHOR NN_1" EXACT [] synonym: "2900040C04Rik (Mmus) expressing choroid plexus epithelial cell of brain (Mus musculus)" EXACT [] synonym: "325 CHOR NN" EXACT [] is_a: CL:0000706 ! choroid plexus epithelial cell [Term] id: CL:4301611 name: commited oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1181 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] subset: mouse_subset synonym: "1181 COP NN_1" EXACT [] synonym: "Gpr17 (Mmus), Bmp4 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4023059 ! committed oligodendrocyte precursor is_a: CL:4300367 ! oligodendrocyte (Mmus) [Term] id: CL:4301612 name: newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ptprb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1182 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] subset: mouse_subset synonym: "1182 NFOL NN_2" EXACT [] synonym: "9630013A20Rik (Mmus), Ptprb (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4072001 ! newly formed oligodendrocyte is_a: CL:4300367 ! oligodendrocyte (Mmus) [Term] id: CL:4301613 name: myelin-forming oligodendrocyte (Mmus) def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1183 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] subset: mouse_subset synonym: "1183 MFOL NN_3" EXACT [] synonym: "Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus) expressing myelin-forming oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4072002 ! myelin-forming oligodendrocyte is_a: CL:4300367 ! oligodendrocyte (Mmus) [Term] id: CL:4301614 name: mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Anln (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1184 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463] subset: mouse_subset synonym: "1184 MOL NN_4" EXACT [] synonym: "Cldn11 (Mmus), Anln (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4072003 ! mature myelinating oligodendrocyte is_a: CL:4300367 ! oligodendrocyte (Mmus) [Term] id: CL:4301615 name: olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Npy (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1185 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1185 OEC NN_1" EXACT [] synonym: "32 OEC" EXACT [] synonym: "328 OEC NN" EXACT [] synonym: "Apod (Mmus), Npy (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" EXACT [] is_a: CL:0011028 ! olfactory ensheathing cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4301616 name: arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Thbd (Mmus), Ccn3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1186 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1186 ABC NN_1" EXACT [] synonym: "329 ABC NN" EXACT [] synonym: "Thbd (Mmus), Ccn3 (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" EXACT [] is_a: CL:4023097 ! arachnoid barrier cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4301625 name: border associated macrophage (Mmus) def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Maf (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1195 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1195 BAM NN_1" EXACT [] synonym: "335 BAM NN" EXACT [] synonym: "Mrc1 (Mmus), Maf (Mmus) expressing border associated macrophage of brain (Mus musculus)" EXACT [] is_a: CL:4042003 ! border associated macrophage relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4304384 name: hypothalamic gonadotropin-releasing hormone neuron (Mmus) def: "A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic. These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "0628 HY Gnrh1 Glut_1" EXACT [] synonym: "142 HY Gnrh1 Glut" EXACT [] synonym: "15 HY Gnrh1 Glut" EXACT [] synonym: "2564 HY Gnrh1 Glut_1" EXACT [] synonym: "Gnrh1 (Mmus) expressing hypothalamic gonadotropin-releasing hormone neuron of brain (Mus musculus)" EXACT [] is_a: CL:0000679 ! glutamatergic neuron is_a: CL:0011111 ! hypothalamic gonadotropin-releasing hormone neuron relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4306426 name: pinealocyte (Mmus) def: "A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic. These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1111/j.1600-079x.1996.tb00284.x, https://doi.org/10.3389/fendo.2019.00590] subset: mouse_subset synonym: "1030 Pineal Crx Glut_1" EXACT [] synonym: "25 Pineal Glut" EXACT [] synonym: "262 Pineal Crx Glut" EXACT [] synonym: "4606 Pineal Crx Glut_1" EXACT [] synonym: "Cngb3 (Mmus), Ush2a (Mmus) expressing pinealocyte of brain (Mus musculus)" EXACT [] is_a: CL:0000652 ! pinealocyte relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Ddc, Slc17a6, Slc17a7"} ! capable of glutamate secretion, neurotransmission [Term] id: CL:4306992 name: DCO Il22 Gly-Gaba_2 cerebellar neuron (Mmus) def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1142 DCO Il22 Gly-Gaba_2" EXACT [] synonym: "5172 DCO Il22 Gly-Gaba_2" EXACT [] synonym: "Il22 (Mmus), Edaradd (Mmus) expressing cerebellar neuron of brain (Mus musculus)" EXACT [] is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus) [Term] id: CL:4307005 name: CB PLI GABA Ly6d Purkinje layer interneuron def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4." [https://doi.org/10.1038/s41586-023-06812-z] comment: Warning: Despite its name, CB PLI Gly-Gaba_4 does not secrete the neurotransmitter Gly, as assessed by expression of multiple marker genes. subset: mouse_subset synonym: "1147 CB PLI Gly-Gaba_4" EXACT [] synonym: "5185 CB PLI Gly-Gaba_4" EXACT [] synonym: "Ly6d (Mmus), Kit (Mmus) expressing Purkinje layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4300349 ! Purkinje layer interneuron (Mmus) [Term] id: CL:4307012 name: CBX MLI Cdh22 Gaba molecular layer interneuron (Mmus) def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1151 CBX MLI Cdh22 Gaba_1" EXACT [] synonym: "312 CBX MLI Cdh22 Gaba" EXACT [] synonym: "5192 CBX MLI Cdh22 Gaba_1" EXACT [] synonym: "Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus) expressing molecular layer interneuron of brain (Mus musculus)" EXACT [] is_a: CL:4042035 ! molecular layer interneuron is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus) [Term] id: CL:4307026 name: Bergmann glial cell (Mmus) def: "A Bergmann glial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr37l1 (Mmus), Ctxn3 (Mmus). It is distinguished from other Astro-Epen cells by expression of Gpr37l1, Ctxn3. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5206 Bergmann NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1157 Bergmann NN_1" EXACT [] synonym: "316 Bergmann NN" EXACT [] synonym: "5206 Bergmann NN_1" EXACT [] synonym: "Gpr37l1 (Mmus), Ctxn3 (Mmus) expressing Bergmann glial cell of brain (Mus musculus)" EXACT [] is_a: CL:0000644 ! Bergmann glial cell [Term] id: CL:4307027 name: cerebellar astrocyte (Mmus) def: "A transcriptomically defined type of astrocyte localized exclusively in the cerebellum beneath the Purkinje cell layer. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Efemp1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5207 Astro-CB NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1158 Astro-CB NN_1" EXACT [] synonym: "317 Astro-CB NN" EXACT [] synonym: "5207 Astro-CB NN_1" EXACT [] synonym: "Dao (Mmus), Efemp1 (Mmus) expressing astrocyte of the cerebellum of brain (Mus musculus)" EXACT [] is_a: CL:0002603 ! astrocyte of the cerebellum [Term] id: CL:4307028 name: Astro-NT NN_1 Galnt15 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Galnt15. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5208 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5208 Astro-NT NN_1" EXACT [] synonym: "Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) [Term] id: CL:4307029 name: Astro-NT NN_1 Slc36a2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Slc36a2, Sfrp5. These cells are located in the Midbrain, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5209 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5209 Astro-NT NN_1" EXACT [] synonym: "Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) [Term] id: CL:4307030 name: Astro-NT NN_1 Nuf2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Nuf2, Shroom3. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5210 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5210 Astro-NT NN_1" EXACT [] synonym: "Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) [Term] id: CL:4307031 name: Astro-NT NN_1 Six3os1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Six3os1. These cells are located in the Striatum-like amygdalar nuclei, Olfactory areas, brain , in or close to the regions: Medial amygdalar nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5211 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5211 Astro-NT NN_1" EXACT [] synonym: "Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) [Term] id: CL:4307032 name: Astro-NT NN_1 Kcnk10 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Agt (Mmus), Prss35 (Mmus), C4b (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Kcnk10, C4b. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5212 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5212 Astro-NT NN_1" EXACT [] synonym: "Agt (Mmus), Prss35 (Mmus), C4b (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) [Term] id: CL:4307033 name: Astro-NT NN_1 Mecom astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Mecom, Prelp. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, Paraflocculus, Flocculus, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5213 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5213 Astro-NT NN_1" EXACT [] synonym: "Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus) [Term] id: CL:4307034 name: Astro-NT NN_2 Fzd2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fzd2, Gria2, Ttll3. These cells are located in the Midbrain, Thalamus, Pons , in or close to the regions: Midbrain reticular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5214 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5214 Astro-NT NN_2" EXACT [] synonym: "Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) [Term] id: CL:4307035 name: Astro-NT NN_2 Sez6l astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Sez6l, Unc13c. These cells are located in the Thalamus , in or close to the regions: Posterior complex of the thalamus, Ventral posteromedial nucleus of the thalamus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5215 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5215 Astro-NT NN_2" EXACT [] synonym: "Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) [Term] id: CL:4307036 name: Astro-NT NN_2 Fam227b astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fam227b, Shroom3. These cells are located in the Midbrain, Medulla, Pons . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5216 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5216 Astro-NT NN_2" EXACT [] synonym: "Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) [Term] id: CL:4307037 name: Astro-NT NN_2 Gm30524 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Gm30524. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5217 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5217 Astro-NT NN_2" EXACT [] synonym: "Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus) [Term] id: CL:4307038 name: Astro-TE NN_1 Myoc astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Kcne1l, Alpk1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5218 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5218 Astro-TE NN_1" EXACT [] synonym: "Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) [Term] id: CL:4307039 name: Astro-TE NN_1 Rasl10b astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Rasl10b, Igfbp5. These cells are located in the Hippocampal region, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5219 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5219 Astro-TE NN_1" EXACT [] synonym: "Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) [Term] id: CL:4307040 name: Astro-TE NN_1 Lncpint astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Lncpint. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5220 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5220 Astro-TE NN_1" EXACT [] synonym: "Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) [Term] id: CL:4307041 name: Astro-TE NN_1 Jph4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5221 Astro-TE NN_1" EXACT [] synonym: "Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Aldh1a1, Slc17a7"} ! capable of glutamate secretion, neurotransmission [Term] id: CL:4307042 name: Astro-TE NN_2 Clstn2 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Clstn2. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Field CA3, stratum oriens, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5222 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5222 Astro-TE NN_2" EXACT [] synonym: "Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301592 ! Astro-TE NN_2 astrocyte (Mmus) [Term] id: CL:4307043 name: Astro-TE NN_2 Mcm6 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Mcm6. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5223 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5223 Astro-TE NN_2" EXACT [] synonym: "Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301592 ! Astro-TE NN_2 astrocyte (Mmus) [Term] id: CL:4307044 name: Astro-TE NN_3 Cxcl5 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Cxcl5, Kif5a. These cells are located in the Hippocampal region, Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5224 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5224 Astro-TE NN_3" EXACT [] synonym: "Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) [Term] id: CL:4307045 name: Astro-TE NN_3 Fam163a astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Fam163a, Nr2f1, Kcnq1ot1. These cells are located in the Isocortex, Olfactory areas . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5225 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5225 Astro-TE NN_3" EXACT [] synonym: "S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) [Term] id: CL:4307046 name: Astro-TE NN_3 Zic4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Zic4. These cells are located in the Lateral septal complex, Isocortex, Olfactory areas , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5226 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5226 Astro-TE NN_3" EXACT [] synonym: "S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) [Term] id: CL:4307047 name: Astro-TE NN_3 Crym astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Crym, Gabbr2. These cells are located in the Striatum dorsal region, Striatum ventral region , in or close to the regions: Nucleus accumbens, Caudoputamen . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5227 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5227 Astro-TE NN_3" EXACT [] synonym: "S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus) [Term] id: CL:4307048 name: Astro-TE NN_4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN cells by expression of Gm29683. These cells are located in the Cortical subplate, brain , in or close to the regions: Lateral amygdalar nucleus, external capsule . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5228 Astro-TE NN_4." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1164 Astro-TE NN_4" EXACT [] synonym: "5228 Astro-TE NN_4" EXACT [] synonym: "S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4300359 ! astrocyte of cerebrum (Mmus) [Term] id: CL:4307049 name: Astro-TE NN_5 Hs3st3a1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Hs3st3a1, Sfrp1. These cells are located in the Olfactory areas, brain , in or close to the regions: Anterior olfactory nucleus, corpus callosum, body, lateral ventricle, corpus callosum, anterior forceps . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5229 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5229 Astro-TE NN_5" EXACT [] synonym: "S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301595 ! Astro-TE NN_5 astrocyte (Mmus) [Term] id: CL:4307050 name: Astro-TE NN_5 Adamts18 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Adamts18. These cells are located in the Lateral septal complex, Striatum dorsal region, brain , in or close to the regions: Nucleus accumbens, Caudoputamen, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5230 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5230 Astro-TE NN_5" EXACT [] synonym: "S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301595 ! Astro-TE NN_5 astrocyte (Mmus) [Term] id: CL:4307051 name: Astro-OLF NN_1 Greb1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Greb1, Il33. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5231 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5231 Astro-OLF NN_1" EXACT [] synonym: "Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301596 ! Astro-OLF NN_1 astrocyte (Mmus) [Term] id: CL:4307052 name: Astro-OLF NN_1 Stk32a astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Stk32a. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5232 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5232 Astro-OLF NN_1" EXACT [] synonym: "Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301596 ! Astro-OLF NN_1 astrocyte (Mmus) [Term] id: CL:4307053 name: Astro-OLF NN_2 Slc25a34 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Slc25a34, C4b. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb, outer plexiform layer, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5233 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5233 Astro-OLF NN_2" EXACT [] synonym: "Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301597 ! Astro-OLF NN_2 astrocyte (Mmus) [Term] id: CL:4307054 name: Astro-OLF NN_2 Alk astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Alk, Atp13a4. These cells are located in the Olfactory areas , in or close to the regions: Anterior olfactory nucleus, Main olfactory bulb, granule layer, Main olfactory bulb, mitral layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5234 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5234 Astro-OLF NN_2" EXACT [] synonym: "S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301597 ! Astro-OLF NN_2 astrocyte (Mmus) [Term] id: CL:4307055 name: Astro-OLF NN_3 Ecrg4 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Ecrg4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5235 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5235 Astro-OLF NN_3" EXACT [] synonym: "C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301598 ! Astro-OLF NN_3 astrocyte (Mmus) [Term] id: CL:4307056 name: Astro-OLF NN_3 Sfrp1 astrocyte (Mmus) def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Sfrp1, Aqp4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5236 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5236 Astro-OLF NN_3" EXACT [] synonym: "S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus) expressing astrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301598 ! Astro-OLF NN_3 astrocyte (Mmus) [Term] id: CL:4307063 name: Tanycyte NN_1 Cnmd tanycyte of subfornical organ (Mmus) def: "A tanycyte of subfornical organ of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Cnmd. These cells are located in the brain , in or close to the regions: choroid plexus, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5243 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5243 Tanycyte NN_1" EXACT [] synonym: "Cnmd (Mmus), Sfta3-ps (Mmus) expressing tanycyte of subfornical organ of brain (Mus musculus)" EXACT [] is_a: CL:0008042 ! tanycyte of subfornical organ is_a: CL:4301602 ! Tanycyte NN_1 tanycyte (Mmus) [Term] id: CL:4307064 name: Tanycyte NN_1 Glp1r tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Glp1r (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Glp1r. These cells are located in the Hypothalamus, brain , in or close to the regions: Anteroventral periventricular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5244 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5244 Tanycyte NN_1" EXACT [] synonym: "C230072F16Rik (Mmus), Glp1r (Mmus) expressing tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4301602 ! Tanycyte NN_1 tanycyte (Mmus) [Term] id: CL:4307065 name: Tanycyte NN_2 Mylk3 alpha1-tanycyte (Mmus) def: "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5245 Tanycyte NN_2" EXACT [] synonym: "Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus) expressing alpha1-tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:1100001 ! secretory epithelial cell is_a: CL:4042017 ! alpha1-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8"} ! capable of glutamate secretion, neurotransmission [Term] id: CL:4307066 name: Tanycyte NN_2 Mroh5 alpha1-tanycyte (Mmus) def: "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mroh5. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5246 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5246 Tanycyte NN_2" EXACT [] synonym: "Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus) expressing alpha1-tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4042017 ! alpha1-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) [Term] id: CL:4307067 name: alpha2-tanycyte (Mmus) def: "A alpha2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Dscaml1, P3h2. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5247 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5247 Tanycyte NN_2" EXACT [] synonym: "Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus) expressing alpha2-tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4042018 ! alpha2-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) [Term] id: CL:4307068 name: Tanycyte NN_2 Otx2 tanycyte (Mmus) def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Otx2, Nkx2-4. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5248 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5248 Tanycyte NN_2" EXACT [] synonym: "Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus) expressing tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) [Term] id: CL:4307069 name: beta1-tancyte (Mmus) def: "A beta1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Col25a1, C230072F16Rik. These cells are located in the Hypothalamus, brain , in or close to the regions: third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5249 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "5249 Tanycyte NN_2" EXACT [] synonym: "Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus) expressing beta1-tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4042019 ! beta1-tanycyte is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus) [Term] id: CL:4307070 name: beta-2 tanycyte (Mmus) def: "A beta2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fndc3c1 (Mmus), Ecrg4 (Mmus). It is distinguished from other Tanycyte NN cells by expression of Ecrg4. These cells are located in the Hypothalamus, brain , in or close to the regions: Median eminence, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5250 Tanycyte NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1174 Tanycyte NN_3" EXACT [] synonym: "5250 Tanycyte NN_3" EXACT [] synonym: "Fndc3c1 (Mmus), Ecrg4 (Mmus) expressing beta2-tanycyte of brain (Mus musculus)" EXACT [] is_a: CL:4042020 ! beta2-tanycyte is_a: CL:4300362 ! tanycyte (Mmus) [Term] id: CL:4307083 name: hypendemal cell (Mmus) def: "A hypendymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sspo (Mmus), Wfdc2 (Mmus). It is distinguished from other Astro-Epen cells by expression of Sspo, Wfdc2. These cells are located in the Midbrain, brain , in or close to the regions: third ventricle, posterior commissure, Subcommissural organ . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5263 Hypendymal NN_1." [doi:10.3389/fncel.2015.00480, https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "1177 Hypendymal NN_1" EXACT [] synonym: "324 Hypendymal NN" EXACT [] synonym: "5263 Hypendymal NN_1" EXACT [] synonym: "Sspo (Mmus), Wfdc2 (Mmus) expressing hypendymal cell of brain (Mus musculus)" EXACT [] is_a: CL:4023181 ! hypendymal cell [Term] id: CL:4307084 name: CHOR NN_1 Tbc1d1 choroid plexus epithelial cell (Mmus) def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Tbc1d1 (Mmus). It is distinguished from other CHOR NN cells by expression of Tbc1d1. These cells are located in the Cerebellum, brain , in or close to the regions: Paraflocculus, choroid plexus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5264 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "2900040C04Rik (Mmus), Tbc1d1 (Mmus) expressing choroid plexus epithelial cell of brain (Mus musculus)" EXACT [] synonym: "5264 CHOR NN_1" EXACT [] is_a: CL:4301608 ! choroid plexus epithelial cell (Mmus) [Term] id: CL:4307085 name: CHOR NN_1 Slc17a8 choroid plexus epithelial cell (Mmus) def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic. These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: human_subset subset: mouse_subset synonym: "2900040C04Rik (Mmus), Slc17a8 (Mmus) expressing choroid plexus epithelial cell of brain (Mus musculus)" EXACT [] synonym: "5265 CHOR NN_1" EXACT [] is_a: CL:0000686 ! cerebrospinal fluid secreting cell is_a: CL:4301608 ! choroid plexus epithelial cell (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8"} ! capable of glutamate secretion, neurotransmission [Term] id: CL:4307086 name: OPC NN_1 Neil3 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Foxg1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5266 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5266 OPC NN_1" EXACT [] synonym: "Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) [Term] id: CL:4307087 name: OPC NN_1 Irx2 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Irx2. These cells are located in the Cerebellum, brain, Midbrain, Pons, Medulla . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5267 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5267 OPC NN_1" EXACT [] synonym: "Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) [Term] id: CL:4307088 name: OPC NN_1 Mms22l oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus). It is distinguished from other OPC NN_1 cells by expression of Mms22l, Foxg1, Top2a. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5268 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5268 OPC NN_1" EXACT [] synonym: "Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) [Term] id: CL:4307089 name: OPC NN_1 Col27a1 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Col27a1. These cells are located in the Midbrain, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5269 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5269 OPC NN_1" EXACT [] synonym: "Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) [Term] id: CL:4307090 name: OPC NN_1 Rmi2 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Rmi2, Col27a1. These cells are located in the Hypothalamus, Midbrain, Pallidum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5270 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5270 OPC NN_1" EXACT [] synonym: "Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) [Term] id: CL:4307091 name: OPC NN_2 oligodendrocyte precursor cell (Mmus) def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus). It is distinguished from other OPC NN cells by expression of Cenpa. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5271 OPC NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1180 OPC NN_2" EXACT [] synonym: "5271 OPC NN_2" EXACT [] synonym: "Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus) expressing oligodendrocyte precursor cell of brain (Mus musculus)" EXACT [] is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus) [Term] id: CL:4307092 name: COP NN_1 Rgcc committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, Plpp4. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5272 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5272 COP NN_1" EXACT [] synonym: "Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) [Term] id: CL:4307093 name: COP NN_1 9130019P16Rik committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, 9130019P16Rik. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5273 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5273 COP NN_1" EXACT [] synonym: "Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) [Term] id: CL:4307094 name: COP NN_1 C1ql1 committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus). It is distinguished from other COP NN_1 cells by expression of C1ql1, Gstp1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5274 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5274 COP NN_1" EXACT [] synonym: "Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) [Term] id: CL:4307095 name: COP NN_1 Bmp4 committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Mob3b. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5275 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5275 COP NN_1" EXACT [] synonym: "9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) [Term] id: CL:4307096 name: COP NN_1 Vwc2 committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus). It is distinguished from other COP NN_1 cells by expression of Vwc2, Opalin. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5276 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5276 COP NN_1" EXACT [] synonym: "9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) [Term] id: CL:4307097 name: COP NN_1 Cck committed oligodendrocyte precursor (Mmus) def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Cck, Ptger1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5277 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5277 COP NN_1" EXACT [] synonym: "9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus) expressing committed oligodendrocyte precursor of brain (Mus musculus)" EXACT [] is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus) [Term] id: CL:4307098 name: NFOL NN_2 9630013A20Rik newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Grin2b (Mmus). It is distinguished from other NFOL NN_2 cells by expression of 9630013A20Rik, Grin2b. These cells are located in the Midbrain, Thalamus, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5278 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5278 NFOL NN_2" EXACT [] synonym: "9630013A20Rik (Mmus), Grin2b (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) [Term] id: CL:4307099 name: NFOL NN_2 Dbx2 newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Dbx2, Rassf10. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5279 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5279 NFOL NN_2" EXACT [] synonym: "9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) [Term] id: CL:4307100 name: NFOL NN_2 Rgs16 newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Rgs16, Rhbdl2. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5280 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5280 NFOL NN_2" EXACT [] synonym: "9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) [Term] id: CL:4307101 name: NFOL NN_2 Il23a newly formed oligodendrocyte (Mmus) def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Il23a, Opalin, Ptprb. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5281 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5281 NFOL NN_2" EXACT [] synonym: "9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus) expressing newly formed oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus) [Term] id: CL:4307102 name: MFOL NN_3 Cxcl12 myelin-forming oligodendrocyte (Mmus) def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Cxcl12, Efhd1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5282 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5282 MFOL NN_3" EXACT [] synonym: "Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus) expressing myelin-forming oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301613 ! myelin-forming oligodendrocyte (Mmus) [Term] id: CL:4307103 name: MFOL NN_3 Il23a myelin-forming oligodendrocyte (Mmus) def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Il23a, Ppp1r14a. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5283 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5283 MFOL NN_3" EXACT [] synonym: "9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus) expressing myelin-forming oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301613 ! myelin-forming oligodendrocyte (Mmus) [Term] id: CL:4307104 name: MOL NN_4 Plin3 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Plin3, Grm7. These cells are located in the Medulla, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5284 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5284 MOL NN_4" EXACT [] synonym: "Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) [Term] id: CL:4307105 name: MOL NN_4 Spock3 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus). It is distinguished from other MOL NN_4 cells by expression of Spock3, Rhoj. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5285 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5285 MOL NN_4" EXACT [] synonym: "Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) [Term] id: CL:4307106 name: MOL NN_4 Art3 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Art3. These cells are located in the Medulla, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5286 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5286 MOL NN_4" EXACT [] synonym: "Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) [Term] id: CL:4307107 name: MOL NN_4 Il33 mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Il33, Gm5087. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5287 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5287 MOL NN_4" EXACT [] synonym: "Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) [Term] id: CL:4307108 name: MOL NN_4 Sspo mature myelinating oligodendrocyte (Mmus) def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mog (Mmus), Anln (Mmus), Gm32633 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Sspo, Selenop. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5288 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5288 MOL NN_4" EXACT [] synonym: "Mog (Mmus), Anln (Mmus), Gm32633 (Mmus) expressing mature myelinating oligodendrocyte of brain (Mus musculus)" EXACT [] is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus) [Term] id: CL:4307109 name: OEC NN_1 Adamts12 olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn5 (Mmus), Adamts12 (Mmus). It is distinguished from other OEC cells by expression of Adamts12. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5289 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5289 OEC NN_1" EXACT [] synonym: "Cldn5 (Mmus), Adamts12 (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" EXACT [] is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) [Term] id: CL:4307110 name: OEC NN_1 Gdpd4 olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus). It is distinguished from other OEC cells by expression of Gdpd4, Cldn5. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5290 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5290 OEC NN_1" EXACT [] synonym: "Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" EXACT [] is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) [Term] id: CL:4307111 name: OEC NN_1 A330076C08Rik olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus). It is distinguished from other OEC cells by expression of A330076C08Rik. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5291 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5291 OEC NN_1" EXACT [] synonym: "Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" EXACT [] is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) [Term] id: CL:4307112 name: OEC NN_1 Rasgef1c olfactory ensheathing cell (Mmus) def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5292 OEC NN_1" EXACT [] synonym: "Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus) expressing olfactory ensheathing cell of brain (Mus musculus)" EXACT [] is_a: CL:0000151 ! secretory cell is_a: CL:4301615 ! olfactory ensheathing cell (Mmus) relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a7"} ! capable of glutamate secretion, neurotransmission [Term] id: CL:4307113 name: ABC NN_1 Pde11a arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Pde11a (Mmus). It is distinguished from other ABC NN cells by expression of Pde11a. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5293 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5293 ABC NN_1" EXACT [] synonym: "Slc47a1 (Mmus), Pde11a (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" EXACT [] is_a: CL:4301616 ! arachnoid barrier cell (Mmus) [Term] id: CL:4307114 name: ABC NN_1 Dapl1 arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Dapl1 (Mmus). It is distinguished from other ABC NN cells by expression of Dapl1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5294 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5294 ABC NN_1" EXACT [] synonym: "Slc47a1 (Mmus), Dapl1 (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" EXACT [] is_a: CL:4301616 ! arachnoid barrier cell (Mmus) [Term] id: CL:4307115 name: ABC NN_1 Cubn arachnoid barrier cell (Mmus) def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prg4 (Mmus), Cubn (Mmus). It is distinguished from other ABC NN cells by expression of Cubn. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5295 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5295 ABC NN_1" EXACT [] synonym: "Prg4 (Mmus), Cubn (Mmus) expressing arachnoid barrier cell of brain (Mus musculus)" EXACT [] is_a: CL:4301616 ! arachnoid barrier cell (Mmus) [Term] id: CL:4307132 name: microglial cell (Mmus) def: "A microglial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C1qa (Mmus), Tmem119 (Mmus). It is distinguished from other Immune cells by expression of C1qa, Tmem119. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5312 Microglia NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "1194 Microglia NN_1" EXACT [] synonym: "334 Microglia NN" EXACT [] synonym: "5312 Microglia NN_1" EXACT [] synonym: "C1qa (Mmus), Tmem119 (Mmus) expressing microglial cell of brain (Mus musculus)" EXACT [] is_a: CL:0000129 ! microglial cell relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus [Term] id: CL:4307133 name: BAM NN_1 Mrc1 border associated macrophage (Mmus) def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus). It is distinguished from other BAM NN cells by expression of Mrc1, Pf4. These cells are located in the Medulla, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5313 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5313 BAM NN_1" EXACT [] synonym: "Mrc1 (Mmus), Pf4 (Mmus) expressing border associated macrophage of brain (Mus musculus)" EXACT [] is_a: CL:4301625 ! border associated macrophage (Mmus) [Term] id: CL:4307134 name: BAM NN_1 Fos border associated macrophage (Mmus) def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus). It is distinguished from other BAM NN cells by expression of Fos. These cells are located in the Isocortex, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5314 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z] subset: mouse_subset synonym: "5314 BAM NN_1" EXACT [] synonym: "Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus) expressing border associated macrophage of brain (Mus musculus)" EXACT [] is_a: CL:4301625 ! border associated macrophage (Mmus) [Term] id: CLM:1000043 name: NS forest marker set of pulmonary neuroendocrine cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100604 ! has part CHGA relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000134443 ! has part GRP [Term] id: CLM:1000056 name: NS forest marker set of tracheobronchial smooth muscle cell (Human lung). is_a: SO:0001260 ! sequence_collection relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000107796 ! has part ACTA2 relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000149591 ! has part TAGLN [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution intersection_of: GO:0048308 ! organelle inheritance intersection_of: GOREL:0002003 GO:0005739 ! results in distribution of mitochondrion relationship: GOREL:0002003 GO:0005739 ! results in distribution of mitochondrion [Term] id: GO:0000003 name: obsolete reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] comment: The reason for obsoletion is that this term is equivalent to reproductive process. synonym: "reproductive physiological process" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: GOREL:0002003 GO:0005773 ! results in distribution of vacuole relationship: GOREL:0002003 GO:0005773 ! results in distribution of vacuole [Term] id: GO:0000045 name: autophagosome assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0070925 ! organelle assembly is_a: GO:1905037 ! autophagosome organization relationship: BFO:0000051 GO:0019778 ! has part Atg12 activating enzyme activity relationship: BFO:0000051 GO:0019786 ! has part protein-phosphatidylethanolamide deconjugating activity relationship: BFO:0000051 GO:0061651 ! has part Atg12 conjugating enzyme activity relationship: BFO:0000051 GO:0061660 ! has part Atg12 ligase activity relationship: BFO:0000051 GO:1904745 ! has part Atg1/ULK1 kinase complex assembly [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] xref: Reactome:R-HSA-2500257 "Resolution of Sister Chromatid Cohesion" is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: BFO:0000050 GO:0140014 ! part of mitotic nuclear division relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] synonym: "Golgi apparatus membrane" EXACT [] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus relationship: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0042645 ! part of mitochondrial nucleoid [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0005739 ! results in fission of mitochondrion relationship: GOREL:0002004 GO:0005739 ! results in fission of mitochondrion [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18154 ! has primary output polysaccharide relationship: RO:0004008 CHEBI:18154 ! has primary output polysaccharide [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Reactome:R-HSA-69278 "Cell Cycle, Mitotic" xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: BFO:0000051 GO:0140014 ! has part mitotic nuclear division relationship: BFO:0000051 GO:0140014 ! has part mitotic nuclear division [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0005634 ! results in fission of nucleus relationship: GOREL:0002004 GO:0005634 ! results in fission of nucleus [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:26523 ! has primary input reactive oxygen species relationship: RO:0004009 CHEBI:26523 ! has primary input reactive oxygen species [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0043226 ! part of organelle relationship: BFO:0000050 GO:0043226 ! part of organelle [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane [Term] id: GO:0000741 name: karyogamy namespace: biological_process def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion intersection_of: RO:0012008 GO:0005634 ! results in fusion of nucleus relationship: BFO:0000050 GO:0006997 ! part of nucleus organization relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation intersection_of: BFO:0000051 GO:0045026 ! has part plasma membrane fusion [Term] id: GO:0000785 name: chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] synonym: "cytoplasmic chromatin" NARROW [] synonym: "nuclear chromatin" NARROW [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005694 ! part of chromosome [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] synonym: "nuclear euchromatin" RELATED [] synonym: "transcriptionally active chromatin" EXACT [] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] synonym: "nuclear heterochromatin" NARROW [] synonym: "transcriptionally inactive chromatin" EXACT [] synonym: "transcriptionally silent chromatin" EXACT [] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome relationship: RO:0002216 GO:0007530 ! capable of part of sex determination [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000820 name: regulation of glutamine family amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] synonym: "regulation of glutamine family amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009064 ! regulates glutamine family amino acid metabolic process relationship: RO:0002211 GO:0009064 ! regulates glutamine family amino acid metabolic process [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] xref: Reactome:R-HSA-9836573 "Mitochondrial RNA degradation" is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process intersection_of: GO:0006401 ! RNA catabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process intersection_of: GO:0016070 ! RNA metabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000957 ! regulates mitochondrial RNA catabolic process relationship: RO:0002211 GO:0000957 ! regulates mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:1902369 ! negative regulation of RNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000957 ! negatively regulates mitochondrial RNA catabolic process relationship: RO:0002212 GO:0000957 ! negatively regulates mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000957 ! positively regulates mitochondrial RNA catabolic process relationship: RO:0002213 GO:0000957 ! positively regulates mitochondrial RNA catabolic process [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001402 name: signal transduction involved in filamentous growth namespace: biological_process def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000050 GO:0030447 ! part of filamentous growth relationship: BFO:0000050 GO:0030447 ! part of filamentous growth [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal system [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process intersection_of: GO:0032501 ! multicellular organismal process intersection_of: RO:0002297 UBERON:0001474 ! results in formation of bone element relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002297 UBERON:0001474 ! results in formation of bone element [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process intersection_of: GO:0006581 ! acetylcholine catabolic process intersection_of: BFO:0000066 GO:0043083 ! occurs in synaptic cleft relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic relationship: BFO:0000066 GO:0043083 ! occurs in synaptic cleft [Term] id: GO:0001508 name: action potential namespace: biological_process def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "ciliary or bacterial-type flagellar motility" RELATED [] synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000023 ! results in growth of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002343 CL:0000023 ! results in growth of oocyte [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000023 ! results in maturation of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016049 ! regulates cell growth relationship: RO:0002211 GO:0016049 ! regulates cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel relationship: BFO:0000050 GO:0001944 ! part of vasculature development relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis namespace: biological_process def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "patterning of blood vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: BFO:0000050 GO:0001525 ! part of angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: RO:0000057 GO:0005874 ! has participant microtubule relationship: RO:0002297 GO:0097427 ! results in formation of microtubule bundle [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: GO:0038023 ! signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: BFO:0000051 GO:0042277 ! has part peptide binding relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0001654 name: eye development namespace: biological_process def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye relationship: BFO:0000050 GO:0150063 ! part of visual system development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0000970 ! results in development of eye [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal-level homeostasis [Term] id: GO:0001664 name: G protein-coupled receptor binding namespace: molecular_function def: "Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein coupled receptor binding" EXACT [GOC:bf] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer" is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to intermittent hypoxia" NARROW [] synonym: "response to lowered oxygen tension" EXACT [] synonym: "response to sustained hypoxia" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000021 ! part of female germ cell relationship: BFO:0000050 CL:0000021 ! part of female germ cell [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex relationship: BFO:0000050 GO:0006413 ! part of translational initiation relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000923 ! results in formation of germ layer relationship: BFO:0000050 GO:0007369 ! part of gastrulation relationship: RO:0002297 UBERON:0000923 ! results in formation of germ layer [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000924 ! results in formation of ectoderm relationship: BFO:0000050 GO:0007398 ! part of ectoderm development relationship: RO:0002297 UBERON:0000924 ! results in formation of ectoderm [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9823730 "Formation of definitive endoderm" is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000925 ! results in formation of endoderm relationship: BFO:0000050 GO:0007492 ! part of endoderm development relationship: RO:0002297 UBERON:0000925 ! results in formation of endoderm [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000926 ! results in formation of mesoderm relationship: BFO:0000050 GO:0048332 ! part of mesoderm morphogenesis relationship: RO:0002297 UBERON:0000926 ! results in formation of mesoderm [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732] is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: BFO:0000050 GO:0000803 ! part of sex chromosome relationship: BFO:0000050 GO:0000803 ! part of sex chromosome [Term] id: GO:0001743 name: lens placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] synonym: "optic placode formation" RELATED [] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003073 ! results in formation of lens placode relationship: BFO:0000050 GO:0048598 ! part of embryonic morphogenesis relationship: RO:0002297 UBERON:0003073 ! results in formation of lens placode [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye relationship: BFO:0000050 GO:0048749 ! part of compound eye development relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell relationship: BFO:0000050 GO:0048592 ! part of eye morphogenesis relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell relationship: BFO:0000050 GO:0014032 ! part of neural crest cell development relationship: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] xref: Reactome:R-HSA-9824272 "Somitogenesis" xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002329 ! results in formation of somite relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002297 UBERON:0002329 ! results in formation of somite [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] synonym: "neuron chemotaxis" EXACT [] synonym: "neuron guidance" RELATED [] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000540 ! results in movement of neuron relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0002565 CL:0000540 ! results in movement of neuron [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte relationship: BFO:0000050 GO:0046649 ! part of lymphocyte activation relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000050 GO:0042110 ! part of T cell activation relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell relationship: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0002269 ! leukocyte activation involved in inflammatory response is_a: GO:0042116 ! macrophage activation is_a: GO:0061900 ! glial cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000129 ! has primary input microglial cell relationship: RO:0004009 CL:0000129 ! has primary input microglial cell [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0032501 ! multicellular organismal process relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0042592 ! part of homeostatic process intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell relationship: BFO:0000050 GO:0043029 ! part of T cell homeostasis [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cytokine biosynthetic process" NARROW [] synonym: "cytokine metabolic process" NARROW [] synonym: "cytokine secretion" NARROW [] synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interferon secretion" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0010467 ! gene expression is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "regulation of cytokine anabolism" EXACT [] synonym: "regulation of cytokine biosynthesis" EXACT [] synonym: "regulation of cytokine biosynthetic process" NARROW [] synonym: "regulation of cytokine formation" EXACT [] synonym: "regulation of cytokine secretion" NARROW [] synonym: "regulation of cytokine synthesis" EXACT [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001816 ! regulates cytokine production relationship: RO:0002211 GO:0001816 ! regulates cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "down regulation of cytokine biosynthetic process" EXACT [] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine biosynthetic process" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine biosynthetic process" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine biosynthetic process" NARROW [] synonym: "inhibition of cytokine production" NARROW [] synonym: "negative regulation of cytokine anabolism" EXACT [] synonym: "negative regulation of cytokine biosynthesis" EXACT [] synonym: "negative regulation of cytokine biosynthetic process" NARROW [] synonym: "negative regulation of cytokine formation" EXACT [] synonym: "negative regulation of cytokine secretion" NARROW [] synonym: "negative regulation of cytokine synthesis" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001816 ! negatively regulates cytokine production relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "activation of cytokine production" NARROW [] synonym: "positive regulation of cytokine biosynthetic process" NARROW [] synonym: "positive regulation of cytokine secretion" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001816 ! positively regulates cytokine production relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. synonym: "blastula development" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst relationship: BFO:0000050 GO:0001701 ! part of in utero embryonic development relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. synonym: "blastula formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000358 ! results in formation of blastocyst relationship: BFO:0000050 GO:0001824 ! part of blastocyst development relationship: RO:0002297 UBERON:0000358 ! results in formation of blastocyst [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell relationship: BFO:0000050 GO:0001825 ! part of blastocyst formation relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell relationship: BFO:0000050 GO:0001825 ! part of blastocyst formation relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell relationship: BFO:0000050 GO:0001829 ! part of trophectodermal cell differentiation relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. synonym: "blastula growth" RELATED [] is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst relationship: BFO:0000050 GO:0001824 ! part of blastocyst development relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell relationship: BFO:0000050 GO:0001832 ! part of blastocyst growth relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell relationship: BFO:0000050 GO:0001832 ! part of blastocyst growth relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] xref: Reactome:R-HSA-9758919 "Epithelial-Mesenchymal Transition (EMT) during gastrulation" is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell intersection_of: RO:0004009 CL:0000066 ! has primary input epithelial cell relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: BFO:0000050 GO:0016331 ! part of morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate relationship: BFO:0000050 GO:0001840 ! part of neural plate development relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate [Term] id: GO:0001841 name: neural tube formation namespace: biological_process def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001049 ! results in formation of neural tube relationship: BFO:0000050 GO:0021915 ! part of neural tube development relationship: RO:0002297 UBERON:0001049 ! results in formation of neural tube [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005062 ! results in formation of neural fold relationship: BFO:0000050 GO:0014020 ! part of primary neural tube formation relationship: RO:0002297 UBERON:0005062 ! results in formation of neural fold [Term] id: GO:0001873 name: polysaccharide immune receptor activity namespace: molecular_function def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091] synonym: "polysaccharide receptor activity" BROAD [] is_a: GO:0038187 ! pattern recognition receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: BFO:0000051 GO:0030247 ! has part polysaccharide binding relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell relationship: BFO:0000050 GO:0045446 ! part of endothelial cell differentiation relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell relationship: BFO:0000050 GO:0001885 ! part of endothelial cell development relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: BFO:0000050 GO:0048871 ! part of multicellular organismal-level homeostasis [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] subset: gocheck_obsoletion_candidate synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006468 ! regulates protein phosphorylation relationship: RO:0002211 GO:0006468 ! regulates protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gocheck_obsoletion_candidate synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation relationship: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gocheck_obsoletion_candidate synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation relationship: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation relationship: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr] synonym: "post-synaptic membrane organization" EXACT [] synonym: "postsynaptic membrane organisation" EXACT [] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane relationship: BFO:0000050 GO:0099173 ! part of postsynapse organization relationship: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature relationship: BFO:0000050 GO:0072359 ! part of circulatory system development relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion relationship: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] synonym: "intramembranous bone ossification" RELATED [GOC:cjm] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] xref: Reactome:R-HSA-8939247 "RUNX1 regulates transcription of genes involved in interleukin signaling" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019221 ! regulates cytokine-mediated signaling pathway relationship: RO:0002211 GO:0019221 ! regulates cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060761 ! negative regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway relationship: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060760 ! positive regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway relationship: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway [Term] id: GO:0001976 name: nervous system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure relationship: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium relationship: BFO:0000050 GO:0060429 ! part of epithelium development relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002036 name: regulation of L-glutamate import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] synonym: "regulation of L-glutamate transport" BROAD [] synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0032890 ! regulation of organic acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098712 ! regulates L-glutamate import across plasma membrane relationship: RO:0002211 GO:0098712 ! regulates L-glutamate import across plasma membrane creation_date: 2012-06-13T07:34:08Z [Term] id: GO:0002037 name: negative regulation of L-glutamate import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamate transport" BROAD [] synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamate transport" BROAD [] synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamate transport" BROAD [] synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamate transport" NARROW [] synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of L-glutamate import" BROAD [] synonym: "negative regulation of L-glutamate transport" BROAD [] synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane relationship: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane creation_date: 2012-06-13T07:34:30Z [Term] id: GO:0002038 name: positive regulation of L-glutamate import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie] synonym: "activation of L-glutamate transport" NARROW [] synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of L-glutamate import" BROAD [] synonym: "positive regulation of L-glutamate transport" BROAD [] synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamate transport" BROAD [] synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamate transport" BROAD [] synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane relationship: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane creation_date: 2012-06-13T07:34:38Z [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte relationship: BFO:0000050 GO:0051216 ! part of cartilage development relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte relationship: BFO:0000050 GO:0002062 ! part of chondrocyte differentiation relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell relationship: BFO:0000050 GO:0030855 ! part of epithelial cell differentiation relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell relationship: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell relationship: BFO:0000050 GO:0002065 ! part of columnar/cuboidal epithelial cell differentiation relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell relationship: BFO:0000050 GO:0002067 ! part of glandular epithelial cell differentiation relationship: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell relationship: BFO:0000050 GO:0002066 ! part of columnar/cuboidal epithelial cell development relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell relationship: BFO:0000050 GO:0002064 ! part of epithelial cell development relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell relationship: BFO:0000050 GO:0002068 ! part of glandular epithelial cell development relationship: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup relationship: BFO:0000050 GO:0060900 ! part of embryonic camera-type eye formation relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT [] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye relationship: BFO:0000050 GO:0002088 ! part of lens development in camera-type eye relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000092 ! acts on population of osteoclast relationship: RO:0012003 CL:0000092 ! acts on population of osteoclast creation_date: 2010-02-03T01:50:37Z [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. subset: goslim_generic subset: goslim_pombe subset: goslim_yeast is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome relationship: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome creation_date: 2011-06-09T03:11:53Z [Term] id: GO:0002182 name: cytoplasmic translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] is_a: GO:0006414 ! translational elongation intersection_of: GO:0006414 ! translational elongation intersection_of: BFO:0000050 GO:0002181 ! part of cytoplasmic translation relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation creation_date: 2011-06-09T03:14:42Z [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation intersection_of: GO:0006413 ! translational initiation intersection_of: BFO:0000050 GO:0002181 ! part of cytoplasmic translation relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation creation_date: 2011-06-09T03:15:48Z [Term] id: GO:0002184 name: cytoplasmic translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] is_a: GO:0006415 ! translational termination intersection_of: GO:0006415 ! translational termination intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation relationship: BFO:0000066 GO:0005829 ! occurs in cytosol creation_date: 2011-06-09T03:17:13Z [Term] id: GO:0002213 name: defense response to insect namespace: biological_process def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:50557 ! has primary input Insecta relationship: RO:0004009 NCBITaxon:50557 ! has primary input Insecta [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response intersection_of: GO:0045087 ! innate immune response intersection_of: BFO:0000066 UBERON:0000344 ! occurs in mucosa relationship: BFO:0000066 UBERON:0000344 ! occurs in mucosa relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "acquired immune response" EXACT [ISBN:068340007X] synonym: "immune memory response" EXACT [GOC:add] xref: Reactome:R-HSA-1280218 "Adaptive Immune System" xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000763 ! acts on population of myeloid cell relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation intersection_of: GO:0042118 ! endothelial cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation intersection_of: GO:0048143 ! astrocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte relationship: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response intersection_of: GO:0001773 ! myeloid dendritic cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation intersection_of: GO:0042117 ! monocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "macrophage activation during immune response" RELATED [GOC:tb] synonym: "macrophage polarization involved in immune response" EXACT [] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0042116 ! macrophage activation intersection_of: GO:0042116 ! macrophage activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0002275 ! part of myeloid cell activation involved in immune response [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response intersection_of: GO:0001774 ! microglial cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation intersection_of: GO:0042110 ! T cell activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development involved in immune response" RELATED [GOC:add] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030217 ! T cell differentiation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0042098 ! T cell proliferation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell relationship: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "cytokine biosynthetic process involved in immune response" NARROW [] synonym: "cytokine production during immune response" RELATED [GOC:dph] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] synonym: "cytokine secretion involved in immune response" RELATED [] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000451 ! process has causal agent dendritic cell relationship: RO:0002608 CL:0000451 ! process has causal agent dendritic cell [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0061082 ! myeloid leukocyte cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell relationship: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, ISBN:0781735149] synonym: "immune response in MALT" NARROW [] synonym: "immune response in mucosal-associated lymphoid tissue" NARROW [] synonym: "immune response in urogenital tract" NARROW [] is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex relationship: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex relationship: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell relationship: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process is_a: GO:0010467 ! gene expression [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion intersection_of: GO:0001820 ! serotonin secretion intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0002351 ! part of serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000542 ! process has causal agent lymphocyte relationship: RO:0002608 CL:0000542 ! process has causal agent lymphocyte [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell relationship: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000050 GO:0002456 ! part of T cell mediated immunity relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell relationship: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000576 ! occurs in monocyte relationship: BFO:0000066 CL:0000576 ! occurs in monocyte [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002405 ! results in development of immune system relationship: RO:0002296 UBERON:0002405 ! results in development of immune system [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: BFO:0000050 GO:0006955 ! part of immune response relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] subset: gocheck_do_not_annotate synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000576 ! results in movement of monocyte relationship: RO:0002565 CL:0000576 ! results in movement of monocyte [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] synonym: "pro-T lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell relationship: BFO:0000050 GO:0030217 ! part of T cell differentiation relationship: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019882 ! regulates antigen processing and presentation relationship: RO:0002211 GO:0019882 ! regulates antigen processing and presentation [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation relationship: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation relationship: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation relationship: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation relationship: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation relationship: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation relationship: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation relationship: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation relationship: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation relationship: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation relationship: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation relationship: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation relationship: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation relationship: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation relationship: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002457 ! regulates T cell antigen processing and presentation relationship: RO:0002211 GO:0002457 ! regulates T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002710 ! negative regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation relationship: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002711 ! positive regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation relationship: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst intersection_of: GO:0045730 ! respiratory burst intersection_of: BFO:0000050 GO:0006952 ! part of defense response relationship: BFO:0000050 GO:0006952 ! part of defense response [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002376 ! regulates immune system process relationship: RO:0002211 GO:0002376 ! regulates immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002376 ! negatively regulates immune system process relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002376 ! positively regulates immune system process relationship: RO:0002213 GO:0002376 ! positively regulates immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050900 ! regulates leukocyte migration relationship: RO:0002211 GO:0050900 ! regulates leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration relationship: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050900 ! positively regulates leukocyte migration relationship: RO:0002213 GO:0050900 ! positively regulates leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis relationship: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis relationship: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis relationship: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045321 ! regulates leukocyte activation relationship: RO:0002211 GO:0045321 ! regulates leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation relationship: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045321 ! positively regulates leukocyte activation relationship: RO:0002213 GO:0045321 ! positively regulates leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002252 ! regulates immune effector process relationship: RO:0002211 GO:0002252 ! regulates immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002252 ! negatively regulates immune effector process relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002252 ! positively regulates immune effector process relationship: RO:0002213 GO:0002252 ! positively regulates immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response relationship: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010629 ! negative regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010628 ! positive regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response relationship: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity relationship: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity relationship: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity relationship: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity relationship: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002456 ! regulates T cell mediated immunity relationship: RO:0002211 GO:0002456 ! regulates T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity relationship: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity relationship: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response relationship: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "negative regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "positive regulation of cytokine secretion involved in immune response" NARROW [] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002369 ! regulates T cell cytokine production relationship: RO:0002211 GO:0002369 ! regulates T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production relationship: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production relationship: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine production relationship: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production relationship: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production relationship: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine production relationship: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production relationship: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production relationship: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation relationship: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002790 ! regulates peptide secretion relationship: RO:0002211 GO:0002790 ! regulates peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002790 ! negatively regulates peptide secretion relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002790 ! positively regulates peptide secretion relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002250 ! regulates adaptive immune response relationship: RO:0002211 GO:0002250 ! regulates adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response relationship: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002250 ! positively regulates adaptive immune response relationship: RO:0002213 GO:0002250 ! positively regulates adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009607 ! regulates response to biotic stimulus relationship: RO:0002211 GO:0009607 ! regulates response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity relationship: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath relationship: BFO:0000050 GO:0035989 ! part of tendon development relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheath creation_date: 2012-04-23T02:11:22Z [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0022414 ! reproductive process intersection_of: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: BFO:0000050 GO:0050881 ! part of musculoskeletal movement relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] subset: goslim_drosophila subset: goslim_generic synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] subset: goslim_generic synonym: "respiratory gaseous exchange" EXACT [] is_a: GO:0003008 ! system process relationship: BFO:0000050 GO:0007585 ! part of respiratory gaseous exchange by respiratory system [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell relationship: RO:0002231 CL:0000222 ! has start location mesodermal cell relationship: RO:0002232 CL:0000223 ! has end location endodermal cell creation_date: 2009-09-22T03:07:34Z [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell intersection_of: RO:0002232 CL:0000222 ! has end location mesodermal cell relationship: RO:0002231 CL:0000223 ! has start location endodermal cell relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell creation_date: 2009-09-22T03:10:29Z [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate creation_date: 2009-09-22T04:12:18Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0035050 ! part of embryonic heart tube development relationship: BFO:0000050 GO:0048562 ! part of embryonic organ morphogenesis relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004141 ! results in formation of heart tube relationship: BFO:0000050 GO:0003143 ! part of embryonic heart tube morphogenesis relationship: RO:0002297 UBERON:0004141 ! results in formation of heart tube creation_date: 2009-09-22T04:22:34Z [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation creation_date: 2009-09-22T04:26:03Z [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0060914 ! part of heart formation relationship: BFO:0000050 GO:0061308 ! part of cardiac neural crest cell development involved in heart development creation_date: 2009-09-22T04:29:55Z [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum creation_date: 2009-09-22T07:51:01Z [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part relationship: BFO:0000050 GO:0060412 ! part of ventricular septum morphogenesis relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part creation_date: 2009-09-22T07:51:41Z [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part relationship: BFO:0000050 GO:0060412 ! part of ventricular septum morphogenesis relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part creation_date: 2009-09-22T07:53:28Z [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract creation_date: 2009-09-22T07:59:24Z [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: BFO:0000050 GO:0003144 ! part of embryonic heart tube formation relationship: BFO:0000050 GO:0003145 ! part of embryonic heart tube formation via epithelial folding creation_date: 2009-09-23T10:10:24Z [Term] id: GO:0003156 name: regulation of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048645 ! regulates animal organ formation relationship: RO:0002211 GO:0048645 ! regulates animal organ formation creation_date: 2009-09-30T11:21:09Z [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium creation_date: 2009-10-01T12:42:27Z [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium creation_date: 2009-10-01T12:50:57Z [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium relationship: BFO:0000050 GO:0003158 ! part of endothelium development relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium creation_date: 2009-10-01T01:34:06Z [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium relationship: BFO:0000050 GO:0003157 ! part of endocardium development relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium creation_date: 2009-10-01T01:37:26Z [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart relationship: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart creation_date: 2009-10-01T01:57:16Z [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node creation_date: 2009-10-01T02:05:13Z [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node creation_date: 2009-10-01T02:06:09Z [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system creation_date: 2009-10-01T02:07:12Z [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber creation_date: 2009-10-01T02:07:50Z [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte relationship: BFO:0000050 GO:0003165 ! part of Purkinje myocyte development relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte creation_date: 2009-10-01T02:49:54Z [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein creation_date: 2009-10-08T10:45:41Z [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion creation_date: 2009-10-08T01:17:43Z [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003197 ! part of endocardial cushion development relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion creation_date: 2009-10-08T01:43:22Z [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton creation_date: 2009-10-13T09:05:04Z [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber creation_date: 2009-10-13T09:11:18Z [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003205 ! part of cardiac chamber development relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber creation_date: 2009-10-13T09:14:51Z [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004151 ! results in formation of cardiac chamber relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis relationship: RO:0002297 UBERON:0004151 ! results in formation of cardiac chamber creation_date: 2009-10-13T09:29:13Z [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle relationship: BFO:0000050 GO:0003231 ! part of cardiac ventricle development relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle creation_date: 2009-10-13T09:38:44Z [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium relationship: BFO:0000050 GO:0003230 ! part of cardiac atrium development relationship: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium creation_date: 2009-10-13T09:39:44Z [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis relationship: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium creation_date: 2009-10-13T09:44:25Z [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventricle relationship: BFO:0000050 GO:0003208 ! part of cardiac ventricle morphogenesis relationship: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventricle creation_date: 2009-10-13T09:46:27Z [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium relationship: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium creation_date: 2009-10-13T09:48:16Z [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium relationship: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium creation_date: 2009-10-13T09:49:03Z [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle relationship: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle creation_date: 2009-10-13T09:50:08Z [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle relationship: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle creation_date: 2009-10-13T09:50:57Z [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002079 ! results in formation of left cardiac atrium relationship: BFO:0000050 GO:0003212 ! part of cardiac left atrium morphogenesis relationship: RO:0002297 UBERON:0002079 ! results in formation of left cardiac atrium creation_date: 2009-10-13T09:52:31Z [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002078 ! results in formation of right cardiac atrium relationship: BFO:0000050 GO:0003213 ! part of cardiac right atrium morphogenesis relationship: RO:0002297 UBERON:0002078 ! results in formation of right cardiac atrium creation_date: 2009-10-13T09:53:12Z [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002084 ! results in formation of heart left ventricle relationship: BFO:0000050 GO:0003214 ! part of cardiac left ventricle morphogenesis relationship: RO:0002297 UBERON:0002084 ! results in formation of heart left ventricle creation_date: 2009-10-13T09:54:33Z [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002080 ! results in formation of heart right ventricle relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis relationship: RO:0002297 UBERON:0002080 ! results in formation of heart right ventricle creation_date: 2009-10-13T09:55:38Z [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle relationship: BFO:0000050 GO:0003214 ! part of cardiac left ventricle morphogenesis relationship: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle creation_date: 2009-10-13T10:18:05Z [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis relationship: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle creation_date: 2009-10-13T10:26:33Z [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium relationship: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium creation_date: 2009-10-13T10:53:18Z [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle relationship: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle creation_date: 2009-10-13T10:56:01Z [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium relationship: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium creation_date: 2009-10-13T11:02:07Z [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle relationship: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle creation_date: 2009-10-13T11:03:16Z [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002063 ! results in development of sinus venosus relationship: RO:0002296 UBERON:0002063 ! results in development of sinus venosus creation_date: 2009-10-13T11:12:34Z [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus relationship: BFO:0000050 GO:0003235 ! part of sinus venosus development relationship: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus creation_date: 2009-10-13T11:16:52Z [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus relationship: BFO:0000050 GO:0003236 ! part of sinus venosus morphogenesis relationship: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus creation_date: 2009-10-13T11:18:34Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0060419 ! part of heart growth creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0055008 ! part of cardiac muscle tissue morphogenesis creation_date: 2009-10-13T11:44:21Z [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary relationship: BFO:0000050 GO:0060419 ! part of heart growth relationship: BFO:0000050 GO:0060976 ! part of coronary vasculature development relationship: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary creation_date: 2009-10-13T11:53:12Z [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0061309 ! part of cardiac neural crest cell development involved in outflow tract morphogenesis creation_date: 2009-10-13T02:14:16Z [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002664 ! results in movement of cardioblast relationship: RO:0002565 CL:0002664 ! results in movement of cardioblast creation_date: 2009-10-15T01:52:25Z [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002062 ! results in formation of endocardial cushion relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: RO:0002297 UBERON:0002062 ! results in formation of endocardial cushion creation_date: 2009-10-20T08:53:19Z [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0003272 ! part of endocardial cushion formation relationship: BFO:0000050 GO:0003272 ! part of endocardial cushion formation creation_date: 2009-10-20T09:08:44Z [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis creation_date: 2009-10-20T09:30:01Z [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis creation_date: 2009-10-20T09:37:03Z [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002099 ! results in development of cardiac septum relationship: BFO:0000050 GO:0003205 ! part of cardiac chamber development relationship: RO:0002296 UBERON:0002099 ! results in development of cardiac septum creation_date: 2009-10-20T09:45:13Z [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002094 ! results in development of interventricular septum relationship: BFO:0000050 GO:0003231 ! part of cardiac ventricle development relationship: RO:0002296 UBERON:0002094 ! results in development of interventricular septum creation_date: 2009-10-20T10:04:51Z [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002085 ! results in development of interatrial septum relationship: BFO:0000050 GO:0003230 ! part of cardiac atrium development relationship: RO:0002296 UBERON:0002085 ! results in development of interatrial septum creation_date: 2009-10-20T10:10:38Z [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell relationship: BFO:0000050 GO:0003279 ! part of cardiac septum development relationship: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell creation_date: 2009-10-20T11:03:46Z [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy creation_date: 2009-10-22T09:24:51Z [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy creation_date: 2009-10-22T10:33:56Z [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth creation_date: 2009-10-22T10:38:10Z [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004291 ! results in development of heart rudiment relationship: BFO:0000050 GO:0035050 ! part of embryonic heart tube development relationship: RO:0002296 UBERON:0004291 ! results in development of heart rudiment creation_date: 2009-10-27T08:32:40Z [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003313 ! part of heart rudiment development relationship: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment creation_date: 2009-10-27T08:38:04Z [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment relationship: BFO:0000050 GO:0003314 ! part of heart rudiment morphogenesis relationship: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment creation_date: 2009-10-27T08:43:37Z [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion relationship: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion creation_date: 2009-11-02T02:07:40Z [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion relationship: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion creation_date: 2009-11-02T02:11:22Z [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion relationship: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion creation_date: 2009-11-02T02:13:49Z [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003341 name: cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliary motility" RELATED [] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "flagellar motility" RELATED [] synonym: "flagellar movement" NARROW [GOC:bf] synonym: "flagellum movement" NARROW [] synonym: "microtubule-based flagellum movement" EXACT [] is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: RO:0002565 GO:0005929 ! results in movement of cilium intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002565 GO:0005929 ! results in movement of cilium creation_date: 2009-11-24T09:56:26Z [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004160 ! results in development of proepicardium relationship: BFO:0000050 GO:0003343 ! part of septum transversum development relationship: RO:0002296 UBERON:0004160 ! results in development of proepicardium creation_date: 2009-12-01T10:30:17Z [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004161 ! results in development of septum transversum relationship: RO:0002296 UBERON:0004161 ! results in development of septum transversum creation_date: 2009-12-01T10:40:17Z [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium relationship: BFO:0000050 GO:0060039 ! part of pericardium development relationship: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium creation_date: 2009-12-01T10:46:34Z [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell relationship: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell creation_date: 2009-12-01T11:12:05Z [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "regulation of flagellum movement" RELATED [] synonym: "regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003341 ! regulates cilium movement relationship: RO:0002211 GO:0003341 ! regulates cilium movement creation_date: 2009-12-03T10:12:00Z [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "positive regulation of flagellum movement" RELATED [] synonym: "positive regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003341 ! positively regulates cilium movement relationship: RO:0002213 GO:0003341 ! positively regulates cilium movement creation_date: 2009-12-03T10:16:10Z [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "negative regulation of flagellum movement" RELATED [] synonym: "negative regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003341 ! negatively regulates cilium movement relationship: RO:0002212 GO:0003341 ! negatively regulates cilium movement creation_date: 2009-12-03T10:17:47Z [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron relationship: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron creation_date: 2009-12-03T10:34:30Z [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron relationship: BFO:0000050 GO:0003357 ! part of noradrenergic neuron differentiation relationship: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron creation_date: 2009-12-03T10:38:37Z [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002298 ! results in development of brainstem relationship: RO:0002296 UBERON:0002298 ! results in development of brainstem creation_date: 2009-12-03T10:47:20Z [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation intersection_of: GO:0003357 ! noradrenergic neuron differentiation intersection_of: BFO:0000050 GO:0003360 ! part of brainstem development relationship: BFO:0000050 GO:0003360 ! part of brainstem development creation_date: 2009-12-03T10:53:30Z [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration relationship: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration creation_date: 2009-12-08T04:50:41Z [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration creation_date: 2009-12-08T05:42:46Z [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation relationship: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation creation_date: 2009-12-09T06:54:44Z [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0003379 ! part of establishment of cell polarity involved in gastrulation cell migration creation_date: 2009-12-09T07:10:57Z [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0007369 ! part of gastrulation creation_date: 2009-12-09T07:18:53Z [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell relationship: BFO:0000050 GO:0002064 ! part of epithelial cell development relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell creation_date: 2009-12-09T07:21:06Z [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle relationship: BFO:0000050 GO:0003404 ! part of optic vesicle morphogenesis relationship: BFO:0000050 GO:0060900 ! part of embryonic camera-type eye formation relationship: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle creation_date: 2009-12-21T01:42:37Z [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle relationship: BFO:0000050 GO:0048596 ! part of embryonic camera-type eye morphogenesis relationship: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle creation_date: 2009-12-21T01:54:34Z [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer creation_date: 2009-12-21T02:15:14Z [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis creation_date: 2009-12-21T03:04:27Z [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation intersection_of: GO:0002062 ! chondrocyte differentiation intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0060351 ! part of cartilage development involved in endochondral bone morphogenesis creation_date: 2009-12-22T08:39:58Z [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0003433 ! part of chondrocyte development involved in endochondral bone morphogenesis creation_date: 2009-12-22T08:42:55Z [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone relationship: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone creation_date: 2009-12-22T08:52:55Z [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development intersection_of: GO:0002063 ! chondrocyte development intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0003413 ! part of chondrocyte differentiation involved in endochondral bone morphogenesis creation_date: 2009-12-22T12:42:44Z [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] is_a: BFO:0000015 ! process disjoint_from: GO:0005575 ! cellular_component disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function alt_id: GO:0000496 def: "Binding to a nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" NARROW [] synonym: "microtubule/chromatin interaction" NARROW [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0000785 ! has primary input chromatin relationship: RO:0004009 GO:0000785 ! has primary input chromatin [Term] id: GO:0003723 name: RNA binding namespace: molecular_function alt_id: GO:0000498 alt_id: GO:0044822 def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" is_a: GO:0003676 ! nucleic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis." [GOC:mah] synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] xref: Reactome:R-HSA-9698929 "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex" xref: Reactome:R-HSA-9838004 "LONP1 degrades mitochondrial inner membrane proteins" xref: Reactome:R-HSA-9838081 "LONP1 degrades mitochondrial matrix proteins" xref: Reactome:R-HSA-9838289 "CLPXP degrades mitochondrial matrix proteins" xref: Reactome:R-HSA-9839059 "AFG3L2:SPG7 degrades SMDT1 (EMRE)" xref: Reactome:R-HSA-9839105 "AFG3L2 degrades mitochondrial matrix proteins" xref: Reactome:R-HSA-9839113 "AFG3L2 degrades mitochondrial inner membrane proteins" xref: Reactome:R-HSA-9839146 "YME1L1 degrades mitochondrial inner membrane proteins" xref: Reactome:R-HSA-9839751 "YME1L1 degrades mitochondrial intermembrane space proteins" is_a: GO:0008233 ! peptidase activity is_a: GO:0140657 ! ATP-dependent activity intersection_of: GO:0008233 ! peptidase activity intersection_of: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the cleavage of ester linkages within nucleic acids." [ISBN:0198547684] comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases. subset: goslim_chembl subset: goslim_drosophila subset: goslim_plant subset: goslim_yeast is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid [Term] id: GO:0004536 name: DNA nuclease activity namespace: molecular_function def: "Catalysis of the cleavage of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] synonym: "caspase-activated deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activity" EXACT [] xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40" xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" is_a: GO:0004518 ! nuclease activity is_a: GO:0140097 ! catalytic activity, acting on DNA relationship: BFO:0000050 GO:0006259 ! part of DNA metabolic process [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1.- xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG" xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP" xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL" is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0004568 name: chitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [GOC:bf, GOC:kah, GOC:pde, PMID:11468293] xref: Reactome:R-HSA-6786421 "CHIA hydrolyses chitin" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004888 name: transmembrane signaling receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor] comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling] synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah] xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0004896 name: cytokine receptor activity namespace: molecular_function def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] synonym: "IL receptor" NARROW [] synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140375 ! immune receptor activity relationship: BFO:0000050 GO:0019221 ! part of cytokine-mediated signaling pathway relationship: BFO:0000051 GO:0019955 ! has part cytokine binding [Term] id: GO:0004925 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 PR:000013246 ! has primary input prolactin relationship: BFO:0000050 GO:0038161 ! part of prolactin signaling pathway relationship: RO:0004009 PR:000013246 ! has primary input prolactin [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13" xref: Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq" xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" xref: Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)" xref: Wikipedia:GPCR is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: BFO:0000050 GO:0007186 ! part of G protein-coupled receptor signaling pathway [Term] id: GO:0004977 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004978 name: corticotropin receptor activity namespace: molecular_function def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] synonym: "adrenocorticotropin receptor activity" EXACT [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:3892 ! has primary input relationship: BFO:0000051 GO:0042562 ! has part hormone binding relationship: RO:0004009 CHEBI:3892 ! has primary input [Term] id: GO:0004993 name: G protein-coupled serotonin receptor activity namespace: molecular_function def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein coupled serotonin receptor activity" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity intersection_of: GO:0008227 ! G protein-coupled amine receptor activity intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: BFO:0000050 GO:0098664 ! part of G protein-coupled serotonin receptor signaling pathway relationship: BFO:0000051 GO:0051378 ! has part serotonin binding relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0005000 name: vasopressin receptor activity namespace: molecular_function def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:9937 ! has primary input relationship: RO:0004009 CHEBI:9937 ! has primary input [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005126 name: cytokine receptor binding namespace: molecular_function def: "Binding to a cytokine receptor." [GOC:mah, GOC:vw] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005172 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Binding to a vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] synonym: "VEGF receptor binding" EXACT [] synonym: "VEGFR binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001971 ! has primary input vascular endothelial growth factor receptor relationship: RO:0004009 PR:000001971 ! has primary input vascular endothelial growth factor receptor [Term] id: GO:0005173 name: stem cell factor receptor binding namespace: molecular_function def: "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000002065 ! has primary input mast/stem cell growth factor receptor relationship: RO:0004009 PR:000002065 ! has primary input mast/stem cell growth factor receptor [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "carrier" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: BFO:0000050 GO:0015837 ! part of amine transport relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles" is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:1901375 ! acetate ester transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0005313 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glutamate transmembrane transporter activity" BROAD [] synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle" xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+" xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+" is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: BFO:0000050 GO:0015813 ! part of L-glutamate transmembrane transport relationship: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: BFO:0000050 GO:0006869 ! part of lipid transport relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0005326 name: neurotransmitter transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] synonym: "neurotransmitter transporter activity" RELATED [] xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline" xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" is_a: GO:0022857 ! transmembrane transporter activity relationship: BFO:0000050 GO:0006836 ! part of neurotransmitter transport relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: BFO:0000050 GO:1903825 ! part of organic acid transmembrane transport relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] subset: goslim_pir subset: goslim_plant synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0008289 ! lipid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35341 ! has primary input steroid relationship: RO:0004009 CHEBI:35341 ! has primary input steroid [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Binding to a protein." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: Reactome:R-HSA-9866132 "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH" is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0005518 name: collagen binding namespace: molecular_function def: "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0097367 ! carbohydrate derivative binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:18085 ! has primary input relationship: RO:0004009 CHEBI:18085 ! has primary input [Term] id: GO:0005540 name: hyaluronic acid binding namespace: molecular_function def: "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl] synonym: "hyaluronan binding" EXACT [] is_a: GO:0005539 ! glycosaminoglycan binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16336 ! has primary input relationship: RO:0004009 CHEBI:16336 ! has primary input [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao1337158144 is_a: BFO:0000040 ! material entity disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000050 GO:0005615 ! part of extracellular space [Term] id: GO:0005581 name: collagen trimer namespace: cellular_component def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0005583 name: fibrillar collagen trimer namespace: cellular_component def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0098643 ! part of fibrillar collagen disjoint_from: GO:0030936 ! transmembrane collagen trimer relationship: BFO:0000050 GO:0098643 ! part of fibrillar collagen [Term] id: GO:0005585 name: collagen type II trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer relationship: BFO:0000050 GO:0005604 ! part of basement membrane [Term] id: GO:0005604 name: basement membrane namespace: cellular_component def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [PMID:22505934, PMID:33605520, PMID:39223427] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. synonym: "basal lamina" RELATED [] synonym: "basement lamina" RELATED [] synonym: "lamina densa" RELATED [] xref: Wikipedia:Basement_membrane is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0005622 name: intracellular anatomical structure namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "intracellular" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm disjoint_from: GO:0005829 ! cytosol relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "nucleus outer envelope" EXACT [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005634 ! bounding layer of nucleus relationship: BFO:0000050 GO:0042175 ! part of nuclear outer membrane-endoplasmic reticulum membrane network relationship: RO:0002007 GO:0005634 ! bounding layer of nucleus [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular membraneless organelle [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular membraneless organelle relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0005739 ! part of mitochondrion [Term] id: GO:0005741 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] synonym: "mitochondrion outer membrane" EXACT [] synonym: "outer mitochondrial membrane" EXACT [] synonym: "outer mitochondrion membrane" EXACT [] xref: NIF_Subcellular:sao1289741256 xref: Wikipedia:Outer_mitochondrial_membrane is_a: GO:0031966 ! mitochondrial membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005739 ! bounding layer of mitochondrion relationship: RO:0002007 GO:0005739 ! bounding layer of mitochondrion [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0070013 ! intracellular organelle lumen relationship: BFO:0000050 GO:0005739 ! part of mitochondrion [Term] id: GO:0005761 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] synonym: "55S ribosome, mitochondrial" NARROW [] is_a: GO:0000313 ! organellar ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0005759 ! part of mitochondrial matrix relationship: BFO:0000050 GO:0005759 ! part of mitochondrial matrix [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] synonym: "lysosome membrane" EXACT [] is_a: GO:0098852 ! lytic vacuole membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005764 ! bounding layer of lysosome relationship: RO:0002007 GO:0005764 ! bounding layer of lysosome [Term] id: GO:0005766 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005773 ! bounding layer of vacuole relationship: RO:0002007 GO:0005773 ! bounding layer of vacuole [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0005773 ! part of vacuole relationship: BFO:0000050 GO:0005773 ! part of vacuole [Term] id: GO:0005776 name: autophagosome namespace: cellular_component def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] xref: NIF_Subcellular:sao8663416959 is_a: GO:0005773 ! vacuole [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732, PMID:9695800] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0012505 ! part of endomembrane system relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043232 ! intracellular membraneless organelle [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005840 name: ribosome namespace: cellular_component def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular membraneless organelle relationship: BFO:0000051 CHEBI:33697 ! has part ribonucleic acid relationship: BFO:0000051 PR:000000001 ! has part protein relationship: RO:0002216 GO:0006412 ! capable of part of translation [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular membraneless organelle [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] subset: goslim_metagenomics synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005930 ! part of axoneme relationship: BFO:0000050 GO:0005930 ! part of axoneme [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0005634 ! part of nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005887 alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "integral component of plasma membrane" NARROW [] synonym: "integral to plasma membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673] xref: NIF_Subcellular:sao671419673 xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: BFO:0000050 CL:0000066 ! part of epithelial cell relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle [Term] id: GO:0005903 name: brush border namespace: cellular_component def: "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Brush_border is_a: GO:0098862 ! cluster of actin-based cell projections relationship: BFO:0000050 CL:0000066 ! part of epithelial cell relationship: BFO:0000050 GO:0045177 ! part of apical part of cell relationship: BFO:0000051 GO:0005902 ! has part microvillus [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] synonym: "cell-cell contact region" BROAD [] synonym: "cell-cell contact zone" BROAD [] synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368] xref: NIF_Subcellular:sao1922892319 is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005923 name: bicellular tight junction namespace: cellular_component def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] synonym: "zonula occludens" EXACT [] xref: NIF_Subcellular:sao1939999134 xref: Wikipedia:Tight_junction is_a: GO:0070160 ! tight junction relationship: BFO:0000050 GO:0043296 ! part of apical junction complex [Term] id: GO:0005929 name: cilium namespace: cellular_component def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: BFO:0000051 GO:0030990 ! has part intraciliary transport particle relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0005930 name: axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. subset: goslim_pir synonym: "ciliary axoneme" EXACT [] synonym: "cilium axoneme" EXACT [] synonym: "flagellar axoneme" EXACT [] synonym: "flagellum axoneme" EXACT [] xref: Wikipedia:Axoneme is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton relationship: BFO:0000050 GO:0097014 ! part of ciliary plasm relationship: BFO:0000051 GO:0005874 ! has part microtubule [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "ectoplasm" NARROW [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0071944 ! part of cell periphery relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:R-HSA-71387 "Metabolism of carbohydrates" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16646 ! has primary input or output carbohydrate relationship: RO:0004007 CHEBI:16646 ! has primary input or output carbohydrate creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] subset: goslim_pir synonym: "glycan metabolic process" NARROW [] synonym: "glycan metabolism" NARROW [] synonym: "multicellular organismal polysaccharide metabolic process" NARROW [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18154 ! has primary input or output polysaccharide relationship: RO:0004007 CHEBI:18154 ! has primary input or output polysaccharide [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan relationship: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:22506 ! has primary output aminoglycan relationship: RO:0004008 CHEBI:22506 ! has primary output aminoglycan [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18085 ! has primary output relationship: RO:0004008 CHEBI:18085 ! has primary output [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:22506 ! has primary input aminoglycan relationship: RO:0004009 CHEBI:22506 ! has primary input aminoglycan [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] xref: Reactome:R-HSA-2024101 "CS/DS degradation" is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18085 ! has primary input relationship: RO:0004009 CHEBI:18085 ! has primary input [Term] id: GO:0006033 name: chitin localization namespace: biological_process def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chitin localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chitin localization" EXACT [] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:64709 ! has primary input or output organic acid relationship: RO:0004007 CHEBI:64709 ! has primary input or output organic acid [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process relationship: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:61120 ! has primary input or output nucleobase-containing molecular entity relationship: RO:0004007 CHEBI:61120 ! has primary input or output nucleobase-containing molecular entity [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16991 ! has primary input or output relationship: RO:0004007 CHEBI:16991 ! has primary input or output [Term] id: GO:0006308 name: DNA catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] synonym: "DNA breakdown" EXACT [] synonym: "DNA catabolism" EXACT [] synonym: "DNA degradation" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0141188 ! nucleic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: BFO:0000051 GO:0004536 ! has part DNA nuclease activity relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0006309 name: apoptotic DNA fragmentation namespace: biological_process def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis] synonym: "DNA catabolic process during apoptosis" EXACT [] synonym: "DNA catabolism during apoptosis" EXACT [] synonym: "DNA fragmentation" BROAD [] synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb] synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] xref: Reactome:R-HSA-140342 "Apoptosis induced DNA fragmentation" is_a: GO:0006308 ! DNA catabolic process intersection_of: GO:0006308 ! DNA catabolic process intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes [Term] id: GO:0006325 name: chromatin organization namespace: biological_process def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "chromatin assembly" NARROW [] synonym: "chromatin assembly or disassembly" RELATED [] synonym: "chromatin assembly/disassembly" RELATED [] synonym: "chromatin maintenance" BROAD [] synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "DNA replication-independent chromatin assembly" NARROW [] synonym: "DNA replication-independent chromatin organization" NARROW [] synonym: "DNA replication-independent nucleosome organisation" NARROW [] synonym: "DNA replication-independent nuclesome assembly" NARROW [] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] synonym: "transcription-coupled nucleosome assembly" NARROW [] xref: Reactome:R-HSA-4839726 "Chromatin organization" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin relationship: RO:0002592 GO:0000785 ! results in organization of chromatin [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_yeast synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0141188 ! nucleic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006404 name: RNA import into nucleus namespace: biological_process def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] synonym: "RNA import into cell nucleus" EXACT [] synonym: "RNA transport from cytoplasm to nucleus" EXACT [] synonym: "RNA-nucleus import" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051170 ! import into nucleus intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:R-HSA-72766 "Translation" xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: BFO:0000050 GO:0010467 ! part of gene expression intersection_of: RO:0004008 CHEBI:36080 ! has primary output protein relationship: BFO:0000050 GO:0010467 ! part of gene expression relationship: BFO:0000051 GO:0006414 ! has part translational elongation relationship: RO:0002224 GO:0006413 ! starts with translational initiation relationship: RO:0002230 GO:0006415 ! ends with translational termination relationship: RO:0004008 CHEBI:36080 ! has primary output protein [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] xref: Reactome:R-HSA-72613 "Eukaryotic Translation Initiation" is_a: GO:0008152 ! metabolic process relationship: BFO:0000050 GO:0006412 ! part of translation relationship: RO:0002224 GO:0001677 ! starts with formation of translation initiation ternary complex [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: Reactome:R-HSA-156842 "Eukaryotic Translation Elongation" is_a: GO:0009059 ! macromolecule biosynthetic process relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] xref: Reactome:R-HSA-72764 "Eukaryotic Translation Termination" is_a: GO:0032984 ! protein-containing complex disassembly relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] subset: goslim_yeast synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: RO:0002211 GO:0006412 ! regulates translation [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation relationship: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006414 ! regulates translational elongation relationship: RO:0002211 GO:0006414 ! regulates translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006415 ! regulates translational termination relationship: RO:0002211 GO:0006415 ! regulates translational termination [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: gocheck_obsoletion_candidate subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0016310 ! phosphorylation is_a: GO:0036211 ! protein modification process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] subset: goslim_pir synonym: "peptide metabolism" EXACT [] xref: Reactome:R-HSA-2980736 "Peptide hormone metabolism" is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:60466 ! has primary input or output peptide zwitterion relationship: RO:0004007 CHEBI:60466 ! has primary input or output peptide zwitterion [Term] id: GO:0006520 name: amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "amino acid and derivative metabolism" RELATED [] synonym: "cellular amino acid and derivative metabolic process" RELATED [] synonym: "cellular amino acid metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35238 ! has primary input or output amino-acid zwitterion relationship: RO:0004007 CHEBI:35238 ! has primary input or output amino-acid zwitterion [Term] id: GO:0006521 name: regulation of amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] synonym: "regulation of amino acid metabolism" EXACT [] xref: Reactome:R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)" is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006520 ! regulates amino acid metabolic process relationship: RO:0002211 GO:0006520 ! regulates amino acid metabolic process [Term] id: GO:0006536 name: glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate metabolism" EXACT [] synonym: "glutamic acid metabolic process" EXACT [] synonym: "glutamic acid metabolism" EXACT [] xref: Wikipedia:Glutamic_acid is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:14321 ! has primary input or output relationship: RO:0004007 CHEBI:14321 ! has primary input or output [Term] id: GO:0006537 name: glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate anabolism" EXACT [] synonym: "glutamate biosynthesis" EXACT [] synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate formation" EXACT [] synonym: "glutamate synthesis" EXACT [] synonym: "glutamic acid biosynthesis" EXACT [] synonym: "glutamic acid biosynthetic process" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:14321 ! has primary output relationship: RO:0004008 CHEBI:14321 ! has primary output [Term] id: GO:0006538 name: L-glutamate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate breakdown" EXACT [] synonym: "glutamate catabolism" EXACT [] synonym: "glutamate deamidation" RELATED [] synonym: "glutamate degradation" EXACT [] synonym: "glutamic acid catabolic process" EXACT [] synonym: "glutamic acid catabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0006544 name: glycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:57305 ! has primary input or output relationship: RO:0004007 CHEBI:57305 ! has primary input or output [Term] id: GO:0006545 name: glycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine anabolism" EXACT [] synonym: "glycine biosynthesis" EXACT [] synonym: "glycine formation" EXACT [] synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:57305 ! has primary output relationship: RO:0004008 CHEBI:57305 ! has primary output [Term] id: GO:0006546 name: glycine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine breakdown" EXACT [] synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] xref: Reactome:R-HSA-6783984 "Glycine degradation" is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0170040 ! proteinogenic amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0006553 name: lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine metabolism" EXACT [] xref: Wikipedia:Lysine is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006576 name: biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine metabolism" EXACT [] synonym: "cellular biogenic amine metabolic process" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine metabolism" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33567 ! has primary input or output relationship: RO:0004007 CHEBI:33567 ! has primary input or output [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0051170 ! import into nucleus is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051168 ! nuclear export intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Reactome:R-HSA-556833 "Metabolism of lipids" xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output lipid relationship: RO:0004007 CHEBI:18059 ! has primary input or output lipid [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output lipid relationship: BFO:0000066 GO:0016020 ! occurs in membrane [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35341 ! has primary output steroid relationship: RO:0004008 CHEBI:35341 ! has primary output steroid [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35341 ! has primary input steroid relationship: RO:0004009 CHEBI:35341 ! has primary input steroid [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0006629 ! lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26082 ! has primary input or output phosphorus molecular entity relationship: RO:0004007 CHEBI:26082 ! has primary input or output phosphorus molecular entity [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26020 ! has primary input or output phosphate relationship: RO:0004007 CHEBI:26020 ! has primary input or output phosphate [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "single-organism transport" RELATED [] xref: Reactome:R-HSA-382551 "Transport of small molecules" is_a: GO:0051234 ! establishment of localization created_by: jl creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006811 name: monoatomic ion transport namespace: biological_process def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "ion transport" BROAD [] xref: Reactome:R-HSA-425393 "Transport of inorganic cations/anions and amino acids/oligopeptides" is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion relationship: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] xref: Reactome:R-HSA-181429 "Serotonin Neurotransmitter Release Cycle" xref: Reactome:R-HSA-181430 "Norepinephrine Neurotransmitter Release Cycle" xref: Reactome:R-HSA-210500 "Glutamate Neurotransmitter Release Cycle" xref: Reactome:R-HSA-212676 "Dopamine Neurotransmitter Release Cycle" xref: Reactome:R-HSA-264642 "Acetylcholine Neurotransmitter Release Cycle" is_a: GO:0006810 ! transport relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] subset: goslim_drosophila is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002344 GO:0005739 ! results in transport to from or in mitochondrion relationship: RO:0002344 GO:0005739 ! results in transport to from or in mitochondrion [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport intersection_of: GO:0006865 ! amino acid transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast xref: Reactome:R-HSA-352230 "Amino acid transport across the plasma membrane" is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast xref: Reactome:R-HSA-1369062 "ABC transporters in lipid homeostasis" is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: BFO:0000050 GO:0010876 ! part of lipid localization relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: goslim_generic subset: goslim_prokaryote synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0004009 PR:000000001 ! has primary input protein intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000050 GO:0008104 ! part of intracellular protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] subset: goslim_yeast synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle relationship: BFO:0000051 GO:0099500 ! has part vesicle fusion to plasma membrane relationship: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] xref: Reactome:R-HSA-199992 "trans-Golgi Network Vesicle Budding" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0005773 ! has target end location vacuole [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 alt_id: GO:0098701 def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] subset: goslim_yeast synonym: "endocytic import into cell" EXACT [] synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" NARROW [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell relationship: BFO:0000051 GO:0006900 ! has part vesicle budding from membrane relationship: BFO:0000051 GO:0010324 ! has part membrane invagination relationship: RO:0002339 GO:0031410 ! has target end location cytoplasmic vesicle [Term] id: GO:0006900 name: vesicle budding from membrane namespace: biological_process alt_id: GO:0006902 alt_id: GO:1902591 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "single organism membrane budding" RELATED [GOC:TermGenie] synonym: "single-organism membrane budding" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport created_by: jl creation_date: 2013-12-19T15:26:17Z [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localization [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane [Term] id: GO:0006909 name: phagocytosis namespace: biological_process def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] xref: Reactome:R-HSA-9664417 "Leishmania phagocytosis" xref: Wikipedia:Phagocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0051169 ! nuclear transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope intersection_of: RO:0002344 GO:0005829 ! results in transport to from or in cytosol intersection_of: RO:0002344 GO:0031981 ! results in transport to from or in nuclear lumen relationship: RO:0002342 GO:0005635 ! results in transport across nuclear envelope relationship: RO:0002344 GO:0005829 ! results in transport to from or in cytosol relationship: RO:0002344 GO:0031981 ! results in transport to from or in nuclear lumen [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Reactome:R-HSA-9612973 "Autophagy" xref: Wikipedia:Autophagy_(cellular) is_a: GO:0009056 ! catabolic process is_a: GO:0061919 ! process utilizing autophagic mechanism relationship: BFO:0000051 GO:0055085 ! has part transmembrane transport [Term] id: GO:0006915 name: apoptotic process namespace: biological_process def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Reactome:R-HSA-109581 "Apoptosis" xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death relationship: RO:0002224 GO:0097190 ! starts with apoptotic signaling pathway relationship: RO:0002230 GO:0097194 ! ends with execution phase of apoptosis [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] synonym: "cellular component disassembly involved in apoptosis" NARROW [] synonym: "cellular component disassembly involved in apoptotic process" BROAD [] synonym: "disassembly of cell structures" BROAD [] is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis relationship: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis [Term] id: GO:0006925 name: inflammatory cell apoptotic process namespace: biological_process def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell apoptosis" NARROW [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] synonym: "killing of inflammatory cells" EXACT [] synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] synonym: "programmed cell death, inflammatory cells" EXACT [] xref: Reactome:R-HSA-168277 "Influenza Virus Induced Apoptosis" is_a: GO:0006915 ! apoptotic process [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] synonym: "taxis in response to chemical stimulus" EXACT [] xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: BFO:0000050 GO:0042221 ! part of response to chemical [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] subset: goslim_pir xref: Reactome:R-HSA-445355 "Smooth Muscle Contraction" xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006936 ! regulates muscle contraction relationship: RO:0002211 GO:0006936 ! regulates muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "visceral muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006939 ! regulates smooth muscle contraction relationship: RO:0002211 GO:0006939 ! regulates smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "sarcomeric muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006941 ! regulates striated muscle contraction relationship: RO:0002211 GO:0006941 ! regulates striated muscle contraction [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 CL:0000228 ! results in formation of multinucleate cell relationship: RO:0002297 CL:0000228 ! results in formation of multinucleate cell [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] subset: goslim_generic synonym: "inflammation" BROAD [] xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] subset: goslim_drosophila is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: goslim_yeast is_a: GO:0006950 ! response to stress [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] xref: Reactome:R-HSA-1852241 "Organelle biogenesis and maintenance" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043226 ! results in organization of organelle relationship: RO:0002592 GO:0043226 ! results in organization of organelle created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [] synonym: "nuclear organization" EXACT [] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005634 ! results in organization of nucleus relationship: RO:0002592 GO:0005634 ! results in organization of nucleus [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005635 ! results in organization of nuclear envelope relationship: BFO:0000050 GO:0006997 ! part of nucleus organization relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0005635 ! results in organization of nuclear envelope [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005730 ! results in organization of nucleolus relationship: RO:0002592 GO:0005730 ! results in organization of nucleolus [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrial biogenesis" EXACT [] synonym: "mitochondrial organization" EXACT [] synonym: "mitochondrion biogenesis" EXACT [] synonym: "mitochondrion morphogenesis" RELATED [] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [] xref: Reactome:R-HSA-1592230 "Mitochondrial biogenesis" is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005739 ! results in organization of mitochondrion relationship: RO:0002592 GO:0005739 ! results in organization of mitochondrion [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0007008 name: outer mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. synonym: "outer mitochondrial membrane organisation" EXACT [] synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005741 ! results in organization of mitochondrial outer membrane relationship: RO:0002592 GO:0005741 ! results in organization of mitochondrial outer membrane [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl synonym: "plasma membrane organisation" EXACT [] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005886 ! results in organization of plasma membrane relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0005886 ! results in organization of plasma membrane [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005856 ! results in organization of cytoskeleton relationship: RO:0002592 GO:0005856 ! results in organization of cytoskeleton [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005884 ! results in organization of actin filament relationship: BFO:0000050 GO:0030036 ! part of actin cytoskeleton organization relationship: RO:0002592 GO:0005884 ! results in organization of actin filament [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] subset: goslim_drosophila subset: goslim_generic xref: Reactome:R-HSA-983189 "Kinesins" is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] synonym: "microtubule shortening" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005874 ! results in disassembly of microtubule relationship: RO:0002590 GO:0005874 ! results in disassembly of microtubule [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: BFO:0000050 GO:0046785 ! part of microtubule polymerization [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization relationship: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization relationship: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "cytoplasm organisation" EXACT [] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005737 ! results in organization of cytoplasm relationship: RO:0002592 GO:0005737 ! results in organization of cytoplasm [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi apparatus organization" EXACT [] synonym: "Golgi organisation" EXACT [] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_drosophila subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005773 ! results in organization of vacuole relationship: RO:0002592 GO:0005773 ! results in organization of vacuole [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole [Term] id: GO:0007040 name: lysosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] subset: goslim_generic synonym: "lysosome organisation" EXACT [] synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0080171 ! lytic vacuole organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005764 ! results in organization of lysosome relationship: RO:0002592 GO:0005764 ! results in organization of lysosome [Term] id: GO:0007041 name: lysosomal transport namespace: biological_process def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002344 GO:0005764 ! results in transport to from or in lysosome relationship: RO:0002344 GO:0005764 ! results in transport to from or in lysosome [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization intersection_of: GO:0034329 ! cell junction assembly intersection_of: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction relationship: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell-division cycle" EXACT [] xref: Reactome:R-HSA-1640170 "Cell Cycle" xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] xref: Reactome:R-HSA-2299718 "Condensation of Prophase Chromosomes" xref: Reactome:R-HSA-2514853 "Condensation of Prometaphase Chromosomes" is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030261 ! chromosome condensation intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle relationship: BFO:0000050 GO:0000070 ! part of mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear membrane disassembly namespace: biological_process def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252] synonym: "local NEB" BROAD [] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" RELATED [] synonym: "mitotic nuclear envelope degradation" RELATED [] synonym: "mitotic nuclear envelope disassembly" RELATED [] synonym: "NEB" BROAD [] synonym: "nuclear envelope breakdown" BROAD [] xref: Reactome:R-HSA-2980766 "Nuclear Envelope Breakdown" is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140014 ! regulates mitotic nuclear division relationship: RO:0002211 GO:0140014 ! regulates mitotic nuclear division [Term] id: GO:0007097 name: nuclear migration namespace: biological_process alt_id: GO:0040023 def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] synonym: "establishment of nucleus localization" RELATED [] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear movement" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus migration" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] synonym: "meiosis I nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0061982 ! meiosis I cell cycle process is_a: GO:0140013 ! meiotic nuclear division relationship: RO:0002093 GO:0007134 ! ends during meiotic telophase I [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] synonym: "meiosis II nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0061983 ! meiosis II cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0007143 name: female meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. synonym: "female meiosis" BROAD [] synonym: "female meiotic division" BROAD [] is_a: GO:0140013 ! meiotic nuclear division intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0007292 ! part of female gamete generation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle relationship: BFO:0000050 GO:0007292 ! part of female gamete generation [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007143 ! female meiotic nuclear division intersection_of: GO:0007135 ! meiosis II intersection_of: BFO:0000050 GO:0007292 ! part of female gamete generation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007159 name: leukocyte cell-cell adhesion namespace: biological_process def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] synonym: "leukocyte adhesion" EXACT [] synonym: "leukocyte cell adhesion" EXACT [] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: RO:0000057 CL:0000738 ! has participant leukocyte relationship: RO:0000057 CL:0000738 ! has participant leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007155 ! negatively regulates cell adhesion relationship: RO:0002212 GO:0007155 ! negatively regulates cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023014 alt_id: GO:0023015 alt_id: GO:0023016 alt_id: GO:0023033 alt_id: GO:0023045 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [] xref: Reactome:R-HSA-212718 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: BFO:0000050 GO:0007154 ! part of cell communication relationship: BFO:0000050 GO:0023052 ! part of signaling relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus [Term] id: GO:0007166 name: cell surface receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] subset: goslim_drosophila synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] xref: Reactome:R-HSA-73887 "Death Receptor Signaling" is_a: GO:0007165 ! signal transduction [Term] id: GO:0007186 name: G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] subset: goslim_drosophila synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf] synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf] synonym: "G-protein coupled receptor signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR signaling pathway" EXACT [] synonym: "GPCR signalling pathway" EXACT [] xref: Reactome:R-HSA-373076 "Class A/1 (Rhodopsin-like receptors)" xref: Reactome:R-HSA-388396 "GPCR downstream signalling" is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0004930 ! starts with G protein-coupled receptor activity relationship: RO:0002224 GO:0004930 ! starts with G protein-coupled receptor activity [Term] id: GO:0007213 name: G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT [] synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0095500 ! acetylcholine receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0016907 ! starts with G protein-coupled acetylcholine receptor activity relationship: RO:0002224 GO:0016907 ! starts with G protein-coupled acetylcholine receptor activity [Term] id: GO:0007214 name: gamma-aminobutyric acid signaling pathway namespace: biological_process def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell." [GOC:mah] synonym: "4-aminobutanoate signaling pathway" EXACT [] synonym: "4-aminobutanoate signalling pathway" EXACT [] synonym: "4-aminobutyrate signaling pathway" EXACT [] synonym: "4-aminobutyrate signalling pathway" EXACT [] synonym: "GABA signaling pathway" EXACT [] synonym: "GABA signalling pathway" EXACT [] synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002224 GO:0016917 ! starts with GABA receptor activity relationship: RO:0002224 GO:0016917 ! starts with GABA receptor activity [Term] id: GO:0007215 name: glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "glutamate signaling pathway" EXACT [GOC:bf] synonym: "glutamate signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0008066 ! starts with glutamate receptor activity relationship: RO:0002224 GO:0008066 ! starts with glutamate receptor activity [Term] id: GO:0007216 name: G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007215 ! glutamate receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0098988 ! starts with G protein-coupled glutamate receptor activity relationship: RO:0002224 GO:0098988 ! starts with G protein-coupled glutamate receptor activity [Term] id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: chemical synaptic transmission namespace: biological_process def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] subset: goslim_synapse synonym: "neurotransmission" RELATED [GOC:dph] synonym: "signal transmission across a synapse" BROAD [] synonym: "synaptic transmission" BROAD [] xref: Reactome:R-HSA-112316 "Neuronal System" xref: Reactome:R-HSA-442720 "CREB1 phosphorylation through the activation of Adenylate Cyclase" xref: Reactome:R-HSA-442729 "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" xref: Reactome:R-HSA-442742 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling" xref: Reactome:R-HSA-451307 "Activation of Na-permeable kainate receptors" xref: Reactome:R-HSA-451308 "Activation of Ca-permeable Kainate Receptor" xref: Reactome:R-HSA-9619229 "Activation of RAC1 downstream of NMDARs" xref: Reactome:R-HSA-9619483 "Activation of AMPK downstream of NMDARs" xref: Reactome:R-HSA-9620244 "Long-term potentiation" xref: Wikipedia:Neurotransmission is_a: GO:0098916 ! anterograde trans-synaptic signaling relationship: RO:0000057 GO:0045202 ! has participant synapse [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph] comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. subset: goslim_synapse synonym: "neurotransmitter release" EXACT [] synonym: "neurotransmitter secretory pathway" EXACT [] xref: Reactome:R-HSA-112310 "Neurotransmitter release cycle" is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099643 ! signal release from synapse relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: RO:0002338 GO:0098793 ! has target start location presynapse relationship: RO:0002339 GO:0043083 ! has target end location synaptic cleft [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic] synonym: "cholinergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission relationship: RO:0000057 CHEBI:15355 ! has participant [Term] id: GO:0007272 name: ensheathment of neurons namespace: biological_process def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] synonym: "ionic insulation of neurons by glial cells" RELATED [] is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0000057 CL:0000125 ! has participant glial cell relationship: RO:0000057 CL:0000540 ! has participant neuron [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism relationship: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism [Term] id: GO:0007276 name: gamete generation namespace: biological_process def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "gametogenesis" NARROW [] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] xref: Reactome:R-HSA-9827857 "Specification of primordial germ cells" is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000586 ! results in development of germ cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0002296 CL:0000586 ! results in development of germ cell [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: GO:0007308 name: oocyte construction namespace: biological_process def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002297 CL:0000023 ! results in formation of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002297 CL:0000023 ! results in formation of oocyte [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] xref: Reactome:R-HSA-1187000 "Fertilization" is_a: GO:0009566 ! fertilization relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000025 ! has primary input egg cell relationship: BFO:0000050 GO:0007338 ! part of single fertilization relationship: RO:0004009 CL:0000025 ! has primary input egg cell [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-2465910 "MASTL Facilitates Mitotic Progression" xref: Reactome:R-HSA-68911 "G2 Phase" is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000278 ! regulates mitotic cell cycle relationship: RO:0002211 GO:0000278 ! regulates mitotic cell cycle [Term] id: GO:0007350 name: blastoderm segmentation namespace: biological_process def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0035282 ! segmentation [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] subset: goslim_drosophila xref: Reactome:R-HSA-9758941 "Gastrulation" xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis relationship: BFO:0000051 GO:0001705 ! has part ectoderm formation relationship: BFO:0000051 GO:0001706 ! has part endoderm formation relationship: BFO:0000051 GO:0001707 ! has part mesoderm formation [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] subset: goslim_drosophila synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000924 ! results in development of ectoderm relationship: RO:0002296 UBERON:0000924 ! results in development of ectoderm [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] subset: goslim_drosophila synonym: "pan-neural process" RELATED [] xref: Reactome:R-HSA-9675108 "Nervous system development" is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001016 ! results in development of nervous system relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0001016 ! results in development of nervous system [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata) [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation relationship: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation [Term] id: GO:0007407 name: neuroblast activation namespace: biological_process def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0007409 name: axonogenesis namespace: biological_process def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). synonym: "axon growth" NARROW [] synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308] is_a: GO:0048812 ! neuron projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0030424 ! results in morphogenesis of axon relationship: BFO:0000050 GO:0048667 ! part of cell morphogenesis involved in neuron differentiation relationship: BFO:0000050 GO:0061564 ! part of axon development relationship: RO:0002298 GO:0030424 ! results in morphogenesis of axon [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah] subset: goslim_synapse synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0034329 ! cell junction assembly is_a: GO:0050808 ! synapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0045202 ! results in assembly of synapse relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002588 GO:0045202 ! results in assembly of synapse [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001017 ! results in development of central nervous system relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002296 UBERON:0001017 ! results in development of central nervous system [Term] id: GO:0007418 name: ventral midline development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0009571 ! results in development of ventral midline relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002296 UBERON:0009571 ! results in development of ventral midline [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000955 ! results in development of brain relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: BFO:0000050 GO:0060322 ! part of head development relationship: RO:0002296 UBERON:0000955 ! results in development of brain [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] subset: goslim_drosophila synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000020 ! results in development of sense organ relationship: RO:0002296 UBERON:0000020 ! results in development of sense organ [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002297 UBERON:0004906 ! results in formation of ectodermal part of digestive tract relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002297 UBERON:0004906 ! results in formation of ectodermal part of digestive tract [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut relationship: BFO:0000050 GO:0048546 ! part of digestive tract morphogenesis relationship: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000925 ! results in development of endoderm relationship: RO:0002296 UBERON:0000925 ! results in development of endoderm [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] subset: goslim_drosophila is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000926 ! results in development of mesoderm relationship: RO:0002296 UBERON:0000926 ! results in development of mesoderm [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme relationship: BFO:0000050 GO:0008406 ! part of gonad development relationship: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme [Term] id: GO:0007507 name: heart development namespace: biological_process def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ relationship: BFO:0000050 GO:0072359 ! part of circulatory system development relationship: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] is_a: GO:0048513 ! animal organ development is_a: GO:0061061 ! muscle structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001630 ! results in development of muscle organ relationship: RO:0002296 UBERON:0001630 ! results in development of muscle organ [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] synonym: "myogenesis" RELATED [] is_a: GO:0014706 ! striated muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue relationship: BFO:0000050 GO:0060538 ! part of skeletal muscle organ development relationship: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] synonym: "neuromuscular junction organization" EXACT [] synonym: "neuromuscular junction stability" RELATED [GOC:pr] synonym: "NMJ stability" RELATED [GOC:pr] is_a: GO:0050808 ! synapse organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction relationship: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] subset: goslim_chembl synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia [Term] id: GO:0007566 name: embryo implantation namespace: biological_process def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, PMID:10882512] synonym: "blastocyst implantation" EXACT [] is_a: GO:0022414 ! reproductive process relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: BFO:0000050 GO:0007565 ! part of female pregnancy [Term] id: GO:0007585 name: respiratory gaseous exchange by respiratory system namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: Reactome:R-HSA-8935690 "Digestion" xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] subset: goslim_drosophila xref: Reactome:R-HSA-9709957 "Sensory Perception" xref: Wikipedia:Perception is_a: GO:0050877 ! nervous system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Reactome:R-HSA-9659379 "Sensory processing of sound" xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007610 name: behavior namespace: biological_process def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0032501 ! multicellular organismal process disjoint_from: GO:0032502 ! developmental process relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002608 UBERON:0001016 ! process has causal agent nervous system creation_date: 2012-09-20T14:06:08Z [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0008015 name: blood circulation namespace: biological_process def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060047 ! regulates heart contraction relationship: RO:0002211 GO:0060047 ! regulates heart contraction [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs" is_a: GO:0015631 ! tubulin binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005874 ! has primary input microtubule relationship: RO:0004009 GO:0005874 ! has primary input microtubule [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:R-HSA-429749 "SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25384 ! has primary input monocarboxylic acid relationship: BFO:0000050 GO:0015718 ! part of monocarboxylic acid transport relationship: RO:0004009 CHEBI:25384 ! has primary input monocarboxylic acid [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774] synonym: "mitochondrial membrane fusion" RELATED [] synonym: "mitochondrion fusion" EXACT [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005739 ! results in fusion of mitochondrion relationship: RO:0012008 GO:0005739 ! results in fusion of mitochondrion creation_date: 2015-01-21T06:58:18Z [Term] id: GO:0008061 name: chitin binding namespace: molecular_function def: "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0008066 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: BFO:0000051 GO:0016595 ! has part glutamate binding relationship: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0008078 name: mesodermal cell migration namespace: biological_process def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] synonym: "mesoderm cell migration" EXACT [] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000222 ! results in movement of mesodermal cell relationship: RO:0002565 CL:0000222 ! results in movement of mesodermal cell [Term] id: GO:0008088 name: axo-dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" NARROW [] synonym: "axonal transport" NARROW [] synonym: "axoplasmic transport" NARROW [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! transport along microtubule intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0043005 ! occurs in neuron projection relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0008089 name: anterograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "anterograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm relationship: RO:0002339 GO:0098793 ! has target end location presynapse [Term] id: GO:0008090 name: retrograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm relationship: RO:0002338 GO:0098793 ! has target start location presynapse [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_prokaryote subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0008104 name: intracellular protein localization namespace: biological_process alt_id: GO:0008105 alt_id: GO:0016249 alt_id: GO:0034613 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "cellular protein localization" EXACT [] synonym: "channel localizer activity" NARROW [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] synonym: "protein localization" BROAD [] xref: Reactome:R-HSA-9609507 "Protein localization" is_a: GO:0070727 ! cellular macromolecule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] synonym: "transcription regulator binding" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process is_a: BFO:0000015 ! process created_by: jl creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote_ribbon synonym: "metabolism" EXACT [] xref: Reactome:R-HSA-1430728 "Metabolism" xref: Wikipedia:Metabolism is_a: GO:0009987 ! cellular process disjoint_from: GO:0044848 ! biological phase disjoint_from: GO:0051179 ! localization created_by: jl creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008188 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity relationship: BFO:0000050 GO:0007218 ! part of neuropeptide signaling pathway relationship: BFO:0000051 GO:0042923 ! has part neuropeptide binding [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] synonym: "steroid metabolism" EXACT [] xref: Reactome:R-HSA-8957322 "Metabolism of steroids" xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35341 ! has primary input or output steroid relationship: RO:0004007 CHEBI:35341 ! has primary input or output steroid [Term] id: GO:0008217 name: regulation of blood pressure namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure homeostasis" RELATED [] synonym: "blood pressure regulation" EXACT [] synonym: "control of blood pressure" RELATED [] xref: Wikipedia:Blood_pressure#Regulation is_a: GO:0065008 ! regulation of biological quality relationship: BFO:0000050 GO:0008015 ! part of blood circulation [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. subset: gocheck_do_not_annotate synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0008227 name: G protein-coupled amine receptor activity namespace: molecular_function def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "biogenic amine receptor" NARROW [] synonym: "G-protein coupled amine receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function alt_id: GO:0070010 alt_id: GO:0070011 def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [EC:3.4.-.-, GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptidase activity, acting on D-amino acid peptides" NARROW [] synonym: "peptidase activity, acting on L-amino acid peptides" NARROW [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4.-.- xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl" xref: Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl" xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" xref: Reactome:R-HSA-9935547 "Lysosomal degradation of ubiqutinated CDH1" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008277 name: regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007186 ! regulates G protein-coupled receptor signaling pathway relationship: RO:0002211 GO:0007186 ! regulates G protein-coupled receptor signaling pathway [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008283 ! positively regulates cell population proliferation relationship: RO:0002213 GO:0008283 ! positively regulates cell population proliferation [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation relationship: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Binding to a lipid." [GOC:ai] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:1900619 ! acetate ester metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15355 ! has primary input or output relationship: RO:0004007 CHEBI:15355 ! has primary input or output [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:1900620 ! acetate ester biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:15355 ! has primary output relationship: RO:0004008 CHEBI:15355 ! has primary output [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process alt_id: GO:0009241 def: "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] synonym: "protein channel activity" RELATED [] xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix" xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)" xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)" xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol" xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol" xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol" xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation" xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation" xref: Reactome:R-HSA-9760705 "GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space" is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:0140318 ! protein transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000050 GO:0071806 ! part of protein transmembrane transport [Term] id: GO:0008347 name: glial cell migration namespace: biological_process def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] synonym: "glia cell migration" EXACT [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000125 ! results in movement of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0002565 CL:0000125 ! results in movement of glial cell [Term] id: GO:0008354 name: germ cell migration namespace: biological_process def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] synonym: "germ-cell migration" EXACT [] synonym: "pole cell migration" NARROW [] synonym: "primordial germ cell migration" RELATED [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000586 ! results in movement of germ cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0002565 CL:0000586 ! results in movement of germ cell [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008366 name: axon ensheathment namespace: biological_process def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] synonym: "cellular axon ensheathment" EXACT [] synonym: "cellular nerve ensheathment" RELATED [] synonym: "nerve ensheathment" RELATED [] is_a: GO:0007272 ! ensheathment of neurons relationship: RO:0000057 GO:0030424 ! has participant axon [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] synonym: "gonadogenesis" EXACT [GOC:cjm] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000991 ! results in development of gonad relationship: BFO:0000050 GO:0045137 ! part of development of primary sexual characteristics relationship: RO:0002296 UBERON:0000991 ! results in development of gonad [Term] id: GO:0008502 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:16796 ! has primary input relationship: RO:0004009 CHEBI:16796 ! has primary input [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah] xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines" xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol" is_a: GO:0022804 ! active transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:63534 ! has primary input relationship: BFO:0000050 GO:0015844 ! part of monoamine transport relationship: RO:0004009 CHEBI:63534 ! has primary input [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" xref: Reactome:R-HSA-561041 "OAT1,2,3 transport organic anions with antiport of dicarboxylic acids" xref: Reactome:R-HSA-9794830 "SLC22A8 transports Cipro into renal cell" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25696 ! has primary input organic anion relationship: BFO:0000050 GO:0015711 ! part of organic anion transport relationship: RO:0004009 CHEBI:25696 ! has primary input organic anion [Term] id: GO:0008528 name: G protein-coupled peptide receptor activity namespace: molecular_function def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001653 ! peptide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development [Term] id: GO:0008585 name: female gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] synonym: "ovarian development" RELATED [GOC:sl] synonym: "ovary development" RELATED [GOC:sl] is_a: GO:0008406 ! gonad development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000992 ! results in development of ovary relationship: BFO:0000050 GO:0046545 ! part of development of primary female sexual characteristics relationship: RO:0002296 UBERON:0000992 ! results in development of ovary [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell relationship: BFO:0000050 GO:0042461 ! part of photoreceptor cell development relationship: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18059 ! has primary output lipid relationship: RO:0004008 CHEBI:18059 ! has primary output lipid [Term] id: GO:0008641 name: ubiquitin-like modifier activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "small protein activating enzyme activity" NARROW [] is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds is_a: GO:0140096 ! catalytic activity, acting on a protein is_a: GO:0140657 ! ATP-dependent activity [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "sugar transport" NARROW [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0008652 name: amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] synonym: "amino acid anabolism" EXACT [] synonym: "amino acid biosynthesis" EXACT [] synonym: "amino acid formation" EXACT [] synonym: "amino acid synthesis" EXACT [] synonym: "cellular amino acid biosynthetic process" EXACT [] xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35238 ! has primary output amino-acid zwitterion relationship: RO:0004008 CHEBI:35238 ! has primary output amino-acid zwitterion [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_plant subset: goslim_plant_ribbon synonym: "breakdown of chemical" EXACT [] synonym: "breakdown of molecule" EXACT [] synonym: "breakdown of substance" EXACT [] synonym: "catabolism" EXACT [] synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule catabolic process" RELATED [] synonym: "cellular macromolecule catabolism" RELATED [] synonym: "cellular macromolecule degradation" RELATED [] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0009056 ! catabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule relationship: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33694 ! has primary output biomacromolecule relationship: RO:0004008 CHEBI:33694 ! has primary output biomacromolecule [Term] id: GO:0009063 name: amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid breakdown" EXACT [] synonym: "amino acid catabolism" EXACT [] synonym: "amino acid degradation" EXACT [] synonym: "cellular amino acid catabolic process" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid metabolism" EXACT [] xref: Reactome:R-HSA-8964539 "Glutamate and glutamine metabolism" is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24318 ! has primary input or output glutamine family amino acid relationship: RO:0004007 CHEBI:24318 ! has primary input or output glutamine family amino acid [Term] id: GO:0009065 name: glutamine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid breakdown" EXACT [] synonym: "glutamine family amino acid catabolism" EXACT [] synonym: "glutamine family amino acid degradation" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0170035 ! L-amino acid catabolic process is_a: GO:0170040 ! proteinogenic amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24318 ! has primary input glutamine family amino acid relationship: RO:0004009 CHEBI:24318 ! has primary input glutamine family amino acid [Term] id: GO:0009067 name: aspartate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid anabolism" EXACT [] synonym: "aspartate family amino acid biosynthesis" EXACT [] synonym: "aspartate family amino acid formation" EXACT [] synonym: "aspartate family amino acid synthesis" EXACT [] is_a: GO:0170034 ! L-amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process [Term] id: GO:0009069 name: serine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26650 ! has primary input or output relationship: RO:0004007 CHEBI:26650 ! has primary input or output [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26650 ! has primary output relationship: RO:0004008 CHEBI:26650 ! has primary output [Term] id: GO:0009071 name: serine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid breakdown" EXACT [] synonym: "serine family amino acid catabolism" EXACT [] synonym: "serine family amino acid degradation" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:26650 ! has primary input relationship: RO:0004009 CHEBI:26650 ! has primary input [Term] id: GO:0009084 name: glutamine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid anabolism" EXACT [] synonym: "glutamine family amino acid biosynthesis" EXACT [] synonym: "glutamine family amino acid formation" EXACT [] synonym: "glutamine family amino acid synthesis" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0170034 ! L-amino acid biosynthetic process is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24318 ! has primary output glutamine family amino acid relationship: RO:0004008 CHEBI:24318 ! has primary output glutamine family amino acid [Term] id: GO:0009085 name: lysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine anabolism" EXACT [] synonym: "lysine biosynthesis" EXACT [] synonym: "lysine formation" EXACT [] synonym: "lysine synthesis" EXACT [] xref: MetaCyc:LYSINE-SYN is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: goslim_drosophila synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:17089 ! has primary input or output relationship: RO:0004007 CHEBI:17089 ! has primary input or output [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [https://www.ncbi.nlm.nih.gov/books/NBK579918/] subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:17089 ! has primary output relationship: RO:0004008 CHEBI:17089 ! has primary output [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] synonym: "nucleobase metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase relationship: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] xref: Wikipedia:Nucleoid is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process alt_id: GO:0044106 def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] synonym: "cellular amine metabolic process" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:32952 ! has primary input or output amine relationship: RO:0004007 CHEBI:32952 ! has primary input or output amine created_by: jl creation_date: 2009-07-15T11:55:44Z [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0009308 ! amine metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:32952 ! has primary output amine relationship: RO:0004008 CHEBI:32952 ! has primary output amine [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0009308 ! amine metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process [Term] id: GO:0009404 name: toxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] subset: goslim_pir synonym: "toxin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: goslim_plant is_a: GO:0009314 ! response to radiation intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:30212 ! has primary input relationship: RO:0004009 CHEBI:30212 ! has primary input [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732] comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. synonym: "4-aminobutanoate metabolic process" EXACT [] synonym: "4-aminobutanoate metabolism" EXACT [] synonym: "4-aminobutyrate metabolic process" EXACT [] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolic process" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:59888 ! has primary input or output relationship: RO:0004007 CHEBI:59888 ! has primary input or output [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. synonym: "4-aminobutanoate biosynthesis" EXACT [] synonym: "4-aminobutanoate biosynthetic process" EXACT [] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "4-aminobutyrate biosynthetic process" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "GABA biosynthetic process" EXACT [] synonym: "gamma-aminobutyric acid anabolism" EXACT [] synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] xref: Reactome:R-HSA-888568 "GABA synthesis" is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:59888 ! has primary output relationship: RO:0004008 CHEBI:59888 ! has primary output [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. synonym: "4-aminobutanoate catabolic process" EXACT [] synonym: "4-aminobutanoate catabolism" EXACT [] synonym: "4-aminobutyrate catabolic process" EXACT [] synonym: "4-aminobutyrate catabolism" EXACT [] synonym: "GABA catabolic process" EXACT [] synonym: "GABA catabolism" EXACT [] synonym: "gamma-aminobutyric acid breakdown" EXACT [] synonym: "gamma-aminobutyric acid catabolism" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY xref: Reactome:R-HSA-916853 "Degradation of GABA" is_a: GO:0009063 ! amino acid catabolic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid [Term] id: GO:0009508 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943088399] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0042646 ! part of plastid nucleoid [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0009536 ! part of plastid [Term] id: GO:0009527 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] is_a: GO:0031968 ! organelle outer membrane is_a: GO:0042170 ! plastid membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0009536 ! bounding layer of plastid relationship: RO:0002007 GO:0009536 ! bounding layer of plastid [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:0943088399] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0009536 ! part of plastid [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0009547 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] is_a: GO:0000313 ! organellar ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0009532 ! part of plastid stroma [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process intersection_of: GO:0022414 ! reproductive process intersection_of: RO:0002297 CL:0010017 ! results in formation of zygote intersection_of: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction relationship: RO:0002297 CL:0010017 ! results in formation of zygote relationship: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma relationship: BFO:0000050 GO:0009507 ! part of chloroplast [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "chemoreception" RELATED [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0051606 ! detection of stimulus relationship: BFO:0000050 GO:0042221 ! part of response to chemical [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009620 name: response to fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: GO:0051707 ! response to other organism intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi relationship: RO:0004009 NCBITaxon:4751 ! has primary input Fungi [Term] id: GO:0009626 name: plant-type hypersensitive response namespace: biological_process def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider using 'effector-mediated activation of plant hypersensitive response by symbiont' ; GO:0080185. synonym: "HR" BROAD [] synonym: "HR-PCD" EXACT [] synonym: "plant hypersensitive response" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034050 ! symbiont-induced defense-related programmed cell death is_a: GO:0045087 ! innate immune response [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process disjoint_from: GO:0048856 ! anatomical structure development disjoint_from: GO:0071695 ! anatomical structure maturation relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development [Term] id: GO:0009657 name: plastid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] subset: goslim_pir synonym: "plastid organisation" EXACT [] synonym: "plastid organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0009536 ! results in organization of plastid relationship: RO:0002592 GO:0009536 ! results in organization of plastid [Term] id: GO:0009658 name: chloroplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] synonym: "chloroplast organisation" EXACT [] synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0009507 ! results in organization of chloroplast relationship: RO:0002592 GO:0009507 ! results in organization of chloroplast [Term] id: GO:0009665 name: plastid inheritance namespace: biological_process def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] is_a: GO:0009657 ! plastid organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: GOREL:0002003 GO:0009536 ! results in distribution of plastid relationship: GOREL:0002003 GO:0009536 ! results in distribution of plastid [Term] id: GO:0009666 name: plastid outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid outer membrane organisation" EXACT [] synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0009527 ! results in organization of plastid outer membrane relationship: RO:0002592 GO:0009527 ! results in organization of plastid outer membrane [Term] id: GO:0009668 name: plastid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid membrane organisation" EXACT [] synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042170 ! results in organization of plastid membrane relationship: BFO:0000050 GO:0009657 ! part of plastid organization relationship: RO:0002592 GO:0042170 ! results in organization of plastid membrane [Term] id: GO:0009707 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0031969 ! chloroplast membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0009507 ! bounding layer of chloroplast relationship: RO:0002007 GO:0009507 ! bounding layer of chloroplast [Term] id: GO:0009712 name: catechol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] synonym: "catechol metabolic process" RELATED [] synonym: "catechol metabolism" RELATED [] is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33566 ! has primary input or output relationship: RO:0004007 CHEBI:33566 ! has primary input or output [Term] id: GO:0009713 name: catechol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol anabolism" RELATED [] synonym: "catechol biosynthesis" RELATED [] synonym: "catechol biosynthetic process" RELATED [] synonym: "catechol formation" RELATED [] synonym: "catechol synthesis" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33566 ! has primary output relationship: RO:0004008 CHEBI:33566 ! has primary output [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0042221 ! response to chemical [Term] id: GO:0009743 name: response to carbohydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: BFO:0000050 GO:0032870 ! part of cellular response to hormone stimulus [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008356 ! regulates asymmetric cell division relationship: RO:0002211 GO:0008356 ! regulates asymmetric cell division [Term] id: GO:0009790 name: embryo development namespace: biological_process def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Reactome:R-HSA-5619507 "Activation of HOX genes during differentiation" xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000922 ! results in development of embryo relationship: RO:0002296 UBERON:0000922 ! results in development of embryo [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0009847 name: spore germination namespace: biological_process alt_id: GO:0075005 def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] synonym: "spore germination on or near host" NARROW [] is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0009880 name: embryonic pattern specification namespace: biological_process def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] synonym: "embryonic pattern biosynthesis" BROAD [] synonym: "embryonic pattern formation" BROAD [] synonym: "ventral/lateral system" RELATED [] is_a: GO:0007389 ! pattern specification process relationship: BFO:0000050 GO:0009790 ! part of embryo development [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000479 ! results in development of tissue relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002296 UBERON:0000479 ! results in development of tissue [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009058 ! regulates biosynthetic process relationship: RO:0002211 GO:0009058 ! regulates biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process relationship: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009058 ! positively regulates biosynthetic process relationship: RO:0002213 GO:0009058 ! positively regulates biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008152 ! negatively regulates metabolic process relationship: RO:0002212 GO:0008152 ! negatively regulates metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008152 ! positively regulates metabolic process relationship: RO:0002213 GO:0008152 ! positively regulates metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process relationship: RO:0002211 GO:0009056 ! regulates catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009056 ! negatively regulates catabolic process relationship: RO:0002212 GO:0009056 ! negatively regulates catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009056 ! positively regulates catabolic process relationship: RO:0002213 GO:0009056 ! positively regulates catabolic process [Term] id: GO:0009902 name: chloroplast relocation namespace: biological_process def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] is_a: GO:0009658 ! chloroplast organization is_a: GO:0019750 ! chloroplast localization is_a: GO:0051667 ! establishment of plastid localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0009507 ! has primary input chloroplast [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell relationship: BFO:0000050 GO:0008544 ! part of epidermis development relationship: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope relationship: BFO:0000050 GO:0009507 ! part of chloroplast [Term] id: GO:0009952 name: anterior/posterior pattern specification namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern formation" RELATED [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007165 ! regulates signal transduction relationship: RO:0002211 GO:0007165 ! regulates signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007165 ! positively regulates signal transduction relationship: RO:0002213 GO:0007165 ! positively regulates signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] xref: Reactome:R-HSA-8849472 "PTK6 Down-Regulation" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007165 ! negatively regulates signal transduction relationship: RO:0002212 GO:0007165 ! negatively regulates signal transduction [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast relationship: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast [Term] id: GO:0010020 name: chloroplast fission namespace: biological_process def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] synonym: "chloroplast division" EXACT [] is_a: GO:0009658 ! chloroplast organization is_a: GO:0043572 ! plastid fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0009507 ! results in fission of chloroplast relationship: GOREL:0002004 GO:0009507 ! results in fission of chloroplast [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0030261 ! chromosome condensation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000365 ! has primary input animal zygote relationship: RO:0004009 CL:0000365 ! has primary input animal zygote [Term] id: GO:0010160 name: formation of animal organ boundary namespace: biological_process def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048859 ! formation of anatomical boundary intersection_of: BFO:0000066 UBERON:0000062 ! occurs in organ relationship: BFO:0000050 GO:0048645 ! part of animal organ formation relationship: BFO:0000066 UBERON:0000062 ! occurs in organ [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism relationship: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] subset: goslim_drosophila synonym: "endomembrane organization" EXACT [] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0012505 ! results in organization of endomembrane system relationship: RO:0002592 GO:0012505 ! results in organization of endomembrane system [Term] id: GO:0010324 name: membrane invagination namespace: biological_process alt_id: GO:1902534 def: "The infolding of a membrane." [GOC:tb] subset: goslim_yeast synonym: "single-organism membrane invagination" RELATED [] is_a: GO:0061024 ! membrane organization created_by: jl creation_date: 2013-12-02T13:58:34Z [Term] id: GO:0010363 name: regulation of plant-type hypersensitive response namespace: biological_process def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. synonym: "regulation of HR" EXACT [] synonym: "regulation of HR-PCD" EXACT [] synonym: "regulation of plant hypersensitive response" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009626 ! regulates plant-type hypersensitive response relationship: RO:0002211 GO:0009626 ! regulates plant-type hypersensitive response [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045165 ! regulates cell fate commitment relationship: RO:0002211 GO:0045165 ! regulates cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment relationship: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045165 ! positively regulates cell fate commitment relationship: RO:0002213 GO:0045165 ! positively regulates cell fate commitment [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell relationship: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation relationship: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. subset: goslim_euk_cellular_processes_ribbon subset: goslim_plant_ribbon synonym: "gene regulation" RELATED [GOC:cjm] synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Reactome:R-HSA-163767 "PP2A-mediated dephosphorylation of key metabolic factors" xref: Reactome:R-HSA-9752946 "Expression and translocation of olfactory receptors" xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010467 ! regulates gene expression relationship: RO:0002211 GO:0010467 ! regulates gene expression [Term] id: GO:0010469 name: regulation of signaling receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "regulation of receptor activity" BROAD [] synonym: "regulation of signalling receptor activity" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0038023 ! regulates signaling receptor activity relationship: RO:0002211 GO:0038023 ! regulates signaling receptor activity [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007369 ! regulates gastrulation relationship: RO:0002211 GO:0007369 ! regulates gastrulation [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000362 ! has primary input epidermal cell relationship: RO:0004009 CL:0000362 ! has primary input epidermal cell [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010481 ! regulates epidermal cell division relationship: RO:0002211 GO:0010481 ! regulates epidermal cell division [Term] id: GO:0010496 name: intercellular transport namespace: biological_process def: "The movement of substances between cells." [GOC:dhl] synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intercellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 CL:0000000 ! has target start location cell intersection_of: RO:0002339 CL:0000000 ! has target end location cell intersection_of: RO:0002342 GO:0005615 ! results in transport across extracellular space relationship: RO:0002338 CL:0000000 ! has target start location cell relationship: RO:0002339 CL:0000000 ! has target end location cell relationship: RO:0002342 GO:0005615 ! results in transport across extracellular space creation_date: 2013-12-19T13:24:56Z [Term] id: GO:0010506 name: regulation of autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006914 ! regulates autophagy relationship: RO:0002211 GO:0006914 ! regulates autophagy [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030397 ! regulates membrane disassembly relationship: RO:0002211 GO:0030397 ! regulates membrane disassembly [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process relationship: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process relationship: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process relationship: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process relationship: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process relationship: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process relationship: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006793 ! positively regulates phosphorus metabolic process relationship: RO:0002213 GO:0006793 ! positively regulates phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006793 ! negatively regulates phosphorus metabolic process relationship: RO:0002212 GO:0006793 ! negatively regulates phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022402 ! regulates cell cycle process relationship: RO:0002211 GO:0022402 ! regulates cell cycle process [Term] id: GO:0010565 name: regulation of ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042180 ! regulates ketone metabolic process relationship: RO:0002211 GO:0042180 ! regulates ketone metabolic process [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010565 ! regulation of ketone metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process relationship: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process [Term] id: GO:0010570 name: regulation of filamentous growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0040008 ! regulation of growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030447 ! regulates filamentous growth relationship: RO:0002211 GO:0030447 ! regulates filamentous growth [Term] id: GO:0010594 name: regulation of endothelial cell migration namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043542 ! regulates endothelial cell migration relationship: RO:0002211 GO:0043542 ! regulates endothelial cell migration [Term] id: GO:0010595 name: positive regulation of endothelial cell migration namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration relationship: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration [Term] id: GO:0010596 name: negative regulation of endothelial cell migration namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration relationship: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process relationship: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process relationship: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process [Term] id: GO:0010608 name: post-transcriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] synonym: "posttranscriptional regulation of gene expression" EXACT [] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010611 name: regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy relationship: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy [Term] id: GO:0010612 name: regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation relationship: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation [Term] id: GO:0010613 name: positive regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014742 ! positive regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy relationship: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy [Term] id: GO:0010614 name: negative regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014741 ! negative regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy relationship: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy [Term] id: GO:0010615 name: positive regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014744 ! positive regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation relationship: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation [Term] id: GO:0010616 name: negative regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014745 ! negative regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation relationship: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0012501 ! programmed cell death intersection_of: BFO:0000050 GO:0048468 ! part of cell development relationship: BFO:0000050 GO:0048468 ! part of cell development [Term] id: GO:0010624 name: regulation of Schwann cell proliferation namespace: biological_process def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014010 ! regulates Schwann cell proliferation relationship: RO:0002211 GO:0014010 ! regulates Schwann cell proliferation [Term] id: GO:0010625 name: positive regulation of Schwann cell proliferation namespace: biological_process def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060252 ! positive regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014010 ! positively regulates Schwann cell proliferation relationship: RO:0002213 GO:0014010 ! positively regulates Schwann cell proliferation [Term] id: GO:0010626 name: negative regulation of Schwann cell proliferation namespace: biological_process def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060253 ! negative regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014010 ! negatively regulates Schwann cell proliferation relationship: RO:0002212 GO:0014010 ! negatively regulates Schwann cell proliferation [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010467 ! positively regulates gene expression relationship: RO:0002213 GO:0010467 ! positively regulates gene expression [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. synonym: "gene silencing" RELATED [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010467 ! negatively regulates gene expression relationship: RO:0002212 GO:0010467 ! negatively regulates gene expression [Term] id: GO:0010631 name: epithelial cell migration namespace: biological_process def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000066 ! results in movement of epithelial cell relationship: BFO:0000050 GO:0090132 ! part of epithelium migration relationship: RO:0002565 CL:0000066 ! results in movement of epithelial cell [Term] id: GO:0010632 name: regulation of epithelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010631 ! regulates epithelial cell migration relationship: RO:0002211 GO:0010631 ! regulates epithelial cell migration [Term] id: GO:0010633 name: negative regulation of epithelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010631 ! negatively regulates epithelial cell migration relationship: RO:0002212 GO:0010631 ! negatively regulates epithelial cell migration [Term] id: GO:0010634 name: positive regulation of epithelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010631 ! positively regulates epithelial cell migration relationship: RO:0002213 GO:0010631 ! positively regulates epithelial cell migration [Term] id: GO:0010635 name: regulation of mitochondrial fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008053 ! regulates mitochondrial fusion relationship: RO:0002211 GO:0008053 ! regulates mitochondrial fusion [Term] id: GO:0010636 name: positive regulation of mitochondrial fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008053 ! positively regulates mitochondrial fusion relationship: RO:0002213 GO:0008053 ! positively regulates mitochondrial fusion [Term] id: GO:0010637 name: negative regulation of mitochondrial fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008053 ! negatively regulates mitochondrial fusion relationship: RO:0002212 GO:0008053 ! negatively regulates mitochondrial fusion [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] subset: gocheck_do_not_annotate synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006996 ! positively regulates organelle organization relationship: RO:0002213 GO:0006996 ! positively regulates organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] subset: gocheck_do_not_annotate synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006996 ! negatively regulates organelle organization relationship: RO:0002212 GO:0006996 ! negatively regulates organelle organization [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007154 ! regulates cell communication relationship: RO:0002211 GO:0007154 ! regulates cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007154 ! positively regulates cell communication relationship: RO:0002213 GO:0007154 ! positively regulates cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007154 ! negatively regulates cell communication relationship: RO:0002212 GO:0007154 ! negatively regulates cell communication [Term] id: GO:0010656 name: negative regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "negative regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process relationship: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process [Term] id: GO:0010657 name: muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "muscle cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0010658 name: striated muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "striated muscle cell apoptosis" NARROW [] is_a: GO:0010657 ! muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000737 ! occurs in striated muscle cell relationship: BFO:0000066 CL:0000737 ! occurs in striated muscle cell [Term] id: GO:0010659 name: cardiac muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010658 ! striated muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell [Term] id: GO:0010660 name: regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of muscle cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process relationship: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process [Term] id: GO:0010661 name: positive regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process relationship: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process [Term] id: GO:0010662 name: regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process relationship: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process [Term] id: GO:0010663 name: positive regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process relationship: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process [Term] id: GO:0010664 name: negative regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process relationship: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process [Term] id: GO:0010665 name: regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process relationship: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process [Term] id: GO:0010666 name: positive regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process relationship: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process [Term] id: GO:0010667 name: negative regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process relationship: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process [Term] id: GO:0010668 name: ectodermal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell relationship: BFO:0000050 GO:0007398 ! part of ectoderm development relationship: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell [Term] id: GO:0010700 name: negative regulation of norepinephrine secretion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion relationship: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion [Term] id: GO:0010701 name: positive regulation of norepinephrine secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion relationship: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion [Term] id: GO:0010710 name: regulation of collagen catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030574 ! regulates collagen catabolic process relationship: RO:0002211 GO:0030574 ! regulates collagen catabolic process [Term] id: GO:0010711 name: negative regulation of collagen catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010713 ! negative regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process relationship: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process [Term] id: GO:0010712 name: regulation of collagen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032963 ! regulates collagen metabolic process relationship: RO:0002211 GO:0032963 ! regulates collagen metabolic process [Term] id: GO:0010713 name: negative regulation of collagen metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process relationship: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process [Term] id: GO:0010714 name: positive regulation of collagen metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process relationship: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process [Term] id: GO:0010715 name: regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly relationship: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly [Term] id: GO:0010716 name: negative regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly relationship: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly [Term] id: GO:0010717 name: regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition relationship: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition [Term] id: GO:0010718 name: positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition relationship: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition [Term] id: GO:0010719 name: negative regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition relationship: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048468 ! positively regulates cell development relationship: RO:0002213 GO:0048468 ! positively regulates cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048468 ! negatively regulates cell development relationship: RO:0002212 GO:0048468 ! negatively regulates cell development [Term] id: GO:0010758 name: regulation of macrophage chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048246 ! regulates macrophage chemotaxis relationship: RO:0002211 GO:0048246 ! regulates macrophage chemotaxis [Term] id: GO:0010759 name: positive regulation of macrophage chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:1905523 ! positive regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048246 ! positively regulates macrophage chemotaxis relationship: RO:0002213 GO:0048246 ! positively regulates macrophage chemotaxis [Term] id: GO:0010760 name: negative regulation of macrophage chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:1905522 ! negative regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048246 ! negatively regulates macrophage chemotaxis relationship: RO:0002212 GO:0048246 ! negatively regulates macrophage chemotaxis [Term] id: GO:0010761 name: fibroblast migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] synonym: "fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000057 ! results in movement of fibroblast relationship: RO:0002565 CL:0000057 ! results in movement of fibroblast [Term] id: GO:0010762 name: regulation of fibroblast migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010761 ! regulates fibroblast migration relationship: RO:0002211 GO:0010761 ! regulates fibroblast migration [Term] id: GO:0010763 name: positive regulation of fibroblast migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010761 ! positively regulates fibroblast migration relationship: RO:0002213 GO:0010761 ! positively regulates fibroblast migration [Term] id: GO:0010764 name: negative regulation of fibroblast migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010761 ! negatively regulates fibroblast migration relationship: RO:0002212 GO:0010761 ! negatively regulates fibroblast migration [Term] id: GO:0010770 name: positive regulation of cell morphogenesis namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis relationship: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis [Term] id: GO:0010771 name: negative regulation of cell morphogenesis namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis relationship: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010818 name: T cell chemotaxis namespace: biological_process def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] synonym: "T-cell chemotaxis" EXACT [CL:0000084] is_a: GO:0048247 ! lymphocyte chemotaxis is_a: GO:0072678 ! T cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000084 ! results in movement of T cell [Term] id: GO:0010819 name: regulation of T cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010818 ! regulates T cell chemotaxis relationship: RO:0002211 GO:0010818 ! regulates T cell chemotaxis [Term] id: GO:0010820 name: positive regulation of T cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010819 ! regulation of T cell chemotaxis is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000406 ! positive regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010818 ! positively regulates T cell chemotaxis relationship: RO:0002213 GO:0010818 ! positively regulates T cell chemotaxis [Term] id: GO:0010821 name: regulation of mitochondrion organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007005 ! regulates mitochondrion organization relationship: RO:0002211 GO:0007005 ! regulates mitochondrion organization [Term] id: GO:0010830 name: regulation of myotube differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014902 ! regulates myotube differentiation relationship: RO:0002211 GO:0014902 ! regulates myotube differentiation [Term] id: GO:0010831 name: positive regulation of myotube differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014902 ! positively regulates myotube differentiation relationship: RO:0002213 GO:0014902 ! positively regulates myotube differentiation [Term] id: GO:0010832 name: negative regulation of myotube differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation relationship: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation [Term] id: GO:0010842 name: retina layer formation namespace: biological_process def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001781 ! results in formation of layer of retina relationship: BFO:0000050 GO:0003407 ! part of neural retina development relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye relationship: RO:0002297 UBERON:0001781 ! results in formation of layer of retina [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0010892 name: positive regulation of mitochondrial translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070131 ! positive regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation [Term] id: GO:0010893 name: positive regulation of steroid biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process relationship: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process [Term] id: GO:0010894 name: negative regulation of steroid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process relationship: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0032989 ! part of cellular anatomical entity morphogenesis [Term] id: GO:0010934 name: macrophage cytokine production namespace: biological_process def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0061082 ! myeloid leukocyte cytokine production intersection_of: GO:0001816 ! cytokine production intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage [Term] id: GO:0010935 name: regulation of macrophage cytokine production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010934 ! regulates macrophage cytokine production relationship: RO:0002211 GO:0010934 ! regulates macrophage cytokine production [Term] id: GO:0010936 name: negative regulation of macrophage cytokine production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0010935 ! regulation of macrophage cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010934 ! negatively regulates macrophage cytokine production relationship: RO:0002212 GO:0010934 ! negatively regulates macrophage cytokine production [Term] id: GO:0010937 name: regulation of cytoplasmic microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] is_a: GO:0031114 ! regulation of microtubule depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization relationship: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022402 ! negatively regulates cell cycle process relationship: RO:0002212 GO:0022402 ! negatively regulates cell cycle process creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010958 name: regulation of amino acid import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb] synonym: "regulation of amino acid import" BROAD [] is_a: GO:1903789 ! regulation of amino acid transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0089718 ! regulates amino acid import across plasma membrane relationship: RO:0002211 GO:0089718 ! regulates amino acid import across plasma membrane creation_date: 2009-05-06T11:33:12Z [Term] id: GO:0010968 name: regulation of microtubule nucleation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0031113 ! regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007020 ! regulates microtubule nucleation relationship: RO:0002211 GO:0007020 ! regulates microtubule nucleation creation_date: 2009-05-20T11:51:21Z [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: RO:0002341 GO:0005874 ! results in transport along microtubule creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031175 ! regulates neuron projection development relationship: RO:0002211 GO:0031175 ! regulates neuron projection development creation_date: 2009-06-01T10:44:45Z [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031175 ! positively regulates neuron projection development relationship: RO:0002213 GO:0031175 ! positively regulates neuron projection development creation_date: 2009-06-01T10:46:44Z [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031175 ! negatively regulates neuron projection development relationship: RO:0002212 GO:0031175 ! negatively regulates neuron projection development creation_date: 2009-06-01T10:47:42Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_prokaryote synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Reactome:R-HSA-5357801 "Programmed Cell Death" xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death intersection_of: GO:0008219 ! cell death intersection_of: RO:0002224 GO:0007165 ! starts with signal transduction relationship: RO:0002224 GO:0007165 ! starts with signal transduction [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell relationship: BFO:0000051 GO:0005773 ! has part vacuole relationship: BFO:0000051 GO:0005886 ! has part plasma membrane [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0031982 ! part of vesicle relationship: BFO:0000050 GO:0031982 ! part of vesicle [Term] id: GO:0014000 name: morula development namespace: biological_process def: "The process whose specific outcome is the progression of the morula over time. The morula is a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745] is_a: GO:0009790 ! embryo development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000085 ! results in development of morula relationship: RO:0002296 UBERON:0000085 ! results in development of morula creation_date: 2024-11-12T09:13:07Z [Term] id: GO:0014002 name: astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] synonym: "astrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000127 ! results in development of astrocyte relationship: BFO:0000050 GO:0048708 ! part of astrocyte differentiation relationship: RO:0002296 CL:0000127 ! results in development of astrocyte [Term] id: GO:0014003 name: oligodendrocyte development namespace: biological_process def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] synonym: "oligodendrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000128 ! results in development of oligodendrocyte relationship: BFO:0000050 GO:0048709 ! part of oligodendrocyte differentiation relationship: RO:0002296 CL:0000128 ! results in development of oligodendrocyte [Term] id: GO:0014004 name: microglia differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] synonym: "microglial cell differentiation" EXACT [] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0030225 ! macrophage differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000129 ! results in acquisition of features of microglial cell relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:0000129 ! results in acquisition of features of microglial cell [Term] id: GO:0014005 name: microglia development namespace: biological_process def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] synonym: "microglial cell development" EXACT [] is_a: GO:0021782 ! glial cell development is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000129 ! results in development of microglial cell relationship: BFO:0000050 GO:0014004 ! part of microglia differentiation relationship: RO:0002296 CL:0000129 ! results in development of microglial cell [Term] id: GO:0014006 name: regulation of microglia differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "regulation of microglial cell differentiation" EXACT [] is_a: GO:0045649 ! regulation of macrophage differentiation is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014004 ! regulates microglia differentiation relationship: RO:0002211 GO:0014004 ! regulates microglia differentiation [Term] id: GO:0014007 name: negative regulation of microglia differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "down regulation of microglia differentiation" EXACT [] synonym: "down-regulation of microglia differentiation" EXACT [] synonym: "downregulation of microglia differentiation" EXACT [] synonym: "inhibition of microglia differentiation" NARROW [] synonym: "negative regulation of microglial cell differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045650 ! negative regulation of macrophage differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014004 ! negatively regulates microglia differentiation relationship: RO:0002212 GO:0014004 ! negatively regulates microglia differentiation [Term] id: GO:0014008 name: positive regulation of microglia differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "activation of microglia differentiation" NARROW [] synonym: "positive regulation of microglial cell differentiation" EXACT [] synonym: "stimulation of microglia differentiation" NARROW [] synonym: "up regulation of microglia differentiation" EXACT [] synonym: "up-regulation of microglia differentiation" EXACT [] synonym: "upregulation of microglia differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045651 ! positive regulation of macrophage differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014004 ! positively regulates microglia differentiation relationship: RO:0002213 GO:0014004 ! positively regulates microglia differentiation [Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] synonym: "glia proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000125 ! acts on population of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0012003 CL:0000125 ! acts on population of glial cell [Term] id: GO:0014010 name: Schwann cell proliferation namespace: biological_process def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014009 ! glial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000218 ! acts on population of myelinating Schwann cell relationship: RO:0012003 CL:0000218 ! acts on population of myelinating Schwann cell [Term] id: GO:0014013 name: regulation of gliogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] is_a: GO:0050767 ! regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042063 ! regulates gliogenesis relationship: RO:0002211 GO:0042063 ! regulates gliogenesis [Term] id: GO:0014014 name: negative regulation of gliogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "down regulation of gliogenesis" EXACT [] synonym: "down-regulation of gliogenesis" EXACT [] synonym: "downregulation of gliogenesis" EXACT [] synonym: "inhibition of gliogenesis" NARROW [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042063 ! negatively regulates gliogenesis relationship: RO:0002212 GO:0042063 ! negatively regulates gliogenesis [Term] id: GO:0014015 name: positive regulation of gliogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "activation of gliogenesis" NARROW [] synonym: "stimulation of gliogenesis" NARROW [] synonym: "up regulation of gliogenesis" EXACT [] synonym: "up-regulation of gliogenesis" EXACT [] synonym: "upregulation of gliogenesis" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042063 ! positively regulates gliogenesis relationship: RO:0002213 GO:0042063 ! positively regulates gliogenesis [Term] id: GO:0014016 name: neuroblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata) [Term] id: GO:0014019 name: neuroblast development namespace: biological_process def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0014016 ! part of neuroblast differentiation relationship: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata) [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780] synonym: "neural rod cavitation" RELATED [] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: BFO:0000050 GO:0001841 ! part of neural tube formation [Term] id: GO:0014023 name: neural rod formation namespace: biological_process def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005068 ! results in formation of neural rod relationship: BFO:0000050 GO:0014020 ! part of primary neural tube formation relationship: RO:0002162 NCBITaxon:32443 ! in taxon Teleostei relationship: RO:0002297 UBERON:0005068 ! results in formation of neural rod [Term] id: GO:0014025 name: neural keel formation namespace: biological_process def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007135 ! results in formation of neural keel relationship: BFO:0000050 GO:0014023 ! part of neural rod formation relationship: RO:0002297 UBERON:0007135 ! results in formation of neural keel [Term] id: GO:0014028 name: notochord formation namespace: biological_process def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002328 ! results in formation of notochord relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: BFO:0000050 GO:0048570 ! part of notochord morphogenesis relationship: RO:0002297 UBERON:0002328 ! results in formation of notochord [Term] id: GO:0014029 name: neural crest formation namespace: biological_process def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:dh, GOC:ef] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002342 ! results in formation of neural crest relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002297 UBERON:0002342 ! results in formation of neural crest [Term] id: GO:0014031 name: mesenchymal cell development namespace: biological_process def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0008019 ! results in development of mesenchymal cell relationship: BFO:0000050 GO:0048762 ! part of mesenchymal cell differentiation relationship: RO:0002296 CL:0008019 ! results in development of mesenchymal cell [Term] id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048864 ! stem cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0011012 ! results in development of neural crest cell relationship: BFO:0000050 GO:0014033 ! part of neural crest cell differentiation relationship: RO:0002296 CL:0011012 ! results in development of neural crest cell [Term] id: GO:0014033 name: neural crest cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell [Term] id: GO:0014037 name: Schwann cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000218 ! results in acquisition of features of myelinating Schwann cell relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002315 CL:0000218 ! results in acquisition of features of myelinating Schwann cell [Term] id: GO:0014038 name: regulation of Schwann cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014037 ! regulates Schwann cell differentiation relationship: RO:0002211 GO:0014037 ! regulates Schwann cell differentiation [Term] id: GO:0014039 name: negative regulation of Schwann cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "down regulation of Schwann cell differentiation" EXACT [] synonym: "down-regulation of Schwann cell differentiation" EXACT [] synonym: "downregulation of Schwann cell differentiation" EXACT [] synonym: "inhibition of Schwann cell differentiation" NARROW [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014037 ! negatively regulates Schwann cell differentiation relationship: RO:0002212 GO:0014037 ! negatively regulates Schwann cell differentiation [Term] id: GO:0014040 name: positive regulation of Schwann cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "activation of Schwann cell differentiation" NARROW [] synonym: "stimulation of Schwann cell differentiation" NARROW [] synonym: "up regulation of Schwann cell differentiation" EXACT [] synonym: "up-regulation of Schwann cell differentiation" EXACT [] synonym: "upregulation of Schwann cell differentiation" EXACT [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014037 ! positively regulates Schwann cell differentiation relationship: RO:0002213 GO:0014037 ! positively regulates Schwann cell differentiation [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042551 ! regulates neuron maturation relationship: RO:0002211 GO:0042551 ! regulates neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:1903431 ! positive regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042551 ! positively regulates neuron maturation relationship: RO:0002213 GO:0042551 ! positively regulates neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:1903430 ! negative regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042551 ! negatively regulates neuron maturation relationship: RO:0002212 GO:0042551 ! negatively regulates neuron maturation [Term] id: GO:0014044 name: Schwann cell development namespace: biological_process def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] is_a: GO:0021782 ! glial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000218 ! results in development of myelinating Schwann cell relationship: BFO:0000050 GO:0014037 ! part of Schwann cell differentiation relationship: RO:0002296 CL:0000218 ! results in development of myelinating Schwann cell [Term] id: GO:0014047 name: glutamate secretion namespace: biological_process def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0014048 name: regulation of glutamate secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014047 ! regulates glutamate secretion relationship: RO:0002211 GO:0014047 ! regulates glutamate secretion [Term] id: GO:0014049 name: positive regulation of glutamate secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "activation of glutamate secretion" NARROW [] synonym: "stimulation of glutamate secretion" NARROW [] synonym: "up regulation of glutamate secretion" EXACT [] synonym: "up-regulation of glutamate secretion" EXACT [] synonym: "upregulation of glutamate secretion" EXACT [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014047 ! positively regulates glutamate secretion relationship: RO:0002213 GO:0014047 ! positively regulates glutamate secretion [Term] id: GO:0014050 name: negative regulation of glutamate secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "down regulation of glutamate secretion" EXACT [] synonym: "down-regulation of glutamate secretion" EXACT [] synonym: "downregulation of glutamate secretion" EXACT [] synonym: "inhibition of glutamate secretion" NARROW [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014047 ! negatively regulates glutamate secretion relationship: RO:0002212 GO:0014047 ! negatively regulates glutamate secretion [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] synonym: "GABA secretion" EXACT [] is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0046717 ! acid secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0014052 name: regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "regulation of GABA secretion" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051046 ! regulation of secretion is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014051 ! regulates gamma-aminobutyric acid secretion relationship: RO:0002211 GO:0014051 ! regulates gamma-aminobutyric acid secretion [Term] id: GO:0014053 name: negative regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] synonym: "negative regulation of GABA secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014051 ! negatively regulates gamma-aminobutyric acid secretion relationship: RO:0002212 GO:0014051 ! negatively regulates gamma-aminobutyric acid secretion [Term] id: GO:0014054 name: positive regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] synonym: "positive regulation of GABA secretion" EXACT [] synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014051 ! positively regulates gamma-aminobutyric acid secretion relationship: RO:0002213 GO:0014051 ! positively regulates gamma-aminobutyric acid secretion [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission namespace: biological_process def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion intersection_of: GO:0061526 ! acetylcholine secretion intersection_of: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic [Term] id: GO:0014056 name: regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission relationship: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014057 name: positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "activation of acetylcholine secretion" NARROW [] synonym: "stimulation of acetylcholine secretion" NARROW [] synonym: "up regulation of acetylcholine secretion" EXACT [] synonym: "up-regulation of acetylcholine secretion" EXACT [] synonym: "upregulation of acetylcholine secretion" EXACT [] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission relationship: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014058 name: negative regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "down regulation of acetylcholine secretion" EXACT [] synonym: "down-regulation of acetylcholine secretion" EXACT [] synonym: "downregulation of acetylcholine secretion" EXACT [] synonym: "inhibition of acetylcholine secretion" NARROW [] is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission relationship: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission [Term] id: GO:0014061 name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048243 ! regulates norepinephrine secretion relationship: RO:0002211 GO:0048243 ! regulates norepinephrine secretion [Term] id: GO:0014062 name: regulation of serotonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001820 ! regulates serotonin secretion relationship: RO:0002211 GO:0001820 ! regulates serotonin secretion [Term] id: GO:0014063 name: negative regulation of serotonin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "down regulation of serotonin secretion" EXACT [] synonym: "down-regulation of serotonin secretion" EXACT [] synonym: "downregulation of serotonin secretion" EXACT [] synonym: "inhibition of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043271 ! negative regulation of monoatomic ion transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion relationship: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion [Term] id: GO:0014064 name: positive regulation of serotonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "activation of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] synonym: "stimulation of serotonin secretion" NARROW [] synonym: "up regulation of serotonin secretion" EXACT [] synonym: "up-regulation of serotonin secretion" EXACT [] synonym: "upregulation of serotonin secretion" EXACT [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043270 ! positive regulation of monoatomic ion transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001820 ! positively regulates serotonin secretion relationship: RO:0002213 GO:0001820 ! positively regulates serotonin secretion [Term] id: GO:0014075 name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0014706 name: striated muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] is_a: GO:0060537 ! muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue relationship: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue [Term] id: GO:0014733 name: regulation of skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation relationship: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation [Term] id: GO:0014734 name: skeletal muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014897 ! striated muscle hypertrophy is_a: GO:0043501 ! skeletal muscle adaptation intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue [Term] id: GO:0014741 name: negative regulation of muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy relationship: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy [Term] id: GO:0014742 name: positive regulation of muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy relationship: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy [Term] id: GO:0014743 name: regulation of muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014896 ! regulates muscle hypertrophy relationship: RO:0002211 GO:0014896 ! regulates muscle hypertrophy [Term] id: GO:0014744 name: positive regulation of muscle adaptation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "positive regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043500 ! positively regulates muscle adaptation relationship: RO:0002213 GO:0043500 ! positively regulates muscle adaptation [Term] id: GO:0014745 name: negative regulation of muscle adaptation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "negative regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation relationship: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation [Term] id: GO:0014805 name: smooth muscle adaptation namespace: biological_process def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "smooth muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001756 ! regulates somitogenesis relationship: RO:0002211 GO:0001756 ! regulates somitogenesis [Term] id: GO:0014812 name: muscle cell migration namespace: biological_process def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000187 ! results in movement of muscle cell relationship: RO:0002565 CL:0000187 ! results in movement of muscle cell [Term] id: GO:0014819 name: regulation of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0006942 ! regulation of striated muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction relationship: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction [Term] id: GO:0014852 name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014855 name: striated muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] is_a: GO:0033002 ! muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000737 ! acts on population of striated muscle cell relationship: RO:0012003 CL:0000737 ! acts on population of striated muscle cell [Term] id: GO:0014856 name: skeletal muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0014855 ! striated muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle relationship: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle [Term] id: GO:0014857 name: regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation relationship: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation [Term] id: GO:0014858 name: positive regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation relationship: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation [Term] id: GO:0014859 name: negative regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation relationship: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation [Term] id: GO:0014860 name: neurotransmitter secretion involved in regulation of skeletal muscle contraction namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: BFO:0000050 GO:0014819 ! part of regulation of skeletal muscle contraction relationship: BFO:0000050 GO:0014852 ! part of regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014861 name: regulation of skeletal muscle contraction via regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential relationship: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential [Term] id: GO:0014866 name: skeletal myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] is_a: GO:0030239 ! myofibril assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril relationship: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril [Term] id: GO:0014872 name: myoblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000056 ! has primary input myoblast relationship: RO:0004009 CL:0000056 ! has primary input myoblast [Term] id: GO:0014874 name: response to stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation relationship: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation [Term] id: GO:0014887 name: cardiac muscle adaptation namespace: biological_process def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] synonym: "cardiac muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue [Term] id: GO:0014888 name: striated muscle adaptation namespace: biological_process def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "striated muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue [Term] id: GO:0014895 name: smooth muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014896 ! muscle hypertrophy intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue [Term] id: GO:0014896 name: muscle hypertrophy namespace: biological_process def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] xref: Wikipedia:Muscle_hypertrophy is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue [Term] id: GO:0014897 name: striated muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014896 ! muscle hypertrophy intersection_of: GO:0014896 ! muscle hypertrophy intersection_of: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue relationship: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue [Term] id: GO:0014902 name: myotube differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0051146 ! striated muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002372 ! results in acquisition of features of myotube relationship: RO:0002315 CL:0002372 ! results in acquisition of features of myotube [Term] id: GO:0014904 name: myotube cell development namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0055002 ! striated muscle cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0002372 ! results in development of myotube relationship: BFO:0000050 GO:0014902 ! part of myotube differentiation relationship: RO:0002296 CL:0002372 ! results in development of myotube [Term] id: GO:0014909 name: smooth muscle cell migration namespace: biological_process def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell relationship: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell [Term] id: GO:0014910 name: regulation of smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014909 ! regulates smooth muscle cell migration relationship: RO:0002211 GO:0014909 ! regulates smooth muscle cell migration [Term] id: GO:0014911 name: positive regulation of smooth muscle cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014909 ! positively regulates smooth muscle cell migration relationship: RO:0002213 GO:0014909 ! positively regulates smooth muscle cell migration [Term] id: GO:0014912 name: negative regulation of smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014909 ! negatively regulates smooth muscle cell migration relationship: RO:0002212 GO:0014909 ! negatively regulates smooth muscle cell migration [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_chembl subset: goslim_pir subset: goslim_yeast synonym: "enzyme transport" NARROW [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0015075 name: monoatomic ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "ion transmembrane transporter activity" BROAD [] synonym: "ion transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion relationship: BFO:0000050 GO:0034220 ! part of monoatomic ion transmembrane transport relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion [Term] id: GO:0015101 name: organic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" xref: Reactome:R-HSA-9794270 "SLCO1A2 transports Cipro(1+) into the cytosol" xref: Reactome:R-HSA-9794523 "SLC22A1 transports Cipro into renal cell" xref: Reactome:R-HSA-9795207 "SLC22A1 transports Cipro into hepatic cell" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:25697 ! has primary input organic cation relationship: BFO:0000050 GO:0015695 ! part of organic cation transport relationship: RO:0004009 CHEBI:25697 ! has primary input organic cation [Term] id: GO:0015144 name: carbohydrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "carbohydrate transporter activity" RELATED [] synonym: "sugar transporter" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: BFO:0000050 GO:0034219 ! part of carbohydrate transmembrane transport relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0015159 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:R-HSA-9932121 "Unknown transporter exports CA to extracellular space" xref: Reactome:R-HSA-9932466 "Bcs complex exports pEtN-cellulose" is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: BFO:0000050 GO:0015774 ! part of polysaccharide transport relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0015171 name: amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes" xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons" xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol" xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol" xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol" xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane" xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: BFO:0000050 GO:0003333 ! part of amino acid transmembrane transport relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0015172 name: acidic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "acidic amino acid transporter activity" BROAD [] xref: Reactome:R-HSA-372448 "SLC25A12,13 exchange L-Glu and L-Asp" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: BFO:0000050 GO:0015800 ! part of acidic amino acid transport [Term] id: GO:0015175 name: neutral L-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "neutral amino acid transmembrane transporter activity" EXACT [] synonym: "neutral amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: BFO:0000050 GO:0015804 ! part of neutral amino acid transport [Term] id: GO:0015179 name: L-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "L-amino acid transporter activity" BROAD [] xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes" xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion relationship: BFO:0000050 GO:1902475 ! part of L-alpha-amino acid transmembrane transport relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion [Term] id: GO:0015185 name: gamma-aminobutyric acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: BFO:0000050 GO:0015812 ! part of gamma-aminobutyric acid transport relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0015187 name: glycine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: BFO:0000050 GO:0015816 ! part of glycine transport relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0015464 name: acetylcholine receptor activity namespace: molecular_function def: "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic relationship: BFO:0000051 GO:0042166 ! has part acetylcholine binding relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015631 name: tubulin binding namespace: molecular_function def: "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0015669 name: gas transport namespace: biological_process def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0015671 name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] xref: Reactome:R-HSA-8981607 "Intracellular oxygen transport" is_a: GO:0015669 ! gas transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:15379 ! has primary input relationship: RO:0004009 CHEBI:15379 ! has primary input [Term] id: GO:0015695 name: organic cation transport namespace: biological_process def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25697 ! has primary input organic cation relationship: RO:0004009 CHEBI:25697 ! has primary input organic cation [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24834 ! has primary input inorganic anion relationship: RO:0004009 CHEBI:24834 ! has primary input inorganic anion [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:25696 ! has primary input organic anion relationship: RO:0004009 CHEBI:25696 ! has primary input organic anion [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion [Term] id: GO:0015774 name: polysaccharide transport namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: BFO:0000050 GO:0033037 ! part of polysaccharide localization relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0015800 name: acidic amino acid transport namespace: biological_process def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport namespace: biological_process def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015807 name: L-amino acid transport namespace: biological_process def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] is_a: GO:0006865 ! amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion [Term] id: GO:0015812 name: gamma-aminobutyric acid transport namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. synonym: "4-aminobutanoate transport" EXACT [] synonym: "4-aminobutyrate transport" EXACT [] synonym: "GABA transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0015813 name: L-glutamate transmembrane transport namespace: biological_process def: "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582] synonym: "L-glutamate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0051938 ! L-glutamate import is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0015816 name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0015844 name: monoamine transport namespace: biological_process def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:63534 ! has primary input relationship: RO:0004009 CHEBI:63534 ! has primary input [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0015850 name: organic hydroxy compound transport namespace: biological_process def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai] synonym: "organic alcohol transport" EXACT [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33822 ! has primary input organic hydroxy compound relationship: RO:0004009 CHEBI:33822 ! has primary input organic hydroxy compound [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase [Term] id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0015874 name: norepinephrine transport namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity [Term] id: GO:0015932 name: nucleobase-containing compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity relationship: BFO:0000050 GO:0015931 ! part of nucleobase-containing compound transport relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity [Term] id: GO:0016020 name: membrane namespace: cellular_component alt_id: GO:0016021 alt_id: GO:0098589 alt_id: GO:0098805 def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "integral component of membrane" NARROW [] synonym: "integral to membrane" NARROW [] synonym: "membrane region" NARROW [] synonym: "region of membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] synonym: "whole membrane" NARROW [] xref: Wikipedia:Biological_membrane xref: Wikipedia:Transmembrane_protein is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0031012 ! extracellular matrix creation_date: 2014-03-06T11:37:54Z [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process alt_id: GO:0006724 alt_id: GO:0044240 def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] synonym: "multicellular organism lipid catabolic process" NARROW [] synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0005575 ! results in organization of cellular_component relationship: RO:0002592 GO:0005575 ! results in organization of cellular_component [Term] id: GO:0016049 name: cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_drosophila subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000000 ! results in growth of cell relationship: RO:0002343 CL:0000000 ! results in growth of cell [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031982 ! results in organization of vesicle relationship: RO:0002592 GO:0031982 ! results in organization of vesicle [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16646 ! has primary output carbohydrate relationship: RO:0004008 CHEBI:16646 ! has primary output carbohydrate [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] synonym: "single-organism carbohydrate catabolic process" RELATED [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate creation_date: 2012-10-23T16:34:39Z [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:64709 ! has primary output organic acid relationship: RO:0004008 CHEBI:64709 ! has primary output organic acid [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044282 ! small molecule catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell namespace: biological_process def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential intersection_of: GO:0042391 ! regulation of membrane potential intersection_of: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell relationship: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_prokaryote synonym: "RNA metabolism" EXACT [] xref: Reactome:R-HSA-8953854 "Metabolism of RNA" is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33697 ! has primary input or output ribonucleic acid relationship: RO:0004007 CHEBI:33697 ! has primary input or output ribonucleic acid [Term] id: GO:0016106 name: sesquiterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid anabolism" EXACT [] synonym: "sesquiterpenoid biosynthesis" EXACT [] synonym: "sesquiterpenoid formation" EXACT [] synonym: "sesquiterpenoid synthesis" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016114 name: terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid anabolism" EXACT [] synonym: "terpenoid biosynthesis" EXACT [] synonym: "terpenoid formation" EXACT [] synonym: "terpenoid synthesis" EXACT [] xref: Wikipedia:Terpenoid is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle relationship: RO:0002608 GO:0031982 ! process has causal agent vesicle [Term] id: GO:0016202 name: regulation of striated muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014706 ! regulates striated muscle tissue development relationship: RO:0002211 GO:0014706 ! regulates striated muscle tissue development [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339] synonym: "autophagy" BROAD [] synonym: "selective autophagy" NARROW [] xref: Reactome:R-HSA-1632852 "Macroautophagy" xref: Reactome:R-HSA-5205685 "PINK1-PRKN Mediated Mitophagy" xref: Reactome:R-HSA-8934903 "Receptor Mediated Mitophagy" is_a: GO:0006914 ! autophagy relationship: BFO:0000051 GO:0000045 ! has part autophagosome assembly [Term] id: GO:0016241 name: regulation of macroautophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016236 ! regulates macroautophagy relationship: RO:0002211 GO:0016236 ! regulates macroautophagy [Term] id: GO:0016301 name: kinase activity def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. synonym: "phosphokinase activity" EXACT [] xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" is_a: GO:0003674 ! molecular_function [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: gocheck_obsoletion_candidate subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: BFO:0000050 GO:0007143 ! part of female meiotic nuclear division relationship: BFO:0000050 GO:0007143 ! part of female meiotic nuclear division [Term] id: GO:0016325 name: oocyte microtubule cytoskeleton organization namespace: biological_process def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000023 ! occurs in oocyte intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton relationship: BFO:0000050 GO:0007308 ! part of oocyte construction relationship: BFO:0000066 CL:0000023 ! occurs in oocyte [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016358 name: dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0031175 ! neuron projection development is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 GO:0030425 ! results in development of dendrite relationship: RO:0002296 GO:0030425 ! results in development of dendrite [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility [Term] id: GO:0016482 name: cytosolic transport namespace: biological_process def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol relationship: BFO:0000066 GO:0005829 ! occurs in cytosol [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001525 ! negatively regulates angiogenesis relationship: RO:0002212 GO:0001525 ! negatively regulates angiogenesis [Term] id: GO:0016528 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: Wikipedia:Sarcoplasm is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 CL:0000187 ! part of muscle cell [Term] id: GO:0016594 name: glycine binding namespace: molecular_function def: "Binding to glycine, aminoethanoic acid." [GOC:ai] synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input [Term] id: GO:0016595 name: glutamate binding namespace: molecular_function def: "Binding to glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] synonym: "glutamic acid binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0031406 ! carboxylic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0016597 name: amino acid binding namespace: molecular_function def: "Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:2.-.-.- xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5333607 "GSSeH combines with bGalNAc derivative to form GSSebGalNac" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016746 name: acyltransferase activity namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-] subset: goslim_chembl subset: goslim_drosophila synonym: "transferase activity, transferring acyl groups" EXACT [] xref: EC:2.3.-.- xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016755 name: aminoacyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "transferase activity, transferring amino-acyl groups" EXACT [] xref: EC:2.3.2.- is_a: GO:0016746 ! acyltransferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote subset: goslim_yeast xref: EC:3.-.-.- xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" xref: Reactome:R-HSA-9942295 "QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2.-.- xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan" xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan" xref: Reactome:R-HSA-5333609 "MeSebGalNac is hydrolysed to MeSeH and bGalNac" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6.-.- is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] xref: EC:3.6.1.- xref: Reactome:R-HSA-9731590 "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP" xref: Reactome:R-HSA-9731613 "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP" xref: Reactome:R-HSA-9731632 "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP" is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6.-.-.- is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.-.-] synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2.-.- is_a: GO:0016874 ! ligase activity [Term] id: GO:0016887 name: ATP hydrolysis activity namespace: molecular_function alt_id: GO:0004002 alt_id: GO:0042623 def: "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function. synonym: "adenosine 5'-triphosphatase activity" EXACT [] synonym: "adenosine triphosphatase activity" EXACT [] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [] synonym: "ATP monophosphatase activity" RELATED [] synonym: "ATP phosphohydrolase activity" EXACT [] xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70" xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90" xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" xref: Reactome:R-HSA-917693 "ESCRT Disassembly" xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP" xref: Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex" xref: Reactome:R-HSA-9948300 "RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide" xref: Reactome:R-HSA-9949632 "VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide" xref: Reactome:R-HSA-9955731 "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide" xref: RHEA:13065 is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity relationship: BFO:0000050 GO:0140657 ! part of ATP-dependent activity [Term] id: GO:0016907 name: G protein-coupled acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled acetylcholine receptor activity" EXACT [] synonym: "G-protein coupled acetylcholine receptor activity" EXACT [] synonym: "metabotropic acetylcholine receptor activity" EXACT [] synonym: "muscarinic acetylcholine receptor activity" EXACT [] xref: Reactome:R-HSA-400012 "Acetylcholine binds Muscarinic Acetylcholine Receptor M3" is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0015464 ! acetylcholine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: BFO:0000050 GO:0007213 ! part of G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0016917 name: GABA receptor activity namespace: molecular_function def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650] comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. synonym: "4-aminobutanoate receptor activity" EXACT [] synonym: "4-aminobutyrate receptor activity" EXACT [] synonym: "GABA binding" EXACT [] synonym: "gamma-aminobutyrate binding" EXACT [] synonym: "gamma-aminobutyric acid binding" EXACT [] synonym: "gamma-aminobutyric acid receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0017046 name: peptide hormone binding namespace: molecular_function def: "Binding to a peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732] synonym: "polypeptide hormone binding" EXACT [] is_a: GO:0033218 ! amide binding is_a: GO:0042562 ! hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:25905 ! has primary input relationship: RO:0004009 CHEBI:25905 ! has primary input [Term] id: GO:0017111 name: ribonucleoside triphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [] synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" BROAD [] synonym: "nucleoside triphosphate hydrolase activity" BROAD [] synonym: "nucleoside triphosphate phosphatase activity" BROAD [] synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED [] synonym: "nucleoside-triphosphatase activity" BROAD [] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" xref: RHEA:23680 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017126 name: nucleologenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0005730 ! has primary output nucleolus relationship: RO:0004008 GO:0005730 ! has primary output nucleolus [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell relationship: RO:0004009 CL:0000034 ! has primary input stem cell [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation relationship: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006887 ! regulates exocytosis relationship: RO:0002211 GO:0006887 ! regulates exocytosis [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [] xref: UM-BBD_pathwayID:phe is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33853 ! has primary input or output phenols relationship: RO:0004007 CHEBI:33853 ! has primary input or output phenols [Term] id: GO:0018995 name: host cellular component namespace: cellular_component def: "Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732] synonym: "host organism" EXACT [] xref: Wikipedia:Host_(biology) is_a: GO:0044217 ! other organism part [Term] id: GO:0019093 name: mitochondrial RNA localization namespace: biological_process def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] synonym: "mitochondrial RNA localisation" EXACT [GOC:mah] synonym: "mtRNA localization" EXACT [] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] synonym: "multi-organism reproductive behavior" NARROW [] synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior intersection_of: GO:0048609 ! multicellular organismal reproductive process creation_date: 2012-09-19T16:01:37Z [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] xref: Reactome:R-HSA-2426168 "Activation of gene expression by SREBF (SREBP)" xref: Reactome:R-HSA-400206 "Regulation of lipid metabolism by PPARalpha" is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006629 ! regulates lipid metabolic process relationship: RO:0002211 GO:0006629 ! regulates lipid metabolic process [Term] id: GO:0019218 name: regulation of steroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "regulation of steroid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008202 ! regulates steroid metabolic process relationship: RO:0002211 GO:0008202 ! regulates steroid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process relationship: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006796 ! regulates phosphate-containing compound metabolic process relationship: RO:0002211 GO:0006796 ! regulates phosphate-containing compound metabolic process [Term] id: GO:0019221 name: cytokine-mediated signaling pathway namespace: biological_process def: "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "cytokine mediated signalling pathway" EXACT [] xref: Reactome:R-HSA-449147 "Signaling by Interleukins" xref: Reactome:R-HSA-913531 "Interferon Signaling" xref: Reactome:R-HSA-9607240 "FLT3 Signaling" xref: Reactome:R-HSA-9674555 "Signaling by CSF3 (G-CSF)" xref: Reactome:R-HSA-9680350 "Signaling by CSF1 (M-CSF) in myeloid cells" is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: BFO:0000050 GO:0071345 ! part of cellular response to cytokine stimulus [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] xref: Reactome:R-HSA-1989781 "PPARA activates gene expression" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008152 ! regulates metabolic process relationship: RO:0002211 GO:0008152 ! regulates metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse namespace: biological_process def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] synonym: "conduction of nerve impulse" EXACT [GOC:dph] synonym: "signal transmission along a neuron" EXACT [] is_a: GO:0050877 ! nervous system process relationship: BFO:0000050 GO:0007154 ! part of cell communication relationship: BFO:0000051 GO:0001508 ! has part action potential relationship: BFO:0000051 GO:0007268 ! has part chemical synaptic transmission [Term] id: GO:0019228 name: neuronal action potential namespace: biological_process def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000050 GO:0019226 ! part of transmission of nerve impulse relationship: BFO:0000066 CL:0000540 ! occurs in neuron [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system." [GOC:curators] synonym: "nociception" RELATED [] synonym: "perception of physiological pain" NARROW [] xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception [Term] id: GO:0019336 name: phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] synonym: "phenol-containing compound breakdown" EXACT [] synonym: "phenol-containing compound catabolism" EXACT [] synonym: "phenol-containing compound degradation" EXACT [] xref: MetaCyc:PHENOLDEG-PWY is_a: GO:0009056 ! catabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33853 ! has primary input phenols relationship: RO:0004009 CHEBI:33853 ! has primary input phenols [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044267 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "cellular protein metabolic process" EXACT [] synonym: "cellular protein metabolism" EXACT [] synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Reactome:R-HSA-392499 "Metabolism of proteins" xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000000001 ! has primary input or output protein relationship: RO:0004007 PR:000000001 ! has primary input or output protein [Term] id: GO:0019614 name: catechol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol breakdown" RELATED [] synonym: "catechol catabolic process" RELATED [] synonym: "catechol catabolism" RELATED [] synonym: "catechol degradation" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33566 ! has primary input relationship: RO:0004009 CHEBI:33566 ! has primary input [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_candida subset: goslim_euk_cellular_processes_ribbon subset: goslim_plant is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: BFO:0000066 CL:0000000 ! occurs in cell disjoint_from: GO:0048872 ! homeostasis of number of cells relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0019747 name: regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] synonym: "regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006720 ! regulates isoprenoid metabolic process relationship: RO:0002211 GO:0006720 ! regulates isoprenoid metabolic process [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_pombe synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019750 name: chloroplast localization namespace: biological_process def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732] synonym: "chloroplast localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0009507 ! has primary input chloroplast relationship: RO:0004009 GO:0009507 ! has primary input chloroplast [Term] id: GO:0019751 name: polyol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [PMID:30240188] synonym: "polyhydric alcohol metabolic process" EXACT [] synonym: "polyol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] xref: Reactome:R-HSA-389661 "Glyoxylate metabolism and glycine degradation" is_a: GO:0043436 ! oxoacid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:29067 ! has primary input or output carboxylic acid anion relationship: RO:0004007 CHEBI:29067 ! has primary input or output carboxylic acid anion [Term] id: GO:0019755 name: one-carbon compound transport namespace: biological_process def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "one carbon compound transport" EXACT [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:64708 ! has primary input one-carbon compound relationship: RO:0004009 CHEBI:64708 ! has primary input one-carbon compound [Term] id: GO:0019777 name: Atg12 transferase activity namespace: molecular_function def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" NARROW [] synonym: "APG12 ligase activity" NARROW [] synonym: "Atg12 conjugating enzyme activity" NARROW [] synonym: "Atg12 ligase activity" NARROW [] xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019778 name: Atg12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019786 name: protein-phosphatidylethanolamide deconjugating activity namespace: molecular_function def: "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328] synonym: "APG8-PE hydrolase" RELATED [] synonym: "APG8-specific protease activity" NARROW [GOC:vw] synonym: "ATG8-PE deconjugation activity" NARROW [] synonym: "ATG8-PE hydrolase activity" NARROW [] synonym: "Atg8-specific peptidase activity" NARROW [] synonym: "Atg8-specific protease activity" EXACT [] is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019787 name: ubiquitin-like protein transferase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: goslim_drosophila subset: goslim_pir synonym: "E2" BROAD [] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] synonym: "small protein conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" is_a: GO:0016755 ! aminoacyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019825 name: oxygen binding namespace: molecular_function def: "Binding to oxygen (O2)." [GOC:jl] subset: goslim_pir subset: goslim_plant synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:15379 ! has primary input relationship: RO:0004009 CHEBI:15379 ! has primary input [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0009987 ! cellular process [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019882 name: antigen processing and presentation namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation" EXACT [] synonym: "antigen processing" EXACT [] xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019896 name: axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] subset: goslim_synapse synonym: "axon transport of mitochondria" EXACT [] is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098930 ! axonal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. subset: gocheck_do_not_annotate xref: Wikipedia:Sexual_reproduction is_a: GO:0022414 ! reproductive process [Term] id: GO:0019954 name: asexual reproduction namespace: biological_process def: "A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells." [ISBN:0387520546, PMID:22977071, PMID:28779329, PMID:29559496] synonym: "parthenogenesis" RELATED [Wikipedia:Parthenogenesis] xref: Wikipedia:Asexual_reproduction is_a: GO:0022414 ! reproductive process [Term] id: GO:0019955 name: cytokine binding namespace: molecular_function def: "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "IL binding" NARROW [] synonym: "interleukin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0021501 name: prechordal plate formation namespace: biological_process def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003063 ! results in formation of prechordal plate relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002297 UBERON:0003063 ! results in formation of prechordal plate [Term] id: GO:0021508 name: floor plate formation namespace: biological_process def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003079 ! results in formation of floor plate relationship: BFO:0000050 GO:0007418 ! part of ventral midline development relationship: BFO:0000050 GO:0033505 ! part of floor plate morphogenesis relationship: RO:0002297 UBERON:0003079 ! results in formation of floor plate [Term] id: GO:0021510 name: spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002240 ! results in development of spinal cord relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0002240 ! results in development of spinal cord [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord intersection_of: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron relationship: BFO:0000050 GO:0021517 ! part of ventral spinal cord development relationship: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron [Term] id: GO:0021515 name: cell differentiation in spinal cord namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: BFO:0000066 UBERON:0002240 ! occurs in spinal cord [Term] id: GO:0021517 name: ventral spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord [Term] id: GO:0021522 name: spinal cord motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron relationship: BFO:0000050 GO:0021517 ! part of ventral spinal cord development relationship: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron [Term] id: GO:0021523 name: somatic motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021522 ! spinal cord motor neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron relationship: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron [Term] id: GO:0021531 name: spinal cord radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16185248] synonym: "radial glial cell differentiation in spinal cord" EXACT [] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0060019 ! radial glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000073 ! results in acquisition of features of spinal cord radial glial cell relationship: RO:0002315 CL:1000073 ! results in acquisition of features of spinal cord radial glial cell [Term] id: GO:0021532 name: neural tube patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0003002 ! regionalization relationship: BFO:0000050 GO:0021915 ! part of neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain [Term] id: GO:0021534 name: cell proliferation in hindbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain [Term] id: GO:0021535 name: cell migration in hindbrain namespace: biological_process def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain [Term] id: GO:0021536 name: diencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001894 ! results in development of diencephalon relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001894 ! results in development of diencephalon [Term] id: GO:0021537 name: telencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001893 ! results in development of telencephalon relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002296 UBERON:0001893 ! results in development of telencephalon [Term] id: GO:0021538 name: epithalamus development namespace: biological_process def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001899 ! results in development of epithalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: RO:0002296 UBERON:0001899 ! results in development of epithalamus [Term] id: GO:0021543 name: pallium development namespace: biological_process def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000203 ! results in development of pallium relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002296 UBERON:0000203 ! results in development of pallium [Term] id: GO:0021544 name: subpallium development namespace: biological_process def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000204 ! results in development of ventral part of telencephalon relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002296 UBERON:0000204 ! results in development of ventral part of telencephalon [Term] id: GO:0021545 name: cranial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021675 ! nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001785 ! results in development of cranial nerve relationship: RO:0002296 UBERON:0001785 ! results in development of cranial nerve [Term] id: GO:0021546 name: rhombomere development namespace: biological_process def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001892 ! results in development of rhombomere relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0001892 ! results in development of rhombomere [Term] id: GO:0021547 name: midbrain-hindbrain boundary initiation namespace: biological_process def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513] synonym: "isthmus biosynthesis" RELATED [GOC:cls] synonym: "isthmus formation" RELATED [GOC:cls] synonym: "MHB biosynthesis" EXACT [GOC:cls] synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003052 ! results in formation of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0021999 ! part of neural plate anterior/posterior regionalization relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development relationship: RO:0002297 UBERON:0003052 ! results in formation of midbrain-hindbrain boundary [Term] id: GO:0021548 name: pons development namespace: biological_process def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000988 ! results in development of pons relationship: BFO:0000050 GO:0022037 ! part of metencephalon development relationship: RO:0002296 UBERON:0000988 ! results in development of pons [Term] id: GO:0021549 name: cerebellum development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002037 ! results in development of cerebellum relationship: BFO:0000050 GO:0022037 ! part of metencephalon development relationship: RO:0002296 UBERON:0002037 ! results in development of cerebellum [Term] id: GO:0021550 name: medulla oblongata development namespace: biological_process def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla development" RELATED [GOC:cls] synonym: "myelencephalon development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata [Term] id: GO:0021551 name: central nervous system morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system [Term] id: GO:0021555 name: midbrain-hindbrain boundary morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] synonym: "isthmus morphogenesis" EXACT [GOC:cls] synonym: "MHB morphogenesis" EXACT [GOC:cls] is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development relationship: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary [Term] id: GO:0021556 name: central nervous system formation namespace: biological_process def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001017 ! results in formation of central nervous system relationship: BFO:0000050 GO:0021551 ! part of central nervous system morphogenesis relationship: RO:0002297 UBERON:0001017 ! results in formation of central nervous system [Term] id: GO:0021559 name: trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V development" RELATED [GOC:cls] synonym: "cranial nerve 5 development" EXACT [GOC:cls] synonym: "cranial nerve V development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve relationship: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve [Term] id: GO:0021563 name: glossopharyngeal nerve development namespace: biological_process def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX development" RELATED [GOC:cls] synonym: "cranial nerve 9 development" EXACT [GOC:cls] synonym: "cranial nerve IX development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001649 ! results in development of glossopharyngeal nerve relationship: RO:0002296 UBERON:0001649 ! results in development of glossopharyngeal nerve [Term] id: GO:0021564 name: vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X development" RELATED [GOC:cls] synonym: "cranial nerve 10 development" RELATED [GOC:cls] synonym: "cranial nerve X development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001759 ! results in development of vagus nerve relationship: BFO:0000050 GO:0021783 ! part of preganglionic parasympathetic fiber development relationship: RO:0002296 UBERON:0001759 ! results in development of vagus nerve [Term] id: GO:0021565 name: accessory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI development" RELATED [GOC:cls] synonym: "cranial nerve 11 development" RELATED [GOC:cls] synonym: "cranial nerve XI development" EXACT [GOC:cls] synonym: "spinal accessory nerve development" EXACT [PMID:11533729] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002019 ! results in development of accessory XI nerve relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0002019 ! results in development of accessory XI nerve [Term] id: GO:0021566 name: hypoglossal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII development" RELATED [GOC:cls] synonym: "cranial nerve 12 development" RELATED [GOC:cls] synonym: "cranial nerve XII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001650 ! results in development of hypoglossal nerve relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002296 UBERON:0001650 ! results in development of hypoglossal nerve [Term] id: GO:0021567 name: rhombomere 1 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021546 ! rhombomere development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005499 ! results in development of rhombomere 1 relationship: RO:0002296 UBERON:0005499 ! results in development of rhombomere 1 [Term] id: GO:0021575 name: hindbrain morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "rhombencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain [Term] id: GO:0021576 name: hindbrain formation namespace: biological_process def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002028 ! results in formation of hindbrain relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002297 UBERON:0002028 ! results in formation of hindbrain [Term] id: GO:0021578 name: hindbrain maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain relationship: BFO:0000050 GO:0021626 ! part of central nervous system maturation relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain [Term] id: GO:0021579 name: medulla oblongata morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla morphogenesis" RELATED [] synonym: "myelencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata [Term] id: GO:0021580 name: medulla oblongata formation namespace: biological_process def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla biosynthesis" RELATED [] synonym: "medulla formation" RELATED [] synonym: "myelencephalon biosynthesis" RELATED [] synonym: "myelencephalon formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001896 ! results in formation of medulla oblongata relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation relationship: BFO:0000050 GO:0021579 ! part of medulla oblongata morphogenesis relationship: RO:0002297 UBERON:0001896 ! results in formation of medulla oblongata [Term] id: GO:0021582 name: medulla oblongata maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "medulla maturation" RELATED [] synonym: "myelencephalon maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation relationship: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata [Term] id: GO:0021583 name: pons morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons [Term] id: GO:0021584 name: pons formation namespace: biological_process def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000988 ! results in formation of pons relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis relationship: RO:0002297 UBERON:0000988 ! results in formation of pons [Term] id: GO:0021586 name: pons maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000988 ! results in maturation of pons relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation relationship: RO:0002299 UBERON:0000988 ! results in maturation of pons [Term] id: GO:0021587 name: cerebellum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002037 ! results in morphogenesis of cerebellum relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis relationship: RO:0002298 UBERON:0002037 ! results in morphogenesis of cerebellum [Term] id: GO:0021588 name: cerebellum formation namespace: biological_process def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002037 ! results in formation of cerebellum relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation relationship: BFO:0000050 GO:0021587 ! part of cerebellum morphogenesis relationship: RO:0002297 UBERON:0002037 ! results in formation of cerebellum [Term] id: GO:0021590 name: cerebellum maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002037 ! results in maturation of cerebellum relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation relationship: RO:0002299 UBERON:0002037 ! results in maturation of cerebellum [Term] id: GO:0021591 name: ventricular system development namespace: biological_process def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005281 ! results in development of ventricular system of central nervous system relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0005281 ! results in development of ventricular system of central nervous system [Term] id: GO:0021592 name: fourth ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002422 ! results in development of fourth ventricle relationship: BFO:0000050 GO:0021591 ! part of ventricular system development relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0002422 ! results in development of fourth ventricle [Term] id: GO:0021593 name: rhombomere morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere relationship: BFO:0000050 GO:0021546 ! part of rhombomere development relationship: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere [Term] id: GO:0021594 name: rhombomere formation namespace: biological_process def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001892 ! results in formation of rhombomere relationship: BFO:0000050 GO:0021593 ! part of rhombomere morphogenesis relationship: RO:0002297 UBERON:0001892 ! results in formation of rhombomere [Term] id: GO:0021602 name: cranial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development relationship: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve [Term] id: GO:0021603 name: cranial nerve formation namespace: biological_process def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001785 ! results in formation of cranial nerve relationship: BFO:0000050 GO:0021602 ! part of cranial nerve morphogenesis relationship: RO:0002297 UBERON:0001785 ! results in formation of cranial nerve [Term] id: GO:0021605 name: cranial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0021682 ! nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development relationship: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve [Term] id: GO:0021606 name: accessory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI maturation" RELATED [] synonym: "spinal accessory nerve maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002019 ! results in maturation of accessory XI nerve relationship: BFO:0000050 GO:0021565 ! part of accessory nerve development relationship: RO:0002299 UBERON:0002019 ! results in maturation of accessory XI nerve [Term] id: GO:0021607 name: accessory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002019 ! results in morphogenesis of accessory XI nerve relationship: BFO:0000050 GO:0021565 ! part of accessory nerve development relationship: RO:0002298 UBERON:0002019 ! results in morphogenesis of accessory XI nerve [Term] id: GO:0021608 name: accessory nerve formation namespace: biological_process def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XI biosynthesis" RELATED [] synonym: "CN XI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002019 ! results in formation of accessory XI nerve relationship: BFO:0000050 GO:0021607 ! part of accessory nerve morphogenesis relationship: RO:0002297 UBERON:0002019 ! results in formation of accessory XI nerve [Term] id: GO:0021614 name: glossopharyngeal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001649 ! results in maturation of glossopharyngeal nerve relationship: BFO:0000050 GO:0021563 ! part of glossopharyngeal nerve development relationship: RO:0002299 UBERON:0001649 ! results in maturation of glossopharyngeal nerve [Term] id: GO:0021615 name: glossopharyngeal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001649 ! results in morphogenesis of glossopharyngeal nerve relationship: BFO:0000050 GO:0021563 ! part of glossopharyngeal nerve development relationship: RO:0002298 UBERON:0001649 ! results in morphogenesis of glossopharyngeal nerve [Term] id: GO:0021616 name: glossopharyngeal nerve formation namespace: biological_process def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN IX biosynthesis" RELATED [] synonym: "CN IX formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001649 ! results in formation of glossopharyngeal nerve relationship: BFO:0000050 GO:0021615 ! part of glossopharyngeal nerve morphogenesis relationship: RO:0002297 UBERON:0001649 ! results in formation of glossopharyngeal nerve [Term] id: GO:0021618 name: hypoglossal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001650 ! results in morphogenesis of hypoglossal nerve relationship: BFO:0000050 GO:0021566 ! part of hypoglossal nerve development relationship: RO:0002298 UBERON:0001650 ! results in morphogenesis of hypoglossal nerve [Term] id: GO:0021619 name: hypoglossal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001650 ! results in maturation of hypoglossal nerve relationship: BFO:0000050 GO:0021566 ! part of hypoglossal nerve development relationship: RO:0002299 UBERON:0001650 ! results in maturation of hypoglossal nerve [Term] id: GO:0021620 name: hypoglossal nerve formation namespace: biological_process def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN XII biosynthesis" RELATED [] synonym: "CN XII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001650 ! results in formation of hypoglossal nerve relationship: BFO:0000050 GO:0021618 ! part of hypoglossal nerve morphogenesis relationship: RO:0002297 UBERON:0001650 ! results in formation of hypoglossal nerve [Term] id: GO:0021626 name: central nervous system maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system [Term] id: GO:0021635 name: trigeminal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve relationship: BFO:0000050 GO:0021559 ! part of trigeminal nerve development relationship: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve [Term] id: GO:0021636 name: trigeminal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve relationship: BFO:0000050 GO:0021559 ! part of trigeminal nerve development relationship: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve [Term] id: GO:0021638 name: trigeminal nerve formation namespace: biological_process def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN V biosynthesis" RELATED [] synonym: "CN V formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001645 ! results in formation of trigeminal nerve relationship: BFO:0000050 GO:0021636 ! part of trigeminal nerve morphogenesis relationship: RO:0002297 UBERON:0001645 ! results in formation of trigeminal nerve [Term] id: GO:0021643 name: vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001759 ! results in maturation of vagus nerve relationship: BFO:0000050 GO:0021564 ! part of vagus nerve development relationship: RO:0002299 UBERON:0001759 ! results in maturation of vagus nerve [Term] id: GO:0021644 name: vagus nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001759 ! results in morphogenesis of vagus nerve relationship: BFO:0000050 GO:0021564 ! part of vagus nerve development relationship: RO:0002298 UBERON:0001759 ! results in morphogenesis of vagus nerve [Term] id: GO:0021646 name: vagus nerve formation namespace: biological_process def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "CN X biosynthesis" RELATED [] synonym: "CN X formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001759 ! results in formation of vagus nerve relationship: BFO:0000050 GO:0021644 ! part of vagus nerve morphogenesis relationship: RO:0002297 UBERON:0001759 ! results in formation of vagus nerve [Term] id: GO:0021651 name: rhombomere 1 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021593 ! rhombomere morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005499 ! results in morphogenesis of rhombomere 1 relationship: BFO:0000050 GO:0021567 ! part of rhombomere 1 development relationship: RO:0002298 UBERON:0005499 ! results in morphogenesis of rhombomere 1 [Term] id: GO:0021652 name: rhombomere 1 formation namespace: biological_process def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021594 ! rhombomere formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005499 ! results in formation of rhombomere 1 relationship: BFO:0000050 GO:0021651 ! part of rhombomere 1 morphogenesis relationship: RO:0002297 UBERON:0005499 ! results in formation of rhombomere 1 [Term] id: GO:0021654 name: rhombomere boundary formation namespace: biological_process def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0018239 ! results in formation of rhombomere boundary relationship: BFO:0000050 GO:0021594 ! part of rhombomere formation relationship: RO:0002297 UBERON:0018239 ! results in formation of rhombomere boundary [Term] id: GO:0021670 name: lateral ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002285 ! results in development of telencephalic ventricle relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: BFO:0000050 GO:0021591 ! part of ventricular system development relationship: RO:0002296 UBERON:0002285 ! results in development of telencephalic ventricle [Term] id: GO:0021675 name: nerve development namespace: biological_process def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001021 ! results in development of nerve relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0001021 ! results in development of nerve [Term] id: GO:0021678 name: third ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002286 ! results in development of third ventricle relationship: BFO:0000050 GO:0021591 ! part of ventricular system development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0002286 ! results in development of third ventricle [Term] id: GO:0021679 name: cerebellar molecular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002974 ! results in development of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002296 UBERON:0002974 ! results in development of molecular layer of cerebellar cortex [Term] id: GO:0021680 name: cerebellar Purkinje cell layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002979 ! results in development of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002296 UBERON:0002979 ! results in development of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021681 name: cerebellar granular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002956 ! results in development of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002296 UBERON:0002956 ! results in development of granular layer of cerebellar cortex [Term] id: GO:0021682 name: nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001021 ! results in maturation of nerve relationship: BFO:0000050 GO:0021675 ! part of nerve development relationship: RO:0002299 UBERON:0001021 ! results in maturation of nerve [Term] id: GO:0021683 name: cerebellar granular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002956 ! results in morphogenesis of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021681 ! part of cerebellar granular layer development relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002298 UBERON:0002956 ! results in morphogenesis of granular layer of cerebellar cortex [Term] id: GO:0021684 name: cerebellar granular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002956 ! results in formation of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021683 ! part of cerebellar granular layer morphogenesis relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002297 UBERON:0002956 ! results in formation of granular layer of cerebellar cortex [Term] id: GO:0021686 name: cerebellar granular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002956 ! results in maturation of granular layer of cerebellar cortex relationship: BFO:0000050 GO:0021681 ! part of cerebellar granular layer development relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation relationship: RO:0002299 UBERON:0002956 ! results in maturation of granular layer of cerebellar cortex [Term] id: GO:0021687 name: cerebellar molecular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002974 ! results in morphogenesis of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021679 ! part of cerebellar molecular layer development relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002298 UBERON:0002974 ! results in morphogenesis of molecular layer of cerebellar cortex [Term] id: GO:0021688 name: cerebellar molecular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002974 ! results in formation of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021687 ! part of cerebellar molecular layer morphogenesis relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002297 UBERON:0002974 ! results in formation of molecular layer of cerebellar cortex [Term] id: GO:0021690 name: cerebellar molecular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002974 ! results in maturation of molecular layer of cerebellar cortex relationship: BFO:0000050 GO:0021679 ! part of cerebellar molecular layer development relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation relationship: RO:0002299 UBERON:0002974 ! results in maturation of molecular layer of cerebellar cortex [Term] id: GO:0021691 name: cerebellar Purkinje cell layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002979 ! results in maturation of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021680 ! part of cerebellar Purkinje cell layer development relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation relationship: RO:0002299 UBERON:0002979 ! results in maturation of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021692 name: cerebellar Purkinje cell layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002979 ! results in morphogenesis of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021680 ! part of cerebellar Purkinje cell layer development relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002298 UBERON:0002979 ! results in morphogenesis of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021694 name: cerebellar Purkinje cell layer formation namespace: biological_process def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002979 ! results in formation of Purkinje cell layer of cerebellar cortex relationship: BFO:0000050 GO:0021692 ! part of cerebellar Purkinje cell layer morphogenesis relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation relationship: RO:0002297 UBERON:0002979 ! results in formation of Purkinje cell layer of cerebellar cortex [Term] id: GO:0021695 name: cerebellar cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002129 ! results in development of cerebellar cortex relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: RO:0002296 UBERON:0002129 ! results in development of cerebellar cortex [Term] id: GO:0021696 name: cerebellar cortex morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002129 ! results in morphogenesis of cerebellar cortex relationship: BFO:0000050 GO:0021587 ! part of cerebellum morphogenesis relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002298 UBERON:0002129 ! results in morphogenesis of cerebellar cortex [Term] id: GO:0021697 name: cerebellar cortex formation namespace: biological_process def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002129 ! results in formation of cerebellar cortex relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis relationship: RO:0002297 UBERON:0002129 ! results in formation of cerebellar cortex [Term] id: GO:0021699 name: cerebellar cortex maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002129 ! results in maturation of cerebellar cortex relationship: BFO:0000050 GO:0021590 ! part of cerebellum maturation relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development relationship: RO:0002299 UBERON:0002129 ! results in maturation of cerebellar cortex [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] subset: goslim_chembl is_a: GO:0032502 ! developmental process [Term] id: GO:0021701 name: cerebellar Golgi cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000119 ! results in acquisition of features of cerebellar Golgi cell relationship: BFO:0000050 GO:0021684 ! part of cerebellar granular layer formation relationship: RO:0002315 CL:0000119 ! results in acquisition of features of cerebellar Golgi cell [Term] id: GO:0021702 name: cerebellar Purkinje cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000121 ! results in acquisition of features of Purkinje cell relationship: BFO:0000050 GO:0021694 ! part of cerebellar Purkinje cell layer formation relationship: RO:0002315 CL:0000121 ! results in acquisition of features of Purkinje cell [Term] id: GO:0021703 name: locus ceruleus development namespace: biological_process def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "locus caeruleus development" EXACT [] synonym: "locus coeruleus development" EXACT [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus [Term] id: GO:0021704 name: locus ceruleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis relationship: BFO:0000050 GO:0021703 ! part of locus ceruleus development relationship: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus [Term] id: GO:0021705 name: locus ceruleus formation namespace: biological_process def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002148 ! results in formation of locus ceruleus relationship: BFO:0000050 GO:0021584 ! part of pons formation relationship: BFO:0000050 GO:0021704 ! part of locus ceruleus morphogenesis relationship: RO:0002297 UBERON:0002148 ! results in formation of locus ceruleus [Term] id: GO:0021706 name: locus ceruleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus relationship: BFO:0000050 GO:0021586 ! part of pons maturation relationship: BFO:0000050 GO:0021703 ! part of locus ceruleus development relationship: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus [Term] id: GO:0021707 name: cerebellar granule cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:1905962 ! glutamatergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0001031 ! results in acquisition of features of cerebellar granule cell relationship: BFO:0000050 GO:0021684 ! part of cerebellar granular layer formation relationship: RO:0002315 CL:0001031 ! results in acquisition of features of cerebellar granule cell [Term] id: GO:0021710 name: cerebellar stellate cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010010 ! results in acquisition of features of cerebellar stellate cell relationship: BFO:0000050 GO:0021688 ! part of cerebellar molecular layer formation relationship: RO:0002315 CL:0010010 ! results in acquisition of features of cerebellar stellate cell [Term] id: GO:0021718 name: superior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex [Term] id: GO:0021719 name: superior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis relationship: BFO:0000050 GO:0021718 ! part of superior olivary nucleus development relationship: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex [Term] id: GO:0021720 name: superior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007247 ! results in formation of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021584 ! part of pons formation relationship: BFO:0000050 GO:0021719 ! part of superior olivary nucleus morphogenesis relationship: RO:0002297 UBERON:0007247 ! results in formation of nucleus of superior olivary complex [Term] id: GO:0021722 name: superior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] synonym: "superior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex relationship: BFO:0000050 GO:0021586 ! part of pons maturation relationship: BFO:0000050 GO:0021718 ! part of superior olivary nucleus development relationship: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex [Term] id: GO:0021732 name: midbrain-hindbrain boundary maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] synonym: "isthmus maturation" RELATED [] synonym: "MHB maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development relationship: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary [Term] id: GO:0021743 name: hypoglossal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002871 ! results in development of hypoglossal nucleus relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development relationship: RO:0002296 UBERON:0002871 ! results in development of hypoglossal nucleus [Term] id: GO:0021751 name: salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048857 ! neural nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus relationship: BFO:0000050 GO:0021548 ! part of pons development relationship: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus [Term] id: GO:0021753 name: superior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021751 ! salivary nucleus development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus relationship: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus [Term] id: GO:0021756 name: striatum development namespace: biological_process def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "neostriatum development" EXACT [] synonym: "striate nucleus development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002435 ! results in development of striatum relationship: BFO:0000050 GO:0021544 ! part of subpallium development relationship: RO:0002296 UBERON:0002435 ! results in development of striatum [Term] id: GO:0021761 name: limbic system development namespace: biological_process def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000349 ! results in development of limbic system relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002296 UBERON:0000349 ! results in development of limbic system [Term] id: GO:0021773 name: striatal medium spiny neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741] synonym: "striatal MSN differentiation" EXACT [PMID:25804741] is_a: GO:0021879 ! forebrain neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1001474 ! results in acquisition of features of medium spiny neuron relationship: BFO:0000050 GO:0021756 ! part of striatum development relationship: RO:0002315 CL:1001474 ! results in acquisition of features of medium spiny neuron [Term] id: GO:0021782 name: glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000125 ! results in development of glial cell relationship: BFO:0000050 GO:0010001 ! part of glial cell differentiation relationship: RO:0002296 CL:0000125 ! results in development of glial cell [Term] id: GO:0021783 name: preganglionic parasympathetic fiber development namespace: biological_process def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0011930 ! results in development of preganglionic parasympathetic fiber relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: BFO:0000050 GO:0048486 ! part of parasympathetic nervous system development relationship: RO:0002296 UBERON:0011930 ! results in development of preganglionic parasympathetic fiber [Term] id: GO:0021794 name: thalamus development namespace: biological_process def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001897 ! results in development of dorsal plus ventral thalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: RO:0002296 UBERON:0001897 ! results in development of dorsal plus ventral thalamus [Term] id: GO:0021846 name: cell proliferation in forebrain namespace: biological_process def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0001890 ! occurs in forebrain relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: BFO:0000066 UBERON:0001890 ! occurs in forebrain [Term] id: GO:0021848 name: neuroblast division in subpallium namespace: biological_process def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0055057 ! neuroblast division intersection_of: GO:0055057 ! neuroblast division intersection_of: BFO:0000066 UBERON:0000204 ! occurs in ventral part of telencephalon relationship: BFO:0000050 GO:0022012 ! part of subpallium cell proliferation in forebrain relationship: BFO:0000066 UBERON:0000204 ! occurs in ventral part of telencephalon [Term] id: GO:0021854 name: hypothalamus development namespace: biological_process def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001898 ! results in development of hypothalamus relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0021761 ! part of limbic system development relationship: RO:0002296 UBERON:0001898 ! results in development of hypothalamus [Term] id: GO:0021861 name: forebrain radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] synonym: "radial glial cell differentiation in forebrain" EXACT [] is_a: GO:0060019 ! radial glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0013000 ! results in acquisition of features of forebrain radial glial cell relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons relationship: RO:0002315 CL:0013000 ! results in acquisition of features of forebrain radial glial cell [Term] id: GO:0021863 name: forebrain neuroblast differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] is_a: GO:0014016 ! neuroblast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000042 ! results in acquisition of features of forebrain neuroblast relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons relationship: RO:0002315 CL:1000042 ! results in acquisition of features of forebrain neuroblast [Term] id: GO:0021872 name: forebrain generation of neurons namespace: biological_process def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "generation of neurons in forebrain" EXACT [] is_a: GO:0048699 ! generation of neurons relationship: BFO:0000050 GO:0030900 ! part of forebrain development [Term] id: GO:0021879 name: forebrain neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0012001 ! results in acquisition of features of neuron of the forebrain relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons relationship: RO:0002315 CL:0012001 ! results in acquisition of features of neuron of the forebrain [Term] id: GO:0021884 name: forebrain neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021954 ! central nervous system neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0012001 ! results in development of neuron of the forebrain relationship: BFO:0000050 GO:0021879 ! part of forebrain neuron differentiation relationship: RO:0002296 CL:0012001 ! results in development of neuron of the forebrain [Term] id: GO:0021885 name: forebrain cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0016477 ! cell migration relationship: BFO:0000050 GO:0030900 ! part of forebrain development [Term] id: GO:0021896 name: forebrain astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] is_a: GO:0048708 ! astrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0012000 ! results in acquisition of features of astrocyte of the forebrain relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: RO:0002315 CL:0012000 ! results in acquisition of features of astrocyte of the forebrain [Term] id: GO:0021897 name: forebrain astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0014002 ! astrocyte development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0012000 ! results in development of astrocyte of the forebrain relationship: BFO:0000050 GO:0021896 ! part of forebrain astrocyte differentiation relationship: RO:0002296 CL:0012000 ! results in development of astrocyte of the forebrain [Term] id: GO:0021903 name: rostrocaudal neural tube patterning namespace: biological_process def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: BFO:0000050 GO:0021532 ! part of neural tube patterning [Term] id: GO:0021905 name: forebrain-midbrain boundary formation namespace: biological_process def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005075 ! results in formation of forebrain-midbrain boundary relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002297 UBERON:0005075 ! results in formation of forebrain-midbrain boundary [Term] id: GO:0021906 name: hindbrain-spinal cord boundary formation namespace: biological_process def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005076 ! results in formation of hindbrain-spinal cord boundary relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002297 UBERON:0005076 ! results in formation of hindbrain-spinal cord boundary [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001049 ! results in development of neural tube relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002296 UBERON:0001049 ! results in development of neural tube [Term] id: GO:0021953 name: central nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron [Term] id: GO:0021954 name: central nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048666 ! neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000029 ! results in development of central nervous system neuron relationship: BFO:0000050 GO:0021953 ! part of central nervous system neuron differentiation relationship: RO:0002296 CL:2000029 ! results in development of central nervous system neuron [Term] id: GO:0021982 name: pineal gland development namespace: biological_process def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "epiphysis development" EXACT [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001905 ! results in development of pineal body relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0001905 ! results in development of pineal body [Term] id: GO:0021983 name: pituitary gland development namespace: biological_process def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "hypophysis development" RELATED [GOC:dph] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000007 ! results in development of pituitary gland relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0035270 ! part of endocrine system development relationship: RO:0002296 UBERON:0000007 ! results in development of pituitary gland [Term] id: GO:0021984 name: adenohypophysis development namespace: biological_process def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis development" EXACT [] synonym: "anterior pituitary development" EXACT [] synonym: "anterior pituitary gland development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002196 ! results in development of adenohypophysis relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development relationship: RO:0002296 UBERON:0002196 ! results in development of adenohypophysis [Term] id: GO:0021985 name: neurohypophysis development namespace: biological_process def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis development" EXACT [] synonym: "posterior pituitary development" EXACT [] synonym: "posterior pituitary gland development" EXACT [] is_a: GO:0048732 ! gland development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002198 ! results in development of neurohypophysis relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development relationship: RO:0002296 UBERON:0002198 ! results in development of neurohypophysis [Term] id: GO:0021990 name: neural plate formation namespace: biological_process def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003075 ! results in formation of neural plate relationship: BFO:0000050 GO:0001839 ! part of neural plate morphogenesis relationship: RO:0002297 UBERON:0003075 ! results in formation of neural plate [Term] id: GO:0021999 name: neural plate anterior/posterior regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: BFO:0000050 GO:0007399 ! part of nervous system development [Term] id: GO:0022009 name: central nervous system vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system [Term] id: GO:0022010 name: central nervous system myelination namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "myelination in central nervous system" EXACT [] is_a: GO:0032291 ! axon ensheathment in central nervous system is_a: GO:0042552 ! myelination intersection_of: GO:0042552 ! myelination intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: BFO:0000050 GO:0014003 ! part of oligodendrocyte development [Term] id: GO:0022011 name: myelination in peripheral nervous system namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "peripheral nervous system myelination" EXACT [] is_a: GO:0032292 ! peripheral nervous system axon ensheathment is_a: GO:0042552 ! myelination intersection_of: GO:0042552 ! myelination intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system relationship: BFO:0000050 GO:0014044 ! part of Schwann cell development [Term] id: GO:0022012 name: subpallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021846 ! cell proliferation in forebrain relationship: BFO:0000050 GO:0021544 ! part of subpallium development [Term] id: GO:0022029 name: telencephalon cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0021885 ! forebrain cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon relationship: BFO:0000050 GO:0021537 ! part of telencephalon development relationship: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon [Term] id: GO:0022030 name: telencephalon glial cell migration namespace: biological_process def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0008347 ! glial cell migration is_a: GO:0022029 ! telencephalon cell migration intersection_of: GO:0008347 ! glial cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon [Term] id: GO:0022031 name: telencephalon astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration is_a: GO:0043615 ! astrocyte cell migration intersection_of: GO:0043615 ! astrocyte cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon [Term] id: GO:0022032 name: telencephalon oligodendrocyte cell migration namespace: biological_process def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon intersection_of: RO:0004009 CL:0000128 ! has primary input oligodendrocyte relationship: RO:0004009 CL:0000128 ! has primary input oligodendrocyte [Term] id: GO:0022033 name: telencephalon microglial cell migration namespace: biological_process def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon intersection_of: RO:0004009 CL:0000129 ! has primary input microglial cell relationship: RO:0004009 CL:0000129 ! has primary input microglial cell [Term] id: GO:0022035 name: rhombomere cell migration namespace: biological_process def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700] is_a: GO:0021535 ! cell migration in hindbrain intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere relationship: BFO:0000050 GO:0021546 ! part of rhombomere development relationship: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere [Term] id: GO:0022037 name: metencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001895 ! results in development of metencephalon relationship: BFO:0000050 GO:0030902 ! part of hindbrain development relationship: RO:0002296 UBERON:0001895 ! results in development of metencephalon [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate subset: goslim_euk_cellular_processes_ribbon is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0007049 ! part of cell cycle relationship: BFO:0000050 GO:0007049 ! part of cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098609 ! regulates cell-cell adhesion relationship: RO:0002211 GO:0098609 ! regulates cell-cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "down regulation of cell-cell adhesion" EXACT [] synonym: "down-regulation of cell-cell adhesion" EXACT [] synonym: "downregulation of cell-cell adhesion" EXACT [] synonym: "inhibition of cell-cell adhesion" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098609 ! negatively regulates cell-cell adhesion relationship: RO:0002212 GO:0098609 ! negatively regulates cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "activation of cell-cell adhesion" NARROW [] synonym: "stimulation of cell-cell adhesion" NARROW [] synonym: "up regulation of cell-cell adhesion" EXACT [] synonym: "up-regulation of cell-cell adhesion" EXACT [] synonym: "upregulation of cell-cell adhesion" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098609 ! positively regulates cell-cell adhesion relationship: RO:0002213 GO:0098609 ! positively regulates cell-cell adhesion [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002590 GO:0005575 ! results in disassembly of cellular_component disjoint_from: GO:0022607 ! cellular component assembly relationship: RO:0002590 GO:0005575 ! results in disassembly of cellular_component [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "single organism reproductive process" RELATED [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0022600 name: digestive system process namespace: biological_process def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] subset: goslim_generic is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: BFO:0000050 GO:0007586 ! part of digestion relationship: BFO:0000050 GO:0007586 ! part of digestion [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis relationship: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000902 ! regulates cell morphogenesis relationship: RO:0002211 GO:0000902 ! regulates cell morphogenesis [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0005575 ! results in assembly of cellular_component relationship: BFO:0000050 GO:0044085 ! part of cellular component biogenesis relationship: RO:0002588 GO:0005575 ! results in assembly of cellular_component [Term] id: GO:0022612 name: gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland relationship: BFO:0000050 GO:0048732 ! part of gland development relationship: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0022617 name: extracellular matrix disassembly namespace: biological_process def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] xref: Reactome:R-HSA-1474228 "Degradation of the extracellular matrix" is_a: GO:0022411 ! cellular component disassembly is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix relationship: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix [Term] id: GO:0022618 name: protein-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl synonym: "ribonucleoprotein complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex relationship: BFO:0000050 GO:0022613 ! part of ribonucleoprotein complex biogenesis relationship: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex [Term] id: GO:0022626 name: cytosolic ribosome namespace: cellular_component def: "A ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0005829 ! part of cytosol relationship: BFO:0000050 GO:0005829 ! part of cytosol [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_drosophila subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" RELATED [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" xref: Reactome:R-HSA-8954513 "NAASP translocates from mitochondrial matrix to cytosol" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: BFO:0000050 GO:0055085 ! part of transmembrane transport relationship: RO:0002342 GO:0016020 ! results in transport across membrane [Term] id: GO:0022884 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule relationship: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] subset: gocheck_obsoletion_candidate is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0034762 ! regulation of transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity relationship: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000050 GO:0010468 ! part of regulation of gene expression relationship: BFO:0000050 GO:0010468 ! part of regulation of gene expression creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023023 name: MHC protein complex binding namespace: molecular_function def: "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0042611 ! has primary input MHC protein complex relationship: RO:0004009 GO:0042611 ! has primary input MHC protein complex creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023026 name: MHC class II protein complex binding namespace: molecular_function def: "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0042613 ! has primary input MHC class II protein complex relationship: RO:0004009 GO:0042613 ! has primary input MHC class II protein complex creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0023052 ! regulates signaling relationship: RO:0002211 GO:0023052 ! regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 alt_id: GO:0044700 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0050789 ! regulation of biological process disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0023052 ! positively regulates signaling relationship: RO:0002213 GO:0023052 ! positively regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0023052 ! negatively regulates signaling relationship: RO:0002212 GO:0023052 ! negatively regulates signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] synonym: "signal secretion" EXACT [GOC:bf] is_a: GO:0032940 ! secretion by cell intersection_of: GO:0032940 ! secretion by cell intersection_of: BFO:0000050 GO:0007267 ! part of cell-cell signaling relationship: BFO:0000050 GO:0007267 ! part of cell-cell signaling creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030016 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] xref: Wikipedia:Myofibril is_a: GO:0043292 ! contractile muscle fiber intersection_of: GO:0043292 ! contractile muscle fiber intersection_of: BFO:0000050 CL:0000737 ! part of striated muscle cell relationship: BFO:0000050 CL:0000737 ! part of striated muscle cell [Term] id: GO:0030017 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: Wikipedia:Sarcomere is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0030016 ! part of myofibril [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002608 GO:0005884 ! process has causal agent actin filament relationship: RO:0002608 GO:0005884 ! process has causal agent actin filament [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917] subset: goslim_prokaryote synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042995 ! results in organization of cell projection relationship: RO:0002592 GO:0042995 ! results in organization of cell projection [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042995 ! results in assembly of cell projection relationship: RO:0002588 GO:0042995 ! results in assembly of cell projection [Term] id: GO:0030033 name: microvillus assembly namespace: biological_process def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] synonym: "microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005902 ! results in assembly of microvillus relationship: RO:0002588 GO:0005902 ! results in assembly of microvillus [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe synonym: "actin cytoskeleton organisation" EXACT [] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton relationship: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030050 name: vesicle transport along actin filament namespace: biological_process def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264] subset: goslim_agr subset: goslim_drosophila subset: goslim_flybase_ribbon xref: Wikipedia:Cell_junction is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0030072 name: peptide hormone secretion namespace: biological_process def: "The regulated release of a peptide hormone from a cell." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:25905 ! has primary input relationship: RO:0004009 CHEBI:25905 ! has primary input [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000988 ! results in development of hematopoietic cell relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 CL:0000988 ! results in development of hematopoietic cell [Term] id: GO:0030098 name: lymphocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "lymphocyte cell differentiation" EXACT [] synonym: "lymphocyte development" RELATED [GOC:add] synonym: "lymphocytic blood cell differentiation" EXACT [] is_a: GO:0046649 ! lymphocyte activation is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000542 ! results in acquisition of features of lymphocyte relationship: RO:0002315 CL:0000542 ! results in acquisition of features of lymphocyte [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell [Term] id: GO:0030100 name: regulation of endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006897 ! regulates endocytosis relationship: RO:0002211 GO:0006897 ! regulates endocytosis [Term] id: GO:0030103 name: vasopressin secretion namespace: biological_process def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:9937 ! has primary input relationship: RO:0004009 CHEBI:9937 ! has primary input [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0030150 name: protein import into mitochondrial matrix namespace: biological_process def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] synonym: "mitochondrial matrix protein import" EXACT [] synonym: "mitochondrial translocation" BROAD [] synonym: "protein transport into mitochondrial matrix" EXACT [] is_a: GO:0071806 ! protein transmembrane transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_plant_ribbon xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0048869 ! cellular developmental process intersection_of: RO:0002315 CL:0000000 ! results in acquisition of features of cell relationship: RO:0002315 CL:0000000 ! results in acquisition of features of cell [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007155 ! regulates cell adhesion relationship: RO:0002211 GO:0007155 ! regulates cell adhesion [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006508 ! regulates proteolysis relationship: RO:0002211 GO:0006508 ! regulates proteolysis [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_candida subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolic process" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] synonym: "multicellular organismal protein catabolic process" NARROW [] synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000540 ! results in acquisition of features of neuron relationship: BFO:0000050 GO:0048699 ! part of generation of neurons relationship: RO:0002315 CL:0000540 ! results in acquisition of features of neuron [Term] id: GO:0030186 name: melatonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin metabolism" EXACT [] is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16796 ! has primary input or output relationship: RO:0004007 CHEBI:16796 ! has primary input or output [Term] id: GO:0030187 name: melatonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin anabolism" EXACT [] synonym: "melatonin biosynthesis" EXACT [] synonym: "melatonin formation" EXACT [] synonym: "melatonin synthesis" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16796 ! has primary output relationship: RO:0004008 CHEBI:16796 ! has primary output [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] xref: Reactome:R-HSA-1474244 "Extracellular matrix organization" is_a: GO:0043062 ! extracellular structure organization is_a: GO:0045229 ! external encapsulating structure organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031012 ! results in organization of extracellular matrix relationship: RO:0002592 GO:0031012 ! results in organization of extracellular matrix [Term] id: GO:0030199 name: collagen fibril organization namespace: biological_process def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] synonym: "collagen fibril organisation" EXACT [] synonym: "fibrillar collagen organization" EXACT [GOC:mah] xref: Reactome:R-HSA-1474290 "Collagen formation" xref: Reactome:R-HSA-2214320 "Anchoring fibril formation" xref: Reactome:R-HSA-2243919 "Crosslinking of collagen fibrils" is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098643 ! results in organization of fibrillar collagen relationship: RO:0002592 GO:0098643 ! results in organization of fibrillar collagen [Term] id: GO:0030203 name: glycosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384] synonym: "glycosaminoglycan metabolism" EXACT [] xref: Reactome:R-HSA-1630316 "Glycosaminoglycan metabolism" is_a: GO:0006022 ! aminoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18085 ! has primary input or output relationship: RO:0004007 CHEBI:18085 ! has primary input or output [Term] id: GO:0030212 name: hyaluronan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan metabolism" EXACT [] xref: Reactome:R-HSA-2142845 "Hyaluronan metabolism" is_a: GO:0030203 ! glycosaminoglycan metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16336 ! has primary input or output relationship: RO:0004007 CHEBI:16336 ! has primary input or output [Term] id: GO:0030213 name: hyaluronan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan anabolism" EXACT [] synonym: "hyaluronan biosynthesis" EXACT [] synonym: "hyaluronan formation" EXACT [] synonym: "hyaluronan synthesis" EXACT [] xref: Reactome:R-HSA-2142850 "Hyaluronan biosynthesis and export" is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030212 ! hyaluronan metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16336 ! has primary output relationship: RO:0004008 CHEBI:16336 ! has primary output [Term] id: GO:0030214 name: hyaluronan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932] synonym: "hyaluronan breakdown" EXACT [] synonym: "hyaluronan catabolism" EXACT [] synonym: "hyaluronan degradation" EXACT [] xref: MetaCyc:PWY-7645 xref: Reactome:R-HSA-2160916 "Hyaluronan uptake and degradation" is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030212 ! hyaluronan metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16336 ! has primary input relationship: RO:0004009 CHEBI:16336 ! has primary input [Term] id: GO:0030217 name: T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah] comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development" RELATED [GOC:add] synonym: "T lymphocyte differentiation" EXACT [] synonym: "T-cell differentiation" EXACT [] synonym: "T-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000084 ! results in acquisition of features of T cell relationship: RO:0002315 CL:0000084 ! results in acquisition of features of T cell [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte relationship: BFO:0000050 GO:0034101 ! part of erythrocyte homeostasis relationship: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte [Term] id: GO:0030219 name: megakaryocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] synonym: "megakaryocyte cell differentiation" EXACT [] is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte relationship: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte [Term] id: GO:0030224 name: monocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] synonym: "monocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000576 ! results in acquisition of features of monocyte relationship: RO:0002315 CL:0000576 ! results in acquisition of features of monocyte [Term] id: GO:0030225 name: macrophage differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] synonym: "macrophage cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000235 ! results in acquisition of features of macrophage relationship: RO:0002315 CL:0000235 ! results in acquisition of features of macrophage [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0097435 ! supramolecular fiber organization is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030016 ! results in assembly of myofibril relationship: BFO:0000050 GO:0055002 ! part of striated muscle cell development relationship: RO:0002588 GO:0030016 ! results in assembly of myofibril [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0030247 name: polysaccharide binding namespace: molecular_function alt_id: GO:0002506 def: "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah] synonym: "polysaccharide assembly with MHC class II protein complex" NARROW [] is_a: GO:0030246 ! carbohydrate binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0030252 name: growth hormone secretion namespace: biological_process def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] synonym: "somatotropin secretion" EXACT [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0030262 name: apoptotic nuclear changes namespace: biological_process def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] synonym: "apoptotic nuclear change" NARROW [] is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes [Term] id: GO:0030264 name: nuclear fragmentation involved in apoptotic nuclear change namespace: biological_process def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976] synonym: "apoptotic nuclear fragmentation" EXACT [] synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "nucleus fragmentation" EXACT [] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes [Term] id: GO:0030278 name: regulation of ossification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "regulation of bone biosynthesis" EXACT [] synonym: "regulation of bone formation" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001503 ! regulates ossification relationship: RO:0002211 GO:0001503 ! regulates ossification [Term] id: GO:0030279 name: negative regulation of ossification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "down regulation of ossification" EXACT [] synonym: "down-regulation of ossification" EXACT [] synonym: "downregulation of ossification" EXACT [] synonym: "inhibition of ossification" NARROW [] synonym: "negative regulation of bone biosynthesis" EXACT [] synonym: "negative regulation of bone formation" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001503 ! negatively regulates ossification relationship: RO:0002212 GO:0001503 ! negatively regulates ossification [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016049 ! positively regulates cell growth relationship: RO:0002213 GO:0016049 ! positively regulates cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016049 ! negatively regulates cell growth relationship: RO:0002212 GO:0016049 ! negatively regulates cell growth [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0030316 name: osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] synonym: "osteoclast cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000092 ! results in acquisition of features of osteoclast relationship: RO:0002315 CL:0000092 ! results in acquisition of features of osteoclast [Term] id: GO:0030323 name: respiratory tube development namespace: biological_process def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000117 ! results in development of respiratory tube relationship: RO:0002296 UBERON:0000117 ! results in development of respiratory tube [Term] id: GO:0030324 name: lung development namespace: biological_process def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002048 ! results in development of lung relationship: BFO:0000050 GO:0030323 ! part of respiratory tube development relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002296 UBERON:0002048 ! results in development of lung [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016477 ! regulates cell migration relationship: RO:0002211 GO:0016477 ! regulates cell migration [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016477 ! positively regulates cell migration relationship: RO:0002213 GO:0016477 ! positively regulates cell migration [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016477 ! negatively regulates cell migration relationship: RO:0002212 GO:0016477 ! negatively regulates cell migration [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0016020 ! results in disassembly of membrane relationship: RO:0002590 GO:0016020 ! results in disassembly of membrane [Term] id: GO:0030424 name: axon namespace: cellular_component def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1770195789 xref: Wikipedia:Axon is_a: GO:0043005 ! neuron projection [Term] id: GO:0030425 name: dendrite namespace: cellular_component def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1211023249 xref: Wikipedia:Dendrite is_a: GO:0043005 ! neuron projection relationship: BFO:0000050 GO:0097447 ! part of dendritic tree [Term] id: GO:0030428 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0030436 name: asexual sporulation namespace: biological_process def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886] synonym: "asexual reproductive sporulation" EXACT [] synonym: "asexual spore formation" EXACT [] synonym: "mitotic spore formation" EXACT [] synonym: "mitotic sporulation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0019954 ! asexual reproduction is_a: GO:0043934 ! sporulation [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_candida is_a: GO:0040007 ! growth [Term] id: GO:0030448 name: hyphal growth namespace: biological_process alt_id: GO:0075061 def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] subset: goslim_candida synonym: "formation of symbiont invasive hypha in host" EXACT [] synonym: "formation of symbiont invasive hypha within host" EXACT [] synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT [] synonym: "invasive hyphal growth" EXACT [] synonym: "symbiont invasive hypha formation within host" EXACT [] is_a: GO:0030447 ! filamentous growth [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule intersection_of: GO:0007097 ! nuclear migration intersection_of: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton relationship: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton [Term] id: GO:0030485 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] is_a: GO:0043292 ! contractile muscle fiber intersection_of: GO:0043292 ! contractile muscle fiber intersection_of: BFO:0000050 CL:0000192 ! part of smooth muscle cell relationship: BFO:0000050 CL:0000192 ! part of smooth muscle cell [Term] id: GO:0030574 name: collagen catabolic process namespace: biological_process def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] synonym: "collagen breakdown" EXACT [] synonym: "collagen catabolism" EXACT [] synonym: "collagen degradation" EXACT [] xref: Reactome:R-HSA-1442490 "Collagen degradation" is_a: GO:0009056 ! catabolic process is_a: GO:0032963 ! collagen metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer [Term] id: GO:0030594 name: neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity' is_a: GO:0038023 ! signaling receptor activity relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0030595 name: leukocyte chemotaxis namespace: biological_process def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] synonym: "immune cell chemotaxis" EXACT [] synonym: "leucocyte chemotaxis" EXACT [] is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030133 ! bounding layer of transport vesicle relationship: RO:0002007 GO:0030133 ! bounding layer of transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0031410 ! part of cytoplasmic vesicle relationship: BFO:0000050 GO:0031410 ! part of cytoplasmic vesicle [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005798 ! bounding layer of Golgi-associated vesicle relationship: RO:0002007 GO:0005798 ! bounding layer of Golgi-associated vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030141 ! bounding layer of secretory granule relationship: RO:0002007 GO:0030141 ! bounding layer of secretory granule [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_drosophila is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber relationship: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber [Term] id: GO:0030720 name: oocyte localization involved in germarium-derived egg chamber formation namespace: biological_process def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] synonym: "oocyte localization during oogenesis" RELATED [] synonym: "oocyte positioning during oogenesis" NARROW [] synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] synonym: "oogenesis, oocyte localization" EXACT [] is_a: GO:0051674 ! localization of cell intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CL:0000023 ! has primary input oocyte relationship: BFO:0000050 GO:0007293 ! part of germarium-derived egg chamber formation relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta relationship: RO:0004009 CL:0000023 ! has primary input oocyte [Term] id: GO:0030849 name: autosome namespace: cellular_component def: "Any chromosome other than a sex chromosome." [GOC:mah] comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. xref: Wikipedia:Autosome is_a: GO:0005694 ! chromosome [Term] id: GO:0030851 name: granulocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] synonym: "granulocyte cell differentiation" EXACT [] xref: Reactome:R-HSA-9616222 "Transcriptional regulation of granulopoiesis" is_a: GO:0002573 ! myeloid leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000094 ! results in acquisition of features of granulocyte relationship: RO:0002315 CL:0000094 ! results in acquisition of features of granulocyte [Term] id: GO:0030852 name: regulation of granulocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030851 ! regulates granulocyte differentiation relationship: RO:0002211 GO:0030851 ! regulates granulocyte differentiation [Term] id: GO:0030853 name: negative regulation of granulocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "down regulation of granulocyte differentiation" EXACT [] synonym: "down-regulation of granulocyte differentiation" EXACT [] synonym: "downregulation of granulocyte differentiation" EXACT [] synonym: "inhibition of granulocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030851 ! negatively regulates granulocyte differentiation relationship: RO:0002212 GO:0030851 ! negatively regulates granulocyte differentiation [Term] id: GO:0030854 name: positive regulation of granulocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "activation of granulocyte differentiation" NARROW [] synonym: "stimulation of granulocyte differentiation" NARROW [] synonym: "up regulation of granulocyte differentiation" EXACT [] synonym: "up-regulation of granulocyte differentiation" EXACT [] synonym: "upregulation of granulocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030851 ! positively regulates granulocyte differentiation relationship: RO:0002213 GO:0030851 ! positively regulates granulocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell relationship: BFO:0000050 GO:0060429 ! part of epithelium development relationship: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation relationship: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation relationship: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation relationship: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation [Term] id: GO:0030885 name: regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001773 ! regulates myeloid dendritic cell activation relationship: RO:0002211 GO:0001773 ! regulates myeloid dendritic cell activation [Term] id: GO:0030886 name: negative regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] synonym: "down regulation of myeloid dendritic cell activation" EXACT [] synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] synonym: "downregulation of myeloid dendritic cell activation" EXACT [] synonym: "inhibition of myeloid dendritic cell activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001773 ! negatively regulates myeloid dendritic cell activation relationship: RO:0002212 GO:0001773 ! negatively regulates myeloid dendritic cell activation [Term] id: GO:0030887 name: positive regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] synonym: "activation of myeloid dendritic cell activation" NARROW [] synonym: "stimulation of myeloid dendritic cell activation" NARROW [] synonym: "up regulation of myeloid dendritic cell activation" EXACT [] synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] synonym: "upregulation of myeloid dendritic cell activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001773 ! positively regulates myeloid dendritic cell activation relationship: RO:0002213 GO:0001773 ! positively regulates myeloid dendritic cell activation [Term] id: GO:0030900 name: forebrain development namespace: biological_process def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [PMID:4975589, PMID:4992177] synonym: "prosencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001890 ! results in development of forebrain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0001890 ! results in development of forebrain [Term] id: GO:0030901 name: midbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177] synonym: "mesencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001891 ! results in development of midbrain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001891 ! results in development of midbrain [Term] id: GO:0030902 name: hindbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [PMID:4975589, PMID:4992177] synonym: "rhombencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002028 ! results in development of hindbrain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002296 UBERON:0002028 ! results in development of hindbrain [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002328 ! results in development of notochord relationship: RO:0002296 UBERON:0002328 ! results in development of notochord [Term] id: GO:0030917 name: midbrain-hindbrain boundary development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] synonym: "isthmic organizer development" EXACT [] synonym: "isthmomesencephalic boundary development" EXACT [] synonym: "isthmus development" EXACT [] synonym: "MHB development" EXACT [] synonym: "midbrain-hindbrain orgainizer development" EXACT [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning relationship: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary [Term] id: GO:0030936 name: transmembrane collagen trimer namespace: cellular_component def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976] synonym: "MACIT" EXACT [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane [Term] id: GO:0030951 name: establishment or maintenance of microtubule cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] synonym: "cytoskeleton polarization" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: RO:0002216 GO:0035735 ! capable of part of intraciliary transport involved in cilium assembly [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, PMID:21123617, PMID:28089324, PMID:33605520] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0030312 ! external encapsulating structure disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle disjoint_from: GO:0044423 ! virion component [Term] id: GO:0031022 name: nuclear migration along microfilament namespace: biological_process def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] synonym: "nuclear migration, microfilament-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport intersection_of: GO:0007097 ! nuclear migration intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0042641 ! results in organization of actomyosin relationship: RO:0002592 GO:0042641 ! results in organization of actomyosin [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] xref: NIF_Subcellular:sao772007592 is_a: GO:0030141 ! secretory granule [Term] id: GO:0031076 name: embryonic camera-type eye development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "embryonic eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle relationship: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] synonym: "microtubule dynamics" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031110 name: regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization relationship: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization [Term] id: GO:0031111 name: negative regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization relationship: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization [Term] id: GO:0031112 name: positive regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "activation of microtubule polymerization or depolymerization" NARROW [] synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization relationship: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization [Term] id: GO:0031113 name: regulation of microtubule polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046785 ! regulates microtubule polymerization relationship: RO:0002211 GO:0046785 ! regulates microtubule polymerization [Term] id: GO:0031114 name: regulation of microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "regulation of microtubule disassembly" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007019 ! regulates microtubule depolymerization relationship: RO:0002211 GO:0007019 ! regulates microtubule depolymerization [Term] id: GO:0031115 name: negative regulation of microtubule polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization" EXACT [] synonym: "down-regulation of microtubule polymerization" EXACT [] synonym: "downregulation of microtubule polymerization" EXACT [] synonym: "inhibition of microtubule polymerization" NARROW [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization relationship: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization [Term] id: GO:0031116 name: positive regulation of microtubule polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "activation of microtubule polymerization" NARROW [] synonym: "stimulation of microtubule polymerization" NARROW [] synonym: "up regulation of microtubule polymerization" EXACT [] synonym: "up-regulation of microtubule polymerization" EXACT [] synonym: "upregulation of microtubule polymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization relationship: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization [Term] id: GO:0031117 name: positive regulation of microtubule depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "activation of microtubule depolymerization" NARROW [] synonym: "microtubule destabilization" EXACT [] synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of microtubule disassembly" EXACT [] synonym: "stimulation of microtubule depolymerization" NARROW [] synonym: "up regulation of microtubule depolymerization" EXACT [] synonym: "up-regulation of microtubule depolymerization" EXACT [] synonym: "upregulation of microtubule depolymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization relationship: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule relationship: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule [Term] id: GO:0031128 name: developmental induction namespace: biological_process def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535] is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: BFO:0000051 GO:0045168 ! has part cell-cell signaling involved in cell fate commitment relationship: BFO:0000051 GO:0045168 ! has part cell-cell signaling involved in cell fate commitment [Term] id: GO:0031143 name: pseudopodium namespace: cellular_component def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732] subset: goslim_pir synonym: "axopodium" NARROW [] synonym: "lobopodium" NARROW [] synonym: "pseudopod" EXACT [] synonym: "pseudopodial protrusion" EXACT [] synonym: "reticulopodium" NARROW [] xref: Wikipedia:Pseudopod is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: BFO:0000050 GO:0048666 ! part of neuron development relationship: BFO:0000050 GO:0048666 ! part of neuron development [Term] id: GO:0031252 name: cell leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] synonym: "leading edge of cell" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0031253 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0120025 ! bounding layer of plasma membrane bounded cell projection relationship: RO:0002007 GO:0120025 ! bounding layer of plasma membrane bounded cell projection [Term] id: GO:0031256 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005886 ! part of plasma membrane relationship: BFO:0000050 GO:0031252 ! part of cell leading edge [Term] id: GO:0031268 name: pseudopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] synonym: "pseudopodium organisation" EXACT [] synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031143 ! results in organization of pseudopodium relationship: RO:0002592 GO:0031143 ! results in organization of pseudopodium [Term] id: GO:0031269 name: pseudopodium assembly namespace: biological_process def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "pseudopodium extension" EXACT [] synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031268 ! pseudopodium organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031143 ! results in assembly of pseudopodium relationship: RO:0002588 GO:0031143 ! results in assembly of pseudopodium [Term] id: GO:0031270 name: pseudopodium retraction namespace: biological_process def: "The myosin-based contraction and retraction of a pseudopodium." [GOC:pg] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0031268 ! pseudopodium organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031143 ! results in disassembly of pseudopodium relationship: RO:0002590 GO:0031143 ! results in disassembly of pseudopodium [Term] id: GO:0031272 name: regulation of pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "regulation of pseudopodium formation" RELATED [] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031269 ! regulates pseudopodium assembly relationship: RO:0002211 GO:0031269 ! regulates pseudopodium assembly [Term] id: GO:0031273 name: negative regulation of pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "down regulation of pseudopodium formation" RELATED [] synonym: "down-regulation of pseudopodium formation" RELATED [] synonym: "downregulation of pseudopodium formation" RELATED [] synonym: "inhibition of pseudopodium formation" NARROW [] synonym: "negative regulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031269 ! negatively regulates pseudopodium assembly relationship: RO:0002212 GO:0031269 ! negatively regulates pseudopodium assembly [Term] id: GO:0031274 name: positive regulation of pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "activation of pseudopodium formation" NARROW [] synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph] synonym: "stimulation of pseudopodium formation" NARROW [] synonym: "up regulation of pseudopodium formation" RELATED [] synonym: "up-regulation of pseudopodium formation" RELATED [] synonym: "upregulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031269 ! positively regulates pseudopodium assembly relationship: RO:0002213 GO:0031269 ! positively regulates pseudopodium assembly [Term] id: GO:0031333 name: negative regulation of protein-containing complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] synonym: "negative regulation of protein complex assembly" RELATED [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly relationship: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein-containing complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "positive regulation of protein complex assembly" RELATED [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly relationship: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006906 ! regulates vesicle fusion relationship: RO:0002211 GO:0006906 ! regulates vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion relationship: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006906 ! positively regulates vesicle fusion relationship: RO:0002213 GO:0006906 ! positively regulates vesicle fusion [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030030 ! regulates cell projection organization relationship: RO:0002211 GO:0030030 ! regulates cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030030 ! negatively regulates cell projection organization relationship: RO:0002212 GO:0030030 ! negatively regulates cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030030 ! positively regulates cell projection organization relationship: RO:0002213 GO:0030030 ! positively regulates cell projection organization [Term] id: GO:0031347 name: regulation of defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006952 ! regulates defense response relationship: RO:0002211 GO:0006952 ! regulates defense response [Term] id: GO:0031348 name: negative regulation of defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] synonym: "down regulation of defense response" EXACT [] synonym: "down-regulation of defense response" EXACT [] synonym: "downregulation of defense response" EXACT [] synonym: "inhibition of defense response" NARROW [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006952 ! negatively regulates defense response relationship: RO:0002212 GO:0006952 ! negatively regulates defense response [Term] id: GO:0031349 name: positive regulation of defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] synonym: "activation of defense response" NARROW [] synonym: "stimulation of defense response" NARROW [] synonym: "up regulation of defense response" EXACT [] synonym: "up-regulation of defense response" EXACT [] synonym: "upregulation of defense response" EXACT [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006952 ! positively regulates defense response relationship: RO:0002213 GO:0006952 ! positively regulates defense response [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036211 ! regulates protein modification process relationship: RO:0002211 GO:0036211 ! regulates protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036211 ! negatively regulates protein modification process relationship: RO:0002212 GO:0036211 ! negatively regulates protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036211 ! positively regulates protein modification process relationship: RO:0002213 GO:0036211 ! positively regulates protein modification process [Term] id: GO:0031406 name: carboxylic acid binding namespace: molecular_function def: "Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732] subset: goslim_pir is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0097708 ! intracellular vesicle intersection_of: GO:0031982 ! vesicle intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process alt_id: GO:0034629 def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "cellular protein complex localisation" RELATED [GOC:mah] synonym: "cellular protein complex localization" RELATED [] synonym: "cellular protein-containing complex localization" RELATED [] synonym: "establishment and maintenance of cellular protein complex localization" RELATED [] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex [Term] id: GO:0031514 name: motile cilium namespace: cellular_component def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] synonym: "microtubule-based flagellum" RELATED [] synonym: "motile cilia" EXACT [] synonym: "motile primary cilia" RELATED [] synonym: "motile primary cilium" RELATED [] synonym: "motile secondary cilium" RELATED [] synonym: "nodal cilium" RELATED [] is_a: GO:0005929 ! cilium intersection_of: GO:0005929 ! cilium intersection_of: RO:0002215 GO:0003341 ! capable of cilium movement relationship: RO:0002215 GO:0003341 ! capable of cilium movement [Term] id: GO:0031594 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512] synonym: "NMJ" RELATED [GOC:ha] xref: NIF_Subcellular:sao1124888485 xref: Wikipedia:Neuromuscular_junction is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0000187 ! overlaps muscle cell relationship: RO:0002131 CL:0000100 ! overlaps motor neuron relationship: RO:0002131 CL:0000187 ! overlaps muscle cell [Term] id: GO:0031641 name: regulation of myelination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042552 ! regulates myelination relationship: RO:0002211 GO:0042552 ! regulates myelination [Term] id: GO:0031642 name: negative regulation of myelination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "down regulation of myelination" EXACT [] synonym: "down-regulation of myelination" EXACT [] synonym: "downregulation of myelination" EXACT [] synonym: "inhibition of myelination" NARROW [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042552 ! negatively regulates myelination relationship: RO:0002212 GO:0042552 ! negatively regulates myelination [Term] id: GO:0031643 name: positive regulation of myelination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "activation of myelination" NARROW [] synonym: "stimulation of myelination" NARROW [] synonym: "up regulation of myelination" EXACT [] synonym: "up-regulation of myelination" EXACT [] synonym: "upregulation of myelination" EXACT [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042552 ! positively regulates myelination relationship: RO:0002213 GO:0042552 ! positively regulates myelination [Term] id: GO:0031644 name: regulation of nervous system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurological system process" EXACT [] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050877 ! regulates nervous system process relationship: RO:0002211 GO:0050877 ! regulates nervous system process [Term] id: GO:0031645 name: negative regulation of nervous system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurological system process" EXACT [] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050877 ! negatively regulates nervous system process relationship: RO:0002212 GO:0050877 ! negatively regulates nervous system process [Term] id: GO:0031646 name: positive regulation of nervous system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurological system process" EXACT [] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050877 ! positively regulates nervous system process relationship: RO:0002213 GO:0050877 ! positively regulates nervous system process [Term] id: GO:0031727 name: CCR2 chemokine receptor binding namespace: molecular_function def: "Binding to a CCR2 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR2 chemokine receptor ligand" NARROW [] synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001199 ! has primary input C-C chemokine receptor type 2 relationship: RO:0004009 PR:000001199 ! has primary input C-C chemokine receptor type 2 [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0005635 ! part of nuclear envelope [Term] id: GO:0031966 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] xref: NIF_Subcellular:sao1045389829 is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0005740 ! part of mitochondrial envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle relationship: BFO:0000050 GO:0043229 ! part of intracellular organelle [Term] id: GO:0031968 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] is_a: GO:0019867 ! outer membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0031967 ! part of organelle envelope intersection_of: RO:0002007 GO:0043226 ! bounding layer of organelle relationship: BFO:0000050 GO:0031967 ! part of organelle envelope [Term] id: GO:0031969 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: Wikipedia:Chloroplast_membrane is_a: GO:0042170 ! plastid membrane relationship: BFO:0000050 GO:0009941 ! part of chloroplast envelope [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0045202 ! synapse [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0070013 ! intracellular organelle lumen relationship: BFO:0000050 GO:0005634 ! part of nucleus [Term] id: GO:0031982 name: vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0032042 name: mitochondrial DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA metabolism" EXACT [] synonym: "mtDNA metabolic process" EXACT [] synonym: "mtDNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process intersection_of: GO:0006259 ! DNA metabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0032043 name: mitochondrial DNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA breakdown" EXACT [] synonym: "mitochondrial DNA catabolism" EXACT [] synonym: "mitochondrial DNA degradation" EXACT [] synonym: "mtDNA breakdown" EXACT [] synonym: "mtDNA catabolic process" EXACT [] synonym: "mtDNA catabolism" EXACT [] synonym: "mtDNA degradation" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0032042 ! mitochondrial DNA metabolic process intersection_of: GO:0006308 ! DNA catabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion [Term] id: GO:0032055 name: negative regulation of translation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation in response to stress" EXACT [] synonym: "down-regulation of translation in response to stress" EXACT [] synonym: "downregulation of translation in response to stress" EXACT [] synonym: "inhibition of translation in response to stress" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043555 ! regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0032056 name: positive regulation of translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation in response to stress" NARROW [] synonym: "stimulation of translation in response to stress" NARROW [] synonym: "up regulation of translation in response to stress" EXACT [] synonym: "up-regulation of translation in response to stress" EXACT [] synonym: "upregulation of translation in response to stress" EXACT [] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002213 GO:0006412 ! positively regulates translation [Term] id: GO:0032057 name: negative regulation of translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation initiation in response to stress" EXACT [] synonym: "down-regulation of translation initiation in response to stress" EXACT [] synonym: "downregulation of translation initiation in response to stress" EXACT [] synonym: "inhibition of translation initiation in response to stress" NARROW [] is_a: GO:0045947 ! negative regulation of translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0006950 ! part of response to stress intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation relationship: BFO:0000050 GO:0006950 ! part of response to stress [Term] id: GO:0032058 name: positive regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation initiation in response to stress" NARROW [] synonym: "stimulation of translation initiation in response to stress" NARROW [] synonym: "up regulation of translation initiation in response to stress" EXACT [] synonym: "up-regulation of translation initiation in response to stress" EXACT [] synonym: "upregulation of translation initiation in response to stress" EXACT [] is_a: GO:0045948 ! positive regulation of translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0006950 ! part of response to stress intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation relationship: BFO:0000050 GO:0006950 ! part of response to stress [Term] id: GO:0032059 name: bleb namespace: cellular_component def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] subset: goslim_pir synonym: "plasma membrane bleb" EXACT [GOC:pr] xref: Wikipedia:Bleb_(cell_biology) is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] synonym: "blebbing" BROAD [GOC:pr] synonym: "cell blebbing" EXACT [] synonym: "membrane blebbing" BROAD [GOC:pr] synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] synonym: "plasma membrane blebbing" EXACT [GOC:pr] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032059 ! results in assembly of bleb relationship: RO:0002588 GO:0032059 ! results in assembly of bleb [Term] id: GO:0032065 name: maintenance of protein location in cell cortex namespace: biological_process def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] synonym: "cortical protein anchoring" RELATED [] is_a: GO:0032507 ! maintenance of protein location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005938 ! occurs in cell cortex relationship: BFO:0000066 GO:0005938 ! occurs in cell cortex [Term] id: GO:0032074 name: negative regulation of nuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "down regulation of nuclease activity" EXACT [] synonym: "down-regulation of nuclease activity" EXACT [] synonym: "downregulation of nuclease activity" EXACT [] synonym: "inhibition of nuclease activity" NARROW [] synonym: "nuclease inhibitor" RELATED [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0004518 ! negatively regulates nuclease activity relationship: RO:0002212 GO:0004518 ! negatively regulates nuclease activity [Term] id: GO:0032075 name: positive regulation of nuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of nuclease activity" NARROW [] synonym: "nuclease activator" RELATED [] synonym: "stimulation of nuclease activity" NARROW [] synonym: "up regulation of nuclease activity" EXACT [] synonym: "up-regulation of nuclease activity" EXACT [] synonym: "upregulation of nuclease activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0004518 ! positively regulates nuclease activity relationship: RO:0002213 GO:0004518 ! positively regulates nuclease activity [Term] id: GO:0032076 name: negative regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "deoxyribonuclease inhibitor" RELATED [] synonym: "DNase inhibitor" RELATED [] synonym: "down regulation of deoxyribonuclease activity" EXACT [] synonym: "down-regulation of deoxyribonuclease activity" EXACT [] synonym: "downregulation of deoxyribonuclease activity" EXACT [] synonym: "inhibition of deoxyribonuclease activity" NARROW [] is_a: GO:0032074 ! negative regulation of nuclease activity is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0004536 ! negatively regulates DNA nuclease activity relationship: RO:0002212 GO:0004536 ! negatively regulates DNA nuclease activity [Term] id: GO:0032077 name: positive regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activator" RELATED [] synonym: "DNase activator" RELATED [] synonym: "stimulation of deoxyribonuclease activity" NARROW [] synonym: "up regulation of deoxyribonuclease activity" EXACT [] synonym: "up-regulation of deoxyribonuclease activity" EXACT [] synonym: "upregulation of deoxyribonuclease activity" EXACT [] is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:0051054 ! positive regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0004536 ! positively regulates DNA nuclease activity relationship: RO:0002213 GO:0004536 ! positively regulates DNA nuclease activity [Term] id: GO:0032091 name: negative regulation of protein binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] subset: gocheck_do_not_annotate synonym: "down regulation of protein binding" EXACT [] synonym: "down-regulation of protein binding" EXACT [] synonym: "downregulation of protein binding" EXACT [] synonym: "inhibition of protein binding" NARROW [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005515 ! negatively regulates protein binding relationship: RO:0002212 GO:0005515 ! negatively regulates protein binding [Term] id: GO:0032092 name: positive regulation of protein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] subset: gocheck_do_not_annotate synonym: "activation of protein binding" NARROW [] synonym: "stimulation of protein binding" NARROW [] synonym: "up regulation of protein binding" EXACT [] synonym: "up-regulation of protein binding" EXACT [] synonym: "upregulation of protein binding" EXACT [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005515 ! positively regulates protein binding relationship: RO:0002213 GO:0005515 ! positively regulates protein binding [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009605 ! regulates response to external stimulus relationship: RO:0002211 GO:0009605 ! regulates response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus relationship: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009605 ! positively regulates response to external stimulus relationship: RO:0002213 GO:0009605 ! positively regulates response to external stimulus [Term] id: GO:0032127 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] synonym: "dense core vesicle membrane" EXACT [GOC:kmv] is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0031045 ! bounding layer of dense core granule relationship: RO:0002007 GO:0031045 ! bounding layer of dense core granule [Term] id: GO:0032179 name: germ tube namespace: cellular_component def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] subset: goslim_pir xref: Wikipedia:Germ_tube is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic relationship: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic [Term] id: GO:0032223 name: negative regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic relationship: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic [Term] id: GO:0032224 name: positive regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "activation of synaptic transmission, cholinergic" NARROW [] synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic relationship: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic [Term] id: GO:0032228 name: regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051932 ! regulates synaptic transmission, GABAergic relationship: RO:0002211 GO:0051932 ! regulates synaptic transmission, GABAergic [Term] id: GO:0032229 name: negative regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050805 ! negative regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051932 ! negatively regulates synaptic transmission, GABAergic relationship: RO:0002212 GO:0051932 ! negatively regulates synaptic transmission, GABAergic [Term] id: GO:0032230 name: positive regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "activation of synaptic transmission, GABAergic" NARROW [] synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050806 ! positive regulation of synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051932 ! positively regulates synaptic transmission, GABAergic relationship: RO:0002213 GO:0051932 ! positively regulates synaptic transmission, GABAergic [Term] id: GO:0032231 name: regulation of actin filament bundle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0110053 ! regulation of actin filament organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly relationship: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly [Term] id: GO:0032232 name: negative regulation of actin filament bundle assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "down regulation of actin filament bundle formation" EXACT [] synonym: "down-regulation of actin filament bundle formation" EXACT [] synonym: "downregulation of actin filament bundle formation" EXACT [] synonym: "inhibition of actin filament bundle formation" NARROW [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly relationship: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly [Term] id: GO:0032233 name: positive regulation of actin filament bundle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "activation of actin filament bundle formation" NARROW [] synonym: "stimulation of actin filament bundle formation" NARROW [] synonym: "up regulation of actin filament bundle formation" EXACT [] synonym: "up-regulation of actin filament bundle formation" EXACT [] synonym: "upregulation of actin filament bundle formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly relationship: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport relationship: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport [Term] id: GO:0032240 name: negative regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport relationship: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport [Term] id: GO:0032241 name: positive regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport relationship: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport [Term] id: GO:0032252 name: secretory granule localization namespace: biological_process def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0030141 ! has primary input secretory granule relationship: RO:0004009 GO:0030141 ! has primary input secretory granule [Term] id: GO:0032253 name: dense core granule localization namespace: biological_process def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "dense core granule clustering" RELATED [] synonym: "dense core granule localisation" EXACT [GOC:mah] synonym: "dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032252 ! secretory granule localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule relationship: RO:0004009 GO:0031045 ! has primary input dense core granule [Term] id: GO:0032271 name: regulation of protein polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "regulation of protein polymerisation" EXACT [] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051258 ! regulates protein polymerization relationship: RO:0002211 GO:0051258 ! regulates protein polymerization [Term] id: GO:0032272 name: negative regulation of protein polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "down regulation of protein polymerization" EXACT [] synonym: "down-regulation of protein polymerization" EXACT [] synonym: "downregulation of protein polymerization" EXACT [] synonym: "inhibition of protein polymerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051258 ! negatively regulates protein polymerization relationship: RO:0002212 GO:0051258 ! negatively regulates protein polymerization [Term] id: GO:0032273 name: positive regulation of protein polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "activation of protein polymerization" NARROW [] synonym: "stimulation of protein polymerization" NARROW [] synonym: "up regulation of protein polymerization" EXACT [] synonym: "up-regulation of protein polymerization" EXACT [] synonym: "upregulation of protein polymerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051258 ! positively regulates protein polymerization relationship: RO:0002213 GO:0051258 ! positively regulates protein polymerization [Term] id: GO:0032274 name: gonadotropin secretion namespace: biological_process def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544] synonym: "gonadotrophin secretion" EXACT [] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032275 name: luteinizing hormone secretion namespace: biological_process def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0032276 name: regulation of gonadotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "regulation of gonadotrophin secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032274 ! regulates gonadotropin secretion relationship: RO:0002211 GO:0032274 ! regulates gonadotropin secretion [Term] id: GO:0032277 name: negative regulation of gonadotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "down regulation of gonadotropin secretion" EXACT [] synonym: "down-regulation of gonadotropin secretion" EXACT [] synonym: "downregulation of gonadotropin secretion" EXACT [] synonym: "inhibition of gonadotropin secretion" NARROW [] synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032274 ! negatively regulates gonadotropin secretion relationship: RO:0002212 GO:0032274 ! negatively regulates gonadotropin secretion [Term] id: GO:0032278 name: positive regulation of gonadotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "activation of gonadotropin secretion" NARROW [] synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph] synonym: "stimulation of gonadotropin secretion" NARROW [] synonym: "up regulation of gonadotropin secretion" EXACT [] synonym: "up-regulation of gonadotropin secretion" EXACT [] synonym: "upregulation of gonadotropin secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032274 ! positively regulates gonadotropin secretion relationship: RO:0002213 GO:0032274 ! positively regulates gonadotropin secretion [Term] id: GO:0032288 name: myelin assembly namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb] synonym: "myelin formation" RELATED [GOC:dph, GOC:tb] synonym: "myelin sheath assembly" EXACT [] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043209 ! results in assembly of myelin sheath relationship: BFO:0000050 GO:0042552 ! part of myelination relationship: RO:0002588 GO:0043209 ! results in assembly of myelin sheath [Term] id: GO:0032289 name: central nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] synonym: "central nervous system myelin sheath formation" EXACT [] synonym: "myelin formation in central nervous system" EXACT [] is_a: GO:0032288 ! myelin assembly intersection_of: GO:0032288 ! myelin assembly intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: BFO:0000050 GO:0022010 ! part of central nervous system myelination [Term] id: GO:0032290 name: peripheral nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system." [GOC:dgh] synonym: "myelin formation in peripheral nervous system" EXACT [] synonym: "peripheral nervous system myelin sheath formation" EXACT [] is_a: GO:0032288 ! myelin assembly intersection_of: GO:0032288 ! myelin assembly intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system relationship: BFO:0000050 GO:0022011 ! part of myelination in peripheral nervous system [Term] id: GO:0032291 name: axon ensheathment in central nervous system namespace: biological_process def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in central nervous system" EXACT [] is_a: GO:0008366 ! axon ensheathment intersection_of: GO:0008366 ! axon ensheathment intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: BFO:0000066 UBERON:0001017 ! occurs in central nervous system relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: GO:0032292 name: peripheral nervous system axon ensheathment namespace: biological_process def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in peripheral nervous system" EXACT [] is_a: GO:0008366 ! axon ensheathment intersection_of: GO:0008366 ! axon ensheathment intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system relationship: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system [Term] id: GO:0032330 name: regulation of chondrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation relationship: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation [Term] id: GO:0032331 name: negative regulation of chondrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "down regulation of chondrocyte differentiation" EXACT [] synonym: "down-regulation of chondrocyte differentiation" EXACT [] synonym: "downregulation of chondrocyte differentiation" EXACT [] synonym: "inhibition of chondrocyte differentiation" NARROW [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0061037 ! negative regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation relationship: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation [Term] id: GO:0032332 name: positive regulation of chondrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "activation of chondrocyte differentiation" NARROW [] synonym: "stimulation of chondrocyte differentiation" NARROW [] synonym: "up regulation of chondrocyte differentiation" EXACT [] synonym: "up-regulation of chondrocyte differentiation" EXACT [] synonym: "upregulation of chondrocyte differentiation" EXACT [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0061036 ! positive regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation relationship: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation [Term] id: GO:0032350 name: regulation of hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "regulation of hormone metabolism" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042445 ! regulates hormone metabolic process relationship: RO:0002211 GO:0042445 ! regulates hormone metabolic process [Term] id: GO:0032351 name: negative regulation of hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "down regulation of hormone metabolic process" EXACT [] synonym: "down-regulation of hormone metabolic process" EXACT [] synonym: "downregulation of hormone metabolic process" EXACT [] synonym: "inhibition of hormone metabolic process" NARROW [] synonym: "negative regulation of hormone metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042445 ! negatively regulates hormone metabolic process relationship: RO:0002212 GO:0042445 ! negatively regulates hormone metabolic process [Term] id: GO:0032352 name: positive regulation of hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "activation of hormone metabolic process" NARROW [] synonym: "positive regulation of hormone metabolism" EXACT [] synonym: "stimulation of hormone metabolic process" NARROW [] synonym: "up regulation of hormone metabolic process" EXACT [] synonym: "up-regulation of hormone metabolic process" EXACT [] synonym: "upregulation of hormone metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042445 ! positively regulates hormone metabolic process relationship: RO:0002213 GO:0042445 ! positively regulates hormone metabolic process [Term] id: GO:0032353 name: negative regulation of hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "down regulation of hormone biosynthetic process" EXACT [] synonym: "down-regulation of hormone biosynthetic process" EXACT [] synonym: "downregulation of hormone biosynthetic process" EXACT [] synonym: "inhibition of hormone biosynthetic process" NARROW [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042446 ! negatively regulates hormone biosynthetic process relationship: RO:0002212 GO:0042446 ! negatively regulates hormone biosynthetic process [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006869 ! regulates lipid transport relationship: RO:0002211 GO:0006869 ! regulates lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport is_a: GO:1905953 ! negative regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006869 ! negatively regulates lipid transport relationship: RO:0002212 GO:0006869 ! negatively regulates lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:1905954 ! positive regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006869 ! positively regulates lipid transport relationship: RO:0002213 GO:0006869 ! positively regulates lipid transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032365 ! regulates intracellular lipid transport relationship: RO:0002211 GO:0032365 ! regulates intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport relationship: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport relationship: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] subset: gocheck_do_not_annotate is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046907 ! regulates intracellular transport relationship: RO:0002211 GO:0046907 ! regulates intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046907 ! negatively regulates intracellular transport relationship: RO:0002212 GO:0046907 ! negatively regulates intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046907 ! positively regulates intracellular transport relationship: RO:0002213 GO:0046907 ! positively regulates intracellular transport [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005215 ! regulates transporter activity relationship: RO:0002211 GO:0005215 ! regulates transporter activity [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005215 ! negatively regulates transporter activity relationship: RO:0002212 GO:0005215 ! negatively regulates transporter activity [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] subset: gocheck_obsoletion_candidate synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005215 ! positively regulates transporter activity relationship: RO:0002213 GO:0005215 ! positively regulates transporter activity [Term] id: GO:0032412 name: regulation of monoatomic ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "regulation of ion transmembrane transporter activity" BROAD [] synonym: "regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015075 ! regulates monoatomic ion transmembrane transporter activity relationship: RO:0002211 GO:0015075 ! regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity relationship: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] subset: gocheck_obsoletion_candidate synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity relationship: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity [Term] id: GO:0032418 name: lysosome localization namespace: biological_process def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "lysosome localisation" EXACT [GOC:mah] is_a: GO:1990849 ! vacuolar localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005764 ! has primary input lysosome relationship: RO:0004009 GO:0005764 ! has primary input lysosome [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton relationship: BFO:0000051 GO:0005884 ! has part actin filament [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0032507 name: maintenance of protein location in cell namespace: biological_process def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0032528 name: microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] synonym: "microvillus organisation" EXACT [GOC:mah] synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005902 ! results in organization of microvillus relationship: RO:0002592 GO:0005902 ! results in organization of microvillus [Term] id: GO:0032530 name: regulation of microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] synonym: "regulation of microvillus organisation" EXACT [GOC:mah] synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032528 ! regulates microvillus organization relationship: RO:0002211 GO:0032528 ! regulates microvillus organization [Term] id: GO:0032534 name: regulation of microvillus assembly namespace: biological_process def: "A process that modulates the formation of a microvillus." [GOC:mah] synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030033 ! regulates microvillus assembly relationship: RO:0002211 GO:0030033 ! regulates microvillus assembly [Term] id: GO:0032543 name: mitochondrial translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] subset: goslim_yeast synonym: "mitochondrial protein anabolism" EXACT [] synonym: "mitochondrial protein biosynthesis" EXACT [] synonym: "mitochondrial protein formation" EXACT [] synonym: "mitochondrial protein synthesis" EXACT [] synonym: "mitochondrial protein translation" EXACT [] xref: Reactome:R-HSA-5368287 "Mitochondrial translation" is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: BFO:0000050 GO:0140053 ! part of mitochondrial gene expression intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0140053 ! part of mitochondrial gene expression [Term] id: GO:0032544 name: plastid translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] synonym: "plastid protein anabolism" EXACT [] synonym: "plastid protein biosynthesis" EXACT [] synonym: "plastid protein formation" EXACT [] synonym: "plastid protein synthesis" EXACT [] synonym: "plastid protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0009657 ! plastid organization intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid relationship: BFO:0000066 GO:0009536 ! occurs in plastid [Term] id: GO:0032589 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0043005 ! bounding layer of neuron projection relationship: RO:0002007 GO:0043005 ! bounding layer of neuron projection [Term] id: GO:0032590 name: dendrite membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0030425 ! bounding layer of dendrite relationship: RO:0002007 GO:0030425 ! bounding layer of dendrite [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0061024 ! membrane organization intersection_of: GO:0015031 ! protein transport intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane relationship: BFO:0000066 GO:0016020 ! occurs in membrane [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process alt_id: GO:0062103 def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. subset: gocheck_do_not_annotate synonym: "double-stranded RNA biosynthesis" NARROW [] synonym: "double-stranded RNA biosynthetic process" NARROW [] synonym: "dsRNA biosynthesis" NARROW [] synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0141187 ! nucleic acid biosynthetic process intersection_of: GO:0009059 ! macromolecule biosynthetic process intersection_of: RO:0004008 CHEBI:33697 ! has primary output ribonucleic acid relationship: RO:0004008 CHEBI:33697 ! has primary output ribonucleic acid [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35757 ! has primary input or output monocarboxylic acid anion relationship: RO:0004007 CHEBI:35757 ! has primary input or output monocarboxylic acid anion [Term] id: GO:0032790 name: ribosome disassembly namespace: biological_process def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] synonym: "ribosome dissociation factor" RELATED [] synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391] is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005840 ! results in disassembly of ribosome relationship: RO:0002590 GO:0005840 ! results in disassembly of ribosome [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0120025 ! part of plasma membrane bounded cell projection relationship: BFO:0000050 GO:0120025 ! part of plasma membrane bounded cell projection [Term] id: GO:0032839 name: dendrite cytoplasm namespace: cellular_component def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] synonym: "dendritic cytoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0030425 ! part of dendrite relationship: BFO:0000050 GO:0030425 ! part of dendrite [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:1903353 ! regulation of nucleus organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000741 ! regulates karyogamy relationship: RO:0002211 GO:0000741 ! regulates karyogamy [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity relationship: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] subset: gocheck_do_not_annotate synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051179 ! regulates localization relationship: RO:0002211 GO:0051179 ! regulates localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process alt_id: GO:1903827 def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein localization" EXACT [] synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008104 ! regulates intracellular protein localization relationship: RO:0002211 GO:0008104 ! regulates intracellular protein localization created_by: jl creation_date: 2015-01-20T14:32:14Z [Term] id: GO:0032881 name: regulation of polysaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process relationship: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process [Term] id: GO:0032885 name: regulation of polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process relationship: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007017 ! regulates microtubule-based process relationship: RO:0002211 GO:0007017 ! regulates microtubule-based process [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015849 ! regulates organic acid transport relationship: RO:0002211 GO:0015849 ! regulates organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015849 ! negatively regulates organic acid transport relationship: RO:0002212 GO:0015849 ! negatively regulates organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015849 ! positively regulates organic acid transport relationship: RO:0002213 GO:0015849 ! positively regulates organic acid transport [Term] id: GO:0032938 name: negative regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress is_a: GO:0043558 ! regulation of translational initiation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation [Term] id: GO:0032939 name: positive regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "activation of translation in response to oxidative stress" NARROW [] synonym: "stimulation of translation in response to oxidative stress" NARROW [] synonym: "up regulation of translation in response to oxidative stress" EXACT [] synonym: "up-regulation of translation in response to oxidative stress" EXACT [] synonym: "upregulation of translation in response to oxidative stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress intersection_of: RO:0002213 GO:0006412 ! positively regulates translation relationship: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0046903 ! secretion is_a: GO:0140352 ! export from cell [Term] id: GO:0032941 name: secretion by tissue namespace: biological_process def: "The controlled release of a substance by a tissue." [GOC:mah] synonym: "expulsion of gland contents" RELATED [GOC:mah] synonym: "tissue secretion" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0046903 ! secretion [Term] id: GO:0032943 name: mononuclear cell proliferation namespace: biological_process def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "PBMC proliferation" NARROW [] synonym: "peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000842 ! acts on population of mononuclear leukocyte relationship: RO:0012003 CL:0000842 ! acts on population of mononuclear leukocyte [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "regulation of PBMC proliferation" NARROW [] synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032943 ! regulates mononuclear cell proliferation relationship: RO:0002211 GO:0032943 ! regulates mononuclear cell proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "negative regulation of PBMC proliferation" NARROW [] synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032943 ! negatively regulates mononuclear cell proliferation relationship: RO:0002212 GO:0032943 ! negatively regulates mononuclear cell proliferation [Term] id: GO:0032946 name: positive regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "activation of mononuclear cell proliferation" NARROW [] synonym: "positive regulation of PBMC proliferation" NARROW [] synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] synonym: "stimulation of mononuclear cell proliferation" NARROW [] synonym: "up regulation of mononuclear cell proliferation" EXACT [] synonym: "up-regulation of mononuclear cell proliferation" EXACT [] synonym: "upregulation of mononuclear cell proliferation" EXACT [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070665 ! positive regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032943 ! positively regulates mononuclear cell proliferation relationship: RO:0002213 GO:0032943 ! positively regulates mononuclear cell proliferation [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization relationship: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization [Term] id: GO:0032963 name: collagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 GO:0005581 ! has primary input or output collagen trimer relationship: RO:0004007 GO:0005581 ! has primary input or output collagen trimer [Term] id: GO:0032964 name: collagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen anabolism" EXACT [] synonym: "collagen biosynthesis" EXACT [] synonym: "collagen formation" EXACT [] synonym: "collagen synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0032963 ! collagen metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 GO:0005581 ! has primary output collagen trimer relationship: RO:0004008 GO:0005581 ! has primary output collagen trimer [Term] id: GO:0032965 name: regulation of collagen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "regulation of collagen anabolism" EXACT [] synonym: "regulation of collagen biosynthesis" EXACT [] synonym: "regulation of collagen formation" EXACT [] synonym: "regulation of collagen synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010712 ! regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process relationship: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process [Term] id: GO:0032966 name: negative regulation of collagen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "negative regulation of collagen anabolism" EXACT [] synonym: "negative regulation of collagen biosynthesis" EXACT [] synonym: "negative regulation of collagen formation" EXACT [] synonym: "negative regulation of collagen synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010713 ! negative regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process relationship: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process [Term] id: GO:0032967 name: positive regulation of collagen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "positive regulation of collagen anabolism" EXACT [] synonym: "positive regulation of collagen biosynthesis" EXACT [] synonym: "positive regulation of collagen formation" EXACT [] synonym: "positive regulation of collagen synthesis" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010714 ! positive regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process relationship: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030029 ! regulates actin filament-based process relationship: RO:0002211 GO:0030029 ! regulates actin filament-based process [Term] id: GO:0032973 name: amino acid export across plasma membrane namespace: biological_process def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl] synonym: "amino acid efflux" EXACT [] synonym: "amino acid export" BROAD [] synonym: "amino acid transmembrane export" BROAD [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0140115 ! export across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion creation_date: 2012-11-14T14:27:40Z [Term] id: GO:0032974 name: amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] synonym: "amino acid efflux from vacuole" EXACT [] synonym: "vacuolar amino acid export" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0002338 GO:0005775 ! has target start location vacuolar lumen relationship: RO:0002339 GO:0005829 ! has target end location cytosol [Term] id: GO:0032975 name: amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah] synonym: "vacuolar amino acid import" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005775 ! has target end location vacuolar lumen [Term] id: GO:0032984 name: protein-containing complex disassembly namespace: biological_process alt_id: GO:0034623 alt_id: GO:0043241 alt_id: GO:0043624 def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] synonym: "cellular macromolecule complex disassembly" RELATED [] synonym: "cellular protein complex disassembly" RELATED [] synonym: "macromolecule complex disassembly" RELATED [] synonym: "protein complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex relationship: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex [Term] id: GO:0032988 name: protein-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "ribonucleoprotein complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071826 ! protein-RNA complex organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex relationship: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex [Term] id: GO:0032989 name: cellular anatomical entity morphogenesis namespace: biological_process def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular component morphogenesis" EXACT [] synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component disjoint_from: GO:0044423 ! virion component disjoint_from: GO:0110165 ! cellular anatomical structure relationship: BFO:0000051 PR:000000001 ! has part protein [Term] id: GO:0033002 name: muscle cell proliferation namespace: biological_process def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] synonym: "myocyte proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000187 ! acts on population of muscle cell relationship: RO:0012003 CL:0000187 ! acts on population of muscle cell [Term] id: GO:0033028 name: myeloid cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093] synonym: "apoptosis of myeloid cells" EXACT [] synonym: "myeloid cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000763 ! occurs in myeloid cell relationship: BFO:0000066 CL:0000763 ! occurs in myeloid cell [Term] id: GO:0033032 name: regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process relationship: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process [Term] id: GO:0033033 name: negative regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of myeloid cell apoptosis" EXACT [] synonym: "down-regulation of myeloid cell apoptosis" EXACT [] synonym: "downregulation of myeloid cell apoptosis" EXACT [] synonym: "inhibition of myeloid cell apoptosis" NARROW [] synonym: "negative regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process relationship: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process [Term] id: GO:0033034 name: positive regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of myeloid cell apoptosis" NARROW [] synonym: "positive regulation of myeloid cell apoptosis" NARROW [] synonym: "stimulation of myeloid cell apoptosis" NARROW [] synonym: "up regulation of myeloid cell apoptosis" EXACT [] synonym: "up-regulation of myeloid cell apoptosis" EXACT [] synonym: "upregulation of myeloid cell apoptosis" EXACT [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process relationship: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006996 ! regulates organelle organization relationship: RO:0002211 GO:0006996 ! regulates organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051276 ! regulates chromosome organization relationship: RO:0002211 GO:0051276 ! regulates chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000819 ! regulates sister chromatid segregation relationship: RO:0002211 GO:0000819 ! regulates sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation relationship: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation relationship: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation relationship: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033157 name: regulation of intracellular protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006886 ! regulates intracellular protein transport relationship: RO:0002211 GO:0006886 ! regulates intracellular protein transport [Term] id: GO:0033218 name: amide binding namespace: molecular_function def: "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide relationship: RO:0004009 CHEBI:32988 ! has primary input amide [Term] id: GO:0033238 name: regulation of amine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] synonym: "regulation of amine metabolism" EXACT [] synonym: "regulation of cellular amine metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009308 ! regulates amine metabolic process relationship: RO:0002211 GO:0009308 ! regulates amine metabolic process [Term] id: GO:0033239 name: negative regulation of amine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "negative regulation of amine metabolism" EXACT [] synonym: "negative regulation of cellular amine metabolic process" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process relationship: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process [Term] id: GO:0033240 name: positive regulation of amine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] synonym: "positive regulation of amine metabolism" EXACT [] synonym: "positive regulation of cellular amine metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009308 ! positively regulates amine metabolic process relationship: RO:0002213 GO:0009308 ! positively regulates amine metabolic process [Term] id: GO:0033241 name: regulation of amine catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "regulation of amine breakdown" EXACT [] synonym: "regulation of amine catabolism" EXACT [] synonym: "regulation of amine degradation" EXACT [] synonym: "regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0033238 ! regulation of amine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009310 ! regulates amine catabolic process relationship: RO:0002211 GO:0009310 ! regulates amine catabolic process [Term] id: GO:0033242 name: negative regulation of amine catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "negative regulation of amine breakdown" EXACT [] synonym: "negative regulation of amine catabolism" EXACT [] synonym: "negative regulation of amine degradation" EXACT [] synonym: "negative regulation of cellular amine catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process relationship: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process [Term] id: GO:0033243 name: positive regulation of amine catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] synonym: "positive regulation of amine breakdown" EXACT [] synonym: "positive regulation of amine catabolism" EXACT [] synonym: "positive regulation of amine degradation" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0033241 ! regulation of amine catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009310 ! positively regulates amine catabolic process relationship: RO:0002213 GO:0009310 ! positively regulates amine catabolic process [Term] id: GO:0033278 name: cell proliferation in midbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf] synonym: "cell proliferation in mesencephalon" EXACT [] synonym: "mesencepahalic cell proliferation" RELATED [] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000066 UBERON:0001891 ! occurs in midbrain relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: BFO:0000066 UBERON:0001891 ! occurs in midbrain [Term] id: GO:0033293 name: monocarboxylic acid binding namespace: molecular_function def: "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] is_a: GO:0031406 ! carboxylic acid binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion [Term] id: GO:0033326 name: cerebrospinal fluid secretion namespace: biological_process def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, PMID:10716451] synonym: "CSF secretion" EXACT [] is_a: GO:0007589 ! body fluid secretion is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0033363 name: secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "secretory granule organisation" EXACT [GOC:mah] synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization relationship: RO:0002592 GO:0030141 ! results in organization of secretory granule [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] subset: gocheck_do_not_annotate synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0043226 ! has target end location organelle relationship: RO:0002339 GO:0043226 ! has target end location organelle [Term] id: GO:0033366 name: protein localization to secretory granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] synonym: "protein localisation in secretory granule" EXACT [GOC:mah] synonym: "protein localization in secretory granule" EXACT [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule relationship: RO:0002339 GO:0030141 ! has target end location secretory granule [Term] id: GO:0033371 name: T cell secretory granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] synonym: "T cell secretory granule organisation" EXACT [GOC:mah] synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah] synonym: "T lymphocyte secretory granule organization" EXACT [] synonym: "T-cell secretory granule organization" EXACT [] synonym: "T-lymphocyte secretory granule maturation" RELATED [] synonym: "T-lymphocyte secretory granule organization" EXACT [] is_a: GO:0033363 ! secretory granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0033504 name: floor plate development namespace: biological_process def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003306 ! results in development of floor plate of neural tube relationship: BFO:0000050 GO:0021915 ! part of neural tube development relationship: RO:0002296 UBERON:0003306 ! results in development of floor plate of neural tube [Term] id: GO:0033505 name: floor plate morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003079 ! results in morphogenesis of floor plate relationship: BFO:0000050 GO:0033504 ! part of floor plate development relationship: RO:0002298 UBERON:0003079 ! results in morphogenesis of floor plate [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] xref: Reactome:R-HSA-2262752 "Cellular responses to stress" is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0033604 name: negative regulation of catecholamine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "down regulation of catecholamine secretion" EXACT [] synonym: "down-regulation of catecholamine secretion" EXACT [] synonym: "downregulation of catecholamine secretion" EXACT [] synonym: "inhibition of catecholamine secretion" NARROW [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion relationship: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion [Term] id: GO:0033605 name: positive regulation of catecholamine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] synonym: "activation of catecholamine secretion" NARROW [] synonym: "stimulation of catecholamine secretion" NARROW [] synonym: "up regulation of catecholamine secretion" EXACT [] synonym: "up-regulation of catecholamine secretion" EXACT [] synonym: "upregulation of catecholamine secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion relationship: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion [Term] id: GO:0033684 name: regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] is_a: GO:0032276 ! regulation of gonadotropin secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032275 ! regulates luteinizing hormone secretion relationship: RO:0002211 GO:0032275 ! regulates luteinizing hormone secretion [Term] id: GO:0033685 name: negative regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "down regulation of luteinizing hormone secretion" EXACT [] synonym: "down-regulation of luteinizing hormone secretion" EXACT [] synonym: "downregulation of luteinizing hormone secretion" EXACT [] synonym: "inhibition of luteinizing hormone secretion" NARROW [] is_a: GO:0032277 ! negative regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032275 ! negatively regulates luteinizing hormone secretion relationship: RO:0002212 GO:0032275 ! negatively regulates luteinizing hormone secretion [Term] id: GO:0033686 name: positive regulation of luteinizing hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] synonym: "activation of luteinizing hormone secretion" NARROW [] synonym: "stimulation of luteinizing hormone secretion" NARROW [] synonym: "up regulation of luteinizing hormone secretion" EXACT [] synonym: "up-regulation of luteinizing hormone secretion" EXACT [] synonym: "upregulation of luteinizing hormone secretion" EXACT [] is_a: GO:0032278 ! positive regulation of gonadotropin secretion is_a: GO:0033684 ! regulation of luteinizing hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032275 ! positively regulates luteinizing hormone secretion relationship: RO:0002213 GO:0032275 ! positively regulates luteinizing hormone secretion [Term] id: GO:0033750 name: ribosome localization namespace: biological_process def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "establishment of ribosome localisation" RELATED [] synonym: "establishment of ribosome localization" RELATED [] synonym: "ribosome localisation" RELATED [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome relationship: RO:0004009 GO:0005840 ! has primary input ribosome [Term] id: GO:0033993 name: response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0034050 name: symbiont-induced defense-related programmed cell death namespace: biological_process def: "Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules." [GOC:pamgo_curators] comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'symbiont-mediated activation of host programmed cell death' ; GO:0052042'. synonym: "host programmed cell death induced by symbiont" EXACT [] synonym: "programmed cell death induced by symbiont" EXACT [] is_a: GO:0012501 ! programmed cell death is_a: GO:0140546 ! defense response to symbiont [Term] id: GO:0034067 name: protein localization to Golgi apparatus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah] synonym: "establishment of protein localization in Golgi" NARROW [] synonym: "establishment of protein localization to Golgi" NARROW [] synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah] synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] synonym: "protein localization in Golgi apparatus" EXACT [] synonym: "protein targeting to Golgi" RELATED [] synonym: "protein-Golgi targeting" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus creation_date: 2011-02-14T02:26:36Z [Term] id: GO:0034097 name: response to cytokine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] synonym: "response to cytokine stimulus" EXACT [GOC:dos] xref: Reactome:R-HSA-9645135 "STAT5 Activation" is_a: GO:1901652 ! response to peptide [Term] id: GO:0034101 name: erythrocyte homeostasis namespace: biological_process def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] synonym: "RBC homeostasis" EXACT [CL:0000232] synonym: "red blood cell homeostasis" EXACT [CL:0000232] is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000232 ! acts on population of erythrocyte relationship: RO:0012003 CL:0000232 ! acts on population of erythrocyte [Term] id: GO:0034103 name: regulation of tissue remodeling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add] synonym: "regulation of tissue remodelling" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048771 ! regulates tissue remodeling relationship: RO:0002211 GO:0048771 ! regulates tissue remodeling [Term] id: GO:0034104 name: negative regulation of tissue remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add] synonym: "negative regulation of tissue remodelling" EXACT [] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048771 ! negatively regulates tissue remodeling relationship: RO:0002212 GO:0048771 ! negatively regulates tissue remodeling [Term] id: GO:0034105 name: positive regulation of tissue remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add] synonym: "positive regulation of tissue remodelling" EXACT [] is_a: GO:0034103 ! regulation of tissue remodeling is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048771 ! positively regulates tissue remodeling relationship: RO:0002213 GO:0048771 ! positively regulates tissue remodeling [Term] id: GO:0034219 name: carbohydrate transmembrane transport namespace: biological_process def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbohydrate membrane transport" EXACT [] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate [Term] id: GO:0034220 name: monoatomic ion transmembrane transport namespace: biological_process def: "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] synonym: "ion membrane transport" EXACT [] synonym: "ion transmembrane transport" BROAD [] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-983712 "Ion channel transport" is_a: GO:0006811 ! monoatomic ion transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion [Term] id: GO:0034242 name: negative regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion relationship: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion [Term] id: GO:0034248 name: regulation of amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] synonym: "regulation of cellular amide metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043603 ! regulates amide metabolic process relationship: RO:0002211 GO:0043603 ! regulates amide metabolic process [Term] id: GO:0034249 name: negative regulation of amide metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "negative regulation of amide metabolism" EXACT [] synonym: "negative regulation of cellular amide metabolic process" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process relationship: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process [Term] id: GO:0034250 name: positive regulation of amide metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "positive regulation of amide metabolism" EXACT [] synonym: "positive regulation of cellular amide metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043603 ! positively regulates amide metabolic process relationship: RO:0002213 GO:0043603 ! positively regulates amide metabolic process [Term] id: GO:0034251 name: regulation of amide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "regulation of amide breakdown" EXACT [] synonym: "regulation of amide catabolism" EXACT [] synonym: "regulation of amide degradation" EXACT [] synonym: "regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0034248 ! regulation of amide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043605 ! regulates amide catabolic process relationship: RO:0002211 GO:0043605 ! regulates amide catabolic process [Term] id: GO:0034252 name: negative regulation of amide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "negative regulation of amide breakdown" EXACT [] synonym: "negative regulation of amide catabolism" EXACT [] synonym: "negative regulation of amide degradation" RELATED [] synonym: "negative regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0034249 ! negative regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process relationship: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process [Term] id: GO:0034253 name: positive regulation of amide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] synonym: "positive regulation of amide breakdown" EXACT [] synonym: "positive regulation of amide catabolism" EXACT [] synonym: "positive regulation of amide degradation" RELATED [] synonym: "positive regulation of cellular amide catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0034250 ! positive regulation of amide metabolic process is_a: GO:0034251 ! regulation of amide catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043605 ! positively regulates amide catabolic process relationship: RO:0002213 GO:0043605 ! positively regulates amide catabolic process [Term] id: GO:0034293 name: sexual sporulation namespace: biological_process def: "The formation of spores derived from the products of meiosis." [GOC:mah] synonym: "meiotic spore formation" EXACT [] synonym: "meiotic sporulation" EXACT [] synonym: "sexual spore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0043934 ! sporulation intersection_of: GO:0043934 ! sporulation intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle relationship: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0034301 name: endospore formation namespace: biological_process def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0034305 name: regulation of asexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah] synonym: "regulation of asexual spore formation" EXACT [] synonym: "regulation of mitotic spore formation" EXACT [] synonym: "regulation of mitotic sporulation" EXACT [] is_a: GO:0043937 ! regulation of sporulation is_a: GO:1903664 ! regulation of asexual reproduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030436 ! regulates asexual sporulation relationship: RO:0002211 GO:0030436 ! regulates asexual sporulation [Term] id: GO:0034306 name: regulation of sexual sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah] synonym: "MAPKKK cascade during sporulation" RELATED [] synonym: "regulation of meiotic spore formation" EXACT [] synonym: "regulation of meiotic sporulation" EXACT [] synonym: "regulation of sexual spore formation" EXACT [] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034293 ! regulates sexual sporulation relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi relationship: RO:0002211 GO:0034293 ! regulates sexual sporulation [Term] id: GO:0034308 name: primary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol metabolic process" EXACT [] synonym: "primary alcohol metabolism" EXACT [GOC:mah] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0034309 name: primary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] synonym: "monohydric alcohol biosynthetic process" EXACT [] synonym: "primary alcohol anabolism" EXACT [GOC:mah] synonym: "primary alcohol biosynthesis" EXACT [GOC:mah] synonym: "primary alcohol formation" EXACT [GOC:mah] synonym: "primary alcohol synthesis" EXACT [GOC:mah] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0034329 name: cell junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] xref: Reactome:R-HSA-446728 "Cell junction organization" is_a: GO:0022607 ! cellular component assembly is_a: GO:0034330 ! cell junction organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0030054 ! results in assembly of cell junction relationship: RO:0002588 GO:0030054 ! results in assembly of cell junction [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] synonym: "cell junction organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030054 ! results in organization of cell junction relationship: RO:0002592 GO:0030054 ! results in organization of cell junction [Term] id: GO:0034349 name: glial cell apoptotic process namespace: biological_process def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart] synonym: "apoptosis of glia" EXACT [] synonym: "apoptosis of glial cells" EXACT [] synonym: "glia apoptosis" EXACT [] synonym: "glia programmed cell death by apoptosis" EXACT [] synonym: "glial cell apoptosis" NARROW [] synonym: "glial cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of glia by apoptosis" EXACT [] synonym: "programmed cell death of glial cells by apoptosis" EXACT [] synonym: "programmed cell death, glia" EXACT [] synonym: "programmed cell death, glial cells" EXACT [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000125 ! occurs in glial cell relationship: BFO:0000066 CL:0000125 ! occurs in glial cell [Term] id: GO:0034350 name: regulation of glial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of glial cell apoptosis" RELATED [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process relationship: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process [Term] id: GO:0034351 name: negative regulation of glial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "down regulation of glial cell apoptosis" EXACT [] synonym: "down-regulation of glial cell apoptosis" EXACT [] synonym: "downregulation of glial cell apoptosis" EXACT [] synonym: "inhibition of glial cell apoptosis" NARROW [] synonym: "negative regulation of glial cell apoptosis" NARROW [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process relationship: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process [Term] id: GO:0034352 name: positive regulation of glial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "activation of glial cell apoptosis" NARROW [] synonym: "positive regulation of glial cell apoptosis" NARROW [] synonym: "stimulation of glial cell apoptosis" NARROW [] synonym: "up regulation of glial cell apoptosis" EXACT [] synonym: "up-regulation of glial cell apoptosis" EXACT [] synonym: "upregulation of glial cell apoptosis" EXACT [] is_a: GO:0034350 ! regulation of glial cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process relationship: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process [Term] id: GO:0034390 name: smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] synonym: "apoptosis of smooth muscle cells" EXACT [] synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] synonym: "programmed cell death, smooth muscle cells" EXACT [] synonym: "SMC apoptosis" EXACT [] synonym: "smooth muscle cell apoptosis" NARROW [] synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] is_a: GO:0010657 ! muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell relationship: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell [Term] id: GO:0034391 name: regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "regulation of SMC apoptosis" EXACT [] synonym: "regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process relationship: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process [Term] id: GO:0034392 name: negative regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] synonym: "negative regulation of SMC apoptosis" EXACT [] synonym: "negative regulation of smooth muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process relationship: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process [Term] id: GO:0034393 name: positive regulation of smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] synonym: "activation of smooth muscle cell apoptosis" NARROW [] synonym: "positive regulation of SMC apoptosis" EXACT [] synonym: "positive regulation of smooth muscle cell apoptosis" NARROW [] synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process relationship: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process [Term] id: GO:0034436 name: glycoprotein transport namespace: biological_process def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0015031 ! protein transport is_a: GO:1901264 ! carbohydrate derivative transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input [Term] id: GO:0034486 name: vacuolar transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole [Term] id: GO:0034487 name: vacuolar amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar amino acid membrane transport" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane [Term] id: GO:0034489 name: neutral amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole intersection_of: GO:0015804 ! neutral amino acid transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0034491 name: neutral amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah] is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole intersection_of: GO:0015804 ! neutral amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0034502 name: protein localization to chromosome namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] synonym: "condensin localization to chromosome" NARROW [] synonym: "protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome relationship: RO:0002339 GO:0005694 ! has target end location chromosome [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process alt_id: GO:0044744 def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] synonym: "protein targeting to nucleus" RELATED [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus relationship: RO:0002339 GO:0005634 ! has target end location nucleus creation_date: 2012-11-07T15:45:54Z [Term] id: GO:0034599 name: cellular response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk] xref: Reactome:R-HSA-3299685 "Detoxification of Reactive Oxygen Species" xref: Reactome:R-HSA-9707564 "Cytoprotection by HMOX1" is_a: GO:0006979 ! response to oxidative stress is_a: GO:0062197 ! cellular response to chemical stress [Term] id: GO:0034614 name: cellular response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] synonym: "cellular response to active oxygen species" EXACT [] synonym: "cellular response to AOS" EXACT [] synonym: "cellular response to reactive oxidative species" EXACT [] synonym: "cellular response to reactive oxygen intermediate" EXACT [] synonym: "cellular response to ROI" EXACT [] synonym: "cellular response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:26523 ! has primary input reactive oxygen species [Term] id: GO:0034642 name: mitochondrion migration along actin filament namespace: biological_process def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220] synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb] synonym: "mitochondrial migration along microfilament" EXACT [] synonym: "mitochondrial migration, actin-mediated" EXACT [] synonym: "mitochondrion migration along microfilament" EXACT [] synonym: "mitochondrion transport along actin filament" EXACT [] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0051654 ! establishment of mitochondrion localization is_a: GO:0099515 ! actin filament-based transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0034643 name: establishment of mitochondrion localization, microtubule-mediated namespace: biological_process def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah] synonym: "microtubule-mediated mitochondrion localization" EXACT [] synonym: "mitochondrial localization, microtubule-mediated" EXACT [] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0051654 ! establishment of mitochondrion localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:61120 ! has primary output nucleobase-containing molecular entity relationship: RO:0004008 CHEBI:61120 ! has primary output nucleobase-containing molecular entity [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity [Term] id: GO:0034762 name: regulation of transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "regulation of membrane transport" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055085 ! regulates transmembrane transport relationship: RO:0002211 GO:0055085 ! regulates transmembrane transport [Term] id: GO:0034763 name: negative regulation of transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane transport" EXACT [] synonym: "down-regulation of transmembrane transport" EXACT [] synonym: "downregulation of transmembrane transport" EXACT [] synonym: "inhibition of transmembrane transport" NARROW [] synonym: "negative regulation of membrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport relationship: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport [Term] id: GO:0034764 name: positive regulation of transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane transport" NARROW [] synonym: "positive regulation of membrane transport" EXACT [] synonym: "stimulation of transmembrane transport" NARROW [] synonym: "up regulation of transmembrane transport" EXACT [] synonym: "up-regulation of transmembrane transport" EXACT [] synonym: "upregulation of transmembrane transport" EXACT [] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055085 ! positively regulates transmembrane transport relationship: RO:0002213 GO:0055085 ! positively regulates transmembrane transport [Term] id: GO:0034765 name: regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "regulation of ion membrane transport" EXACT [] synonym: "regulation of ion transmembrane transport" BROAD [] synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0043269 ! regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport relationship: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport [Term] id: GO:0034766 name: negative regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "down regulation of transmembrane ion transport" EXACT [] synonym: "down-regulation of transmembrane ion transport" EXACT [] synonym: "downregulation of transmembrane ion transport" EXACT [] synonym: "inhibition of transmembrane ion transport" NARROW [] synonym: "negative regulation of ion membrane transport" EXACT [] synonym: "negative regulation of ion transmembrane transport" BROAD [] synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport is_a: GO:0043271 ! negative regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport relationship: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport [Term] id: GO:0034767 name: positive regulation of monoatomic ion transmembrane transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] synonym: "activation of transmembrane ion transport" NARROW [] synonym: "positive regulation of ion membrane transport" EXACT [] synonym: "positive regulation of ion transmembrane transport" BROAD [] synonym: "positive regulation of transmembrane ion transport" EXACT [] synonym: "stimulation of transmembrane ion transport" NARROW [] synonym: "up regulation of transmembrane ion transport" EXACT [] synonym: "up-regulation of transmembrane ion transport" EXACT [] synonym: "upregulation of transmembrane ion transport" EXACT [] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport is_a: GO:0043270 ! positive regulation of monoatomic ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport relationship: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport [Term] id: GO:0034769 name: basement membrane disassembly namespace: biological_process def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. synonym: "basal lamina disassembly" RELATED [] is_a: GO:0022617 ! extracellular matrix disassembly is_a: GO:0071711 ! basement membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005604 ! results in disassembly of basement membrane relationship: RO:0002590 GO:0005604 ! results in disassembly of basement membrane creation_date: 2009-08-13T11:27:24Z [Term] id: GO:0035050 name: embryonic heart tube development namespace: biological_process def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004141 ! results in development of heart tube relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0048568 ! part of embryonic organ development relationship: RO:0002296 UBERON:0004141 ! results in development of heart tube [Term] id: GO:0035051 name: cardiocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] synonym: "cardiac cell differentiation" EXACT [] synonym: "heart cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte [Term] id: GO:0035082 name: axoneme assembly namespace: biological_process def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "axoneme biogenesis" RELATED [GOC:mah] synonym: "ciliary axoneme assembly" EXACT [] synonym: "cilium axoneme assembly" EXACT [] synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] synonym: "flagellar axoneme assembly" EXACT [] synonym: "flagellum axoneme assembly" EXACT [] is_a: GO:0001578 ! microtubule bundle formation is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005930 ! results in assembly of axoneme relationship: BFO:0000050 GO:0060271 ! part of cilium assembly relationship: RO:0002588 GO:0005930 ! results in assembly of axoneme [Term] id: GO:0035107 name: appendage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage relationship: BFO:0000050 GO:0048736 ! part of appendage development relationship: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage [Term] id: GO:0035112 name: genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] synonym: "genital morphogenesis" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system relationship: BFO:0000050 GO:0048806 ! part of genitalia development relationship: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system [Term] id: GO:0035148 name: tube formation namespace: biological_process def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000025 ! results in formation of tube relationship: BFO:0000050 GO:0035239 ! part of tube morphogenesis relationship: RO:0002297 UBERON:0000025 ! results in formation of tube [Term] id: GO:0035190 name: syncytial nuclear migration namespace: biological_process def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] is_a: GO:0007097 ! nuclear migration intersection_of: GO:0007097 ! nuclear migration intersection_of: BFO:0000066 CL:0000228 ! occurs in multinucleate cell relationship: BFO:0000050 GO:0001700 ! part of embryonic development via the syncytial blastoderm relationship: BFO:0000066 CL:0000228 ! occurs in multinucleate cell [Term] id: GO:0035234 name: ectopic germ cell programmed cell death namespace: biological_process def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] synonym: "programmed cell death of ectopic germ cells" EXACT [] synonym: "programmed cell death, ectopic germ cells" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development intersection_of: GO:0012501 ! programmed cell death intersection_of: BFO:0000066 CL:0000586 ! occurs in germ cell relationship: BFO:0000066 CL:0000586 ! occurs in germ cell [Term] id: GO:0035239 name: tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube relationship: BFO:0000050 GO:0035295 ! part of tube development relationship: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube [Term] id: GO:0035249 name: synaptic transmission, glutamatergic namespace: biological_process def: "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] synonym: "glutamatergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0035260 name: internal genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [PMID:24793987, PMID:25247640] is_a: GO:0035112 ! genitalia morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia relationship: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia [Term] id: GO:0035261 name: external genitalia morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [PMID:24793987, PMID:25247640] is_a: GO:0035112 ! genitalia morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia relationship: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia [Term] id: GO:0035262 name: gonad morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad relationship: BFO:0000050 GO:0008406 ! part of gonad development relationship: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad [Term] id: GO:0035264 name: multicellular organism growth namespace: biological_process def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] synonym: "body growth" RELATED [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism relationship: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism [Term] id: GO:0035265 name: organ growth namespace: biological_process def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000062 ! results in growth of organ relationship: RO:0002343 UBERON:0000062 ! results in growth of organ [Term] id: GO:0035270 name: endocrine system development namespace: biological_process def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000949 ! results in development of endocrine system relationship: RO:0002296 UBERON:0000949 ! results in development of endocrine system [Term] id: GO:0035272 name: exocrine system development namespace: biological_process def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002330 ! results in development of exocrine system relationship: RO:0002296 UBERON:0002330 ! results in development of exocrine system [Term] id: GO:0035282 name: segmentation namespace: biological_process def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] xref: Wikipedia:Segmentation_(biology) is_a: GO:0003002 ! regionalization [Term] id: GO:0035290 name: trunk segmentation namespace: biological_process def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] is_a: GO:0035282 ! segmentation relationship: BFO:0000050 GO:0007350 ! part of blastoderm segmentation [Term] id: GO:0035295 name: tube development namespace: biological_process def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000025 ! results in development of tube relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0000025 ! results in development of tube [Term] id: GO:0035372 name: protein localization to microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] synonym: "protein localisation to microtubule" EXACT [GOC:mah] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005874 ! has target end location microtubule relationship: RO:0002339 GO:0005874 ! has target end location microtubule creation_date: 2010-03-11T11:00:56Z [Term] id: GO:0035418 name: protein localization to synapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] synonym: "protein localisation to synapse" EXACT [GOC:mah] is_a: GO:1902414 ! protein localization to cell junction intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0045202 ! has target end location synapse relationship: RO:0002339 GO:0045202 ! has target end location synapse creation_date: 2010-03-29T10:58:53Z [Term] id: GO:0035441 name: cell migration involved in vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0001570 ! part of vasculogenesis relationship: BFO:0000050 GO:0001570 ! part of vasculogenesis creation_date: 2010-04-09T03:53:01Z [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0007243 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] subset: goslim_drosophila synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling pathway" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure created_by: bf creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035562 name: negative regulation of chromatin binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] subset: gocheck_do_not_annotate is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003682 ! negatively regulates chromatin binding relationship: RO:0002212 GO:0003682 ! negatively regulates chromatin binding creation_date: 2010-05-19T10:29:06Z [Term] id: GO:0035563 name: positive regulation of chromatin binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] subset: gocheck_do_not_annotate is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003682 ! positively regulates chromatin binding relationship: RO:0002213 GO:0003682 ! positively regulates chromatin binding creation_date: 2010-05-19T10:29:41Z [Term] id: GO:0035577 name: azurophil granule membrane namespace: cellular_component def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] synonym: "primary granule membrane" EXACT [] is_a: GO:0005765 ! lysosomal membrane is_a: GO:0030667 ! secretory granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0042582 ! bounding layer of azurophil granule relationship: RO:0002007 GO:0042582 ! bounding layer of azurophil granule creation_date: 2010-10-05T01:29:10Z [Term] id: GO:0035592 name: establishment of protein localization to extracellular region namespace: biological_process def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] synonym: "establishment of protein localization in extracellular region" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071692 ! protein localization to extracellular region intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region created_by: bf creation_date: 2010-11-09T10:25:08Z [Term] id: GO:0035694 name: mitochondrial protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228] synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf] synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf] xref: Reactome:R-HSA-9837999 "Mitochondrial protein degradation" is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0007005 ! part of mitochondrion organization relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2011-02-28T11:06:40Z [Term] id: GO:0035700 name: astrocyte chemotaxis namespace: biological_process def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471] is_a: GO:0043615 ! astrocyte cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000127 ! results in movement of astrocyte creation_date: 2011-02-28T03:17:52Z [Term] id: GO:0035701 name: hematopoietic stem cell migration namespace: biological_process def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092] synonym: "hemopoietic stem cell migration" EXACT [CL:0000037] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000037 ! results in movement of hematopoietic stem cell relationship: RO:0002565 CL:0000037 ! results in movement of hematopoietic stem cell creation_date: 2011-02-28T03:20:36Z [Term] id: GO:0035702 name: monocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000576 ! acts on population of monocyte relationship: RO:0012003 CL:0000576 ! acts on population of monocyte creation_date: 2011-03-02T11:32:57Z [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia] synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] synonym: "intraflagellar transport" BROAD [] synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] xref: Reactome:R-HSA-5620924 "Intraflagellar transport" is_a: GO:0042073 ! intraciliary transport intersection_of: GO:0042073 ! intraciliary transport intersection_of: BFO:0000050 GO:0060271 ! part of cilium assembly relationship: BFO:0000050 GO:0060271 ! part of cilium assembly creation_date: 2011-03-17T10:55:42Z [Term] id: GO:0035736 name: cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis creation_date: 2011-03-17T10:57:03Z [Term] id: GO:0035767 name: endothelial cell chemotaxis namespace: biological_process def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF] is_a: GO:0043542 ! endothelial cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell creation_date: 2011-03-31T04:31:37Z [Term] id: GO:0035779 name: angioblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf] synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566] is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell creation_date: 2011-04-04T11:10:38Z [Term] id: GO:0035855 name: megakaryocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk] synonym: "megakaryocyte cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000556 ! results in development of megakaryocyte relationship: BFO:0000050 GO:0030219 ! part of megakaryocyte differentiation relationship: RO:0002296 CL:0000556 ! results in development of megakaryocyte creation_date: 2011-05-13T01:28:06Z [Term] id: GO:0035869 name: ciliary transition zone namespace: cellular_component def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230] comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. synonym: "cilial transition zone" EXACT [] synonym: "cilium transition zone" EXACT [] synonym: "connecting cilium" RELATED [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005929 ! part of cilium creation_date: 2011-05-25T03:09:58Z [Term] id: GO:0035886 name: vascular associated smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] synonym: "vascular smooth muscle cell differentiation" EXACT [] synonym: "VSMC differentiation" EXACT [PMID:16151017] is_a: GO:0051145 ! smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell relationship: BFO:0000050 GO:0001944 ! part of vasculature development relationship: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell creation_date: 2011-06-08T11:23:52Z [Term] id: GO:0035887 name: aortic smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell relationship: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell creation_date: 2011-06-08T11:34:26Z [Term] id: GO:0035904 name: aorta development namespace: biological_process def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0060840 ! artery development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000947 ! results in development of aorta relationship: RO:0002296 UBERON:0000947 ! results in development of aorta creation_date: 2011-06-24T11:00:07Z [Term] id: GO:0035905 name: ascending aorta development namespace: biological_process def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001496 ! results in development of ascending aorta relationship: BFO:0000050 GO:0035904 ! part of aorta development relationship: RO:0002296 UBERON:0001496 ! results in development of ascending aorta creation_date: 2011-06-24T11:02:01Z [Term] id: GO:0035906 name: descending aorta development namespace: biological_process def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001514 ! results in development of descending aorta relationship: BFO:0000050 GO:0035904 ! part of aorta development relationship: RO:0002296 UBERON:0001514 ! results in development of descending aorta creation_date: 2011-06-24T11:05:22Z [Term] id: GO:0035907 name: dorsal aorta development namespace: biological_process def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035904 ! aorta development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta relationship: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta creation_date: 2011-06-24T11:07:01Z [Term] id: GO:0035909 name: aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta relationship: BFO:0000050 GO:0035904 ! part of aorta development relationship: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta creation_date: 2011-06-24T11:11:11Z [Term] id: GO:0035910 name: ascending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta relationship: BFO:0000050 GO:0035905 ! part of ascending aorta development relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis relationship: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta creation_date: 2011-06-24T11:14:52Z [Term] id: GO:0035911 name: descending aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta relationship: BFO:0000050 GO:0035906 ! part of descending aorta development relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis relationship: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta creation_date: 2011-06-24T11:19:24Z [Term] id: GO:0035912 name: dorsal aorta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] is_a: GO:0035909 ! aorta morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta relationship: BFO:0000050 GO:0035907 ! part of dorsal aorta development relationship: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta creation_date: 2011-06-24T11:22:14Z [Term] id: GO:0035914 name: skeletal muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle creation_date: 2011-06-24T02:36:19Z [Term] id: GO:0035927 name: RNA import into mitochondrion namespace: biological_process def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904] synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans] synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0050658 ! RNA transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2011-07-19T09:39:37Z [Term] id: GO:0035929 name: steroid hormone secretion namespace: biological_process def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl] is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:26764 ! has primary input relationship: RO:0004009 CHEBI:26764 ! has primary input creation_date: 2011-07-20T01:01:00Z [Term] id: GO:0035935 name: androgen secretion namespace: biological_process def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl] is_a: GO:0035929 ! steroid hormone secretion creation_date: 2011-07-20T01:11:31Z [Term] id: GO:0035981 name: tongue muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851] is_a: GO:0098528 ! skeletal muscle fiber differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002673 ! results in acquisition of features of tongue muscle cell relationship: RO:0002315 CL:0002673 ! results in acquisition of features of tongue muscle cell creation_date: 2011-08-22T01:35:16Z [Term] id: GO:0035987 name: endodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332] synonym: "endoderm cell differentiation" EXACT [CL:0000223] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell relationship: BFO:0000050 GO:0001706 ! part of endoderm formation relationship: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell creation_date: 2011-08-25T04:50:36Z [Term] id: GO:0035989 name: tendon development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043] synonym: "sinew development" RELATED [UBERON:0000043] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000043 ! results in development of tendon relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0000043 ! results in development of tendon creation_date: 2011-08-26T04:14:30Z [Term] id: GO:0035990 name: tendon cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429] synonym: "muscle attachment cell differentiation" EXACT [CL:0000388] synonym: "tenocyte differentiation" RELATED [CL:0000388] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000388 ! results in acquisition of features of tendon cell relationship: BFO:0000050 GO:0035992 ! part of tendon formation relationship: RO:0002315 CL:0000388 ! results in acquisition of features of tendon cell creation_date: 2011-08-26T04:16:06Z [Term] id: GO:0035992 name: tendon formation namespace: biological_process def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000043 ! results in formation of tendon relationship: BFO:0000050 GO:0035989 ! part of tendon development relationship: RO:0002297 UBERON:0000043 ! results in formation of tendon creation_date: 2011-08-30T01:35:10Z [Term] id: GO:0036035 name: osteoclast development namespace: biological_process def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf] synonym: "osteoclast cell development" EXACT [GOC:bf] is_a: GO:0061515 ! myeloid cell development is_a: GO:0098751 ! bone cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000092 ! results in development of osteoclast relationship: BFO:0000050 GO:0030316 ! part of osteoclast differentiation relationship: RO:0002296 CL:0000092 ! results in development of osteoclast creation_date: 2011-11-02T05:20:35Z [Term] id: GO:0036072 name: direct ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034] is_a: GO:0001503 ! ossification creation_date: 2011-12-19T01:47:22Z [Term] id: GO:0036093 name: germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000586 ! acts on population of germ cell relationship: BFO:0000050 GO:0007276 ! part of gamete generation relationship: RO:0012003 CL:0000586 ! acts on population of germ cell creation_date: 2012-01-17T04:06:27Z [Term] id: GO:0036094 name: small molecule binding namespace: molecular_function def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon is_a: GO:0005488 ! binding created_by: bf creation_date: 2012-01-17T04:20:34Z [Term] id: GO:0036135 name: Schwann cell migration namespace: biological_process def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintenance and function." [CL:0002573, PMID:20335460] is_a: GO:0008347 ! glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002573 ! results in movement of Schwann cell relationship: RO:0002565 CL:0002573 ! results in movement of Schwann cell creation_date: 2012-03-06T10:44:39Z [Term] id: GO:0036145 name: dendritic cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316] synonym: "DC homeostasis" RELATED [PMID:19176316] is_a: GO:0001776 ! leukocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000451 ! acts on population of dendritic cell relationship: RO:0012003 CL:0000451 ! acts on population of dendritic cell creation_date: 2012-03-12T11:05:36Z [Term] id: GO:0036160 name: melanocyte-stimulating hormone secretion namespace: biological_process def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone] synonym: "MSH secretion" EXACT [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion creation_date: 2012-03-26T01:16:55Z [Term] id: GO:0036179 name: osteoclast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg] synonym: "chondroclast maturation" RELATED [CL:0000092] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000092 ! results in maturation of osteoclast relationship: BFO:0000050 GO:0036035 ! part of osteoclast development relationship: RO:0002299 CL:0000092 ! results in maturation of osteoclast creation_date: 2012-03-29T02:04:00Z [Term] id: GO:0036194 name: muscle cell projection namespace: cellular_component def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] synonym: "muscle arm" NARROW [GOC:kmv] synonym: "myocyte projection" EXACT [CL:0000187] synonym: "myopodia" NARROW [GOC:kmv] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 CL:0000187 ! part of muscle cell creation_date: 2012-04-20T10:20:47Z [Term] id: GO:0036195 name: muscle cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] is_a: GO:0031253 ! cell projection membrane intersection_of: GO:0031253 ! cell projection membrane intersection_of: BFO:0000050 GO:0036194 ! part of muscle cell projection relationship: BFO:0000050 GO:0036194 ! part of muscle cell projection creation_date: 2012-04-20T10:21:51Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process alt_id: GO:0006464 def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_prokaryote synonym: "cellular protein modification process" EXACT [] synonym: "process resulting in protein modification" EXACT [] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification created_by: bf creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0036230 name: granulocyte activation namespace: biological_process def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000094 ! has primary input granulocyte relationship: RO:0004009 CL:0000094 ! has primary input granulocyte creation_date: 2012-05-11T10:57:48Z [Term] id: GO:0036293 name: response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. synonym: "response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0070482 ! response to oxygen levels creation_date: 2012-07-20T01:05:46Z [Term] id: GO:0036334 name: epidermal stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529] is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis relationship: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis creation_date: 2012-09-05T10:21:23Z [Term] id: GO:0036336 name: dendritic cell migration namespace: biological_process def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990] is_a: GO:0071674 ! mononuclear cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell relationship: RO:0002565 CL:0000451 ! results in movement of dendritic cell creation_date: 2012-09-05T10:24:46Z [Term] id: GO:0036477 name: somatodendritic compartment namespace: cellular_component def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa creation_date: 2014-07-24T10:06:19Z [Term] id: GO:0036484 name: trunk neural crest cell migration namespace: biological_process def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238] synonym: "trunk NCC migration" EXACT [PMID:2387238] is_a: GO:0001755 ! neural crest cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000011 ! results in movement of migratory trunk neural crest cell relationship: BFO:0000050 GO:0035290 ! part of trunk segmentation relationship: RO:0002565 CL:0000011 ! results in movement of migratory trunk neural crest cell creation_date: 2014-08-26T15:27:44Z [Term] id: GO:0036504 name: Golgi membrane fusion namespace: biological_process def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691] synonym: "Golgi apparatus membrane fusion" EXACT [] synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf] synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609] is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane relationship: BFO:0000050 GO:0090168 ! part of Golgi reassembly relationship: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane creation_date: 2015-05-21T10:05:06Z [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_plant_ribbon synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] synonym: "signalling receptor activity" EXACT [] is_a: GO:0060089 ! molecular transducer activity creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0038161 name: prolactin signaling pathway namespace: biological_process def: "The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429] synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246] synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0019221 ! cytokine-mediated signaling pathway creation_date: 2012-05-14T01:52:59Z [Term] id: GO:0038187 name: pattern recognition receptor activity namespace: molecular_function def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response." [GOC:ar, GOC:bf] synonym: "macrophage receptor activity" RELATED [] synonym: "MAMP receptor activity" NARROW [] synonym: "microbe-associated molecular pattern receptor activity" NARROW [] synonym: "PAMP receptor activity" NARROW [] synonym: "pathogen associated molecular pattern receptor activity" NARROW [] synonym: "PRR" EXACT [] synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor] synonym: "signaling pattern recognition receptor activity" RELATED [] xref: Wikipedia:Pattern_recognition_receptor is_a: GO:0038023 ! signaling receptor activity creation_date: 2013-05-29T15:24:44Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0040007 ! regulates growth relationship: RO:0002211 GO:0040007 ! regulates growth [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0040012 name: regulation of locomotion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0040011 ! regulates locomotion relationship: RO:0002211 GO:0040011 ! regulates locomotion [Term] id: GO:0040013 name: negative regulation of locomotion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "down regulation of locomotion" EXACT [] synonym: "down-regulation of locomotion" EXACT [] synonym: "downregulation of locomotion" EXACT [] synonym: "inhibition of locomotion" NARROW [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0040011 ! negatively regulates locomotion relationship: RO:0002212 GO:0040011 ! negatively regulates locomotion [Term] id: GO:0040014 name: regulation of multicellular organism growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035264 ! regulates multicellular organism growth relationship: RO:0002211 GO:0035264 ! regulates multicellular organism growth [Term] id: GO:0040015 name: negative regulation of multicellular organism growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth relationship: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth [Term] id: GO:0040016 name: embryonic cleavage namespace: biological_process def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] is_a: GO:0051301 ! cell division relationship: BFO:0000050 GO:0009790 ! part of embryo development [Term] id: GO:0040017 name: positive regulation of locomotion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] synonym: "activation of locomotion" NARROW [] synonym: "stimulation of locomotion" NARROW [] synonym: "up regulation of locomotion" EXACT [] synonym: "up-regulation of locomotion" EXACT [] synonym: "upregulation of locomotion" EXACT [] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0040011 ! positively regulates locomotion relationship: RO:0002213 GO:0040011 ! positively regulates locomotion [Term] id: GO:0040018 name: positive regulation of multicellular organism growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] is_a: GO:0040014 ! regulation of multicellular organism growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth relationship: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth [Term] id: GO:0040019 name: positive regulation of embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "activation of embryonic development" NARROW [] synonym: "stimulation of embryonic development" NARROW [] synonym: "up regulation of embryonic development" EXACT [] synonym: "up-regulation of embryonic development" EXACT [] synonym: "upregulation of embryonic development" EXACT [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009790 ! positively regulates embryo development relationship: RO:0002213 GO:0009790 ! positively regulates embryo development [Term] id: GO:0040020 name: regulation of meiotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] synonym: "regulation of meiosis" BROAD [GOC:vw] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140013 ! regulates meiotic nuclear division relationship: RO:0002211 GO:0140013 ! regulates meiotic nuclear division [Term] id: GO:0040034 name: regulation of development, heterochronic namespace: biological_process def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] synonym: "developmental timing" RELATED [] synonym: "heterochronic regulation of development" EXACT [] synonym: "temporal regulation of development" EXACT [] is_a: GO:0050793 ! regulation of developmental process [Term] id: GO:0042063 name: gliogenesis namespace: biological_process def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] is_a: GO:0022008 ! neurogenesis intersection_of: GO:0008150 ! biological_process intersection_of: RO:0002297 CL:0000125 ! results in formation of glial cell relationship: RO:0002297 CL:0000125 ! results in formation of glial cell [Term] id: GO:0042065 name: glial cell growth namespace: biological_process def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 CL:0000125 ! results in growth of glial cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0002343 CL:0000125 ! results in growth of glial cell [Term] id: GO:0042069 name: regulation of catecholamine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] synonym: "regulation of catecholamine metabolism" EXACT [] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process relationship: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process [Term] id: GO:0042073 name: intraciliary transport namespace: biological_process def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "IFT" RELATED [] synonym: "intraflagellar transport" EXACT [] synonym: "intraflagellar transport involved in cilium organization" EXACT [] synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] xref: Wikipedia:Intraflagellar_transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005929 ! occurs in cilium intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: BFO:0000050 GO:0044782 ! part of cilium organization relationship: BFO:0000066 GO:0005929 ! occurs in cilium [Term] id: GO:0042074 name: cell migration involved in gastrulation namespace: biological_process def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, PMID:16099638] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation relationship: BFO:0000050 GO:0007369 ! part of gastrulation [Term] id: GO:0042078 name: germ-line stem cell division namespace: biological_process def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] synonym: "germ-line stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell relationship: BFO:0000050 GO:0007281 ! part of germ cell development relationship: RO:0004009 CL:0000014 ! has primary input germ line stem cell [Term] id: GO:0042098 name: T cell proliferation namespace: biological_process def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl] synonym: "T lymphocyte proliferation" EXACT [] synonym: "T-cell proliferation" EXACT [] synonym: "T-lymphocyte proliferation" EXACT [] is_a: GO:0042110 ! T cell activation is_a: GO:0046651 ! lymphocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell relationship: RO:0012003 CL:0000084 ! acts on population of T cell [Term] id: GO:0042102 name: positive regulation of T cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai] synonym: "activation of T cell proliferation" NARROW [] synonym: "positive regulation of T lymphocyte proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte proliferation" EXACT [] synonym: "stimulation of T cell proliferation" NARROW [] synonym: "up regulation of T cell proliferation" EXACT [] synonym: "up-regulation of T cell proliferation" EXACT [] synonym: "upregulation of T cell proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042098 ! positively regulates T cell proliferation relationship: RO:0002213 GO:0042098 ! positively regulates T cell proliferation [Term] id: GO:0042103 name: positive regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl] synonym: "activation of T cell homeostatic proliferation" NARROW [] synonym: "positive regulation of resting T cell proliferation" EXACT [] synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "positive regulation of T-cell homeostatic proliferation" EXACT [] synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT [] synonym: "stimulation of T cell homeostatic proliferation" NARROW [] synonym: "up regulation of T cell homeostatic proliferation" EXACT [] synonym: "up-regulation of T cell homeostatic proliferation" EXACT [] synonym: "upregulation of T cell homeostatic proliferation" EXACT [] is_a: GO:0042102 ! positive regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001777 ! positively regulates T cell homeostatic proliferation relationship: RO:0002213 GO:0001777 ! positively regulates T cell homeostatic proliferation [Term] id: GO:0042110 name: T cell activation namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] synonym: "T lymphocyte activation" EXACT [] synonym: "T-cell activation" EXACT [] synonym: "T-lymphocyte activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000084 ! has primary input T cell relationship: RO:0004009 CL:0000084 ! has primary input T cell [Term] id: GO:0042116 name: macrophage activation namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] synonym: "macrophage polarization" EXACT [] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000235 ! has primary input macrophage relationship: RO:0004009 CL:0000235 ! has primary input macrophage [Term] id: GO:0042117 name: monocyte activation namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000576 ! has primary input monocyte relationship: RO:0004009 CL:0000576 ! has primary input monocyte [Term] id: GO:0042118 name: endothelial cell activation namespace: biological_process def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484] is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000115 ! has primary input endothelial cell relationship: RO:0004009 CL:0000115 ! has primary input endothelial cell [Term] id: GO:0042127 name: regulation of cell population proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] synonym: "regulation of cell proliferation" RELATED [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008283 ! regulates cell population proliferation relationship: RO:0002211 GO:0008283 ! regulates cell population proliferation [Term] id: GO:0042129 name: regulation of T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl] synonym: "regulation of T lymphocyte proliferation" EXACT [] synonym: "regulation of T-cell proliferation" EXACT [] synonym: "regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042098 ! regulates T cell proliferation relationship: RO:0002211 GO:0042098 ! regulates T cell proliferation [Term] id: GO:0042130 name: negative regulation of T cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl] synonym: "down regulation of T cell proliferation" EXACT [] synonym: "down-regulation of T cell proliferation" EXACT [] synonym: "downregulation of T cell proliferation" EXACT [] synonym: "inhibition of T cell proliferation" NARROW [] synonym: "negative regulation of T lymphocyte proliferation" EXACT [] synonym: "negative regulation of T-cell proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042098 ! negatively regulates T cell proliferation relationship: RO:0002212 GO:0042098 ! negatively regulates T cell proliferation [Term] id: GO:0042166 name: acetylcholine binding namespace: molecular_function def: "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input [Term] id: GO:0042170 name: plastid membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0009526 ! part of plastid envelope [Term] id: GO:0042173 name: regulation of sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl] is_a: GO:0043937 ! regulation of sporulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030435 ! regulates sporulation resulting in formation of a cellular spore relationship: RO:0002211 GO:0030435 ! regulates sporulation resulting in formation of a cellular spore [Term] id: GO:0042175 name: nuclear outer membrane-endoplasmic reticulum membrane network namespace: cellular_component def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "NE-ER continuum" RELATED [] synonym: "NE-ER network" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] synonym: "nuclear envelope-ER network" RELATED [] synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process" EXACT [] synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "regulation of cyclin catabolic process" NARROW [] synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "regulation of cyclin degradation" NARROW [GOC:obol] synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030163 ! regulates protein catabolic process relationship: RO:0002211 GO:0030163 ! regulates protein catabolic process creation_date: 2014-08-21T15:05:45Z [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process" EXACT [] synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process relationship: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process [Term] id: GO:0042180 name: ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir synonym: "ketone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0042181 name: ketone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] synonym: "ketone anabolism" EXACT [] synonym: "ketone biosynthesis" EXACT [] synonym: "ketone formation" EXACT [] synonym: "ketone synthesis" EXACT [] is_a: GO:0042180 ! ketone metabolic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_plant subset: goslim_plant_ribbon subset: goslim_yeast synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:24431 ! has primary input chemical entity relationship: RO:0004009 CHEBI:24431 ! has primary input chemical entity [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0042255 name: ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428] subset: goslim_yeast synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw] is_a: GO:0140694 ! membraneless organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005840 ! results in assembly of ribosome relationship: BFO:0000050 GO:0042254 ! part of ribosome biogenesis relationship: RO:0002588 GO:0005840 ! results in assembly of ribosome [Term] id: GO:0042268 name: regulation of cytolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, GOC:mtg_apoptosis] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019835 ! regulates cytolysis relationship: RO:0002211 GO:0019835 ! regulates cytolysis [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0042306 name: regulation of protein import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] synonym: "regulation of protein import into cell nucleus" EXACT [] synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of protein-nucleus import" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006606 ! regulates protein import into nucleus relationship: RO:0002211 GO:0006606 ! regulates protein import into nucleus [Term] id: GO:0042307 name: positive regulation of protein import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "activation of protein import into nucleus" NARROW [] synonym: "positive regulation of protein import into cell nucleus" EXACT [] synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of protein-nucleus import" EXACT [] synonym: "stimulation of protein import into nucleus" NARROW [] synonym: "up regulation of protein import into nucleus" EXACT [] synonym: "up-regulation of protein import into nucleus" EXACT [] synonym: "upregulation of protein import into nucleus" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1900182 ! positive regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006606 ! positively regulates protein import into nucleus relationship: RO:0002213 GO:0006606 ! positively regulates protein import into nucleus [Term] id: GO:0042308 name: negative regulation of protein import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] synonym: "down regulation of protein import into nucleus" EXACT [] synonym: "down-regulation of protein import into nucleus" EXACT [] synonym: "downregulation of protein import into nucleus" EXACT [] synonym: "inhibition of protein import into nucleus" NARROW [] synonym: "negative regulation of protein import into cell nucleus" EXACT [] synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of protein-nucleus import" EXACT [] is_a: GO:0042306 ! regulation of protein import into nucleus is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1900181 ! negative regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006606 ! negatively regulates protein import into nucleus relationship: RO:0002212 GO:0006606 ! negatively regulates protein import into nucleus [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_obsoletion_candidate is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016310 ! regulates phosphorylation relationship: RO:0002211 GO:0016310 ! regulates phosphorylation [Term] id: GO:0042326 name: negative regulation of phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_obsoletion_candidate synonym: "down regulation of phosphorylation" EXACT [] synonym: "down-regulation of phosphorylation" EXACT [] synonym: "downregulation of phosphorylation" EXACT [] synonym: "inhibition of phosphorylation" NARROW [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045936 ! negative regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016310 ! negatively regulates phosphorylation relationship: RO:0002212 GO:0016310 ! negatively regulates phosphorylation [Term] id: GO:0042327 name: positive regulation of phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] synonym: "activation of phosphorylation" NARROW [] synonym: "stimulation of phosphorylation" NARROW [] synonym: "up regulation of phosphorylation" EXACT [] synonym: "up-regulation of phosphorylation" EXACT [] synonym: "upregulation of phosphorylation" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0045937 ! positive regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016310 ! positively regulates phosphorylation relationship: RO:0002213 GO:0016310 ! positively regulates phosphorylation [Term] id: GO:0042330 name: taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] synonym: "directed movement in response to stimulus" EXACT [] xref: Wikipedia:Taxis is_a: GO:0040011 ! locomotion relationship: BFO:0000050 GO:0009605 ! part of response to external stimulus [Term] id: GO:0042379 name: chemokine receptor binding namespace: molecular_function def: "Binding to a chemokine receptor." [GOC:ai] synonym: "chemokine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0005126 ! cytokine receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001128 ! has primary input chemokine receptor relationship: RO:0004009 PR:000001128 ! has primary input chemokine receptor [Term] id: GO:0042391 name: regulation of membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] is_a: GO:0065008 ! regulation of biological quality relationship: BFO:0000051 GO:0034220 ! has part monoatomic ion transmembrane transport [Term] id: GO:0042401 name: biogenic amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine anabolism" EXACT [] synonym: "biogenic amine biosynthesis" EXACT [] synonym: "biogenic amine formation" EXACT [] synonym: "biogenic amine synthesis" EXACT [] synonym: "cellular biogenic amine biosynthetic process" EXACT [] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009309 ! amine biosynthetic process [Term] id: GO:0042402 name: biogenic amine catabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732] synonym: "biogenic amine breakdown" EXACT [] synonym: "biogenic amine catabolism" EXACT [] synonym: "biogenic amine degradation" EXACT [] is_a: GO:0009310 ! amine catabolic process [Term] id: GO:0042415 name: norepinephrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol metabolic process" EXACT [] synonym: "levarterenol metabolism" EXACT [] synonym: "noradrenaline metabolic process" EXACT [] synonym: "noradrenaline metabolism" EXACT [] synonym: "norepinephrine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:72587 ! has primary input or output relationship: RO:0004007 CHEBI:72587 ! has primary input or output [Term] id: GO:0042421 name: norepinephrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol biosynthesis" EXACT [] synonym: "levarterenol biosynthetic process" EXACT [] synonym: "noradrenaline biosynthesis" EXACT [] synonym: "noradrenaline biosynthetic process" EXACT [] synonym: "norepinephrine anabolism" EXACT [] synonym: "norepinephrine biosynthesis" EXACT [] synonym: "norepinephrine formation" EXACT [] synonym: "norepinephrine synthesis" EXACT [] is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042423 ! catecholamine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:72587 ! has primary output relationship: RO:0004008 CHEBI:72587 ! has primary output [Term] id: GO:0042422 name: norepinephrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] synonym: "levarterenol catabolic process" EXACT [] synonym: "levarterenol catabolism" EXACT [] synonym: "noradrenaline catabolic process" EXACT [] synonym: "noradrenaline catabolism" EXACT [] synonym: "norepinephrine breakdown" EXACT [] synonym: "norepinephrine catabolism" EXACT [] synonym: "norepinephrine degradation" EXACT [] xref: Wikipedia:Norepinephrine#Degradation is_a: GO:0042415 ! norepinephrine metabolic process is_a: GO:0042424 ! catecholamine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0042423 name: catecholamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine anabolism" EXACT [] synonym: "catecholamine biosynthesis" EXACT [] synonym: "catecholamine formation" EXACT [] synonym: "catecholamine synthesis" EXACT [] xref: Reactome:R-HSA-209905 "Catecholamine biosynthesis" xref: Wikipedia:Catecholamines is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0042401 ! biogenic amine biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33567 ! has primary output relationship: RO:0004008 CHEBI:33567 ! has primary output [Term] id: GO:0042424 name: catecholamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine breakdown" EXACT [] synonym: "catecholamine catabolism" EXACT [] synonym: "catecholamine degradation" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042402 ! biogenic amine catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input [Term] id: GO:0042427 name: serotonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin anabolism" EXACT [] synonym: "serotonin biosynthesis" EXACT [] synonym: "serotonin formation" EXACT [] synonym: "serotonin synthesis" EXACT [] xref: Wikipedia:Serotonin is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:350546 ! has primary output relationship: RO:0004008 CHEBI:350546 ! has primary output [Term] id: GO:0042428 name: serotonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:350546 ! has primary input or output relationship: RO:0004007 CHEBI:350546 ! has primary input or output [Term] id: GO:0042429 name: serotonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin breakdown" EXACT [] synonym: "serotonin catabolism" EXACT [] synonym: "serotonin degradation" EXACT [] xref: Reactome:R-HSA-380612 "Metabolism of serotonin" is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:1901161 ! primary amino compound catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0042430 name: indole-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah] synonym: "indole and derivative metabolic process" EXACT [] synonym: "indole and derivative metabolism" EXACT [] synonym: "indole derivative metabolic process" NARROW [] synonym: "indole derivative metabolism" NARROW [] synonym: "indole-containing compound metabolism" EXACT [] synonym: "ketole metabolic process" EXACT [] synonym: "ketole metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:24828 ! has primary input or output indoles relationship: RO:0004007 CHEBI:24828 ! has primary input or output indoles [Term] id: GO:0042435 name: indole-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative biosynthesis" EXACT [] synonym: "indole derivative biosynthetic process" EXACT [] synonym: "indole-containing compound anabolism" EXACT [] synonym: "indole-containing compound biosynthesis" EXACT [] synonym: "indole-containing compound formation" EXACT [] synonym: "indole-containing compound synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:24828 ! has primary output indoles relationship: RO:0004008 CHEBI:24828 ! has primary output indoles [Term] id: GO:0042436 name: indole-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] synonym: "indole derivative catabolic process" EXACT [] synonym: "indole derivative catabolism" EXACT [] synonym: "indole-containing compound breakdown" EXACT [] synonym: "indole-containing compound catabolism" EXACT [] synonym: "indole-containing compound degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042430 ! indole-containing compound metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:24828 ! has primary input indoles relationship: RO:0004009 CHEBI:24828 ! has primary input indoles [Term] id: GO:0042442 name: melatonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl] synonym: "melatonin breakdown" EXACT [] synonym: "melatonin catabolism" EXACT [] synonym: "melatonin degradation" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0042447 ! hormone catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:16796 ! has primary input relationship: RO:0004009 CHEBI:16796 ! has primary input [Term] id: GO:0042445 name: hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] subset: goslim_pir synonym: "cellular hormone metabolic process" RELATED [] synonym: "hormone metabolism" EXACT [] is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0042446 name: hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] synonym: "hormone anabolism" EXACT [] synonym: "hormone biosynthesis" EXACT [] synonym: "hormone formation" EXACT [] synonym: "hormone synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042447 name: hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] synonym: "hormone breakdown" EXACT [] synonym: "hormone catabolism" EXACT [] synonym: "hormone degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0042461 name: photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] synonym: "photoreceptor morphogenesis" EXACT [] is_a: GO:0048666 ! neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000210 ! results in development of photoreceptor cell relationship: BFO:0000050 GO:0046530 ! part of photoreceptor cell differentiation relationship: RO:0002296 CL:0000210 ! results in development of photoreceptor cell [Term] id: GO:0042462 name: eye photoreceptor cell development namespace: biological_process def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] is_a: GO:0042461 ! photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell relationship: BFO:0000050 GO:0001754 ! part of eye photoreceptor cell differentiation relationship: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell [Term] id: GO:0042478 name: regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "regulation of eye photoreceptor development" EXACT [] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development relationship: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development [Term] id: GO:0042479 name: positive regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "activation of eye photoreceptor cell development" NARROW [] synonym: "positive regulation of eye photoreceptor development" EXACT [] synonym: "stimulation of eye photoreceptor cell development" NARROW [] synonym: "up regulation of eye photoreceptor cell development" EXACT [] synonym: "up-regulation of eye photoreceptor cell development" EXACT [] synonym: "upregulation of eye photoreceptor cell development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development relationship: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development [Term] id: GO:0042480 name: negative regulation of eye photoreceptor cell development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] synonym: "down regulation of eye photoreceptor cell development" EXACT [] synonym: "down-regulation of eye photoreceptor cell development" EXACT [] synonym: "downregulation of eye photoreceptor cell development" EXACT [] synonym: "inhibition of eye photoreceptor cell development" NARROW [] synonym: "negative regulation of eye photoreceptor development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0042478 ! regulation of eye photoreceptor cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development relationship: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development [Term] id: GO:0042551 name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000540 ! results in maturation of neuron relationship: BFO:0000050 GO:0048666 ! part of neuron development relationship: RO:0002299 CL:0000540 ! results in maturation of neuron [Term] id: GO:0042552 name: myelination namespace: biological_process def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah] synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429] xref: Wikipedia:Myelin is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0042562 name: hormone binding namespace: molecular_function def: "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0042582 name: azurophil granule namespace: cellular_component def: "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule] synonym: "primary granule" EXACT [] is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! secretory granule [Term] id: GO:0042592 name: homeostatic process namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_agr subset: goslim_chembl subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042611 name: MHC protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240] subset: goslim_pir is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0042613 name: MHC class II protein complex namespace: cellular_component def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0042641 name: actomyosin namespace: cellular_component def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] synonym: "actomyosin complex" EXACT [] synonym: "actomyosin structure" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton [Term] id: GO:0042644 name: chloroplast nucleoid namespace: cellular_component def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] is_a: GO:0042646 ! plastid nucleoid intersection_of: GO:0009295 ! nucleoid intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma [Term] id: GO:0042645 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular membraneless organelle intersection_of: GO:0009295 ! nucleoid intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0005759 ! part of mitochondrial matrix [Term] id: GO:0042646 name: plastid nucleoid namespace: cellular_component def: "The region of a plastid to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular membraneless organelle intersection_of: GO:0009295 ! nucleoid intersection_of: BFO:0000050 GO:0009536 ! part of plastid relationship: BFO:0000050 GO:0009532 ! part of plastid stroma [Term] id: GO:0042648 name: chloroplast chromosome namespace: cellular_component def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] is_a: GO:0009508 ! plastid chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0042644 ! part of chloroplast nucleoid [Term] id: GO:0042670 name: retinal cone cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell relationship: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell [Term] id: GO:0042692 name: muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] synonym: "myogenesis" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell relationship: BFO:0000050 GO:0061061 ! part of muscle structure development relationship: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide relationship: RO:0004009 CHEBI:32988 ! has primary input amide [Term] id: GO:0042887 name: amide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] synonym: "amine/amide/polyamine channel activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide relationship: BFO:0000050 GO:0042886 ! part of amide transport relationship: RO:0004009 CHEBI:32988 ! has primary input amide [Term] id: GO:0042923 name: neuropeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [PMID:10414961, PMID:38337033] is_a: GO:0042277 ! peptide binding [Term] id: GO:0042981 name: regulation of apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "apoptosis regulator activity" RELATED [] synonym: "regulation of apoptosis" NARROW [] xref: Reactome:R-HSA-169911 "Regulation of Apoptosis" xref: Reactome:R-HSA-5633008 "TP53 Regulates Transcription of Cell Death Genes" is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006915 ! regulates apoptotic process relationship: RO:0002211 GO:0006915 ! regulates apoptotic process [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917] subset: goslim_agr subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0042996 name: regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] is_a: GO:0051223 ! regulation of protein transport is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903076 ! regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport relationship: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport [Term] id: GO:0042997 name: negative regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport relationship: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport [Term] id: GO:0042998 name: positive regulation of Golgi to plasma membrane protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport relationship: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport [Term] id: GO:0043001 name: Golgi to plasma membrane protein transport namespace: biological_process def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] is_a: GO:0006893 ! Golgi to plasma membrane transport is_a: GO:0015031 ! protein transport is_a: GO:0061951 ! establishment of protein localization to plasma membrane intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle [Term] id: GO:0043005 name: neuron projection namespace: cellular_component def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060] subset: goslim_pir synonym: "nerve fiber" RELATED [GOC:dph] synonym: "neurite" NARROW [] synonym: "neuron process" EXACT [] synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889] synonym: "neuronal cell projection" EXACT [] xref: NIF_Subcellular:sao867568886 is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0043009 name: chordate embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: GO:0043010 name: camera-type eye development namespace: biological_process def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001654 ! eye development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000019 ! results in development of camera-type eye relationship: RO:0002296 UBERON:0000019 ! results in development of camera-type eye [Term] id: GO:0043011 name: myeloid dendritic cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl] xref: Wikipedia:Dendritic_cell is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:0097028 ! dendritic cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000782 ! results in acquisition of features of myeloid dendritic cell relationship: RO:0002315 CL:0000782 ! results in acquisition of features of myeloid dendritic cell [Term] id: GO:0043021 name: ribonucleoprotein complex binding namespace: molecular_function def: "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] subset: goslim_pir synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk] synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk] synonym: "RNP binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex relationship: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex [Term] id: GO:0043022 name: ribosome binding namespace: molecular_function def: "Binding to a ribosome." [GOC:go_curators] synonym: "ribosome receptor activity" NARROW [] is_a: GO:0043021 ! ribonucleoprotein complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome relationship: RO:0004009 GO:0005840 ! has primary input ribosome [Term] id: GO:0043025 name: neuronal cell body namespace: cellular_component def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. subset: goslim_pir synonym: "neuron cell body" EXACT [] synonym: "neuronal cell soma" EXACT [] xref: NIF_Subcellular:sao1044911821 xref: Wikipedia:Soma_(biology) is_a: GO:0044297 ! cell body intersection_of: GO:0044297 ! cell body intersection_of: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 GO:0036477 ! part of somatodendritic compartment [Term] id: GO:0043029 name: T cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149] comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "T lymphocyte homeostasis" EXACT [] synonym: "T-cell homeostasis" EXACT [] synonym: "T-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell relationship: RO:0012003 CL:0000084 ! acts on population of T cell [Term] id: GO:0043030 name: regulation of macrophage activation namespace: biological_process def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] synonym: "regulation of macrophage polarization" EXACT [] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042116 ! regulates macrophage activation relationship: RO:0002211 GO:0042116 ! regulates macrophage activation [Term] id: GO:0043031 name: negative regulation of macrophage activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] synonym: "down regulation of macrophage activation" EXACT [] synonym: "down-regulation of macrophage activation" EXACT [] synonym: "downregulation of macrophage activation" EXACT [] synonym: "inhibition of macrophage activation" NARROW [] synonym: "negative regulation of macrophage polarization" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042116 ! negatively regulates macrophage activation relationship: RO:0002212 GO:0042116 ! negatively regulates macrophage activation [Term] id: GO:0043032 name: positive regulation of macrophage activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] synonym: "activation of macrophage activation" NARROW [] synonym: "positive regulation of macrophage polarization" EXACT [] synonym: "stimulation of macrophage activation" NARROW [] synonym: "up regulation of macrophage activation" EXACT [] synonym: "up-regulation of macrophage activation" EXACT [] synonym: "upregulation of macrophage activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0043030 ! regulation of macrophage activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042116 ! positively regulates macrophage activation relationship: RO:0002213 GO:0042116 ! positively regulates macrophage activation [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl] synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] xref: Reactome:R-HSA-9037628 "Rhesus blood group biosynthesis" is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:60466 ! has primary output peptide zwitterion relationship: RO:0004008 CHEBI:60466 ! has primary output peptide zwitterion [Term] id: GO:0043062 name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: goslim_prokaryote synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005576 ! results in organization of extracellular region relationship: RO:0002592 GO:0005576 ! results in organization of extracellular region [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] xref: Reactome:R-HSA-193648 "NRAGE signals death through JNK" xref: Reactome:R-HSA-205043 "NRIF signals cell death from the nucleus" is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043068 ! positive regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006915 ! positively regulates apoptotic process relationship: RO:0002213 GO:0006915 ! positively regulates apoptotic process [Term] id: GO:0043066 name: negative regulation of apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. synonym: "anti-apoptosis" EXACT [] synonym: "apoptosis inhibitor activity" RELATED [] synonym: "down regulation of apoptosis" EXACT [] synonym: "down-regulation of apoptosis" EXACT [] synonym: "downregulation of apoptosis" EXACT [] synonym: "inhibition of apoptosis" NARROW [] synonym: "negative regulation of apoptosis" NARROW [] synonym: "pro-survival" RELATED [] xref: Reactome:R-HSA-193639 "p75NTR signals via NF-kB" xref: Reactome:R-HSA-211728 "Regulation of PAK-2p34 activity by PS-GAP/RHG10" xref: Reactome:R-HSA-211733 "Regulation of activated PAK-2p34 by proteasome mediated degradation" is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0043069 ! negative regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006915 ! negatively regulates apoptotic process relationship: RO:0002212 GO:0006915 ! negatively regulates apoptotic process [Term] id: GO:0043067 name: regulation of programmed cell death namespace: biological_process alt_id: GO:0043070 def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0012501 ! regulates programmed cell death relationship: RO:0002211 GO:0012501 ! regulates programmed cell death [Term] id: GO:0043068 name: positive regulation of programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "activation of programmed cell death" NARROW [] synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] synonym: "stimulation of programmed cell death" NARROW [] synonym: "up regulation of programmed cell death" EXACT [] synonym: "up-regulation of programmed cell death" EXACT [] synonym: "upregulation of programmed cell death" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0012501 ! positively regulates programmed cell death relationship: RO:0002213 GO:0012501 ! positively regulates programmed cell death [Term] id: GO:0043069 name: negative regulation of programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] synonym: "down regulation of programmed cell death" EXACT [] synonym: "down-regulation of programmed cell death" EXACT [] synonym: "downregulation of programmed cell death" EXACT [] synonym: "inhibition of programmed cell death" NARROW [] synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0012501 ! negatively regulates programmed cell death relationship: RO:0002212 GO:0012501 ! negatively regulates programmed cell death [Term] id: GO:0043073 name: germ cell nucleus namespace: cellular_component def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] synonym: "germ-cell nucleus" EXACT [] is_a: GO:0005634 ! nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000586 ! part of germ cell relationship: BFO:0000050 CL:0000586 ! part of germ cell [Term] id: GO:0043083 name: synaptic cleft namespace: cellular_component def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, PMID:30784960] subset: goslim_synapse xref: NIF_Subcellular:sao243541954 is_a: GO:0005576 ! extracellular region relationship: RO:0002220 GO:0045202 ! adjacent to synapse [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: gocheck_obsoletion_candidate subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003824 ! positively regulates catalytic activity relationship: RO:0002213 GO:0003824 ! positively regulates catalytic activity [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: gocheck_obsoletion_candidate synonym: "down regulation of enzyme activity" EXACT [] synonym: "down regulation of metalloenzyme activity" NARROW [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "down-regulation of metalloenzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "downregulation of metalloenzyme activity" NARROW [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "inhibition of metalloenzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] synonym: "negative regulation of metalloenzyme activity" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003824 ! negatively regulates catalytic activity relationship: RO:0002212 GO:0003824 ! negatively regulates catalytic activity [Term] id: GO:0043143 name: regulation of translation by machinery localization namespace: biological_process def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] synonym: "establishment and maintenance of translational machinery localization" EXACT [] synonym: "establishment and maintenance of translational protein localization" EXACT [] synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] synonym: "translational protein localization" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: BFO:0000050 GO:0006412 ! part of translation relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "atom binding" RELATED [] is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:24870 ! has primary input ion relationship: RO:0004009 CHEBI:24870 ! has primary input ion [Term] id: GO:0043168 name: anion binding namespace: molecular_function def: "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] is_a: GO:0043167 ! ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:22563 ! has primary input anion relationship: RO:0004009 CHEBI:22563 ! has primary input anion [Term] id: GO:0043169 name: cation binding namespace: molecular_function def: "Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl] is_a: GO:0043167 ! ion binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:36916 ! has primary input cation relationship: RO:0004009 CHEBI:36916 ! has primary input cation [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 alt_id: GO:0043283 alt_id: GO:0044259 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] synonym: "multicellular organismal macromolecule metabolic process" NARROW [] synonym: "organismal macromolecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33694 ! has primary input or output biomacromolecule relationship: RO:0004007 CHEBI:33694 ! has primary input or output biomacromolecule [Term] id: GO:0043171 name: peptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] synonym: "peptide breakdown" EXACT [] synonym: "peptide catabolism" EXACT [] synonym: "peptide degradation" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion [Term] id: GO:0043176 name: amine binding namespace: molecular_function def: "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group." [GOC:jl] subset: goslim_pir is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine relationship: RO:0004009 CHEBI:32952 ! has primary input amine [Term] id: GO:0043177 name: organic acid binding namespace: molecular_function def: "Binding to an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732] is_a: GO:0036094 ! small molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid [Term] id: GO:0043184 name: vascular endothelial growth factor receptor 2 binding namespace: molecular_function def: "Binding to a vascular endothelial growth factor receptor 2." [GOC:st] synonym: "Flk-1 binding" EXACT [] synonym: "KDR binding" BROAD [] synonym: "kinase domain region binding" EXACT [] synonym: "VEGF receptor 2 binding" EXACT [] synonym: "VEGFR 2 binding" EXACT [] is_a: GO:0005172 ! vascular endothelial growth factor receptor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000002112 ! has primary input vascular endothelial growth factor receptor 2 relationship: RO:0004009 PR:000002112 ! has primary input vascular endothelial growth factor receptor 2 [Term] id: GO:0043200 name: response to amino acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg] synonym: "response to amino acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion [Term] id: GO:0043207 name: response to external biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0043209 name: myelin sheath namespace: cellular_component def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin] synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204] synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730] synonym: "Schwann cell myelin sheath" NARROW [] xref: FMA:62983 xref: NIF_Subcellular:sao593830697 xref: Wikipedia:Myelin is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000125 ! part of glial cell [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical structure disjoint_from: GO:0044423 ! virion component [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: BFO:0000051 GO:0016020 ! has part membrane disjoint_from: GO:0043228 ! membraneless organelle relationship: BFO:0000051 GO:0016020 ! has part membrane [Term] id: GO:0043228 name: membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_mouse synonym: "biological condensate" RELATED [] synonym: "membrane-less organelle" EXACT [] synonym: "non-membrane-bounded organelle" EXACT [] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure disjoint_from: GO:0043230 ! extracellular organelle relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure [Term] id: GO:0043230 name: extracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region relationship: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure [Term] id: GO:0043232 name: intracellular membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "intracellular non-membrane-bounded organelle" EXACT [] synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! membraneless organelle is_a: GO:0043229 ! intracellular organelle intersection_of: GO:0043228 ! membraneless organelle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] subset: goslim_mouse is_a: GO:0031974 ! membrane-enclosed lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0043226 ! part of organelle relationship: BFO:0000050 GO:0043226 ! part of organelle [Term] id: GO:0043235 name: receptor complex namespace: cellular_component def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity relationship: RO:0002215 GO:0038023 ! capable of signaling receptor activity [Term] id: GO:0043242 name: negative regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "down regulation of protein complex disassembly" EXACT [] synonym: "down-regulation of protein complex disassembly" EXACT [] synonym: "downregulation of protein complex disassembly" EXACT [] synonym: "inhibition of protein complex disassembly" NARROW [] synonym: "negative regulation of protein complex disassembly" RELATED [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly relationship: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly [Term] id: GO:0043243 name: positive regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "activation of protein complex disassembly" NARROW [] synonym: "positive regulation of protein complex disassembly" RELATED [] synonym: "stimulation of protein complex disassembly" NARROW [] synonym: "up regulation of protein complex disassembly" EXACT [] synonym: "up-regulation of protein complex disassembly" EXACT [] synonym: "upregulation of protein complex disassembly" EXACT [] is_a: GO:0043244 ! regulation of protein-containing complex disassembly is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly relationship: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly [Term] id: GO:0043244 name: regulation of protein-containing complex disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] synonym: "regulation of protein complex disassembly" RELATED [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly relationship: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly [Term] id: GO:0043249 name: erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] synonym: "RBC maturation" EXACT [CL:0000232] synonym: "red blood cell maturation" EXACT [CL:0000232] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000232 ! results in maturation of erythrocyte relationship: BFO:0000050 GO:0048821 ! part of erythrocyte development relationship: RO:0002299 CL:0000232 ! results in maturation of erythrocyte [Term] id: GO:0043253 name: chloroplast ribosome namespace: cellular_component def: "A ribosome contained within a chloroplast." [GOC:ecd] is_a: GO:0009547 ! plastid ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma [Term] id: GO:0043254 name: regulation of protein-containing complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] synonym: "regulation of protein complex assembly" RELATED [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly relationship: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly [Term] id: GO:0043255 name: regulation of carbohydrate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] synonym: "regulation of carbohydrate anabolism" EXACT [] synonym: "regulation of carbohydrate biosynthesis" EXACT [] synonym: "regulation of carbohydrate formation" EXACT [] synonym: "regulation of carbohydrate synthesis" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process relationship: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process [Term] id: GO:0043264 name: extracellular membraneless organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] synonym: "extracellular non-membrane-bounded organelle" EXACT [] synonym: "extracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! membraneless organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043228 ! membraneless organelle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0043269 name: regulation of monoatomic ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "regulation of ion transport" BROAD [] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006811 ! regulates monoatomic ion transport relationship: RO:0002211 GO:0006811 ! regulates monoatomic ion transport [Term] id: GO:0043270 name: positive regulation of monoatomic ion transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "activation of ion transport" NARROW [] synonym: "stimulation of ion transport" NARROW [] synonym: "up regulation of ion transport" EXACT [] synonym: "up-regulation of ion transport" EXACT [] synonym: "upregulation of ion transport" EXACT [] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport relationship: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport [Term] id: GO:0043271 name: negative regulation of monoatomic ion transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] synonym: "down regulation of ion transport" EXACT [] synonym: "down-regulation of ion transport" EXACT [] synonym: "downregulation of ion transport" EXACT [] synonym: "inhibition of ion transport" NARROW [] synonym: "negative regulation of ion transport" BROAD [] is_a: GO:0043269 ! regulation of monoatomic ion transport is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport relationship: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport [Term] id: GO:0043292 name: contractile muscle fiber namespace: cellular_component def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] synonym: "contractile fibre" EXACT [] is_a: GO:0043232 ! intracellular membraneless organelle is_a: GO:0099512 ! supramolecular fiber relationship: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0043296 name: apical junction complex namespace: cellular_component def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] synonym: "apical cell junction complex" EXACT [GOC:mah] synonym: "apical junction" EXACT [] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0043297 name: apical junction assembly namespace: biological_process def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] synonym: "apical junction complex assembly" EXACT [GOC:mah] is_a: GO:0007043 ! cell-cell junction assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043296 ! results in assembly of apical junction complex relationship: RO:0002588 GO:0043296 ! results in assembly of apical junction complex [Term] id: GO:0043362 name: nucleate erythrocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] synonym: "nucleate RBC maturation" EXACT [CL:0000232] synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] is_a: GO:0043249 ! erythrocyte maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte relationship: BFO:0000050 GO:0048823 ! part of nucleate erythrocyte development relationship: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte [Term] id: GO:0043363 name: nucleate erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] synonym: "nucleate RBC differentiation" EXACT [CL:0000232] synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0030218 ! erythrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte relationship: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte [Term] id: GO:0043385 name: mycotoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin metabolism" EXACT [] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0043386 name: mycotoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] synonym: "mycotoxin anabolism" EXACT [] synonym: "mycotoxin biosynthesis" EXACT [] synonym: "mycotoxin formation" EXACT [] synonym: "mycotoxin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0043385 ! mycotoxin metabolic process [Term] id: GO:0043388 name: positive regulation of DNA binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: gocheck_do_not_annotate synonym: "activation of DNA binding" NARROW [] synonym: "stimulation of DNA binding" NARROW [] synonym: "up regulation of DNA binding" EXACT [] synonym: "up-regulation of DNA binding" EXACT [] synonym: "upregulation of DNA binding" EXACT [] is_a: GO:0051099 ! positive regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003677 ! positively regulates DNA binding relationship: RO:0002213 GO:0003677 ! positively regulates DNA binding [Term] id: GO:0043392 name: negative regulation of DNA binding namespace: biological_process def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: gocheck_do_not_annotate synonym: "down regulation of DNA binding" EXACT [] synonym: "down-regulation of DNA binding" EXACT [] synonym: "downregulation of DNA binding" EXACT [] synonym: "inhibition of DNA binding" NARROW [] is_a: GO:0051100 ! negative regulation of binding is_a: GO:0051101 ! regulation of DNA binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003677 ! negatively regulates DNA binding relationship: RO:0002212 GO:0003677 ! negatively regulates DNA binding [Term] id: GO:0043393 name: regulation of protein binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] subset: gocheck_do_not_annotate is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005515 ! regulates protein binding relationship: RO:0002211 GO:0005515 ! regulates protein binding [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: gocheck_obsoletion_candidate subset: goslim_pir is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0043434 name: response to peptide hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25905 ! has primary input relationship: RO:0004009 CHEBI:25905 ! has primary input [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35406 ! has primary input or output oxoanion relationship: RO:0004007 CHEBI:35406 ! has primary input or output oxoanion [Term] id: GO:0043455 name: regulation of secondary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] synonym: "regulation of secondary metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019748 ! regulates secondary metabolic process relationship: RO:0002211 GO:0019748 ! regulates secondary metabolic process [Term] id: GO:0043462 name: regulation of ATP-dependent activity namespace: biological_process def: "Any process that modulates the rate of an ATP-dependent activity." [GOC:jl] subset: gocheck_obsoletion_candidate synonym: "regulation of adenosinetriphosphatase activity" EXACT [] synonym: "regulation of ATPase activity" EXACT [] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140657 ! regulates ATP-dependent activity relationship: RO:0002211 GO:0140657 ! regulates ATP-dependent activity [Term] id: GO:0043470 name: regulation of carbohydrate catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process relationship: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0008150 ! biological_process relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0043476 name: pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] synonym: "pigment accumulation in response to external stimulus" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0043473 ! pigmentation [Term] id: GO:0043482 name: cellular pigment accumulation namespace: biological_process def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl] is_a: GO:0033059 ! cellular pigmentation is_a: GO:0043476 ! pigment accumulation is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0043500 name: muscle adaptation namespace: biological_process def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] subset: goslim_pir synonym: "muscle plasticity" RELATED [] is_a: GO:0003012 ! muscle system process is_a: GO:0050896 ! response to stimulus relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue [Term] id: GO:0043501 name: skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] synonym: "skeletal muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation intersection_of: GO:0043500 ! muscle adaptation intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue [Term] id: GO:0043502 name: regulation of muscle adaptation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] synonym: "regulation of muscle plasticity" RELATED [] is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043500 ! regulates muscle adaptation relationship: RO:0002211 GO:0043500 ! regulates muscle adaptation [Term] id: GO:0043523 name: regulation of neuron apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of neuronal cells" EXACT [] synonym: "regulation of apoptosis of neurons" EXACT [] synonym: "regulation of neuron apoptosis" NARROW [] synonym: "regulation of neuron programmed cell death" EXACT [] synonym: "regulation of neuronal cell programmed cell death" EXACT [] synonym: "regulation of programmed cell death of neuronal cells" EXACT [] synonym: "regulation of programmed cell death, neurons" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051402 ! regulates neuron apoptotic process relationship: RO:0002211 GO:0051402 ! regulates neuron apoptotic process [Term] id: GO:0043524 name: negative regulation of neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "down regulation of neuron apoptosis" EXACT [] synonym: "down-regulation of neuron apoptosis" EXACT [] synonym: "downregulation of neuron apoptosis" EXACT [] synonym: "inhibition of neuron apoptosis" NARROW [] synonym: "negative regulation of neuron apoptosis" NARROW [] synonym: "negative regulation of programmed cell death, neurons" EXACT [] synonym: "neuron survival" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process relationship: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process [Term] id: GO:0043525 name: positive regulation of neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "activation of neuron apoptosis" NARROW [] synonym: "positive regulation of neuron apoptosis" NARROW [] synonym: "positive regulation of programmed cell death, neurons" EXACT [] synonym: "stimulation of neuron apoptosis" NARROW [] synonym: "up regulation of neuron apoptosis" EXACT [] synonym: "up-regulation of neuron apoptosis" EXACT [] synonym: "upregulation of neuron apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process relationship: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process [Term] id: GO:0043534 name: blood vessel endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264] is_a: GO:0043542 ! endothelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000071 ! results in movement of blood vessel endothelial cell relationship: RO:0002565 CL:0000071 ! results in movement of blood vessel endothelial cell [Term] id: GO:0043535 name: regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] is_a: GO:0010594 ! regulation of endothelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043534 ! regulates blood vessel endothelial cell migration relationship: RO:0002211 GO:0043534 ! regulates blood vessel endothelial cell migration [Term] id: GO:0043536 name: positive regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "activation of blood vessel endothelial cell migration" NARROW [] synonym: "stimulation of blood vessel endothelial cell migration" NARROW [] synonym: "up regulation of blood vessel endothelial cell migration" EXACT [] synonym: "up-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "upregulation of blood vessel endothelial cell migration" EXACT [] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043534 ! positively regulates blood vessel endothelial cell migration relationship: RO:0002213 GO:0043534 ! positively regulates blood vessel endothelial cell migration [Term] id: GO:0043537 name: negative regulation of blood vessel endothelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] synonym: "down regulation of blood vessel endothelial cell migration" EXACT [] synonym: "down-regulation of blood vessel endothelial cell migration" EXACT [] synonym: "downregulation of blood vessel endothelial cell migration" EXACT [] synonym: "inhibition of blood vessel endothelial cell migration" NARROW [] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043534 ! negatively regulates blood vessel endothelial cell migration relationship: RO:0002212 GO:0043534 ! negatively regulates blood vessel endothelial cell migration [Term] id: GO:0043542 name: endothelial cell migration namespace: biological_process def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell relationship: RO:0002565 CL:0000115 ! results in movement of endothelial cell [Term] id: GO:0043555 name: regulation of translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] synonym: "translational stress response" EXACT [] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000050 GO:0033554 ! part of cellular response to stress [Term] id: GO:0043556 name: regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0032055 ! negative regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation relationship: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress [Term] id: GO:0043558 name: regulation of translational initiation in response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl] synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0043555 ! regulation of translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0043572 name: plastid fission namespace: biological_process def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0009536 ! results in fission of plastid relationship: GOREL:0002004 GO:0009536 ! results in fission of plastid [Term] id: GO:0043576 name: regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system relationship: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system [Term] id: GO:0043586 name: tongue development namespace: biological_process def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa development" NARROW [] synonym: "lingua development" NARROW [] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001723 ! results in development of tongue relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002296 UBERON:0001723 ! results in development of tongue [Term] id: GO:0043587 name: tongue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] synonym: "glossa morphogenesis" NARROW [] synonym: "lingua morphogenesis" EXACT [] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001723 ! results in morphogenesis of tongue relationship: BFO:0000050 GO:0043586 ! part of tongue development relationship: RO:0002298 UBERON:0001723 ! results in morphogenesis of tongue [Term] id: GO:0043588 name: skin development namespace: biological_process def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] synonym: "animal skin development" EXACT [] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002097 ! results in development of skin of body relationship: RO:0002296 UBERON:0002097 ! results in development of skin of body [Term] id: GO:0043589 name: skin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body relationship: BFO:0000050 GO:0043588 ! part of skin development relationship: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body [Term] id: GO:0043603 name: amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "amide metabolism" EXACT [] synonym: "cellular amide metabolic process" EXACT [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:32988 ! has primary input or output amide relationship: RO:0004007 CHEBI:32988 ! has primary input or output amide [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:32988 ! has primary output amide relationship: RO:0004008 CHEBI:32988 ! has primary output amide [Term] id: GO:0043605 name: amide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] synonym: "cellular amide catabolic process" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0043603 ! amide metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004008 CHEBI:32988 ! has primary output amide relationship: RO:0004008 CHEBI:32988 ! has primary output amide [Term] id: GO:0043615 name: astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators] synonym: "astrocyte migration" EXACT [] synonym: "astrocytic glial cell migration" EXACT [] is_a: GO:0008347 ! glial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000127 ! results in movement of astrocyte relationship: RO:0002565 CL:0000127 ! results in movement of astrocyte [Term] id: GO:0043648 name: dicarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "dicarboxylate metabolic process" EXACT [] synonym: "dicarboxylate metabolism" EXACT [] synonym: "dicarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:35693 ! has primary input or output dicarboxylic acid anion relationship: RO:0004007 CHEBI:35693 ! has primary input or output dicarboxylic acid anion [Term] id: GO:0043649 name: dicarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate catabolic process" EXACT [] synonym: "dicarboxylate catabolism" EXACT [] synonym: "dicarboxylic acid breakdown" EXACT [] synonym: "dicarboxylic acid catabolism" EXACT [] synonym: "dicarboxylic acid degradation" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion relationship: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion [Term] id: GO:0043650 name: dicarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "dicarboxylate biosynthesis" EXACT [] synonym: "dicarboxylate biosynthetic process" EXACT [] synonym: "dicarboxylic acid anabolism" EXACT [] synonym: "dicarboxylic acid biosynthesis" EXACT [] synonym: "dicarboxylic acid formation" EXACT [] synonym: "dicarboxylic acid synthesis" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35693 ! has primary output dicarboxylic acid anion relationship: RO:0004008 CHEBI:35693 ! has primary output dicarboxylic acid anion [Term] id: GO:0043903 name: regulation of biological process involved in symbiotic interaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] comment: regulation of interspecies interactions between organisms synonym: "regulation of interspecies interactions between organisms" BROAD [] synonym: "regulation of symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "regulation of symbiotic process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044403 ! regulates biological process involved in symbiotic interaction relationship: RO:0002211 GO:0044403 ! regulates biological process involved in symbiotic interaction [Term] id: GO:0043931 name: ossification involved in bone maturation namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo] synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034] synonym: "ossification involved in skeletal development" EXACT [GOC:dph] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: BFO:0000050 GO:0070977 ! part of bone maturation relationship: BFO:0000050 GO:0070977 ! part of bone maturation [Term] id: GO:0043932 name: ossification involved in bone remodeling namespace: biological_process def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo] synonym: "ossification involved in bone remodelling" EXACT [] is_a: GO:0001503 ! ossification intersection_of: GO:0001503 ! ossification intersection_of: BFO:0000050 GO:0046849 ! part of bone remodeling relationship: BFO:0000050 GO:0046849 ! part of bone remodeling [Term] id: GO:0043933 name: protein-containing complex organization namespace: biological_process alt_id: GO:0034600 alt_id: GO:0034621 alt_id: GO:0071822 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "cellular macromolecular complex organization" RELATED [] synonym: "cellular macromolecular complex subunit organisation" RELATED [] synonym: "cellular macromolecular complex subunit organization" RELATED [] synonym: "macromolecular complex organization" RELATED [] synonym: "macromolecular complex subunit organisation" RELATED [] synonym: "macromolecular complex subunit organization" RELATED [] synonym: "protein complex subunit organisation" EXACT [GOC:mah] synonym: "protein complex subunit organization" EXACT [] synonym: "protein-containing complex subunit organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032991 ! results in organization of protein-containing complex relationship: RO:0002592 GO:0032991 ! results in organization of protein-containing complex created_by: mah creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators] subset: goslim_metagenomics subset: goslim_yeast xref: Wikipedia:Spore is_a: GO:0032502 ! developmental process [Term] id: GO:0043935 name: sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0034293 ! sexual sporulation intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0043936 name: asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators] synonym: "asexual reproduction resulting in the formation of a cellular spore" EXACT [GOC:di] synonym: "asexual sporulation resulting in the formation of a viable spore" BROAD [GOC:di] is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0030436 ! asexual sporulation [Term] id: GO:0043937 name: regulation of sporulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043934 ! regulates sporulation relationship: RO:0002211 GO:0043934 ! regulates sporulation [Term] id: GO:0043938 name: positive regulation of sporulation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0043934 ! positively regulates sporulation relationship: RO:0002213 GO:0043934 ! positively regulates sporulation [Term] id: GO:0043939 name: negative regulation of sporulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] is_a: GO:0043937 ! regulation of sporulation is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0043934 ! negatively regulates sporulation relationship: RO:0002212 GO:0043934 ! negatively regulates sporulation [Term] id: GO:0043940 name: regulation of sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] is_a: GO:0034306 ! regulation of sexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043935 ! regulates sexual sporulation resulting in formation of a cellular spore relationship: RO:0002211 GO:0043935 ! regulates sexual sporulation resulting in formation of a cellular spore [Term] id: GO:0043943 name: regulation of asexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] is_a: GO:0034305 ! regulation of asexual sporulation is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043936 ! regulates asexual sporulation resulting in formation of a cellular spore relationship: RO:0002211 GO:0043936 ! regulates asexual sporulation resulting in formation of a cellular spore [Term] id: GO:0044001 name: migration in host namespace: biological_process def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] synonym: "migration within host" EXACT [] is_a: GO:0051701 ! biological process involved in interaction with host [Term] id: GO:0044057 name: regulation of system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003008 ! regulates system process relationship: RO:0002211 GO:0003008 ! regulates system process [Term] id: GO:0044058 name: regulation of digestive system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022600 ! regulates digestive system process relationship: RO:0002211 GO:0022600 ! regulates digestive system process [Term] id: GO:0044060 name: regulation of endocrine process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] synonym: "regulation of endocrine system process" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050886 ! regulates endocrine process relationship: RO:0002211 GO:0050886 ! regulates endocrine process [Term] id: GO:0044065 name: regulation of respiratory system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003016 ! regulates respiratory system process relationship: RO:0002211 GO:0003016 ! regulates respiratory system process [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0044087 name: regulation of cellular component biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] subset: gocheck_do_not_annotate is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044085 ! regulates cellular component biogenesis relationship: RO:0002211 GO:0044085 ! regulates cellular component biogenesis [Term] id: GO:0044088 name: regulation of vacuole organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007033 ! regulates vacuole organization relationship: RO:0002211 GO:0007033 ! regulates vacuole organization [Term] id: GO:0044089 name: positive regulation of cellular component biogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis relationship: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis [Term] id: GO:0044090 name: positive regulation of vacuole organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007033 ! positively regulates vacuole organization relationship: RO:0002213 GO:0007033 ! positively regulates vacuole organization [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0016020 ! has primary output membrane relationship: RO:0004008 GO:0016020 ! has primary output membrane [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: gocheck_do_not_annotate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003674 ! negatively regulates molecular_function relationship: RO:0002212 GO:0003674 ! negatively regulates molecular_function creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] subset: gocheck_obsoletion_candidate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003674 ! positively regulates molecular_function relationship: RO:0002213 GO:0003674 ! positively regulates molecular_function creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044111 name: formation of structure involved in a symbiotic process namespace: biological_process alt_id: GO:0044115 alt_id: GO:0044152 def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] synonym: "development during symbiotic interaction" RELATED [GOC:dph] synonym: "development involved in symbiotic interaction" RELATED [] synonym: "development of symbiont during interaction with host" RELATED [GOC:dph] synonym: "development of symbiont involved in interaction with host" RELATED [] synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph] synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW [] is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms created_by: jl creation_date: 2009-07-30T02:26:46Z [Term] id: GO:0044114 name: development of symbiont in host namespace: biological_process alt_id: GO:0044122 alt_id: GO:0044124 def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'biological process involved in interaction with host ; GO:0051701. synonym: "development of symbiont in host intercellular space" NARROW [] synonym: "development of symbiont in host vascular tissue" NARROW [] is_a: GO:0044111 ! formation of structure involved in a symbiotic process created_by: jl creation_date: 2009-07-30T03:39:25Z [Term] id: GO:0044127 name: regulation of development of symbiont in host namespace: biological_process def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'. is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044114 ! regulates development of symbiont in host relationship: RO:0002211 GO:0044114 ! regulates development of symbiont in host created_by: jl creation_date: 2009-08-04T02:11:08Z [Term] id: GO:0044145 name: modulation of formation of structure involved in a symbiotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'. synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph] synonym: "modulation of development of symbiont involved in interaction with host" RELATED [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044111 ! regulates formation of structure involved in a symbiotic process relationship: RO:0002211 GO:0044111 ! regulates formation of structure involved in a symbiotic process created_by: jl creation_date: 2009-08-06T01:57:38Z [Term] id: GO:0044207 name: translation initiation ternary complex namespace: cellular_component def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] synonym: "translation initiation (ternary) complex" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex relationship: BFO:0000050 GO:0005737 ! part of cytoplasm created_by: jl creation_date: 2009-10-22T02:38:55Z [Term] id: GO:0044217 name: other organism part namespace: cellular_component def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0110165 ! cellular anatomical structure created_by: jl creation_date: 2009-11-12T01:18:21Z [Term] id: GO:0044237 name: obsolete cellular metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] comment: The reason for obsoletion is that this term is now redundant with GO:0008152, metabolic process synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] xref: Reactome:R-HSA-1428517 "Aerobic respiration and respiratory electron transport" [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_euk_cellular_processes_ribbon subset: goslim_pir subset: goslim_plant_ribbon subset: goslim_prokaryote_ribbon synonym: "primary metabolism" EXACT [] xref: Wikipedia:Primary_metabolite is_a: GO:0008152 ! metabolic process [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: jl creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule catabolism" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044281 ! small molecule metabolic process creation_date: 2010-01-26T12:06:10Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process created_by: jl creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044292 name: dendrite terminus namespace: cellular_component def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134] synonym: "dendrite terminal" EXACT [] synonym: "dendrite terminal specialization" RELATED [] synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134] synonym: "terminal specialization of a dendrite" EXACT [] xref: NIF_Subcellular:sao28175134 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0030425 ! part of dendrite creation_date: 2010-02-04T03:14:37Z [Term] id: GO:0044293 name: dendriole namespace: cellular_component def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904] xref: NIF_Subcellular:sao28175134 xref: NIF_Subcellular:sao295057932 is_a: GO:0044292 ! dendrite terminus creation_date: 2010-02-04T03:32:02Z [Term] id: GO:0044297 name: cell body namespace: cellular_component def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. synonym: "cell soma" EXACT [] xref: FBbt:00005107 xref: FMA:67301 xref: Wikipedia:Cell_body is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell creation_date: 2010-02-05T10:37:16Z [Term] id: GO:0044346 name: fibroblast apoptotic process namespace: biological_process def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf] synonym: "fibroblast apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000057 ! occurs in fibroblast relationship: BFO:0000066 CL:0000057 ! occurs in fibroblast creation_date: 2010-09-23T11:33:38Z [Term] id: GO:0044380 name: protein localization to cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005856 ! has target end location cytoskeleton relationship: RO:0002339 GO:0005856 ! has target end location cytoskeleton creation_date: 2011-12-13T11:43:24Z [Term] id: GO:0044403 name: biological process involved in symbiotic interaction namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 alt_id: GO:0072519 alt_id: GO:0085031 def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, PMID:31257129] subset: goslim_chembl synonym: "commensalism" NARROW [] synonym: "host-pathogen interaction" NARROW [] synonym: "parasitism" NARROW [] synonym: "symbiosis" RELATED [] synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "symbiotic interaction" RELATED [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" RELATED [] synonym: "symbiotic interaction between species" RELATED [] synonym: "symbiotic process" RELATED [] is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms is_a: GO:0051704 ! multi-organism process [Term] id: GO:0044409 name: entry into host namespace: biological_process alt_id: GO:0030260 alt_id: GO:0044411 alt_id: GO:0051806 alt_id: GO:0051828 alt_id: GO:0051830 alt_id: GO:0075052 alt_id: GO:0085027 alt_id: GO:0085028 def: "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:vw] subset: goslim_virus synonym: "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb] synonym: "entry into cell of other organism involved in symbiotic interaction" RELATED [] synonym: "entry into host" EXACT [] synonym: "entry into host cell via penetration peg" NARROW [] synonym: "entry into host through host barriers" RELATED [] synonym: "entry into host via a specialized structure during symbiotic interaction" NARROW [] synonym: "entry into host via enzymatic degradation of host anatomical structure" NARROW [] synonym: "entry into host via enzymatic degradation of host cuticle" NARROW [] synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "entry into other organism involved in symbiotic interaction" RELATED [] synonym: "host invasion" EXACT [] synonym: "host penetration" EXACT [GOC:vw] synonym: "invasion into host" EXACT [] synonym: "invasion into other organism" RELATED [] synonym: "invasion of host" EXACT [] synonym: "invasion of other organism" RELATED [] synonym: "invasive growth" RELATED [] synonym: "other organism invasion" RELATED [] synonym: "penetration into host" EXACT [GOC:vw] synonym: "penetration into host via a specialized structure" NARROW [GOC:vw] synonym: "penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw] xref: Reactome:R-HSA-173107 "Binding and entry of HIV virion" is_a: GO:0051701 ! biological process involved in interaction with host [Term] id: GO:0044419 name: biological process involved in interspecies interaction between organisms namespace: biological_process def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "interaction with another species" EXACT [] synonym: "interspecies interaction" EXACT [] synonym: "interspecies interaction between organisms" EXACT [] synonym: "interspecies interaction with other organisms" EXACT [] xref: Reactome:R-HSA-9824443 "Parasitic Infection Pathways" is_a: GO:0008150 ! biological_process [Term] id: GO:0044423 name: virion component namespace: cellular_component def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" RELATED [] synonym: "virion" RELATED [] synonym: "virion part" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component disjoint_from: GO:0110165 ! cellular anatomical structure [Term] id: GO:0044458 name: motile cilium assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf] synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "motile primary cilium assembly" RELATED [] synonym: "motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:0060271 ! cilium assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031514 ! results in assembly of motile cilium relationship: RO:0002588 GO:0031514 ! results in assembly of motile cilium creation_date: 2015-02-06T17:23:23Z [Term] id: GO:0044464 name: obsolete cell part namespace: cellular_component def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602] synonym: "protoplast" RELATED [GOC:mah] [Term] id: GO:0044550 name: secondary metabolite biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] subset: goslim_prokaryote synonym: "secondary metabolite biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019748 ! secondary metabolic process created_by: jl creation_date: 2012-03-29T01:55:18Z [Term] id: GO:0044565 name: dendritic cell proliferation namespace: biological_process def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816] is_a: GO:0032943 ! mononuclear cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000451 ! acts on population of dendritic cell relationship: RO:0012003 CL:0000451 ! acts on population of dendritic cell creation_date: 2012-04-05T04:31:39Z [Term] id: GO:0044566 name: chondrocyte activation namespace: biological_process def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl] is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000138 ! has primary input chondrocyte relationship: RO:0004009 CL:0000138 ! has primary input chondrocyte creation_date: 2012-04-05T04:45:38Z [Term] id: GO:0044703 name: multi-organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] subset: gocheck_do_not_annotate subset: goslim_drosophila is_a: GO:0022414 ! reproductive process creation_date: 2012-09-19T15:56:30Z [Term] id: GO:0044706 name: multi-multicellular organism process namespace: biological_process def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl] is_a: GO:0032501 ! multicellular organismal process creation_date: 2012-09-19T16:06:16Z [Term] id: GO:0044743 name: protein transmembrane import into intracellular organelle namespace: biological_process def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl] is_a: GO:0065002 ! intracellular protein transmembrane transport is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0043229 ! has target end location intracellular organelle intersection_of: RO:0002342 GO:0031090 ! results in transport across organelle membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0043229 ! has target end location intracellular organelle relationship: RO:0002342 GO:0031090 ! results in transport across organelle membrane creation_date: 2012-11-07T15:37:36Z [Term] id: GO:0044782 name: cilium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. subset: goslim_drosophila subset: goslim_generic synonym: "microtubule-based flagellum organization" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005929 ! results in organization of cilium relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002592 GO:0005929 ! results in organization of cilium creation_date: 2013-03-27T15:09:58Z [Term] id: GO:0044848 name: biological phase namespace: biological_process def: "A distinct period or stage in a biological process or cycle." [GOC:jl] comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. subset: gocheck_do_not_annotate is_a: GO:0008150 ! biological_process disjoint_from: GO:0050896 ! response to stimulus disjoint_from: GO:0051179 ! localization disjoint_from: GO:0071840 ! cellular component organization or biogenesis created_by: jl creation_date: 2014-07-16T13:12:40Z [Term] id: GO:0044877 name: protein-containing complex binding namespace: molecular_function alt_id: GO:0032403 def: "Binding to a macromolecular complex." [GOC:jl] subset: goslim_chembl synonym: "macromolecular complex binding" RELATED [] synonym: "protein complex binding" EXACT [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex created_by: jl creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0061025 ! membrane fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005886 ! results in fusion of plasma membrane relationship: RO:0012008 GO:0005886 ! results in fusion of plasma membrane [Term] id: GO:0045037 name: protein import into chloroplast stroma namespace: biological_process def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363] synonym: "chloroplast stroma protein import" EXACT [] synonym: "protein transport into chloroplast stroma" EXACT [] is_a: GO:0071806 ! protein transmembrane transport is_a: GO:0072596 ! establishment of protein localization to chloroplast intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002339 GO:0009570 ! has target end location chloroplast stroma intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002339 GO:0009570 ! has target end location chloroplast stroma [Term] id: GO:0045087 name: innate immune response namespace: biological_process alt_id: GO:0002226 def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] synonym: "innate immunity" EXACT [GOC:pg] synonym: "nonspecific immune response" EXACT [] xref: Reactome:R-HSA-168249 "Innate Immune System" xref: Wikipedia:Innate_immune_system is_a: GO:0006955 ! immune response is_a: GO:0140546 ! defense response to symbiont [Term] id: GO:0045088 name: regulation of innate immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045087 ! regulates innate immune response relationship: RO:0002211 GO:0045087 ! regulates innate immune response [Term] id: GO:0045089 name: positive regulation of innate immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] synonym: "stimulation of innate immune response" NARROW [] synonym: "up regulation of innate immune response" EXACT [] synonym: "up-regulation of innate immune response" EXACT [] synonym: "upregulation of innate immune response" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045087 ! positively regulates innate immune response relationship: RO:0002213 GO:0045087 ! positively regulates innate immune response [Term] id: GO:0045124 name: regulation of bone resorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai] is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045453 ! regulates bone resorption relationship: RO:0002211 GO:0045453 ! regulates bone resorption [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: BFO:0000050 GO:0140013 ! part of meiotic nuclear division relationship: BFO:0000050 GO:0140013 ! part of meiotic nuclear division [Term] id: GO:0045137 name: development of primary sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0003006 ! developmental process involved in reproduction relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: BFO:0000050 GO:0007548 ! part of sex differentiation [Term] id: GO:0045144 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle intersection_of: GO:0000819 ! sister chromatid segregation intersection_of: BFO:0000050 GO:0007135 ! part of meiosis II relationship: BFO:0000050 GO:0007135 ! part of meiosis II [Term] id: GO:0045165 name: cell fate commitment namespace: biological_process def: "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185] comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. is_a: GO:0048869 ! cellular developmental process relationship: BFO:0000050 GO:0030154 ! part of cell differentiation [Term] id: GO:0045168 name: cell-cell signaling involved in cell fate commitment namespace: biological_process def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell fate commitment, cell-cell signaling" EXACT [] synonym: "cell fate commitment, cell-cell signalling" EXACT [] synonym: "cell-cell signaling during in cell fate commitment" EXACT [] synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] synonym: "cell-cell signalling during cell fate commitment" EXACT [] synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb] synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0045165 ! part of cell fate commitment relationship: BFO:0000050 GO:0045165 ! part of cell fate commitment [Term] id: GO:0045177 name: apical part of cell namespace: cellular_component def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "apical region of cell" EXACT [GOC:krc] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0045179 name: apical cortex namespace: cellular_component def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: BFO:0000050 GO:0045177 ! part of apical part of cell relationship: BFO:0000050 GO:0045177 ! part of apical part of cell [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! intracellular protein localization is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: RO:0004009 CHEBI:36080 ! has primary input protein [Term] id: GO:0045185 name: maintenance of protein location namespace: biological_process def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] synonym: "active protein retrieval" NARROW [] synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] synonym: "protein retention" NARROW [] synonym: "protein sequestering" NARROW [] is_a: GO:0051235 ! maintenance of location relationship: BFO:0000050 GO:0008104 ! part of intracellular protein localization [Term] id: GO:0045196 name: establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: BFO:0000050 GO:0055059 ! part of asymmetric neuroblast division [Term] id: GO:0045200 name: establishment of neuroblast polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] synonym: "establishment of neuroblast cell polarity" EXACT [] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata) relationship: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata) [Term] id: GO:0045202 name: synapse namespace: cellular_component def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] subset: goslim_agr subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_synapse synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497] synonym: "synaptic junction" EXACT [] xref: NIF_Subcellular:sao914572699 xref: Wikipedia:Chemical_synapse is_a: GO:0030054 ! cell junction relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0045211 name: postsynaptic membrane namespace: cellular_component def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] subset: goslim_synapse synonym: "post-synaptic membrane" EXACT [] is_a: GO:0097060 ! synaptic membrane relationship: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0045214 name: sarcomere organization namespace: biological_process def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] synonym: "sarcomere alignment" EXACT [] synonym: "sarcomere organisation" EXACT [] is_a: GO:0031032 ! actomyosin structure organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030017 ! results in organization of sarcomere relationship: BFO:0000050 GO:0030239 ! part of myofibril assembly relationship: RO:0002592 GO:0030017 ! results in organization of sarcomere [Term] id: GO:0045216 name: cell-cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "cell-cell junction assembly and maintenance" EXACT [] synonym: "cell-cell junction biogenesis" RELATED [] synonym: "cell-cell junction organisation" EXACT [GOC:mah] synonym: "intercellular junction assembly and maintenance" EXACT [] xref: Reactome:R-HSA-421270 "Cell-cell junction organization" is_a: GO:0034330 ! cell junction organization intersection_of: GO:0034330 ! cell junction organization intersection_of: RO:0002592 GO:0005911 ! results in organization of cell-cell junction relationship: RO:0002592 GO:0005911 ! results in organization of cell-cell junction [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "external encapsulating structure organisation" EXACT [] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure relationship: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure [Term] id: GO:0045296 name: cadherin binding namespace: molecular_function def: "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] is_a: GO:0050839 ! cell adhesion molecule binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001327 ! has primary input cadherin relationship: RO:0004009 PR:000001327 ! has primary input cadherin [Term] id: GO:0045321 name: leukocyte activation namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] synonym: "immune cell activation" EXACT [] synonym: "leucocyte activation" EXACT [] xref: Wikipedia:Immunologic_activation is_a: GO:0001775 ! cell activation is_a: GO:0002376 ! immune system process intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000738 ! has primary input leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0004009 CL:0000738 ! has primary input leukocyte [Term] id: GO:0045444 name: fat cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] synonym: "adipocyte cell differentiation" EXACT [] synonym: "adipocyte differentiation" EXACT [] synonym: "adipogenesis" RELATED [] synonym: "adipose cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte relationship: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte [Term] id: GO:0045445 name: myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "myoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast relationship: BFO:0000050 GO:0061061 ! part of muscle structure development relationship: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast [Term] id: GO:0045446 name: endothelial cell differentiation namespace: biological_process def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell relationship: BFO:0000050 GO:0003158 ! part of endothelium development relationship: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell [Term] id: GO:0045453 name: bone resorption namespace: biological_process def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780] xref: Wikipedia:Bone_resorption is_a: GO:0001894 ! tissue homeostasis relationship: BFO:0000050 GO:0046849 ! part of bone remodeling [Term] id: GO:0045580 name: regulation of T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development" RELATED [GOC:add] synonym: "regulation of T lymphocyte differentiation" EXACT [] synonym: "regulation of T-cell differentiation" EXACT [] synonym: "regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0050863 ! regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030217 ! regulates T cell differentiation relationship: RO:0002211 GO:0030217 ! regulates T cell differentiation [Term] id: GO:0045581 name: negative regulation of T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of T cell differentiation" EXACT [] synonym: "down-regulation of T cell differentiation" EXACT [] synonym: "downregulation of T cell differentiation" EXACT [] synonym: "inhibition of T cell differentiation" NARROW [] synonym: "negative regulation of T cell development" RELATED [GOC:add] synonym: "negative regulation of T lymphocyte differentiation" EXACT [] synonym: "negative regulation of T-cell differentiation" EXACT [] synonym: "negative regulation of T-lymphocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation is_a: GO:0050868 ! negative regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030217 ! negatively regulates T cell differentiation relationship: RO:0002212 GO:0030217 ! negatively regulates T cell differentiation [Term] id: GO:0045582 name: positive regulation of T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of T cell differentiation" NARROW [] synonym: "positive regulation of T cell development" RELATED [GOC:add] synonym: "positive regulation of T lymphocyte differentiation" EXACT [] synonym: "positive regulation of T-cell differentiation" EXACT [] synonym: "positive regulation of T-lymphocyte differentiation" EXACT [] synonym: "stimulation of T cell differentiation" NARROW [] synonym: "up regulation of T cell differentiation" EXACT [] synonym: "up-regulation of T cell differentiation" EXACT [] synonym: "upregulation of T cell differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation is_a: GO:0050870 ! positive regulation of T cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030217 ! positively regulates T cell differentiation relationship: RO:0002213 GO:0030217 ! positively regulates T cell differentiation [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030154 ! regulates cell differentiation relationship: RO:0002211 GO:0030154 ! regulates cell differentiation [Term] id: GO:0045596 name: negative regulation of cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "down regulation of cell differentiation" EXACT [] synonym: "down-regulation of cell differentiation" EXACT [] synonym: "downregulation of cell differentiation" EXACT [] synonym: "inhibition of cell differentiation" NARROW [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030154 ! negatively regulates cell differentiation relationship: RO:0002212 GO:0030154 ! negatively regulates cell differentiation [Term] id: GO:0045597 name: positive regulation of cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] synonym: "activation of cell differentiation" NARROW [] synonym: "stimulation of cell differentiation" NARROW [] synonym: "up regulation of cell differentiation" EXACT [] synonym: "up-regulation of cell differentiation" EXACT [] synonym: "upregulation of cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030154 ! positively regulates cell differentiation relationship: RO:0002213 GO:0030154 ! positively regulates cell differentiation [Term] id: GO:0045598 name: regulation of fat cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "regulation of adipocyte cell differentiation" EXACT [] synonym: "regulation of adipocyte differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045444 ! regulates fat cell differentiation relationship: RO:0002211 GO:0045444 ! regulates fat cell differentiation [Term] id: GO:0045599 name: negative regulation of fat cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "down regulation of fat cell differentiation" EXACT [] synonym: "down-regulation of fat cell differentiation" EXACT [] synonym: "downregulation of fat cell differentiation" EXACT [] synonym: "inhibition of fat cell differentiation" NARROW [] synonym: "negative regulation of adipocyte cell differentiation" EXACT [] synonym: "negative regulation of adipocyte differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation relationship: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation [Term] id: GO:0045600 name: positive regulation of fat cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] synonym: "activation of fat cell differentiation" NARROW [] synonym: "positive regulation of adipocyte cell differentiation" EXACT [] synonym: "positive regulation of adipocyte differentiation" EXACT [] synonym: "stimulation of fat cell differentiation" NARROW [] synonym: "up regulation of fat cell differentiation" EXACT [] synonym: "up-regulation of fat cell differentiation" EXACT [] synonym: "upregulation of fat cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045598 ! regulation of fat cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation relationship: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation [Term] id: GO:0045601 name: regulation of endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] is_a: GO:0030856 ! regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation relationship: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation [Term] id: GO:0045602 name: negative regulation of endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "down regulation of endothelial cell differentiation" EXACT [] synonym: "down-regulation of endothelial cell differentiation" EXACT [] synonym: "downregulation of endothelial cell differentiation" EXACT [] synonym: "inhibition of endothelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation relationship: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation [Term] id: GO:0045603 name: positive regulation of endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] synonym: "activation of endothelial cell differentiation" NARROW [] synonym: "stimulation of endothelial cell differentiation" NARROW [] synonym: "up regulation of endothelial cell differentiation" EXACT [] synonym: "up-regulation of endothelial cell differentiation" EXACT [] synonym: "upregulation of endothelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation relationship: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation [Term] id: GO:0045604 name: regulation of epidermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045682 ! regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation relationship: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation [Term] id: GO:0045605 name: negative regulation of epidermal cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "down regulation of epidermal cell differentiation" EXACT [] synonym: "down-regulation of epidermal cell differentiation" EXACT [] synonym: "downregulation of epidermal cell differentiation" EXACT [] synonym: "inhibition of epidermal cell differentiation" NARROW [] synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045683 ! negative regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation relationship: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation [Term] id: GO:0045606 name: positive regulation of epidermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] synonym: "activation of epidermal cell differentiation" NARROW [] synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermal cell differentiation" NARROW [] synonym: "up regulation of epidermal cell differentiation" EXACT [] synonym: "up-regulation of epidermal cell differentiation" EXACT [] synonym: "upregulation of epidermal cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0045604 ! regulation of epidermal cell differentiation is_a: GO:0045684 ! positive regulation of epidermis development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation relationship: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation [Term] id: GO:0045619 name: regulation of lymphocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0051249 ! regulation of lymphocyte activation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030098 ! regulates lymphocyte differentiation relationship: RO:0002211 GO:0030098 ! regulates lymphocyte differentiation [Term] id: GO:0045620 name: negative regulation of lymphocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of lymphocyte differentiation" EXACT [] synonym: "down-regulation of lymphocyte differentiation" EXACT [] synonym: "downregulation of lymphocyte differentiation" EXACT [] synonym: "inhibition of lymphocyte differentiation" NARROW [] synonym: "negative regulation of lymphocyte development" RELATED [GOC:add] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1902106 ! negative regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030098 ! negatively regulates lymphocyte differentiation relationship: RO:0002212 GO:0030098 ! negatively regulates lymphocyte differentiation [Term] id: GO:0045621 name: positive regulation of lymphocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of lymphocyte differentiation" NARROW [] synonym: "positive regulation of lymphocyte development" RELATED [GOC:add] synonym: "stimulation of lymphocyte differentiation" NARROW [] synonym: "up regulation of lymphocyte differentiation" EXACT [] synonym: "up-regulation of lymphocyte differentiation" EXACT [] synonym: "upregulation of lymphocyte differentiation" EXACT [] is_a: GO:0045619 ! regulation of lymphocyte differentiation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1902107 ! positive regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030098 ! positively regulates lymphocyte differentiation relationship: RO:0002213 GO:0030098 ! positively regulates lymphocyte differentiation [Term] id: GO:0045637 name: regulation of myeloid cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8939246 "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells" is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation relationship: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation [Term] id: GO:0045638 name: negative regulation of myeloid cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "down regulation of myeloid cell differentiation" EXACT [] synonym: "down-regulation of myeloid cell differentiation" EXACT [] synonym: "downregulation of myeloid cell differentiation" EXACT [] synonym: "inhibition of myeloid cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation relationship: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation [Term] id: GO:0045639 name: positive regulation of myeloid cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] synonym: "activation of myeloid cell differentiation" NARROW [] synonym: "stimulation of myeloid cell differentiation" NARROW [] synonym: "up regulation of myeloid cell differentiation" EXACT [] synonym: "up-regulation of myeloid cell differentiation" EXACT [] synonym: "upregulation of myeloid cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation relationship: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation [Term] id: GO:0045646 name: regulation of erythrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "regulation of RBC differentiation" EXACT [CL:0000232] synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation relationship: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation [Term] id: GO:0045647 name: negative regulation of erythrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "down regulation of erythrocyte differentiation" EXACT [] synonym: "down-regulation of erythrocyte differentiation" EXACT [] synonym: "downregulation of erythrocyte differentiation" EXACT [] synonym: "inhibition of erythrocyte differentiation" NARROW [] synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation relationship: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation [Term] id: GO:0045648 name: positive regulation of erythrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] synonym: "activation of erythrocyte differentiation" NARROW [] synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] synonym: "stimulation of erythrocyte differentiation" NARROW [] synonym: "up regulation of erythrocyte differentiation" EXACT [] synonym: "up-regulation of erythrocyte differentiation" EXACT [] synonym: "upregulation of erythrocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045646 ! regulation of erythrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation relationship: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation [Term] id: GO:0045649 name: regulation of macrophage differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030225 ! regulates macrophage differentiation relationship: RO:0002211 GO:0030225 ! regulates macrophage differentiation [Term] id: GO:0045650 name: negative regulation of macrophage differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "down regulation of macrophage differentiation" EXACT [] synonym: "down-regulation of macrophage differentiation" EXACT [] synonym: "downregulation of macrophage differentiation" EXACT [] synonym: "inhibition of macrophage differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030225 ! negatively regulates macrophage differentiation relationship: RO:0002212 GO:0030225 ! negatively regulates macrophage differentiation [Term] id: GO:0045651 name: positive regulation of macrophage differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] synonym: "activation of macrophage differentiation" NARROW [] synonym: "stimulation of macrophage differentiation" NARROW [] synonym: "up regulation of macrophage differentiation" EXACT [] synonym: "up-regulation of macrophage differentiation" EXACT [] synonym: "upregulation of macrophage differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045649 ! regulation of macrophage differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030225 ! positively regulates macrophage differentiation relationship: RO:0002213 GO:0030225 ! positively regulates macrophage differentiation [Term] id: GO:0045652 name: regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] xref: Reactome:R-HSA-8936459 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation relationship: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation [Term] id: GO:0045653 name: negative regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "down regulation of megakaryocyte differentiation" EXACT [] synonym: "down-regulation of megakaryocyte differentiation" EXACT [] synonym: "downregulation of megakaryocyte differentiation" EXACT [] synonym: "inhibition of megakaryocyte differentiation" NARROW [] is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation relationship: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation [Term] id: GO:0045654 name: positive regulation of megakaryocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] synonym: "activation of megakaryocyte differentiation" NARROW [] synonym: "stimulation of megakaryocyte differentiation" NARROW [] synonym: "up regulation of megakaryocyte differentiation" EXACT [] synonym: "up-regulation of megakaryocyte differentiation" EXACT [] synonym: "upregulation of megakaryocyte differentiation" EXACT [] is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:0045652 ! regulation of megakaryocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation relationship: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation [Term] id: GO:0045655 name: regulation of monocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030224 ! regulates monocyte differentiation relationship: RO:0002211 GO:0030224 ! regulates monocyte differentiation [Term] id: GO:0045656 name: negative regulation of monocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "down regulation of monocyte differentiation" EXACT [] synonym: "down-regulation of monocyte differentiation" EXACT [] synonym: "downregulation of monocyte differentiation" EXACT [] synonym: "inhibition of monocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030224 ! negatively regulates monocyte differentiation relationship: RO:0002212 GO:0030224 ! negatively regulates monocyte differentiation [Term] id: GO:0045657 name: positive regulation of monocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] synonym: "activation of monocyte differentiation" NARROW [] synonym: "stimulation of monocyte differentiation" NARROW [] synonym: "up regulation of monocyte differentiation" EXACT [] synonym: "up-regulation of monocyte differentiation" EXACT [] synonym: "upregulation of monocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045655 ! regulation of monocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030224 ! positively regulates monocyte differentiation relationship: RO:0002213 GO:0030224 ! positively regulates monocyte differentiation [Term] id: GO:0045661 name: regulation of myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045445 ! regulates myoblast differentiation relationship: RO:0002211 GO:0045445 ! regulates myoblast differentiation [Term] id: GO:0045662 name: negative regulation of myoblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "down regulation of myoblast differentiation" EXACT [] synonym: "down-regulation of myoblast differentiation" EXACT [] synonym: "downregulation of myoblast differentiation" EXACT [] synonym: "inhibition of myoblast differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation relationship: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation [Term] id: GO:0045663 name: positive regulation of myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] synonym: "activation of myoblast differentiation" NARROW [] synonym: "stimulation of myoblast differentiation" NARROW [] synonym: "up regulation of myoblast differentiation" EXACT [] synonym: "up-regulation of myoblast differentiation" EXACT [] synonym: "upregulation of myoblast differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045661 ! regulation of myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation relationship: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation [Term] id: GO:0045664 name: regulation of neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030182 ! regulates neuron differentiation relationship: RO:0002211 GO:0030182 ! regulates neuron differentiation [Term] id: GO:0045665 name: negative regulation of neuron differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "down regulation of neuron differentiation" EXACT [] synonym: "down-regulation of neuron differentiation" EXACT [] synonym: "downregulation of neuron differentiation" EXACT [] synonym: "inhibition of neuron differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation relationship: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation [Term] id: GO:0045666 name: positive regulation of neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] synonym: "activation of neuron differentiation" NARROW [] synonym: "stimulation of neuron differentiation" NARROW [] synonym: "up regulation of neuron differentiation" EXACT [] synonym: "up-regulation of neuron differentiation" EXACT [] synonym: "upregulation of neuron differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030182 ! positively regulates neuron differentiation relationship: RO:0002213 GO:0030182 ! positively regulates neuron differentiation [Term] id: GO:0045670 name: regulation of osteoclast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030316 ! regulates osteoclast differentiation relationship: RO:0002211 GO:0030316 ! regulates osteoclast differentiation [Term] id: GO:0045671 name: negative regulation of osteoclast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "down regulation of osteoclast differentiation" EXACT [] synonym: "down-regulation of osteoclast differentiation" EXACT [] synonym: "downregulation of osteoclast differentiation" EXACT [] synonym: "inhibition of osteoclast differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030316 ! negatively regulates osteoclast differentiation relationship: RO:0002212 GO:0030316 ! negatively regulates osteoclast differentiation [Term] id: GO:0045672 name: positive regulation of osteoclast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] synonym: "activation of osteoclast differentiation" NARROW [] synonym: "stimulation of osteoclast differentiation" NARROW [] synonym: "up regulation of osteoclast differentiation" EXACT [] synonym: "up-regulation of osteoclast differentiation" EXACT [] synonym: "upregulation of osteoclast differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0045670 ! regulation of osteoclast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030316 ! positively regulates osteoclast differentiation relationship: RO:0002213 GO:0030316 ! positively regulates osteoclast differentiation [Term] id: GO:0045682 name: regulation of epidermis development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "regulation of epidermal development" EXACT [] synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008544 ! regulates epidermis development relationship: RO:0002211 GO:0008544 ! regulates epidermis development [Term] id: GO:0045683 name: negative regulation of epidermis development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "down regulation of epidermis development" EXACT [] synonym: "down-regulation of epidermis development" EXACT [] synonym: "downregulation of epidermis development" EXACT [] synonym: "inhibition of epidermis development" NARROW [] synonym: "negative regulation of epidermal development" EXACT [] synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008544 ! negatively regulates epidermis development relationship: RO:0002212 GO:0008544 ! negatively regulates epidermis development [Term] id: GO:0045684 name: positive regulation of epidermis development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] synonym: "activation of epidermis development" NARROW [] synonym: "positive regulation of epidermal development" EXACT [] synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] synonym: "stimulation of epidermis development" NARROW [] synonym: "up regulation of epidermis development" EXACT [] synonym: "up-regulation of epidermis development" EXACT [] synonym: "upregulation of epidermis development" EXACT [] is_a: GO:0045682 ! regulation of epidermis development is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008544 ! positively regulates epidermis development relationship: RO:0002213 GO:0008544 ! positively regulates epidermis development [Term] id: GO:0045685 name: regulation of glial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "regulation of glia cell differentiation" EXACT [] synonym: "regulation of neuroglia differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010001 ! regulates glial cell differentiation relationship: RO:0002211 GO:0010001 ! regulates glial cell differentiation [Term] id: GO:0045686 name: negative regulation of glial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "down regulation of glial cell differentiation" EXACT [] synonym: "down-regulation of glial cell differentiation" EXACT [] synonym: "downregulation of glial cell differentiation" EXACT [] synonym: "inhibition of glial cell differentiation" NARROW [] synonym: "negative regulation of glia cell differentiation" EXACT [] synonym: "negative regulation of neuroglia differentiation" EXACT [] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation relationship: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation [Term] id: GO:0045687 name: positive regulation of glial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] synonym: "activation of glial cell differentiation" NARROW [] synonym: "positive regulation of glia cell differentiation" EXACT [] synonym: "positive regulation of neuroglia differentiation" EXACT [] synonym: "stimulation of glial cell differentiation" NARROW [] synonym: "up regulation of glial cell differentiation" EXACT [] synonym: "up-regulation of glial cell differentiation" EXACT [] synonym: "upregulation of glial cell differentiation" EXACT [] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation relationship: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation [Term] id: GO:0045724 name: positive regulation of cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] synonym: "activation of cilium assembly" NARROW [] synonym: "positive regulation of flagellum assembly" BROAD [] synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] synonym: "stimulation of cilium assembly" NARROW [] synonym: "up regulation of cilium assembly" EXACT [] synonym: "up-regulation of cilium assembly" EXACT [] synonym: "upregulation of cilium assembly" EXACT [] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902117 ! positive regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060271 ! positively regulates cilium assembly relationship: RO:0002213 GO:0060271 ! positively regulates cilium assembly [Term] id: GO:0045727 name: positive regulation of translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of protein biosynthetic process" NARROW [] synonym: "positive regulation of protein anabolism" EXACT [] synonym: "positive regulation of protein biosynthesis" EXACT [] synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] synonym: "positive regulation of protein formation" EXACT [] synonym: "positive regulation of protein synthesis" EXACT [] synonym: "stimulation of protein biosynthetic process" NARROW [] synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006412 ! positively regulates translation relationship: RO:0002213 GO:0006412 ! positively regulates translation [Term] id: GO:0045730 name: respiratory burst namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732] synonym: "metabolic burst" EXACT [] synonym: "oxidative burst" EXACT [] xref: Wikipedia:Respiratory_burst is_a: GO:0008152 ! metabolic process [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process" EXACT [] synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] synonym: "positive regulation of cyclin catabolic process" NARROW [] synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030163 ! positively regulates protein catabolic process relationship: RO:0002213 GO:0030163 ! positively regulates protein catabolic process [Term] id: GO:0045744 name: negative regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007186 ! negatively regulates G protein-coupled receptor signaling pathway relationship: RO:0002212 GO:0007186 ! negatively regulates G protein-coupled receptor signaling pathway [Term] id: GO:0045745 name: positive regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007186 ! positively regulates G protein-coupled receptor signaling pathway relationship: RO:0002213 GO:0007186 ! positively regulates G protein-coupled receptor signaling pathway [Term] id: GO:0045759 name: negative regulation of action potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "down regulation of action potential" EXACT [] synonym: "down-regulation of action potential" EXACT [] synonym: "downregulation of action potential" EXACT [] synonym: "inhibition of action potential" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001508 ! negatively regulates action potential relationship: RO:0002212 GO:0001508 ! negatively regulates action potential [Term] id: GO:0045760 name: positive regulation of action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] synonym: "activation of action potential" NARROW [] synonym: "stimulation of action potential" NARROW [] synonym: "up regulation of action potential" EXACT [] synonym: "up-regulation of action potential" EXACT [] synonym: "upregulation of action potential" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001508 ! positively regulates action potential relationship: RO:0002213 GO:0001508 ! positively regulates action potential [Term] id: GO:0045763 name: negative regulation of amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "down regulation of amino acid metabolic process" EXACT [] synonym: "down-regulation of amino acid metabolic process" EXACT [] synonym: "downregulation of amino acid metabolic process" EXACT [] synonym: "inhibition of amino acid metabolic process" NARROW [] synonym: "negative regulation of amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process relationship: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process [Term] id: GO:0045764 name: positive regulation of amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] synonym: "activation of amino acid metabolic process" NARROW [] synonym: "positive regulation of amino acid metabolism" EXACT [] synonym: "positive regulation of cellular amino acid metabolic process" EXACT [] synonym: "stimulation of amino acid metabolic process" NARROW [] synonym: "up regulation of amino acid metabolic process" EXACT [] synonym: "up-regulation of amino acid metabolic process" EXACT [] synonym: "upregulation of amino acid metabolic process" EXACT [] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process relationship: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process [Term] id: GO:0045765 name: regulation of angiogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001525 ! regulates angiogenesis relationship: RO:0002211 GO:0001525 ! regulates angiogenesis [Term] id: GO:0045766 name: positive regulation of angiogenesis namespace: biological_process def: "Any process that activates or increases angiogenesis." [GOC:go_curators] synonym: "activation of angiogenesis" NARROW [] synonym: "stimulation of angiogenesis" NARROW [] synonym: "up regulation of angiogenesis" EXACT [] synonym: "up-regulation of angiogenesis" EXACT [] synonym: "upregulation of angiogenesis" EXACT [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:1904018 ! positive regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001525 ! positively regulates angiogenesis relationship: RO:0002213 GO:0001525 ! positively regulates angiogenesis [Term] id: GO:0045769 name: negative regulation of asymmetric cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "down regulation of asymmetric cell division" EXACT [] synonym: "down-regulation of asymmetric cell division" EXACT [] synonym: "downregulation of asymmetric cell division" EXACT [] synonym: "inhibition of asymmetric cell division" NARROW [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051782 ! negative regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division relationship: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division [Term] id: GO:0045770 name: positive regulation of asymmetric cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] synonym: "activation of asymmetric cell division" NARROW [] synonym: "stimulation of asymmetric cell division" NARROW [] synonym: "up regulation of asymmetric cell division" EXACT [] synonym: "up-regulation of asymmetric cell division" EXACT [] synonym: "upregulation of asymmetric cell division" EXACT [] is_a: GO:0009786 ! regulation of asymmetric cell division is_a: GO:0051781 ! positive regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division relationship: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division [Term] id: GO:0045778 name: positive regulation of ossification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "activation of ossification" NARROW [] synonym: "positive regulation of bone biosynthesis" EXACT [] synonym: "positive regulation of bone formation" EXACT [] synonym: "stimulation of ossification" NARROW [] synonym: "up regulation of ossification" EXACT [] synonym: "up-regulation of ossification" EXACT [] synonym: "upregulation of ossification" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001503 ! positively regulates ossification relationship: RO:0002213 GO:0001503 ! positively regulates ossification [Term] id: GO:0045779 name: negative regulation of bone resorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "down regulation of bone resorption" EXACT [] synonym: "down-regulation of bone resorption" EXACT [] synonym: "downregulation of bone resorption" EXACT [] synonym: "inhibition of bone resorption" NARROW [] is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0046851 ! negative regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045453 ! negatively regulates bone resorption relationship: RO:0002212 GO:0045453 ! negatively regulates bone resorption [Term] id: GO:0045780 name: positive regulation of bone resorption namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators] synonym: "activation of bone resorption" NARROW [] synonym: "stimulation of bone resorption" NARROW [] synonym: "up regulation of bone resorption" EXACT [] synonym: "up-regulation of bone resorption" EXACT [] synonym: "upregulation of bone resorption" EXACT [] is_a: GO:0045124 ! regulation of bone resorption is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045453 ! positively regulates bone resorption relationship: RO:0002213 GO:0045453 ! positively regulates bone resorption [Term] id: GO:0045785 name: positive regulation of cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "activation of cell adhesion" NARROW [] synonym: "stimulation of cell adhesion" NARROW [] synonym: "up regulation of cell adhesion" EXACT [] synonym: "up-regulation of cell adhesion" EXACT [] synonym: "upregulation of cell adhesion" EXACT [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007155 ! positively regulates cell adhesion relationship: RO:0002213 GO:0007155 ! positively regulates cell adhesion [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] xref: Reactome:R-HSA-193670 "p75NTR negatively regulates cell cycle via SC1" is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007049 ! negatively regulates cell cycle relationship: RO:0002212 GO:0007049 ! negatively regulates cell cycle [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] xref: Reactome:R-HSA-8849470 "PTK6 Regulates Cell Cycle" is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007049 ! positively regulates cell cycle relationship: RO:0002213 GO:0007049 ! positively regulates cell cycle [Term] id: GO:0045806 name: negative regulation of endocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "down regulation of endocytosis" EXACT [] synonym: "down-regulation of endocytosis" EXACT [] synonym: "downregulation of endocytosis" EXACT [] synonym: "inhibition of endocytosis" NARROW [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006897 ! negatively regulates endocytosis relationship: RO:0002212 GO:0006897 ! negatively regulates endocytosis [Term] id: GO:0045807 name: positive regulation of endocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] synonym: "activation of endocytosis" NARROW [] synonym: "stimulation of endocytosis" NARROW [] synonym: "up regulation of endocytosis" EXACT [] synonym: "up-regulation of endocytosis" EXACT [] synonym: "upregulation of endocytosis" EXACT [] is_a: GO:0030100 ! regulation of endocytosis is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006897 ! positively regulates endocytosis relationship: RO:0002213 GO:0006897 ! positively regulates endocytosis [Term] id: GO:0045822 name: negative regulation of heart contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "down regulation of heart contraction" EXACT [] synonym: "down-regulation of heart contraction" EXACT [] synonym: "downregulation of heart contraction" EXACT [] synonym: "inhibition of heart contraction" NARROW [] synonym: "negative regulation of cardiac contraction" RELATED [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060047 ! negatively regulates heart contraction relationship: RO:0002212 GO:0060047 ! negatively regulates heart contraction [Term] id: GO:0045823 name: positive regulation of heart contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] synonym: "activation of heart contraction" NARROW [] synonym: "positive regulation of cardiac contraction" EXACT [] synonym: "stimulation of heart contraction" NARROW [] synonym: "up regulation of heart contraction" EXACT [] synonym: "up-regulation of heart contraction" EXACT [] synonym: "upregulation of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060047 ! positively regulates heart contraction relationship: RO:0002213 GO:0060047 ! positively regulates heart contraction [Term] id: GO:0045824 name: negative regulation of innate immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] synonym: "down regulation of innate immune response" EXACT [] synonym: "down-regulation of innate immune response" EXACT [] synonym: "downregulation of innate immune response" EXACT [] synonym: "inhibition of innate immune response" NARROW [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045087 ! negatively regulates innate immune response relationship: RO:0002212 GO:0045087 ! negatively regulates innate immune response [Term] id: GO:0045833 name: negative regulation of lipid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "down regulation of lipid metabolic process" EXACT [] synonym: "down-regulation of lipid metabolic process" EXACT [] synonym: "downregulation of lipid metabolic process" EXACT [] synonym: "inhibition of lipid metabolic process" NARROW [] synonym: "negative regulation of lipid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process relationship: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process [Term] id: GO:0045834 name: positive regulation of lipid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "activation of lipid metabolic process" NARROW [] synonym: "positive regulation of lipid metabolism" EXACT [] synonym: "stimulation of lipid metabolic process" NARROW [] synonym: "up regulation of lipid metabolic process" EXACT [] synonym: "up-regulation of lipid metabolic process" EXACT [] synonym: "upregulation of lipid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process relationship: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process [Term] id: GO:0045835 name: negative regulation of meiotic nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "down regulation of meiosis" EXACT [] synonym: "down-regulation of meiosis" EXACT [] synonym: "downregulation of meiosis" EXACT [] synonym: "inhibition of meiosis" NARROW [] synonym: "negative regulation of meiosis" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division relationship: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division [Term] id: GO:0045836 name: positive regulation of meiotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] synonym: "activation of meiosis" NARROW [] synonym: "positive regulation of meiosis" EXACT [] synonym: "stimulation of meiosis" NARROW [] synonym: "up regulation of meiosis" EXACT [] synonym: "up-regulation of meiosis" EXACT [] synonym: "upregulation of meiosis" EXACT [] is_a: GO:0040020 ! regulation of meiotic nuclear division is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division relationship: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division relationship: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division relationship: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division [Term] id: GO:0045843 name: negative regulation of striated muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "down regulation of striated muscle development" EXACT [] synonym: "down-regulation of striated muscle development" EXACT [] synonym: "downregulation of striated muscle development" EXACT [] synonym: "inhibition of striated muscle development" NARROW [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048635 ! negative regulation of muscle organ development is_a: GO:1901862 ! negative regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development relationship: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development [Term] id: GO:0045844 name: positive regulation of striated muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] synonym: "activation of striated muscle development" NARROW [] synonym: "stimulation of striated muscle development" NARROW [] synonym: "up regulation of striated muscle development" EXACT [] synonym: "up-regulation of striated muscle development" EXACT [] synonym: "upregulation of striated muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development is_a: GO:0048636 ! positive regulation of muscle organ development is_a: GO:1901863 ! positive regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development relationship: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development [Term] id: GO:0045900 name: negative regulation of translational elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "down regulation of translational elongation" EXACT [] synonym: "down-regulation of translational elongation" EXACT [] synonym: "downregulation of translational elongation" EXACT [] synonym: "inhibition of translational elongation" NARROW [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006414 ! negatively regulates translational elongation relationship: RO:0002212 GO:0006414 ! negatively regulates translational elongation [Term] id: GO:0045901 name: positive regulation of translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] synonym: "activation of translational elongation" NARROW [] synonym: "stimulation of translational elongation" NARROW [] synonym: "up regulation of translational elongation" EXACT [] synonym: "up-regulation of translational elongation" EXACT [] synonym: "upregulation of translational elongation" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006414 ! positively regulates translational elongation relationship: RO:0002213 GO:0006414 ! positively regulates translational elongation [Term] id: GO:0045904 name: negative regulation of translational termination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "down regulation of translational termination" EXACT [] synonym: "down-regulation of translational termination" EXACT [] synonym: "downregulation of translational termination" EXACT [] synonym: "inhibition of translational termination" NARROW [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006415 ! negatively regulates translational termination relationship: RO:0002212 GO:0006415 ! negatively regulates translational termination [Term] id: GO:0045905 name: positive regulation of translational termination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] synonym: "activation of translational termination" NARROW [] synonym: "stimulation of translational termination" NARROW [] synonym: "up regulation of translational termination" EXACT [] synonym: "up-regulation of translational termination" EXACT [] synonym: "upregulation of translational termination" EXACT [] is_a: GO:0006449 ! regulation of translational termination is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006415 ! positively regulates translational termination relationship: RO:0002213 GO:0006415 ! positively regulates translational termination [Term] id: GO:0045912 name: negative regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "down regulation of carbohydrate metabolic process" EXACT [] synonym: "down-regulation of carbohydrate metabolic process" EXACT [] synonym: "downregulation of carbohydrate metabolic process" EXACT [] synonym: "inhibition of carbohydrate metabolic process" NARROW [] synonym: "negative regulation of carbohydrate metabolism" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process relationship: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process [Term] id: GO:0045913 name: positive regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] synonym: "activation of carbohydrate metabolic process" NARROW [] synonym: "positive regulation of carbohydrate metabolism" EXACT [] synonym: "stimulation of carbohydrate metabolic process" NARROW [] synonym: "up regulation of carbohydrate metabolic process" EXACT [] synonym: "up-regulation of carbohydrate metabolic process" EXACT [] synonym: "upregulation of carbohydrate metabolic process" EXACT [] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process relationship: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process [Term] id: GO:0045914 name: negative regulation of catecholamine metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] synonym: "down regulation of catecholamine metabolic process" EXACT [] synonym: "down-regulation of catecholamine metabolic process" EXACT [] synonym: "downregulation of catecholamine metabolic process" EXACT [] synonym: "inhibition of catecholamine metabolic process" NARROW [] synonym: "negative regulation of catecholamine metabolism" EXACT [] is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006584 ! negatively regulates catecholamine metabolic process relationship: RO:0002212 GO:0006584 ! negatively regulates catecholamine metabolic process [Term] id: GO:0045915 name: positive regulation of catecholamine metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] synonym: "activation of catecholamine metabolic process" NARROW [] synonym: "positive regulation of catecholamine metabolism" EXACT [] synonym: "stimulation of catecholamine metabolic process" NARROW [] synonym: "up regulation of catecholamine metabolic process" EXACT [] synonym: "up-regulation of catecholamine metabolic process" EXACT [] synonym: "upregulation of catecholamine metabolic process" EXACT [] is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0042069 ! regulation of catecholamine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006584 ! positively regulates catecholamine metabolic process relationship: RO:0002213 GO:0006584 ! positively regulates catecholamine metabolic process [Term] id: GO:0045920 name: negative regulation of exocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "down regulation of exocytosis" EXACT [] synonym: "down-regulation of exocytosis" EXACT [] synonym: "downregulation of exocytosis" EXACT [] synonym: "inhibition of exocytosis" NARROW [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006887 ! negatively regulates exocytosis relationship: RO:0002212 GO:0006887 ! negatively regulates exocytosis [Term] id: GO:0045921 name: positive regulation of exocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] synonym: "activation of exocytosis" NARROW [] synonym: "stimulation of exocytosis" NARROW [] synonym: "up regulation of exocytosis" EXACT [] synonym: "up-regulation of exocytosis" EXACT [] synonym: "upregulation of exocytosis" EXACT [] is_a: GO:0017157 ! regulation of exocytosis is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006887 ! positively regulates exocytosis relationship: RO:0002213 GO:0006887 ! positively regulates exocytosis [Term] id: GO:0045926 name: negative regulation of growth namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "down regulation of growth" EXACT [] synonym: "down-regulation of growth" EXACT [] synonym: "downregulation of growth" EXACT [] synonym: "inhibition of growth" NARROW [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0040007 ! negatively regulates growth relationship: RO:0002212 GO:0040007 ! negatively regulates growth [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0040007 ! positively regulates growth relationship: RO:0002213 GO:0040007 ! positively regulates growth [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:R-HSA-8854050 "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis" is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle relationship: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle relationship: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle [Term] id: GO:0045932 name: negative regulation of muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "down regulation of muscle contraction" EXACT [] synonym: "down-regulation of muscle contraction" EXACT [] synonym: "downregulation of muscle contraction" EXACT [] synonym: "inhibition of muscle contraction" NARROW [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006936 ! negatively regulates muscle contraction relationship: RO:0002212 GO:0006936 ! negatively regulates muscle contraction [Term] id: GO:0045933 name: positive regulation of muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] synonym: "activation of muscle contraction" NARROW [] synonym: "stimulation of muscle contraction" NARROW [] synonym: "up regulation of muscle contraction" EXACT [] synonym: "up-regulation of muscle contraction" EXACT [] synonym: "upregulation of muscle contraction" EXACT [] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006936 ! positively regulates muscle contraction relationship: RO:0002213 GO:0006936 ! positively regulates muscle contraction [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process relationship: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006139 ! positively regulates nucleobase-containing compound metabolic process relationship: RO:0002213 GO:0006139 ! positively regulates nucleobase-containing compound metabolic process [Term] id: GO:0045936 name: negative regulation of phosphate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "down regulation of phosphate metabolic process" EXACT [] synonym: "down-regulation of phosphate metabolic process" EXACT [] synonym: "downregulation of phosphate metabolic process" EXACT [] synonym: "inhibition of phosphate metabolic process" NARROW [] synonym: "negative regulation of phosphate metabolism" EXACT [] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006796 ! negatively regulates phosphate-containing compound metabolic process relationship: RO:0002212 GO:0006796 ! negatively regulates phosphate-containing compound metabolic process [Term] id: GO:0045937 name: positive regulation of phosphate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "activation of phosphate metabolic process" NARROW [] synonym: "positive regulation of phosphate metabolism" EXACT [] synonym: "stimulation of phosphate metabolic process" NARROW [] synonym: "up regulation of phosphate metabolic process" EXACT [] synonym: "up-regulation of phosphate metabolic process" EXACT [] synonym: "upregulation of phosphate metabolic process" EXACT [] is_a: GO:0010562 ! positive regulation of phosphorus metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006796 ! positively regulates phosphate-containing compound metabolic process relationship: RO:0002213 GO:0006796 ! positively regulates phosphate-containing compound metabolic process [Term] id: GO:0045939 name: negative regulation of steroid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "down regulation of steroid metabolic process" EXACT [] synonym: "down-regulation of steroid metabolic process" EXACT [] synonym: "downregulation of steroid metabolic process" EXACT [] synonym: "inhibition of steroid metabolic process" NARROW [] synonym: "negative regulation of steroid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process relationship: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process [Term] id: GO:0045940 name: positive regulation of steroid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "activation of steroid metabolic process" NARROW [] synonym: "positive regulation of steroid metabolism" EXACT [] synonym: "stimulation of steroid metabolic process" NARROW [] synonym: "up regulation of steroid metabolic process" EXACT [] synonym: "up-regulation of steroid metabolic process" EXACT [] synonym: "upregulation of steroid metabolic process" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process relationship: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process [Term] id: GO:0045947 name: negative regulation of translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "down regulation of translational initiation" EXACT [] synonym: "down-regulation of translational initiation" EXACT [] synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation relationship: RO:0002212 GO:0006413 ! negatively regulates translational initiation [Term] id: GO:0045948 name: positive regulation of translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] synonym: "activation of translational initiation" NARROW [] synonym: "stimulation of translational initiation" NARROW [] synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation relationship: RO:0002213 GO:0006413 ! positively regulates translational initiation [Term] id: GO:0045986 name: negative regulation of smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "down regulation of smooth muscle contraction" EXACT [] synonym: "down-regulation of smooth muscle contraction" EXACT [] synonym: "downregulation of smooth muscle contraction" EXACT [] synonym: "inhibition of smooth muscle contraction" NARROW [] synonym: "smooth muscle relaxation" RELATED [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction relationship: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction [Term] id: GO:0045987 name: positive regulation of smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] synonym: "activation of smooth muscle contraction" NARROW [] synonym: "stimulation of smooth muscle contraction" NARROW [] synonym: "up regulation of smooth muscle contraction" EXACT [] synonym: "up-regulation of smooth muscle contraction" EXACT [] synonym: "upregulation of smooth muscle contraction" EXACT [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction relationship: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction [Term] id: GO:0045988 name: negative regulation of striated muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "down regulation of striated muscle contraction" EXACT [] synonym: "down-regulation of striated muscle contraction" EXACT [] synonym: "downregulation of striated muscle contraction" EXACT [] synonym: "inhibition of striated muscle contraction" NARROW [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045932 ! negative regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction relationship: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction [Term] id: GO:0045989 name: positive regulation of striated muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] synonym: "activation of striated muscle contraction" NARROW [] synonym: "stimulation of striated muscle contraction" NARROW [] synonym: "up regulation of striated muscle contraction" EXACT [] synonym: "up-regulation of striated muscle contraction" EXACT [] synonym: "upregulation of striated muscle contraction" EXACT [] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0045933 ! positive regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction relationship: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction [Term] id: GO:0045992 name: negative regulation of embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] synonym: "down regulation of embryonic development" EXACT [] synonym: "down-regulation of embryonic development" EXACT [] synonym: "downregulation of embryonic development" EXACT [] synonym: "inhibition of embryonic development" NARROW [] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009790 ! negatively regulates embryo development relationship: RO:0002212 GO:0009790 ! negatively regulates embryo development [Term] id: GO:0045995 name: regulation of embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009790 ! regulates embryo development relationship: RO:0002211 GO:0009790 ! regulates embryo development [Term] id: GO:0046013 name: regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "regulation of resting T cell proliferation" EXACT [] synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "regulation of T-cell homeostatic proliferation" EXACT [] synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042129 ! regulation of T cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001777 ! regulates T cell homeostatic proliferation relationship: RO:0002211 GO:0001777 ! regulates T cell homeostatic proliferation [Term] id: GO:0046014 name: negative regulation of T cell homeostatic proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators] synonym: "down regulation of T cell homeostatic proliferation" EXACT [] synonym: "down-regulation of T cell homeostatic proliferation" EXACT [] synonym: "downregulation of T cell homeostatic proliferation" EXACT [] synonym: "inhibition of T cell homeostatic proliferation" NARROW [] synonym: "negative regulation of resting T cell proliferation" EXACT [] synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT [] synonym: "negative regulation of T-cell homeostatic proliferation" EXACT [] synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042130 ! negative regulation of T cell proliferation is_a: GO:0046013 ! regulation of T cell homeostatic proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001777 ! negatively regulates T cell homeostatic proliferation relationship: RO:0002212 GO:0001777 ! negatively regulates T cell homeostatic proliferation [Term] id: GO:0046112 name: nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] synonym: "nucleobase anabolism" EXACT [] synonym: "nucleobase biosynthesis" EXACT [] synonym: "nucleobase formation" EXACT [] synonym: "nucleobase synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0009112 ! nucleobase metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18282 ! has primary output nucleobase relationship: RO:0004008 CHEBI:18282 ! has primary output nucleobase [Term] id: GO:0046165 name: alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] synonym: "alcohol anabolism" EXACT [] synonym: "alcohol biosynthesis" EXACT [] synonym: "alcohol formation" EXACT [] synonym: "alcohol synthesis" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0046173 name: polyol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators] synonym: "polyhydric alcohol biosynthetic process" EXACT [] synonym: "polyol anabolism" EXACT [] synonym: "polyol biosynthesis" EXACT [] synonym: "polyol formation" EXACT [] synonym: "polyol synthesis" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0046189 name: phenol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai] synonym: "phenol-containing compound anabolism" EXACT [] synonym: "phenol-containing compound biosynthesis" EXACT [] synonym: "phenol-containing compound formation" EXACT [] synonym: "phenol-containing compound synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0018958 ! phenol-containing compound metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33853 ! has primary output phenols relationship: RO:0004008 CHEBI:33853 ! has primary output phenols [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:29067 ! has primary output carboxylic acid anion relationship: RO:0004008 CHEBI:29067 ! has primary output carboxylic acid anion [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0046466 name: membrane lipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid breakdown" EXACT [] synonym: "membrane lipid catabolism" EXACT [] synonym: "membrane lipid degradation" EXACT [] synonym: "membrane lipid peroxidation" BROAD [GOC:tb] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid [Term] id: GO:0046467 name: membrane lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid anabolism" EXACT [] synonym: "membrane lipid biosynthesis" EXACT [] synonym: "membrane lipid formation" EXACT [] synonym: "membrane lipid synthesis" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane intersection_of: RO:0004008 CHEBI:18059 ! has primary output lipid [Term] id: GO:0046530 name: photoreceptor cell differentiation namespace: biological_process def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell relationship: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell [Term] id: GO:0046532 name: regulation of photoreceptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation relationship: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation [Term] id: GO:0046533 name: negative regulation of photoreceptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "down regulation of photoreceptor cell differentiation" EXACT [] synonym: "down regulation of photoreceptor differentiation" EXACT [] synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] synonym: "down-regulation of photoreceptor differentiation" EXACT [] synonym: "downregulation of photoreceptor cell differentiation" EXACT [] synonym: "downregulation of photoreceptor differentiation" EXACT [] synonym: "inhibition of photoreceptor cell differentiation" NARROW [] synonym: "inhibition of photoreceptor differentiation" NARROW [] synonym: "negative regulation of photoreceptor differentiation" EXACT [] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation relationship: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation [Term] id: GO:0046534 name: positive regulation of photoreceptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] synonym: "activation of photoreceptor cell differentiation" NARROW [] synonym: "activation of photoreceptor differentiation" NARROW [] synonym: "positive regulation of photoreceptor differentiation" EXACT [] synonym: "stimulation of photoreceptor cell differentiation" NARROW [] synonym: "stimulation of photoreceptor differentiation" NARROW [] synonym: "up regulation of photoreceptor cell differentiation" EXACT [] synonym: "up regulation of photoreceptor differentiation" EXACT [] synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] synonym: "up-regulation of photoreceptor differentiation" EXACT [] synonym: "upregulation of photoreceptor cell differentiation" EXACT [] synonym: "upregulation of photoreceptor differentiation" EXACT [] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0046532 ! regulation of photoreceptor cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation relationship: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation [Term] id: GO:0046545 name: development of primary female sexual characteristics namespace: biological_process def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] is_a: GO:0045137 ! development of primary sexual characteristics relationship: BFO:0000050 GO:0046660 ! part of female sex differentiation [Term] id: GO:0046548 name: retinal rod cell development namespace: biological_process def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000604 ! results in development of retinal rod cell relationship: BFO:0000050 GO:0060221 ! part of retinal rod cell differentiation relationship: RO:0002296 CL:0000604 ! results in development of retinal rod cell [Term] id: GO:0046549 name: retinal cone cell development namespace: biological_process def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732] is_a: GO:0042462 ! eye photoreceptor cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000573 ! results in development of retinal cone cell relationship: BFO:0000050 GO:0042670 ! part of retinal cone cell differentiation relationship: RO:0002296 CL:0000573 ! results in development of retinal cone cell [Term] id: GO:0046620 name: regulation of organ growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035265 ! regulates organ growth relationship: RO:0002211 GO:0035265 ! regulates organ growth [Term] id: GO:0046621 name: negative regulation of organ growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035265 ! negatively regulates organ growth relationship: RO:0002212 GO:0035265 ! negatively regulates organ growth [Term] id: GO:0046622 name: positive regulation of organ growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035265 ! positively regulates organ growth relationship: RO:0002213 GO:0035265 ! positively regulates organ growth [Term] id: GO:0046649 name: lymphocyte activation namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000542 ! has primary input lymphocyte relationship: RO:0004009 CL:0000542 ! has primary input lymphocyte [Term] id: GO:0046651 name: lymphocyte proliferation namespace: biological_process def: "The expansion of a lymphocyte population by cell division." [GOC:ai] is_a: GO:0032943 ! mononuclear cell proliferation is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte [Term] id: GO:0046660 name: female sex differentiation namespace: biological_process def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] is_a: GO:0007548 ! sex differentiation relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development [Term] id: GO:0046666 name: retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the developing retina." [GOC:bf] synonym: "programmed cell death, retina cells" EXACT [] synonym: "programmed cell death, retinal cells" EXACT [] synonym: "retina cell programmed cell death" EXACT [] synonym: "retina programmed cell death" EXACT [] synonym: "retinal programmed cell death" EXACT [] is_a: GO:0010623 ! programmed cell death involved in cell development relationship: BFO:0000050 GO:0048592 ! part of eye morphogenesis [Term] id: GO:0046667 name: compound eye retinal cell programmed cell death namespace: biological_process def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] is_a: GO:0046666 ! retinal cell programmed cell death intersection_of: GO:0046666 ! retinal cell programmed cell death intersection_of: RO:0002299 UBERON:0000018 ! results in maturation of compound eye relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis relationship: RO:0002299 UBERON:0000018 ! results in maturation of compound eye [Term] id: GO:0046668 name: regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death relationship: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death [Term] id: GO:0046669 name: regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046668 ! regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death relationship: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death [Term] id: GO:0046670 name: positive regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "activation of retinal programmed cell death" NARROW [] synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] synonym: "stimulation of retinal programmed cell death" NARROW [] synonym: "up regulation of retinal programmed cell death" EXACT [] synonym: "up-regulation of retinal programmed cell death" EXACT [] synonym: "upregulation of retinal programmed cell death" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death relationship: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death [Term] id: GO:0046671 name: negative regulation of retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] synonym: "down regulation of retinal programmed cell death" EXACT [] synonym: "down-regulation of retinal programmed cell death" EXACT [] synonym: "downregulation of retinal programmed cell death" EXACT [] synonym: "inhibition of retinal programmed cell death" NARROW [] synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] is_a: GO:0043069 ! negative regulation of programmed cell death is_a: GO:0046668 ! regulation of retinal cell programmed cell death is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death relationship: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death [Term] id: GO:0046672 name: positive regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "activation of retinal cell programmed cell death" BROAD [] synonym: "positive regulation of retinal cell programmed cell death" BROAD [] synonym: "stimulation of retinal cell programmed cell death" BROAD [] synonym: "up regulation of retinal cell programmed cell death" BROAD [] synonym: "up-regulation of retinal cell programmed cell death" BROAD [] synonym: "upregulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death relationship: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death [Term] id: GO:0046673 name: negative regulation of compound eye retinal cell programmed cell death namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] synonym: "down regulation of retinal cell programmed cell death" BROAD [] synonym: "down-regulation of retinal cell programmed cell death" BROAD [] synonym: "downregulation of retinal cell programmed cell death" BROAD [] synonym: "inhibition of retinal cell programmed cell death" BROAD [] synonym: "negative regulation of retina cell programmed cell death" BROAD [] synonym: "negative regulation of retinal cell programmed cell death" BROAD [] is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death relationship: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death [Term] id: GO:0046716 name: muscle cell cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb] synonym: "muscle homeostasis" RELATED [GOC:dph] is_a: GO:0019725 ! cellular homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell [Term] id: GO:0046717 name: acid secretion namespace: biological_process def: "The controlled release of acid by a cell or a tissue." [GOC:ai] is_a: GO:0046903 ! secretion [Term] id: GO:0046785 name: microtubule polymerization namespace: biological_process def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] synonym: "microtubule assembly" EXACT [] synonym: "microtubule formation" RELATED [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051258 ! protein polymerization is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005874 ! results in assembly of microtubule relationship: RO:0002224 GO:0007020 ! starts with microtubule nucleation relationship: RO:0002588 GO:0005874 ! results in assembly of microtubule [Term] id: GO:0046822 name: regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006913 ! regulates nucleocytoplasmic transport relationship: RO:0002211 GO:0006913 ! regulates nucleocytoplasmic transport [Term] id: GO:0046823 name: negative regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] synonym: "down regulation of nucleocytoplasmic transport" EXACT [] synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] synonym: "downregulation of nucleocytoplasmic transport" EXACT [] synonym: "inhibition of nucleocytoplasmic transport" NARROW [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006913 ! negatively regulates nucleocytoplasmic transport relationship: RO:0002212 GO:0006913 ! negatively regulates nucleocytoplasmic transport [Term] id: GO:0046824 name: positive regulation of nucleocytoplasmic transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] synonym: "activation of nucleocytoplasmic transport" NARROW [] synonym: "stimulation of nucleocytoplasmic transport" NARROW [] synonym: "up regulation of nucleocytoplasmic transport" EXACT [] synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] synonym: "upregulation of nucleocytoplasmic transport" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006913 ! positively regulates nucleocytoplasmic transport relationship: RO:0002213 GO:0006913 ! positively regulates nucleocytoplasmic transport [Term] id: GO:0046825 name: regulation of protein export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of protein export from cell nucleus" EXACT [] synonym: "regulation of protein export out of nucleus" EXACT [] synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of protein-nucleus export" EXACT [] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006611 ! regulates protein export from nucleus relationship: RO:0002211 GO:0006611 ! regulates protein export from nucleus [Term] id: GO:0046826 name: negative regulation of protein export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of protein export from nucleus" EXACT [] synonym: "down-regulation of protein export from nucleus" EXACT [] synonym: "downregulation of protein export from nucleus" EXACT [] synonym: "inhibition of protein export from nucleus" NARROW [] synonym: "negative regulation of protein export from cell nucleus" EXACT [] synonym: "negative regulation of protein export out of nucleus" EXACT [] synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of protein-nucleus export" EXACT [] is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0051457 ! maintenance of protein location in nucleus is_a: GO:0090317 ! negative regulation of intracellular protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006611 ! negatively regulates protein export from nucleus relationship: RO:0002212 GO:0006611 ! negatively regulates protein export from nucleus [Term] id: GO:0046827 name: positive regulation of protein export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of protein export from nucleus" NARROW [] synonym: "positive regulation of protein export from cell nucleus" EXACT [] synonym: "positive regulation of protein export out of nucleus" EXACT [] synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of protein-nucleus export" EXACT [] synonym: "stimulation of protein export from nucleus" NARROW [] synonym: "up regulation of protein export from nucleus" EXACT [] synonym: "up-regulation of protein export from nucleus" EXACT [] synonym: "upregulation of protein export from nucleus" EXACT [] is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0090316 ! positive regulation of intracellular protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006611 ! positively regulates protein export from nucleus relationship: RO:0002213 GO:0006611 ! positively regulates protein export from nucleus [Term] id: GO:0046828 name: regulation of RNA import into nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] synonym: "regulation of RNA import into cell nucleus" EXACT [] synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "regulation of RNA-nucleus import" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006404 ! regulates RNA import into nucleus relationship: RO:0002211 GO:0006404 ! regulates RNA import into nucleus [Term] id: GO:0046829 name: negative regulation of RNA import into nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "down regulation of RNA import into nucleus" EXACT [] synonym: "down-regulation of RNA import into nucleus" EXACT [] synonym: "downregulation of RNA import into nucleus" EXACT [] synonym: "inhibition of RNA import into nucleus" NARROW [] synonym: "negative regulation of RNA import into cell nucleus" EXACT [] synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "negative regulation of RNA-nucleus import" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006404 ! negatively regulates RNA import into nucleus relationship: RO:0002212 GO:0006404 ! negatively regulates RNA import into nucleus [Term] id: GO:0046830 name: positive regulation of RNA import into nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] synonym: "activation of RNA import into nucleus" NARROW [] synonym: "positive regulation of RNA import into cell nucleus" EXACT [] synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] synonym: "positive regulation of RNA-nucleus import" EXACT [] synonym: "stimulation of RNA import into nucleus" NARROW [] synonym: "up regulation of RNA import into nucleus" EXACT [] synonym: "up-regulation of RNA import into nucleus" EXACT [] synonym: "upregulation of RNA import into nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046828 ! regulation of RNA import into nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006404 ! positively regulates RNA import into nucleus relationship: RO:0002213 GO:0006404 ! positively regulates RNA import into nucleus [Term] id: GO:0046831 name: regulation of RNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] synonym: "regulation of RNA export from cell nucleus" EXACT [] synonym: "regulation of RNA export out of nucleus" EXACT [] synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "regulation of RNA-nucleus export" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0046822 ! regulation of nucleocytoplasmic transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006405 ! regulates RNA export from nucleus relationship: RO:0002211 GO:0006405 ! regulates RNA export from nucleus [Term] id: GO:0046832 name: negative regulation of RNA export from nucleus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "down regulation of RNA export from nucleus" EXACT [] synonym: "down-regulation of RNA export from nucleus" EXACT [] synonym: "downregulation of RNA export from nucleus" EXACT [] synonym: "inhibition of RNA export from nucleus" NARROW [] synonym: "negative regulation of RNA export from cell nucleus" EXACT [] synonym: "negative regulation of RNA export out of nucleus" EXACT [] synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "negative regulation of RNA-nucleus export" EXACT [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006405 ! negatively regulates RNA export from nucleus relationship: RO:0002212 GO:0006405 ! negatively regulates RNA export from nucleus [Term] id: GO:0046833 name: positive regulation of RNA export from nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] synonym: "activation of RNA export from nucleus" NARROW [] synonym: "positive regulation of RNA export from cell nucleus" EXACT [] synonym: "positive regulation of RNA export out of nucleus" EXACT [] synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] synonym: "positive regulation of RNA-nucleus export" EXACT [] synonym: "stimulation of RNA export from nucleus" NARROW [] synonym: "up regulation of RNA export from nucleus" EXACT [] synonym: "up-regulation of RNA export from nucleus" EXACT [] synonym: "upregulation of RNA export from nucleus" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport is_a: GO:0046831 ! regulation of RNA export from nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006405 ! positively regulates RNA export from nucleus relationship: RO:0002213 GO:0006405 ! positively regulates RNA export from nucleus [Term] id: GO:0046849 name: bone remodeling namespace: biological_process def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators] synonym: "bone remodelling" EXACT [] xref: Wikipedia:Bone_remodeling is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0046850 name: regulation of bone remodeling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai] synonym: "regulation of bone remodelling" EXACT [] is_a: GO:0034103 ! regulation of tissue remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046849 ! regulates bone remodeling relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002211 GO:0046849 ! regulates bone remodeling [Term] id: GO:0046851 name: negative regulation of bone remodeling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "down regulation of bone remodeling" EXACT [] synonym: "down-regulation of bone remodeling" EXACT [] synonym: "downregulation of bone remodeling" EXACT [] synonym: "inhibition of bone remodeling" NARROW [] synonym: "negative regulation of bone remodelling" EXACT [] is_a: GO:0034104 ! negative regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046849 ! negatively regulates bone remodeling relationship: RO:0002212 GO:0046849 ! negatively regulates bone remodeling [Term] id: GO:0046852 name: positive regulation of bone remodeling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai] synonym: "activation of bone remodeling" NARROW [] synonym: "positive regulation of bone remodelling" EXACT [] synonym: "stimulation of bone remodeling" NARROW [] synonym: "up regulation of bone remodeling" EXACT [] synonym: "up-regulation of bone remodeling" EXACT [] synonym: "upregulation of bone remodeling" EXACT [] is_a: GO:0034105 ! positive regulation of tissue remodeling is_a: GO:0046850 ! regulation of bone remodeling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046849 ! positively regulates bone remodeling relationship: RO:0002213 GO:0046849 ! positively regulates bone remodeling [Term] id: GO:0046879 name: hormone secretion namespace: biological_process def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732] is_a: GO:0009914 ! hormone transport is_a: GO:0023061 ! signal release [Term] id: GO:0046883 name: regulation of hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0023051 ! regulation of signaling is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046879 ! regulates hormone secretion relationship: RO:0002211 GO:0046879 ! regulates hormone secretion [Term] id: GO:0046885 name: regulation of hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "regulation of hormone anabolism" EXACT [] synonym: "regulation of hormone biosynthesis" EXACT [] synonym: "regulation of hormone formation" EXACT [] synonym: "regulation of hormone synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042446 ! regulates hormone biosynthetic process relationship: RO:0002211 GO:0042446 ! regulates hormone biosynthetic process [Term] id: GO:0046886 name: positive regulation of hormone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "activation of hormone biosynthetic process" NARROW [] synonym: "positive regulation of hormone anabolism" EXACT [] synonym: "positive regulation of hormone biosynthesis" EXACT [] synonym: "positive regulation of hormone formation" EXACT [] synonym: "positive regulation of hormone synthesis" EXACT [] synonym: "stimulation of hormone biosynthetic process" NARROW [] synonym: "up regulation of hormone biosynthetic process" EXACT [] synonym: "up-regulation of hormone biosynthetic process" EXACT [] synonym: "upregulation of hormone biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042446 ! positively regulates hormone biosynthetic process relationship: RO:0002213 GO:0042446 ! positively regulates hormone biosynthetic process [Term] id: GO:0046887 name: positive regulation of hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "activation of hormone secretion" NARROW [] synonym: "stimulation of hormone secretion" NARROW [] synonym: "up regulation of hormone secretion" EXACT [] synonym: "up-regulation of hormone secretion" EXACT [] synonym: "upregulation of hormone secretion" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046879 ! positively regulates hormone secretion relationship: RO:0002213 GO:0046879 ! positively regulates hormone secretion [Term] id: GO:0046888 name: negative regulation of hormone secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] synonym: "down regulation of hormone secretion" EXACT [] synonym: "down-regulation of hormone secretion" EXACT [] synonym: "downregulation of hormone secretion" EXACT [] synonym: "inhibition of hormone secretion" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046879 ! negatively regulates hormone secretion relationship: RO:0002212 GO:0046879 ! negatively regulates hormone secretion [Term] id: GO:0046889 name: positive regulation of lipid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "activation of lipid biosynthetic process" NARROW [] synonym: "positive regulation of lipid anabolism" EXACT [] synonym: "positive regulation of lipid biosynthesis" EXACT [] synonym: "positive regulation of lipid formation" EXACT [] synonym: "positive regulation of lipid synthesis" EXACT [] synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] synonym: "stimulation of lipid biosynthetic process" NARROW [] synonym: "up regulation of lipid biosynthetic process" EXACT [] synonym: "up-regulation of lipid biosynthetic process" EXACT [] synonym: "upregulation of lipid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process relationship: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process [Term] id: GO:0046890 name: regulation of lipid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "regulation of lipid anabolism" EXACT [] synonym: "regulation of lipid biosynthesis" EXACT [] synonym: "regulation of lipid formation" EXACT [] synonym: "regulation of lipid synthesis" EXACT [] synonym: "regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process relationship: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0046907 name: intracellular transport namespace: biological_process alt_id: GO:1902582 def: "The directed movement of substances within a cell." [GOC:ai] subset: gocheck_do_not_annotate synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intracellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0051641 ! cellular localization is_a: GO:0051649 ! establishment of localization in cell intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:0046928 name: regulation of neurotransmitter secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion relationship: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion [Term] id: GO:0046929 name: negative regulation of neurotransmitter secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] synonym: "conotoxin activity" NARROW [] synonym: "down regulation of neurotransmitter secretion" EXACT [] synonym: "down-regulation of neurotransmitter secretion" EXACT [] synonym: "downregulation of neurotransmitter secretion" EXACT [] synonym: "inhibition of neurotransmitter secretion" NARROW [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion relationship: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0046943 name: carboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion relationship: BFO:0000050 GO:1905039 ! part of carboxylic acid transmembrane transport relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion [Term] id: GO:0047496 name: vesicle transport along microtubule namespace: biological_process def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0047497 name: mitochondrion transport along microtubule namespace: biological_process def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] synonym: "mitochondrial migration along microtubule" EXACT [] synonym: "mitochondrial transport along microtubule" EXACT [] is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated is_a: GO:0072384 ! organelle transport along microtubule intersection_of: GO:0006810 ! transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0048020 name: CCR chemokine receptor binding namespace: molecular_function def: "Binding to a CCR chemokine receptor." [GOC:ai] synonym: "beta chemokine receptor binding" EXACT [] synonym: "beta chemokine receptor ligand" NARROW [] synonym: "CCR chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0048029 name: monosaccharide binding namespace: molecular_function def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] is_a: GO:0030246 ! carbohydrate binding is_a: GO:0036094 ! small molecule binding [Term] id: GO:0048048 name: embryonic eye morphogenesis namespace: biological_process def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis is_a: GO:0048592 ! eye morphogenesis [Term] id: GO:0048066 name: developmental pigmentation namespace: biological_process def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] synonym: "pigmentation during development" RELATED [] is_a: GO:0043473 ! pigmentation [Term] id: GO:0048070 name: regulation of developmental pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb] is_a: GO:0120305 ! regulation of pigmentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048066 ! regulates developmental pigmentation relationship: RO:0002211 GO:0048066 ! regulates developmental pigmentation [Term] id: GO:0048086 name: negative regulation of developmental pigmentation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of pigmentation" NARROW [] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation relationship: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation [Term] id: GO:0048087 name: positive regulation of developmental pigmentation namespace: biological_process def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph] synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048070 ! regulation of developmental pigmentation is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation relationship: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation [Term] id: GO:0048102 name: autophagic cell death namespace: biological_process def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517] comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. synonym: "autophagic death" BROAD [] synonym: "autosis" RELATED [PMID:25236395] synonym: "programmed cell death by autophagy" BROAD [GOC:pr] synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm] synonym: "type II programmed cell death" RELATED [GOC:sl] is_a: GO:0012501 ! programmed cell death intersection_of: GO:0012501 ! programmed cell death intersection_of: BFO:0000051 GO:0016236 ! has part macroautophagy relationship: BFO:0000051 GO:0016236 ! has part macroautophagy [Term] id: GO:0048103 name: somatic stem cell division namespace: biological_process def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] synonym: "somatic stem cell renewal" EXACT [] is_a: GO:0017145 ! stem cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000723 ! has primary input somatic stem cell relationship: RO:0004009 CL:0000723 ! has primary input somatic stem cell [Term] id: GO:0048132 name: female germ-line stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] synonym: "female germ-line stem cell renewal" EXACT [] is_a: GO:0098728 ! germline stem cell asymmetric division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000022 ! has primary input female germ line stem cell relationship: BFO:0000050 GO:0048477 ! part of oogenesis relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0004009 CL:0000022 ! has primary input female germ line stem cell [Term] id: GO:0048143 name: astrocyte activation namespace: biological_process def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813] is_a: GO:0061900 ! glial cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000127 ! has primary input astrocyte relationship: BFO:0000050 GO:0014002 ! part of astrocyte development relationship: RO:0004009 CL:0000127 ! has primary input astrocyte [Term] id: GO:0048144 name: fibroblast proliferation namespace: biological_process def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000057 ! acts on population of fibroblast relationship: RO:0012003 CL:0000057 ! acts on population of fibroblast [Term] id: GO:0048145 name: regulation of fibroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048144 ! regulates fibroblast proliferation relationship: RO:0002211 GO:0048144 ! regulates fibroblast proliferation [Term] id: GO:0048146 name: positive regulation of fibroblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "activation of fibroblast proliferation" NARROW [] synonym: "stimulation of fibroblast proliferation" NARROW [] synonym: "up regulation of fibroblast proliferation" EXACT [] synonym: "up-regulation of fibroblast proliferation" EXACT [] synonym: "upregulation of fibroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation relationship: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation [Term] id: GO:0048147 name: negative regulation of fibroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] synonym: "down regulation of fibroblast proliferation" EXACT [] synonym: "down-regulation of fibroblast proliferation" EXACT [] synonym: "downregulation of fibroblast proliferation" EXACT [] synonym: "inhibition of fibroblast proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048145 ! regulation of fibroblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation relationship: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation [Term] id: GO:0048193 name: Golgi vesicle transport namespace: biological_process def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] subset: goslim_yeast synonym: "Golgi-derived vesicle transport" RELATED [] is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle relationship: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle [Term] id: GO:0048194 name: Golgi vesicle budding namespace: biological_process def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle budding" NARROW [] synonym: "Golgi-derived vesicle budding" EXACT [] is_a: GO:0006900 ! vesicle budding from membrane intersection_of: GO:0006900 ! vesicle budding from membrane intersection_of: BFO:0000066 GO:0000139 ! occurs in Golgi membrane intersection_of: RO:0004008 GO:0005798 ! has primary output Golgi-associated vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: BFO:0000066 GO:0000139 ! occurs in Golgi membrane relationship: RO:0004008 GO:0005798 ! has primary output Golgi-associated vesicle [Term] id: GO:0048199 name: vesicle targeting, to, from or within Golgi namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "dictyosome vesicle targeting" NARROW [] synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting intersection_of: GO:0006903 ! vesicle targeting intersection_of: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus intersection_of: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus relationship: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle [Term] id: GO:0048209 name: regulation of vesicle targeting, to, from or within Golgi namespace: biological_process def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] synonym: "regulation of Golgi vesicle targeting" EXACT [] is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi relationship: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi [Term] id: GO:0048243 name: norepinephrine secretion namespace: biological_process def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid] synonym: "noradrenaline secretion" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0023061 ! signal release is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0048246 name: macrophage chemotaxis namespace: biological_process def: "The movement of a macrophage in response to an external stimulus." [GOC:jid] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:1905517 ! macrophage migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000235 ! results in movement of macrophage [Term] id: GO:0048247 name: lymphocyte chemotaxis namespace: biological_process def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0072676 ! lymphocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000542 ! results in movement of lymphocyte [Term] id: GO:0048251 name: elastic fiber assembly namespace: biological_process def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674] synonym: "elastic fibre assembly" EXACT [] synonym: "elastin fiber assembly" EXACT [GOC:BHF] synonym: "elastin fibre assembly" EXACT [GOC:BHF] is_a: GO:0085029 ! extracellular matrix assembly is_a: GO:0097435 ! supramolecular fiber organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0071953 ! results in assembly of elastic fiber relationship: RO:0002588 GO:0071953 ! results in assembly of elastic fiber [Term] id: GO:0048280 name: vesicle fusion with Golgi apparatus namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid] is_a: GO:0006906 ! vesicle fusion is_a: GO:0007030 ! Golgi organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0043226 ! results in fusion of organelle relationship: RO:0012008 GO:0043226 ! results in fusion of organelle [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization intersection_of: GO:0009987 ! cellular process intersection_of: GOREL:0002004 GO:0043226 ! results in fission of organelle relationship: GOREL:0002004 GO:0043226 ! results in fission of organelle [Term] id: GO:0048288 name: nuclear membrane fusion involved in karyogamy namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0000740 ! nuclear membrane fusion intersection_of: GO:0000740 ! nuclear membrane fusion intersection_of: BFO:0000050 GO:0000741 ! part of karyogamy relationship: BFO:0000050 GO:0000741 ! part of karyogamy [Term] id: GO:0048308 name: organelle inheritance namespace: biological_process def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization [Term] id: GO:0048311 name: mitochondrion distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] synonym: "distribution of mitochondria" EXACT [] synonym: "mitochondrial distribution" EXACT [] synonym: "positioning of mitochondria" RELATED [] is_a: GO:0051646 ! mitochondrion localization [Term] id: GO:0048313 name: Golgi inheritance namespace: biological_process def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069] synonym: "Golgi apparatus inheritance" EXACT [] synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi partitioning" EXACT [] xref: Reactome:R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization" is_a: GO:0007030 ! Golgi organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance intersection_of: GOREL:0002003 GO:0005794 ! results in distribution of Golgi apparatus relationship: GOREL:0002003 GO:0005794 ! results in distribution of Golgi apparatus [Term] id: GO:0048318 name: axial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] is_a: GO:0007498 ! mesoderm development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm relationship: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm [Term] id: GO:0048319 name: axial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm relationship: BFO:0000050 GO:0048318 ! part of axial mesoderm development relationship: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm [Term] id: GO:0048320 name: axial mesoderm formation namespace: biological_process def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9796292 "Formation of axial mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003068 ! results in formation of axial mesoderm relationship: BFO:0000050 GO:0048319 ! part of axial mesoderm morphogenesis relationship: RO:0002297 UBERON:0003068 ! results in formation of axial mesoderm [Term] id: GO:0048332 name: mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm relationship: BFO:0000050 GO:0007498 ! part of mesoderm development relationship: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm [Term] id: GO:0048333 name: mesodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] synonym: "mesoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell relationship: BFO:0000050 GO:0001707 ! part of mesoderm formation relationship: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell [Term] id: GO:0048339 name: paraxial mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm relationship: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm [Term] id: GO:0048340 name: paraxial mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm relationship: BFO:0000050 GO:0048339 ! part of paraxial mesoderm development relationship: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm [Term] id: GO:0048341 name: paraxial mesoderm formation namespace: biological_process def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9793380 "Formation of paraxial mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003077 ! results in formation of paraxial mesoderm relationship: BFO:0000050 GO:0048340 ! part of paraxial mesoderm morphogenesis relationship: RO:0002297 UBERON:0003077 ! results in formation of paraxial mesoderm [Term] id: GO:0048368 name: lateral mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] synonym: "lateral plate mesoderm development" EXACT [] is_a: GO:0007498 ! mesoderm development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm relationship: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm [Term] id: GO:0048369 name: lateral mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators] synonym: "lateral plate mesoderm morphogenesis" EXACT [] is_a: GO:0048332 ! mesoderm morphogenesis is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm relationship: BFO:0000050 GO:0048368 ! part of lateral mesoderm development relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm [Term] id: GO:0048370 name: lateral mesoderm formation namespace: biological_process def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid] synonym: "lateral plate mesoderm biosynthesis" EXACT [] synonym: "lateral plate mesoderm formation" EXACT [] xref: Reactome:R-HSA-9758920 "Formation of lateral plate mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm relationship: BFO:0000050 GO:0048369 ! part of lateral mesoderm morphogenesis relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm [Term] id: GO:0048389 name: intermediate mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] is_a: GO:0007498 ! mesoderm development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm relationship: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm [Term] id: GO:0048390 name: intermediate mesoderm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators] is_a: GO:0048332 ! mesoderm morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm relationship: BFO:0000050 GO:0048389 ! part of intermediate mesoderm development relationship: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm [Term] id: GO:0048391 name: intermediate mesoderm formation namespace: biological_process def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] xref: Reactome:R-HSA-9761174 "Formation of intermediate mesoderm" is_a: GO:0001707 ! mesoderm formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003064 ! results in formation of intermediate mesoderm relationship: BFO:0000050 GO:0048390 ! part of intermediate mesoderm morphogenesis relationship: RO:0002297 UBERON:0003064 ! results in formation of intermediate mesoderm [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators] subset: goslim_candida synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process intersection_of: GO:0008150 ! biological_process intersection_of: RO:0002296 CL:0000000 ! results in development of cell relationship: BFO:0000050 GO:0030154 ! part of cell differentiation relationship: RO:0002296 CL:0000000 ! results in development of cell [Term] id: GO:0048469 name: cell maturation namespace: biological_process def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000000 ! results in maturation of cell relationship: BFO:0000050 GO:0048468 ! part of cell development relationship: RO:0002299 CL:0000000 ! results in maturation of cell [Term] id: GO:0048477 name: oogenesis namespace: biological_process def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] xref: Wikipedia:Oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000025 ! results in development of egg cell relationship: RO:0002296 CL:0000025 ! results in development of egg cell [Term] id: GO:0048483 name: autonomic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system [Term] id: GO:0048485 name: sympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system [Term] id: GO:0048486 name: parasympathetic nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000011 ! results in development of parasympathetic nervous system relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002296 UBERON:0000011 ! results in development of parasympathetic nervous system [Term] id: GO:0048505 name: regulation of timing of cell differentiation namespace: biological_process def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] synonym: "timing of cell differentiation" RELATED [] is_a: GO:0040034 ! regulation of development, heterochronic is_a: GO:0045595 ! regulation of cell differentiation [Term] id: GO:0048513 name: animal organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0048514 name: blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008150 ! positively regulates biological_process relationship: RO:0002213 GO:0008150 ! positively regulates biological_process [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008150 ! negatively regulates biological_process relationship: RO:0002212 GO:0008150 ! negatively regulates biological_process [Term] id: GO:0048520 name: positive regulation of behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "activation of behavior" NARROW [] synonym: "stimulation of behavior" NARROW [] synonym: "up regulation of behavior" EXACT [] synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007610 ! positively regulates behavior relationship: RO:0002213 GO:0007610 ! positively regulates behavior [Term] id: GO:0048521 name: negative regulation of behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] synonym: "down regulation of behavior" EXACT [] synonym: "down-regulation of behavior" EXACT [] synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0050795 ! regulation of behavior is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007610 ! negatively regulates behavior relationship: RO:0002212 GO:0007610 ! negatively regulates behavior [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009987 ! positively regulates cellular process relationship: RO:0002213 GO:0009987 ! positively regulates cellular process [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gocheck_do_not_annotate synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009987 ! negatively regulates cellular process relationship: RO:0002212 GO:0009987 ! negatively regulates cellular process [Term] id: GO:0048534 name: hematopoietic or lymphoid organ development namespace: biological_process def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] synonym: "haematopoietic or lymphoid organ development" EXACT [] synonym: "haemopoietic or lymphoid organ development" EXACT [] synonym: "hemopoietic or lymphoid organ development" EXACT [] is_a: GO:0048513 ! animal organ development relationship: BFO:0000050 GO:0002520 ! part of immune system development [Term] id: GO:0048539 name: bone marrow development namespace: biological_process def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149] is_a: GO:0009888 ! tissue development is_a: GO:0048534 ! hematopoietic or lymphoid organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002371 ! results in development of bone marrow relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002296 UBERON:0002371 ! results in development of bone marrow [Term] id: GO:0048545 name: response to steroid hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] synonym: "response to steroid hormone stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:26764 ! has primary input relationship: RO:0004009 CHEBI:26764 ! has primary input [Term] id: GO:0048546 name: digestive tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] synonym: "alimentary canal morphogenesis" EXACT [] synonym: "digestive tube morphogenesis" EXACT [] synonym: "gastrointestinal tract morphogenesis" EXACT [] synonym: "gut morphogenesis" BROAD [GOC:dph] synonym: "intestinal morphogenesis" NARROW [] is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract [Term] id: GO:0048562 name: embryonic organ morphogenesis namespace: biological_process def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: BFO:0000050 GO:0048568 ! part of embryonic organ development [Term] id: GO:0048565 name: digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] synonym: "gut development" BROAD [GOC:dph] synonym: "intestinal development" NARROW [] synonym: "intestine development" NARROW [] is_a: GO:0035295 ! tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001555 ! results in development of digestive tract relationship: BFO:0000050 GO:0055123 ! part of digestive system development relationship: RO:0002296 UBERON:0001555 ! results in development of digestive tract [Term] id: GO:0048568 name: embryonic organ development namespace: biological_process def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] synonym: "embryonic organogenesis" EXACT [] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: BFO:0000050 GO:0009790 ! part of embryo development intersection_of: RO:0002296 UBERON:0000062 ! results in development of organ relationship: BFO:0000050 GO:0009790 ! part of embryo development relationship: RO:0002296 UBERON:0000062 ! results in development of organ [Term] id: GO:0048570 name: notochord morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] is_a: GO:0048562 ! embryonic organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord relationship: BFO:0000050 GO:0030903 ! part of notochord development relationship: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord [Term] id: GO:0048580 name: regulation of post-embryonic development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009791 ! regulates post-embryonic development relationship: RO:0002211 GO:0009791 ! regulates post-embryonic development [Term] id: GO:0048581 name: negative regulation of post-embryonic development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "down regulation of post-embryonic development" EXACT [] synonym: "down-regulation of post-embryonic development" EXACT [] synonym: "downregulation of post-embryonic development" EXACT [] synonym: "inhibition of post-embryonic development" NARROW [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development relationship: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development [Term] id: GO:0048582 name: positive regulation of post-embryonic development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] synonym: "activation of post-embryonic development" NARROW [] synonym: "stimulation of post-embryonic development" NARROW [] synonym: "up regulation of post-embryonic development" EXACT [] synonym: "up-regulation of post-embryonic development" EXACT [] synonym: "upregulation of post-embryonic development" EXACT [] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009791 ! positively regulates post-embryonic development relationship: RO:0002213 GO:0009791 ! positively regulates post-embryonic development [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050896 ! regulates response to stimulus relationship: RO:0002211 GO:0050896 ! regulates response to stimulus [Term] id: GO:0048584 name: positive regulation of response to stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "activation of response to stimulus" NARROW [] synonym: "stimulation of response to stimulus" NARROW [] synonym: "up regulation of response to stimulus" EXACT [] synonym: "up-regulation of response to stimulus" EXACT [] synonym: "upregulation of response to stimulus" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050896 ! positively regulates response to stimulus relationship: RO:0002213 GO:0050896 ! positively regulates response to stimulus [Term] id: GO:0048585 name: negative regulation of response to stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "down regulation of response to stimulus" EXACT [] synonym: "down-regulation of response to stimulus" EXACT [] synonym: "downregulation of response to stimulus" EXACT [] synonym: "inhibition of response to stimulus" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050896 ! negatively regulates response to stimulus relationship: RO:0002212 GO:0050896 ! negatively regulates response to stimulus [Term] id: GO:0048588 name: developmental cell growth namespace: biological_process def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] subset: gocheck_do_not_annotate synonym: "developmental growth of a unicellular organism" EXACT [] is_a: GO:0016049 ! cell growth is_a: GO:0048589 ! developmental growth relationship: BFO:0000050 GO:0048468 ! part of cell development [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0040007 ! growth intersection_of: GO:0040007 ! growth intersection_of: BFO:0000050 GO:0032502 ! part of developmental process relationship: BFO:0000050 GO:0032502 ! part of developmental process [Term] id: GO:0048592 name: eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye relationship: BFO:0000050 GO:0001654 ! part of eye development relationship: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye [Term] id: GO:0048593 name: camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu] synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye [Term] id: GO:0048596 name: embryonic camera-type eye morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic eye morphogenesis" BROAD [] is_a: GO:0048048 ! embryonic eye morphogenesis relationship: BFO:0000050 GO:0031076 ! part of embryonic camera-type eye development relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis [Term] id: GO:0048598 name: embryonic morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: BFO:0000050 GO:0009790 ! part of embryo development [Term] id: GO:0048599 name: oocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] is_a: GO:0007281 ! germ cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000023 ! results in development of oocyte relationship: BFO:0000050 GO:0009994 ! part of oocyte differentiation relationship: RO:0002296 CL:0000023 ! results in development of oocyte [Term] id: GO:0048601 name: oocyte morphogenesis namespace: biological_process def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] synonym: "oocyte morphogenesis during differentiation" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte relationship: BFO:0000050 GO:0048599 ! part of oocyte development relationship: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: BFO:0000050 GO:0061458 ! part of reproductive system development [Term] id: GO:0048609 name: multicellular organismal reproductive process namespace: biological_process def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] subset: gocheck_do_not_annotate subset: goslim_drosophila synonym: "organismal reproductive process" BROAD [] synonym: "reproductive process in a multicellular organism" EXACT [] xref: Reactome:R-HSA-1474165 "Reproduction" is_a: GO:0022414 ! reproductive process [Term] id: GO:0048627 name: myoblast development namespace: biological_process def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000056 ! results in development of myoblast relationship: BFO:0000050 GO:0045445 ! part of myoblast differentiation relationship: RO:0002296 CL:0000056 ! results in development of myoblast [Term] id: GO:0048628 name: myoblast maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000056 ! results in maturation of myoblast relationship: BFO:0000050 GO:0048627 ! part of myoblast development relationship: RO:0002299 CL:0000056 ! results in maturation of myoblast [Term] id: GO:0048630 name: skeletal muscle tissue growth namespace: biological_process def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue [Term] id: GO:0048631 name: regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth relationship: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth [Term] id: GO:0048632 name: negative regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "down regulation of skeletal muscle growth" EXACT [] synonym: "down-regulation of skeletal muscle growth" EXACT [] synonym: "downregulation of skeletal muscle growth" EXACT [] synonym: "inhibition of skeletal muscle growth" NARROW [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048640 ! negative regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth relationship: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth [Term] id: GO:0048633 name: positive regulation of skeletal muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] synonym: "activation of skeletal muscle growth" NARROW [] synonym: "stimulation of skeletal muscle growth" NARROW [] synonym: "up regulation of skeletal muscle growth" EXACT [] synonym: "up-regulation of skeletal muscle growth" EXACT [] synonym: "upregulation of skeletal muscle growth" EXACT [] is_a: GO:0048631 ! regulation of skeletal muscle tissue growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth relationship: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth [Term] id: GO:0048634 name: regulation of muscle organ development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007517 ! regulates muscle organ development relationship: RO:0002211 GO:0007517 ! regulates muscle organ development [Term] id: GO:0048635 name: negative regulation of muscle organ development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] synonym: "down regulation of muscle development" EXACT [] synonym: "down-regulation of muscle development" EXACT [] synonym: "downregulation of muscle development" EXACT [] synonym: "inhibition of muscle development" NARROW [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007517 ! negatively regulates muscle organ development relationship: RO:0002212 GO:0007517 ! negatively regulates muscle organ development [Term] id: GO:0048636 name: positive regulation of muscle organ development namespace: biological_process def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] synonym: "activation of muscle development" NARROW [] synonym: "stimulation of muscle development" NARROW [] synonym: "up regulation of muscle development" EXACT [] synonym: "up-regulation of muscle development" EXACT [] synonym: "upregulation of muscle development" EXACT [] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007517 ! positively regulates muscle organ development relationship: RO:0002213 GO:0007517 ! positively regulates muscle organ development [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048589 ! regulates developmental growth relationship: RO:0002211 GO:0048589 ! regulates developmental growth [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048589 ! positively regulates developmental growth relationship: RO:0002213 GO:0048589 ! positively regulates developmental growth [Term] id: GO:0048640 name: negative regulation of developmental growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] synonym: "down regulation of developmental growth" EXACT [] synonym: "down-regulation of developmental growth" EXACT [] synonym: "downregulation of developmental growth" EXACT [] synonym: "inhibition of developmental growth" NARROW [] is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048589 ! negatively regulates developmental growth relationship: RO:0002212 GO:0048589 ! negatively regulates developmental growth [Term] id: GO:0048641 name: regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development relationship: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development [Term] id: GO:0048642 name: negative regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] synonym: "down regulation of skeletal muscle development" EXACT [] synonym: "down-regulation of skeletal muscle development" EXACT [] synonym: "downregulation of skeletal muscle development" EXACT [] synonym: "inhibition of skeletal muscle development" NARROW [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development relationship: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development [Term] id: GO:0048643 name: positive regulation of skeletal muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators] synonym: "activation of skeletal muscle development" NARROW [] synonym: "stimulation of skeletal muscle development" NARROW [] synonym: "up regulation of skeletal muscle development" EXACT [] synonym: "up-regulation of skeletal muscle development" EXACT [] synonym: "upregulation of skeletal muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0048641 ! regulation of skeletal muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development relationship: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development [Term] id: GO:0048644 name: muscle organ morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ relationship: BFO:0000050 GO:0007517 ! part of muscle organ development relationship: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ [Term] id: GO:0048645 name: animal organ formation namespace: biological_process def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] synonym: "animal organ primordium initiation" NARROW [] synonym: "initiation of an animal organ primordium" NARROW [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003103 ! results in formation of compound organ relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis relationship: RO:0002297 UBERON:0003103 ! results in formation of compound organ [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis [Term] id: GO:0048659 name: smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] synonym: "SMC proliferation" EXACT [] is_a: GO:0033002 ! muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell relationship: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell [Term] id: GO:0048660 name: regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "regulation of SMC proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation relationship: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation [Term] id: GO:0048661 name: positive regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "activation of smooth muscle cell proliferation" NARROW [] synonym: "positive regulation of SMC proliferation" EXACT [] synonym: "stimulation of smooth muscle cell proliferation" NARROW [] synonym: "up regulation of smooth muscle cell proliferation" EXACT [] synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] synonym: "upregulation of smooth muscle cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation relationship: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation [Term] id: GO:0048662 name: negative regulation of smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] synonym: "down regulation of smooth muscle cell proliferation" EXACT [] synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] synonym: "downregulation of smooth muscle cell proliferation" EXACT [] synonym: "inhibition of smooth muscle cell proliferation" NARROW [] synonym: "negative regulation of SMC proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation relationship: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation [Term] id: GO:0048666 name: neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000540 ! results in development of neuron relationship: BFO:0000050 GO:0030182 ! part of neuron differentiation relationship: RO:0002296 CL:0000540 ! results in development of neuron [Term] id: GO:0048667 name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: BFO:0000050 GO:0030182 ! part of neuron differentiation relationship: BFO:0000050 GO:0048666 ! part of neuron development [Term] id: GO:0048699 name: generation of neurons namespace: biological_process def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] synonym: "neuron generation" EXACT [] is_a: GO:0022008 ! neurogenesis [Term] id: GO:0048705 name: skeletal system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system relationship: BFO:0000050 GO:0001501 ! part of skeletal system development relationship: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system [Term] id: GO:0048708 name: astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000127 ! results in acquisition of features of astrocyte relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:0000127 ! results in acquisition of features of astrocyte [Term] id: GO:0048709 name: oligodendrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000128 ! results in acquisition of features of oligodendrocyte relationship: BFO:0000050 GO:0007417 ! part of central nervous system development relationship: RO:0002315 CL:0000128 ! results in acquisition of features of oligodendrocyte [Term] id: GO:0048710 name: regulation of astrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048708 ! regulates astrocyte differentiation relationship: RO:0002211 GO:0048708 ! regulates astrocyte differentiation [Term] id: GO:0048711 name: positive regulation of astrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of astrocyte differentiation" NARROW [] synonym: "stimulation of astrocyte differentiation" NARROW [] synonym: "up regulation of astrocyte differentiation" EXACT [] synonym: "up-regulation of astrocyte differentiation" EXACT [] synonym: "upregulation of astrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048708 ! positively regulates astrocyte differentiation relationship: RO:0002213 GO:0048708 ! positively regulates astrocyte differentiation [Term] id: GO:0048712 name: negative regulation of astrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of astrocyte differentiation" EXACT [] synonym: "down-regulation of astrocyte differentiation" EXACT [] synonym: "downregulation of astrocyte differentiation" EXACT [] synonym: "inhibition of astrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048710 ! regulation of astrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048708 ! negatively regulates astrocyte differentiation relationship: RO:0002212 GO:0048708 ! negatively regulates astrocyte differentiation [Term] id: GO:0048713 name: regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] is_a: GO:0045685 ! regulation of glial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048709 ! regulates oligodendrocyte differentiation relationship: RO:0002211 GO:0048709 ! regulates oligodendrocyte differentiation [Term] id: GO:0048714 name: positive regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "activation of oligodendrocyte differentiation" NARROW [] synonym: "stimulation of oligodendrocyte differentiation" NARROW [] synonym: "up regulation of oligodendrocyte differentiation" EXACT [] synonym: "up-regulation of oligodendrocyte differentiation" EXACT [] synonym: "upregulation of oligodendrocyte differentiation" EXACT [] is_a: GO:0045687 ! positive regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048709 ! positively regulates oligodendrocyte differentiation relationship: RO:0002213 GO:0048709 ! positively regulates oligodendrocyte differentiation [Term] id: GO:0048715 name: negative regulation of oligodendrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] synonym: "down regulation of oligodendrocyte differentiation" EXACT [] synonym: "down-regulation of oligodendrocyte differentiation" EXACT [] synonym: "downregulation of oligodendrocyte differentiation" EXACT [] synonym: "inhibition of oligodendrocyte differentiation" NARROW [] is_a: GO:0045686 ! negative regulation of glial cell differentiation is_a: GO:0048713 ! regulation of oligodendrocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048709 ! negatively regulates oligodendrocyte differentiation relationship: RO:0002212 GO:0048709 ! negatively regulates oligodendrocyte differentiation [Term] id: GO:0048729 name: tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue relationship: BFO:0000050 GO:0009888 ! part of tissue development relationship: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue [Term] id: GO:0048730 name: epidermis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003] synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium relationship: BFO:0000050 GO:0008544 ! part of epidermis development relationship: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] subset: goslim_mouse is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000467 ! results in development of anatomical system relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: RO:0002296 UBERON:0000467 ! results in development of anatomical system [Term] id: GO:0048732 name: gland development namespace: biological_process def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002530 ! results in development of gland relationship: RO:0002296 UBERON:0002530 ! results in development of gland [Term] id: GO:0048736 name: appendage development namespace: biological_process def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000026 ! results in development of appendage relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development relationship: RO:0002296 UBERON:0000026 ! results in development of appendage [Term] id: GO:0048738 name: cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] synonym: "heart muscle development" EXACT [] is_a: GO:0014706 ! striated muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue [Term] id: GO:0048741 name: skeletal muscle fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "skeletal muscle fibre development" EXACT [] synonym: "skeletal myofiber development" EXACT [] synonym: "skeletal myofibre development" EXACT [] is_a: GO:0014904 ! myotube cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development relationship: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber [Term] id: GO:0048742 name: regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm] synonym: "regulation of skeletal muscle fibre development" EXACT [] synonym: "regulation of skeletal myofiber development" EXACT [] synonym: "regulation of skeletal myofibre development" EXACT [] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development relationship: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development [Term] id: GO:0048743 name: positive regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "activation of skeletal muscle fiber development" NARROW [] synonym: "positive regulation of skeletal muscle fibre development" EXACT [] synonym: "positive regulation of skeletal myofiber development" EXACT [] synonym: "positive regulation of skeletal myofibre development" EXACT [] synonym: "stimulation of skeletal muscle fiber development" NARROW [] synonym: "up regulation of skeletal muscle fiber development" EXACT [] synonym: "up-regulation of skeletal muscle fiber development" EXACT [] synonym: "upregulation of skeletal muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development relationship: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development [Term] id: GO:0048744 name: negative regulation of skeletal muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] synonym: "down regulation of skeletal muscle fiber development" EXACT [] synonym: "down-regulation of skeletal muscle fiber development" EXACT [] synonym: "downregulation of skeletal muscle fiber development" EXACT [] synonym: "inhibition of skeletal muscle fiber development" NARROW [] synonym: "negative regulation of skeletal muscle fibre development" EXACT [] synonym: "negative regulation of skeletal myofiber development" EXACT [] synonym: "negative regulation of skeletal myofibre development" EXACT [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development relationship: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development [Term] id: GO:0048745 name: smooth muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] is_a: GO:0060537 ! muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue relationship: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue [Term] id: GO:0048749 name: compound eye development namespace: biological_process def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] synonym: "insect-type retina development" EXACT [PMID:11735386] is_a: GO:0001654 ! eye development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000018 ! results in development of compound eye relationship: RO:0002296 UBERON:0000018 ! results in development of compound eye [Term] id: GO:0048753 name: pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] subset: goslim_pir synonym: "pigment granule organisation" EXACT [] synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0048770 ! results in organization of pigment granule relationship: BFO:0000050 GO:0033059 ! part of cellular pigmentation relationship: RO:0002592 GO:0048770 ! results in organization of pigment granule [Term] id: GO:0048754 name: branching morphogenesis of an epithelial tube namespace: biological_process def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035239 ! tube morphogenesis is_a: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube relationship: BFO:0000050 GO:0060562 ! part of epithelial tube morphogenesis [Term] id: GO:0048755 name: branching morphogenesis of a nerve namespace: biological_process def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0001763 ! morphogenesis of a branching structure intersection_of: GO:0001763 ! morphogenesis of a branching structure intersection_of: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve [Term] id: GO:0048762 name: mesenchymal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell relationship: BFO:0000050 GO:0060485 ! part of mesenchyme development relationship: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell [Term] id: GO:0048770 name: pigment granule namespace: cellular_component def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0048771 name: tissue remodeling namespace: biological_process def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc] subset: goslim_pir synonym: "tissue remodelling" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0048799 name: animal organ maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000062 ! results in maturation of organ relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002299 UBERON:0000062 ! results in maturation of organ [Term] id: GO:0048806 name: genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] synonym: "genital development" EXACT [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development relationship: BFO:0000050 GO:0007548 ! part of sex differentiation [Term] id: GO:0048812 name: neuron projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection relationship: BFO:0000050 GO:0031175 ! part of neuron projection development relationship: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection [Term] id: GO:0048813 name: dendrite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a dendrite are generated and organized." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0048812 ! neuron projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0030425 ! results in morphogenesis of dendrite relationship: BFO:0000050 GO:0016358 ! part of dendrite development relationship: BFO:0000050 GO:0048667 ! part of cell morphogenesis involved in neuron differentiation relationship: RO:0002298 GO:0030425 ! results in morphogenesis of dendrite [Term] id: GO:0048814 name: regulation of dendrite morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0050773 ! regulation of dendrite development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048813 ! regulates dendrite morphogenesis relationship: RO:0002211 GO:0048813 ! regulates dendrite morphogenesis [Term] id: GO:0048821 name: erythrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol] synonym: "RBC development" EXACT [CL:0000232] synonym: "red blood cell development" EXACT [CL:0000232] is_a: GO:0061515 ! myeloid cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000232 ! results in development of erythrocyte relationship: BFO:0000050 GO:0030218 ! part of erythrocyte differentiation relationship: RO:0002296 CL:0000232 ! results in development of erythrocyte [Term] id: GO:0048823 name: nucleate erythrocyte development namespace: biological_process def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] synonym: "nucleate RBC development" EXACT [CL:0000232] synonym: "nucleate red blood cell development" EXACT [CL:0000232] is_a: GO:0048821 ! erythrocyte development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte relationship: BFO:0000050 GO:0043363 ! part of nucleate erythrocyte differentiation relationship: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte [Term] id: GO:0048844 name: artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] synonym: "arterial morphogenesis" EXACT [] synonym: "arteriogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery relationship: BFO:0000050 GO:0060840 ! part of artery development relationship: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery [Term] id: GO:0048845 name: venous blood vessel morphogenesis namespace: biological_process def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] synonym: "vein morphogenesis" BROAD [] synonym: "venous morphogenesis" EXACT [] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein relationship: BFO:0000050 GO:0060841 ! part of venous blood vessel development relationship: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein [Term] id: GO:0048847 name: adenohypophysis formation namespace: biological_process def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis biosynthesis" EXACT [] synonym: "adenophysis formation" EXACT [] synonym: "anterior pituitary biosynthesis" EXACT [] synonym: "anterior pituitary formation" EXACT [] synonym: "anterior pituitary gland biosynthesis" EXACT [] synonym: "anterior pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002196 ! results in formation of adenohypophysis relationship: BFO:0000050 GO:0048855 ! part of adenohypophysis morphogenesis relationship: RO:0002297 UBERON:0002196 ! results in formation of adenohypophysis [Term] id: GO:0048848 name: neurohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis morphogenesis" EXACT [] synonym: "posterior pituitary gland morphogenesis" EXACT [] synonym: "posterior pituitary morphogenesis" EXACT [] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002198 ! results in morphogenesis of neurohypophysis relationship: BFO:0000050 GO:0021985 ! part of neurohypophysis development relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis relationship: RO:0002298 UBERON:0002198 ! results in morphogenesis of neurohypophysis [Term] id: GO:0048849 name: neurohypophysis formation namespace: biological_process def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "neurophysis biosynthesis" EXACT [] synonym: "neurophysis formation" EXACT [] synonym: "posterior pituitary biosynthesis" EXACT [] synonym: "posterior pituitary formation" EXACT [] synonym: "posterior pituitary gland biosynthesis" EXACT [] synonym: "posterior pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002198 ! results in formation of neurohypophysis relationship: BFO:0000050 GO:0048848 ! part of neurohypophysis morphogenesis relationship: RO:0002297 UBERON:0002198 ! results in formation of neurohypophysis [Term] id: GO:0048850 name: hypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "pituitary gland morphogenesis" EXACT [] is_a: GO:0022612 ! gland morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000007 ! results in morphogenesis of pituitary gland relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development relationship: BFO:0000050 GO:0048852 ! part of diencephalon morphogenesis relationship: RO:0002298 UBERON:0000007 ! results in morphogenesis of pituitary gland [Term] id: GO:0048851 name: hypophysis formation namespace: biological_process def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] synonym: "hypophysis biosynthesis" EXACT [] synonym: "pituitary gland biosynthesis" EXACT [] synonym: "pituitary gland formation" EXACT [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000007 ! results in formation of pituitary gland relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis relationship: RO:0002297 UBERON:0000007 ! results in formation of pituitary gland [Term] id: GO:0048852 name: diencephalon morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001894 ! results in morphogenesis of diencephalon relationship: BFO:0000050 GO:0021536 ! part of diencephalon development relationship: BFO:0000050 GO:0048853 ! part of forebrain morphogenesis relationship: RO:0002298 UBERON:0001894 ! results in morphogenesis of diencephalon [Term] id: GO:0048853 name: forebrain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "prosencephalon morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001890 ! results in morphogenesis of forebrain relationship: BFO:0000050 GO:0030900 ! part of forebrain development relationship: BFO:0000050 GO:0048854 ! part of brain morphogenesis relationship: RO:0002298 UBERON:0001890 ! results in morphogenesis of forebrain [Term] id: GO:0048854 name: brain morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain relationship: BFO:0000050 GO:0007420 ! part of brain development relationship: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain [Term] id: GO:0048855 name: adenohypophysis morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] synonym: "adenophysis morphogenesis" EXACT [] synonym: "anterior pituitary gland morphogenesis" EXACT [] synonym: "anterior pituitary morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002196 ! results in morphogenesis of adenohypophysis relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis relationship: RO:0002298 UBERON:0002196 ! results in morphogenesis of adenohypophysis [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_plant_ribbon synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 UBERON:0000061 ! results in development of anatomical structure relationship: RO:0002296 UBERON:0000061 ! results in development of anatomical structure [Term] id: GO:0048857 name: neural nucleus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000125 ! results in development of neural nucleus relationship: RO:0002296 UBERON:0000125 ! results in development of neural nucleus [Term] id: GO:0048858 name: cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0030030 ! cell projection organization intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection relationship: BFO:0000050 GO:0000902 ! part of cell morphogenesis relationship: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection [Term] id: GO:0048859 name: formation of anatomical boundary namespace: biological_process def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0007651 ! results in formation of anatomical junction relationship: RO:0002297 UBERON:0007651 ! results in formation of anatomical junction [Term] id: GO:0048860 name: glioblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000030 ! has primary input glioblast relationship: RO:0004009 CL:0000030 ! has primary input glioblast [Term] id: GO:0048863 name: stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] xref: Wikipedia:Stem_cell_differentiation is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell relationship: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell [Term] id: GO:0048864 name: stem cell development namespace: biological_process def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000034 ! results in development of stem cell relationship: BFO:0000050 GO:0048863 ! part of stem cell differentiation relationship: RO:0002296 CL:0000034 ! results in development of stem cell [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] is_a: GO:0009987 ! cellular process is_a: GO:0032502 ! developmental process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_prokaryote synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0048871 name: multicellular organismal-level homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0042592 ! homeostatic process [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0048871 ! multicellular organismal-level homeostasis [Term] id: GO:0048873 name: homeostasis of number of cells within a tissue namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete] is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0048880 name: sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001032 ! results in development of sensory system relationship: RO:0002296 UBERON:0001032 ! results in development of sensory system [Term] id: GO:0048934 name: peripheral nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development relationship: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron [Term] id: GO:0048935 name: peripheral nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] is_a: GO:0048666 ! neuron development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron relationship: BFO:0000050 GO:0048934 ! part of peripheral nervous system neuron differentiation relationship: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron [Term] id: GO:0050000 name: chromosome localization namespace: biological_process def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chromosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005694 ! has primary input chromosome relationship: RO:0004009 GO:0005694 ! has primary input chromosome [Term] id: GO:0050432 name: catecholamine secretion namespace: biological_process def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:33567 ! has primary input [Term] id: GO:0050433 name: regulation of catecholamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050432 ! regulates catecholamine secretion relationship: RO:0002211 GO:0050432 ! regulates catecholamine secretion [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] is_a: GO:0015931 ! nucleobase-containing compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0050670 name: regulation of lymphocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046651 ! regulates lymphocyte proliferation relationship: RO:0002211 GO:0046651 ! regulates lymphocyte proliferation [Term] id: GO:0050671 name: positive regulation of lymphocyte proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "activation of lymphocyte proliferation" NARROW [] synonym: "stimulation of lymphocyte proliferation" NARROW [] synonym: "up regulation of lymphocyte proliferation" EXACT [] synonym: "up-regulation of lymphocyte proliferation" EXACT [] synonym: "upregulation of lymphocyte proliferation" EXACT [] is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051251 ! positive regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046651 ! positively regulates lymphocyte proliferation relationship: RO:0002213 GO:0046651 ! positively regulates lymphocyte proliferation [Term] id: GO:0050672 name: negative regulation of lymphocyte proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai] synonym: "down regulation of lymphocyte proliferation" EXACT [] synonym: "down-regulation of lymphocyte proliferation" EXACT [] synonym: "downregulation of lymphocyte proliferation" EXACT [] synonym: "inhibition of lymphocyte proliferation" NARROW [] is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0051250 ! negative regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046651 ! negatively regulates lymphocyte proliferation relationship: RO:0002212 GO:0046651 ! negatively regulates lymphocyte proliferation [Term] id: GO:0050673 name: epithelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000066 ! acts on population of epithelial cell relationship: RO:0012003 CL:0000066 ! acts on population of epithelial cell [Term] id: GO:0050678 name: regulation of epithelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation relationship: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation [Term] id: GO:0050679 name: positive regulation of epithelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "activation of epithelial cell proliferation" NARROW [] synonym: "stimulation of epithelial cell proliferation" NARROW [] synonym: "up regulation of epithelial cell proliferation" EXACT [] synonym: "up-regulation of epithelial cell proliferation" EXACT [] synonym: "upregulation of epithelial cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation relationship: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation [Term] id: GO:0050680 name: negative regulation of epithelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] synonym: "down regulation of epithelial cell proliferation" EXACT [] synonym: "down-regulation of epithelial cell proliferation" EXACT [] synonym: "downregulation of epithelial cell proliferation" EXACT [] synonym: "inhibition of epithelial cell proliferation" NARROW [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation relationship: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation [Term] id: GO:0050708 name: regulation of protein secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] is_a: GO:0051223 ! regulation of protein transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009306 ! regulates protein secretion relationship: RO:0002211 GO:0009306 ! regulates protein secretion [Term] id: GO:0050709 name: negative regulation of protein secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "down regulation of protein secretion" EXACT [] synonym: "down-regulation of protein secretion" EXACT [] synonym: "downregulation of protein secretion" EXACT [] synonym: "inhibition of protein secretion" NARROW [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051224 ! negative regulation of protein transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009306 ! negatively regulates protein secretion relationship: RO:0002212 GO:0009306 ! negatively regulates protein secretion [Term] id: GO:0050714 name: positive regulation of protein secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] synonym: "activation of protein secretion" NARROW [] synonym: "stimulation of protein secretion" NARROW [] synonym: "up regulation of protein secretion" EXACT [] synonym: "up-regulation of protein secretion" EXACT [] synonym: "upregulation of protein secretion" EXACT [] is_a: GO:0050708 ! regulation of protein secretion is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009306 ! positively regulates protein secretion relationship: RO:0002213 GO:0009306 ! positively regulates protein secretion [Term] id: GO:0050727 name: regulation of inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006954 ! regulates inflammatory response relationship: RO:0002211 GO:0006954 ! regulates inflammatory response [Term] id: GO:0050728 name: negative regulation of inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "anti-inflammatory response" EXACT [] synonym: "down regulation of inflammatory response" EXACT [] synonym: "down-regulation of inflammatory response" EXACT [] synonym: "downregulation of inflammatory response" EXACT [] synonym: "inhibition of inflammatory response" NARROW [] xref: Reactome:R-HSA-9018678 "Biosynthesis of specialized proresolving mediators (SPMs)" is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006954 ! negatively regulates inflammatory response relationship: RO:0002212 GO:0006954 ! negatively regulates inflammatory response [Term] id: GO:0050729 name: positive regulation of inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] synonym: "activation of inflammatory response" NARROW [] synonym: "stimulation of inflammatory response" NARROW [] synonym: "up regulation of inflammatory response" EXACT [] synonym: "up-regulation of inflammatory response" EXACT [] synonym: "upregulation of inflammatory response" EXACT [] is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006954 ! positively regulates inflammatory response relationship: RO:0002213 GO:0006954 ! positively regulates inflammatory response [Term] id: GO:0050764 name: regulation of phagocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] is_a: GO:0030100 ! regulation of endocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006909 ! regulates phagocytosis relationship: RO:0002211 GO:0006909 ! regulates phagocytosis [Term] id: GO:0050765 name: negative regulation of phagocytosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "down regulation of phagocytosis" EXACT [] synonym: "down-regulation of phagocytosis" EXACT [] synonym: "downregulation of phagocytosis" EXACT [] synonym: "inhibition of phagocytosis" NARROW [] is_a: GO:0045806 ! negative regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006909 ! negatively regulates phagocytosis relationship: RO:0002212 GO:0006909 ! negatively regulates phagocytosis [Term] id: GO:0050766 name: positive regulation of phagocytosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai] synonym: "activation of phagocytosis" NARROW [] synonym: "stimulation of phagocytosis" NARROW [] synonym: "up regulation of phagocytosis" EXACT [] synonym: "up-regulation of phagocytosis" EXACT [] synonym: "upregulation of phagocytosis" EXACT [] is_a: GO:0045807 ! positive regulation of endocytosis is_a: GO:0050764 ! regulation of phagocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006909 ! positively regulates phagocytosis relationship: RO:0002213 GO:0006909 ! positively regulates phagocytosis [Term] id: GO:0050767 name: regulation of neurogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022008 ! regulates neurogenesis relationship: RO:0002211 GO:0022008 ! regulates neurogenesis [Term] id: GO:0050768 name: negative regulation of neurogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "down regulation of neurogenesis" EXACT [] synonym: "down-regulation of neurogenesis" EXACT [] synonym: "downregulation of neurogenesis" EXACT [] synonym: "inhibition of neurogenesis" NARROW [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051961 ! negative regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022008 ! negatively regulates neurogenesis relationship: RO:0002212 GO:0022008 ! negatively regulates neurogenesis [Term] id: GO:0050769 name: positive regulation of neurogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] synonym: "activation of neurogenesis" NARROW [] synonym: "stimulation of neurogenesis" NARROW [] synonym: "up regulation of neurogenesis" EXACT [] synonym: "up-regulation of neurogenesis" EXACT [] synonym: "upregulation of neurogenesis" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0050767 ! regulation of neurogenesis is_a: GO:0051962 ! positive regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022008 ! positively regulates neurogenesis relationship: RO:0002213 GO:0022008 ! positively regulates neurogenesis [Term] id: GO:0050770 name: regulation of axonogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] xref: Reactome:R-HSA-193697 "p75NTR regulates axonogenesis" is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007409 ! regulates axonogenesis relationship: RO:0002211 GO:0007409 ! regulates axonogenesis [Term] id: GO:0050771 name: negative regulation of axonogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "down regulation of axonogenesis" EXACT [] synonym: "down-regulation of axonogenesis" EXACT [] synonym: "downregulation of axonogenesis" EXACT [] synonym: "inhibition of axonogenesis" NARROW [] xref: Reactome:R-HSA-193634 "Axonal growth inhibition (RHOA activation)" is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007409 ! negatively regulates axonogenesis relationship: RO:0002212 GO:0007409 ! negatively regulates axonogenesis [Term] id: GO:0050772 name: positive regulation of axonogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] synonym: "activation of axonogenesis" NARROW [] synonym: "stimulation of axonogenesis" NARROW [] synonym: "up regulation of axonogenesis" EXACT [] synonym: "up-regulation of axonogenesis" EXACT [] synonym: "upregulation of axonogenesis" EXACT [] xref: Reactome:R-HSA-209563 "Axonal growth stimulation" is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:0050770 ! regulation of axonogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007409 ! positively regulates axonogenesis relationship: RO:0002213 GO:0007409 ! positively regulates axonogenesis [Term] id: GO:0050773 name: regulation of dendrite development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016358 ! regulates dendrite development relationship: RO:0002211 GO:0016358 ! regulates dendrite development [Term] id: GO:0050774 name: negative regulation of dendrite morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "down regulation of dendrite morphogenesis" EXACT [] synonym: "down-regulation of dendrite morphogenesis" EXACT [] synonym: "downregulation of dendrite morphogenesis" EXACT [] synonym: "inhibition of dendrite morphogenesis" NARROW [] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048813 ! negatively regulates dendrite morphogenesis relationship: RO:0002212 GO:0048813 ! negatively regulates dendrite morphogenesis [Term] id: GO:0050775 name: positive regulation of dendrite morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] synonym: "activation of dendrite morphogenesis" NARROW [] synonym: "stimulation of dendrite morphogenesis" NARROW [] synonym: "up regulation of dendrite morphogenesis" EXACT [] synonym: "up-regulation of dendrite morphogenesis" EXACT [] synonym: "upregulation of dendrite morphogenesis" EXACT [] is_a: GO:0010770 ! positive regulation of cell morphogenesis is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048813 ! positively regulates dendrite morphogenesis relationship: RO:0002213 GO:0048813 ! positively regulates dendrite morphogenesis [Term] id: GO:0050776 name: regulation of immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] xref: Reactome:R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006955 ! regulates immune response relationship: RO:0002211 GO:0006955 ! regulates immune response [Term] id: GO:0050777 name: negative regulation of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "down regulation of immune response" EXACT [] synonym: "down-regulation of immune response" EXACT [] synonym: "downregulation of immune response" EXACT [] synonym: "inhibition of immune response" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006955 ! negatively regulates immune response relationship: RO:0002212 GO:0006955 ! negatively regulates immune response [Term] id: GO:0050778 name: positive regulation of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] synonym: "stimulation of immune response" NARROW [] synonym: "up regulation of immune response" EXACT [] synonym: "up-regulation of immune response" EXACT [] synonym: "upregulation of immune response" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006955 ! positively regulates immune response relationship: RO:0002213 GO:0006955 ! positively regulates immune response [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: gocheck_do_not_annotate subset: goslim_candida subset: goslim_pir synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008150 ! regulates biological_process relationship: RO:0002211 GO:0008150 ! regulates biological_process [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: gocheck_obsoletion_candidate subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003824 ! regulates catalytic activity relationship: RO:0002211 GO:0003824 ! regulates catalytic activity [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032502 ! regulates developmental process relationship: RO:0002211 GO:0032502 ! regulates developmental process [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] subset: gocheck_do_not_annotate synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009987 ! regulates cellular process relationship: RO:0002211 GO:0009987 ! regulates cellular process [Term] id: GO:0050795 name: regulation of behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007610 ! regulates behavior relationship: RO:0002211 GO:0007610 ! regulates behavior [Term] id: GO:0050803 name: regulation of synapse structure or activity namespace: biological_process def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] is_a: GO:0065008 ! regulation of biological quality relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0050804 name: modulation of chemical synaptic transmission namespace: biological_process def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai] subset: goslim_synapse synonym: "modulation of synaptic transmission" BROAD [] synonym: "regulation of chemical synaptic transmission" EXACT [] synonym: "regulation of synaptic transmission" EXACT [] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0050805 name: negative regulation of synaptic transmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "down regulation of synaptic transmission" EXACT [] synonym: "down-regulation of synaptic transmission" EXACT [] synonym: "downregulation of synaptic transmission" EXACT [] synonym: "inhibition of synaptic transmission" NARROW [] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission relationship: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission [Term] id: GO:0050806 name: positive regulation of synaptic transmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] synonym: "activation of synaptic transmission" NARROW [] synonym: "stimulation of synaptic transmission" NARROW [] synonym: "up regulation of synaptic transmission" EXACT [] synonym: "up-regulation of synaptic transmission" EXACT [] synonym: "upregulation of synaptic transmission" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission relationship: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission [Term] id: GO:0050807 name: regulation of synapse organization namespace: biological_process def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of synapse organisation" EXACT [GOC:mah] synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of synapse structure" EXACT [] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050808 ! regulates synapse organization relationship: BFO:0000050 GO:0050803 ! part of regulation of synapse structure or activity relationship: RO:0002211 GO:0050808 ! regulates synapse organization [Term] id: GO:0050808 name: synapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] subset: goslim_drosophila subset: goslim_synapse synonym: "synapse development" RELATED [GOC:aruk] synonym: "synapse morphogenesis" RELATED [GOC:BHF] synonym: "synapse organisation" EXACT [] synonym: "synapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0034330 ! cell junction organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0045202 ! results in organization of synapse relationship: RO:0002592 GO:0045202 ! results in organization of synapse [Term] id: GO:0050810 name: regulation of steroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] synonym: "regulation of steroid anabolism" EXACT [] synonym: "regulation of steroid biosynthesis" EXACT [] synonym: "regulation of steroid formation" EXACT [] synonym: "regulation of steroid synthesis" EXACT [] synonym: "regulation of steroidogenesis" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process relationship: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process [Term] id: GO:0050832 name: defense response to fungus namespace: biological_process def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] synonym: "defence response to fungi" EXACT [] synonym: "defence response to fungus" EXACT [] synonym: "defense response to fungi" EXACT [] synonym: "defense response to fungus, incompatible interaction" NARROW [] synonym: "resistance response to pathogenic fungi" NARROW [] synonym: "resistance response to pathogenic fungus" NARROW [] synonym: "response to parasitic fungi" NARROW [] synonym: "response to parasitic fungus" NARROW [] is_a: GO:0006952 ! defense response is_a: GO:0009620 ! response to fungus intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi [Term] id: GO:0050839 name: cell adhesion molecule binding namespace: molecular_function def: "Binding to a cell adhesion molecule." [GOC:ai] synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "CAM binding" EXACT [] synonym: "cell adhesion molecule activity" RELATED [] synonym: "cell adhesion receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0050840 name: extracellular matrix binding namespace: molecular_function def: "Binding to a component of the extracellular matrix." [GOC:ai] subset: goslim_chembl subset: goslim_pir synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0031012 ! has primary input extracellular matrix relationship: RO:0004009 GO:0031012 ! has primary input extracellular matrix [Term] id: GO:0050863 name: regulation of T cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "regulation of T lymphocyte activation" EXACT [] synonym: "regulation of T-cell activation" EXACT [] synonym: "regulation of T-lymphocyte activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042110 ! regulates T cell activation relationship: RO:0002211 GO:0042110 ! regulates T cell activation [Term] id: GO:0050865 name: regulation of cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001775 ! regulates cell activation relationship: RO:0002211 GO:0001775 ! regulates cell activation [Term] id: GO:0050866 name: negative regulation of cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] synonym: "down regulation of cell activation" EXACT [] synonym: "down-regulation of cell activation" EXACT [] synonym: "downregulation of cell activation" EXACT [] synonym: "inhibition of cell activation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0050865 ! regulation of cell activation is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001775 ! negatively regulates cell activation relationship: RO:0002212 GO:0001775 ! negatively regulates cell activation [Term] id: GO:0050867 name: positive regulation of cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] synonym: "activation of cell activation" NARROW [] synonym: "stimulation of cell activation" NARROW [] synonym: "up regulation of cell activation" EXACT [] synonym: "up-regulation of cell activation" EXACT [] synonym: "upregulation of cell activation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0050865 ! regulation of cell activation is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001775 ! positively regulates cell activation relationship: RO:0002213 GO:0001775 ! positively regulates cell activation [Term] id: GO:0050868 name: negative regulation of T cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "down regulation of T cell activation" EXACT [] synonym: "down-regulation of T cell activation" EXACT [] synonym: "downregulation of T cell activation" EXACT [] synonym: "inhibition of T cell activation" NARROW [] synonym: "negative regulation of T lymphocyte activation" EXACT [] synonym: "negative regulation of T-cell activation" EXACT [] synonym: "negative regulation of T-lymphocyte activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042110 ! negatively regulates T cell activation relationship: RO:0002212 GO:0042110 ! negatively regulates T cell activation [Term] id: GO:0050870 name: positive regulation of T cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai] synonym: "activation of T cell activation" NARROW [] synonym: "positive regulation of T lymphocyte activation" EXACT [] synonym: "positive regulation of T-cell activation" EXACT [] synonym: "positive regulation of T-lymphocyte activation" EXACT [] synonym: "stimulation of T cell activation" NARROW [] synonym: "up regulation of T cell activation" EXACT [] synonym: "up-regulation of T cell activation" EXACT [] synonym: "upregulation of T cell activation" EXACT [] is_a: GO:0050863 ! regulation of T cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042110 ! positively regulates T cell activation relationship: RO:0002213 GO:0042110 ! positively regulates T cell activation [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "An organ system process carried out by any of the organs or tissues of the neurological system." [GOC:ai, GOC:mtg_cardio] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: GO:0003008 ! system process intersection_of: GO:0003008 ! system process intersection_of: RO:0000057 UBERON:0001016 ! has participant nervous system relationship: RO:0000057 UBERON:0001016 ! has participant nervous system relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0050878 name: regulation of body fluid levels namespace: biological_process def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0050879 name: multicellular organismal movement namespace: biological_process def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0050881 name: musculoskeletal movement namespace: biological_process def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] is_a: GO:0050879 ! multicellular organismal movement is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0050886 name: endocrine process namespace: biological_process def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544] subset: goslim_generic subset: goslim_pir synonym: "endocrine physiological process" EXACT [] synonym: "endocrine physiology" EXACT [] is_a: GO:0003008 ! system process [Term] id: GO:0050890 name: cognition namespace: biological_process def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908] subset: goslim_drosophila xref: Wikipedia:Cognition is_a: GO:0050877 ! nervous system process [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_prokaryote subset: goslim_prokaryote_ribbon synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050900 name: leukocyte migration namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration" EXACT [] synonym: "immune cell trafficking" EXACT [] synonym: "leucocyte migration" EXACT [] synonym: "leucocyte trafficking" EXACT [] synonym: "leukocyte trafficking" EXACT [] xref: Reactome:R-HSA-202733 "Cell surface interactions at the vascular wall" is_a: GO:0002376 ! immune system process is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002565 CL:0000738 ! results in movement of leukocyte [Term] id: GO:0050905 name: neuromuscular process namespace: biological_process def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] synonym: "neuromotor process" EXACT [] synonym: "neuromuscular physiological process" EXACT [] is_a: GO:0050877 ! nervous system process [Term] id: GO:0050906 name: detection of stimulus involved in sensory perception namespace: biological_process def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph] synonym: "sensory detection of stimulus" EXACT [] synonym: "sensory perception, sensory transduction of stimulus" EXACT [] synonym: "sensory perception, stimulus detection" EXACT [] synonym: "sensory transduction" EXACT [] xref: Wikipedia:Transduction_(physiology) is_a: GO:0051606 ! detection of stimulus intersection_of: GO:0051606 ! detection of stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0007600 ! part of sensory perception [Term] id: GO:0050907 name: detection of chemical stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] synonym: "sensory detection of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus" EXACT [] synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0007606 ! part of sensory perception of chemical stimulus [Term] id: GO:0050908 name: detection of light stimulus involved in visual perception namespace: biological_process def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] synonym: "sensory detection of light during visual perception" EXACT [] synonym: "sensory detection of light stimulus during visual perception" EXACT [] synonym: "sensory transduction of light during visual perception" EXACT [] synonym: "sensory transduction of light stimulus during visual perception" EXACT [] synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: BFO:0000050 GO:0007601 ! part of visual perception relationship: BFO:0000050 GO:0007601 ! part of visual perception [Term] id: GO:0050909 name: sensory perception of taste namespace: biological_process def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai] synonym: "gustation" EXACT [] synonym: "sense of taste" EXACT [] synonym: "taste" EXACT [] synonym: "taste perception" EXACT [] xref: Reactome:R-HSA-9717189 "Sensory perception of taste" xref: Wikipedia:Taste is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0050912 name: detection of chemical stimulus involved in sensory perception of taste namespace: biological_process def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "perception of taste, detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory detection of chemical stimulus" EXACT [] synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of taste" EXACT [] synonym: "sensory detection of taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT [] synonym: "sensory transduction of taste" EXACT [] synonym: "taste perception" BROAD [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0050909 ! part of sensory perception of taste relationship: BFO:0000050 GO:0050909 ! part of sensory perception of taste [Term] id: GO:0050920 name: regulation of chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0040012 ! regulation of locomotion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006935 ! regulates chemotaxis relationship: RO:0002211 GO:0006935 ! regulates chemotaxis [Term] id: GO:0050921 name: positive regulation of chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "activation of chemotaxis" NARROW [] synonym: "stimulation of chemotaxis" NARROW [] synonym: "up regulation of chemotaxis" EXACT [] synonym: "up-regulation of chemotaxis" EXACT [] synonym: "upregulation of chemotaxis" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006935 ! positively regulates chemotaxis relationship: RO:0002213 GO:0006935 ! positively regulates chemotaxis [Term] id: GO:0050922 name: negative regulation of chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] synonym: "down regulation of chemotaxis" EXACT [] synonym: "down-regulation of chemotaxis" EXACT [] synonym: "downregulation of chemotaxis" EXACT [] synonym: "inhibition of chemotaxis" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006935 ! negatively regulates chemotaxis relationship: RO:0002212 GO:0006935 ! negatively regulates chemotaxis [Term] id: GO:0050931 name: pigment cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. synonym: "chromatophore differentiation" EXACT [] synonym: "pigmented cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell relationship: BFO:0000050 GO:0048066 ! part of developmental pigmentation relationship: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell [Term] id: GO:0050932 name: regulation of pigment cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050931 ! regulates pigment cell differentiation relationship: RO:0002211 GO:0050931 ! regulates pigment cell differentiation [Term] id: GO:0050941 name: negative regulation of pigment cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "down regulation of pigment cell differentiation" EXACT [] synonym: "down-regulation of pigment cell differentiation" EXACT [] synonym: "downregulation of pigment cell differentiation" EXACT [] synonym: "inhibition of pigment cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0048086 ! negative regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation relationship: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation [Term] id: GO:0050942 name: positive regulation of pigment cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] synonym: "activation of pigment cell differentiation" NARROW [] synonym: "stimulation of pigment cell differentiation" NARROW [] synonym: "up regulation of pigment cell differentiation" EXACT [] synonym: "up-regulation of pigment cell differentiation" EXACT [] synonym: "upregulation of pigment cell differentiation" EXACT [] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0048087 ! positive regulation of developmental pigmentation is_a: GO:0050932 ! regulation of pigment cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation relationship: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation [Term] id: GO:0050953 name: sensory perception of light stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050954 name: sensory perception of mechanical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanosensory perception" EXACT [] synonym: "perception of mechanical stimulus" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0050962 name: detection of light stimulus involved in sensory perception namespace: biological_process def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] synonym: "sensory detection of light stimulus" EXACT [] synonym: "sensory detection of light stimulus during sensory perception" EXACT [] synonym: "sensory perception, sensory detection of light stimulus" EXACT [] synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus" EXACT [] synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] is_a: GO:0009583 ! detection of light stimulus is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception relationship: BFO:0000050 GO:0050953 ! part of sensory perception of light stimulus [Term] id: GO:0050968 name: detection of chemical stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai] synonym: "chemical nociception" RELATED [GOC:pr] synonym: "perception of pain, detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain intersection_of: GO:0009593 ! detection of chemical stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain [Term] id: GO:0050975 name: sensory perception of touch namespace: biological_process def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] synonym: "perception of touch" EXACT [] synonym: "tactile sense" EXACT [] synonym: "taction" EXACT [] synonym: "tactition" EXACT [] xref: Wikipedia:Touch is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0050994 name: regulation of lipid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "regulation of lipid breakdown" EXACT [] synonym: "regulation of lipid catabolism" EXACT [] synonym: "regulation of lipid degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016042 ! regulates lipid catabolic process relationship: RO:0002211 GO:0016042 ! regulates lipid catabolic process [Term] id: GO:0050995 name: negative regulation of lipid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "down regulation of lipid catabolic process" EXACT [] synonym: "down-regulation of lipid catabolic process" EXACT [] synonym: "downregulation of lipid catabolic process" EXACT [] synonym: "inhibition of lipid catabolic process" NARROW [] synonym: "negative regulation of lipid breakdown" EXACT [] synonym: "negative regulation of lipid catabolism" EXACT [] synonym: "negative regulation of lipid degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process relationship: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process [Term] id: GO:0050996 name: positive regulation of lipid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] synonym: "activation of lipid catabolic process" NARROW [] synonym: "positive regulation of lipid breakdown" EXACT [] synonym: "positive regulation of lipid catabolism" EXACT [] synonym: "positive regulation of lipid degradation" EXACT [] synonym: "stimulation of lipid catabolic process" NARROW [] synonym: "up regulation of lipid catabolic process" EXACT [] synonym: "up-regulation of lipid catabolic process" EXACT [] synonym: "upregulation of lipid catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045834 ! positive regulation of lipid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process relationship: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process [Term] id: GO:0051017 name: actin filament bundle assembly namespace: biological_process def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] synonym: "actin bundling activity" RELATED [] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061572 ! actin filament bundle organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle relationship: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle [Term] id: GO:0051027 name: DNA transport namespace: biological_process def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0051032 name: nucleic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: BFO:0000050 GO:0050657 ! part of nucleic acid transport relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid [Term] id: GO:0051033 name: RNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol" is_a: GO:0051032 ! nucleic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: BFO:0000050 GO:0050658 ! part of RNA transport relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid [Term] id: GO:0051035 name: DNA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0051032 ! nucleic acid transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: BFO:0000050 GO:0051027 ! part of DNA transport relationship: RO:0004009 CHEBI:16991 ! has primary input [Term] id: GO:0051046 name: regulation of secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046903 ! regulates secretion relationship: RO:0002211 GO:0046903 ! regulates secretion [Term] id: GO:0051047 name: positive regulation of secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "activation of secretion" NARROW [] synonym: "stimulation of secretion" NARROW [] synonym: "up regulation of secretion" EXACT [] synonym: "up-regulation of secretion" EXACT [] synonym: "upregulation of secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051050 ! positive regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046903 ! positively regulates secretion relationship: RO:0002213 GO:0046903 ! positively regulates secretion [Term] id: GO:0051048 name: negative regulation of secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] synonym: "down regulation of secretion" EXACT [] synonym: "down-regulation of secretion" EXACT [] synonym: "downregulation of secretion" EXACT [] synonym: "inhibition of secretion" NARROW [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051051 ! negative regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046903 ! negatively regulates secretion relationship: RO:0002212 GO:0046903 ! negatively regulates secretion [Term] id: GO:0051049 name: regulation of transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_yeast is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006810 ! regulates transport relationship: RO:0002211 GO:0006810 ! regulates transport [Term] id: GO:0051050 name: positive regulation of transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of transport" NARROW [] synonym: "stimulation of transport" NARROW [] synonym: "up regulation of transport" EXACT [] synonym: "up-regulation of transport" EXACT [] synonym: "upregulation of transport" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006810 ! positively regulates transport relationship: RO:0002213 GO:0006810 ! positively regulates transport [Term] id: GO:0051051 name: negative regulation of transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of transport" EXACT [] synonym: "down-regulation of transport" EXACT [] synonym: "downregulation of transport" EXACT [] synonym: "inhibition of transport" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006810 ! negatively regulates transport relationship: RO:0002212 GO:0006810 ! negatively regulates transport [Term] id: GO:0051052 name: regulation of DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: goslim_yeast synonym: "regulation of DNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006259 ! regulates DNA metabolic process relationship: RO:0002211 GO:0006259 ! regulates DNA metabolic process [Term] id: GO:0051053 name: negative regulation of DNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "down regulation of DNA metabolic process" EXACT [] synonym: "down-regulation of DNA metabolic process" EXACT [] synonym: "downregulation of DNA metabolic process" EXACT [] synonym: "inhibition of DNA metabolic process" NARROW [] synonym: "negative regulation of DNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006259 ! negatively regulates DNA metabolic process relationship: RO:0002212 GO:0006259 ! negatively regulates DNA metabolic process [Term] id: GO:0051054 name: positive regulation of DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] synonym: "activation of DNA metabolic process" NARROW [] synonym: "positive regulation of DNA metabolism" EXACT [] synonym: "stimulation of DNA metabolic process" NARROW [] synonym: "up regulation of DNA metabolic process" EXACT [] synonym: "up-regulation of DNA metabolic process" EXACT [] synonym: "upregulation of DNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006259 ! positively regulates DNA metabolic process relationship: RO:0002213 GO:0006259 ! positively regulates DNA metabolic process [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] synonym: "down regulation of lipid biosynthetic process" EXACT [] synonym: "down-regulation of lipid biosynthetic process" EXACT [] synonym: "downregulation of lipid biosynthetic process" EXACT [] synonym: "inhibition of lipid biosynthetic process" NARROW [] synonym: "negative regulation of lipid anabolism" EXACT [] synonym: "negative regulation of lipid biosynthesis" EXACT [] synonym: "negative regulation of lipid formation" EXACT [] synonym: "negative regulation of lipid synthesis" EXACT [] synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045833 ! negative regulation of lipid metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process relationship: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process [Term] id: GO:0051059 name: NF-kappaB binding namespace: molecular_function def: "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 PR:000001753 ! has primary input transcription factor NF-kappa-B subunit relationship: RO:0004009 PR:000001753 ! has primary input transcription factor NF-kappa-B subunit [Term] id: GO:0051078 name: meiotic nuclear membrane disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf] synonym: "meiotic nuclear envelope breakdown" RELATED [] synonym: "meiotic nuclear envelope catabolism" RELATED [] synonym: "meiotic nuclear envelope degradation" RELATED [] synonym: "meiotic nuclear envelope disassembly" RELATED [] is_a: GO:0051081 ! nuclear membrane disassembly is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0051080 name: meiosis II nuclear membrane disassembly namespace: biological_process def: "The controlled breakdown of the nuclear membranes during the second division of meiosis." [GOC:bf] synonym: "meiosis II nuclear envelope breakdown" RELATED [] synonym: "meiosis II nuclear envelope catabolism" RELATED [] synonym: "meiosis II nuclear envelope degradation" RELATED [] synonym: "meiosis II nuclear envelope disassembly" RELATED [] is_a: GO:0051078 ! meiotic nuclear membrane disassembly intersection_of: GO:0051081 ! nuclear membrane disassembly intersection_of: BFO:0000050 GO:0007135 ! part of meiosis II relationship: BFO:0000050 GO:0007135 ! part of meiosis II [Term] id: GO:0051081 name: nuclear membrane disassembly namespace: biological_process def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai] synonym: "nuclear envelope breakdown" RELATED [] synonym: "nuclear envelope catabolism" RELATED [] synonym: "nuclear envelope degradation" RELATED [] synonym: "nuclear envelope disassembly" RELATED [] is_a: GO:0030397 ! membrane disassembly is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane relationship: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane [Term] id: GO:0051093 name: negative regulation of developmental process namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "down regulation of developmental process" EXACT [] synonym: "down-regulation of developmental process" EXACT [] synonym: "downregulation of developmental process" EXACT [] synonym: "inhibition of developmental process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032502 ! negatively regulates developmental process relationship: RO:0002212 GO:0032502 ! negatively regulates developmental process [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032502 ! positively regulates developmental process relationship: RO:0002213 GO:0032502 ! positively regulates developmental process [Term] id: GO:0051098 name: regulation of binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gocheck_do_not_annotate is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005488 ! regulates binding relationship: RO:0002211 GO:0005488 ! regulates binding [Term] id: GO:0051099 name: positive regulation of binding namespace: biological_process def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gocheck_do_not_annotate synonym: "activation of binding" NARROW [] synonym: "stimulation of binding" NARROW [] synonym: "up regulation of binding" EXACT [] synonym: "up-regulation of binding" EXACT [] synonym: "upregulation of binding" EXACT [] is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005488 ! positively regulates binding relationship: RO:0002213 GO:0005488 ! positively regulates binding [Term] id: GO:0051100 name: negative regulation of binding namespace: biological_process def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] subset: gocheck_do_not_annotate synonym: "down regulation of binding" EXACT [] synonym: "down-regulation of binding" EXACT [] synonym: "downregulation of binding" EXACT [] synonym: "inhibition of binding" NARROW [] is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005488 ! negatively regulates binding relationship: RO:0002212 GO:0005488 ! negatively regulates binding [Term] id: GO:0051101 name: regulation of DNA binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] subset: gocheck_do_not_annotate is_a: GO:0051098 ! regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003677 ! regulates DNA binding relationship: RO:0002211 GO:0003677 ! regulates DNA binding [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] subset: gocheck_do_not_annotate synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016043 ! regulates cellular component organization relationship: RO:0002211 GO:0016043 ! regulates cellular component organization [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016043 ! negatively regulates cellular component organization relationship: RO:0002212 GO:0016043 ! negatively regulates cellular component organization [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016043 ! positively regulates cellular component organization relationship: RO:0002213 GO:0016043 ! positively regulates cellular component organization [Term] id: GO:0051145 name: smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] synonym: "nonstriated muscle cell differentiation" EXACT [] is_a: GO:0042692 ! muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell relationship: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell [Term] id: GO:0051146 name: striated muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] synonym: "voluntary muscle cell differentiation" NARROW [] is_a: GO:0042692 ! muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell relationship: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell [Term] id: GO:0051147 name: regulation of muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042692 ! regulates muscle cell differentiation relationship: RO:0002211 GO:0042692 ! regulates muscle cell differentiation [Term] id: GO:0051148 name: negative regulation of muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "down regulation of muscle cell differentiation" EXACT [] synonym: "down-regulation of muscle cell differentiation" EXACT [] synonym: "downregulation of muscle cell differentiation" EXACT [] synonym: "inhibition of muscle cell differentiation" NARROW [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation relationship: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation [Term] id: GO:0051149 name: positive regulation of muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] synonym: "activation of muscle cell differentiation" NARROW [] synonym: "stimulation of muscle cell differentiation" NARROW [] synonym: "up regulation of muscle cell differentiation" EXACT [] synonym: "up-regulation of muscle cell differentiation" EXACT [] synonym: "upregulation of muscle cell differentiation" EXACT [] xref: Reactome:R-HSA-525793 "Myogenesis" is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation relationship: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation [Term] id: GO:0051150 name: regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation relationship: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation [Term] id: GO:0051151 name: negative regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "down regulation of smooth muscle cell differentiation" EXACT [] synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] synonym: "downregulation of smooth muscle cell differentiation" EXACT [] synonym: "inhibition of smooth muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation relationship: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation [Term] id: GO:0051152 name: positive regulation of smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] synonym: "activation of smooth muscle cell differentiation" NARROW [] synonym: "stimulation of smooth muscle cell differentiation" NARROW [] synonym: "up regulation of smooth muscle cell differentiation" EXACT [] synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] synonym: "upregulation of smooth muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation relationship: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation [Term] id: GO:0051153 name: regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] is_a: GO:0051147 ! regulation of muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation relationship: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation [Term] id: GO:0051154 name: negative regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "down regulation of striated muscle cell differentiation" EXACT [] synonym: "down-regulation of striated muscle cell differentiation" EXACT [] synonym: "downregulation of striated muscle cell differentiation" EXACT [] synonym: "inhibition of striated muscle cell differentiation" NARROW [] is_a: GO:0051148 ! negative regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation relationship: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation [Term] id: GO:0051155 name: positive regulation of striated muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] synonym: "activation of striated muscle cell differentiation" NARROW [] synonym: "stimulation of striated muscle cell differentiation" NARROW [] synonym: "up regulation of striated muscle cell differentiation" EXACT [] synonym: "up-regulation of striated muscle cell differentiation" EXACT [] synonym: "upregulation of striated muscle cell differentiation" EXACT [] is_a: GO:0051149 ! positive regulation of muscle cell differentiation is_a: GO:0051153 ! regulation of striated muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation relationship: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation [Term] id: GO:0051168 name: nuclear export namespace: biological_process def: "The directed movement of substances out of the nucleus." [GOC:ai] synonym: "export from nucleus" EXACT [] synonym: "nucleus export" EXACT [] synonym: "substance nuclear export" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope relationship: RO:0002338 GO:0031981 ! has target start location nuclear lumen relationship: RO:0002339 GO:0005829 ! has target end location cytosol [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] subset: goslim_yeast synonym: "nucleus transport" EXACT [] xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0002344 GO:0005634 ! results in transport to from or in nucleus intersection_of: RO:0002344 GO:0005634 ! results in transport to from or in nucleus relationship: RO:0002344 GO:0005634 ! results in transport to from or in nucleus [Term] id: GO:0051170 name: import into nucleus namespace: biological_process def: "The directed movement of substances into the nucleus." [GOC:ai] synonym: "nuclear import" EXACT [] synonym: "nuclear translocation" EXACT [] is_a: GO:0006913 ! nucleocytoplasmic transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0031981 ! has target end location nuclear lumen creation_date: 2013-12-19T15:26:34Z [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006793 ! regulates phosphorus metabolic process relationship: RO:0002211 GO:0006793 ! regulates phosphorus metabolic process [Term] id: GO:0051179 name: localization namespace: biological_process alt_id: GO:1902578 def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] synonym: "single organism localization" RELATED [GOC:TermGenie] synonym: "single-organism localization" RELATED [] is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:0051216 name: cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424] synonym: "cartilage biogenesis" EXACT [] synonym: "cartilage biosynthesis" EXACT [] synonym: "cartilage element development" EXACT [] synonym: "cartilage formation" EXACT [] synonym: "cartilage organ development" EXACT [] synonym: "chondrogenesis" EXACT [] xref: Wikipedia:Chondrogenesis is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0007844 ! results in development of cartilage element relationship: BFO:0000050 GO:0001501 ! part of skeletal system development relationship: BFO:0000050 GO:0061448 ! part of connective tissue development relationship: RO:0002296 UBERON:0007844 ! results in development of cartilage element [Term] id: GO:0051222 name: positive regulation of protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of protein transport" NARROW [] synonym: "stimulation of protein transport" NARROW [] synonym: "up regulation of protein transport" EXACT [] synonym: "up-regulation of protein transport" EXACT [] synonym: "upregulation of protein transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015031 ! positively regulates protein transport relationship: RO:0002213 GO:0015031 ! positively regulates protein transport [Term] id: GO:0051223 name: regulation of protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015031 ! regulates protein transport relationship: RO:0002211 GO:0015031 ! regulates protein transport [Term] id: GO:0051224 name: negative regulation of protein transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of protein transport" EXACT [] synonym: "down-regulation of protein transport" EXACT [] synonym: "downregulation of protein transport" EXACT [] synonym: "inhibition of protein transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051223 ! regulation of protein transport is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015031 ! negatively regulates protein transport relationship: RO:0002212 GO:0015031 ! negatively regulates protein transport [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] subset: gocheck_do_not_annotate subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0051235 name: maintenance of location namespace: biological_process def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of localization" EXACT [] synonym: "retention" NARROW [] synonym: "sequestering" NARROW [] synonym: "storage" NARROW [] is_a: GO:0051179 ! localization [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: BFO:0000050 GO:0006403 ! part of RNA localization [Term] id: GO:0051239 name: regulation of multicellular organismal process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032501 ! regulates multicellular organismal process relationship: RO:0002211 GO:0032501 ! regulates multicellular organismal process [Term] id: GO:0051240 name: positive regulation of multicellular organismal process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "activation of multicellular organismal process" NARROW [] synonym: "stimulation of multicellular organismal process" NARROW [] synonym: "up regulation of multicellular organismal process" EXACT [] synonym: "up-regulation of multicellular organismal process" EXACT [] synonym: "upregulation of multicellular organismal process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process relationship: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process [Term] id: GO:0051241 name: negative regulation of multicellular organismal process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] synonym: "down regulation of multicellular organismal process" EXACT [] synonym: "down-regulation of multicellular organismal process" EXACT [] synonym: "downregulation of multicellular organismal process" EXACT [] synonym: "inhibition of multicellular organismal process" NARROW [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process relationship: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process alt_id: GO:0032268 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "regulation of cellular protein metabolic process" RELATED [] synonym: "regulation of cellular protein metabolism" RELATED [] synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019538 ! regulates protein metabolic process relationship: RO:0002211 GO:0019538 ! regulates protein metabolic process [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolic process" EXACT [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019538 ! positively regulates protein metabolic process relationship: RO:0002213 GO:0019538 ! positively regulates protein metabolic process [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolic process" EXACT [] synonym: "negative regulation of cellular protein metabolism" EXACT [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process relationship: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process [Term] id: GO:0051249 name: regulation of lymphocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] is_a: GO:0002694 ! regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046649 ! regulates lymphocyte activation relationship: RO:0002211 GO:0046649 ! regulates lymphocyte activation [Term] id: GO:0051250 name: negative regulation of lymphocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "down regulation of lymphocyte activation" EXACT [] synonym: "down-regulation of lymphocyte activation" EXACT [] synonym: "downregulation of lymphocyte activation" EXACT [] synonym: "inhibition of lymphocyte activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0046649 ! negatively regulates lymphocyte activation relationship: RO:0002212 GO:0046649 ! negatively regulates lymphocyte activation [Term] id: GO:0051251 name: positive regulation of lymphocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] synonym: "activation of lymphocyte activation" NARROW [] synonym: "stimulation of lymphocyte activation" NARROW [] synonym: "up regulation of lymphocyte activation" EXACT [] synonym: "up-regulation of lymphocyte activation" EXACT [] synonym: "upregulation of lymphocyte activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0051249 ! regulation of lymphocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0046649 ! positively regulates lymphocyte activation relationship: RO:0002213 GO:0046649 ! positively regulates lymphocyte activation [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016070 ! regulates RNA metabolic process relationship: RO:0002211 GO:0016070 ! regulates RNA metabolic process [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process relationship: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process relationship: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process [Term] id: GO:0051258 name: protein polymerization namespace: biological_process def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer biosynthesis" EXACT [] synonym: "protein polymer biosynthetic process" EXACT [] synonym: "protein polymer formation" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0051261 name: protein depolymerization namespace: biological_process def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir synonym: "protein polymer breakdown" EXACT [] synonym: "protein polymer catabolic process" EXACT [] synonym: "protein polymer catabolism" EXACT [] synonym: "protein polymer degradation" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0051276 name: chromosome organization namespace: biological_process def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "DNA condensation" EXACT [] synonym: "DNA packaging" NARROW [] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005694 ! results in organization of chromosome relationship: RO:0002592 GO:0005694 ! results in organization of chromosome [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_drosophila subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0009987 ! cellular process [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051301 ! regulates cell division relationship: RO:0002211 GO:0051301 ! regulates cell division [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process alt_id: GO:0007126 def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. subset: goslim_drosophila subset: goslim_yeast synonym: "meiosis" RELATED [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle is_a: GO:0022414 ! reproductive process intersection_of: GO:0007049 ! cell cycle intersection_of: BFO:0000051 GO:0140013 ! has part meiotic nuclear division relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction relationship: BFO:0000051 GO:0140013 ! has part meiotic nuclear division [Term] id: GO:0051326 name: telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Telophase is_a: GO:0022403 ! cell cycle phase relationship: BFO:0000050 GO:0000279 ! part of M phase [Term] id: GO:0051327 name: meiotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of meiotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: RO:0002092 GO:0051321 ! happens during meiotic cell cycle [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016787 ! regulates hydrolase activity relationship: RO:0002211 GO:0016787 ! regulates hydrolase activity [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_obsoletion_candidate synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016740 ! regulates transferase activity relationship: RO:0002211 GO:0016740 ! regulates transferase activity [Term] id: GO:0051378 name: serotonin binding namespace: molecular_function def: "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] synonym: "5-hydroxytryptamine binding" EXACT [] is_a: GO:0043169 ! cation binding is_a: GO:0043176 ! amine binding is_a: GO:1901363 ! heterocyclic compound binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0051380 name: norepinephrine binding namespace: molecular_function def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "noradrenaline binding" EXACT [] is_a: GO:0043169 ! cation binding is_a: GO:1901338 ! catecholamine binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0051402 name: neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] synonym: "apoptosis of neuronal cells" EXACT [] synonym: "apoptosis of neurons" EXACT [] synonym: "neuron apoptosis" NARROW [] synonym: "neuron programmed cell death by apoptosis" EXACT [] synonym: "neuronal cell apoptosis" EXACT [] synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] synonym: "programmed cell death of neurons by apoptosis" EXACT [] synonym: "programmed cell death, neuronal cells" EXACT [] synonym: "programmed cell death, neurons" EXACT [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051321 ! regulates meiotic cell cycle relationship: RO:0002211 GO:0051321 ! regulates meiotic cell cycle [Term] id: GO:0051446 name: positive regulation of meiotic cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "activation of progression through meiotic cell cycle" NARROW [] synonym: "positive regulation of meiotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through meiotic cell cycle" NARROW [] synonym: "up regulation of progression through meiotic cell cycle" EXACT [] synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] synonym: "upregulation of progression through meiotic cell cycle" EXACT [] is_a: GO:0045787 ! positive regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle relationship: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle relationship: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle [Term] id: GO:0051450 name: myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000056 ! acts on population of myoblast relationship: RO:0012003 CL:0000056 ! acts on population of myoblast [Term] id: GO:0051451 name: myoblast migration namespace: biological_process def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000056 ! results in movement of myoblast relationship: RO:0002565 CL:0000056 ! results in movement of myoblast [Term] id: GO:0051457 name: maintenance of protein location in nucleus namespace: biological_process def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] synonym: "maintenance of nuclear protein localization" EXACT [] synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of protein location in cell nucleus" EXACT [] synonym: "nuclear protein retention" NARROW [] synonym: "nuclear protein sequestering" NARROW [] synonym: "nuclear protein sequestration" NARROW [] synonym: "protein retention in nucleus" NARROW [] synonym: "protein sequestration in nucleus" NARROW [] synonym: "protein storage in nucleus" NARROW [] synonym: "protein-nuclear retention" NARROW [] synonym: "sequestration of protein in nucleus" NARROW [] synonym: "storage of protein in nucleus" NARROW [] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005634 ! occurs in nucleus relationship: BFO:0000050 GO:0034504 ! part of protein localization to nucleus relationship: BFO:0000066 GO:0005634 ! occurs in nucleus relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: GO:0051458 name: corticotropin secretion namespace: biological_process def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [GOC:cjm, PMID:11027914] synonym: "ACTH secretion" EXACT [] synonym: "adrenocorticotropic hormone secretion" EXACT [] synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb] synonym: "adrenotropic hormone secretion" EXACT [] synonym: "adrenotropin secretion" EXACT [] synonym: "corticotropic hormone secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion is_a: GO:0060986 ! endocrine hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:3892 ! has primary input relationship: RO:0004009 CHEBI:3892 ! has primary input [Term] id: GO:0051459 name: regulation of corticotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph] synonym: "regulation of ACTH secretion" EXACT [] synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph] synonym: "regulation of adrenocorticotropin secretion" EXACT [] synonym: "regulation of adrenotropin hormone secretion" EXACT [] synonym: "regulation of adrenotropin secretion" EXACT [] synonym: "regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051458 ! regulates corticotropin secretion relationship: RO:0002211 GO:0051458 ! regulates corticotropin secretion [Term] id: GO:0051460 name: negative regulation of corticotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai] synonym: "down regulation of adrenocorticotropin secretion" EXACT [] synonym: "down-regulation of adrenocorticotropin secretion" EXACT [] synonym: "downregulation of adrenocorticotropin secretion" EXACT [] synonym: "inhibition of adrenocorticotropin secretion" NARROW [] synonym: "negative regulation of ACTH secretion" EXACT [] synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] synonym: "negative regulation of adrenotropin secretion" EXACT [] synonym: "negative regulation of corticotropic hormone secretion" EXACT [] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051459 ! regulation of corticotropin secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051458 ! negatively regulates corticotropin secretion relationship: RO:0002212 GO:0051458 ! negatively regulates corticotropin secretion [Term] id: GO:0051461 name: positive regulation of corticotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai] synonym: "activation of adrenocorticotropin secretion" NARROW [] synonym: "positive regulation of ACTH secretion" EXACT [] synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] synonym: "positive regulation of adrenotropin secretion" EXACT [] synonym: "positive regulation of corticotropic hormone secretion" EXACT [] synonym: "stimulation of adrenocorticotropin secretion" NARROW [] synonym: "up regulation of adrenocorticotropin secretion" EXACT [] synonym: "up-regulation of adrenocorticotropin secretion" EXACT [] synonym: "upregulation of adrenocorticotropin secretion" EXACT [] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051459 ! regulation of corticotropin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051458 ! positively regulates corticotropin secretion relationship: RO:0002213 GO:0051458 ! positively regulates corticotropin secretion [Term] id: GO:0051469 name: vesicle fusion with vacuole namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] is_a: GO:0006906 ! vesicle fusion is_a: GO:0097576 ! vacuole fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle [Term] id: GO:0051493 name: regulation of cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007010 ! regulates cytoskeleton organization relationship: RO:0002211 GO:0007010 ! regulates cytoskeleton organization [Term] id: GO:0051494 name: negative regulation of cytoskeleton organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "down regulation of cytoskeleton organization" EXACT [] synonym: "down-regulation of cytoskeleton organization" EXACT [] synonym: "downregulation of cytoskeleton organization" EXACT [] synonym: "inhibition of cytoskeleton organization" NARROW [] synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization relationship: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization [Term] id: GO:0051495 name: positive regulation of cytoskeleton organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] synonym: "activation of cytoskeleton organization" NARROW [] synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cytoskeleton organization" NARROW [] synonym: "up regulation of cytoskeleton organization" EXACT [] synonym: "up-regulation of cytoskeleton organization" EXACT [] synonym: "upregulation of cytoskeleton organization" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization relationship: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization [Term] id: GO:0051588 name: regulation of neurotransmitter transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006836 ! regulates neurotransmitter transport relationship: RO:0002211 GO:0006836 ! regulates neurotransmitter transport [Term] id: GO:0051589 name: negative regulation of neurotransmitter transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of neurotransmitter transport" EXACT [] synonym: "down-regulation of neurotransmitter transport" EXACT [] synonym: "downregulation of neurotransmitter transport" EXACT [] synonym: "inhibition of neurotransmitter transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport relationship: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport [Term] id: GO:0051590 name: positive regulation of neurotransmitter transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of neurotransmitter transport" NARROW [] synonym: "stimulation of neurotransmitter transport" NARROW [] synonym: "up regulation of neurotransmitter transport" EXACT [] synonym: "up-regulation of neurotransmitter transport" EXACT [] synonym: "upregulation of neurotransmitter transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport relationship: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051620 name: norepinephrine uptake namespace: biological_process def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "levarterenol reuptake" EXACT [] synonym: "levarterenol uptake" EXACT [] synonym: "noradrenaline reuptake" EXACT [] synonym: "noradrenaline uptake" EXACT [] synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "norepinephrine reuptake" EXACT [] is_a: GO:0015874 ! norepinephrine transport is_a: GO:0090493 ! catecholamine uptake intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:72587 ! has primary input [Term] id: GO:0051621 name: regulation of norepinephrine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] synonym: "regulation of levarterenol uptake" EXACT [] synonym: "regulation of noradrenaline uptake" EXACT [] synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051620 ! regulates norepinephrine uptake relationship: RO:0002211 GO:0051620 ! regulates norepinephrine uptake [Term] id: GO:0051622 name: negative regulation of norepinephrine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "down regulation of norepinephrine uptake" EXACT [] synonym: "down-regulation of norepinephrine uptake" EXACT [] synonym: "downregulation of norepinephrine uptake" EXACT [] synonym: "negative regulation of levarterenol uptake" EXACT [] synonym: "negative regulation of noradrenaline uptake" EXACT [] synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake relationship: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake [Term] id: GO:0051623 name: positive regulation of norepinephrine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] synonym: "activation of norepinephrine uptake" NARROW [] synonym: "positive regulation of levarterenol uptake" EXACT [] synonym: "positive regulation of noradrenaline uptake" EXACT [] synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of norepinephrine uptake" NARROW [] synonym: "up regulation of norepinephrine uptake" EXACT [] synonym: "up-regulation of norepinephrine uptake" EXACT [] synonym: "upregulation of norepinephrine uptake" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051621 ! regulation of norepinephrine uptake intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake relationship: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake [Term] id: GO:0051630 name: acetylcholine uptake namespace: biological_process def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0015870 ! acetylcholine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure [Term] id: GO:0051631 name: regulation of acetylcholine uptake namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051630 ! regulates acetylcholine uptake relationship: RO:0002211 GO:0051630 ! regulates acetylcholine uptake [Term] id: GO:0051632 name: negative regulation of acetylcholine uptake namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "down regulation of acetylcholine uptake" EXACT [] synonym: "down-regulation of acetylcholine uptake" EXACT [] synonym: "downregulation of acetylcholine uptake" EXACT [] synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051953 ! negative regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake relationship: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake [Term] id: GO:0051633 name: positive regulation of acetylcholine uptake namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] synonym: "activation of acetylcholine uptake" NARROW [] synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of acetylcholine uptake" NARROW [] synonym: "up regulation of acetylcholine uptake" EXACT [] synonym: "up-regulation of acetylcholine uptake" EXACT [] synonym: "upregulation of acetylcholine uptake" EXACT [] is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051954 ! positive regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake relationship: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0043226 ! has primary input organelle relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0004009 GO:0043226 ! has primary input organelle [Term] id: GO:0051641 name: cellular localization namespace: biological_process alt_id: GO:1902580 def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] synonym: "single-organism cellular localization" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:0051644 name: plastid localization namespace: biological_process def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of plastid localization" EXACT [] synonym: "plastid localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0009536 ! has primary input plastid relationship: RO:0004009 GO:0009536 ! has primary input plastid [Term] id: GO:0051645 name: Golgi localization namespace: biological_process def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of Golgi localization" EXACT [] synonym: "Golgi apparatus localization" EXACT [] synonym: "Golgi body localization" EXACT [] synonym: "Golgi localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus relationship: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051646 name: mitochondrion localization namespace: biological_process def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of mitochondria localization" EXACT [] synonym: "establishment and maintenance of mitochondrion localization" EXACT [] synonym: "localization of mitochondria" EXACT [] synonym: "localization of mitochondrion" EXACT [] synonym: "mitochondria localization" EXACT [] synonym: "mitochondrial localization" EXACT [] synonym: "mitochondrion localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus relationship: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0051648 name: vesicle localization namespace: biological_process def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cytoplasmic vesicle localization" EXACT [] synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle relationship: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000050 GO:0051641 ! part of cellular localization relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051651 name: maintenance of location in cell namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] synonym: "cellular retention" NARROW [] synonym: "cellular sequestering" NARROW [] synonym: "cellular storage" NARROW [] synonym: "intracellular retention" NARROW [] synonym: "intracellular sequestering" NARROW [] synonym: "intracellular storage" NARROW [] synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of intracellular localization" NARROW [] synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of localization within cell" NARROW [] synonym: "retention within cell" NARROW [] synonym: "sequestering within cell" NARROW [] synonym: "storage within cell" NARROW [] is_a: GO:0009987 ! cellular process is_a: GO:0051235 ! maintenance of location intersection_of: GO:0051235 ! maintenance of location intersection_of: BFO:0000066 CL:0000000 ! occurs in cell relationship: BFO:0000050 GO:0051641 ! part of cellular localization relationship: BFO:0000066 CL:0000000 ! occurs in cell [Term] id: GO:0051654 name: establishment of mitochondrion localization namespace: biological_process def: "The directed movement of the mitochondrion to a specific location." [GOC:ai] synonym: "establishment of mitochondria localization" EXACT [] synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah] synonym: "mitochondria positioning" EXACT [] synonym: "mitochondrial migration" EXACT [] synonym: "mitochondrion positioning" EXACT [] is_a: GO:0051646 ! mitochondrion localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0051655 name: maintenance of vesicle location namespace: biological_process def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051648 ! vesicle localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0043226 ! has primary input organelle [Term] id: GO:0051657 name: maintenance of organelle location namespace: biological_process def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051651 ! maintenance of location in cell relationship: BFO:0000050 GO:0051640 ! part of organelle localization [Term] id: GO:0051658 name: maintenance of nucleus location namespace: biological_process def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of cell nucleus location" EXACT [] synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051647 ! nucleus localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus [Term] id: GO:0051659 name: maintenance of mitochondrion location namespace: biological_process def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of mitochondria localization" EXACT [] synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051646 ! mitochondrion localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0051667 name: establishment of plastid localization namespace: biological_process def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai] synonym: "establishment of plastid localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0009536 ! has primary input plastid [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane relationship: RO:0002339 GO:0016020 ! has target end location membrane [Term] id: GO:0051674 name: localization of cell namespace: biological_process def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] synonym: "cell localization" EXACT [] synonym: "establishment and maintenance of cell localization" EXACT [] synonym: "establishment and maintenance of localization of cell" EXACT [] synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 CL:0000000 ! has primary input cell relationship: RO:0004009 CL:0000000 ! has primary input cell [Term] id: GO:0051683 name: establishment of Golgi localization namespace: biological_process def: "The directed movement of the Golgi to a specific location." [GOC:ai] synonym: "establishment of Golgi apparatus localization" EXACT [] synonym: "establishment of Golgi body localization" EXACT [] synonym: "establishment of Golgi localisation" EXACT [GOC:mah] is_a: GO:0051645 ! Golgi localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051684 name: maintenance of Golgi location namespace: biological_process def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of Golgi apparatus localization" EXACT [] synonym: "maintenance of Golgi body localization" EXACT [] synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051645 ! Golgi localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus [Term] id: GO:0051688 name: maintenance of plastid location namespace: biological_process def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051644 ! plastid localization is_a: GO:0051657 ! maintenance of organelle location intersection_of: GO:0051651 ! maintenance of location in cell intersection_of: RO:0004009 GO:0009536 ! has primary input plastid [Term] id: GO:0051701 name: biological process involved in interaction with host namespace: biological_process alt_id: GO:0044112 alt_id: GO:0044116 alt_id: GO:0044117 alt_id: GO:0044119 alt_id: GO:0044121 alt_id: GO:0044123 alt_id: GO:0044125 def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] synonym: "growth of symbiont in host" NARROW [] synonym: "growth of symbiont in host cell" NARROW [] synonym: "growth of symbiont in host organelle" NARROW [] synonym: "growth of symbiont in host vacuole" NARROW [] synonym: "interaction with host" EXACT [] xref: Reactome:R-HSA-9635486 "Infection with Mycobacterium tuberculosis" xref: Reactome:R-HSA-9658195 "Leishmania infection" is_a: GO:0044403 ! biological process involved in symbiotic interaction [Term] id: GO:0051704 name: multi-organism process def: "A biological process which involves another organism of the same or different species." [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051707 name: response to other organism namespace: biological_process alt_id: GO:0009613 alt_id: GO:0042828 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] is_a: GO:0043207 ! response to external biotic stimulus is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: Reactome:R-HSA-8953897 "Cellular responses to stimuli" is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 alt_id: GO:0007050 alt_id: GO:0071156 alt_id: GO:0071157 alt_id: GO:0071158 alt_id: GO:0071850 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah] synonym: "cell cycle arrest" NARROW [] synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "mitotic cell cycle arrest" NARROW [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "negative regulation of cell cycle arrest" NARROW [] synonym: "positive regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle arrest" NARROW [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] xref: Reactome:R-HSA-156711 "Polo-like kinase mediated events" xref: Reactome:R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007049 ! regulates cell cycle relationship: RO:0002211 GO:0007049 ! regulates cell cycle [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051301 ! positively regulates cell division relationship: RO:0002213 GO:0051301 ! positively regulates cell division [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051301 ! negatively regulates cell division relationship: RO:0002212 GO:0051301 ! negatively regulates cell division [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000280 ! regulates nuclear division relationship: RO:0002211 GO:0000280 ! regulates nuclear division [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000280 ! negatively regulates nuclear division relationship: RO:0002212 GO:0000280 ! negatively regulates nuclear division [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000280 ! positively regulates nuclear division relationship: RO:0002213 GO:0000280 ! positively regulates nuclear division [Term] id: GO:0051875 name: pigment granule localization namespace: biological_process def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule relationship: BFO:0000050 GO:0033059 ! part of cellular pigmentation relationship: RO:0004009 GO:0048770 ! has primary input pigment granule [Term] id: GO:0051890 name: regulation of cardioblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] is_a: GO:1905207 ! regulation of cardiocyte differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010002 ! regulates cardioblast differentiation relationship: RO:0002211 GO:0010002 ! regulates cardioblast differentiation [Term] id: GO:0051891 name: positive regulation of cardioblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "activation of cardioblast differentiation" NARROW [] synonym: "stimulation of cardioblast differentiation" NARROW [] synonym: "up regulation of cardioblast differentiation" EXACT [] synonym: "up-regulation of cardioblast differentiation" EXACT [] synonym: "upregulation of cardioblast differentiation" EXACT [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation relationship: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation [Term] id: GO:0051892 name: negative regulation of cardioblast differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] synonym: "down regulation of cardioblast differentiation" EXACT [] synonym: "down-regulation of cardioblast differentiation" EXACT [] synonym: "downregulation of cardioblast differentiation" EXACT [] synonym: "inhibition of cardioblast differentiation" NARROW [] is_a: GO:0051890 ! regulation of cardioblast differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation relationship: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation [Term] id: GO:0051904 name: pigment granule transport namespace: biological_process def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "pigment granule translocation" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0051875 ! pigment granule localization is_a: GO:0051905 ! establishment of pigment granule localization intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule [Term] id: GO:0051905 name: establishment of pigment granule localization namespace: biological_process def: "The directed movement of a pigment granule to a specific location." [GOC:ai] synonym: "establishment of pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: BFO:0000050 GO:0051875 ! part of pigment granule localization [Term] id: GO:0051930 name: regulation of sensory perception of pain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0051931 ! regulation of sensory perception intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019233 ! regulates sensory perception of pain relationship: RO:0002211 GO:0019233 ! regulates sensory perception of pain [Term] id: GO:0051931 name: regulation of sensory perception namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007600 ! regulates sensory perception relationship: RO:0002211 GO:0007600 ! regulates sensory perception [Term] id: GO:0051932 name: synaptic transmission, GABAergic namespace: biological_process def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, ISBN:0126603030] synonym: "GABAergic synaptic transmission" EXACT [] synonym: "synaptic transmission, GABA mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission intersection_of: GO:0007268 ! chemical synaptic transmission intersection_of: RO:0000057 CHEBI:59888 ! has participant intersection_of: RO:0000057 CL:0000617 ! has participant GABAergic neuron relationship: RO:0000057 CHEBI:59888 ! has participant relationship: RO:0000057 CL:0000617 ! has participant GABAergic neuron [Term] id: GO:0051937 name: catecholamine transport namespace: biological_process def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732] is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input [Term] id: GO:0051938 name: L-glutamate import namespace: biological_process def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015807 ! L-amino acid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0051939 name: gamma-aminobutyric acid import namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai] synonym: "4-aminobutyrate import" EXACT [] synonym: "GABA import" EXACT [] synonym: "gamma-aminobutyrate import" EXACT [] synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015812 ! gamma-aminobutyric acid transport intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0004009 CHEBI:59888 ! has primary input [Term] id: GO:0051952 name: regulation of amine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015837 ! regulates amine transport relationship: RO:0002211 GO:0015837 ! regulates amine transport [Term] id: GO:0051953 name: negative regulation of amine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amine transport" EXACT [] synonym: "down-regulation of amine transport" EXACT [] synonym: "downregulation of amine transport" EXACT [] synonym: "inhibition of amine transport" NARROW [] is_a: GO:0051051 ! negative regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0015837 ! negatively regulates amine transport relationship: RO:0002212 GO:0015837 ! negatively regulates amine transport [Term] id: GO:0051954 name: positive regulation of amine transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amine transport" NARROW [] synonym: "stimulation of amine transport" NARROW [] synonym: "up regulation of amine transport" EXACT [] synonym: "up-regulation of amine transport" EXACT [] synonym: "upregulation of amine transport" EXACT [] is_a: GO:0051050 ! positive regulation of transport is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0015837 ! positively regulates amine transport relationship: RO:0002213 GO:0015837 ! positively regulates amine transport [Term] id: GO:0051955 name: regulation of amino acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0051952 ! regulation of amine transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006865 ! regulates amino acid transport relationship: RO:0002211 GO:0006865 ! regulates amino acid transport [Term] id: GO:0051956 name: negative regulation of amino acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "down regulation of amino acid transport" EXACT [] synonym: "down-regulation of amino acid transport" EXACT [] synonym: "downregulation of amino acid transport" EXACT [] synonym: "inhibition of amino acid transport" NARROW [] synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006865 ! negatively regulates amino acid transport relationship: RO:0002212 GO:0006865 ! negatively regulates amino acid transport [Term] id: GO:0051957 name: positive regulation of amino acid transport namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "activation of amino acid transport" NARROW [] synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] synonym: "stimulation of amino acid transport" NARROW [] synonym: "up regulation of amino acid transport" EXACT [] synonym: "up-regulation of amino acid transport" EXACT [] synonym: "upregulation of amino acid transport" EXACT [] is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006865 ! positively regulates amino acid transport relationship: RO:0002213 GO:0006865 ! positively regulates amino acid transport [Term] id: GO:0051960 name: regulation of nervous system development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007399 ! regulates nervous system development relationship: RO:0002211 GO:0007399 ! regulates nervous system development [Term] id: GO:0051961 name: negative regulation of nervous system development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "down regulation of nervous system development" EXACT [] synonym: "down-regulation of nervous system development" EXACT [] synonym: "downregulation of nervous system development" EXACT [] synonym: "inhibition of nervous system development" NARROW [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007399 ! negatively regulates nervous system development relationship: RO:0002212 GO:0007399 ! negatively regulates nervous system development [Term] id: GO:0051962 name: positive regulation of nervous system development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] synonym: "activation of nervous system development" NARROW [] synonym: "stimulation of nervous system development" NARROW [] synonym: "up regulation of nervous system development" EXACT [] synonym: "up-regulation of nervous system development" EXACT [] synonym: "upregulation of nervous system development" EXACT [] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0051960 ! regulation of nervous system development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007399 ! positively regulates nervous system development relationship: RO:0002213 GO:0007399 ! positively regulates nervous system development [Term] id: GO:0051963 name: regulation of synapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] subset: goslim_synapse synonym: "regulation of synapse biogenesis" EXACT [] synonym: "regulation of synaptogenesis" EXACT [] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007416 ! regulates synapse assembly relationship: RO:0002211 GO:0007416 ! regulates synapse assembly [Term] id: GO:0051964 name: negative regulation of synapse assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "down regulation of synapse assembly" EXACT [] synonym: "down-regulation of synapse assembly" EXACT [] synonym: "downregulation of synapse assembly" EXACT [] synonym: "inhibition of synapse assembly" NARROW [] synonym: "negative regulation of synapse biogenesis" EXACT [] synonym: "negative regulation of synaptogenesis" EXACT [] is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007416 ! negatively regulates synapse assembly relationship: RO:0002212 GO:0007416 ! negatively regulates synapse assembly [Term] id: GO:0051965 name: positive regulation of synapse assembly namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] synonym: "activation of synapse assembly" NARROW [] synonym: "positive regulation of synapse biogenesis" EXACT [] synonym: "positive regulation of synaptogenesis" EXACT [] synonym: "stimulation of synapse assembly" NARROW [] synonym: "up regulation of synapse assembly" EXACT [] synonym: "up-regulation of synapse assembly" EXACT [] synonym: "upregulation of synapse assembly" EXACT [] is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1901890 ! positive regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007416 ! positively regulates synapse assembly relationship: RO:0002213 GO:0007416 ! positively regulates synapse assembly [Term] id: GO:0051966 name: regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035249 ! regulates synaptic transmission, glutamatergic relationship: RO:0002211 GO:0035249 ! regulates synaptic transmission, glutamatergic [Term] id: GO:0051967 name: negative regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "down regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "downregulation of synaptic transmission, glutamatergic" EXACT [] synonym: "inhibition of synaptic transmission, glutamatergic" NARROW [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035249 ! negatively regulates synaptic transmission, glutamatergic relationship: RO:0002212 GO:0035249 ! negatively regulates synaptic transmission, glutamatergic [Term] id: GO:0051968 name: positive regulation of synaptic transmission, glutamatergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] synonym: "activation of synaptic transmission, glutamatergic" NARROW [] synonym: "stimulation of synaptic transmission, glutamatergic" NARROW [] synonym: "up regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT [] synonym: "upregulation of synaptic transmission, glutamatergic" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035249 ! positively regulates synaptic transmission, glutamatergic relationship: RO:0002213 GO:0035249 ! positively regulates synaptic transmission, glutamatergic [Term] id: GO:0051969 name: regulation of transmission of nerve impulse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0031644 ! regulation of nervous system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse relationship: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse [Term] id: GO:0051970 name: negative regulation of transmission of nerve impulse namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "down regulation of transmission of nerve impulse" EXACT [] synonym: "down-regulation of transmission of nerve impulse" EXACT [] synonym: "downregulation of transmission of nerve impulse" EXACT [] synonym: "inhibition of transmission of nerve impulse" NARROW [] synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse relationship: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse [Term] id: GO:0051971 name: positive regulation of transmission of nerve impulse namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] synonym: "activation of transmission of nerve impulse" NARROW [] synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph] synonym: "stimulation of transmission of nerve impulse" NARROW [] synonym: "up regulation of transmission of nerve impulse" EXACT [] synonym: "up-regulation of transmission of nerve impulse" EXACT [] synonym: "upregulation of transmission of nerve impulse" EXACT [] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051969 ! regulation of transmission of nerve impulse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse relationship: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007059 ! regulates chromosome segregation relationship: RO:0002211 GO:0007059 ! regulates chromosome segregation [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007059 ! positively regulates chromosome segregation relationship: RO:0002213 GO:0007059 ! positively regulates chromosome segregation [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation relationship: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation [Term] id: GO:0052372 name: modulation by symbiont of entry into host namespace: biological_process alt_id: GO:0052371 def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED [] synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "regulation by organism of entry into other organism involved in symbiotic interaction" RELATED [] is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044409 ! regulates entry into host relationship: RO:0002211 GO:0044409 ! regulates entry into host [Term] id: GO:0052547 name: regulation of peptidase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai] subset: gocheck_obsoletion_candidate synonym: "peptidase regulator activity" RELATED [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008233 ! regulates peptidase activity relationship: RO:0002211 GO:0008233 ! regulates peptidase activity [Term] id: GO:0055001 name: muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] synonym: "muscle fiber development" EXACT [] synonym: "muscle fibre development" EXACT [] synonym: "myofiber development" EXACT [] synonym: "myofibre development" EXACT [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000187 ! results in development of muscle cell relationship: BFO:0000050 GO:0042692 ! part of muscle cell differentiation relationship: RO:0002296 CL:0000187 ! results in development of muscle cell [Term] id: GO:0055002 name: striated muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] is_a: GO:0055001 ! muscle cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000737 ! results in development of striated muscle cell relationship: BFO:0000050 GO:0051146 ! part of striated muscle cell differentiation relationship: RO:0002296 CL:0000737 ! results in development of striated muscle cell [Term] id: GO:0055003 name: cardiac myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] synonym: "cardiac myofibril development" EXACT [] synonym: "cardiac myofibril morphogenesis" EXACT [] synonym: "heart myofibril assembly" RELATED [] is_a: GO:0030239 ! myofibril assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril relationship: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development relationship: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril [Term] id: GO:0055006 name: cardiac cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] synonym: "cardiocyte development" EXACT [GOC:dph] synonym: "heart cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0002494 ! results in development of cardiocyte relationship: BFO:0000050 GO:0035051 ! part of cardiocyte differentiation relationship: RO:0002296 CL:0002494 ! results in development of cardiocyte [Term] id: GO:0055007 name: cardiac muscle cell differentiation namespace: biological_process def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiomyocyte differentiation" EXACT [] synonym: "heart muscle cell differentiation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0051146 ! striated muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development relationship: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell [Term] id: GO:0055008 name: cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol] synonym: "heart muscle morphogenesis" EXACT [] synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development relationship: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue [Term] id: GO:0055009 name: atrial cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol] synonym: "atrial heart muscle morphogenesis" EXACT [] synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac atrium muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis relationship: BFO:0000050 GO:0003228 ! part of atrial cardiac muscle tissue development relationship: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium [Term] id: GO:0055010 name: ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol] synonym: "cardiac ventricle muscle morphogenesis" EXACT [] synonym: "ventricular heart muscle morphogenesis" EXACT [] is_a: GO:0055008 ! cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle relationship: BFO:0000050 GO:0003208 ! part of cardiac ventricle morphogenesis relationship: BFO:0000050 GO:0003229 ! part of ventricular cardiac muscle tissue development relationship: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle [Term] id: GO:0055013 name: cardiac muscle cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart] synonym: "cardiac muscle fiber development" EXACT [] synonym: "cardiac muscle fibre development" EXACT [] synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle] synonym: "heart muscle cell development" EXACT [] synonym: "heart muscle fiber development" RELATED [] is_a: GO:0055002 ! striated muscle cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell relationship: BFO:0000050 GO:0055007 ! part of cardiac muscle cell differentiation relationship: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell [Term] id: GO:0055017 name: cardiac muscle tissue growth namespace: biological_process def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] synonym: "heart muscle growth" EXACT [] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development relationship: BFO:0000050 GO:0060419 ! part of heart growth relationship: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue [Term] id: GO:0055018 name: regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "regulation of cardiac muscle fibre development" EXACT [] synonym: "regulation of heart muscle fiber development" EXACT [] is_a: GO:0060284 ! regulation of cell development is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development relationship: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development [Term] id: GO:0055019 name: negative regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "down regulation of cardiac muscle fiber development" EXACT [] synonym: "down-regulation of cardiac muscle fiber development" EXACT [] synonym: "downregulation of cardiac muscle fiber development" EXACT [] synonym: "inhibition of cardiac muscle fiber development" NARROW [] synonym: "negative regulation of cardiac muscle fibre development" EXACT [] synonym: "negative regulation of heart muscle fiber development" RELATED [] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055018 ! regulation of cardiac muscle fiber development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development relationship: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development [Term] id: GO:0055020 name: positive regulation of cardiac muscle fiber development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] synonym: "activation of cardiac muscle fiber development" NARROW [] synonym: "positive regulation of cardiac muscle fibre development" EXACT [] synonym: "positive regulation of heart muscle fiber development" EXACT [] synonym: "stimulation of cardiac muscle fiber development" NARROW [] synonym: "up regulation of cardiac muscle fiber development" EXACT [] synonym: "up-regulation of cardiac muscle fiber development" EXACT [] synonym: "upregulation of cardiac muscle fiber development" EXACT [] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0055018 ! regulation of cardiac muscle fiber development is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development relationship: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development [Term] id: GO:0055021 name: regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth relationship: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth [Term] id: GO:0055022 name: negative regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "down regulation of cardiac muscle growth" EXACT [] synonym: "down-regulation of cardiac muscle growth" EXACT [] synonym: "downregulation of cardiac muscle growth" EXACT [] synonym: "inhibition of cardiac muscle growth" NARROW [] synonym: "negative regulation of heart muscle growth" RELATED [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0061117 ! negative regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth relationship: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth [Term] id: GO:0055023 name: positive regulation of cardiac muscle tissue growth namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] synonym: "activation of cardiac muscle growth" NARROW [] synonym: "positive regulation of heart muscle growth" EXACT [] synonym: "stimulation of cardiac muscle growth" NARROW [] synonym: "up regulation of cardiac muscle growth" EXACT [] synonym: "up-regulation of cardiac muscle growth" EXACT [] synonym: "upregulation of cardiac muscle growth" EXACT [] is_a: GO:0055021 ! regulation of cardiac muscle tissue growth is_a: GO:0060421 ! positive regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth relationship: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth [Term] id: GO:0055024 name: regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "regulation of heart muscle development" EXACT [] is_a: GO:0016202 ! regulation of striated muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development relationship: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development [Term] id: GO:0055025 name: positive regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "activation of cardiac muscle development" NARROW [] synonym: "positive regulation of heart muscle development" EXACT [] synonym: "stimulation of cardiac muscle development" NARROW [] synonym: "up regulation of cardiac muscle development" EXACT [] synonym: "up-regulation of cardiac muscle development" EXACT [] synonym: "upregulation of cardiac muscle development" EXACT [] is_a: GO:0045844 ! positive regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development relationship: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development [Term] id: GO:0055026 name: negative regulation of cardiac muscle tissue development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] synonym: "down regulation of cardiac muscle development" EXACT [] synonym: "down-regulation of cardiac muscle development" EXACT [] synonym: "downregulation of cardiac muscle development" EXACT [] synonym: "inhibition of cardiac muscle development" NARROW [] synonym: "negative regulation of heart muscle development" EXACT [] is_a: GO:0045843 ! negative regulation of striated muscle tissue development is_a: GO:0055024 ! regulation of cardiac muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development relationship: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development [Term] id: GO:0055057 name: neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] synonym: "neuroblast cell division" EXACT [] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) relationship: BFO:0000050 GO:0007405 ! part of neuroblast proliferation relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0055059 name: asymmetric neuroblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0045165 ! cell fate commitment is_a: GO:0055057 ! neuroblast division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata) [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process alt_id: GO:0090662 def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_drosophila subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] xref: Reactome:R-HSA-382556 "ABC-family proteins mediated transport" xref: Reactome:R-HSA-425407 "SLC-mediated transmembrane transport" xref: Reactome:R-HSA-5223345 "Miscellaneous transport and binding events" is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: RO:0002342 GO:0016020 ! results in transport across membrane created_by: tb creation_date: 2015-10-21T13:22:47Z [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_yeast synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] xref: Reactome:R-HSA-15869 "Metabolism of nucleotides" xref: Reactome:R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins" is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0055107 name: Golgi to secretory granule transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0030141 ! has target end location secretory granule [Term] id: GO:0055108 name: Golgi to transport vesicle transport namespace: biological_process def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] is_a: GO:0046907 ! intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0030133 ! has target end location transport vesicle relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus relationship: RO:0002339 GO:0030133 ! has target end location transport vesicle [Term] id: GO:0055117 name: regulation of cardiac muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0006942 ! regulation of striated muscle contraction is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction relationship: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction [Term] id: GO:0055118 name: negative regulation of cardiac muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] is_a: GO:0045822 ! negative regulation of heart contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction relationship: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction [Term] id: GO:0055123 name: digestive system development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001007 ! results in development of digestive system relationship: RO:0002296 UBERON:0001007 ! results in development of digestive system [Term] id: GO:0060012 name: synaptic transmission, glycinergic namespace: biological_process def: "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] synonym: "glycinergic synaptic transmission" EXACT [] is_a: GO:0007268 ! chemical synaptic transmission relationship: RO:0000057 CHEBI:57305 ! has participant [Term] id: GO:0060019 name: radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph] is_a: GO:0010001 ! glial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000681 ! results in acquisition of features of radial glial cell relationship: RO:0002315 CL:0000681 ! results in acquisition of features of radial glial cell [Term] id: GO:0060020 name: Bergmann glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] is_a: GO:0048708 ! astrocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000644 ! results in acquisition of features of Bergmann glial cell relationship: RO:0002315 CL:0000644 ! results in acquisition of features of Bergmann glial cell [Term] id: GO:0060037 name: pharyngeal system development namespace: biological_process def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development relationship: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system [Term] id: GO:0060038 name: cardiac muscle cell proliferation namespace: biological_process def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571] synonym: "cardiac myocyte proliferation" EXACT [] synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] synonym: "heart muscle cell proliferation" EXACT [] is_a: GO:0014855 ! striated muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth relationship: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell [Term] id: GO:0060039 name: pericardium development namespace: biological_process def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002407 ! results in development of pericardium relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0002407 ! results in development of pericardium [Term] id: GO:0060041 name: retina development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729] synonym: "retina development in camera-style eye" EXACT [] synonym: "retinal development" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: BFO:0000050 GO:0043010 ! part of camera-type eye development intersection_of: RO:0002296 UBERON:0000966 ! results in development of retina relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0000966 ! results in development of retina [Term] id: GO:0060042 name: retina morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu] synonym: "retina morphogenesis in camera-style eye" EXACT [] synonym: "retinogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina [Term] id: GO:0060043 name: regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph] synonym: "regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation relationship: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation [Term] id: GO:0060044 name: negative regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "negative regulation of heart muscle cell proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation relationship: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation [Term] id: GO:0060045 name: positive regulation of cardiac muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] synonym: "positive regulation of heart muscle cell proliferation" RELATED [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation relationship: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation [Term] id: GO:0060047 name: heart contraction namespace: biological_process def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] synonym: "cardiac contraction" RELATED [] synonym: "heart beating" EXACT [] synonym: "hemolymph circulation" RELATED [] is_a: GO:0003015 ! heart process relationship: BFO:0000050 GO:0008015 ! part of blood circulation [Term] id: GO:0060048 name: cardiac muscle contraction namespace: biological_process def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] synonym: "heart muscle contraction" EXACT [] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue relationship: BFO:0000050 GO:0060047 ! part of heart contraction relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue [Term] id: GO:0060089 name: molecular transducer activity namespace: molecular_function def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt] subset: gocheck_do_not_annotate subset: goslim_generic subset: goslim_pir subset: goslim_prokaryote is_a: GO:0003674 ! molecular_function [Term] id: GO:0060092 name: regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060012 ! regulates synaptic transmission, glycinergic relationship: RO:0002211 GO:0060012 ! regulates synaptic transmission, glycinergic [Term] id: GO:0060093 name: negative regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "negative regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050805 ! negative regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060012 ! negatively regulates synaptic transmission, glycinergic relationship: RO:0002212 GO:0060012 ! negatively regulates synaptic transmission, glycinergic [Term] id: GO:0060094 name: positive regulation of synaptic transmission, glycinergic namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] synonym: "positive regulation of glycinergic synaptic transmission" EXACT [] is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060012 ! positively regulates synaptic transmission, glycinergic relationship: RO:0002213 GO:0060012 ! positively regulates synaptic transmission, glycinergic [Term] id: GO:0060096 name: serotonin secretion, neurotransmission namespace: biological_process def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph] synonym: "serotonin release, neurotransmission" RELATED [GOC:tb] is_a: GO:0001820 ! serotonin secretion is_a: GO:0007269 ! neurotransmitter secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0060123 name: regulation of growth hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030252 ! regulates growth hormone secretion relationship: RO:0002211 GO:0030252 ! regulates growth hormone secretion [Term] id: GO:0060124 name: positive regulation of growth hormone secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030252 ! positively regulates growth hormone secretion relationship: RO:0002213 GO:0030252 ! positively regulates growth hormone secretion [Term] id: GO:0060125 name: negative regulation of growth hormone secretion namespace: biological_process def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] is_a: GO:0060123 ! regulation of growth hormone secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030252 ! negatively regulates growth hormone secretion relationship: RO:0002212 GO:0030252 ! negatively regulates growth hormone secretion [Term] id: GO:0060126 name: somatotropin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell differentiation" EXACT [] synonym: "somatotrope differentiation" RELATED [] synonym: "somatotroph differentiation" RELATED [] synonym: "somatotrophin secreting cell differentiation" EXACT [] synonym: "somatotropic cell differentiation" RELATED [] synonym: "somatrophic cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000295 ! results in acquisition of features of somatotropin secreting cell relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000295 ! results in acquisition of features of somatotropin secreting cell [Term] id: GO:0060127 name: prolactin secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil differentiation" EXACT [] synonym: "lactotrope differentiation" EXACT [] synonym: "lactotroph differentiation" EXACT [] synonym: "lactotropic cell differentiation" EXACT [] synonym: "mammotrope differentiation" EXACT [] synonym: "mammotroph differentiation" EXACT [] synonym: "mammotrophic cell differentiation" EXACT [] synonym: "mammotropic cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000439 ! results in acquisition of features of prolactin secreting cell relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000439 ! results in acquisition of features of prolactin secreting cell [Term] id: GO:0060128 name: corticotropin hormone secreting cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT [] synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph] synonym: "corticotrope differentiation" EXACT [] synonym: "corticotroph differentiation" EXACT [] synonym: "corticotrophin hormone secreting cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000467 ! results in acquisition of features of adrenocorticotropic hormone secreting cell relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development relationship: RO:0002315 CL:0000467 ! results in acquisition of features of adrenocorticotropic hormone secreting cell [Term] id: GO:0060131 name: corticotropin hormone secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] synonym: "adrenocorticotrophic hormone secreting cell development" EXACT [] synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph] synonym: "corticotrope development" EXACT [] synonym: "corticotroph development" RELATED [] synonym: "corticotrophin hormone secreting cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000467 ! results in development of adrenocorticotropic hormone secreting cell relationship: BFO:0000050 GO:0060128 ! part of corticotropin hormone secreting cell differentiation relationship: RO:0002296 CL:0000467 ! results in development of adrenocorticotropic hormone secreting cell [Term] id: GO:0060132 name: prolactin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] synonym: "epsilon-acidophil development" EXACT [] synonym: "lactotrope development" EXACT [] synonym: "lactotroph development" EXACT [] synonym: "lactotropic cell development" EXACT [] synonym: "mammotrope development" EXACT [] synonym: "mammotroph development" EXACT [] synonym: "mammotrophic cell development" EXACT [] synonym: "mammotropic cell development" EXACT [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000439 ! results in development of prolactin secreting cell relationship: BFO:0000050 GO:0060127 ! part of prolactin secreting cell differentiation relationship: RO:0002296 CL:0000439 ! results in development of prolactin secreting cell [Term] id: GO:0060133 name: somatotropin secreting cell development namespace: biological_process def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] synonym: "growth hormone secreting cell development" EXACT [] synonym: "somatotrope development" RELATED [] synonym: "somatotroph development" RELATED [] synonym: "somatotrophin secreting cell development" EXACT [] synonym: "somatotropic cell development" EXACT [] synonym: "somatrophic cell development" RELATED [] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000295 ! results in development of somatotropin secreting cell relationship: BFO:0000050 GO:0060126 ! part of somatotropin secreting cell differentiation relationship: RO:0002296 CL:0000295 ! results in development of somatotropin secreting cell [Term] id: GO:0060136 name: embryonic process involved in female pregnancy namespace: biological_process def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph] is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0022414 ! reproductive process intersection_of: BFO:0000050 GO:0007565 ! part of female pregnancy intersection_of: BFO:0000050 GO:0009790 ! part of embryo development relationship: BFO:0000050 GO:0007565 ! part of female pregnancy relationship: BFO:0000050 GO:0009792 ! part of embryo development ending in birth or egg hatching [Term] id: GO:0060142 name: regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion relationship: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion [Term] id: GO:0060143 name: positive regulation of syncytium formation by plasma membrane fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion relationship: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion [Term] id: GO:0060170 name: ciliary membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. synonym: "cilial membrane" EXACT [] synonym: "cilium membrane" EXACT [] synonym: "flagellar membrane" NARROW [] synonym: "flagellum membrane" NARROW [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005929 ! bounding layer of cilium relationship: RO:0002007 GO:0005929 ! bounding layer of cilium [Term] id: GO:0060173 name: limb development namespace: biological_process def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] synonym: "limb bud development" NARROW [GOC:dph] synonym: "paired limb/fin development" EXACT [] xref: Wikipedia:Limb_development is_a: GO:0048736 ! appendage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin relationship: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin [Term] id: GO:0060214 name: endocardium formation namespace: biological_process def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002165 ! results in formation of endocardium relationship: BFO:0000050 GO:0003160 ! part of endocardium morphogenesis relationship: RO:0002297 UBERON:0002165 ! results in formation of endocardium [Term] id: GO:0060218 name: hematopoietic stem cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] synonym: "haematopoietic stem cell differentiation" EXACT [] synonym: "haemopoietic stem cell differentiation" EXACT [] synonym: "hemopoietic stem cell differentiation" EXACT [] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation is_a: GO:0048863 ! stem cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell relationship: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell [Term] id: GO:0060219 name: camera-type eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell relationship: BFO:0000050 GO:0003407 ! part of neural retina development relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye relationship: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell [Term] id: GO:0060221 name: retinal rod cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell relationship: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell [Term] id: GO:0060231 name: mesenchymal to epithelial transition namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell intersection_of: RO:0004009 CL:0008019 ! has primary input mesenchymal cell relationship: RO:0004009 CL:0008019 ! has primary input mesenchymal cell [Term] id: GO:0060249 name: anatomical structure homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] synonym: "anatomical structure maintenance" EXACT [GOC:dph] is_a: GO:0048871 ! multicellular organismal-level homeostasis [Term] id: GO:0060251 name: regulation of glial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014009 ! regulates glial cell proliferation relationship: RO:0002211 GO:0014009 ! regulates glial cell proliferation [Term] id: GO:0060252 name: positive regulation of glial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation relationship: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation [Term] id: GO:0060253 name: negative regulation of glial cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0060251 ! regulation of glial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation relationship: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process relationship: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process [Term] id: GO:0060263 name: regulation of respiratory burst namespace: biological_process def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045730 ! regulates respiratory burst relationship: RO:0002211 GO:0045730 ! regulates respiratory burst [Term] id: GO:0060271 name: cilium assembly namespace: biological_process def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliogenesis" EXACT [] synonym: "cilium biogenesis" RELATED [GOC:mah] synonym: "cilium formation" EXACT [] synonym: "cilium morphogenesis" RELATED [] synonym: "cilium organization" RELATED [GOC:dph] synonym: "microtubule-based flagellum assembly" EXACT [] xref: Reactome:R-HSA-5617833 "Cilium Assembly" is_a: GO:0044782 ! cilium organization is_a: GO:0070925 ! organelle assembly is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005929 ! results in assembly of cilium relationship: BFO:0000051 GO:0035082 ! has part axoneme assembly relationship: BFO:0000051 GO:0035735 ! has part intraciliary transport involved in cilium assembly relationship: BFO:0000051 GO:0061512 ! has part protein localization to cilium relationship: BFO:0000051 GO:0097712 ! has part vesicle targeting, trans-Golgi to periciliary membrane compartment relationship: BFO:0000051 GO:1905349 ! has part ciliary transition zone assembly relationship: RO:0002224 GO:0097711 ! starts with ciliary basal body-plasma membrane docking relationship: RO:0002588 GO:0005929 ! results in assembly of cilium [Term] id: GO:0060281 name: regulation of oocyte development namespace: biological_process def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] is_a: GO:1905879 ! regulation of oogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048599 ! regulates oocyte development relationship: RO:0002211 GO:0048599 ! regulates oocyte development [Term] id: GO:0060282 name: positive regulation of oocyte development namespace: biological_process def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048599 ! positively regulates oocyte development relationship: RO:0002213 GO:0048599 ! positively regulates oocyte development [Term] id: GO:0060283 name: negative regulation of oocyte development namespace: biological_process def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048599 ! negatively regulates oocyte development relationship: RO:0002212 GO:0048599 ! negatively regulates oocyte development [Term] id: GO:0060284 name: regulation of cell development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048468 ! regulates cell development relationship: RO:0002211 GO:0048468 ! regulates cell development [Term] id: GO:0060285 name: cilium-dependent cell motility namespace: biological_process def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. synonym: "ciliary cell motility" RELATED [] synonym: "cilium cell motility" EXACT [] synonym: "microtubule-based flagellar cell motility" EXACT [] is_a: GO:0001539 ! cilium or flagellum-dependent cell motility relationship: BFO:0000051 GO:0003341 ! has part cilium movement [Term] id: GO:0060294 name: cilium movement involved in cell motility namespace: biological_process def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement intersection_of: GO:0003341 ! cilium movement intersection_of: BFO:0000050 GO:0048870 ! part of cell motility relationship: BFO:0000050 GO:0060285 ! part of cilium-dependent cell motility [Term] id: GO:0060295 name: regulation of cilium movement involved in cell motility namespace: biological_process def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:1902019 ! regulation of cilium-dependent cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060294 ! regulates cilium movement involved in cell motility relationship: RO:0002211 GO:0060294 ! regulates cilium movement involved in cell motility [Term] id: GO:0060297 name: regulation of sarcomere organization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045214 ! regulates sarcomere organization relationship: RO:0002211 GO:0045214 ! regulates sarcomere organization [Term] id: GO:0060298 name: positive regulation of sarcomere organization namespace: biological_process def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045214 ! positively regulates sarcomere organization relationship: RO:0002213 GO:0045214 ! positively regulates sarcomere organization [Term] id: GO:0060299 name: negative regulation of sarcomere organization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:0060297 ! regulation of sarcomere organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization relationship: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization [Term] id: GO:0060322 name: head development namespace: biological_process def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000033 ! results in development of head relationship: RO:0002296 UBERON:0000033 ! results in development of head [Term] id: GO:0060323 name: head morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000033 ! results in morphogenesis of head relationship: BFO:0000050 GO:0010171 ! part of body morphogenesis relationship: BFO:0000050 GO:0060322 ! part of head development relationship: RO:0002298 UBERON:0000033 ! results in morphogenesis of head [Term] id: GO:0060324 name: face development namespace: biological_process def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001456 ! results in development of face relationship: BFO:0000050 GO:0060322 ! part of head development relationship: RO:0002296 UBERON:0001456 ! results in development of face [Term] id: GO:0060325 name: face morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001456 ! results in morphogenesis of face relationship: BFO:0000050 GO:0060323 ! part of head morphogenesis relationship: BFO:0000050 GO:0060324 ! part of face development relationship: RO:0002298 UBERON:0001456 ! results in morphogenesis of face [Term] id: GO:0060326 name: cell chemotaxis namespace: biological_process def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] xref: Reactome:R-HSA-9664424 "Cell recruitment (pro-inflammatory response)" is_a: GO:0006935 ! chemotaxis is_a: GO:0016477 ! cell migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000000 ! results in movement of cell relationship: BFO:0000050 GO:0070887 ! part of cellular response to chemical stimulus relationship: RO:0002565 CL:0000000 ! results in movement of cell [Term] id: GO:0060341 name: regulation of cellular localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] synonym: "regulation of cellular localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051641 ! regulates cellular localization relationship: RO:0002211 GO:0051641 ! regulates cellular localization [Term] id: GO:0060348 name: bone development namespace: biological_process def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048513 ! animal organ development intersection_of: RO:0002296 UBERON:0001474 ! results in development of bone element relationship: BFO:0000050 GO:0001501 ! part of skeletal system development relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0001474 ! results in development of bone element [Term] id: GO:0060349 name: bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element relationship: BFO:0000050 GO:0048705 ! part of skeletal system morphogenesis relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element [Term] id: GO:0060350 name: endochondral bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone relationship: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone [Term] id: GO:0060351 name: cartilage development involved in endochondral bone morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0051216 ! cartilage development intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis [Term] id: GO:0060363 name: cranial suture morphogenesis namespace: biological_process def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl] is_a: GO:0097094 ! craniofacial suture morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003685 ! results in morphogenesis of cranial suture relationship: RO:0002298 UBERON:0003685 ! results in morphogenesis of cranial suture [Term] id: GO:0060379 name: cardiac muscle cell myoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb] synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation is_a: GO:0045445 ! myoblast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast relationship: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast [Term] id: GO:0060404 name: axonemal microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010938 ! cytoplasmic microtubule depolymerization is_a: GO:0061523 ! cilium disassembly intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: BFO:0000066 GO:0005930 ! occurs in axoneme relationship: BFO:0000066 GO:0005930 ! occurs in axoneme [Term] id: GO:0060408 name: regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033238 ! regulation of amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process relationship: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process [Term] id: GO:0060409 name: positive regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033240 ! positive regulation of amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process relationship: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process [Term] id: GO:0060410 name: negative regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0033239 ! negative regulation of amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008291 ! negatively regulates acetylcholine metabolic process relationship: RO:0002212 GO:0008291 ! negatively regulates acetylcholine metabolic process [Term] id: GO:0060411 name: cardiac septum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] synonym: "heart septum morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis relationship: BFO:0000050 GO:0003279 ! part of cardiac septum development relationship: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum [Term] id: GO:0060412 name: ventricular septum morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph] synonym: "interventricular septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum relationship: BFO:0000050 GO:0003281 ! part of ventricular septum development relationship: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum [Term] id: GO:0060413 name: atrial septum morphogenesis namespace: biological_process def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart] synonym: "interatrial septum morphogenesis" EXACT [GOC:dph] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis relationship: BFO:0000050 GO:0003283 ! part of atrial septum development relationship: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum [Term] id: GO:0060414 name: aorta smooth muscle tissue morphogenesis namespace: biological_process def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis relationship: BFO:0000050 GO:0048745 ! part of smooth muscle tissue development relationship: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue [Term] id: GO:0060415 name: muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0048729 ! tissue morphogenesis intersection_of: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue relationship: BFO:0000050 GO:0048644 ! part of muscle organ morphogenesis relationship: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue [Term] id: GO:0060419 name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0000948 ! results in growth of heart relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002343 UBERON:0000948 ! results in growth of heart [Term] id: GO:0060420 name: regulation of heart growth namespace: biological_process def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0046620 ! regulation of organ growth is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060419 ! regulates heart growth relationship: RO:0002211 GO:0060419 ! regulates heart growth [Term] id: GO:0060421 name: positive regulation of heart growth namespace: biological_process def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0046622 ! positive regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060419 ! positively regulates heart growth relationship: RO:0002213 GO:0060419 ! positively regulates heart growth [Term] id: GO:0060425 name: lung morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung [Term] id: GO:0060426 name: lung vasculature development namespace: biological_process def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000102 ! results in development of lung vasculature relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000102 ! results in development of lung vasculature [Term] id: GO:0060427 name: lung connective tissue development namespace: biological_process def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary connective tissue development" EXACT [] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue [Term] id: GO:0060428 name: lung epithelium development namespace: biological_process def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000115 ! results in development of lung epithelium relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002296 UBERON:0000115 ! results in development of lung epithelium [Term] id: GO:0060429 name: epithelium development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] subset: goslim_drosophila is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000483 ! results in development of epithelium relationship: RO:0002296 UBERON:0000483 ! results in development of epithelium [Term] id: GO:0060431 name: primary lung bud formation namespace: biological_process def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung] synonym: "lung formation" EXACT [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048645 ! animal organ formation is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis is_a: GO:0060572 ! morphogenesis of an epithelial bud intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002048 ! results in formation of lung relationship: RO:0002297 UBERON:0002048 ! results in formation of lung [Term] id: GO:0060433 name: bronchus development namespace: biological_process def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0030323 ! respiratory tube development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002185 ! results in development of bronchus relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0002185 ! results in development of bronchus [Term] id: GO:0060434 name: bronchus morphogenesis namespace: biological_process def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus relationship: BFO:0000050 GO:0060433 ! part of bronchus development relationship: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus [Term] id: GO:0060437 name: lung growth namespace: biological_process def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002048 ! results in growth of lung relationship: BFO:0000050 GO:0030324 ! part of lung development relationship: RO:0002343 UBERON:0002048 ! results in growth of lung [Term] id: GO:0060438 name: trachea development namespace: biological_process def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001005 ! results in development of respiratory airway relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0001005 ! results in development of respiratory airway [Term] id: GO:0060439 name: trachea morphogenesis namespace: biological_process def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway relationship: BFO:0000050 GO:0060438 ! part of trachea development relationship: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway [Term] id: GO:0060440 name: trachea formation namespace: biological_process def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] is_a: GO:0048645 ! animal organ formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001005 ! results in formation of respiratory airway relationship: BFO:0000050 GO:0060439 ! part of trachea morphogenesis relationship: RO:0002297 UBERON:0001005 ! results in formation of respiratory airway [Term] id: GO:0060441 name: epithelial tube branching involved in lung morphogenesis namespace: biological_process def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung] synonym: "lung branching morphogenesis" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis [Term] id: GO:0060452 name: positive regulation of cardiac muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction is_a: GO:0055117 ! regulation of cardiac muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction relationship: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction [Term] id: GO:0060456 name: positive regulation of digestive system process namespace: biological_process def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022600 ! positively regulates digestive system process relationship: RO:0002213 GO:0022600 ! positively regulates digestive system process [Term] id: GO:0060457 name: negative regulation of digestive system process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] is_a: GO:0044058 ! regulation of digestive system process is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022600 ! negatively regulates digestive system process relationship: RO:0002212 GO:0022600 ! negatively regulates digestive system process [Term] id: GO:0060458 name: right lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0030324 ! lung development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002167 ! results in development of right lung relationship: RO:0002296 UBERON:0002167 ! results in development of right lung [Term] id: GO:0060459 name: left lung development namespace: biological_process def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] synonym: "left pulmonary development" EXACT [GOC:dph] is_a: GO:0030324 ! lung development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002168 ! results in development of left lung relationship: RO:0002296 UBERON:0002168 ! results in development of left lung [Term] id: GO:0060460 name: left lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph] is_a: GO:0060425 ! lung morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung relationship: BFO:0000050 GO:0060459 ! part of left lung development relationship: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung [Term] id: GO:0060461 name: right lung morphogenesis namespace: biological_process def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung] is_a: GO:0060425 ! lung morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung relationship: BFO:0000050 GO:0060458 ! part of right lung development relationship: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung [Term] id: GO:0060465 name: pharynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk] synonym: "pharyngeal development" RELATED [] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006562 ! results in development of pharynx relationship: BFO:0000050 GO:0048565 ! part of digestive tract development relationship: RO:0002296 UBERON:0006562 ! results in development of pharynx [Term] id: GO:0060467 name: negative regulation of fertilization namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009566 ! negatively regulates fertilization relationship: RO:0002212 GO:0009566 ! negatively regulates fertilization [Term] id: GO:0060468 name: prevention of polyspermy namespace: biological_process def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] synonym: "polyspermy block" EXACT [GOC:dph] is_a: GO:0060467 ! negative regulation of fertilization intersection_of: GO:0060467 ! negative regulation of fertilization intersection_of: BFO:0000050 GO:0007343 ! part of egg activation relationship: BFO:0000050 GO:0007343 ! part of egg activation [Term] id: GO:0060479 name: lung cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060485 name: mesenchyme development namespace: biological_process def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph] synonym: "mesenchymal development" EXACT [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003104 ! results in development of mesenchyme relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0003104 ! results in development of mesenchyme [Term] id: GO:0060487 name: lung epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation is_a: GO:0060479 ! lung cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung relationship: BFO:0000050 GO:0060428 ! part of lung epithelium development relationship: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung [Term] id: GO:0060491 name: regulation of cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030031 ! regulates cell projection assembly relationship: RO:0002211 GO:0030031 ! regulates cell projection assembly [Term] id: GO:0060495 name: cell-cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung] synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0030324 ! part of lung development relationship: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060496 name: mesenchymal-epithelial cell signaling involved in lung development namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung] synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling intersection_of: BFO:0000050 GO:0030324 ! part of lung development [Term] id: GO:0060497 name: mesenchymal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph] synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell relationship: RO:0002232 CL:0000223 ! has end location endodermal cell [Term] id: GO:0060501 name: positive regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis [Term] id: GO:0060502 name: epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0050673 ! epithelial cell proliferation intersection_of: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis relationship: BFO:0000050 GO:0060428 ! part of lung epithelium development [Term] id: GO:0060532 name: bronchus cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] synonym: "pulmonary cartilage development" EXACT [] is_a: GO:0051216 ! cartilage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus relationship: BFO:0000050 GO:0060433 ! part of bronchus development relationship: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus creation_date: 2009-04-10T08:12:06Z [Term] id: GO:0060533 name: bronchus cartilage morphogenesis namespace: biological_process def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus relationship: BFO:0000050 GO:0060434 ! part of bronchus morphogenesis relationship: BFO:0000050 GO:0060532 ! part of bronchus cartilage development relationship: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus creation_date: 2009-04-10T08:47:41Z [Term] id: GO:0060534 name: trachea cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051216 ! cartilage development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage relationship: BFO:0000050 GO:0060438 ! part of trachea development relationship: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage creation_date: 2009-04-10T09:00:18Z [Term] id: GO:0060535 name: trachea cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] is_a: GO:0060536 ! cartilage morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage relationship: BFO:0000050 GO:0060439 ! part of trachea morphogenesis relationship: BFO:0000050 GO:0060534 ! part of trachea cartilage development relationship: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage creation_date: 2009-04-10T09:07:48Z [Term] id: GO:0060536 name: cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph] is_a: GO:0009887 ! animal organ morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element relationship: BFO:0000050 GO:0051216 ! part of cartilage development relationship: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element creation_date: 2009-04-10T09:13:27Z [Term] id: GO:0060537 name: muscle tissue development namespace: biological_process def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002385 ! results in development of muscle tissue relationship: RO:0002296 UBERON:0002385 ! results in development of muscle tissue creation_date: 2009-04-10T08:05:37Z [Term] id: GO:0060538 name: skeletal muscle organ development namespace: biological_process def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] is_a: GO:0007517 ! muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate creation_date: 2009-04-10T08:25:12Z [Term] id: GO:0060539 name: diaphragm development namespace: biological_process def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph] is_a: GO:0060538 ! skeletal muscle organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001103 ! results in development of diaphragm relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002296 UBERON:0001103 ! results in development of diaphragm creation_date: 2009-04-10T08:44:56Z [Term] id: GO:0060540 name: diaphragm morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph] is_a: GO:0048644 ! muscle organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm relationship: BFO:0000050 GO:0060539 ! part of diaphragm development relationship: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm creation_date: 2009-04-10T08:47:51Z [Term] id: GO:0060541 name: respiratory system development namespace: biological_process def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] subset: goslim_drosophila is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001004 ! results in development of respiratory system relationship: RO:0002296 UBERON:0001004 ! results in development of respiratory system creation_date: 2009-04-10T08:55:42Z [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0060561 name: apoptotic process involved in morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] synonym: "apoptosis involved in development" RELATED [] synonym: "apoptosis involved in morphogenesis" NARROW [] synonym: "morphogenetic apoptosis" RELATED [GOC:dph] is_a: GO:1902742 ! apoptotic process involved in development intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis creation_date: 2009-04-28T09:17:27Z [Term] id: GO:0060562 name: epithelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0035239 ! tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube relationship: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube creation_date: 2009-04-28T09:33:36Z [Term] id: GO:0060563 name: neuroepithelial cell differentiation namespace: biological_process def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell relationship: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell creation_date: 2009-04-29T01:50:05Z [Term] id: GO:0060571 name: morphogenesis of an epithelial fold namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph] synonym: "epithelial folding" EXACT [GOC:dph] synonym: "folding of an epithelial sheet" RELATED [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold relationship: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold creation_date: 2009-04-30T09:27:17Z [Term] id: GO:0060572 name: morphogenesis of an epithelial bud namespace: biological_process def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph] is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud relationship: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud creation_date: 2009-04-30T09:38:35Z [Term] id: GO:0060577 name: pulmonary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph] synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein relationship: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein creation_date: 2009-05-06T08:44:04Z [Term] id: GO:0060578 name: superior vena cava morphogenesis namespace: biological_process def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] is_a: GO:0048845 ! venous blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava relationship: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava creation_date: 2009-05-06T08:47:21Z [Term] id: GO:0060581 name: cell fate commitment involved in pattern specification namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: BFO:0000050 GO:0007389 ! part of pattern specification process relationship: BFO:0000050 GO:0007389 ! part of pattern specification process creation_date: 2009-05-07T12:40:55Z [Term] id: GO:0060591 name: chondroblast differentiation namespace: biological_process def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph] synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast relationship: BFO:0000050 GO:0051216 ! part of cartilage development relationship: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast creation_date: 2009-05-11T07:47:36Z [Term] id: GO:0060612 name: adipose tissue development namespace: biological_process def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph] synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001013 ! results in development of adipose tissue relationship: BFO:0000050 GO:0048513 ! part of animal organ development relationship: RO:0002296 UBERON:0001013 ! results in development of adipose tissue creation_date: 2009-05-15T12:36:28Z [Term] id: GO:0060623 name: regulation of chromosome condensation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030261 ! regulates chromosome condensation relationship: RO:0002211 GO:0030261 ! regulates chromosome condensation creation_date: 2009-05-18T02:12:13Z [Term] id: GO:0060627 name: regulation of vesicle-mediated transport namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport relationship: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport created_by: dph creation_date: 2009-05-18T02:29:43Z [Term] id: GO:0060631 name: regulation of meiosis I namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] is_a: GO:0040020 ! regulation of meiotic nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007127 ! regulates meiosis I relationship: RO:0002211 GO:0007127 ! regulates meiosis I created_by: dph creation_date: 2009-05-18T02:55:19Z [Term] id: GO:0060632 name: regulation of microtubule-based movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007018 ! regulates microtubule-based movement relationship: RO:0002211 GO:0007018 ! regulates microtubule-based movement creation_date: 2009-05-18T03:07:02Z [Term] id: GO:0060638 name: mesenchymal-epithelial cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph] synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell intersection_of: RO:0002232 CL:0000066 ! has end location epithelial cell relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell relationship: RO:0002232 CL:0000066 ! has end location epithelial cell creation_date: 2009-05-19T03:59:05Z [Term] id: GO:0060684 name: epithelial-mesenchymal cell signaling namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000066 ! has start location epithelial cell intersection_of: RO:0002232 CL:0008019 ! has end location mesenchymal cell relationship: RO:0002231 CL:0000066 ! has start location epithelial cell relationship: RO:0002232 CL:0008019 ! has end location mesenchymal cell creation_date: 2009-06-03T06:36:46Z [Term] id: GO:0060688 name: regulation of morphogenesis of a branching structure namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure relationship: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure creation_date: 2009-06-05T12:41:44Z [Term] id: GO:0060759 name: regulation of response to cytokine stimulus namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034097 ! regulates response to cytokine relationship: RO:0002211 GO:0034097 ! regulates response to cytokine creation_date: 2009-06-22T02:56:12Z [Term] id: GO:0060760 name: positive regulation of response to cytokine stimulus namespace: biological_process def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034097 ! positively regulates response to cytokine relationship: RO:0002213 GO:0034097 ! positively regulates response to cytokine creation_date: 2009-06-22T02:58:04Z [Term] id: GO:0060761 name: negative regulation of response to cytokine stimulus namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0060759 ! regulation of response to cytokine stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034097 ! negatively regulates response to cytokine relationship: RO:0002212 GO:0034097 ! negatively regulates response to cytokine creation_date: 2009-06-22T02:59:57Z [Term] id: GO:0060784 name: regulation of cell proliferation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0042127 ! regulation of cell population proliferation intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue creation_date: 2009-07-31T01:46:28Z [Term] id: GO:0060785 name: regulation of apoptosis involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0042981 ! regulation of apoptotic process intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue creation_date: 2009-07-31T01:49:54Z [Term] id: GO:0060786 name: regulation of cell differentiation involved in tissue homeostasis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0045595 ! regulation of cell differentiation intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue creation_date: 2009-07-31T01:55:19Z [Term] id: GO:0060788 name: ectodermal placode formation namespace: biological_process def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0005085 ! results in formation of ectodermal placode relationship: BFO:0000050 GO:0071697 ! part of ectodermal placode morphogenesis relationship: RO:0002297 UBERON:0005085 ! results in formation of ectodermal placode creation_date: 2009-08-04T12:15:57Z [Term] id: GO:0060795 name: cell fate commitment involved in formation of primary germ layer namespace: biological_process def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045165 ! cell fate commitment intersection_of: GO:0045165 ! cell fate commitment intersection_of: BFO:0000050 GO:0001704 ! part of formation of primary germ layer relationship: BFO:0000050 GO:0001704 ! part of formation of primary germ layer creation_date: 2009-08-04T03:11:22Z [Term] id: GO:0060837 name: blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell relationship: BFO:0000050 GO:0001568 ! part of blood vessel development relationship: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell creation_date: 2009-08-11T03:47:36Z [Term] id: GO:0060840 name: artery development namespace: biological_process def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001637 ! results in development of artery relationship: RO:0002296 UBERON:0001637 ! results in development of artery creation_date: 2009-08-12T10:10:51Z [Term] id: GO:0060841 name: venous blood vessel development namespace: biological_process def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001638 ! results in development of vein relationship: RO:0002296 UBERON:0001638 ! results in development of vein creation_date: 2009-08-12T10:14:07Z [Term] id: GO:0060842 name: arterial endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery relationship: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery creation_date: 2009-08-12T10:41:34Z [Term] id: GO:0060843 name: venous endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell relationship: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell creation_date: 2009-08-12T10:43:40Z [Term] id: GO:0060896 name: neural plate pattern specification namespace: biological_process def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb] xref: Reactome:R-HSA-9834899 "Specification of the neural plate border" is_a: GO:0007389 ! pattern specification process creation_date: 2009-08-13T02:06:27Z [Term] id: GO:0060897 name: neural plate regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0060896 ! neural plate pattern specification creation_date: 2009-08-13T02:09:04Z [Term] id: GO:0060900 name: embryonic camera-type eye formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0048596 ! part of embryonic camera-type eye morphogenesis creation_date: 2009-08-13T02:26:54Z [Term] id: GO:0060907 name: positive regulation of macrophage cytokine production namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb] is_a: GO:0010935 ! regulation of macrophage cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010934 ! positively regulates macrophage cytokine production relationship: RO:0002213 GO:0010934 ! positively regulates macrophage cytokine production creation_date: 2009-09-04T02:32:18Z [Term] id: GO:0060914 name: heart formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "cardiogenesis" RELATED [GOC:mtg_heart] xref: Reactome:R-HSA-9733709 "Cardiogenesis" is_a: GO:0048645 ! animal organ formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000948 ! results in formation of heart relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: RO:0002297 UBERON:0000948 ! results in formation of heart creation_date: 2009-09-17T09:02:13Z [Term] id: GO:0060915 name: mesenchymal cell differentiation involved in lung development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0030324 ! part of lung development relationship: BFO:0000050 GO:0030324 ! part of lung development creation_date: 2009-09-18T11:45:33Z [Term] id: GO:0060916 name: mesenchymal cell proliferation involved in lung development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph] is_a: GO:0010463 ! mesenchymal cell proliferation intersection_of: GO:0010463 ! mesenchymal cell proliferation intersection_of: BFO:0000050 GO:0030324 ! part of lung development relationship: BFO:0000050 GO:0030324 ! part of lung development creation_date: 2009-09-18T11:50:17Z [Term] id: GO:0060920 name: cardiac pacemaker cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell differentiation" BROAD [] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte relationship: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte creation_date: 2009-09-29T11:01:31Z [Term] id: GO:0060921 name: sinoatrial node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart] synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060920 ! cardiac pacemaker cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node relationship: BFO:0000050 GO:0003163 ! part of sinoatrial node development relationship: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node creation_date: 2009-09-29T11:03:30Z [Term] id: GO:0060922 name: atrioventricular node cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart] synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart] is_a: GO:0003292 ! cardiac septum cell differentiation is_a: GO:0060920 ! cardiac pacemaker cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node relationship: BFO:0000050 GO:0003162 ! part of atrioventricular node development relationship: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node creation_date: 2009-09-29T11:07:06Z [Term] id: GO:0060926 name: cardiac pacemaker cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "pacemaker cell development" BROAD [] is_a: GO:0055013 ! cardiac muscle cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002072 ! results in development of nodal myocyte relationship: BFO:0000050 GO:0060920 ! part of cardiac pacemaker cell differentiation relationship: RO:0002296 CL:0002072 ! results in development of nodal myocyte creation_date: 2009-09-29T11:51:55Z [Term] id: GO:0060928 name: atrioventricular node cell development namespace: biological_process def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "AV node cell development" EXACT [GOC:mtg_heart] is_a: GO:0060926 ! cardiac pacemaker cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node relationship: BFO:0000050 GO:0060922 ! part of atrioventricular node cell differentiation relationship: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node creation_date: 2009-09-29T11:59:26Z [Term] id: GO:0060931 name: sinoatrial node cell development namespace: biological_process def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] synonym: "SA node cell development" EXACT [GOC:mtg_heart] synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0060926 ! cardiac pacemaker cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node relationship: BFO:0000050 GO:0060921 ! part of sinoatrial node cell differentiation relationship: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node creation_date: 2009-09-29T12:05:47Z [Term] id: GO:0060932 name: His-Purkinje system cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055007 ! cardiac muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development relationship: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell creation_date: 2009-09-29T01:10:32Z [Term] id: GO:0060933 name: His-Purkinje system cell development namespace: biological_process def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell relationship: BFO:0000050 GO:0060932 ! part of His-Purkinje system cell differentiation relationship: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell creation_date: 2009-09-29T01:15:02Z [Term] id: GO:0060935 name: cardiac fibroblast cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue relationship: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue creation_date: 2009-09-29T01:20:04Z [Term] id: GO:0060936 name: cardiac fibroblast cell development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue relationship: BFO:0000050 GO:0060935 ! part of cardiac fibroblast cell differentiation relationship: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue creation_date: 2009-09-29T01:23:03Z [Term] id: GO:0060945 name: cardiac neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart] synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048934 ! peripheral nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron creation_date: 2009-09-29T02:45:33Z [Term] id: GO:0060946 name: cardiac blood vessel endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation is_a: GO:0060837 ! blood vessel endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell relationship: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell creation_date: 2009-09-29T02:48:55Z [Term] id: GO:0060950 name: cardiac glial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell relationship: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell creation_date: 2009-09-29T03:06:37Z [Term] id: GO:0060952 name: cardiac glial cell development namespace: biological_process def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart] is_a: GO:0021782 ! glial cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010020 ! results in development of cardiac glial cell relationship: BFO:0000050 GO:0060950 ! part of cardiac glial cell differentiation relationship: RO:0002296 CL:0010020 ! results in development of cardiac glial cell creation_date: 2009-09-29T03:09:24Z [Term] id: GO:0060956 name: endocardial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0003348 ! cardiac endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell relationship: BFO:0000050 GO:0003157 ! part of endocardium development relationship: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell creation_date: 2009-09-29T03:20:39Z [Term] id: GO:0060958 name: endocardial cell development namespace: biological_process def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] is_a: GO:0001885 ! endothelial cell development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0002350 ! results in development of endocardial cell relationship: BFO:0000050 GO:0060956 ! part of endocardial cell differentiation relationship: RO:0002296 CL:0002350 ! results in development of endocardial cell creation_date: 2009-09-29T03:26:59Z [Term] id: GO:0060959 name: cardiac neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart neuron development" EXACT [GOC:mtg_heart] is_a: GO:0048935 ! peripheral nervous system neuron development is_a: GO:0055006 ! cardiac cell development intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0010022 ! results in development of cardiac neuron relationship: BFO:0000050 GO:0060945 ! part of cardiac neuron differentiation relationship: RO:0002296 CL:0010022 ! results in development of cardiac neuron creation_date: 2009-09-30T10:14:56Z [Term] id: GO:0060973 name: cell migration involved in heart development namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0007507 ! part of heart development creation_date: 2009-10-06T10:53:49Z [Term] id: GO:0060974 name: cell migration involved in heart formation namespace: biological_process def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060914 ! part of heart formation relationship: BFO:0000050 GO:0060914 ! part of heart formation creation_date: 2009-10-06T10:56:33Z [Term] id: GO:0060976 name: coronary vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart blood vessel development" EXACT [GOC:mtg_heart] synonym: "heart vasculature development" EXACT [GOC:mtg_heart] is_a: GO:0001568 ! blood vessel development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel relationship: BFO:0000050 GO:0007507 ! part of heart development relationship: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel creation_date: 2009-10-06T12:15:23Z [Term] id: GO:0060977 name: coronary vasculature morphogenesis namespace: biological_process def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart] synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart] synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0048514 ! blood vessel morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel relationship: BFO:0000050 GO:0060976 ! part of coronary vasculature development relationship: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel creation_date: 2009-10-06T12:28:23Z [Term] id: GO:0060978 name: angiogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart] synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart] synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart] synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001525 ! angiogenesis intersection_of: GO:0001525 ! angiogenesis intersection_of: BFO:0000050 GO:0060976 ! part of coronary vasculature development relationship: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis creation_date: 2009-10-06T02:02:12Z [Term] id: GO:0060979 name: vasculogenesis involved in coronary vascular morphogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart] synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart] synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0001570 ! vasculogenesis intersection_of: GO:0001570 ! vasculogenesis intersection_of: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis relationship: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis creation_date: 2009-10-06T02:19:42Z [Term] id: GO:0060980 name: cell migration involved in coronary vasculogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart] is_a: GO:0035441 ! cell migration involved in vasculogenesis is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060979 ! part of vasculogenesis involved in coronary vascular morphogenesis relationship: BFO:0000050 GO:0060979 ! part of vasculogenesis involved in coronary vascular morphogenesis creation_date: 2009-10-06T02:33:06Z [Term] id: GO:0060981 name: cell migration involved in coronary angiogenesis namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0060978 ! part of angiogenesis involved in coronary vascular morphogenesis relationship: BFO:0000050 GO:0060978 ! part of angiogenesis involved in coronary vascular morphogenesis creation_date: 2009-10-06T02:49:12Z [Term] id: GO:0060986 name: endocrine hormone secretion namespace: biological_process def: "The regulated release of a hormone into the circulatory system." [GOC:dph] is_a: GO:0046879 ! hormone secretion relationship: BFO:0000050 GO:0050886 ! part of endocrine process creation_date: 2010-01-11T09:03:48Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] xref: Reactome:R-HSA-199991 "Membrane Trafficking" is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0016020 ! results in organization of membrane relationship: RO:0002592 GO:0016020 ! results in organization of membrane created_by: jl creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061025 name: membrane fusion namespace: biological_process def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cellular membrane fusion" EXACT [] synonym: "single-organism membrane fusion" RELATED [] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0061024 ! membrane organization intersection_of: GO:0061024 ! membrane organization intersection_of: RO:0012008 GO:0016020 ! results in fusion of membrane relationship: RO:0012008 GO:0016020 ! results in fusion of membrane creation_date: 2010-02-08T02:48:06Z [Term] id: GO:0061032 name: visceral serous pericardium development namespace: biological_process def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf] synonym: "epicardium development" EXACT [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium relationship: BFO:0000050 GO:0060039 ! part of pericardium development relationship: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium creation_date: 2010-02-09T09:52:49Z [Term] id: GO:0061035 name: regulation of cartilage development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051216 ! regulates cartilage development relationship: RO:0002211 GO:0051216 ! regulates cartilage development creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061036 name: positive regulation of cartilage development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051216 ! positively regulates cartilage development relationship: RO:0002213 GO:0051216 ! positively regulates cartilage development creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061037 name: negative regulation of cartilage development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051216 ! negatively regulates cartilage development relationship: RO:0002212 GO:0051216 ! negatively regulates cartilage development creation_date: 2010-02-09T03:41:35Z [Term] id: GO:0061040 name: female gonad morphogenesis namespace: biological_process def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph] synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0035262 ! gonad morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary relationship: BFO:0000050 GO:0008585 ! part of female gonad development relationship: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary creation_date: 2010-02-22T11:29:28Z [Term] id: GO:0061046 name: regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis creation_date: 2010-02-25T10:41:38Z [Term] id: GO:0061047 name: positive regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis creation_date: 2010-02-25T10:50:01Z [Term] id: GO:0061048 name: negative regulation of branching involved in lung morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis relationship: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis creation_date: 2010-02-25T10:51:31Z [Term] id: GO:0061049 name: cell growth involved in cardiac muscle cell development namespace: biological_process def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph] synonym: "cardiomyocyte growth" RELATED [GOC:dph] synonym: "heart muscle cell growth" RELATED [GOC:dph] is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0016049 ! cell growth intersection_of: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development relationship: BFO:0000050 GO:0003301 ! part of physiological cardiac muscle hypertrophy relationship: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development creation_date: 2010-02-25T12:56:07Z [Term] id: GO:0061050 name: regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0055021 ! regulation of cardiac muscle tissue growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development relationship: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development creation_date: 2010-02-25T01:05:16Z [Term] id: GO:0061051 name: positive regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development relationship: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development creation_date: 2010-02-25T01:08:08Z [Term] id: GO:0061052 name: negative regulation of cell growth involved in cardiac muscle cell development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development relationship: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development creation_date: 2010-02-25T01:11:30Z [Term] id: GO:0061053 name: somite development namespace: biological_process def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002329 ! results in development of somite relationship: BFO:0000050 GO:0009790 ! part of embryo development relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002296 UBERON:0002329 ! results in development of somite creation_date: 2010-03-02T12:05:13Z [Term] id: GO:0061054 name: dermatome development namespace: biological_process def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004016 ! results in development of dermatome relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002296 UBERON:0004016 ! results in development of dermatome creation_date: 2010-03-02T12:07:37Z [Term] id: GO:0061055 name: myotome development namespace: biological_process def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003082 ! results in development of myotome relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002296 UBERON:0003082 ! results in development of myotome creation_date: 2010-03-02T12:11:01Z [Term] id: GO:0061056 name: sclerotome development namespace: biological_process def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003089 ! results in development of sclerotome relationship: BFO:0000050 GO:0061053 ! part of somite development relationship: RO:0002296 UBERON:0003089 ! results in development of sclerotome creation_date: 2010-03-02T12:12:40Z [Term] id: GO:0061061 name: muscle structure development namespace: biological_process def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] subset: goslim_drosophila is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005090 ! results in development of muscle structure relationship: RO:0002296 UBERON:0005090 ! results in development of muscle structure creation_date: 2010-03-09T08:55:14Z [Term] id: GO:0061072 name: iris morphogenesis namespace: biological_process def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris creation_date: 2010-03-16T10:48:42Z [Term] id: GO:0061073 name: ciliary body morphogenesis namespace: biological_process def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis relationship: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body creation_date: 2010-03-16T10:55:19Z [Term] id: GO:0061074 name: regulation of neural retina development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003407 ! regulates neural retina development relationship: RO:0002211 GO:0003407 ! regulates neural retina development creation_date: 2010-03-16T11:47:05Z [Term] id: GO:0061075 name: positive regulation of neural retina development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902868 ! positive regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003407 ! positively regulates neural retina development relationship: RO:0002213 GO:0003407 ! positively regulates neural retina development creation_date: 2010-03-16T11:59:48Z [Term] id: GO:0061076 name: negative regulation of neural retina development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] is_a: GO:0061074 ! regulation of neural retina development is_a: GO:1902867 ! negative regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003407 ! negatively regulates neural retina development relationship: RO:0002212 GO:0003407 ! negatively regulates neural retina development creation_date: 2010-03-16T12:46:11Z [Term] id: GO:0061080 name: right horn of sinus venosus development namespace: biological_process def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus relationship: BFO:0000050 GO:0003235 ! part of sinus venosus development relationship: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus creation_date: 2010-04-08T02:45:10Z [Term] id: GO:0061081 name: positive regulation of myeloid leukocyte cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph] synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061082 ! positively regulates myeloid leukocyte cytokine production relationship: RO:0002213 GO:0061082 ! positively regulates myeloid leukocyte cytokine production creation_date: 2010-04-13T11:26:41Z [Term] id: GO:0061082 name: myeloid leukocyte cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. subset: gocheck_do_not_annotate is_a: GO:0002367 ! cytokine production involved in immune response creation_date: 2010-04-13T11:29:42Z [Term] id: GO:0061100 name: lung neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] is_a: GO:0061101 ! neuroendocrine cell differentiation is_a: GO:0061140 ! lung secretory cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell relationship: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell creation_date: 2010-04-27T03:28:46Z [Term] id: GO:0061101 name: neuroendocrine cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph] is_a: GO:0030182 ! neuron differentiation is_a: GO:0060563 ! neuroepithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell relationship: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell creation_date: 2010-04-28T09:42:20Z [Term] id: GO:0061109 name: dense core granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] synonym: "dense core granule organisation" EXACT [GOC:mah] is_a: GO:0033363 ! secretory granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031045 ! results in organization of dense core granule relationship: RO:0002592 GO:0031045 ! results in organization of dense core granule creation_date: 2010-05-01T09:34:37Z [Term] id: GO:0061111 name: epithelial-mesenchymal cell signaling involved in lung development namespace: biological_process def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph] synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah] is_a: GO:0060495 ! cell-cell signaling involved in lung development is_a: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling intersection_of: BFO:0000050 GO:0030324 ! part of lung development creation_date: 2010-05-05T11:14:38Z [Term] id: GO:0061117 name: negative regulation of heart growth namespace: biological_process def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] is_a: GO:0046621 ! negative regulation of organ growth is_a: GO:0060420 ! regulation of heart growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060419 ! negatively regulates heart growth relationship: RO:0002212 GO:0060419 ! negatively regulates heart growth creation_date: 2010-05-17T07:31:28Z [Term] id: GO:0061138 name: morphogenesis of a branching epithelium namespace: biological_process def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0002009 ! morphogenesis of an epithelium creation_date: 2010-05-25T09:05:34Z [Term] id: GO:0061140 name: lung secretory cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph] is_a: GO:0060487 ! lung epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell relationship: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell creation_date: 2010-05-25T09:28:53Z [Term] id: GO:0061147 name: endocardial endothelium development namespace: biological_process def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] is_a: GO:0003158 ! endothelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium relationship: BFO:0000050 GO:0003157 ! part of endocardium development relationship: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium creation_date: 2010-06-03T09:15:31Z [Term] id: GO:0061148 name: extracellular matrix organization involved in endocardium development namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0030198 ! extracellular matrix organization intersection_of: BFO:0000050 GO:0003157 ! part of endocardium development relationship: BFO:0000050 GO:0003157 ! part of endocardium development creation_date: 2010-06-03T09:18:02Z [Term] id: GO:0061152 name: trachea submucosa development namespace: biological_process def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea relationship: BFO:0000050 GO:0060438 ! part of trachea development relationship: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea creation_date: 2010-06-07T09:58:40Z [Term] id: GO:0061154 name: endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf] is_a: GO:0003159 ! morphogenesis of an endothelium is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube relationship: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube creation_date: 2010-06-15T09:05:00Z [Term] id: GO:0061155 name: pulmonary artery endothelial tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf] is_a: GO:0061154 ! endothelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium relationship: BFO:0000050 GO:0061156 ! part of pulmonary artery morphogenesis relationship: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium creation_date: 2010-06-15T09:09:04Z [Term] id: GO:0061156 name: pulmonary artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery relationship: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery creation_date: 2010-06-15T09:13:47Z [Term] id: GO:0061181 name: regulation of chondrocyte development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002063 ! regulates chondrocyte development relationship: RO:0002211 GO:0002063 ! regulates chondrocyte development creation_date: 2010-07-14T08:28:52Z [Term] id: GO:0061182 name: negative regulation of chondrocyte development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0032331 ! negative regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development relationship: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development creation_date: 2010-07-14T08:33:05Z [Term] id: GO:0061183 name: regulation of dermatome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061054 ! regulates dermatome development relationship: RO:0002211 GO:0061054 ! regulates dermatome development creation_date: 2010-07-14T08:40:26Z [Term] id: GO:0061184 name: positive regulation of dermatome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0040019 ! positive regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061054 ! positively regulates dermatome development relationship: RO:0002213 GO:0061054 ! positively regulates dermatome development creation_date: 2010-07-14T08:42:03Z [Term] id: GO:0061185 name: negative regulation of dermatome development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] is_a: GO:0045992 ! negative regulation of embryonic development is_a: GO:0061183 ! regulation of dermatome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061054 ! negatively regulates dermatome development relationship: RO:0002212 GO:0061054 ! negatively regulates dermatome development creation_date: 2010-07-14T08:43:08Z [Term] id: GO:0061189 name: positive regulation of sclerotome development namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0061190 ! regulation of sclerotome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061056 ! positively regulates sclerotome development relationship: RO:0002213 GO:0061056 ! positively regulates sclerotome development creation_date: 2010-07-14T09:17:23Z [Term] id: GO:0061190 name: regulation of sclerotome development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061056 ! regulates sclerotome development relationship: RO:0002211 GO:0061056 ! regulates sclerotome development creation_date: 2010-07-14T09:19:47Z [Term] id: GO:0061193 name: taste bud development namespace: biological_process def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001727 ! results in development of taste bud relationship: BFO:0000050 GO:0043586 ! part of tongue development relationship: RO:0002296 UBERON:0001727 ! results in development of taste bud creation_date: 2010-07-27T10:55:08Z [Term] id: GO:0061194 name: taste bud morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0090596 ! sensory organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001727 ! results in morphogenesis of taste bud relationship: BFO:0000050 GO:0043587 ! part of tongue morphogenesis relationship: BFO:0000050 GO:0061193 ! part of taste bud development relationship: RO:0002298 UBERON:0001727 ! results in morphogenesis of taste bud creation_date: 2010-07-27T11:01:31Z [Term] id: GO:0061195 name: taste bud formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001727 ! results in formation of taste bud relationship: BFO:0000050 GO:0061194 ! part of taste bud morphogenesis relationship: RO:0002297 UBERON:0001727 ! results in formation of taste bud creation_date: 2010-07-27T12:22:26Z [Term] id: GO:0061298 name: retina vasculature development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] synonym: "retinal vasculature development" EXACT [GOC:dph] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye relationship: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina creation_date: 2010-09-06T03:27:06Z [Term] id: GO:0061299 name: retina vasculature morphogenesis in camera-type eye namespace: biological_process def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph] synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina relationship: BFO:0000050 GO:0061298 ! part of retina vasculature development in camera-type eye relationship: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina creation_date: 2010-09-06T03:28:25Z [Term] id: GO:0061300 name: cerebellum vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0001944 ! vasculature development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006694 ! results in development of cerebellum vasculature relationship: RO:0002296 UBERON:0006694 ! results in development of cerebellum vasculature creation_date: 2010-09-06T03:36:40Z [Term] id: GO:0061301 name: cerebellum vasculature morphogenesis namespace: biological_process def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0006694 ! results in morphogenesis of cerebellum vasculature relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: BFO:0000050 GO:0061300 ! part of cerebellum vasculature development relationship: RO:0002298 UBERON:0006694 ! results in morphogenesis of cerebellum vasculature creation_date: 2010-09-06T03:38:05Z [Term] id: GO:0061303 name: cornea development in camera-type eye namespace: biological_process def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000964 ! results in development of cornea relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development relationship: RO:0002296 UBERON:0000964 ! results in development of cornea creation_date: 2010-09-14T02:09:08Z [Term] id: GO:0061304 name: retinal blood vessel morphogenesis namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] is_a: GO:0048514 ! blood vessel morphogenesis is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel relationship: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel creation_date: 2010-09-16T09:02:59Z [Term] id: GO:0061307 name: cardiac neural crest cell differentiation involved in heart development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442] is_a: GO:0014033 ! neural crest cell differentiation is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0014033 ! neural crest cell differentiation intersection_of: BFO:0000050 GO:0007507 ! part of heart development creation_date: 2010-09-23T08:50:56Z [Term] id: GO:0061308 name: cardiac neural crest cell development involved in heart development namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0014032 ! neural crest cell development intersection_of: GO:0014032 ! neural crest cell development intersection_of: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0061307 ! part of cardiac neural crest cell differentiation involved in heart development creation_date: 2010-09-23T09:01:49Z [Term] id: GO:0061309 name: cardiac neural crest cell development involved in outflow tract morphogenesis namespace: biological_process def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development intersection_of: GO:0014032 ! neural crest cell development intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis creation_date: 2010-09-23T09:08:37Z [Term] id: GO:0061311 name: cell surface receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: BFO:0000050 GO:0007507 ! part of heart development relationship: BFO:0000050 GO:0007507 ! part of heart development creation_date: 2010-09-23T09:18:32Z [Term] id: GO:0061323 name: cell proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2010-09-28T09:05:26Z [Term] id: GO:0061325 name: cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis creation_date: 2010-09-28T09:29:30Z [Term] id: GO:0061337 name: cardiac conduction namespace: biological_process def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph] xref: Reactome:R-HSA-5576891 "Cardiac conduction" is_a: GO:0008016 ! regulation of heart contraction creation_date: 2010-09-29T08:46:05Z [Term] id: GO:0061343 name: cell adhesion involved in heart morphogenesis namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0007155 ! cell adhesion intersection_of: GO:0007155 ! cell adhesion intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2010-09-29T11:34:06Z [Term] id: GO:0061344 name: regulation of cell adhesion involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] is_a: GO:0030155 ! regulation of cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061343 ! regulates cell adhesion involved in heart morphogenesis relationship: RO:0002211 GO:0061343 ! regulates cell adhesion involved in heart morphogenesis creation_date: 2010-09-29T11:35:27Z [Term] id: GO:0061351 name: neural precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf] is_a: GO:0008283 ! cell population proliferation creation_date: 2010-10-01T11:06:04Z [Term] id: GO:0061385 name: fibroblast proliferation involved in heart morphogenesis namespace: biological_process def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph] is_a: GO:0048144 ! fibroblast proliferation is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0048144 ! fibroblast proliferation intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis creation_date: 2011-02-10T01:41:59Z [Term] id: GO:0061448 name: connective tissue development namespace: biological_process def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002384 ! results in development of connective tissue relationship: RO:0002296 UBERON:0002384 ! results in development of connective tissue creation_date: 2012-03-22T12:53:41Z [Term] id: GO:0061450 name: trophoblast cell migration namespace: biological_process def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000351 ! results in movement of trophoblast cell relationship: BFO:0000050 GO:0007566 ! part of embryo implantation relationship: RO:0002565 CL:0000351 ! results in movement of trophoblast cell creation_date: 2012-07-10T08:38:37Z [Term] id: GO:0061458 name: reproductive system development namespace: biological_process def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000990 ! results in development of reproductive system relationship: RO:0002296 UBERON:0000990 ! results in development of reproductive system creation_date: 2012-08-22T17:47:53Z [Term] id: GO:0061462 name: protein localization to lysosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph] is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome relationship: RO:0002339 GO:0005764 ! has target end location lysosome creation_date: 2012-10-05T10:50:51Z [Term] id: GO:0061484 name: hematopoietic stem cell homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411] is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell creation_date: 2012-12-04T09:41:02Z [Term] id: GO:0061512 name: protein localization to cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005929 ! has target end location cilium relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota relationship: RO:0002339 GO:0005929 ! has target end location cilium creation_date: 2013-03-22T15:41:44Z [Term] id: GO:0061515 name: myeloid cell development namespace: biological_process def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0030097 ! hemopoiesis intersection_of: GO:0048468 ! cell development intersection_of: RO:0002296 CL:0000763 ! results in development of myeloid cell relationship: BFO:0000050 GO:0030099 ! part of myeloid cell differentiation relationship: RO:0002296 CL:0000763 ! results in development of myeloid cell creation_date: 2013-04-18T13:03:16Z [Term] id: GO:0061519 name: macrophage homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904] is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000235 ! acts on population of macrophage relationship: RO:0012003 CL:0000235 ! acts on population of macrophage creation_date: 2013-04-18T13:25:33Z [Term] id: GO:0061523 name: cilium disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "cilium resorption" EXACT [GOC:dph] is_a: GO:0044782 ! cilium organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005929 ! results in disassembly of cilium relationship: RO:0002590 GO:0005929 ! results in disassembly of cilium creation_date: 2013-04-18T14:59:59Z [Term] id: GO:0061524 name: central canal development namespace: biological_process def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002291 ! results in development of central canal of spinal cord relationship: BFO:0000050 GO:0021510 ! part of spinal cord development relationship: RO:0002296 UBERON:0002291 ! results in development of central canal of spinal cord creation_date: 2013-04-20T08:18:31Z [Term] id: GO:0061526 name: acetylcholine secretion namespace: biological_process def: "The regulated release of acetylcholine by a cell." [GOC:dph] is_a: GO:0015870 ! acetylcholine transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:15355 ! has primary input creation_date: 2013-06-21T15:40:39Z [Term] id: GO:0061533 name: norepinephrine secretion, neurotransmission namespace: biological_process def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph] synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph] is_a: GO:0048243 ! norepinephrine secretion is_a: GO:0160043 ! catecholamine secretion, neurotransmission intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:72587 ! has primary input creation_date: 2013-06-21T16:05:08Z [Term] id: GO:0061534 name: gamma-aminobutyric acid secretion, neurotransmission namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014051 ! gamma-aminobutyric acid secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:59888 ! has primary input relationship: BFO:0000050 GO:0051932 ! part of synaptic transmission, GABAergic creation_date: 2013-06-21T16:10:50Z [Term] id: GO:0061535 name: glutamate secretion, neurotransmission namespace: biological_process def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0014047 ! glutamate secretion is_a: GO:0051938 ! L-glutamate import intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: BFO:0000050 GO:0035249 ! part of synaptic transmission, glutamatergic creation_date: 2013-06-21T16:14:47Z [Term] id: GO:0061536 name: glycine secretion namespace: biological_process def: "The controlled release of glycine by a cell." [GOC:dph] is_a: GO:0015816 ! glycine transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2013-06-21T16:18:23Z [Term] id: GO:0061537 name: glycine secretion, neurotransmission namespace: biological_process def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061536 ! glycine secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: BFO:0000050 GO:0060012 ! part of synaptic transmission, glycinergic creation_date: 2013-06-21T16:19:02Z [Term] id: GO:0061548 name: ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "ganglia development" RELATED [GOC:dph] synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl] is_a: GO:0009888 ! tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000045 ! results in development of ganglion relationship: BFO:0000050 GO:0007399 ! part of nervous system development relationship: RO:0002296 UBERON:0000045 ! results in development of ganglion creation_date: 2013-07-10T08:36:12Z [Term] id: GO:0061549 name: sympathetic ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl] synonym: "sympathetic ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion relationship: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development relationship: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion creation_date: 2013-07-10T08:38:01Z [Term] id: GO:0061550 name: cranial ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "cranial ganglia development" RELATED [GOC:dph] is_a: GO:0061548 ! ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development relationship: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion creation_date: 2013-07-10T08:40:14Z [Term] id: GO:0061551 name: trigeminal ganglion development namespace: biological_process def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph] synonym: "trigeminal ganglia development" RELATED [GOC:dph] is_a: GO:0061550 ! cranial ganglion development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion relationship: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion creation_date: 2013-07-10T08:42:19Z [Term] id: GO:0061552 name: ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph] synonym: "ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion relationship: BFO:0000050 GO:0061548 ! part of ganglion development relationship: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion creation_date: 2013-07-10T08:44:57Z [Term] id: GO:0061553 name: ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph] synonym: "ganglia maturation" RELATED [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0000045 ! results in maturation of ganglion relationship: BFO:0000050 GO:0061548 ! part of ganglion development relationship: RO:0002299 UBERON:0000045 ! results in maturation of ganglion creation_date: 2013-07-10T08:45:59Z [Term] id: GO:0061554 name: ganglion formation namespace: biological_process def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "ganglia formation" RELATED [GOC:dph] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000045 ! results in formation of ganglion relationship: BFO:0000050 GO:0061552 ! part of ganglion morphogenesis relationship: RO:0002297 UBERON:0000045 ! results in formation of ganglion creation_date: 2013-07-10T08:51:50Z [Term] id: GO:0061556 name: trigeminal ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph] synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061559 ! cranial ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion relationship: BFO:0000050 GO:0021636 ! part of trigeminal nerve morphogenesis relationship: BFO:0000050 GO:0061551 ! part of trigeminal ganglion development relationship: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion creation_date: 2013-07-10T08:57:12Z [Term] id: GO:0061557 name: trigeminal ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph] synonym: "trigeminal ganglia maturation" RELATED [GOC:dph] is_a: GO:0061558 ! cranial ganglion maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion relationship: BFO:0000050 GO:0021635 ! part of trigeminal nerve maturation relationship: BFO:0000050 GO:0061551 ! part of trigeminal ganglion development relationship: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion creation_date: 2013-07-10T08:58:24Z [Term] id: GO:0061558 name: cranial ganglion maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph] synonym: "cranial ganglia maturation" RELATED [GOC:dph] is_a: GO:0061553 ! ganglion maturation intersection_of: GO:0071695 ! anatomical structure maturation intersection_of: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion relationship: BFO:0000050 GO:0021605 ! part of cranial nerve maturation relationship: BFO:0000050 GO:0061550 ! part of cranial ganglion development relationship: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion creation_date: 2013-07-10T08:59:52Z [Term] id: GO:0061559 name: cranial ganglion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph] synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph] is_a: GO:0061552 ! ganglion morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion relationship: BFO:0000050 GO:0021602 ! part of cranial nerve morphogenesis relationship: BFO:0000050 GO:0061550 ! part of cranial ganglion development relationship: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion creation_date: 2013-07-10T09:02:15Z [Term] id: GO:0061560 name: cranial ganglion formation namespace: biological_process def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "cranial ganglia formation" RELATED [GOC:dph] is_a: GO:0061554 ! ganglion formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001714 ! results in formation of cranial ganglion relationship: BFO:0000050 GO:0061559 ! part of cranial ganglion morphogenesis relationship: RO:0002297 UBERON:0001714 ! results in formation of cranial ganglion creation_date: 2013-07-10T09:07:27Z [Term] id: GO:0061561 name: trigeminal ganglion formation namespace: biological_process def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] synonym: "trigeminal ganglia formation" RELATED [GOC:dph] is_a: GO:0061560 ! cranial ganglion formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001675 ! results in formation of trigeminal ganglion relationship: BFO:0000050 GO:0061556 ! part of trigeminal ganglion morphogenesis relationship: RO:0002297 UBERON:0001675 ! results in formation of trigeminal ganglion creation_date: 2013-07-10T09:08:13Z [Term] id: GO:0061564 name: axon development namespace: biological_process def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] is_a: GO:0031175 ! neuron projection development creation_date: 2013-07-18T14:43:01Z [Term] id: GO:0061572 name: actin filament bundle organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] synonym: "actin filament cable organization" RELATED [GOC:dph] is_a: GO:0007015 ! actin filament organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0032432 ! results in organization of actin filament bundle relationship: RO:0002592 GO:0032432 ! results in organization of actin filament bundle creation_date: 2013-08-02T11:24:11Z [Term] id: GO:0061581 name: corneal epithelial cell migration namespace: biological_process def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] is_a: GO:0010631 ! epithelial cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000575 ! results in movement of corneal epithelial cell relationship: RO:0002565 CL:0000575 ! results in movement of corneal epithelial cell creation_date: 2013-12-23T07:28:29Z [Term] id: GO:0061626 name: pharyngeal arch artery morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914] synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph] is_a: GO:0048844 ! artery morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery relationship: BFO:0000050 GO:0060037 ! part of pharyngeal system development relationship: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery creation_date: 2014-05-09T15:34:06Z [Term] id: GO:0061629 name: RNA polymerase II-specific DNA-binding transcription factor binding namespace: molecular_function def: "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] synonym: "RNA polymerase II activating transcription factor binding" RELATED [] synonym: "RNA polymerase II repressing transcription factor binding" RELATED [] synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT [] synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT [] synonym: "RNA polymerase II transcription factor binding" RELATED [] is_a: GO:0140297 ! DNA-binding transcription factor binding creation_date: 2014-05-15T09:12:24Z [Term] id: GO:0061650 name: ubiquitin-like protein conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" BROAD [] synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:15:27Z [Term] id: GO:0061651 name: Atg12 conjugating enzyme activity namespace: molecular_function def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph] synonym: "E2" BROAD [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity created_by: dph creation_date: 2014-11-06T13:17:36Z [Term] id: GO:0061659 name: ubiquitin-like protein ligase activity namespace: molecular_function def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity created_by: dph creation_date: 2014-11-06T13:46:23Z [Term] id: GO:0061660 name: Atg12 ligase activity namespace: molecular_function def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" BROAD [GOC:dph] is_a: GO:0019777 ! Atg12 transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity created_by: dph creation_date: 2014-11-06T13:50:42Z [Term] id: GO:0061668 name: mitochondrial ribosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph] is_a: GO:0042255 ! ribosome assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005761 ! results in assembly of mitochondrial ribosome relationship: RO:0002588 GO:0005761 ! results in assembly of mitochondrial ribosome creation_date: 2014-11-07T15:32:20Z [Term] id: GO:0061725 name: cytosolic lipolysis namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy] is_a: GO:0016042 ! lipid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: BFO:0000066 GO:0005829 ! occurs in cytosol creation_date: 2015-07-08T13:42:15Z [Term] id: GO:0061736 name: engulfment of target by autophagosome namespace: biological_process def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL] is_a: GO:0010324 ! membrane invagination intersection_of: GO:0010324 ! membrane invagination intersection_of: BFO:0000050 GO:0000045 ! part of autophagosome assembly relationship: BFO:0000050 GO:0000045 ! part of autophagosome assembly created_by: dph creation_date: 2015-09-14T14:10:24Z [Term] id: GO:0061792 name: secretory granule maturation namespace: biological_process def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] is_a: GO:0033363 ! secretory granule organization is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 GO:0030141 ! results in maturation of secretory granule relationship: RO:0002299 GO:0030141 ! results in maturation of secretory granule creation_date: 2016-09-09T13:24:34Z [Term] id: GO:0061853 name: regulation of neuroblast migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097402 ! regulates neuroblast migration relationship: RO:0002211 GO:0097402 ! regulates neuroblast migration creation_date: 2017-03-08T18:17:07Z [Term] id: GO:0061854 name: positive regulation of neuroblast migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0061853 ! regulation of neuroblast migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097402 ! positively regulates neuroblast migration relationship: RO:0002213 GO:0097402 ! positively regulates neuroblast migration creation_date: 2017-03-08T18:22:30Z [Term] id: GO:0061855 name: negative regulation of neuroblast migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0061853 ! regulation of neuroblast migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097402 ! negatively regulates neuroblast migration relationship: RO:0002212 GO:0097402 ! negatively regulates neuroblast migration creation_date: 2017-03-08T18:26:21Z [Term] id: GO:0061880 name: regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098957 ! regulates anterograde axonal transport of mitochondrion relationship: RO:0002211 GO:0098957 ! regulates anterograde axonal transport of mitochondrion creation_date: 2017-05-30T14:15:46Z [Term] id: GO:0061881 name: positive regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "positive regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098957 ! positively regulates anterograde axonal transport of mitochondrion relationship: RO:0002213 GO:0098957 ! positively regulates anterograde axonal transport of mitochondrion creation_date: 2017-05-30T14:21:08Z [Term] id: GO:0061882 name: negative regulation of anterograde axonal transport of mitochondrion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] synonym: "negative regulation of anterograde axon transport of mitochondria" EXACT [] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098957 ! negatively regulates anterograde axonal transport of mitochondrion relationship: RO:0002212 GO:0098957 ! negatively regulates anterograde axonal transport of mitochondrion creation_date: 2017-05-30T14:25:16Z [Term] id: GO:0061888 name: regulation of astrocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048710 ! regulation of astrocyte differentiation is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048143 ! regulates astrocyte activation relationship: RO:0002211 GO:0048143 ! regulates astrocyte activation creation_date: 2017-06-01T22:26:29Z [Term] id: GO:0061889 name: negative regulation of astrocyte activation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048712 ! negative regulation of astrocyte differentiation is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:0061888 ! regulation of astrocyte activation is_a: GO:0150079 ! negative regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048143 ! negatively regulates astrocyte activation relationship: RO:0002212 GO:0048143 ! negatively regulates astrocyte activation creation_date: 2017-06-01T22:29:43Z [Term] id: GO:0061890 name: positive regulation of astrocyte activation namespace: biological_process def: "Any process that increases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] is_a: GO:0048711 ! positive regulation of astrocyte differentiation is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:0061888 ! regulation of astrocyte activation is_a: GO:0150078 ! positive regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048143 ! positively regulates astrocyte activation relationship: RO:0002213 GO:0048143 ! positively regulates astrocyte activation creation_date: 2017-06-01T22:31:50Z [Term] id: GO:0061900 name: glial cell activation namespace: biological_process def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082] is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000125 ! has primary input glial cell relationship: BFO:0000050 GO:0150076 ! part of neuroinflammatory response relationship: RO:0004009 CL:0000125 ! has primary input glial cell creation_date: 2017-06-13T13:06:23Z [Term] id: GO:0061919 name: process utilizing autophagic mechanism namespace: biological_process def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process created_by: dph creation_date: 2017-07-13T19:42:14Z [Term] id: GO:0061938 name: protein localization to somatodendritic compartment namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993] synonym: "somatodendritic protein localization" EXACT [] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment relationship: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment creation_date: 2017-09-08T13:22:26Z [Term] id: GO:0061951 name: establishment of protein localization to plasma membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw] is_a: GO:0072659 ! protein localization to plasma membrane is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane created_by: dph creation_date: 2017-10-26T12:55:15Z [Term] id: GO:0061971 name: replacement bone morphogenesis namespace: biological_process def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [PMID:29852585] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone relationship: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone creation_date: 2018-02-12T18:10:59Z [Term] id: GO:0061972 name: dermal bone morphogenesis namespace: biological_process def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632] is_a: GO:0061973 ! membrane bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone relationship: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone creation_date: 2018-02-12T18:16:21Z [Term] id: GO:0061973 name: membrane bone morphogenesis namespace: biological_process def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone relationship: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone creation_date: 2018-02-12T18:21:09Z [Term] id: GO:0061982 name: meiosis I cell cycle process namespace: biological_process def: "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397] synonym: "first meiotic cell division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:27:20Z [Term] id: GO:0061983 name: meiosis II cell cycle process namespace: biological_process def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397] synonym: "second meiotic division" EXACT [PMID:29385397] is_a: GO:1903046 ! meiotic cell cycle process created_by: dph creation_date: 2018-02-14T22:37:44Z [Term] id: GO:0062012 name: regulation of small molecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] synonym: "regulation of small molecule metabolism" EXACT [] xref: Reactome:R-HSA-9861718 "Regulation of pyruvate metabolism" is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044281 ! regulates small molecule metabolic process relationship: RO:0002211 GO:0044281 ! regulates small molecule metabolic process created_by: dph creation_date: 2018-03-19T14:11:54Z [Term] id: GO:0062013 name: positive regulation of small molecule metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "positive regulation of small molecule metabolism" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process relationship: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process creation_date: 2018-03-19T14:25:10Z [Term] id: GO:0062014 name: negative regulation of small molecule metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] synonym: "negative regulation of small molecule metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process relationship: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process creation_date: 2018-03-19T14:27:23Z [Term] id: GO:0062033 name: positive regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation relationship: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation creation_date: 2018-04-23T14:32:23Z [Term] id: GO:0062125 name: regulation of mitochondrial gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [PMID:28285835] is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression relationship: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression creation_date: 2019-05-30T16:45:04Z [Term] id: GO:0062149 name: detection of stimulus involved in sensory perception of pain namespace: biological_process def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031] is_a: GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: GO:0051606 ! detection of stimulus intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain relationship: BFO:0000050 GO:0019233 ! part of sensory perception of pain creation_date: 2019-09-13T13:48:47Z [Term] id: GO:0062197 name: cellular response to chemical stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] xref: Reactome:R-HSA-9711123 "Cellular response to chemical stress" is_a: GO:0033554 ! cellular response to stress is_a: GO:0070887 ! cellular response to chemical stimulus creation_date: 2019-12-10T14:42:03Z [Term] id: GO:0062237 name: protein localization to postsynapse namespace: biological_process def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse relationship: RO:0002339 GO:0098794 ! has target end location postsynapse creation_date: 2020-04-20T13:58:43Z [Term] id: GO:0062247 name: chloroplast vesicle namespace: cellular_component def: "A intracellular vesicle that is part of a chloroplast." [PMID:32245810] is_a: GO:0031410 ! cytoplasmic vesicle intersection_of: GO:0097708 ! intracellular vesicle intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast relationship: BFO:0000050 GO:0009507 ! part of chloroplast creation_date: 2020-05-01T12:10:16Z [Term] id: GO:0065002 name: intracellular protein transmembrane transport namespace: biological_process def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "intracellular membrane translocation of a protein" EXACT [] synonym: "intracellular protein membrane transport" EXACT [] synonym: "intracellular protein transport across a membrane" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0071806 ! protein transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 alt_id: GO:0034622 alt_id: GO:0043623 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_prokaryote synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] synonym: "cellular protein-containing complex assembly" RELATED [] synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex relationship: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gocheck_obsoletion_candidate subset: goslim_pir subset: goslim_plant synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003674 ! regulates molecular_function relationship: RO:0002211 GO:0003674 ! regulates molecular_function [Term] id: GO:0065010 name: extracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] synonym: "extracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043230 ! extracellular organelle intersection_of: GO:0043227 ! membrane-bounded organelle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0043229 ! part of intracellular organelle relationship: BFO:0000050 GO:0043229 ! part of intracellular organelle [Term] id: GO:0070050 name: neuron cellular homeostasis namespace: biological_process def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] synonym: "neuron maintenance" EXACT [] is_a: GO:0019725 ! cellular homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron relationship: BFO:0000066 CL:0000540 ! occurs in neuron [Term] id: GO:0070051 name: fibrinogen binding namespace: molecular_function def: "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk] is_a: GO:0044877 ! protein-containing complex binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005577 ! has primary input fibrinogen complex relationship: RO:0004009 GO:0005577 ! has primary input fibrinogen complex [Term] id: GO:0070062 name: extracellular exosome namespace: cellular_component def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] synonym: "exosome" EXACT [GOC:pr] synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles] is_a: GO:1903561 ! extracellular vesicle relationship: BFO:0000050 GO:0005615 ! part of extracellular space [Term] id: GO:0070124 name: mitochondrial translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah] synonym: "mitochondrial translation initiation" EXACT [GOC:mah] xref: Reactome:R-HSA-5368286 "Mitochondrial translation initiation" is_a: GO:0006413 ! translational initiation intersection_of: GO:0006413 ! translational initiation intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation [Term] id: GO:0070125 name: mitochondrial translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] synonym: "mitochondrial translation elongation" EXACT [GOC:mah] xref: Reactome:R-HSA-5389840 "Mitochondrial translation elongation" is_a: GO:0006414 ! translational elongation intersection_of: GO:0006414 ! translational elongation intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation [Term] id: GO:0070126 name: mitochondrial translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria] synonym: "mitochondrial translation termination" EXACT [GOC:mah] xref: Reactome:R-HSA-5419276 "Mitochondrial translation termination" is_a: GO:0006415 ! translational termination intersection_of: GO:0006415 ! translational termination intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation [Term] id: GO:0070129 name: regulation of mitochondrial translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0006417 ! regulation of translation is_a: GO:0062125 ! regulation of mitochondrial gene expression intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032543 ! regulates mitochondrial translation relationship: RO:0002211 GO:0032543 ! regulates mitochondrial translation [Term] id: GO:0070130 name: negative regulation of mitochondrial translation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032543 ! negatively regulates mitochondrial translation relationship: RO:0002212 GO:0032543 ! negatively regulates mitochondrial translation [Term] id: GO:0070131 name: positive regulation of mitochondrial translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah] synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah] is_a: GO:0045727 ! positive regulation of translation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation relationship: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation [Term] id: GO:0070132 name: regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0070129 ! regulation of mitochondrial translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070124 ! regulates mitochondrial translational initiation relationship: RO:0002211 GO:0070124 ! regulates mitochondrial translational initiation [Term] id: GO:0070133 name: negative regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:0070132 ! regulation of mitochondrial translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070124 ! negatively regulates mitochondrial translational initiation relationship: RO:0002212 GO:0070124 ! negatively regulates mitochondrial translational initiation [Term] id: GO:0070134 name: positive regulation of mitochondrial translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:0070131 ! positive regulation of mitochondrial translation is_a: GO:0070132 ! regulation of mitochondrial translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070124 ! positively regulates mitochondrial translational initiation relationship: RO:0002213 GO:0070124 ! positively regulates mitochondrial translational initiation [Term] id: GO:0070160 name: tight junction namespace: cellular_component def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] synonym: "occluding cell junction" EXACT [GOC:mah] synonym: "occluding junction" EXACT [GOC:mah] xref: Wikipedia:Tight_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0070161 name: anchoring junction namespace: cellular_component def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] synonym: "anchoring cell junction" EXACT [GOC:mah] is_a: GO:0030054 ! cell junction [Term] id: GO:0070192 name: chromosome organization involved in meiotic cell cycle namespace: biological_process def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle [Term] id: GO:0070199 name: establishment of protein localization to chromosome namespace: biological_process def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome [Term] id: GO:0070201 name: regulation of establishment of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045184 ! regulates establishment of protein localization relationship: RO:0002211 GO:0045184 ! regulates establishment of protein localization [Term] id: GO:0070202 name: regulation of establishment of protein localization to chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome relationship: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome [Term] id: GO:0070227 name: lymphocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "lymphocyte apoptosis" NARROW [] is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte [Term] id: GO:0070228 name: regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "regulation of lymphocyte apoptosis" NARROW [] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070227 ! regulates lymphocyte apoptotic process relationship: RO:0002211 GO:0070227 ! regulates lymphocyte apoptotic process [Term] id: GO:0070229 name: negative regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add] synonym: "negative regulation of lymphocyte apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070227 ! negatively regulates lymphocyte apoptotic process relationship: RO:0002212 GO:0070227 ! negatively regulates lymphocyte apoptotic process [Term] id: GO:0070230 name: positive regulation of lymphocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "positive regulation of lymphocyte apoptosis" NARROW [] synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add] synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add] synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070227 ! positively regulates lymphocyte apoptotic process relationship: RO:0002213 GO:0070227 ! positively regulates lymphocyte apoptotic process [Term] id: GO:0070231 name: T cell apoptotic process namespace: biological_process def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "T cell apoptosis" NARROW [] synonym: "T lymphocyte apoptosis" EXACT [GOC:add] synonym: "T-cell apoptosis" EXACT [GOC:add] synonym: "T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070227 ! lymphocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0070232 name: regulation of T cell apoptotic process namespace: biological_process def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "regulation of T cell apoptosis" NARROW [] synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070231 ! regulates T cell apoptotic process relationship: RO:0002211 GO:0070231 ! regulates T cell apoptotic process [Term] id: GO:0070233 name: negative regulation of T cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "down regulation of T cell apoptosis" EXACT [GOC:add] synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "downregulation of T cell apoptosis" EXACT [GOC:add] synonym: "inhibition of T cell apoptosis" NARROW [GOC:add] synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "negative regulation of T cell apoptosis" NARROW [] synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add] is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070231 ! negatively regulates T cell apoptotic process relationship: RO:0002212 GO:0070231 ! negatively regulates T cell apoptotic process [Term] id: GO:0070234 name: positive regulation of T cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] synonym: "activation of T cell apoptosis" NARROW [GOC:add] synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] synonym: "positive regulation of T cell apoptosis" NARROW [] synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add] synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add] synonym: "stimulation of T cell apoptosis" NARROW [GOC:add] synonym: "up regulation of T cell apoptosis" EXACT [GOC:add] synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add] synonym: "upregulation of T cell apoptosis" EXACT [GOC:add] is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process is_a: GO:0070232 ! regulation of T cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070231 ! positively regulates T cell apoptotic process relationship: RO:0002213 GO:0070231 ! positively regulates T cell apoptotic process [Term] id: GO:0070265 name: obsolete necrotic cell death namespace: biological_process def: "OBSOLETE. A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910] comment: The reason for obsoletion is that this term represent an assay and not a GO process.\n The reason for obsoletion is that this represents a phenotype. synonym: "cellular necrosis" EXACT [GOC:add] synonym: "necrosis" BROAD [GOC:mah] [Term] id: GO:0070278 name: extracellular matrix constituent secretion namespace: biological_process def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] synonym: "ECM constituent secretion" EXACT [GOC:mah] synonym: "ECM secretion" EXACT [GOC:mah] is_a: GO:0032940 ! secretion by cell relationship: BFO:0000050 GO:0030198 ! part of extracellular matrix organization [Term] id: GO:0070285 name: pigment cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000147 ! results in development of pigment cell relationship: BFO:0000050 GO:0050931 ! part of pigment cell differentiation relationship: RO:0002296 CL:0000147 ! results in development of pigment cell [Term] id: GO:0070341 name: fat cell proliferation namespace: biological_process def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] synonym: "adipocyte proliferation" EXACT [GOC:sl] synonym: "adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000136 ! acts on population of adipocyte relationship: RO:0012003 CL:0000136 ! acts on population of adipocyte [Term] id: GO:0070344 name: regulation of fat cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070341 ! regulates fat cell proliferation relationship: RO:0002211 GO:0070341 ! regulates fat cell proliferation [Term] id: GO:0070345 name: negative regulation of fat cell proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah] synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah] synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation relationship: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation [Term] id: GO:0070346 name: positive regulation of fat cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] synonym: "activation of fat cell proliferation" NARROW [GOC:mah] synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl] synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl] synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah] synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah] synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070344 ! regulation of fat cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation relationship: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle is_a: GO:0099503 ! secretory vesicle intersection_of: GO:0030133 ! transport vesicle intersection_of: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane [Term] id: GO:0070444 name: oligodendrocyte progenitor proliferation namespace: biological_process def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915] synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0061351 ! neural precursor cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0002453 ! acts on population of oligodendrocyte precursor cell relationship: BFO:0000050 GO:0042063 ! part of gliogenesis relationship: RO:0012003 CL:0002453 ! acts on population of oligodendrocyte precursor cell [Term] id: GO:0070445 name: regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070444 ! regulates oligodendrocyte progenitor proliferation relationship: RO:0002211 GO:0070444 ! regulates oligodendrocyte progenitor proliferation [Term] id: GO:0070446 name: negative regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014014 ! negative regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070444 ! negatively regulates oligodendrocyte progenitor proliferation relationship: RO:0002212 GO:0070444 ! negatively regulates oligodendrocyte progenitor proliferation [Term] id: GO:0070447 name: positive regulation of oligodendrocyte progenitor proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] is_a: GO:0014015 ! positive regulation of gliogenesis is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070444 ! positively regulates oligodendrocyte progenitor proliferation relationship: RO:0002213 GO:0070444 ! positively regulates oligodendrocyte progenitor proliferation [Term] id: GO:0070459 name: prolactin secretion namespace: biological_process def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion intersection_of: RO:0004009 PR:000013246 ! has primary input prolactin relationship: RO:0004009 PR:000013246 ! has primary input prolactin [Term] id: GO:0070482 name: response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0070483 name: detection of hypoxia namespace: biological_process def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] is_a: GO:0001666 ! response to hypoxia is_a: GO:0003032 ! detection of oxygen [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0032886 ! regulation of microtubule-based process is_a: GO:0051493 ! regulation of cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization relationship: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization [Term] id: GO:0070585 name: protein localization to mitochondrion namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] synonym: "protein localisation in mitochondrion" EXACT [GOC:mah] synonym: "protein localization in mitochondrion" EXACT [] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005739 ! has target end location mitochondrion relationship: RO:0002339 GO:0005739 ! has target end location mitochondrion creation_date: 2009-04-24T02:31:18Z [Term] id: GO:0070633 name: transepithelial transport namespace: biological_process def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithelium relationship: RO:0002342 UBERON:0000483 ! results in transport across epithelium creation_date: 2009-05-06T03:31:02Z [Term] id: GO:0070661 name: leukocyte proliferation namespace: biological_process def: "The expansion of a leukocyte population by cell division." [GOC:add] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte creation_date: 2009-05-28T05:25:28Z [Term] id: GO:0070663 name: regulation of leukocyte proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070661 ! regulates leukocyte proliferation relationship: RO:0002211 GO:0070661 ! regulates leukocyte proliferation creation_date: 2009-05-28T05:30:39Z [Term] id: GO:0070664 name: negative regulation of leukocyte proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation relationship: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation creation_date: 2009-05-28T05:34:50Z [Term] id: GO:0070665 name: positive regulation of leukocyte proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] synonym: "activation of leukocyte proliferation" NARROW [GOC:mah] synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah] synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah] synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation relationship: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation creation_date: 2009-05-28T05:36:46Z [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization created_by: mah creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070830 name: bicellular tight junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah] synonym: "tight junction formation" EXACT [GOC:mah] xref: Reactome:R-HSA-420029 "Tight junction interactions" is_a: GO:0120192 ! tight junction assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005923 ! results in assembly of bicellular tight junction relationship: BFO:0000050 GO:0043297 ! part of apical junction assembly relationship: RO:0002588 GO:0005923 ! results in assembly of bicellular tight junction creation_date: 2009-07-23T04:32:38Z [Term] id: GO:0070831 name: basement membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah] comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. is_a: GO:0071711 ! basement membrane organization is_a: GO:0085029 ! extracellular matrix assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005604 ! results in assembly of basement membrane relationship: RO:0002588 GO:0005604 ! results in assembly of basement membrane creation_date: 2009-07-23T05:01:51Z [Term] id: GO:0070851 name: growth factor receptor binding namespace: molecular_function def: "Binding to a growth factor receptor." [GOC:mah, GOC:vw] is_a: GO:0005102 ! signaling receptor binding creation_date: 2009-08-07T11:23:02Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043226 ! results in assembly of organelle relationship: RO:0002588 GO:0043226 ! results in assembly of organelle created_by: mah creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0070977 name: bone maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] is_a: GO:0048799 ! animal organ maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001474 ! results in maturation of bone element relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002299 UBERON:0001474 ! results in maturation of bone element creation_date: 2009-10-05T04:35:31Z [Term] id: GO:0071168 name: protein localization to chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin creation_date: 2009-11-20T11:51:20Z [Term] id: GO:0071169 name: establishment of protein localization to chromatin namespace: biological_process def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0070199 ! establishment of protein localization to chromosome is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin creation_date: 2009-11-20T11:52:43Z [Term] id: GO:0071229 name: cellular response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. subset: gocheck_do_not_annotate synonym: "cellular response to acid" BROAD [] synonym: "cellular response to acid anion" RELATED [] synonym: "cellular response to oxoanion" RELATED [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0070887 ! cellular response to chemical stimulus creation_date: 2009-12-03T02:07:23Z [Term] id: GO:0071230 name: cellular response to amino acid stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah] synonym: "cellular response to amino acid" EXACT [GOC:mah] is_a: GO:0043200 ! response to amino acid is_a: GO:0071229 ! cellular response to acid chemical intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion creation_date: 2009-12-03T02:08:11Z [Term] id: GO:0071322 name: cellular response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate creation_date: 2009-12-10T05:13:33Z [Term] id: GO:0071345 name: cellular response to cytokine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] xref: Reactome:R-HSA-9007892 "Interleukin-38 signaling" xref: Reactome:R-HSA-9008059 "Interleukin-37 signaling" is_a: GO:0034097 ! response to cytokine creation_date: 2009-12-11T02:41:12Z [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25905 ! has primary input creation_date: 2009-12-11T03:24:18Z [Term] id: GO:0071383 name: cellular response to steroid hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] xref: Reactome:R-HSA-3371497 "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0048545 ! response to steroid hormone is_a: GO:0071396 ! cellular response to lipid intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:26764 ! has primary input creation_date: 2009-12-11T03:49:02Z [Term] id: GO:0071396 name: cellular response to lipid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] is_a: GO:0033993 ! response to lipid is_a: GO:0070887 ! cellular response to chemical stimulus intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid creation_date: 2009-12-11T04:37:10Z [Term] id: GO:0071418 name: cellular response to amine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] is_a: GO:0014075 ! response to amine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine creation_date: 2009-12-14T04:08:17Z [Term] id: GO:0071425 name: hematopoietic stem cell proliferation namespace: biological_process def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl] synonym: "hemopoietic stem cell proliferation" EXACT [] is_a: GO:0072089 ! stem cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell creation_date: 2009-12-16T10:22:52Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate xref: Reactome:R-HSA-9860931 "Response of endothelial cells to shear stress" is_a: GO:0009719 ! response to endogenous stimulus creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process alt_id: GO:0070882 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_chembl subset: goslim_euk_cellular_processes_ribbon subset: goslim_generic subset: goslim_pombe subset: goslim_prokaryote subset: goslim_prokaryote_ribbon subset: goslim_yeast synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular cell wall organization or biogenesis" EXACT [] is_a: GO:0009987 ! cellular process created_by: mah creation_date: 2010-01-13T03:19:38Z [Term] id: GO:0071555 name: cell wall organization namespace: biological_process alt_id: GO:0007047 alt_id: GO:0044234 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] subset: goslim_candida subset: goslim_pir synonym: "cell wall organisation" EXACT [] synonym: "cell wall organisation in other organism" EXACT [GOC:mah] synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cell wall organization in other organism" EXACT [] synonym: "cellular cell wall organisation" EXACT [] synonym: "cellular cell wall organization" EXACT [] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0071554 ! cell wall organization or biogenesis created_by: mah creation_date: 2010-01-13T03:33:07Z [Term] id: GO:0071621 name: granulocyte chemotaxis namespace: biological_process def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097530 ! granulocyte migration intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000094 ! results in movement of granulocyte creation_date: 2010-02-09T04:08:17Z [Term] id: GO:0071622 name: regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002688 ! regulation of leukocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071621 ! regulates granulocyte chemotaxis relationship: RO:0002211 GO:0071621 ! regulates granulocyte chemotaxis creation_date: 2010-02-09T04:09:24Z [Term] id: GO:0071623 name: negative regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071621 ! negatively regulates granulocyte chemotaxis relationship: RO:0002212 GO:0071621 ! negatively regulates granulocyte chemotaxis creation_date: 2010-02-09T04:13:19Z [Term] id: GO:0071624 name: positive regulation of granulocyte chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071621 ! positively regulates granulocyte chemotaxis relationship: RO:0002213 GO:0071621 ! positively regulates granulocyte chemotaxis creation_date: 2010-02-09T04:15:36Z [Term] id: GO:0071626 name: mastication namespace: biological_process def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg] synonym: "chewing" EXACT [GOC:mah] is_a: GO:0022600 ! digestive system process creation_date: 2010-02-10T11:19:48Z [Term] id: GO:0071670 name: smooth muscle cell chemotaxis namespace: biological_process def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah] is_a: GO:0014909 ! smooth muscle cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell creation_date: 2010-02-16T01:32:59Z [Term] id: GO:0071671 name: regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071670 ! regulates smooth muscle cell chemotaxis relationship: RO:0002211 GO:0071670 ! regulates smooth muscle cell chemotaxis creation_date: 2010-02-16T01:42:03Z [Term] id: GO:0071672 name: negative regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071670 ! negatively regulates smooth muscle cell chemotaxis relationship: RO:0002212 GO:0071670 ! negatively regulates smooth muscle cell chemotaxis creation_date: 2010-02-16T01:44:28Z [Term] id: GO:0071673 name: positive regulation of smooth muscle cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah] synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071670 ! positively regulates smooth muscle cell chemotaxis relationship: RO:0002213 GO:0071670 ! positively regulates smooth muscle cell chemotaxis creation_date: 2010-02-16T01:48:14Z [Term] id: GO:0071674 name: mononuclear cell migration namespace: biological_process def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000842 ! results in movement of mononuclear leukocyte relationship: RO:0002565 CL:0000842 ! results in movement of mononuclear leukocyte creation_date: 2010-02-16T02:11:00Z [Term] id: GO:0071675 name: regulation of mononuclear cell migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071674 ! regulates mononuclear cell migration relationship: RO:0002211 GO:0071674 ! regulates mononuclear cell migration creation_date: 2010-02-16T02:11:53Z [Term] id: GO:0071676 name: negative regulation of mononuclear cell migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071674 ! negatively regulates mononuclear cell migration relationship: RO:0002212 GO:0071674 ! negatively regulates mononuclear cell migration creation_date: 2010-02-16T02:13:55Z [Term] id: GO:0071677 name: positive regulation of mononuclear cell migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] synonym: "activation of mononuclear cell migration" NARROW [GOC:mah] synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah] synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah] synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071674 ! positively regulates mononuclear cell migration relationship: RO:0002213 GO:0071674 ! positively regulates mononuclear cell migration creation_date: 2010-02-16T02:15:29Z [Term] id: GO:0071692 name: protein localization to extracellular region namespace: biological_process def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] synonym: "protein localisation in extracellular region" EXACT [GOC:mah] synonym: "protein localization in extracellular region" EXACT [] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: GO:0033036 ! macromolecule localization intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0002339 GO:0005576 ! has target end location extracellular region created_by: mah creation_date: 2010-02-25T04:00:13Z [Term] id: GO:0071695 name: anatomical structure maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: GO:0021700 ! developmental maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development relationship: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure creation_date: 2010-03-02T11:43:38Z [Term] id: GO:0071696 name: ectodermal placode development namespace: biological_process def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode relationship: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode creation_date: 2010-03-02T11:48:01Z [Term] id: GO:0071697 name: ectodermal placode morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode relationship: BFO:0000050 GO:0071696 ! part of ectodermal placode development relationship: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode creation_date: 2010-03-02T11:49:51Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gocheck_obsoletion_candidate is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity created_by: mah creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061024 ! membrane organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0016020 ! results in assembly of membrane relationship: BFO:0000050 GO:0044091 ! part of membrane biogenesis relationship: RO:0002588 GO:0016020 ! results in assembly of membrane created_by: mah creation_date: 2010-03-10T11:19:17Z [Term] id: GO:0071711 name: basement membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. synonym: "basement membrane organisation" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005604 ! results in organization of basement membrane relationship: RO:0002592 GO:0005604 ! results in organization of basement membrane creation_date: 2010-03-10T11:57:10Z [Term] id: GO:0071763 name: nuclear membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] synonym: "nuclear membrane organisation" EXACT [GOC:mah] synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0031965 ! results in organization of nuclear membrane relationship: BFO:0000050 GO:0006998 ! part of nuclear envelope organization relationship: RO:0002592 GO:0031965 ! results in organization of nuclear membrane created_by: mah creation_date: 2010-03-29T03:59:35Z [Term] id: GO:0071764 name: nuclear outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah] synonym: "nuclear outer membrane organisation" EXACT [GOC:mah] synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071763 ! nuclear membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane relationship: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane creation_date: 2010-03-29T04:03:37Z [Term] id: GO:0071806 name: protein transmembrane transport namespace: biological_process def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "protein membrane transport" EXACT [] is_a: GO:0015031 ! protein transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein creation_date: 2010-09-03T02:54:26Z [Term] id: GO:0071826 name: protein-RNA complex organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organization" EXACT [] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex relationship: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex created_by: mah creation_date: 2010-09-08T10:10:35Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon subset: goslim_metagenomics synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0009987 ! cellular process created_by: mah creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071867 name: response to monoamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] synonym: "response to monoamine stimulus" EXACT [GOC:dos] is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:63534 ! has primary input relationship: RO:0004009 CHEBI:63534 ! has primary input creation_date: 2010-09-13T02:36:37Z [Term] id: GO:0071868 name: cellular response to monoamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] is_a: GO:0071867 ! response to monoamine is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:63534 ! has primary input creation_date: 2010-09-13T02:38:52Z [Term] id: GO:0071869 name: response to catecholamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] synonym: "response to catecholamine stimulus" EXACT [GOC:dos] is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2010-09-13T02:51:13Z [Term] id: GO:0071870 name: cellular response to catecholamine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:0071869 ! response to catecholamine is_a: GO:1901701 ! cellular response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2010-09-13T02:54:50Z [Term] id: GO:0071873 name: response to norepinephrine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] synonym: "response to norepinephrine stimulus" EXACT [GOC:dos] is_a: GO:0071869 ! response to catecholamine intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:72587 ! has primary input relationship: RO:0004009 CHEBI:72587 ! has primary input creation_date: 2010-09-13T03:31:53Z [Term] id: GO:0071874 name: cellular response to norepinephrine stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071873 ! response to norepinephrine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:72587 ! has primary input creation_date: 2010-09-13T03:33:32Z [Term] id: GO:0071887 name: leukocyte apoptotic process namespace: biological_process def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "leukocyte apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: BFO:0000066 CL:0000738 ! occurs in leukocyte relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata creation_date: 2010-09-14T12:44:09Z [Term] id: GO:0071888 name: macrophage apoptotic process namespace: biological_process def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). synonym: "activation-induced cell death" RELATED [GOC:yaf] synonym: "AICD" RELATED [GOC:yaf] synonym: "macrophage apoptosis" NARROW [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage relationship: BFO:0000066 CL:0000235 ! occurs in macrophage creation_date: 2010-09-14T12:50:40Z [Term] id: GO:0071897 name: DNA biosynthetic process namespace: biological_process def: "The biosynthetic process resulting in the formation of DNA." [GOC:mah] synonym: "DNA anabolism" EXACT [GOC:mah] synonym: "DNA biosynthesis" EXACT [GOC:mah] synonym: "DNA formation" EXACT [GOC:mah] synonym: "DNA synthesis" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0141187 ! nucleic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:16991 ! has primary output relationship: RO:0004008 CHEBI:16991 ! has primary output creation_date: 2010-09-15T02:14:33Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt] subset: goslim_flybase_ribbon is_a: GO:0110165 ! cellular anatomical structure created_by: mah creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0071953 name: elastic fiber namespace: cellular_component def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620] synonym: "elastic fibre" EXACT [GOC:mah] synonym: "elastin fiber" EXACT [GOC:BHF] is_a: GO:0099512 ! supramolecular fiber relationship: BFO:0000050 GO:0031012 ! part of extracellular matrix creation_date: 2010-10-11T11:44:57Z [Term] id: GO:0071971 name: extracellular exosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458] synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome relationship: BFO:0000050 GO:0097734 ! part of extracellular exosome biogenesis relationship: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome creation_date: 2010-10-18T03:44:18Z [Term] id: GO:0072089 name: stem cell proliferation namespace: biological_process def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000034 ! acts on population of stem cell relationship: BFO:0000051 GO:0017145 ! has part stem cell division relationship: RO:0012003 CL:0000034 ! acts on population of stem cell creation_date: 2010-02-08T02:03:36Z [Term] id: GO:0072091 name: regulation of stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072089 ! regulates stem cell proliferation relationship: RO:0002211 GO:0072089 ! regulates stem cell proliferation creation_date: 2010-02-08T02:09:03Z [Term] id: GO:0072132 name: mesenchyme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis relationship: BFO:0000050 GO:0060485 ! part of mesenchyme development relationship: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme creation_date: 2010-02-22T02:17:15Z [Term] id: GO:0072175 name: epithelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] is_a: GO:0035148 ! tube formation intersection_of: GO:0035148 ! tube formation intersection_of: RO:0002297 UBERON:0003914 ! results in formation of epithelial tube relationship: BFO:0000050 GO:0060562 ! part of epithelial tube morphogenesis relationship: RO:0002297 UBERON:0003914 ! results in formation of epithelial tube creation_date: 2010-02-26T02:15:40Z [Term] id: GO:0072201 name: negative regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation relationship: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation creation_date: 2010-03-01T03:43:29Z [Term] id: GO:0072329 name: monocarboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion creation_date: 2010-11-02T04:41:55Z [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "monocarboxylic acid formation" EXACT [GOC:mah] synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:35757 ! has primary output monocarboxylic acid anion relationship: RO:0004008 CHEBI:35757 ! has primary output monocarboxylic acid anion creation_date: 2010-11-02T04:51:32Z [Term] id: GO:0072359 name: circulatory system development namespace: biological_process def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] subset: goslim_drosophila synonym: "cardiovascular system development" NARROW [] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001009 ! results in development of circulatory system relationship: RO:0002296 UBERON:0001009 ! results in development of circulatory system creation_date: 2010-11-16T11:27:39Z [Term] id: GO:0072360 name: vascular cord development namespace: biological_process def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0006965 ! results in development of vascular cord relationship: BFO:0000050 GO:0072359 ! part of circulatory system development relationship: RO:0002296 UBERON:0006965 ! results in development of vascular cord creation_date: 2010-11-16T11:46:55Z [Term] id: GO:0072384 name: organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! transport along microtubule is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0043226 ! has primary input organelle creation_date: 2010-12-01T04:59:11Z [Term] id: GO:0072537 name: fibroblast activation namespace: biological_process def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah] is_a: GO:0001775 ! cell activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000057 ! has primary input fibroblast relationship: RO:0004009 CL:0000057 ! has primary input fibroblast creation_date: 2011-01-14T04:35:08Z [Term] id: GO:0072577 name: endothelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "apoptosis of endothelial cells" EXACT [GOC:mah] synonym: "endothelial cell apoptosis" NARROW [] synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah] synonym: "killing of endothelial cells" EXACT [GOC:mah] synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah] synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000115 ! occurs in endothelial cell relationship: BFO:0000066 CL:0000115 ! occurs in endothelial cell creation_date: 2011-02-02T03:56:24Z [Term] id: GO:0072592 name: oxygen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah] synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] synonym: "oxygen metabolism" EXACT [GOC:mah] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:15379 ! has primary input or output relationship: RO:0004007 CHEBI:15379 ! has primary input or output creation_date: 2011-02-11T10:46:51Z [Term] id: GO:0072593 name: reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah] synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:26523 ! has primary input or output reactive oxygen species relationship: RO:0004007 CHEBI:26523 ! has primary input or output reactive oxygen species created_by: mah creation_date: 2011-02-11T10:50:06Z [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle is_a: GO:0045184 ! establishment of protein localization intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0043226 ! has target end location organelle created_by: mah creation_date: 2011-02-14T01:56:51Z [Term] id: GO:0072595 name: maintenance of protein localization in organelle namespace: biological_process def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah] synonym: "maintenance of protein localization to organelle" EXACT [] is_a: GO:0032507 ! maintenance of protein location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0043226 ! occurs in organelle relationship: BFO:0000050 GO:0033365 ! part of protein localization to organelle relationship: BFO:0000066 GO:0043226 ! occurs in organelle creation_date: 2011-02-14T02:09:13Z [Term] id: GO:0072596 name: establishment of protein localization to chloroplast namespace: biological_process def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah] synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072598 ! protein localization to chloroplast intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0009507 ! has target end location chloroplast creation_date: 2011-02-14T02:16:13Z [Term] id: GO:0072597 name: maintenance of protein location in chloroplast namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0009507 ! occurs in chloroplast relationship: BFO:0000050 GO:0072598 ! part of protein localization to chloroplast relationship: BFO:0000066 GO:0009507 ! occurs in chloroplast creation_date: 2011-02-14T02:17:48Z [Term] id: GO:0072598 name: protein localization to chloroplast namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd] synonym: "protein localisation to chloroplast" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0009507 ! has target end location chloroplast relationship: RO:0002339 GO:0009507 ! has target end location chloroplast creation_date: 2011-02-14T02:20:30Z [Term] id: GO:0072655 name: establishment of protein localization to mitochondrion namespace: biological_process def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrion" EXACT [] is_a: GO:0070585 ! protein localization to mitochondrion is_a: GO:0072594 ! establishment of protein localization to organelle intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005739 ! has target end location mitochondrion creation_date: 2011-02-14T02:28:54Z [Term] id: GO:0072656 name: maintenance of protein location in mitochondrion namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000050 GO:0070585 ! part of protein localization to mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2011-02-14T02:30:43Z [Term] id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] subset: goslim_prokaryote synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [] is_a: GO:0008104 ! intracellular protein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane created_by: mah creation_date: 2011-02-14T02:35:18Z [Term] id: GO:0072659 name: protein localization to plasma membrane namespace: biological_process alt_id: GO:0072661 alt_id: GO:0090002 def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] subset: goslim_generic subset: goslim_pombe synonym: "protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "protein localization in plasma membrane" RELATED [] synonym: "protein targeting to plasma membrane" RELATED [] synonym: "protein-plasma membrane targeting" RELATED [GOC:mah] is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane created_by: tb creation_date: 2009-07-10T10:29:23Z [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002339 GO:0005773 ! has target end location vacuole created_by: mah creation_date: 2011-02-14T02:55:35Z [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole created_by: mah creation_date: 2011-02-14T02:56:29Z [Term] id: GO:0072667 name: maintenance of protein location in vacuole namespace: biological_process def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah] is_a: GO:0072595 ! maintenance of protein localization in organelle intersection_of: GO:0045185 ! maintenance of protein location intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole relationship: BFO:0000050 GO:0072665 ! part of protein localization to vacuole relationship: BFO:0000066 GO:0005773 ! occurs in vacuole creation_date: 2011-02-14T02:56:57Z [Term] id: GO:0072674 name: multinuclear osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016] synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah] synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah] is_a: GO:0030316 ! osteoclast differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000779 ! results in acquisition of features of multinuclear osteoclast relationship: RO:0002315 CL:0000779 ! results in acquisition of features of multinuclear osteoclast creation_date: 2011-02-22T02:10:38Z [Term] id: GO:0072676 name: lymphocyte migration namespace: biological_process def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah] is_a: GO:0071674 ! mononuclear cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000542 ! results in movement of lymphocyte relationship: RO:0002565 CL:0000542 ! results in movement of lymphocyte creation_date: 2011-02-22T03:38:12Z [Term] id: GO:0072678 name: T cell migration namespace: biological_process def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah] synonym: "T lymphocyte migration" EXACT [CL:0000084] synonym: "T-cell migration" EXACT [CL:0000084] synonym: "T-lymphocyte migration" EXACT [CL:0000084] is_a: GO:0072676 ! lymphocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000084 ! results in movement of T cell relationship: RO:0002565 CL:0000084 ! results in movement of T cell creation_date: 2011-02-22T03:40:40Z [Term] id: GO:0072697 name: protein localization to cell cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] synonym: "protein localisation to cell cortex" EXACT [GOC:mah] is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005938 ! has target end location cell cortex relationship: RO:0002339 GO:0005938 ! has target end location cell cortex created_by: mah creation_date: 2012-04-11T01:16:33Z [Term] id: GO:0072698 name: protein localization to microtubule cytoskeleton namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0044380 ! protein localization to cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton relationship: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton creation_date: 2012-04-11T01:19:35Z [Term] id: GO:0075009 name: germ tube formation namespace: biological_process def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] synonym: "germ tube formation on or near host" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: BFO:0000050 GO:0009847 ! part of spore germination [Term] id: GO:0075010 name: regulation of germ tube formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0075009 ! regulates germ tube formation relationship: RO:0002211 GO:0075009 ! regulates germ tube formation [Term] id: GO:0075015 name: formation of infection structure namespace: biological_process def: "The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. synonym: "formation by symbiont of infection structure on or near host" RELATED [] synonym: "formation of host infection structure" EXACT [] synonym: "formation of host penetration structure" RELATED [] synonym: "formation of infection structure on or near host" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: BFO:0000050 GO:0044409 ! part of entry into host [Term] id: GO:0075053 name: penetration peg formation namespace: biological_process alt_id: GO:0075057 def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "formation of symbiont penetration peg for entry into host" RELATED [] synonym: "initiation of symbiont penetration peg" NARROW [] synonym: "symbiont penetration peg formation for entry into host" RELATED [] synonym: "symbiont penetration peg initiation" NARROW [] is_a: GO:0075015 ! formation of infection structure [Term] id: GO:0075054 name: modulation of penetration peg formation namespace: biological_process alt_id: GO:0075058 def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. synonym: "modulation of symbiont penetration peg formation for entry into host" NARROW [] synonym: "modulation of symbiont penetration peg initiation" NARROW [] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0052372 ! modulation by symbiont of entry into host intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0075053 ! regulates penetration peg formation relationship: RO:0002211 GO:0075053 ! regulates penetration peg formation [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044238 ! regulates primary metabolic process relationship: RO:0002211 GO:0044238 ! regulates primary metabolic process created_by: dhl creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080134 name: regulation of response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006950 ! regulates response to stress relationship: RO:0002211 GO:0006950 ! regulates response to stress created_by: dhl creation_date: 2009-05-06T04:51:28Z [Term] id: GO:0080135 name: regulation of cellular response to stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033554 ! regulates cellular response to stress relationship: RO:0002211 GO:0033554 ! regulates cellular response to stress created_by: dhl creation_date: 2009-05-06T05:02:52Z [Term] id: GO:0080154 name: regulation of fertilization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009566 ! regulates fertilization relationship: RO:0002211 GO:0009566 ! regulates fertilization creation_date: 2010-09-01T03:44:27Z [Term] id: GO:0080171 name: lytic vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380] synonym: "lytic vacuolar assembly" NARROW [] synonym: "lytic vacuole biogenesis" RELATED [] synonym: "lytic vacuole organisation" EXACT [] synonym: "lytic vacuole organization and biogenesis" RELATED [] is_a: GO:0007033 ! vacuole organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000323 ! results in organization of lytic vacuole relationship: RO:0002592 GO:0000323 ! results in organization of lytic vacuole creation_date: 2011-04-25T04:40:46Z [Term] id: GO:0085029 name: extracellular matrix assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030198 ! extracellular matrix organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix relationship: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix creation_date: 2010-07-14T12:52:49Z [Term] id: GO:0085030 name: mutualism namespace: biological_process def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism." [GOC:pdt] synonym: "mutualism" RELATED [] is_a: GO:0044403 ! biological process involved in symbiotic interaction created_by: jl creation_date: 2010-07-27T01:25:21Z [Term] id: GO:0086001 name: cardiac muscle cell action potential namespace: biological_process def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell creation_date: 2011-11-10T07:45:11Z [Term] id: GO:0086015 name: SA node cell action potential namespace: biological_process def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell action potential" EXACT [] synonym: "SAN cardiac muscle cell action potential" EXACT [] synonym: "sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node relationship: BFO:0000050 GO:0086018 ! part of SA node cell to atrial cardiac muscle cell signaling relationship: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0086016 name: AV node cell action potential namespace: biological_process def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node relationship: BFO:0000050 GO:0086027 ! part of AV node cell to bundle of His cell signaling relationship: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086017 name: Purkinje myocyte action potential namespace: biological_process def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086001 ! cardiac muscle cell action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte relationship: BFO:0000050 GO:0086029 ! part of Purkinje myocyte to ventricular cardiac muscle cell signaling relationship: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0086018 name: SA node cell to atrial cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW [] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication creation_date: 2011-11-10T09:15:01Z [Term] id: GO:0086019 name: cell-cell signaling involved in cardiac conduction namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling is_a: GO:0086065 ! cell communication involved in cardiac conduction intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000050 GO:0061337 ! part of cardiac conduction creation_date: 2011-11-16T03:43:52Z [Term] id: GO:0086027 name: AV node cell to bundle of His cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node to bundle of His cell signaling" EXACT [] synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086067 ! AV node cell to bundle of His cell communication creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086029 name: Purkinje myocyte to ventricular cardiac muscle cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah] is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0002068 ! has start location Purkinje myocyte intersection_of: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell relationship: RO:0002231 CL:0002068 ! has start location Purkinje myocyte relationship: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell creation_date: 2011-11-11T02:02:14Z [Term] id: GO:0086065 name: cell communication involved in cardiac conduction namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007154 ! cell communication intersection_of: GO:0007154 ! cell communication intersection_of: BFO:0000050 GO:0061337 ! part of cardiac conduction relationship: BFO:0000050 GO:0061337 ! part of cardiac conduction creation_date: 2011-11-22T08:57:02Z [Term] id: GO:0086067 name: AV node cell to bundle of His cell communication namespace: biological_process def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "atrioventricular node cell to bundle of His cell communication" EXACT [] is_a: GO:0086065 ! cell communication involved in cardiac conduction creation_date: 2011-11-22T09:11:44Z [Term] id: GO:0086068 name: Purkinje myocyte to ventricular cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0086065 ! cell communication involved in cardiac conduction creation_date: 2011-11-22T09:14:49Z [Term] id: GO:0086070 name: SA node cell to atrial cardiac muscle cell communication namespace: biological_process def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT [] synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW [] is_a: GO:0086065 ! cell communication involved in cardiac conduction creation_date: 2011-11-22T09:32:45Z [Term] id: GO:0086093 name: G protein-coupled acetylcholine receptor signaling pathway involved in heart process namespace: biological_process def: "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in heart process" EXACT [] synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11] synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11] is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: BFO:0000050 GO:0003015 ! part of heart process [Term] id: GO:0086103 name: G protein-coupled receptor signaling pathway involved in heart process namespace: biological_process def: "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] synonym: "G-protein coupled receptor signaling pathway involved in heart process" EXACT [GOC:bf] synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf] synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf] synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: BFO:0000050 GO:0003015 ! part of heart process relationship: BFO:0000050 GO:0003015 ! part of heart process creation_date: 2012-03-19T01:28:23Z [Term] id: GO:0089704 name: L-glutamate transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0004009 CHEBI:29985 ! has primary input [Term] id: GO:0089718 name: amino acid import across plasma membrane namespace: biological_process def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] synonym: "amino acid import into cell" EXACT [] synonym: "amino acid transmembrane import" BROAD [] synonym: "L-amino acid import" BROAD [] synonym: "L-amino acid uptake" NARROW [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0098739 ! import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion creation_date: 2012-11-14T14:21:41Z [Term] id: GO:0090025 name: regulation of monocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002548 ! regulates monocyte chemotaxis relationship: RO:0002211 GO:0002548 ! regulates monocyte chemotaxis creation_date: 2009-08-03T10:17:03Z [Term] id: GO:0090026 name: positive regulation of monocyte chemotaxis namespace: biological_process def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:0090025 ! regulation of monocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002548 ! positively regulates monocyte chemotaxis relationship: RO:0002213 GO:0002548 ! positively regulates monocyte chemotaxis creation_date: 2009-08-03T10:18:54Z [Term] id: GO:0090027 name: negative regulation of monocyte chemotaxis namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:0090025 ! regulation of monocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002548 ! negatively regulates monocyte chemotaxis relationship: RO:0002212 GO:0002548 ! negatively regulates monocyte chemotaxis creation_date: 2009-08-03T10:19:40Z [Term] id: GO:0090063 name: positive regulation of microtubule nucleation namespace: biological_process def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031116 ! positive regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation relationship: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation creation_date: 2009-08-12T11:33:09Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022402 ! positively regulates cell cycle process relationship: RO:0002213 GO:0022402 ! positively regulates cell cycle process creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090069 name: regulation of ribosome biogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042254 ! regulates ribosome biogenesis relationship: RO:0002211 GO:0042254 ! regulates ribosome biogenesis creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090070 name: positive regulation of ribosome biogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis relationship: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090071 name: negative regulation of ribosome biogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0090069 ! regulation of ribosome biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis relationship: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis creation_date: 2009-09-11T10:32:17Z [Term] id: GO:0090087 name: regulation of peptide transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0015833 ! regulates peptide transport relationship: RO:0002211 GO:0015833 ! regulates peptide transport created_by: tb creation_date: 2009-10-23T11:21:38Z [Term] id: GO:0090091 name: positive regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly relationship: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly creation_date: 2009-11-04T10:03:25Z [Term] id: GO:0090130 name: tissue migration namespace: biological_process def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032501 ! multicellular organismal process creation_date: 2009-12-07T03:13:55Z [Term] id: GO:0090132 name: epithelium migration namespace: biological_process def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090130 ! tissue migration creation_date: 2009-12-07T03:19:34Z [Term] id: GO:0090138 name: regulation of actin cytoskeleton organization by cell-cell adhesion namespace: biological_process def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization creation_date: 2009-12-08T02:05:00Z [Term] id: GO:0090139 name: mitochondrial chromosome packaging namespace: biological_process def: "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "mitochondrial DNA packaging" EXACT [] is_a: GO:0051276 ! chromosome organization intersection_of: GO:0051276 ! chromosome organization intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2009-12-08T02:12:19Z [Term] id: GO:0090140 name: regulation of mitochondrial fission namespace: biological_process def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000266 ! regulates mitochondrial fission relationship: RO:0002211 GO:0000266 ! regulates mitochondrial fission creation_date: 2009-12-08T02:20:48Z [Term] id: GO:0090141 name: positive regulation of mitochondrial fission namespace: biological_process def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000266 ! positively regulates mitochondrial fission relationship: RO:0002213 GO:0000266 ! positively regulates mitochondrial fission creation_date: 2009-12-08T02:20:48Z [Term] id: GO:0090150 name: establishment of protein localization to membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in membrane" EXACT [] is_a: GO:0045184 ! establishment of protein localization is_a: GO:0072657 ! protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0016020 ! has target end location membrane created_by: tb creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090151 name: establishment of protein localization to mitochondrial membrane namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrial membrane" EXACT [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0072655 ! establishment of protein localization to mitochondrion is_a: GO:0090150 ! establishment of protein localization to membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0031966 ! has target end location mitochondrial membrane relationship: RO:0002339 GO:0031966 ! has target end location mitochondrial membrane creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090152 name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission namespace: biological_process def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah] synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT [] is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane intersection_of: GO:0090151 ! establishment of protein localization to mitochondrial membrane intersection_of: BFO:0000050 GO:0000266 ! part of mitochondrial fission relationship: BFO:0000050 GO:0000266 ! part of mitochondrial fission creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090160 name: Golgi to lysosome transport namespace: biological_process def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006896 ! Golgi to vacuole transport is_a: GO:0007041 ! lysosomal transport is_a: GO:0016482 ! cytosolic transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome relationship: RO:0002339 GO:0005764 ! has target end location lysosome creation_date: 2009-12-08T08:35:13Z [Term] id: GO:0090162 name: establishment of epithelial cell polarity namespace: biological_process def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell creation_date: 2009-12-08T08:58:27Z [Term] id: GO:0090166 name: Golgi disassembly namespace: biological_process def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi apparatus disassembly" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus relationship: BFO:0000050 GO:0048313 ! part of Golgi inheritance relationship: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090168 name: Golgi reassembly namespace: biological_process def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "Golgi apparatus reassembly" EXACT [] is_a: GO:0007030 ! Golgi organization is_a: GO:0022607 ! cellular component assembly relationship: BFO:0000050 GO:0048313 ! part of Golgi inheritance creation_date: 2009-12-08T09:15:11Z [Term] id: GO:0090170 name: regulation of Golgi inheritance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048313 ! regulates Golgi inheritance relationship: RO:0002211 GO:0048313 ! regulates Golgi inheritance creation_date: 2009-12-11T10:21:59Z [Term] id: GO:0090171 name: chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000138 ! results in maturation of chondrocyte relationship: BFO:0000050 GO:0002063 ! part of chondrocyte development relationship: RO:0002299 CL:0000138 ! results in maturation of chondrocyte creation_date: 2009-12-11T10:36:02Z [Term] id: GO:0090174 name: organelle membrane fusion namespace: biological_process def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048284 ! organelle fusion is_a: GO:0061025 ! membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: RO:0012008 GO:0031090 ! results in fusion of organelle membrane relationship: RO:0012008 GO:0031090 ! results in fusion of organelle membrane creation_date: 2009-12-11T11:44:58Z [Term] id: GO:0090257 name: regulation of muscle system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003012 ! regulates muscle system process relationship: RO:0002211 GO:0003012 ! regulates muscle system process creation_date: 2010-02-03T11:48:13Z [Term] id: GO:0090258 name: negative regulation of mitochondrial fission namespace: biological_process def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb] synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0090140 ! regulation of mitochondrial fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000266 ! negatively regulates mitochondrial fission relationship: RO:0002212 GO:0000266 ! negatively regulates mitochondrial fission creation_date: 2010-02-03T04:05:32Z [Term] id: GO:0090276 name: regulation of peptide hormone secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030072 ! regulates peptide hormone secretion relationship: RO:0002211 GO:0030072 ! regulates peptide hormone secretion creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090277 name: positive regulation of peptide hormone secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion relationship: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090278 name: negative regulation of peptide hormone secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion relationship: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090289 name: regulation of osteoclast proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002158 ! regulates osteoclast proliferation relationship: RO:0002211 GO:0002158 ! regulates osteoclast proliferation creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090290 name: positive regulation of osteoclast proliferation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070665 ! positive regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002158 ! positively regulates osteoclast proliferation relationship: RO:0002213 GO:0002158 ! positively regulates osteoclast proliferation creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090291 name: negative regulation of osteoclast proliferation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] is_a: GO:0070664 ! negative regulation of leukocyte proliferation is_a: GO:0090289 ! regulation of osteoclast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002158 ! negatively regulates osteoclast proliferation relationship: RO:0002212 GO:0002158 ! negatively regulates osteoclast proliferation creation_date: 2010-02-18T03:11:03Z [Term] id: GO:0090299 name: regulation of neural crest formation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014029 ! regulates neural crest formation relationship: RO:0002211 GO:0014029 ! regulates neural crest formation creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090300 name: positive regulation of neural crest formation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014029 ! positively regulates neural crest formation relationship: RO:0002213 GO:0014029 ! positively regulates neural crest formation creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090301 name: negative regulation of neural crest formation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition is_a: GO:0090299 ! regulation of neural crest formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014029 ! negatively regulates neural crest formation relationship: RO:0002212 GO:0014029 ! negatively regulates neural crest formation creation_date: 2010-03-12T04:08:26Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33696 ! has primary input or output nucleic acid relationship: RO:0004007 CHEBI:33696 ! has primary input or output nucleic acid created_by: tb creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090316 name: positive regulation of intracellular protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051222 ! positive regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport relationship: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090317 name: negative regulation of intracellular protein transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0051224 ! negative regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport relationship: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport creation_date: 2010-04-16T03:45:07Z [Term] id: GO:0090425 name: acinar cell differentiation namespace: biological_process def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb] is_a: GO:0002067 ! glandular epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell relationship: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell creation_date: 2012-05-04T09:24:48Z [Term] id: GO:0090435 name: protein localization to nuclear envelope namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb] synonym: "protein localization in nuclear envelope" EXACT [] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005635 ! has target end location nuclear envelope relationship: RO:0002339 GO:0005635 ! has target end location nuclear envelope created_by: tb creation_date: 2012-07-30T01:50:41Z [Term] id: GO:0090454 name: glutamate transmembrane import into vacuole namespace: biological_process def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb] synonym: "vacuolar glutamate import" RELATED [GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:14321 ! has primary input relationship: RO:0004009 CHEBI:14321 ! has primary input creation_date: 2012-09-24T14:12:46Z [Term] id: GO:0090493 name: catecholamine uptake namespace: biological_process def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb] is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure creation_date: 2012-10-17T11:06:17Z [Term] id: GO:0090497 name: mesenchymal cell migration namespace: biological_process def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb] is_a: GO:0001667 ! ameboidal-type cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0008019 ! results in movement of mesenchymal cell relationship: RO:0002565 CL:0008019 ! results in movement of mesenchymal cell creation_date: 2012-10-17T12:08:17Z [Term] id: GO:0090515 name: L-glutamate transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0090454 ! glutamate transmembrane import into vacuole intersection_of: GO:0015800 ! acidic amino acid transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2012-12-14T11:25:52Z [Term] id: GO:0090596 name: sensory organ morphogenesis namespace: biological_process def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ relationship: BFO:0000050 GO:0007423 ! part of sensory organ development relationship: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ creation_date: 2014-08-22T13:23:20Z [Term] id: GO:0090685 name: RNA localization to nucleus namespace: biological_process def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] synonym: "RNA localisation to nucleus" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus relationship: RO:0002339 GO:0005634 ! has target end location nucleus created_by: tb creation_date: 2016-07-19T17:00:49Z [Term] id: GO:0090741 name: pigment granule membrane namespace: cellular_component def: "Any membrane that is part of a pigment granule." [PMID:11294610] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0048770 ! bounding layer of pigment granule relationship: RO:0002007 GO:0048770 ! bounding layer of pigment granule creation_date: 2017-05-16T22:33:39Z [Term] id: GO:0095500 name: acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "acetylcholine receptor signalling pathway" EXACT [] is_a: GO:0098926 ! postsynaptic signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0015464 ! starts with acetylcholine receptor activity relationship: BFO:0000050 GO:1905145 ! part of cellular response to acetylcholine relationship: RO:0002224 GO:0015464 ! starts with acetylcholine receptor activity [Term] id: GO:0097014 name: ciliary plasm namespace: cellular_component def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". synonym: "cilial cytoplasm" RELATED [] synonym: "ciliary cytoplasm" RELATED [] synonym: "cilium cytoplasm" RELATED [] synonym: "cilium plasm" EXACT [] synonym: "microtubule-based flagellar cytoplasm" RELATED [] synonym: "microtubule-based flagellar matrix" NARROW [] synonym: "microtubule-based flagellum cytoplasm" RELATED [] synonym: "microtubule-based flagellum matrix" NARROW [] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0005929 ! part of cilium relationship: BFO:0000050 GO:0005929 ! part of cilium creation_date: 2011-03-23T01:52:31Z [Term] id: GO:0097026 name: dendritic cell dendrite assembly namespace: biological_process def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351] comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. synonym: "dendritic extension" BROAD [] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0097511 ! results in assembly of dendritic cell dendrite relationship: RO:0002588 GO:0097511 ! results in assembly of dendritic cell dendrite creation_date: 2011-03-31T04:52:53Z [Term] id: GO:0097028 name: dendritic cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr] comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. is_a: GO:1903131 ! mononuclear cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000451 ! results in acquisition of features of dendritic cell relationship: RO:0002315 CL:0000451 ! results in acquisition of features of dendritic cell creation_date: 2011-04-01T10:08:42Z [Term] id: GO:0097048 name: dendritic cell apoptotic process namespace: biological_process def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845] synonym: "dendritic cell apoptosis" NARROW [] is_a: GO:0071887 ! leukocyte apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell creation_date: 2011-05-04T02:18:59Z [Term] id: GO:0097049 name: motor neuron apoptotic process namespace: biological_process def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086] synonym: "motoneuron apoptosis" EXACT [] synonym: "motor neuron apoptosis" NARROW [] is_a: GO:0051402 ! neuron apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000100 ! occurs in motor neuron relationship: BFO:0000066 CL:0000100 ! occurs in motor neuron creation_date: 2011-05-04T02:21:43Z [Term] id: GO:0097054 name: L-glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf] synonym: "L-glutamate anabolism" EXACT [] synonym: "L-glutamate biosynthesis" EXACT [] synonym: "L-glutamate formation" EXACT [] synonym: "L-glutamate synthesis" EXACT [] is_a: GO:0006537 ! glutamate biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:29985 ! has primary output relationship: RO:0004008 CHEBI:29985 ! has primary output creation_date: 2011-05-24T04:30:38Z [Term] id: GO:0097060 name: synaptic membrane namespace: cellular_component def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] subset: goslim_synapse is_a: GO:0098590 ! plasma membrane region intersection_of: GO:0098590 ! plasma membrane region intersection_of: BFO:0000050 GO:0045202 ! part of synapse relationship: BFO:0000050 GO:0045202 ! part of synapse creation_date: 2011-06-07T11:22:09Z [Term] id: GO:0097084 name: vascular associated smooth muscle cell development namespace: biological_process def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] synonym: "vascular smooth muscle cell development" EXACT [] is_a: GO:0055001 ! muscle cell development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell relationship: BFO:0000050 GO:0035886 ! part of vascular associated smooth muscle cell differentiation relationship: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell creation_date: 2011-06-20T04:03:08Z [Term] id: GO:0097094 name: craniofacial suture morphogenesis namespace: biological_process def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0009198 ! results in morphogenesis of craniofacial suture relationship: BFO:0000050 GO:0060349 ! part of bone morphogenesis relationship: BFO:0000050 GO:1904888 ! part of cranial skeletal system development relationship: RO:0002298 UBERON:0009198 ! results in morphogenesis of craniofacial suture creation_date: 2011-07-05T02:51:54Z [Term] id: GO:0097096 name: facial suture morphogenesis namespace: biological_process def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] is_a: GO:0097094 ! craniofacial suture morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0009199 ! results in morphogenesis of facial suture relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002298 UBERON:0009199 ! results in morphogenesis of facial suture creation_date: 2011-07-05T03:06:27Z [Term] id: GO:0097104 name: postsynaptic membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692] subset: goslim_synapse synonym: "post-synaptic membrane assembly" EXACT [] is_a: GO:0001941 ! postsynaptic membrane organization is_a: GO:0071709 ! membrane assembly intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0045211 ! results in assembly of postsynaptic membrane relationship: BFO:0000050 GO:0099068 ! part of postsynapse assembly relationship: RO:0002588 GO:0045211 ! results in assembly of postsynaptic membrane creation_date: 2011-07-27T01:26:49Z [Term] id: GO:0097120 name: receptor localization to synapse namespace: biological_process def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273] synonym: "receptor localisation to synapse" EXACT [] is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0051179 ! localization intersection_of: RO:0002339 GO:0045202 ! has target end location synapse intersection_of: RO:0004009 GO:0098802 ! has primary input plasma membrane signaling receptor complex relationship: RO:0002339 GO:0045202 ! has target end location synapse relationship: RO:0004009 GO:0098802 ! has primary input plasma membrane signaling receptor complex creation_date: 2011-07-31T09:20:30Z [Term] id: GO:0097152 name: mesenchymal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833] synonym: "mesenchymal cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell relationship: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell creation_date: 2011-09-06T02:31:59Z [Term] id: GO:0097154 name: GABAergic neuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000617 ! results in acquisition of features of GABAergic neuron relationship: RO:0002315 CL:0000617 ! results in acquisition of features of GABAergic neuron creation_date: 2011-09-14T09:39:11Z [Term] id: GO:0097164 name: ammonium ion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018] synonym: "ammonium ion metabolism" EXACT [] synonym: "ammonium metabolic process" RELATED [] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:28938 ! has primary input or output ammonium relationship: RO:0004007 CHEBI:28938 ! has primary input or output ammonium created_by: pr creation_date: 2011-09-28T04:21:30Z [Term] id: GO:0097176 name: epoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179] synonym: "epoxide metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: pr creation_date: 2011-10-10T11:29:49Z [Term] id: GO:0097177 name: mitochondrial ribosome binding namespace: molecular_function def: "Binding to a mitochondrial ribosome." [GOC:ans, PMID:20739282] is_a: GO:0043022 ! ribosome binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0005761 ! has primary input mitochondrial ribosome relationship: RO:0004009 GO:0005761 ! has primary input mitochondrial ribosome creation_date: 2011-10-11T03:03:03Z [Term] id: GO:0097190 name: apoptotic signaling pathway namespace: biological_process def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. synonym: "apoptotic signalling pathway" EXACT [GOC:mah] synonym: "induction of apoptosis by extracellular signals" EXACT [] xref: Reactome:R-HSA-193681 "Ceramide signalling" xref: Reactome:R-HSA-204998 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:R-HSA-75157 "FasL/ CD95L signaling" is_a: GO:0007165 ! signal transduction relationship: BFO:0000050 GO:0006915 ! part of apoptotic process creation_date: 2011-11-23T09:30:23Z [Term] id: GO:0097194 name: execution phase of apoptosis namespace: biological_process def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] synonym: "apoptosis" NARROW [] synonym: "execution phase of apoptotic process" EXACT [] xref: Reactome:R-HSA-75153 "Apoptotic execution phase" is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0006915 ! part of apoptotic process relationship: BFO:0000051 GO:0032060 ! has part bleb assembly creation_date: 2011-11-23T09:45:24Z [Term] id: GO:0097212 name: lysosomal membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854] synonym: "lysosomal membrane organisation" EXACT [GOC:mah] synonym: "lysosome membrane organization" EXACT [] is_a: GO:0061024 ! membrane organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0005765 ! results in organization of lysosomal membrane relationship: BFO:0000050 GO:0007040 ! part of lysosome organization relationship: RO:0002592 GO:0005765 ! results in organization of lysosomal membrane creation_date: 2012-01-12T10:16:15Z [Term] id: GO:0097252 name: oligodendrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520] synonym: "oligodendrocyte apoptosis" NARROW [] is_a: GO:0034349 ! glial cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000128 ! occurs in oligodendrocyte relationship: BFO:0000066 CL:0000128 ! occurs in oligodendrocyte creation_date: 2012-03-05T10:51:15Z [Term] id: GO:0097355 name: protein localization to heterochromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah] synonym: "protein localisation to heterochromatin" EXACT [GOC:mah] is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000792 ! has target end location heterochromatin relationship: RO:0002339 GO:0000792 ! has target end location heterochromatin creation_date: 2012-07-03T03:19:07Z [Term] id: GO:0097367 name: carbohydrate derivative binding namespace: molecular_function def: "Binding to a carbohydrate derivative." [GOC:pr] subset: goslim_agr subset: goslim_mouse is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative created_by: pr creation_date: 2012-08-02T13:03:39Z [Term] id: GO:0097386 name: glial cell projection namespace: cellular_component def: "A prolongation or process extending from a glial cell." [GOC:mc] synonym: "glial process" RELATED [] synonym: "glial projection" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000125 ! part of glial cell relationship: BFO:0000050 CL:0000125 ! part of glial cell creation_date: 2012-10-22T13:55:54Z [Term] id: GO:0097402 name: neuroblast migration namespace: biological_process def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000031 ! results in movement of neuroblast (sensu Vertebrata) relationship: RO:0002565 CL:0000031 ! results in movement of neuroblast (sensu Vertebrata) creation_date: 2012-10-29T08:24:37Z [Term] id: GO:0097427 name: microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973] synonym: "microtubule fascicle" EXACT [] xref: NIF_Subcellular:sao1872343973 is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton relationship: BFO:0000051 GO:0005874 ! has part microtubule creation_date: 2012-11-07T15:01:27Z [Term] id: GO:0097435 name: supramolecular fiber organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] synonym: "extracellular fibril organisation" NARROW [] synonym: "extracellular fibril organization" NARROW [] synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah] synonym: "fibril organisation" RELATED [] synonym: "fibril organization" RELATED [] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber relationship: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber creation_date: 2012-11-27T15:46:25Z [Term] id: GO:0097447 name: dendritic tree namespace: cellular_component def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168] xref: NIF_Subcellular:sao172297168 is_a: GO:0043005 ! neuron projection relationship: BFO:0000050 GO:0036477 ! part of somatodendritic compartment relationship: BFO:0000051 GO:0030425 ! has part dendrite creation_date: 2012-12-17T12:31:49Z [Term] id: GO:0097449 name: astrocyte projection namespace: cellular_component def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580] synonym: "astrocyte process" EXACT [] synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894] synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993] xref: NIF_Subcellular:sao1630537580 is_a: GO:0097386 ! glial cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000127 ! part of astrocyte relationship: BFO:0000050 CL:0000127 ! part of astrocyte creation_date: 2012-12-17T13:29:55Z [Term] id: GO:0097454 name: Schwann cell microvillus namespace: cellular_component def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042] xref: NIF_Subcellular:sao1890444066 is_a: GO:0005902 ! microvillus is_a: GO:0097386 ! glial cell projection intersection_of: GO:0005902 ! microvillus intersection_of: BFO:0000050 CL:0002573 ! part of Schwann cell relationship: BFO:0000050 CL:0002573 ! part of Schwann cell creation_date: 2012-12-19T13:01:02Z [Term] id: GO:0097473 name: retinal rod cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487] synonym: "rod photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000604 ! occurs in retinal rod cell relationship: BFO:0000066 CL:0000604 ! occurs in retinal rod cell creation_date: 2013-03-21T09:44:45Z [Term] id: GO:0097474 name: retinal cone cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc] synonym: "cone photoreceptor apoptotic process" EXACT [] is_a: GO:0051402 ! neuron apoptotic process is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000573 ! occurs in retinal cone cell relationship: BFO:0000066 CL:0000573 ! occurs in retinal cone cell creation_date: 2013-03-21T09:46:22Z [Term] id: GO:0097475 name: motor neuron migration namespace: biological_process def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000100 ! results in movement of motor neuron relationship: RO:0002565 CL:0000100 ! results in movement of motor neuron creation_date: 2013-04-23T13:00:46Z [Term] id: GO:0097476 name: spinal cord motor neuron migration namespace: biological_process def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475] is_a: GO:0097475 ! motor neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0011001 ! results in movement of spinal cord motor neuron relationship: RO:0002565 CL:0011001 ! results in movement of spinal cord motor neuron creation_date: 2013-04-23T13:03:46Z [Term] id: GO:0097511 name: dendritic cell dendrite namespace: cellular_component def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351] is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: BFO:0000050 CL:0000451 ! part of dendritic cell relationship: BFO:0000050 CL:0000451 ! part of dendritic cell creation_date: 2013-10-16T13:02:25Z [Term] id: GO:0097512 name: cardiac myofibril namespace: cellular_component def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol] is_a: GO:0030016 ! myofibril intersection_of: GO:0030016 ! myofibril intersection_of: BFO:0000050 CL:0000746 ! part of cardiac muscle cell relationship: BFO:0000050 CL:0000746 ! part of cardiac muscle cell creation_date: 2013-10-16T13:04:58Z [Term] id: GO:0097529 name: myeloid leukocyte migration namespace: biological_process def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000766 ! results in movement of myeloid leukocyte relationship: RO:0002565 CL:0000766 ! results in movement of myeloid leukocyte creation_date: 2013-11-11T13:59:43Z [Term] id: GO:0097530 name: granulocyte migration namespace: biological_process def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336] is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000094 ! results in movement of granulocyte relationship: RO:0002565 CL:0000094 ! results in movement of granulocyte creation_date: 2013-11-11T14:00:44Z [Term] id: GO:0097534 name: lymphoid lineage cell migration namespace: biological_process def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843] synonym: "lymphoid lineage restricted progenitor cell migration" EXACT [] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000838 ! results in movement of lymphoid lineage restricted progenitor cell relationship: RO:0002565 CL:0000838 ! results in movement of lymphoid lineage restricted progenitor cell creation_date: 2013-11-28T10:47:15Z [Term] id: GO:0097576 name: vacuole fusion namespace: biological_process def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole] is_a: GO:0007033 ! vacuole organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0009987 ! cellular process intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole relationship: RO:0012008 GO:0005773 ! results in fusion of vacuole creation_date: 2014-02-28T09:49:31Z [Term] id: GO:0097708 name: intracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure creation_date: 2016-03-29T17:39:45Z [Term] id: GO:0097711 name: ciliary basal body-plasma membrane docking namespace: biological_process def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235] comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. synonym: "anchoring of the basal body to the plasma membrane" RELATED [] synonym: "ciliary basal body docking" EXACT [] xref: Reactome:R-HSA-5620912 "Anchoring of the basal body to the plasma membrane" is_a: GO:0140056 ! organelle localization by membrane tethering relationship: BFO:0000050 GO:0060271 ! part of cilium assembly creation_date: 2016-08-05T16:12:33Z [Term] id: GO:0097712 name: vesicle targeting, trans-Golgi to periciliary membrane compartment namespace: biological_process def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645] is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi relationship: BFO:0000050 GO:0060271 ! part of cilium assembly creation_date: 2016-08-05T16:16:28Z [Term] id: GO:0097734 name: extracellular exosome biogenesis namespace: biological_process def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495] synonym: "exosome assembly or secretion" EXACT [] synonym: "exosome biogenesis" EXACT [] synonym: "exosome production" EXACT [] synonym: "ILV assembly" RELATED [] synonym: "intraluminal vesicle assembly" RELATED [] is_a: GO:0140112 ! extracellular vesicle biogenesis creation_date: 2016-10-03T14:35:25Z [Term] id: GO:0098523 name: neuromuscular junction of myotube namespace: cellular_component def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. is_a: GO:0031594 ! neuromuscular junction intersection_of: GO:0045202 ! synapse intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron intersection_of: RO:0002131 CL:0002372 ! overlaps myotube relationship: RO:0002131 CL:0002372 ! overlaps myotube creation_date: 2013-10-14T12:05:12Z [Term] id: GO:0098528 name: skeletal muscle fiber differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos] is_a: GO:0014902 ! myotube differentiation is_a: GO:0035914 ! skeletal muscle cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber relationship: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber creation_date: 2013-10-15T14:00:34Z [Term] id: GO:0098542 name: defense response to other organism namespace: biological_process alt_id: GO:0009814 def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] subset: goslim_generic subset: goslim_prokaryote synonym: "defence response incompatible interaction" NARROW [] synonym: "defence response to pathogen, incompatible interaction" NARROW [] synonym: "defense response, incompatible interaction" NARROW [] synonym: "resistance response to pathogen" NARROW [] is_a: GO:0006952 ! defense response is_a: GO:0051707 ! response to other organism created_by: dos creation_date: 2013-11-11T12:59:11Z [Term] id: GO:0098544 name: maintenance of protein complex location namespace: biological_process def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0051235 ! maintenance of location intersection_of: GO:0051235 ! maintenance of location intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex creation_date: 2013-11-15T18:20:16Z [Term] id: GO:0098545 name: maintenance of protein complex location in cytoplasm namespace: biological_process def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos] is_a: GO:0051651 ! maintenance of location in cell is_a: GO:0098544 ! maintenance of protein complex location intersection_of: GO:0098544 ! maintenance of protein complex location intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm creation_date: 2013-11-15T20:49:15Z [Term] id: GO:0098588 name: bounding membrane of organelle namespace: cellular_component def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. is_a: GO:0031090 ! organelle membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0043226 ! bounding layer of organelle relationship: RO:0002007 GO:0043226 ! bounding layer of organelle creation_date: 2014-02-26T13:41:31Z [Term] id: GO:0098590 name: plasma membrane region namespace: cellular_component def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. subset: gocheck_do_not_annotate synonym: "region of plasma membrane" EXACT [] is_a: GO:0016020 ! membrane intersection_of: GO:0016020 ! membrane intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane relationship: BFO:0000050 GO:0005886 ! part of plasma membrane created_by: dos creation_date: 2014-03-06T11:55:32Z [Term] id: GO:0098609 name: cell-cell adhesion namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] synonym: "single organismal cell-cell adhesion" RELATED [] is_a: GO:0007155 ! cell adhesion creation_date: 2014-04-16T13:40:03Z [Term] id: GO:0098631 name: cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] subset: goslim_generic subset: goslim_prokaryote synonym: "cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell adhesion" EXACT [] is_a: GO:0050839 ! cell adhesion molecule binding intersection_of: GO:0005488 ! binding intersection_of: BFO:0000050 GO:0007155 ! part of cell adhesion relationship: BFO:0000050 GO:0007155 ! part of cell adhesion [Term] id: GO:0098632 name: cell-cell adhesion mediator activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] synonym: "cell-cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell-cell adhesion" EXACT [] is_a: GO:0098631 ! cell adhesion mediator activity intersection_of: GO:0005515 ! protein binding intersection_of: BFO:0000050 GO:0098609 ! part of cell-cell adhesion relationship: BFO:0000050 GO:0098609 ! part of cell-cell adhesion [Term] id: GO:0098633 name: collagen fibril binding namespace: molecular_function def: "Binding to a collagen fibril." [GOC:dos, PMID:21421911] is_a: GO:0050840 ! extracellular matrix binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0098643 ! has primary input fibrillar collagen relationship: RO:0004009 GO:0098643 ! has primary input fibrillar collagen [Term] id: GO:0098635 name: protein complex involved in cell-cell adhesion namespace: cellular_component def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos] is_a: GO:0098636 ! protein complex involved in cell adhesion intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002216 GO:0098609 ! capable of part of cell-cell adhesion relationship: RO:0002216 GO:0098609 ! capable of part of cell-cell adhesion [Term] id: GO:0098636 name: protein complex involved in cell adhesion namespace: cellular_component def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos] synonym: "cell adhesion complex" RELATED [] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002216 GO:0007155 ! capable of part of cell adhesion relationship: RO:0002216 GO:0007155 ! capable of part of cell adhesion [Term] id: GO:0098641 name: cadherin binding involved in cell-cell adhesion namespace: molecular_function def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos] is_a: GO:0045296 ! cadherin binding is_a: GO:0098632 ! cell-cell adhesion mediator activity intersection_of: GO:0045296 ! cadherin binding intersection_of: BFO:0000050 GO:0098609 ! part of cell-cell adhesion [Term] id: GO:0098642 name: network-forming collagen trimer namespace: cellular_component def: "A collagen trimer that forms networks." [PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0098645 ! part of collagen network relationship: BFO:0000050 GO:0098645 ! part of collagen network [Term] id: GO:0098643 name: fibrillar collagen namespace: cellular_component def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:20386646, PMID:21421911, PMID:29853175] synonym: "banded collagen fibril" EXACT [] is_a: GO:0098644 ! complex of collagen trimers [Term] id: GO:0098644 name: complex of collagen trimers namespace: cellular_component def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos] synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541] synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911] is_a: GO:0099080 ! supramolecular complex relationship: BFO:0000050 GO:0031012 ! part of extracellular matrix relationship: BFO:0000051 GO:0005581 ! has part collagen trimer [Term] id: GO:0098645 name: collagen network namespace: cellular_component def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911] is_a: GO:0098644 ! complex of collagen trimers [Term] id: GO:0098657 name: import into cell namespace: biological_process def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005737 ! has target end location cytoplasm intersection_of: RO:0004009 CHEBI:24431 ! has primary input chemical entity relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005737 ! has target end location cytoplasm relationship: RO:0004009 CHEBI:24431 ! has primary input chemical entity [Term] id: GO:0098664 name: G protein-coupled serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "G-protein coupled serotonin receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002224 GO:0004993 ! starts with G protein-coupled serotonin receptor activity relationship: RO:0002224 GO:0004993 ! starts with G protein-coupled serotonin receptor activity creation_date: 2016-12-21T12:07:58Z [Term] id: GO:0098666 name: G protein-coupled serotonin receptor complex namespace: cellular_component def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie] synonym: "G-protein coupled serotonin receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0004993 ! capable of G protein-coupled serotonin receptor activity relationship: RO:0002215 GO:0004993 ! capable of G protein-coupled serotonin receptor activity relationship: RO:0002216 GO:0098664 ! capable of part of G protein-coupled serotonin receptor signaling pathway creation_date: 2016-12-21T12:28:12Z [Term] id: GO:0098690 name: glycinergic synapse namespace: cellular_component def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0060012 ! capable of synaptic transmission, glycinergic relationship: RO:0002215 GO:0060012 ! capable of synaptic transmission, glycinergic creation_date: 2017-03-07T14:50:33Z [Term] id: GO:0098704 name: carbohydrate import across plasma membrane namespace: biological_process def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "carbohydrate import into cell" EXACT [] is_a: GO:0034219 ! carbohydrate transmembrane transport is_a: GO:0098739 ! import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate creation_date: 2012-05-31T02:45:02Z [Term] id: GO:0098712 name: L-glutamate import across plasma membrane namespace: biological_process def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "L-glutamate import into cell" EXACT [] synonym: "L-glutamate(1-) import across plasma membrane" BROAD [] synonym: "L-glutamate(1-) import into cell" EXACT [] is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2013-06-12T12:32:47Z [Term] id: GO:0098722 name: asymmetric stem cell division namespace: biological_process def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0017145 ! stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell [Term] id: GO:0098723 name: skeletal muscle myofibril namespace: cellular_component def: "A myofibril of a skeletal muscle fiber." [GOC:dos] is_a: GO:0030016 ! myofibril intersection_of: GO:0030016 ! myofibril intersection_of: BFO:0000050 CL:0008002 ! part of skeletal muscle fiber relationship: BFO:0000050 CL:0008002 ! part of skeletal muscle fiber relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: GO:0098728 name: germline stem cell asymmetric division namespace: biological_process def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos] is_a: GO:0042078 ! germ-line stem cell division is_a: GO:0098722 ! asymmetric stem cell division intersection_of: GO:0008356 ! asymmetric cell division intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell [Term] id: GO:0098739 name: import across plasma membrane namespace: biological_process def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "uptake" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0098657 ! import into cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane relationship: RO:0002339 GO:0005829 ! has target end location cytosol relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane [Term] id: GO:0098749 name: cerebellar neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] is_a: GO:0021954 ! central nervous system neuron development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:1001611 ! results in development of cerebellar neuron relationship: BFO:0000050 GO:0021549 ! part of cerebellum development relationship: RO:0002296 CL:1001611 ! results in development of cerebellar neuron [Term] id: GO:0098751 name: bone cell development namespace: biological_process def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. subset: gocheck_do_not_annotate is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0001035 ! results in development of bone cell relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002296 CL:0001035 ! results in development of bone cell [Term] id: GO:0098762 name: meiotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: RO:0002092 GO:0051321 ! happens during meiotic cell cycle relationship: RO:0002092 GO:0051321 ! happens during meiotic cell cycle [Term] id: GO:0098764 name: meiosis I cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase [Term] id: GO:0098773 name: skin epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos] is_a: GO:0008544 ! epidermis development is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001003 ! results in development of skin epidermis relationship: BFO:0000050 GO:0043588 ! part of skin development relationship: RO:0002296 UBERON:0001003 ! results in development of skin epidermis [Term] id: GO:0098793 name: presynapse namespace: cellular_component def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos] subset: goslim_synapse synonym: "presynaptic terminal" EXACT [] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 GO:0045202 ! part of synapse relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0098794 name: postsynapse namespace: cellular_component def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] subset: goslim_synapse is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell relationship: BFO:0000050 GO:0045202 ! part of synapse [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0016020 ! part of membrane relationship: BFO:0000050 GO:0016020 ! part of membrane [Term] id: GO:0098797 name: plasma membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane relationship: BFO:0000050 GO:0005886 ! part of plasma membrane [Term] id: GO:0098798 name: mitochondrial protein-containing complex namespace: cellular_component def: "A protein complex that is part of a mitochondrion." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "mitochondrial protein complex" RELATED [] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion relationship: BFO:0000050 GO:0005739 ! part of mitochondrion [Term] id: GO:0098799 name: outer mitochondrial membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos] is_a: GO:0098796 ! membrane protein complex is_a: GO:0098798 ! mitochondrial protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005741 ! part of mitochondrial outer membrane relationship: BFO:0000050 GO:0005741 ! part of mitochondrial outer membrane [Term] id: GO:0098802 name: plasma membrane signaling receptor complex namespace: cellular_component def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate is_a: GO:0043235 ! receptor complex is_a: GO:0098797 ! plasma membrane protein complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity [Term] id: GO:0098813 name: nuclear chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] is_a: GO:0007059 ! chromosome segregation [Term] id: GO:0098840 name: protein transport along microtubule namespace: biological_process def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] synonym: "microtubule-based protein transport" BROAD [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0098852 name: lytic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos] is_a: GO:0005774 ! vacuolar membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0000323 ! bounding layer of lytic vacuole relationship: RO:0002007 GO:0000323 ! bounding layer of lytic vacuole [Term] id: GO:0098858 name: actin-based cell projection namespace: cellular_component def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: BFO:0000051 GO:0005884 ! has part actin filament [Term] id: GO:0098862 name: cluster of actin-based cell projections namespace: cellular_component def: "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] is_a: GO:0110165 ! cellular anatomical structure relationship: BFO:0000050 CL:0000000 ! part of cell relationship: BFO:0000051 GO:0098858 ! has part actin-based cell projection [Term] id: GO:0098867 name: intramembranous bone growth namespace: biological_process def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone relationship: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone [Term] id: GO:0098868 name: bone growth namespace: biological_process def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos] is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0001474 ! results in growth of bone element relationship: BFO:0000050 GO:0060348 ! part of bone development relationship: RO:0002343 UBERON:0001474 ! results in growth of bone element [Term] id: GO:0098871 name: postsynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099571 ! postsynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0098876 name: vesicle-mediated transport to the plasma membrane namespace: biological_process def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0051668 ! localization within membrane intersection_of: GO:0006810 ! transport intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle relationship: RO:0002230 GO:0006887 ! ends with exocytosis relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane [Term] id: GO:0098877 name: neurotransmitter receptor transport to plasma membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0098878 name: neurotransmitter receptor complex namespace: cellular_component def: "Any protein complex that is capable of functioning as a neurotransmitter receptor." [GOC:dos] is_a: GO:0098802 ! plasma membrane signaling receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0030594 ! capable of neurotransmitter receptor activity relationship: RO:0002215 GO:0030594 ! capable of neurotransmitter receptor activity [Term] id: GO:0098883 name: synapse pruning namespace: biological_process def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190] subset: goslim_synapse synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716] synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190] synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716] is_a: GO:0050808 ! synapse organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0045202 ! results in disassembly of synapse relationship: RO:0002590 GO:0045202 ! results in disassembly of synapse [Term] id: GO:0098900 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0001508 ! regulates action potential relationship: RO:0002211 GO:0001508 ! regulates action potential [Term] id: GO:0098901 name: regulation of cardiac muscle cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential relationship: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential [Term] id: GO:0098904 name: regulation of AV node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] synonym: "regulation of AV node cardiac muscle cell action potential" EXACT [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086016 ! regulates AV node cell action potential relationship: RO:0002211 GO:0086016 ! regulates AV node cell action potential creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098906 name: regulation of Purkinje myocyte action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential relationship: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential creation_date: 2011-11-10T08:58:56Z [Term] id: GO:0098907 name: regulation of SA node cell action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "regulation of SA node cardiac muscle cell action potential" EXACT [] synonym: "regulation of SAN cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW [] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0098901 ! regulation of cardiac muscle cell action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0086015 ! regulates SA node cell action potential relationship: RO:0002211 GO:0086015 ! regulates SA node cell action potential creation_date: 2011-11-10T08:50:15Z [Term] id: GO:0098908 name: regulation of neuronal action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0051969 ! regulation of transmission of nerve impulse is_a: GO:0098900 ! regulation of action potential intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0019228 ! regulates neuronal action potential relationship: RO:0002211 GO:0019228 ! regulates neuronal action potential [Term] id: GO:0098916 name: anterograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098793 ! has start location presynapse intersection_of: RO:0002232 GO:0098794 ! has end location postsynapse relationship: RO:0002231 GO:0098793 ! has start location presynapse relationship: RO:0002232 GO:0098794 ! has end location postsynapse [Term] id: GO:0098917 name: retrograde trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos] is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse relationship: RO:0002231 GO:0098794 ! has start location postsynapse relationship: RO:0002232 GO:0098793 ! has end location presynapse [Term] id: GO:0098920 name: retrograde trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099541 ! trans-synaptic signaling by lipid intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid [Term] id: GO:0098926 name: postsynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse relationship: BFO:0000050 GO:0099536 ! part of synaptic signaling relationship: RO:0002231 GO:0098794 ! has start location postsynapse [Term] id: GO:0098928 name: presynaptic signal transduction namespace: biological_process def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: RO:0002231 GO:0098793 ! has start location presynapse relationship: RO:0002231 GO:0098793 ! has start location presynapse [Term] id: GO:0098930 name: axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" EXACT [] synonym: "axoplasmic transport" EXACT [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0008088 ! axo-dendritic transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0030424 ! occurs in axon intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0030424 ! occurs in axon [Term] id: GO:0098934 name: retrograde dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos] subset: goslim_synapse is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm relationship: RO:0002338 GO:0098793 ! has target start location presynapse [Term] id: GO:0098935 name: dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194] subset: goslim_synapse synonym: "dendrite cargo transport" EXACT [] is_a: GO:0008088 ! axo-dendritic transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0030425 ! occurs in dendrite intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0030425 ! occurs in dendrite [Term] id: GO:0098937 name: anterograde dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194] subset: goslim_synapse is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm relationship: RO:0002339 GO:0098794 ! has target end location postsynapse [Term] id: GO:0098939 name: dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai] subset: goslim_synapse is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm [Term] id: GO:0098957 name: anterograde axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] subset: goslim_synapse synonym: "anterograde axon transport of mitochondria" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0019896 ! axonal transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0098958 name: retrograde axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos] subset: goslim_synapse synonym: "retrograde axon transport of mitochondria" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0019896 ! axonal transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0098959 name: retrograde dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos] subset: goslim_synapse synonym: "retrograde dendrite transport of mitochondria" EXACT [] is_a: GO:0098939 ! dendritic transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002338 GO:0098794 ! has target start location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion relationship: RO:0002338 GO:0098794 ! has target start location postsynapse [Term] id: GO:0098960 name: postsynaptic neurotransmitter receptor activity namespace: molecular_function def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane during synaptic transmission." [GOC:dos, GOC:signaling] synonym: "neurotransmitter receptor activity involved in chemical synaptic transmission" EXACT [] is_a: GO:0030594 ! neurotransmitter receptor activity intersection_of: GO:0030594 ! neurotransmitter receptor activity intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000050 GO:0099565 ! part of chemical synaptic transmission, postsynaptic relationship: BFO:0000066 GO:0045211 ! occurs in postsynaptic membrane [Term] id: GO:0098961 name: dendritic transport of ribonucleoprotein complex namespace: biological_process def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos] subset: goslim_synapse synonym: "dendritic transport of RNP complex" EXACT [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm relationship: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex [Term] id: GO:0098962 name: regulation of postsynaptic neurotransmitter receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0031644 ! regulation of nervous system process is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099601 ! regulation of neurotransmitter receptor activity intersection_of: GO:0065009 ! regulation of molecular function intersection_of: RO:0002211 GO:0098960 ! regulates postsynaptic neurotransmitter receptor activity relationship: RO:0002211 GO:0098960 ! regulates postsynaptic neurotransmitter receptor activity [Term] id: GO:0098967 name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane namespace: biological_process def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082] subset: goslim_synapse is_a: GO:0006887 ! exocytosis is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels intersection_of: GO:0006887 ! exocytosis intersection_of: BFO:0000050 GO:0098969 ! part of neurotransmitter receptor transport to postsynaptic membrane relationship: BFO:0000050 GO:0098969 ! part of neurotransmitter receptor transport to postsynaptic membrane [Term] id: GO:0098969 name: neurotransmitter receptor transport to postsynaptic membrane namespace: biological_process def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane intersection_of: GO:0015031 ! protein transport intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0098971 name: anterograde dendritic transport of neurotransmitter receptor complex namespace: biological_process def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098937 ! anterograde dendritic transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex relationship: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0098972 name: anterograde dendritic transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos] subset: goslim_synapse is_a: GO:0098937 ! anterograde dendritic transport is_a: GO:0098939 ! dendritic transport of mitochondrion intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion [Term] id: GO:0098974 name: postsynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099188 ! postsynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton relationship: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton [Term] id: GO:0098975 name: postsynapse of neuromuscular junction namespace: cellular_component def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502] is_a: GO:0098794 ! postsynapse intersection_of: GO:0098794 ! postsynapse intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell intersection_of: BFO:0000050 GO:0031594 ! part of neuromuscular junction relationship: BFO:0000050 CL:0000187 ! part of muscle cell relationship: BFO:0000050 GO:0031594 ! part of neuromuscular junction [Term] id: GO:0098978 name: glutamatergic synapse namespace: cellular_component def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0035249 ! capable of synaptic transmission, glutamatergic relationship: RO:0002215 GO:0035249 ! capable of synaptic transmission, glutamatergic [Term] id: GO:0098981 name: cholinergic synapse namespace: cellular_component def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0007271 ! capable of synaptic transmission, cholinergic relationship: RO:0002215 GO:0007271 ! capable of synaptic transmission, cholinergic [Term] id: GO:0098982 name: GABA-ergic synapse namespace: cellular_component def: "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory." [GOC:dos] subset: goslim_synapse is_a: GO:0045202 ! synapse intersection_of: GO:0045202 ! synapse intersection_of: RO:0002215 GO:0051932 ! capable of synaptic transmission, GABAergic relationship: RO:0002215 GO:0051932 ! capable of synaptic transmission, GABAergic [Term] id: GO:0098988 name: G protein-coupled glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [GOC:dos] synonym: "G-protein coupled glutamate receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0008066 ! glutamate receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: RO:0004009 CHEBI:14321 ! has primary input [Term] id: GO:0098992 name: neuronal dense core vesicle namespace: cellular_component def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] subset: goslim_synapse is_a: GO:0031045 ! dense core granule intersection_of: GO:0031045 ! dense core granule intersection_of: BFO:0000050 CL:0000540 ! part of neuron relationship: BFO:0000050 CL:0000540 ! part of neuron relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: GO:0099003 name: vesicle-mediated transport in synapse namespace: biological_process def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0099012 name: neuronal dense core vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos] subset: goslim_synapse is_a: GO:0032127 ! dense core granule membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0098992 ! bounding layer of neuronal dense core vesicle relationship: RO:0002007 GO:0098992 ! bounding layer of neuronal dense core vesicle [Term] id: GO:0099014 name: neuronal dense core vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos] is_a: GO:0061109 ! dense core granule organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle relationship: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle [Term] id: GO:0099054 name: presynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494] subset: goslim_synapse synonym: "presynapse biogenesis" EXACT [GOC:mah] synonym: "presynaptic terminal assembly" EXACT [PMID:24449494] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099172 ! presynapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0098793 ! results in assembly of presynapse relationship: BFO:0000050 GO:0007416 ! part of synapse assembly relationship: RO:0002588 GO:0098793 ! results in assembly of presynapse [Term] id: GO:0099068 name: postsynapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL] synonym: "postsynapse biogenesis" EXACT [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0099173 ! postsynapse organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002588 GO:0098794 ! results in assembly of postsynapse relationship: BFO:0000050 GO:0007416 ! part of synapse assembly relationship: RO:0002588 GO:0098794 ! results in assembly of postsynapse [Term] id: GO:0099072 name: regulation of postsynaptic membrane neurotransmitter receptor levels namespace: biological_process def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0099074 name: mitochondrion to lysosome vesicle-mediated transport namespace: biological_process def: "Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] synonym: "mitochondrion to lysosome transport" EXACT [] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0007041 ! lysosomal transport is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005739 ! has target start location mitochondrion intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome relationship: RO:0002339 GO:0005764 ! has target end location lysosome [Term] id: GO:0099075 name: mitochondrion-derived vesicle mediated transport namespace: biological_process def: "Vesicle-mediated transport of cargo from the mitochondrion by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655, PMID:37131163] is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: RO:0002338 GO:0005739 ! has target start location mitochondrion relationship: RO:0002338 GO:0005739 ! has target start location mitochondrion [Term] id: GO:0099080 name: supramolecular complex namespace: cellular_component def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] subset: gocheck_do_not_annotate is_a: GO:0110165 ! cellular anatomical structure [Term] id: GO:0099081 name: supramolecular polymer namespace: cellular_component def: "A polymeric supramolecular structure." [GOC:dos] is_a: GO:0099080 ! supramolecular complex intersection_of: GO:0099080 ! supramolecular complex intersection_of: RO:0000053 PATO:0015006 ! bearer of polymeric relationship: RO:0000053 PATO:0015006 ! bearer of polymeric [Term] id: GO:0099082 name: retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] subset: goslim_synapse is_a: GO:0098917 ! retrograde trans-synaptic signaling is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099083 name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse intersection_of: RO:0002232 GO:0098793 ! has end location presynapse intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099098 name: microtubule polymerization based movement namespace: biological_process def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194] is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: BFO:0000051 GO:0046785 ! has part microtubule polymerization relationship: BFO:0000051 GO:0046785 ! has part microtubule polymerization [Term] id: GO:0099111 name: microtubule-based transport namespace: biological_process def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule [Term] id: GO:0099112 name: microtubule polymerization based protein transport namespace: biological_process def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000051 GO:0046785 ! has part microtubule polymerization intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000051 GO:0046785 ! has part microtubule polymerization [Term] id: GO:0099118 name: microtubule-based protein transport namespace: biological_process def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] is_a: GO:0007017 ! microtubule-based process is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099140 name: presynaptic actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0099187 ! presynaptic cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton relationship: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton creation_date: 2017-06-09T18:34:19Z [Term] id: GO:0099143 name: presynaptic actin cytoskeleton namespace: cellular_component def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0015629 ! actin cytoskeleton is_a: GO:0099569 ! presynaptic cytoskeleton intersection_of: GO:0015629 ! actin cytoskeleton intersection_of: BFO:0000050 GO:0098793 ! part of presynapse creation_date: 2017-06-09T18:36:19Z [Term] id: GO:0099145 name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos] subset: goslim_synapse is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0051223 ! regulation of protein transport is_a: GO:0065008 ! regulation of biological quality is_a: GO:1902683 ! regulation of receptor localization to synapse is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098967 ! regulates exocytic insertion of neurotransmitter receptor to postsynaptic membrane relationship: RO:0002211 GO:0098967 ! regulates exocytic insertion of neurotransmitter receptor to postsynaptic membrane creation_date: 2017-06-09T18:49:26Z [Term] id: GO:0099156 name: cell-cell signaling via exosome namespace: biological_process def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038] synonym: "exosome mediated" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome relationship: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome creation_date: 2017-07-05T16:40:45Z [Term] id: GO:0099157 name: trans-synaptic signaling via exosome namespace: biological_process def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038] subset: goslim_synapse synonym: "exosome mediated transynaptic signalling" EXACT [] synonym: "trans-synaptic signalling via exosome" EXACT [] is_a: GO:0099156 ! cell-cell signaling via exosome is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome creation_date: 2017-07-05T16:49:44Z [Term] id: GO:0099170 name: postsynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2017-09-11T17:09:17Z [Term] id: GO:0099171 name: presynaptic modulation of chemical synaptic transmission namespace: biological_process def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos] subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2017-09-11T17:09:31Z [Term] id: GO:0099172 name: presynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos] subset: goslim_synapse synonym: "presynapse development" EXACT [] synonym: "presynapse morphogenesis" RELATED [GOC:BHF] synonym: "presynapse organisation" EXACT [] synonym: "presynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0098793 ! results in organization of presynapse relationship: BFO:0000050 GO:0050808 ! part of synapse organization relationship: RO:0002592 GO:0098793 ! results in organization of presynapse [Term] id: GO:0099173 name: postsynapse organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos] subset: goslim_synapse synonym: "postsynapse development" EXACT [] synonym: "postsynapse morphogenesis" RELATED [GOC:BHF] synonym: "postsynapse organisation" EXACT [] synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0098794 ! results in organization of postsynapse relationship: BFO:0000050 GO:0050808 ! part of synapse organization relationship: RO:0002592 GO:0098794 ! results in organization of postsynapse [Term] id: GO:0099174 name: regulation of presynapse organization namespace: biological_process def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of presynapse organisation" EXACT [GOC:mah] synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of presynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099172 ! regulates presynapse organization relationship: RO:0002211 GO:0099172 ! regulates presynapse organization [Term] id: GO:0099175 name: regulation of postsynapse organization namespace: biological_process def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_synapse synonym: "regulation of postsynapse organisation" EXACT [GOC:mah] synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah] synonym: "regulation of postsynapse structure" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099173 ! regulates postsynapse organization relationship: RO:0002211 GO:0099173 ! regulates postsynapse organization [Term] id: GO:0099177 name: regulation of trans-synaptic signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling relationship: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling [Term] id: GO:0099187 name: presynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos] is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0009987 ! cellular process intersection_of: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton relationship: BFO:0000050 GO:0099172 ! part of presynapse organization relationship: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton creation_date: 2017-12-20T15:05:34Z [Term] id: GO:0099188 name: postsynaptic cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] subset: goslim_synapse is_a: GO:0007010 ! cytoskeleton organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton relationship: BFO:0000050 GO:0099173 ! part of postsynapse organization relationship: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton creation_date: 2017-12-20T15:06:57Z [Term] id: GO:0099500 name: vesicle fusion to plasma membrane namespace: biological_process def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] is_a: GO:0006906 ! vesicle fusion is_a: GO:0140029 ! exocytic process intersection_of: GO:0061025 ! membrane fusion intersection_of: BFO:0000050 GO:0006887 ! part of exocytosis intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane intersection_of: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region relationship: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region [Term] id: GO:0099501 name: exocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030658 ! transport vesicle membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0070382 ! bounding layer of exocytic vesicle relationship: RO:0002007 GO:0070382 ! bounding layer of exocytic vesicle [Term] id: GO:0099503 name: secretory vesicle namespace: cellular_component def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] subset: goslim_drosophila is_a: GO:0031410 ! cytoplasmic vesicle intersection_of: GO:0031982 ! vesicle intersection_of: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane relationship: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane [Term] id: GO:0099512 name: supramolecular fiber namespace: cellular_component def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] synonym: "fibril" RELATED [] is_a: GO:0099081 ! supramolecular polymer intersection_of: GO:0099080 ! supramolecular complex intersection_of: RO:0000053 PATO:0002309 ! bearer of fiber shaped intersection_of: RO:0000053 PATO:0015006 ! bearer of polymeric relationship: RO:0000053 PATO:0002309 ! bearer of fiber shaped [Term] id: GO:0099513 name: polymeric cytoskeletal fiber namespace: cellular_component def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] is_a: GO:0099512 ! supramolecular fiber intersection_of: GO:0099512 ! supramolecular fiber intersection_of: BFO:0000050 GO:0005856 ! part of cytoskeleton intersection_of: RO:0000053 PATO:0015006 ! bearer of polymeric relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton [Term] id: GO:0099515 name: actin filament-based transport namespace: biological_process def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament relationship: RO:0002341 GO:0005884 ! results in transport along actin filament creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0099518 name: vesicle cytoskeletal trafficking namespace: biological_process def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl] synonym: "vesicle cytoskeletal transport" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle [Term] id: GO:0099519 name: dense core granule cytoskeletal transport namespace: biological_process def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451] synonym: "dense core vesicle cytoskeletal trafficking" EXACT [] is_a: GO:0099518 ! vesicle cytoskeletal trafficking is_a: GO:1901950 ! dense core granule transport intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0030424 ! occurs in axon intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule relationship: BFO:0000066 GO:0030424 ! occurs in axon [Term] id: GO:0099522 name: cytosolic region namespace: cellular_component def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] subset: gocheck_do_not_annotate synonym: "region of cytosol" EXACT [] is_a: GO:0005829 ! cytosol intersection_of: GO:0005829 ! cytosol intersection_of: BFO:0000050 GO:0005829 ! part of cytosol relationship: BFO:0000050 GO:0005829 ! part of cytosol [Term] id: GO:0099523 name: presynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! cytosolic region intersection_of: GO:0005829 ! cytosol intersection_of: BFO:0000050 GO:0005829 ! part of cytosol intersection_of: BFO:0000050 GO:0098793 ! part of presynapse relationship: BFO:0000050 GO:0098793 ! part of presynapse [Term] id: GO:0099524 name: postsynaptic cytosol namespace: cellular_component def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0099522 ! cytosolic region intersection_of: GO:0005829 ! cytosol intersection_of: BFO:0000050 GO:0005829 ! part of cytosol intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse relationship: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0099528 name: G protein-coupled neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "G-protein coupled neurotransmitter receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0099531 name: presynaptic process involved in chemical synaptic transmission namespace: biological_process def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos] subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000066 GO:0098793 ! occurs in presynapse [Term] id: GO:0099536 name: synaptic signaling namespace: biological_process def: "Cell-cell signaling to, from or within a synapse." [GOC:dos] subset: goslim_drosophila subset: goslim_synapse is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: GO:0099537 name: trans-synaptic signaling namespace: biological_process def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling [Term] id: GO:0099538 name: synaptic signaling via neuropeptide namespace: biological_process def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos] subset: goslim_synapse is_a: GO:0099536 ! synaptic signaling intersection_of: GO:0099536 ! synaptic signaling intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion relationship: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099540 name: trans-synaptic signaling by neuropeptide namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling is_a: GO:0099538 ! synaptic signaling via neuropeptide intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099541 name: trans-synaptic signaling by lipid namespace: biological_process def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos] subset: goslim_synapse is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid relationship: RO:0002608 CHEBI:18059 ! process has causal agent lipid [Term] id: GO:0099546 name: protein catabolic process, modulating synaptic transmission namespace: biological_process def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099547 name: regulation of translation at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099550 name: trans-synaptic signaling, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099551 name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion [Term] id: GO:0099552 name: trans-synaptic signaling by lipid, modulating synaptic transmission namespace: biological_process def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099541 ! trans-synaptic signaling by lipid is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid [Term] id: GO:0099565 name: chemical synaptic transmission, postsynaptic namespace: biological_process def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0050877 ! nervous system process intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse [Term] id: GO:0099568 name: cytoplasmic region namespace: cellular_component def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] subset: gocheck_do_not_annotate is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0099569 name: presynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: BFO:0000050 GO:0098793 ! part of presynapse relationship: BFO:0000050 GO:0098793 ! part of presynapse [Term] id: GO:0099571 name: postsynaptic cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835] subset: goslim_synapse is_a: GO:0005856 ! cytoskeleton intersection_of: GO:0005856 ! cytoskeleton intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse relationship: BFO:0000050 GO:0098794 ! part of postsynapse [Term] id: GO:0099574 name: regulation of protein catabolic process at synapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein [Term] id: GO:0099575 name: regulation of protein catabolic process at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099576 name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission intersection_of: GO:0042176 ! regulation of protein catabolic process intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099577 name: regulation of translation at presynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140244 ! regulation of translation at presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099578 name: regulation of translation at postsynapse, modulating synaptic transmission namespace: biological_process def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission is_a: GO:0140245 ! regulation of translation at postsynapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission [Term] id: GO:0099601 name: regulation of neurotransmitter receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0010469 ! regulation of signaling receptor activity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030594 ! regulates neurotransmitter receptor activity relationship: RO:0002211 GO:0030594 ! regulates neurotransmitter receptor activity [Term] id: GO:0099612 name: protein localization to axon namespace: biological_process def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0030424 ! has target end location axon relationship: RO:0002339 GO:0030424 ! has target end location axon [Term] id: GO:0099632 name: protein transport within plasma membrane namespace: biological_process def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] is_a: GO:0032594 ! protein transport within lipid bilayer intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005886 ! occurs in plasma membrane intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: BFO:0000066 GO:0005886 ! occurs in plasma membrane [Term] id: GO:0099637 name: neurotransmitter receptor transport namespace: biological_process def: "The directed movement of neurotransmitter receptors." [GOC:dos] subset: goslim_synapse is_a: GO:0015031 ! protein transport is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0015031 ! protein transport intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex relationship: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex [Term] id: GO:0099640 name: axo-dendritic protein transport namespace: biological_process def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axonal protein transport" NARROW [] is_a: GO:0008088 ! axo-dendritic transport is_a: GO:0098840 ! protein transport along microtubule intersection_of: GO:0046907 ! intracellular transport intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099641 name: anterograde axonal protein transport namespace: biological_process def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos] subset: goslim_synapse synonym: "anterograde axon cargo transport" BROAD [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport is_a: GO:1905383 ! protein localization to presynapse intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099642 name: retrograde axonal protein transport namespace: biological_process def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" BROAD [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 PR:000000001 ! has primary input protein [Term] id: GO:0099643 name: signal release from synapse namespace: biological_process def: "Any signal release from a synapse." [GOC:dos] subset: goslim_synapse is_a: GO:0023061 ! signal release intersection_of: GO:0023061 ! signal release intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000050 GO:0099536 ! part of synaptic signaling [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos] subset: gocheck_do_not_annotate synonym: "perimembrane region" EXACT [] is_a: GO:0005938 ! cell cortex is_a: GO:0099568 ! cytoplasmic region intersection_of: GO:0005938 ! cell cortex intersection_of: BFO:0000050 GO:0005938 ! part of cell cortex relationship: BFO:0000050 GO:0005938 ! part of cell cortex [Term] id: GO:0100001 name: regulation of skeletal muscle contraction by action potential namespace: biological_process def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol] is_a: GO:0001508 ! action potential is_a: GO:0014819 ! regulation of skeletal muscle contraction intersection_of: GO:0001508 ! action potential intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction creation_date: 2015-04-02T04:13:19Z [Term] id: GO:0101023 name: vascular endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774] is_a: GO:0001935 ! endothelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell relationship: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell [Term] id: GO:0101024 name: mitotic nuclear membrane organization namespace: biological_process def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872] comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT [] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0071763 ! nuclear membrane organization intersection_of: BFO:0000050 GO:0140014 ! part of mitotic nuclear division relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division [Term] id: GO:0101025 name: nuclear membrane biogenesis namespace: biological_process def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] is_a: GO:0044091 ! membrane biogenesis intersection_of: GO:0044085 ! cellular component biogenesis intersection_of: RO:0004008 GO:0031965 ! has primary output nuclear membrane relationship: BFO:0000050 GO:0071763 ! part of nuclear membrane organization relationship: RO:0004008 GO:0031965 ! has primary output nuclear membrane [Term] id: GO:0106027 name: neuron projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923] is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0043005 ! results in organization of neuron projection relationship: RO:0002592 GO:0043005 ! results in organization of neuron projection creation_date: 2017-06-23T18:30:18Z [Term] id: GO:0106110 name: vomitoxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." [https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056] synonym: "deoxynivalenol biosynthetic process" EXACT [] synonym: "DON biosynthetic process" EXACT [] synonym: "vomitoxin anabolism" EXACT [] synonym: "vomitoxin biosynthesis" EXACT [] synonym: "vomitoxin formation" EXACT [] synonym: "vomitoxin synthesis" EXACT [] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0097176 ! epoxide metabolic process is_a: GO:0120255 ! olefinic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: hjd creation_date: 2018-04-16T19:06:06Z [Term] id: GO:0106214 name: regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:1903358 ! regulation of Golgi organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus relationship: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus creation_date: 2019-06-27T15:12:22Z [Term] id: GO:0106215 name: negative regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus relationship: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus creation_date: 2019-06-27T15:17:17Z [Term] id: GO:0106216 name: positive regulation of vesicle fusion with Golgi apparatus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus relationship: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus creation_date: 2019-06-27T15:20:59Z [Term] id: GO:0106259 name: symbiont-mediated cell-to-cell migration in host namespace: biological_process def: "The directional movement of a symbiont from one host cell to another." [GOC:vw, PMID:18456802, PMID:19262673, PMID:19816653, PMID:29567712] synonym: "cell-to-cell migration in host" EXACT [] synonym: "symbiont-mediated dissemination across host cells" EXACT [] is_a: GO:0044001 ! migration in host created_by: hjd creation_date: 2020-05-01T14:09:35Z [Term] id: GO:0110011 name: regulation of basement membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071711 ! regulates basement membrane organization relationship: RO:0002211 GO:0071711 ! regulates basement membrane organization [Term] id: GO:0110020 name: regulation of actomyosin structure organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195] is_a: GO:0032956 ! regulation of actin cytoskeleton organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031032 ! regulates actomyosin structure organization relationship: RO:0002211 GO:0031032 ! regulates actomyosin structure organization creation_date: 2017-06-20T19:28:58Z [Term] id: GO:0110021 name: cardiac muscle myoblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0051450 ! myoblast proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast relationship: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast creation_date: 2017-06-29T14:35:24Z [Term] id: GO:0110022 name: regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation relationship: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation creation_date: 2017-06-29T15:11:47Z [Term] id: GO:0110023 name: negative regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000818 ! negative regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation relationship: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation creation_date: 2017-06-29T15:18:30Z [Term] id: GO:0110024 name: positive regulation of cardiac muscle myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation is_a: GO:2000288 ! positive regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation relationship: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation creation_date: 2017-06-29T15:24:16Z [Term] id: GO:0110053 name: regulation of actin filament organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] is_a: GO:0032956 ! regulation of actin cytoskeleton organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007015 ! regulates actin filament organization relationship: RO:0002211 GO:0007015 ! regulates actin filament organization creation_date: 2017-09-20T19:52:57Z [Term] id: GO:0110057 name: regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045601 ! regulation of endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation relationship: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation creation_date: 2017-10-23T14:32:09Z [Term] id: GO:0110058 name: positive regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045603 ! positive regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation relationship: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation creation_date: 2017-10-23T14:38:19Z [Term] id: GO:0110059 name: negative regulation of blood vessel endothelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation relationship: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation creation_date: 2017-10-23T14:47:29Z [Term] id: GO:0110077 name: vesicle-mediated intercellular transport namespace: biological_process def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916] synonym: "endosomal trafficking" RELATED [] is_a: GO:0010496 ! intercellular transport is_a: GO:0016192 ! vesicle-mediated transport intersection_of: GO:0010496 ! intercellular transport intersection_of: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle relationship: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle creation_date: 2018-01-29T14:46:52Z [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis relationship: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis creation_date: 2018-07-05T14:10:14Z [Term] id: GO:0110111 name: negative regulation of animal organ morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis relationship: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis creation_date: 2018-07-05T14:25:21Z [Term] id: GO:0110116 name: regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046532 ! regulation of photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation relationship: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation creation_date: 2018-07-16T18:08:49Z [Term] id: GO:0110117 name: positive regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation relationship: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation creation_date: 2018-07-16T18:13:28Z [Term] id: GO:0110118 name: negative regulation of compound eye photoreceptor cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation relationship: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation creation_date: 2018-07-16T18:15:52Z [Term] id: GO:0110122 name: myotube cell migration namespace: biological_process def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742] is_a: GO:0014812 ! muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002372 ! results in movement of myotube relationship: RO:0002565 CL:0002372 ! results in movement of myotube creation_date: 2018-08-22T20:58:09Z [Term] id: GO:0110123 name: regulation of myotube cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0110122 ! regulates myotube cell migration relationship: RO:0002211 GO:0110122 ! regulates myotube cell migration creation_date: 2018-08-22T21:06:53Z [Term] id: GO:0110124 name: positive regulation of myotube cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0110123 ! regulation of myotube cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0110122 ! positively regulates myotube cell migration relationship: RO:0002213 GO:0110122 ! positively regulates myotube cell migration creation_date: 2018-08-22T21:09:38Z [Term] id: GO:0110125 name: negative regulation of myotube cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0110123 ! regulation of myotube cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0110122 ! negatively regulates myotube cell migration relationship: RO:0002212 GO:0110122 ! negatively regulates myotube cell migration creation_date: 2018-08-22T21:12:47Z [Term] id: GO:0110141 name: L-glutamate import into mitochondrion namespace: biological_process def: "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix." [GOC:vw, PMID:30297026] is_a: GO:0015813 ! L-glutamate transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2019-04-24T19:13:46Z [Term] id: GO:0110165 name: cellular anatomical structure namespace: cellular_component def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." [GOC:kmv] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular anatomical entity" EXACT [] is_a: CARO:0000000 ! anatomical entity is_a: GO:0005575 ! cellular_component is_a: UBERON:0000061 ! anatomical structure created_by: kmv creation_date: 2019-08-12T18:01:37Z [Term] id: GO:0120006 name: regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905962 ! regulates glutamatergic neuron differentiation relationship: RO:0002211 GO:1905962 ! regulates glutamatergic neuron differentiation creation_date: 2017-03-01T16:10:27Z [Term] id: GO:0120007 name: negative regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905962 ! negatively regulates glutamatergic neuron differentiation relationship: RO:0002212 GO:1905962 ! negatively regulates glutamatergic neuron differentiation creation_date: 2017-03-01T16:25:50Z [Term] id: GO:0120008 name: positive regulation of glutamatergic neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905962 ! positively regulates glutamatergic neuron differentiation relationship: RO:0002213 GO:1905962 ! positively regulates glutamatergic neuron differentiation creation_date: 2017-03-01T16:35:45Z [Term] id: GO:0120025 name: plasma membrane bounded cell projection namespace: cellular_component def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: BFO:0000051 GO:0098590 ! has part plasma membrane region relationship: BFO:0000051 GO:0098590 ! has part plasma membrane region creation_date: 2017-03-21T17:26:07Z [Term] id: GO:0120031 name: plasma membrane bounded cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] is_a: GO:0030031 ! cell projection assembly is_a: GO:0120036 ! plasma membrane bounded cell projection organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection relationship: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection creation_date: 2017-04-24T23:56:08Z [Term] id: GO:0120032 name: regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0060491 ! regulation of cell projection assembly is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly relationship: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly creation_date: 2017-04-26T04:27:04Z [Term] id: GO:0120033 name: negative regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly relationship: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly creation_date: 2017-04-26T04:34:31Z [Term] id: GO:0120034 name: positive regulation of plasma membrane bounded cell projection assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly relationship: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly creation_date: 2017-04-26T04:34:45Z [Term] id: GO:0120035 name: regulation of plasma membrane bounded cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] is_a: GO:0031344 ! regulation of cell projection organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization relationship: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization creation_date: 2017-04-26T16:02:06Z [Term] id: GO:0120036 name: plasma membrane bounded cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] is_a: GO:0030030 ! cell projection organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection relationship: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection creation_date: 2017-04-26T16:07:02Z [Term] id: GO:0120039 name: plasma membrane bounded cell projection morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] is_a: GO:0048858 ! cell projection morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection relationship: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection creation_date: 2017-04-28T23:39:37Z [Term] id: GO:0120111 name: neuron projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0043005 ! part of neuron projection relationship: BFO:0000050 GO:0043005 ! part of neuron projection creation_date: 2017-11-01T18:58:12Z [Term] id: GO:0120158 name: positive regulation of collagen catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010714 ! positive regulation of collagen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process relationship: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process creation_date: 2018-05-11T16:31:42Z [Term] id: GO:0120178 name: steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln] is_a: GO:0006694 ! steroid biosynthetic process intersection_of: GO:0006694 ! steroid biosynthetic process intersection_of: RO:0004008 CHEBI:26764 ! has primary output relationship: RO:0004008 CHEBI:26764 ! has primary output creation_date: 2019-05-20T22:34:00Z [Term] id: GO:0120186 name: negative regulation of protein localization to chromatin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin relationship: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin creation_date: 2018-07-14T00:19:32Z [Term] id: GO:0120187 name: positive regulation of protein localization to chromatin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin relationship: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin creation_date: 2018-07-14T00:21:28Z [Term] id: GO:0120192 name: tight junction assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl] synonym: "occluding cell junction assembly" EXACT [GOC:rl] synonym: "occluding junction assembly" EXACT [GOC:rl] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0120193 ! tight junction organization intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0070160 ! results in assembly of tight junction relationship: RO:0002588 GO:0070160 ! results in assembly of tight junction creation_date: 2018-08-14T22:48:05Z [Term] id: GO:0120193 name: tight junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:krc, GOC:rl] synonym: "occluding cell junction organization" EXACT [GOC:rl] synonym: "occluding junction organization" EXACT [] is_a: GO:0045216 ! cell-cell junction organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0070160 ! results in organization of tight junction relationship: RO:0002592 GO:0070160 ! results in organization of tight junction creation_date: 2018-08-14T23:05:40Z [Term] id: GO:0120222 name: regulation of blastocyst development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001824 ! regulates blastocyst development relationship: RO:0002211 GO:0001824 ! regulates blastocyst development creation_date: 2020-02-17T19:59:20Z [Term] id: GO:0120223 name: larynx morphogenesis namespace: biological_process def: "The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282] synonym: "laryngeal morphogenesis" EXACT [GOC:krc, PMID:28177282] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001737 ! results in morphogenesis of larynx relationship: BFO:0000050 GO:0120224 ! part of larynx development relationship: RO:0002298 UBERON:0001737 ! results in morphogenesis of larynx creation_date: 2020-02-22T01:42:04Z [Term] id: GO:0120224 name: larynx development namespace: biological_process def: "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282] is_a: GO:0048513 ! animal organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001737 ! results in development of larynx relationship: BFO:0000050 GO:0060541 ! part of respiratory system development relationship: RO:0002296 UBERON:0001737 ! results in development of larynx creation_date: 2020-02-24T17:13:10Z [Term] id: GO:0120229 name: protein localization to motile cilium namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780] synonym: "protein localization to nonmotile primary cilium" RELATED [] is_a: GO:0061512 ! protein localization to cilium intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0031514 ! has target end location motile cilium relationship: RO:0002339 GO:0031514 ! has target end location motile cilium creation_date: 2020-06-05T23:43:04Z [Term] id: GO:0120254 name: olefinic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound metabolic process" EXACT [] synonym: "alkene substituted compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process created_by: krc creation_date: 2020-09-02T23:13:44Z [Term] id: GO:0120255 name: olefinic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] synonym: "alkene substituted compound anabolic process" EXACT [GOC:krc] synonym: "alkene substituted compound anabolism" EXACT [GOC:krc] synonym: "alkene substituted compound biosynthesis" EXACT [GOC:krc] synonym: "alkene substituted compound biosynthetic process" EXACT [GOC:krc] synonym: "alkene substituted compound synthesis" EXACT [GOC:krc] is_a: GO:0009058 ! biosynthetic process is_a: GO:0120254 ! olefinic compound metabolic process created_by: krc creation_date: 2020-09-02T23:30:20Z [Term] id: GO:0120275 name: cerebral blood circulation namespace: biological_process def: "The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:krc, PMID:25397684] synonym: "cerebrum blood circulation" EXACT [] synonym: "telencephelon blood circulation" EXACT [] is_a: GO:0008015 ! blood circulation intersection_of: GO:0008015 ! blood circulation intersection_of: BFO:0000066 UBERON:0001893 ! occurs in telencephalon relationship: BFO:0000066 UBERON:0001893 ! occurs in telencephalon creation_date: 2020-10-20T19:13:51Z [Term] id: GO:0120276 name: regulation of cerebral blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] synonym: "regulation of cerebrum blood circulation" EXACT [] synonym: "regulation of telencephalon blood circulation" EXACT [] is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0120275 ! regulates cerebral blood circulation relationship: RO:0002211 GO:0120275 ! regulates cerebral blood circulation creation_date: 2020-10-21T06:52:22Z [Term] id: GO:0120277 name: positive regulation of cerebral blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] synonym: "activation of cerebral blood circulation" NARROW [] synonym: "positive regulation of cerebrum blood circulation" EXACT [] synonym: "positive regulation of telencephalon blood circulation" EXACT [] synonym: "up regulation of cerebral blood circulation" EXACT [] synonym: "up-regulation of cerebral blood circulation" EXACT [] synonym: "upregulation of cerebral blood circulation" EXACT [] is_a: GO:0120276 ! regulation of cerebral blood circulation is_a: GO:1903524 ! positive regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0120275 ! positively regulates cerebral blood circulation relationship: RO:0002213 GO:0120275 ! positively regulates cerebral blood circulation creation_date: 2020-10-21T06:55:42Z [Term] id: GO:0120278 name: negative regulation of cerebral blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] synonym: "down regulation of cerebral blood circulation" EXACT [] synonym: "down-regulation of cerebral blood circulation" EXACT [] synonym: "downregulation of cerebral blood circulation" EXACT [] synonym: "inhibition of cerebral blood circulation" NARROW [] synonym: "negative regulation of cerebrum blood circulation" EXACT [] synonym: "negative regulation of telencephalon blood circulation" EXACT [] is_a: GO:0120276 ! regulation of cerebral blood circulation is_a: GO:1903523 ! negative regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0120275 ! negatively regulates cerebral blood circulation relationship: RO:0002212 GO:0120275 ! negatively regulates cerebral blood circulation creation_date: 2020-10-21T07:02:05Z [Term] id: GO:0120305 name: regulation of pigmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0043473 ! regulates pigmentation relationship: RO:0002211 GO:0043473 ! regulates pigmentation created_by: krc creation_date: 2021-02-09T19:37:35Z [Term] id: GO:0120331 name: endothelial tube formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824] is_a: GO:0072175 ! epithelial tube formation intersection_of: GO:0035148 ! tube formation intersection_of: RO:0002297 UBERON:0003915 ! results in formation of endothelial tube relationship: BFO:0000050 GO:0061154 ! part of endothelial tube morphogenesis relationship: RO:0002297 UBERON:0003915 ! results in formation of endothelial tube creation_date: 2022-05-25T16:17:59Z [Term] id: GO:0140001 name: morula formation namespace: biological_process def: "The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000085 ! results in formation of morula relationship: RO:0002297 UBERON:0000085 ! results in formation of morula creation_date: 2024-11-12T09:29:56Z [Term] id: GO:0140013 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] subset: goslim_generic synonym: "meiosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle created_by: pg creation_date: 2017-03-23T09:40:00Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic synonym: "mitosis" EXACT [] is_a: GO:0000280 ! nuclear division is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle creation_date: 2017-03-23T14:44:23Z [Term] id: GO:0140029 name: exocytic process namespace: biological_process def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0006887 ! part of exocytosis relationship: BFO:0000050 GO:0006887 ! part of exocytosis creation_date: 2017-05-15T13:20:45Z [Term] id: GO:0140039 name: cell-cell adhesion in response to extracellular stimulus namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911] is_a: GO:0098609 ! cell-cell adhesion intersection_of: GO:0098609 ! cell-cell adhesion intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus creation_date: 2017-05-24T11:37:30Z [Term] id: GO:0140053 name: mitochondrial gene expression namespace: biological_process def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308] subset: goslim_generic subset: goslim_pombe is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota creation_date: 2017-06-26T10:57:45Z [Term] id: GO:0140056 name: organelle localization by membrane tethering namespace: biological_process def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684] subset: goslim_pombe is_a: GO:0022406 ! membrane docking is_a: GO:0051640 ! organelle localization creation_date: 2017-06-27T09:58:51Z [Term] id: GO:0140096 name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein created_by: pg creation_date: 2017-09-14T10:32:59Z [Term] id: GO:0140097 name: catalytic activity, acting on DNA namespace: molecular_function def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:16991 ! has primary input relationship: RO:0004009 CHEBI:16991 ! has primary input creation_date: 2017-09-14T12:03:51Z [Term] id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic subset: goslim_prokaryote is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid creation_date: 2017-09-14T12:05:21Z [Term] id: GO:0140103 name: catalytic activity, acting on a glycoprotein namespace: molecular_function def: "Catalysis of a biochemical reaction in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0140096 ! catalytic activity, acting on a protein intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input creation_date: 2017-09-15T19:27:54Z [Term] id: GO:0140112 name: extracellular vesicle biogenesis namespace: biological_process def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435] synonym: "extracellular vesicle assembly" EXACT [] is_a: GO:0044085 ! cellular component biogenesis creation_date: 2017-10-23T11:53:42Z [Term] id: GO:0140115 name: export across plasma membrane namespace: biological_process def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane creation_date: 2017-10-24T14:38:16Z [Term] id: GO:0140131 name: positive regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis." [PMID:19255442] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000403 ! positive regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048247 ! positively regulates lymphocyte chemotaxis relationship: RO:0002213 GO:0048247 ! positively regulates lymphocyte chemotaxis creation_date: 2017-11-02T10:26:40Z [Term] id: GO:0140231 name: anterograde axonal transport of neurotransmitter receptor complex namespace: biological_process def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963] subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:0099641 ! anterograde axonal protein transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex creation_date: 2018-07-09T09:41:37Z [Term] id: GO:0140236 name: translation at presynapse namespace: biological_process def: "Translation that occurs at the presynapse." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2018-07-13T13:00:33Z [Term] id: GO:0140237 name: translation at presynapse, modulating chemical synaptic transmission namespace: biological_process def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140236 ! translation at presynapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission creation_date: 2018-07-13T13:07:23Z [Term] id: GO:0140238 name: presynaptic endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006897 ! endocytosis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099003 ! vesicle-mediated transport in synapse intersection_of: GO:0006897 ! endocytosis intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2018-07-15T07:33:55Z [Term] id: GO:0140239 name: postsynaptic endocytosis namespace: biological_process def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006897 ! endocytosis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099003 ! vesicle-mediated transport in synapse intersection_of: GO:0006897 ! endocytosis intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2018-07-15T07:38:27Z [Term] id: GO:0140241 name: translation at synapse namespace: biological_process def: "Translation that occurs at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006412 ! translation intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa creation_date: 2018-07-15T09:23:12Z [Term] id: GO:0140242 name: translation at postsynapse namespace: biological_process def: "Translation that occurs at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140241 ! translation at synapse intersection_of: GO:0006412 ! translation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2018-07-15T09:26:27Z [Term] id: GO:0140243 name: regulation of translation at synapse namespace: biological_process def: "Any process that regulates translation occurring at the synapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa creation_date: 2018-07-15T09:38:26Z [Term] id: GO:0140244 name: regulation of translation at presynapse namespace: biological_process def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2018-07-15T09:38:33Z [Term] id: GO:0140245 name: regulation of translation at postsynapse namespace: biological_process def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140243 ! regulation of translation at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0006412 ! regulates translation relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2018-07-15T09:38:54Z [Term] id: GO:0140246 name: protein catabolic process at synapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0030163 ! protein catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0004009 CHEBI:36080 ! has primary input protein creation_date: 2018-07-15T10:12:51Z [Term] id: GO:0140247 name: protein catabolic process at presynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2018-07-15T10:23:49Z [Term] id: GO:0140249 name: protein catabolic process at postsynapse namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140246 ! protein catabolic process at synapse intersection_of: GO:0009056 ! catabolic process intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2018-07-15T10:25:04Z [Term] id: GO:0140250 name: regulation protein catabolic process at synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0045202 ! occurs in synapse relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0004009 CHEBI:36080 ! has primary input protein creation_date: 2018-07-15T10:34:56Z [Term] id: GO:0140251 name: regulation protein catabolic process at presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098793 ! occurs in presynapse creation_date: 2018-07-15T10:35:39Z [Term] id: GO:0140252 name: regulation protein catabolic process at postsynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563] comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. subset: goslim_synapse is_a: GO:0140250 ! regulation protein catabolic process at synapse intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse creation_date: 2018-07-15T10:35:56Z [Term] id: GO:0140253 name: cell-cell fusion namespace: biological_process def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion] synonym: "cell cell fusion" EXACT [] synonym: "cell fusion" BROAD [] is_a: GO:0009987 ! cellular process relationship: BFO:0000051 GO:0045026 ! has part plasma membrane fusion creation_date: 2018-08-13T18:38:18Z [Term] id: GO:0140272 name: exogenous protein binding namespace: molecular_function def: "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068] comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant. is_a: GO:0005515 ! protein binding created_by: pg creation_date: 2018-10-01T10:03:21Z [Term] id: GO:0140297 name: DNA-binding transcription factor binding namespace: molecular_function def: "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] synonym: "activating transcription factor binding" RELATED [] synonym: "repressing transcription factor binding" RELATED [] synonym: "transcription activator binding" RELATED [] is_a: GO:0008134 ! transcription factor binding creation_date: 2018-11-28T12:48:20Z [Term] id: GO:0140318 name: protein transporter activity namespace: molecular_function def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. synonym: "protein carrier activity" RELATED [] synonym: "protein transport chaperone" RELATED [] xref: Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome" xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" is_a: GO:0005215 ! transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0004009 PR:000000001 ! has primary input protein relationship: RO:0004009 PR:000000001 ! has primary input protein creation_date: 2019-04-01T10:41:38Z [Term] id: GO:0140352 name: export from cell namespace: biological_process def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] synonym: "efflux" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure relationship: RO:0002339 GO:0005576 ! has target end location extracellular region created_by: pg creation_date: 2019-05-22T11:20:45Z [Term] id: GO:0140353 name: lipid export from cell namespace: biological_process def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg] synonym: "lipid efflux" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid creation_date: 2019-05-22T11:33:07Z [Term] id: GO:0140354 name: lipid import into cell namespace: biological_process def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg] synonym: "lipid uptake" BROAD [] is_a: GO:0006869 ! lipid transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid relationship: RO:0002338 GO:0005576 ! has target start location extracellular region relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure creation_date: 2019-05-22T11:38:15Z [Term] id: GO:0140375 name: immune receptor activity namespace: molecular_function def: "Receiving a signal and transmitting it in a cell to initiate an immune response." [PMID:31415752, Wikipedia:Immune_receptor] is_a: GO:0038023 ! signaling receptor activity creation_date: 2019-10-18T14:11:15Z [Term] id: GO:0140513 name: nuclear protein-containing complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] subset: gocheck_do_not_annotate synonym: "nuclear complex" EXACT [] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0005634 ! part of nucleus created_by: pg creation_date: 2020-09-09T05:12:38Z [Term] id: GO:0140546 name: defense response to symbiont namespace: biological_process def: "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg] is_a: GO:0098542 ! defense response to other organism created_by: pg creation_date: 2020-11-11T17:19:06Z [Term] id: GO:0140572 name: vacuole fission namespace: biological_process def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0005773 ! results in fission of vacuole relationship: GOREL:0002004 GO:0005773 ! results in fission of vacuole created_by: pg creation_date: 2021-01-04T10:17:58Z [Term] id: GO:0140640 name: catalytic activity, acting on a nucleic acid namespace: molecular_function def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid creation_date: 2021-05-11T06:31:07Z [Term] id: GO:0140657 name: ATP-dependent activity namespace: molecular_function def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_prokaryote subset: goslim_yeast synonym: "ATP hydrolysis-dependent activity" EXACT [] synonym: "ATPase activity" EXACT [] synonym: "ATPase activity, coupled" EXACT [] synonym: "ATPase-dependent activity" EXACT [] is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity relationship: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity created_by: pg creation_date: 2021-06-15T07:35:06Z [Term] id: GO:0140694 name: membraneless organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] synonym: "non-membrane-bounded organelle assembly" EXACT [] synonym: "non-membrane-bounded organelle formation" EXACT [] synonym: "non-membrane-enclosed organelle assembly" EXACT [] synonym: "non-membrane-enclosed organelle formation" EXACT [] is_a: GO:0070925 ! organelle assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle relationship: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle creation_date: 2021-08-09T15:30:06Z [Term] id: GO:0140820 name: cytosol to Golgi apparatus transport namespace: biological_process def: "The directed movement of substances from the cytosol into the Golgi apparatus of a cell." [PMID:28373556] is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus creation_date: 2022-05-16T06:59:22Z [Term] id: GO:0140899 name: plastid gene expression namespace: biological_process def: "The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:28377785] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid relationship: BFO:0000066 GO:0009536 ! occurs in plastid creation_date: 2022-08-17T10:34:35Z [Term] id: GO:0141187 name: nucleic acid biosynthetic process namespace: biological_process def: "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:33696 ! has primary output nucleic acid relationship: RO:0004008 CHEBI:33696 ! has primary output nucleic acid created_by: pg creation_date: 2024-03-25T07:33:40Z [Term] id: GO:0141188 name: nucleic acid catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators] comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. subset: gocheck_do_not_annotate is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid creation_date: 2024-03-25T07:35:06Z [Term] id: GO:0150031 name: regulation of protein localization to lysosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061462 ! regulates protein localization to lysosome relationship: RO:0002211 GO:0061462 ! regulates protein localization to lysosome creation_date: 2018-02-06T17:07:03Z [Term] id: GO:0150032 name: positive regulation of protein localization to lysosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc] is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061462 ! positively regulates protein localization to lysosome relationship: RO:0002213 GO:0061462 ! positively regulates protein localization to lysosome creation_date: 2018-02-06T17:11:02Z [Term] id: GO:0150033 name: negative regulation of protein localization to lysosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061462 ! negatively regulates protein localization to lysosome relationship: RO:0002212 GO:0061462 ! negatively regulates protein localization to lysosome creation_date: 2018-02-06T17:14:16Z [Term] id: GO:0150052 name: regulation of postsynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854] subset: goslim_synapse is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099175 ! regulation of postsynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099068 ! regulates postsynapse assembly relationship: RO:0002211 GO:0099068 ! regulates postsynapse assembly creation_date: 2018-05-08T16:38:55Z [Term] id: GO:0150063 name: visual system development namespace: biological_process def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727] synonym: "optic pathway development" RELATED [] synonym: "visual pathway development" RELATED [] is_a: GO:0048880 ! sensory system development creation_date: 2018-07-23T10:31:58Z [Term] id: GO:0150076 name: neuroinflammatory response namespace: biological_process def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] synonym: "nerve tissue inflammatory response" EXACT [] synonym: "nervous tissue inflammatory response" EXACT [] synonym: "neural tissue inflammatory response" EXACT [] is_a: GO:0006954 ! inflammatory response creation_date: 2018-07-26T12:25:34Z [Term] id: GO:0150077 name: regulation of neuroinflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150076 ! regulates neuroinflammatory response relationship: RO:0002211 GO:0150076 ! regulates neuroinflammatory response creation_date: 2018-07-26T12:32:18Z [Term] id: GO:0150078 name: positive regulation of neuroinflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc] is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150076 ! positively regulates neuroinflammatory response relationship: RO:0002213 GO:0150076 ! positively regulates neuroinflammatory response creation_date: 2018-07-26T12:35:50Z [Term] id: GO:0150079 name: negative regulation of neuroinflammatory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423] is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150076 ! negatively regulates neuroinflammatory response relationship: RO:0002212 GO:0150076 ! negatively regulates neuroinflammatory response creation_date: 2018-07-26T12:38:08Z [Term] id: GO:0150098 name: glial cell-neuron signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] synonym: "glia-neuron signaling" EXACT [] synonym: "glia-neuron signalling" EXACT [] synonym: "glia-neurone signaling" EXACT [] synonym: "glia-neurone signalling" EXACT [] synonym: "glial cell- neuron signalling" EXACT [] synonym: "glial cell-neurone signalling" EXACT [] synonym: "glial cell-neurone singaling" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000125 ! has start location glial cell intersection_of: RO:0002232 CL:0000540 ! has end location neuron relationship: RO:0002231 CL:0000125 ! has start location glial cell relationship: RO:0002232 CL:0000540 ! has end location neuron creation_date: 2018-12-17T12:28:09Z [Term] id: GO:0150099 name: neuron-glial cell signaling namespace: biological_process def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] synonym: "neuron-glia signaling" EXACT [] synonym: "neuron-glia signalling" EXACT [] synonym: "neuron-glial cell signalling" EXACT [] synonym: "neurone-glia signaling" EXACT [] synonym: "neurone-glia signalling" EXACT [] synonym: "neurone-glial cell signaling" EXACT [] synonym: "neurone-glial cell signalling" EXACT [] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000540 ! has start location neuron intersection_of: RO:0002232 CL:0000125 ! has end location glial cell relationship: RO:0002231 CL:0000540 ! has start location neuron relationship: RO:0002232 CL:0000125 ! has end location glial cell creation_date: 2018-12-17T12:30:12Z [Term] id: GO:0150102 name: negative regulation of monocyte activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation." [GOC:aruk, PMID:15597323] synonym: "repression of monocyte activation" EXACT [] is_a: GO:0002695 ! negative regulation of leukocyte activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042117 ! negatively regulates monocyte activation relationship: RO:0002212 GO:0042117 ! negatively regulates monocyte activation creation_date: 2019-04-26T20:01:24Z [Term] id: GO:0150105 name: protein localization to cell-cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:1902414 ! protein localization to cell junction intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005911 ! has target end location cell-cell junction relationship: RO:0002339 GO:0005911 ! has target end location cell-cell junction creation_date: 2019-06-11T11:00:18Z [Term] id: GO:0150106 name: regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction relationship: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction creation_date: 2019-06-11T11:17:15Z [Term] id: GO:0150107 name: positive regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction relationship: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction creation_date: 2019-06-11T11:23:58Z [Term] id: GO:0150111 name: regulation of transepithelial transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915] is_a: GO:0051049 ! regulation of transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070633 ! regulates transepithelial transport relationship: RO:0002211 GO:0070633 ! regulates transepithelial transport creation_date: 2019-09-15T07:16:49Z [Term] id: GO:0150119 name: negative regulation of protein localization to cell-cell junction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc] synonym: "negative regulation of protein localisation to cell-cell junction" EXACT [] is_a: GO:0150106 ! regulation of protein localization to cell-cell junction is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction relationship: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction creation_date: 2019-11-21T13:53:34Z [Term] id: GO:0150146 name: cell junction disassembly namespace: biological_process def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0034330 ! cell junction organization intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0030054 ! results in disassembly of cell junction relationship: RO:0002590 GO:0030054 ! results in disassembly of cell junction creation_date: 2019-12-08T11:12:13Z [Term] id: GO:0150147 name: cell-cell junction disassembly namespace: biological_process def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267] is_a: GO:0045216 ! cell-cell junction organization is_a: GO:0150146 ! cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction relationship: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction creation_date: 2019-12-08T11:16:14Z [Term] id: GO:0160038 name: somatic sensory system development namespace: biological_process def: "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain." [PMID:25832476, PMID:31399790] synonym: "somatosensory system development" EXACT [] is_a: GO:0048880 ! sensory system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003942 ! results in development of somatosensory system relationship: RO:0002296 UBERON:0003942 ! results in development of somatosensory system creation_date: 2022-07-07T16:49:26Z [Term] id: GO:0160043 name: catecholamine secretion, neurotransmission namespace: biological_process def: "The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter." [PMID:10191060] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0007269 ! neurotransmitter secretion intersection_of: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2022-08-17T00:36:44Z [Term] id: GO:0160048 name: craniofacial suture closure namespace: biological_process def: "The process of fusing together the edges of a craniofacial suture." [PMID:33842480] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0060349 ! bone morphogenesis intersection_of: RO:0012008 UBERON:0009198 ! results in fusion of craniofacial suture relationship: RO:0012008 UBERON:0009198 ! results in fusion of craniofacial suture creation_date: 2022-08-19T23:18:54Z [Term] id: GO:0160093 name: chordate pharynx development namespace: biological_process def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903] is_a: GO:0060465 ! pharynx development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx relationship: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx creation_date: 2023-08-29T21:05:28Z [Term] id: GO:0170033 name: L-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an L-amino acid." [GOC:edw] synonym: "L-alpha-amino acid metabolism" EXACT [] synonym: "L-amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:59869 ! has primary input or output L-alpha-amino acid zwitterion relationship: RO:0004007 CHEBI:59869 ! has primary input or output L-alpha-amino acid zwitterion created_by: ew creation_date: 2023-11-20T23:41:23Z [Term] id: GO:0170034 name: L-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw] synonym: "L-amino acid anabolism" EXACT [] synonym: "L-amino acid biosynthesis" EXACT [] synonym: "L-amino acid formation" EXACT [] synonym: "L-amino acid synthesis" EXACT [] is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:59869 ! has primary output L-alpha-amino acid zwitterion relationship: RO:0004008 CHEBI:59869 ! has primary output L-alpha-amino acid zwitterion created_by: ew creation_date: 2023-11-20T23:42:06Z [Term] id: GO:0170035 name: L-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an L-amino acid." [GOC:edw] synonym: "L-amino acid breakdown" EXACT [] synonym: "L-amino acid catabolism" EXACT [] synonym: "L-amino acid degradation" EXACT [] is_a: GO:0170033 ! L-amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion creation_date: 2023-11-21T00:55:07Z [Term] id: GO:0170036 name: import into the mitochondrion namespace: biological_process def: "The directed movement of substances from the cytosol into the mitochondrion." [GOC:ew] is_a: GO:1990542 ! mitochondrial transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane relationship: RO:0002338 GO:0005829 ! has target start location cytosol relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix creation_date: 2023-11-30T20:56:49Z [Term] id: GO:0170037 name: export from the mitochondrion namespace: biological_process def: "The directed movement of substances from the mitochondrion to the cytosol." [GOC:ew] is_a: GO:1990542 ! mitochondrial transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane relationship: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix relationship: RO:0002339 GO:0005829 ! has target end location cytosol creation_date: 2023-11-30T21:03:28Z [Term] id: GO:0170038 name: proteinogenic amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid anabolism" EXACT [] synonym: "proteinogenic amino acid biosynthesis" EXACT [] synonym: "proteinogenic amino acid formation" EXACT [] synonym: "proteinogenic amino acid synthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:83813 ! has primary output proteinogenic amino acid relationship: RO:0004008 CHEBI:83813 ! has primary output proteinogenic amino acid created_by: ew creation_date: 2023-12-18T16:28:19Z [Term] id: GO:0170039 name: proteinogenic amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid metabolism" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:83813 ! has primary input or output proteinogenic amino acid relationship: RO:0004007 CHEBI:83813 ! has primary input or output proteinogenic amino acid created_by: ew creation_date: 2023-12-18T17:31:08Z [Term] id: GO:0170040 name: proteinogenic amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew] synonym: "proteinogenic amino acid breakdown" EXACT [] synonym: "proteinogenic amino acid catabolism" EXACT [] synonym: "proteinogenic amino acid degradation" EXACT [] is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0170039 ! proteinogenic amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:83813 ! has primary input proteinogenic amino acid relationship: RO:0004009 CHEBI:83813 ! has primary input proteinogenic amino acid creation_date: 2023-12-18T17:41:14Z [Term] id: GO:0170041 name: non-proteinogenic amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-proteingenic amino acids." [GOC:ew] synonym: "non-proteinogenic amino acid metabolism" EXACT [] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:83820 ! has primary input or output non-proteinogenic amino acid relationship: RO:0004007 CHEBI:83820 ! has primary input or output non-proteinogenic amino acid creation_date: 2023-12-18T17:57:55Z [Term] id: GO:0170043 name: non-proteinogenic amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids." [GOC:ew] synonym: "non-proteinogenic amino acid anabolism" EXACT [] synonym: "non-proteinogenic amino acid formation" EXACT [] synonym: "non-proteinogenic amino acid synthesis" EXACT [] synonym: "non-proteinogenic biosynthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:83820 ! has primary output non-proteinogenic amino acid relationship: RO:0004008 CHEBI:83820 ! has primary output non-proteinogenic amino acid creation_date: 2023-12-18T19:03:08Z [Term] id: GO:0170044 name: non-proteinogenic amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids." [GOC:ew] synonym: "non-proteinogenic amino acid breakdown" EXACT [] synonym: "non-proteinogenic amino acid catabolism" EXACT [] synonym: "non-proteinogenic amino acid degradation" EXACT [] is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:83820 ! has primary input non-proteinogenic amino acid relationship: RO:0004009 CHEBI:83820 ! has primary input non-proteinogenic amino acid creation_date: 2023-12-18T19:27:05Z [Term] id: GO:0170055 name: lipid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a lipid from one side of a membrane to the other." [GOC:curators] subset: gocheck_do_not_annotate is_a: GO:0005319 ! lipid transporter activity is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid creation_date: 2024-03-15T18:47:58Z [Term] id: GO:1900006 name: positive regulation of dendrite development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie] synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie] is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0016358 ! positively regulates dendrite development relationship: RO:0002213 GO:0016358 ! positively regulates dendrite development creation_date: 2012-01-09T10:41:31Z [Term] id: GO:1900015 name: regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002534 ! regulates cytokine production involved in inflammatory response relationship: RO:0002211 GO:0002534 ! regulates cytokine production involved in inflammatory response creation_date: 2012-01-11T09:34:27Z [Term] id: GO:1900016 name: negative regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002534 ! negatively regulates cytokine production involved in inflammatory response relationship: RO:0002212 GO:0002534 ! negatively regulates cytokine production involved in inflammatory response creation_date: 2012-01-11T09:34:31Z [Term] id: GO:1900017 name: positive regulation of cytokine production involved in inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002534 ! positively regulates cytokine production involved in inflammatory response relationship: RO:0002213 GO:0002534 ! positively regulates cytokine production involved in inflammatory response creation_date: 2012-01-11T09:34:35Z [Term] id: GO:1900115 name: extracellular regulation of signal transduction namespace: biological_process def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0009966 ! regulation of signal transduction intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region creation_date: 2012-02-22T10:21:48Z [Term] id: GO:1900116 name: extracellular negative regulation of signal transduction namespace: biological_process def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie] synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf] synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie] synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900115 ! extracellular regulation of signal transduction intersection_of: GO:0009968 ! negative regulation of signal transduction intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region creation_date: 2012-02-22T10:27:56Z [Term] id: GO:1900117 name: regulation of execution phase of apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis relationship: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis creation_date: 2012-02-22T11:26:20Z [Term] id: GO:1900118 name: negative regulation of execution phase of apoptosis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis relationship: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis creation_date: 2012-02-22T11:26:24Z [Term] id: GO:1900119 name: positive regulation of execution phase of apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1900117 ! regulation of execution phase of apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis relationship: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis creation_date: 2012-02-22T11:26:27Z [Term] id: GO:1900120 name: regulation of receptor binding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0043393 ! regulation of protein binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005102 ! regulates signaling receptor binding relationship: RO:0002211 GO:0005102 ! regulates signaling receptor binding creation_date: 2012-02-22T11:40:53Z [Term] id: GO:1900121 name: negative regulation of receptor binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie] synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie] synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie] synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie] is_a: GO:0032091 ! negative regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0005102 ! negatively regulates signaling receptor binding relationship: RO:0002212 GO:0005102 ! negatively regulates signaling receptor binding creation_date: 2012-02-22T11:40:57Z [Term] id: GO:1900122 name: positive regulation of receptor binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "activation of receptor binding" NARROW [GOC:TermGenie] synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie] synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie] is_a: GO:0032092 ! positive regulation of protein binding is_a: GO:1900120 ! regulation of receptor binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0005102 ! positively regulates signaling receptor binding relationship: RO:0002213 GO:0005102 ! positively regulates signaling receptor binding creation_date: 2012-02-22T11:41:00Z [Term] id: GO:1900125 name: regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process relationship: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process creation_date: 2012-02-23T01:09:21Z [Term] id: GO:1900126 name: negative regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process relationship: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process creation_date: 2012-02-23T01:09:29Z [Term] id: GO:1900127 name: positive regulation of hyaluronan biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie] synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process relationship: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process creation_date: 2012-02-23T01:09:33Z [Term] id: GO:1900131 name: negative regulation of lipid binding namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] subset: gocheck_do_not_annotate synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie] synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie] synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie] is_a: GO:0051100 ! negative regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008289 ! negatively regulates lipid binding relationship: RO:0002212 GO:0008289 ! negatively regulates lipid binding creation_date: 2012-02-23T04:05:07Z [Term] id: GO:1900141 name: regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:0034350 ! regulation of glial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097252 ! regulates oligodendrocyte apoptotic process relationship: RO:0002211 GO:0097252 ! regulates oligodendrocyte apoptotic process creation_date: 2012-03-06T10:22:45Z [Term] id: GO:1900142 name: negative regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] is_a: GO:0034351 ! negative regulation of glial cell apoptotic process is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097252 ! negatively regulates oligodendrocyte apoptotic process relationship: RO:0002212 GO:0097252 ! negatively regulates oligodendrocyte apoptotic process creation_date: 2012-03-06T10:22:50Z [Term] id: GO:1900143 name: positive regulation of oligodendrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034352 ! positive regulation of glial cell apoptotic process is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097252 ! positively regulates oligodendrocyte apoptotic process relationship: RO:0002213 GO:0097252 ! positively regulates oligodendrocyte apoptotic process creation_date: 2012-03-06T10:22:54Z [Term] id: GO:1900147 name: regulation of Schwann cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036135 ! regulates Schwann cell migration relationship: RO:0002211 GO:0036135 ! regulates Schwann cell migration creation_date: 2012-03-06T04:14:50Z [Term] id: GO:1900148 name: negative regulation of Schwann cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie] is_a: GO:1900147 ! regulation of Schwann cell migration is_a: GO:1903976 ! negative regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036135 ! negatively regulates Schwann cell migration relationship: RO:0002212 GO:0036135 ! negatively regulates Schwann cell migration creation_date: 2012-03-06T04:14:55Z [Term] id: GO:1900149 name: positive regulation of Schwann cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie] is_a: GO:1900147 ! regulation of Schwann cell migration is_a: GO:1903977 ! positive regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036135 ! positively regulates Schwann cell migration relationship: RO:0002213 GO:0036135 ! positively regulates Schwann cell migration creation_date: 2012-03-06T04:14:58Z [Term] id: GO:1900150 name: regulation of defense response to fungus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006] synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie] synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie] synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie] synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol] synonym: "regulation of defense response to fungus, incompatible interaction" NARROW [] synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol] synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol] synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0050832 ! regulates defense response to fungus relationship: RO:0002211 GO:0050832 ! regulates defense response to fungus creation_date: 2012-03-06T10:00:16Z [Term] id: GO:1900160 name: plastid chromosome packaging namespace: biological_process def: "A process in which plastidial DNA and associated proteins organize into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie] synonym: "DNA organization in plastid" EXACT [GOC:TermGenie] synonym: "plastid DNA packaging" EXACT [] synonym: "plastidial DNA packaging" EXACT [GOC:emb] is_a: GO:0051276 ! chromosome organization intersection_of: GO:0051276 ! chromosome organization intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid relationship: BFO:0000066 GO:0009536 ! occurs in plastid creation_date: 2012-03-08T10:51:50Z [Term] id: GO:1900180 name: regulation of protein localization to nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034504 ! regulates protein localization to nucleus relationship: RO:0002211 GO:0034504 ! regulates protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:44Z [Term] id: GO:1900181 name: negative regulation of protein localization to nucleus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus relationship: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus creation_date: 2012-03-12T01:23:48Z [Term] id: GO:1900182 name: positive regulation of protein localization to nucleus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus relationship: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus creation_date: 2012-03-12T01:23:52Z [Term] id: GO:1900193 name: regulation of oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] is_a: GO:1903429 ! regulation of cell maturation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001556 ! regulates oocyte maturation relationship: RO:0002211 GO:0001556 ! regulates oocyte maturation creation_date: 2012-03-19T09:41:18Z [Term] id: GO:1900194 name: negative regulation of oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903430 ! negative regulation of cell maturation is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation relationship: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation creation_date: 2012-03-19T09:41:27Z [Term] id: GO:1900195 name: positive regulation of oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:1900193 ! regulation of oocyte maturation is_a: GO:1903431 ! positive regulation of cell maturation is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001556 ! positively regulates oocyte maturation relationship: RO:0002213 GO:0001556 ! positively regulates oocyte maturation creation_date: 2012-03-19T09:41:35Z [Term] id: GO:1900247 name: regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] is_a: GO:0006448 ! regulation of translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002182 ! regulates cytoplasmic translational elongation relationship: RO:0002211 GO:0002182 ! regulates cytoplasmic translational elongation creation_date: 2012-04-03T05:07:02Z [Term] id: GO:1900248 name: negative regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:1900247 ! regulation of cytoplasmic translational elongation is_a: GO:2000766 ! negative regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002182 ! negatively regulates cytoplasmic translational elongation relationship: RO:0002212 GO:0002182 ! negatively regulates cytoplasmic translational elongation creation_date: 2012-04-03T05:07:14Z [Term] id: GO:1900249 name: positive regulation of cytoplasmic translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:1900247 ! regulation of cytoplasmic translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002182 ! positively regulates cytoplasmic translational elongation relationship: RO:0002213 GO:0002182 ! positively regulates cytoplasmic translational elongation creation_date: 2012-04-03T05:07:24Z [Term] id: GO:1900366 name: negative regulation of defense response to insect namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie] synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie] synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "susceptibility to insect" RELATED [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:2000068 ! regulation of defense response to insect intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002213 ! negatively regulates defense response to insect relationship: RO:0002212 GO:0002213 ! negatively regulates defense response to insect creation_date: 2012-04-12T04:44:00Z [Term] id: GO:1900367 name: positive regulation of defense response to insect namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] synonym: "activation of defense response to insect" NARROW [GOC:TermGenie] synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie] synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie] synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:2000068 ! regulation of defense response to insect intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002213 ! positively regulates defense response to insect relationship: RO:0002213 GO:0002213 ! positively regulates defense response to insect creation_date: 2012-04-12T04:44:10Z [Term] id: GO:1900376 name: regulation of secondary metabolite biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044550 ! regulates secondary metabolite biosynthetic process relationship: RO:0002211 GO:0044550 ! regulates secondary metabolite biosynthetic process created_by: di creation_date: 2012-04-17T01:55:23Z [Term] id: GO:1900407 name: regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0080135 ! regulation of cellular response to stress is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034599 ! regulates cellular response to oxidative stress relationship: RO:0002211 GO:0034599 ! regulates cellular response to oxidative stress creation_date: 2012-04-20T03:30:52Z [Term] id: GO:1900408 name: negative regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie] synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1902883 ! negative regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034599 ! negatively regulates cellular response to oxidative stress relationship: RO:0002212 GO:0034599 ! negatively regulates cellular response to oxidative stress creation_date: 2012-04-20T03:31:05Z [Term] id: GO:1900409 name: positive regulation of cellular response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie] synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900407 ! regulation of cellular response to oxidative stress is_a: GO:1902884 ! positive regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034599 ! positively regulates cellular response to oxidative stress relationship: RO:0002213 GO:0034599 ! positively regulates cellular response to oxidative stress creation_date: 2012-04-20T03:31:16Z [Term] id: GO:1900449 name: regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007215 ! regulates glutamate receptor signaling pathway relationship: RO:0002211 GO:0007215 ! regulates glutamate receptor signaling pathway creation_date: 2012-04-27T03:45:43Z [Term] id: GO:1900450 name: negative regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007215 ! negatively regulates glutamate receptor signaling pathway relationship: RO:0002212 GO:0007215 ! negatively regulates glutamate receptor signaling pathway creation_date: 2012-04-27T03:45:53Z [Term] id: GO:1900451 name: positive regulation of glutamate receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007215 ! positively regulates glutamate receptor signaling pathway relationship: RO:0002213 GO:0007215 ! positively regulates glutamate receptor signaling pathway creation_date: 2012-04-27T03:46:03Z [Term] id: GO:1900619 name: acetate ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie] synonym: "acetate ester metabolism" EXACT [GOC:TermGenie] synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622] synonym: "acetyl ester metabolism" EXACT [CHEBI:47622] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:47622 ! has primary input or output relationship: RO:0004007 CHEBI:47622 ! has primary input or output creation_date: 2012-05-16T12:29:51Z [Term] id: GO:1900620 name: acetate ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596] synonym: "acetate ester anabolism" EXACT [GOC:TermGenie] synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie] synonym: "acetate ester formation" EXACT [GOC:TermGenie] synonym: "acetate ester synthesis" EXACT [GOC:TermGenie] synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622] synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622] is_a: GO:0009058 ! biosynthetic process is_a: GO:1900619 ! acetate ester metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:47622 ! has primary output relationship: RO:0004008 CHEBI:47622 ! has primary output creation_date: 2012-05-16T12:30:12Z [Term] id: GO:1900923 name: regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "regulation of glycine import" BROAD [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0032890 ! regulation of organic acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903804 ! regulates glycine import across plasma membrane relationship: RO:0002211 GO:1903804 ! regulates glycine import across plasma membrane creation_date: 2012-06-13T07:40:11Z [Term] id: GO:1900924 name: negative regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "down regulation of glycine import" EXACT [GOC:TermGenie] synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "downregulation of glycine import" EXACT [GOC:TermGenie] synonym: "inhibition of glycine import" NARROW [GOC:TermGenie] synonym: "negative regulation of glycine import" BROAD [] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903804 ! negatively regulates glycine import across plasma membrane relationship: RO:0002212 GO:1903804 ! negatively regulates glycine import across plasma membrane creation_date: 2012-06-13T07:40:32Z [Term] id: GO:1900925 name: positive regulation of glycine import across plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie] synonym: "activation of glycine import" NARROW [GOC:TermGenie] synonym: "positive regulation of glycine import" BROAD [] synonym: "up regulation of glycine import" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "upregulation of glycine import" EXACT [GOC:TermGenie] is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903804 ! positively regulates glycine import across plasma membrane relationship: RO:0002213 GO:1903804 ! positively regulates glycine import across plasma membrane creation_date: 2012-06-13T07:40:40Z [Term] id: GO:1901031 name: regulation of response to reactive oxygen species namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "regulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000302 ! regulates response to reactive oxygen species relationship: RO:0002211 GO:0000302 ! regulates response to reactive oxygen species creation_date: 2012-06-20T07:47:06Z [Term] id: GO:1901032 name: negative regulation of response to reactive oxygen species namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie] synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie] synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie] synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie] synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie] synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1902883 ! negative regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0000302 ! negatively regulates response to reactive oxygen species relationship: RO:0002212 GO:0000302 ! negatively regulates response to reactive oxygen species creation_date: 2012-06-20T07:47:28Z [Term] id: GO:1901033 name: positive regulation of response to reactive oxygen species namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "activation of response to AOS" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie] synonym: "activation of response to ROI" EXACT [GOC:TermGenie] synonym: "activation of response to ROS" EXACT [GOC:TermGenie] synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie] synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie] synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie] synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie] synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1902884 ! positive regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0000302 ! positively regulates response to reactive oxygen species relationship: RO:0002213 GO:0000302 ! positively regulates response to reactive oxygen species creation_date: 2012-06-20T07:47:35Z [Term] id: GO:1901135 name: carbohydrate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] subset: goslim_agr subset: goslim_generic subset: goslim_mouse subset: goslim_prokaryote synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:63299 ! has primary input or output carbohydrate derivative relationship: RO:0004007 CHEBI:63299 ! has primary input or output carbohydrate derivative creation_date: 2012-07-12T04:05:09Z [Term] id: GO:1901136 name: carbohydrate derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative creation_date: 2012-07-12T04:05:31Z [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process is_a: GO:1901135 ! carbohydrate derivative metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:63299 ! has primary output carbohydrate derivative relationship: RO:0004008 CHEBI:63299 ! has primary output carbohydrate derivative creation_date: 2012-07-12T04:05:39Z [Term] id: GO:1901148 name: gene expression involved in extracellular matrix organization namespace: biological_process def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558] synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf] synonym: "extracellular matrix protein production" RELATED [GOC:pg] is_a: GO:0010467 ! gene expression intersection_of: GO:0010467 ! gene expression intersection_of: BFO:0000050 GO:0030198 ! part of extracellular matrix organization relationship: BFO:0000050 GO:0030198 ! part of extracellular matrix organization creation_date: 2012-07-16T03:29:30Z [Term] id: GO:1901161 name: primary amino compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie] synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound degradation" EXACT [GOC:TermGenie] is_a: GO:0009056 ! catabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:50994 ! has primary input primary amino compound relationship: RO:0004009 CHEBI:50994 ! has primary input primary amino compound creation_date: 2012-07-18T04:45:06Z [Term] id: GO:1901162 name: primary amino compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie] synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie] synonym: "primary amino compound formation" EXACT [GOC:TermGenie] synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:50994 ! has primary output primary amino compound relationship: RO:0004008 CHEBI:50994 ! has primary output primary amino compound creation_date: 2012-07-18T04:45:14Z [Term] id: GO:1901163 name: regulation of trophoblast cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061450 ! regulates trophoblast cell migration relationship: RO:0002211 GO:0061450 ! regulates trophoblast cell migration creation_date: 2012-07-19T07:53:06Z [Term] id: GO:1901164 name: negative regulation of trophoblast cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901163 ! regulation of trophoblast cell migration is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061450 ! negatively regulates trophoblast cell migration relationship: RO:0002212 GO:0061450 ! negatively regulates trophoblast cell migration creation_date: 2012-07-19T07:53:28Z [Term] id: GO:1901165 name: positive regulation of trophoblast cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901163 ! regulation of trophoblast cell migration is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061450 ! positively regulates trophoblast cell migration relationship: RO:0002213 GO:0061450 ! positively regulates trophoblast cell migration creation_date: 2012-07-19T07:53:35Z [Term] id: GO:1901166 name: neural crest cell migration involved in autonomic nervous system development namespace: biological_process def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie] is_a: GO:0001755 ! neural crest cell migration intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0048483 ! part of autonomic nervous system development relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development creation_date: 2012-07-19T08:39:56Z [Term] id: GO:1901190 name: regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex relationship: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex created_by: ss creation_date: 2012-07-25T02:26:58Z [Term] id: GO:1901191 name: negative regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031333 ! negative regulation of protein-containing complex assembly is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex relationship: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex creation_date: 2012-07-25T02:27:21Z [Term] id: GO:1901192 name: positive regulation of formation of translation initiation ternary complex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] is_a: GO:0031334 ! positive regulation of protein-containing complex assembly is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex relationship: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex creation_date: 2012-07-25T02:27:29Z [Term] id: GO:1901201 name: regulation of extracellular matrix assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly relationship: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly creation_date: 2012-07-27T04:04:00Z [Term] id: GO:1901202 name: negative regulation of extracellular matrix assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie] is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly relationship: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly creation_date: 2012-07-27T04:04:24Z [Term] id: GO:1901203 name: positive regulation of extracellular matrix assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie] synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1901201 ! regulation of extracellular matrix assembly is_a: GO:1903055 ! positive regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly relationship: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly creation_date: 2012-07-27T04:04:32Z [Term] id: GO:1901210 name: regulation of cardiac chamber formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003207 ! regulates cardiac chamber formation relationship: RO:0002211 GO:0003207 ! regulates cardiac chamber formation creation_date: 2012-07-31T07:18:35Z [Term] id: GO:1901211 name: negative regulation of cardiac chamber formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901210 ! regulation of cardiac chamber formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation relationship: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation creation_date: 2012-07-31T07:18:57Z [Term] id: GO:1901212 name: positive regulation of cardiac chamber formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie] synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie] is_a: GO:1901210 ! regulation of cardiac chamber formation is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation relationship: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation creation_date: 2012-07-31T07:19:05Z [Term] id: GO:1901219 name: regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:2000826 ! regulation of heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis relationship: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis creation_date: 2012-08-06T17:59:11Z [Term] id: GO:1901220 name: negative regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis relationship: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis creation_date: 2012-08-06T17:59:34Z [Term] id: GO:1901221 name: positive regulation of cardiac chamber morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis relationship: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis creation_date: 2012-08-06T17:59:42Z [Term] id: GO:1901264 name: carbohydrate derivative transport namespace: biological_process def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative creation_date: 2012-08-16T14:51:22Z [Term] id: GO:1901338 name: catecholamine binding namespace: molecular_function def: "Binding to catecholamine." [GOC:TermGenie] is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:33567 ! has primary input relationship: RO:0004009 CHEBI:33567 ! has primary input creation_date: 2012-09-03T14:08:44Z [Term] id: GO:1901342 name: regulation of vasculature development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001944 ! regulates vasculature development relationship: RO:0002211 GO:0001944 ! regulates vasculature development creation_date: 2012-09-06T09:16:15Z [Term] id: GO:1901343 name: negative regulation of vasculature development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie] synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie] synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie] synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001944 ! negatively regulates vasculature development relationship: RO:0002212 GO:0001944 ! negatively regulates vasculature development creation_date: 2012-09-06T09:17:24Z [Term] id: GO:1901363 name: heterocyclic compound binding namespace: molecular_function def: "Binding to heterocyclic compound." [GOC:TermGenie] is_a: GO:0036094 ! small molecule binding intersection_of: GO:0036094 ! small molecule binding intersection_of: RO:0004009 CHEBI:5686 ! has primary input heterocyclic compound relationship: RO:0004009 CHEBI:5686 ! has primary input heterocyclic compound creation_date: 2012-09-14T13:53:50Z [Term] id: GO:1901374 name: acetate ester transport namespace: biological_process def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:47622 ! has primary input relationship: RO:0004009 CHEBI:47622 ! has primary input creation_date: 2012-09-28T10:42:13Z [Term] id: GO:1901375 name: acetate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:47622 ! has primary input relationship: BFO:0000050 GO:1901374 ! part of acetate ester transport relationship: RO:0004009 CHEBI:47622 ! has primary input creation_date: 2012-09-28T10:47:08Z [Term] id: GO:1901503 name: ether biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie] synonym: "ether anabolism" EXACT [GOC:TermGenie] synonym: "ether biosynthesis" EXACT [GOC:TermGenie] synonym: "ether formation" EXACT [GOC:TermGenie] synonym: "ether synthesis" EXACT [GOC:TermGenie] is_a: GO:0009058 ! biosynthetic process created_by: pr creation_date: 2012-10-17T09:42:47Z [Term] id: GO:1901505 name: carbohydrate derivative transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] synonym: "carbohydrate derivative transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0022857 ! transmembrane transporter activity intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative relationship: BFO:0000050 GO:1901264 ! part of carbohydrate derivative transport relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative creation_date: 2012-10-17T10:31:22Z [Term] id: GO:1901509 name: regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie] is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis relationship: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis creation_date: 2012-10-17T14:30:40Z [Term] id: GO:1901532 name: regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation relationship: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation creation_date: 2012-10-24T11:23:01Z [Term] id: GO:1901533 name: negative regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation relationship: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation creation_date: 2012-10-24T11:23:06Z [Term] id: GO:1901534 name: positive regulation of hematopoietic progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT [] synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation relationship: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation creation_date: 2012-10-24T11:23:14Z [Term] id: GO:1901550 name: regulation of endothelial cell development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] is_a: GO:0045601 ! regulation of endothelial cell differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001885 ! regulates endothelial cell development relationship: RO:0002211 GO:0001885 ! regulates endothelial cell development creation_date: 2012-10-30T12:59:50Z [Term] id: GO:1901551 name: negative regulation of endothelial cell development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045602 ! negative regulation of endothelial cell differentiation is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development relationship: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development creation_date: 2012-10-30T12:59:54Z [Term] id: GO:1901552 name: positive regulation of endothelial cell development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1901550 ! regulation of endothelial cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001885 ! positively regulates endothelial cell development relationship: RO:0002213 GO:0001885 ! positively regulates endothelial cell development creation_date: 2012-10-30T12:59:58Z [Term] id: GO:1901588 name: dendritic microtubule namespace: cellular_component def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650] synonym: "microtubule of dendrite" EXACT [GOC:TermGenie] synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie] xref: NIF_Subcellular:sao110773650 is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0030425 ! part of dendrite relationship: BFO:0000050 GO:0030425 ! part of dendrite creation_date: 2012-11-07T14:37:30Z [Term] id: GO:1901589 name: axon microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678] synonym: "axon microtubule fascicle" EXACT [] synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie] xref: NIF_Subcellular:sao707332678 is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: BFO:0000050 GO:0030424 ! part of axon relationship: BFO:0000050 GO:0030424 ! part of axon creation_date: 2012-11-07T15:37:12Z [Term] id: GO:1901605 name: alpha-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006520 ! amino acid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino-acid zwitterion relationship: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino-acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:50Z [Term] id: GO:1901606 name: alpha-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009063 ! amino acid catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009056 ! catabolic process intersection_of: RO:0004009 CHEBI:78608 ! has primary input alpha-amino-acid zwitterion relationship: RO:0004009 CHEBI:78608 ! has primary input alpha-amino-acid zwitterion creation_date: 2012-11-08T17:39:54Z [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! amino acid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:78608 ! has primary output alpha-amino-acid zwitterion relationship: RO:0004008 CHEBI:78608 ! has primary output alpha-amino-acid zwitterion created_by: tb creation_date: 2012-11-08T17:39:58Z [Term] id: GO:1901608 name: regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule relationship: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule creation_date: 2012-11-08T21:49:44Z [Term] id: GO:1901609 name: negative regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule relationship: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule creation_date: 2012-11-08T21:49:48Z [Term] id: GO:1901610 name: positive regulation of vesicle transport along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1901608 ! regulation of vesicle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule relationship: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule creation_date: 2012-11-08T21:49:53Z [Term] id: GO:1901623 name: regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048247 ! regulates lymphocyte chemotaxis relationship: RO:0002211 GO:0048247 ! regulates lymphocyte chemotaxis creation_date: 2012-11-13T23:03:23Z [Term] id: GO:1901624 name: negative regulation of lymphocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000402 ! negative regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048247 ! negatively regulates lymphocyte chemotaxis relationship: RO:0002212 GO:0048247 ! negatively regulates lymphocyte chemotaxis creation_date: 2012-11-13T23:03:28Z [Term] id: GO:1901626 name: regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] synonym: "regulation of post-synaptic membrane organization" EXACT [] synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001941 ! regulates postsynaptic membrane organization relationship: RO:0002211 GO:0001941 ! regulates postsynaptic membrane organization creation_date: 2012-11-15T11:40:15Z [Term] id: GO:1901627 name: negative regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "negative regulation of post-synaptic membrane organization" EXACT [] synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] is_a: GO:1901626 ! regulation of postsynaptic membrane organization is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001941 ! negatively regulates postsynaptic membrane organization relationship: RO:0002212 GO:0001941 ! negatively regulates postsynaptic membrane organization creation_date: 2012-11-15T11:40:20Z [Term] id: GO:1901628 name: positive regulation of postsynaptic membrane organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie] synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie] synonym: "positive regulation of post-synaptic membrane organization" EXACT [] synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901626 ! regulation of postsynaptic membrane organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001941 ! positively regulates postsynaptic membrane organization relationship: RO:0002213 GO:0001941 ! positively regulates postsynaptic membrane organization creation_date: 2012-11-15T11:40:24Z [Term] id: GO:1901652 name: response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion creation_date: 2012-11-20T09:45:15Z [Term] id: GO:1901653 name: cellular response to peptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901652 ! response to peptide intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion creation_date: 2012-11-20T09:45:19Z [Term] id: GO:1901692 name: regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process relationship: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process creation_date: 2012-12-12T10:28:35Z [Term] id: GO:1901693 name: negative regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process relationship: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process creation_date: 2012-12-12T10:28:40Z [Term] id: GO:1901694 name: positive regulation of compound eye retinal cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] synonym: "induction of compound eye retinal cell programmed cell death" RELATED [] synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process relationship: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process creation_date: 2012-12-12T10:28:45Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901699 name: cellular response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cellular response to nitrogen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity creation_date: 2012-12-13T15:06:13Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity relationship: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901701 name: cellular response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to oxygen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity creation_date: 2012-12-13T15:11:42Z [Term] id: GO:1901706 name: mesenchymal cell differentiation involved in bone development namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0048762 ! mesenchymal cell differentiation intersection_of: BFO:0000050 GO:0060348 ! part of bone development relationship: BFO:0000050 GO:0060348 ! part of bone development creation_date: 2012-12-14T16:04:16Z [Term] id: GO:1901715 name: regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009450 ! regulates gamma-aminobutyric acid catabolic process relationship: RO:0002211 GO:0009450 ! regulates gamma-aminobutyric acid catabolic process creation_date: 2012-12-19T16:13:24Z [Term] id: GO:1901716 name: negative regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009450 ! negatively regulates gamma-aminobutyric acid catabolic process relationship: RO:0002212 GO:0009450 ! negatively regulates gamma-aminobutyric acid catabolic process creation_date: 2012-12-19T16:13:31Z [Term] id: GO:1901717 name: positive regulation of gamma-aminobutyric acid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009450 ! positively regulates gamma-aminobutyric acid catabolic process relationship: RO:0002213 GO:0009450 ! positively regulates gamma-aminobutyric acid catabolic process creation_date: 2012-12-19T16:13:36Z [Term] id: GO:1901858 name: regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032042 ! regulates mitochondrial DNA metabolic process relationship: RO:0002211 GO:0032042 ! regulates mitochondrial DNA metabolic process creation_date: 2013-02-01T10:05:04Z [Term] id: GO:1901859 name: negative regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032042 ! negatively regulates mitochondrial DNA metabolic process relationship: RO:0002212 GO:0032042 ! negatively regulates mitochondrial DNA metabolic process creation_date: 2013-02-01T10:05:09Z [Term] id: GO:1901860 name: positive regulation of mitochondrial DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032042 ! positively regulates mitochondrial DNA metabolic process relationship: RO:0002213 GO:0007005 ! positively regulates mitochondrion organization relationship: RO:0002213 GO:0032042 ! positively regulates mitochondrial DNA metabolic process creation_date: 2013-02-01T10:05:14Z [Term] id: GO:1901861 name: regulation of muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060537 ! regulates muscle tissue development relationship: RO:0002211 GO:0060537 ! regulates muscle tissue development creation_date: 2013-02-01T10:30:47Z [Term] id: GO:1901862 name: negative regulation of muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development relationship: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development creation_date: 2013-02-01T10:30:52Z [Term] id: GO:1901863 name: positive regulation of muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060537 ! positively regulates muscle tissue development relationship: RO:0002213 GO:0060537 ! positively regulates muscle tissue development creation_date: 2013-02-01T10:30:57Z [Term] id: GO:1901879 name: regulation of protein depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051261 ! regulates protein depolymerization relationship: RO:0002211 GO:0051261 ! regulates protein depolymerization creation_date: 2013-02-06T13:57:23Z [Term] id: GO:1901880 name: negative regulation of protein depolymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie] synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization relationship: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization creation_date: 2013-02-06T13:57:28Z [Term] id: GO:1901881 name: positive regulation of protein depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie] synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie] synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie] is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly is_a: GO:1901879 ! regulation of protein depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051261 ! positively regulates protein depolymerization relationship: RO:0002213 GO:0051261 ! positively regulates protein depolymerization creation_date: 2013-02-06T13:57:32Z [Term] id: GO:1901888 name: regulation of cell junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0034329 ! regulates cell junction assembly relationship: RO:0002211 GO:0034329 ! regulates cell junction assembly creation_date: 2013-02-06T19:40:32Z [Term] id: GO:1901889 name: negative regulation of cell junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly relationship: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly creation_date: 2013-02-06T19:40:41Z [Term] id: GO:1901890 name: positive regulation of cell junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie] synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0034329 ! positively regulates cell junction assembly relationship: RO:0002213 GO:0034329 ! positively regulates cell junction assembly creation_date: 2013-02-06T19:40:46Z [Term] id: GO:1901950 name: dense core granule transport namespace: biological_process def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451] comment: goslim_synapse synonym: "dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0016482 ! cytosolic transport is_a: GO:0032253 ! dense core granule localization is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule creation_date: 2013-02-19T13:00:52Z [Term] id: GO:1901951 name: regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990048 ! regulates anterograde neuronal dense core vesicle transport relationship: RO:0002211 GO:1990048 ! regulates anterograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:21Z [Term] id: GO:1901952 name: negative regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1901951 ! regulation of anterograde dense core granule transport is_a: GO:1904810 ! negative regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990048 ! negatively regulates anterograde neuronal dense core vesicle transport relationship: RO:0002212 GO:1990048 ! negatively regulates anterograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:30Z [Term] id: GO:1901953 name: positive regulation of anterograde dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie] synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1901951 ! regulation of anterograde dense core granule transport is_a: GO:1904811 ! positive regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990048 ! positively regulates anterograde neuronal dense core vesicle transport relationship: RO:0002213 GO:1990048 ! positively regulates anterograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:35Z [Term] id: GO:1901954 name: regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] is_a: GO:1901608 ! regulation of vesicle transport along microtubule is_a: GO:1904809 ! regulation of dense core granule transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990049 ! regulates retrograde neuronal dense core vesicle transport relationship: RO:0002211 GO:1990049 ! regulates retrograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:43Z [Term] id: GO:1901955 name: negative regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie] is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule is_a: GO:1901954 ! regulation of retrograde dense core granule transport is_a: GO:1904810 ! negative regulation of dense core granule transport is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990049 ! negatively regulates retrograde neuronal dense core vesicle transport relationship: RO:0002212 GO:1990049 ! negatively regulates retrograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:47Z [Term] id: GO:1901956 name: positive regulation of retrograde dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie] synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule is_a: GO:1901954 ! regulation of retrograde dense core granule transport is_a: GO:1904811 ! positive regulation of dense core granule transport is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990049 ! positively regulates retrograde neuronal dense core vesicle transport relationship: RO:0002213 GO:1990049 ! positively regulates retrograde neuronal dense core vesicle transport creation_date: 2013-02-19T13:36:52Z [Term] id: GO:1901963 name: regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis relationship: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis creation_date: 2013-02-20T20:30:26Z [Term] id: GO:1901964 name: positive regulation of cell proliferation involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis relationship: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis creation_date: 2013-02-20T20:30:31Z [Term] id: GO:1902017 name: regulation of cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060271 ! regulates cilium assembly relationship: RO:0002211 GO:0060271 ! regulates cilium assembly creation_date: 2013-03-26T18:10:51Z [Term] id: GO:1902018 name: negative regulation of cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902017 ! regulation of cilium assembly is_a: GO:1902116 ! negative regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060271 ! negatively regulates cilium assembly relationship: RO:0002212 GO:0060271 ! negatively regulates cilium assembly creation_date: 2013-03-26T18:10:56Z [Term] id: GO:1902019 name: regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "regulation of ciliary cell motility" RELATED [] synonym: "regulation of cilium cell motility" EXACT [] is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060285 ! regulates cilium-dependent cell motility relationship: RO:0002211 GO:0060285 ! regulates cilium-dependent cell motility creation_date: 2013-03-27T14:42:38Z [Term] id: GO:1902020 name: negative regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie] synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie] synonym: "negative regulation of ciliary cell motility" RELATED [] synonym: "negative regulation of cilium cell motility" EXACT [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000146 ! negative regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060285 ! negatively regulates cilium-dependent cell motility relationship: RO:0002212 GO:0060285 ! negatively regulates cilium-dependent cell motility creation_date: 2013-03-27T14:42:42Z [Term] id: GO:1902033 name: regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation relationship: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation creation_date: 2013-04-02T05:13:19Z [Term] id: GO:1902034 name: negative regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:1903707 ! negative regulation of hemopoiesis is_a: GO:2000647 ! negative regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation relationship: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation creation_date: 2013-04-02T05:13:24Z [Term] id: GO:1902035 name: positive regulation of hematopoietic stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation is_a: GO:2000648 ! positive regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation relationship: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation creation_date: 2013-04-02T05:13:31Z [Term] id: GO:1902036 name: regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] xref: Reactome:R-HSA-8939236 "RUNX1 regulates transcription of genes involved in differentiation of HSCs" is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation relationship: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation creation_date: 2013-04-02T05:19:09Z [Term] id: GO:1902037 name: negative regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation relationship: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation creation_date: 2013-04-02T05:19:14Z [Term] id: GO:1902038 name: positive regulation of hematopoietic stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation relationship: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation creation_date: 2013-04-02T05:19:19Z [Term] id: GO:1902065 name: response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009] is_a: GO:0043200 ! response to amino acid is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:29985 ! has primary input relationship: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2013-04-16T21:21:14Z [Term] id: GO:1902105 name: regulation of leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002521 ! regulates leukocyte differentiation relationship: RO:0002211 GO:0002521 ! regulates leukocyte differentiation creation_date: 2013-05-02T17:32:42Z [Term] id: GO:1902106 name: negative regulation of leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903707 ! negative regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation relationship: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation creation_date: 2013-05-02T17:32:47Z [Term] id: GO:1902107 name: positive regulation of leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie] is_a: GO:1902105 ! regulation of leukocyte differentiation is_a: GO:1903708 ! positive regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation relationship: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation creation_date: 2013-05-02T17:32:52Z [Term] id: GO:1902115 name: regulation of organelle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0044087 ! regulation of cellular component biogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070925 ! regulates organelle assembly relationship: RO:0002211 GO:0070925 ! regulates organelle assembly created_by: pr creation_date: 2013-05-14T09:43:21Z [Term] id: GO:1902116 name: negative regulation of organelle assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070925 ! negatively regulates organelle assembly relationship: RO:0002212 GO:0070925 ! negatively regulates organelle assembly creation_date: 2013-05-14T09:43:31Z [Term] id: GO:1902117 name: positive regulation of organelle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070925 ! positively regulates organelle assembly relationship: RO:0002213 GO:0070925 ! positively regulates organelle assembly creation_date: 2013-05-14T09:43:36Z [Term] id: GO:1902211 name: regulation of prolactin signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0038161 ! regulates prolactin signaling pathway relationship: RO:0002211 GO:0038161 ! regulates prolactin signaling pathway creation_date: 2013-06-12T10:10:07Z [Term] id: GO:1902212 name: negative regulation of prolactin signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie] synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:1902211 ! regulation of prolactin signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0038161 ! negatively regulates prolactin signaling pathway relationship: RO:0002212 GO:0038161 ! negatively regulates prolactin signaling pathway creation_date: 2013-06-12T10:10:12Z [Term] id: GO:1902213 name: positive regulation of prolactin signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie] synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway is_a: GO:1902211 ! regulation of prolactin signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0038161 ! positively regulates prolactin signaling pathway relationship: RO:0002213 GO:0038161 ! positively regulates prolactin signaling pathway creation_date: 2013-06-12T10:10:18Z [Term] id: GO:1902217 name: erythrocyte apoptotic process namespace: biological_process def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptosis" NARROW [GOC:TermGenie] synonym: "RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033028 ! myeloid cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000232 ! occurs in erythrocyte relationship: BFO:0000066 CL:0000232 ! occurs in erythrocyte creation_date: 2013-06-13T10:02:29Z [Term] id: GO:1902250 name: regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process relationship: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process creation_date: 2013-06-20T19:30:53Z [Term] id: GO:1902251 name: negative regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process relationship: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process creation_date: 2013-06-20T19:30:59Z [Term] id: GO:1902252 name: positive regulation of erythrocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:1902250 ! regulation of erythrocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process relationship: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process creation_date: 2013-06-20T19:31:04Z [Term] id: GO:1902256 name: regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis creation_date: 2013-06-24T19:12:24Z [Term] id: GO:1902257 name: negative regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis creation_date: 2013-06-24T19:12:30Z [Term] id: GO:1902258 name: positive regulation of apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis relationship: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis creation_date: 2013-06-24T19:12:42Z [Term] id: GO:1902262 name: apoptotic process involved in blood vessel morphogenesis namespace: biological_process def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358] synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis creation_date: 2013-06-25T16:16:00Z [Term] id: GO:1902275 name: regulation of chromatin organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] synonym: "regulation of chromatin assembly or disassembly" RELATED [] synonym: "regulation of chromatin assembly/disassembly" RELATED [] synonym: "regulation of chromatin modification" RELATED [] synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006325 ! regulates chromatin organization relationship: RO:0002211 GO:0006325 ! regulates chromatin organization creation_date: 2013-07-01T13:21:52Z [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis relationship: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis creation_date: 2013-07-29T15:03:16Z [Term] id: GO:1902338 name: negative regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904746 ! negative regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis relationship: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis creation_date: 2013-07-29T15:03:25Z [Term] id: GO:1902339 name: positive regulation of apoptotic process involved in morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis is_a: GO:1904747 ! positive regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis relationship: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis creation_date: 2013-07-29T15:03:33Z [Term] id: GO:1902340 name: negative regulation of chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725] synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation relationship: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation creation_date: 2013-07-29T20:54:14Z [Term] id: GO:1902369 name: negative regulation of RNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process relationship: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process creation_date: 2013-08-22T14:59:39Z [Term] id: GO:1902396 name: protein localization to bicellular tight junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie] synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie] synonym: "protein localization in tight junction" EXACT [GOC:TermGenie] is_a: GO:0150105 ! protein localization to cell-cell junction intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005923 ! has target end location bicellular tight junction relationship: RO:0002339 GO:0005923 ! has target end location bicellular tight junction creation_date: 2013-09-11T21:43:13Z [Term] id: GO:1902414 name: protein localization to cell junction namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111] synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie] synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie] synonym: "protein localization in cell junction" EXACT [GOC:TermGenie] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0030054 ! has target end location cell junction relationship: RO:0002339 GO:0030054 ! has target end location cell junction creation_date: 2013-09-13T16:55:57Z [Term] id: GO:1902463 name: protein localization to cell leading edge namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326] synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0031252 ! has target end location cell leading edge relationship: RO:0002339 GO:0031252 ! has target end location cell leading edge creation_date: 2013-10-22T12:36:07Z [Term] id: GO:1902473 name: regulation of protein localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035418 ! regulates protein localization to synapse relationship: RO:0002211 GO:0035418 ! regulates protein localization to synapse creation_date: 2013-10-25T15:09:09Z [Term] id: GO:1902474 name: positive regulation of protein localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse relationship: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse creation_date: 2013-10-25T15:09:18Z [Term] id: GO:1902475 name: L-alpha-amino acid transmembrane transport namespace: biological_process def: "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion creation_date: 2013-10-25T15:17:39Z [Term] id: GO:1902494 name: catalytic complex namespace: cellular_component def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] subset: goslim_metagenomics synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0003824 ! capable of catalytic activity relationship: RO:0002215 GO:0003824 ! capable of catalytic activity creation_date: 2013-11-13T16:18:47Z [Term] id: GO:1902495 name: transmembrane transporter complex namespace: cellular_component def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] is_a: GO:0098796 ! membrane protein complex is_a: GO:1990351 ! transporter complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0022857 ! capable of transmembrane transporter activity relationship: RO:0002215 GO:0022857 ! capable of transmembrane transporter activity creation_date: 2013-11-13T16:23:04Z [Term] id: GO:1902510 name: regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie] synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie] synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006309 ! regulates apoptotic DNA fragmentation relationship: RO:0002211 GO:0006309 ! regulates apoptotic DNA fragmentation creation_date: 2013-11-15T18:28:32Z [Term] id: GO:1902511 name: negative regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation is_a: GO:1903625 ! negative regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006309 ! negatively regulates apoptotic DNA fragmentation relationship: RO:0002212 GO:0006309 ! negatively regulates apoptotic DNA fragmentation creation_date: 2013-11-15T18:28:41Z [Term] id: GO:1902512 name: positive regulation of apoptotic DNA fragmentation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation is_a: GO:1903626 ! positive regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006309 ! positively regulates apoptotic DNA fragmentation relationship: RO:0002213 GO:0006309 ! positively regulates apoptotic DNA fragmentation creation_date: 2013-11-15T18:28:50Z [Term] id: GO:1902513 name: regulation of organelle transport along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087] synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule relationship: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule creation_date: 2013-11-15T20:15:17Z [Term] id: GO:1902531 name: regulation of intracellular signal transduction namespace: biological_process alt_id: GO:0010627 def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "regulation of intracellular protein kinase cascade" NARROW [] synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009966 ! regulation of signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035556 ! regulates intracellular signal transduction relationship: RO:0002211 GO:0035556 ! regulates intracellular signal transduction created_by: bf creation_date: 2013-12-02T11:32:52Z [Term] id: GO:1902532 name: negative regulation of intracellular signal transduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction relationship: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction creation_date: 2013-12-02T11:33:01Z [Term] id: GO:1902533 name: positive regulation of intracellular signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1902531 ! regulation of intracellular signal transduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction relationship: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction creation_date: 2013-12-02T11:33:10Z [Term] id: GO:1902570 name: protein localization to nucleolus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626] synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005730 ! has target end location nucleolus relationship: RO:0002339 GO:0005730 ! has target end location nucleolus creation_date: 2013-12-10T16:25:28Z [Term] id: GO:1902652 name: secondary alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie] is_a: GO:0006066 ! alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:14:52Z [Term] id: GO:1902653 name: secondary alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie] synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "secondary alcohol formation" EXACT [GOC:TermGenie] synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie] is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: tt creation_date: 2014-01-22T10:15:02Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process relationship: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process relationship: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902683 name: regulation of receptor localization to synapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097120 ! regulates receptor localization to synapse relationship: RO:0002211 GO:0097120 ! regulates receptor localization to synapse creation_date: 2014-02-07T17:38:31Z [Term] id: GO:1902684 name: negative regulation of receptor localization to synapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie] synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie] synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1902683 ! regulation of receptor localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097120 ! negatively regulates receptor localization to synapse relationship: RO:0002212 GO:0097120 ! negatively regulates receptor localization to synapse creation_date: 2014-02-07T17:38:41Z [Term] id: GO:1902685 name: positive regulation of receptor localization to synapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie] synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie] synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1902683 ! regulation of receptor localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097120 ! positively regulates receptor localization to synapse relationship: RO:0002213 GO:0097120 ! positively regulates receptor localization to synapse creation_date: 2014-02-07T17:38:51Z [Term] id: GO:1902692 name: regulation of neuroblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007405 ! regulates neuroblast proliferation relationship: RO:0002211 GO:0007405 ! regulates neuroblast proliferation creation_date: 2014-02-18T10:03:31Z [Term] id: GO:1902710 name: GABA receptor complex namespace: cellular_component def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] synonym: "gamma-aminobutyric acid receptor complex" EXACT [] is_a: GO:0043235 ! receptor complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0016917 ! capable of GABA receptor activity relationship: RO:0002215 GO:0016917 ! capable of GABA receptor activity creation_date: 2014-02-20T16:07:48Z [Term] id: GO:1902721 name: negative regulation of prolactin secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie] is_a: GO:0050709 ! negative regulation of protein secretion is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070459 ! negatively regulates prolactin secretion relationship: RO:0002212 GO:0070459 ! negatively regulates prolactin secretion creation_date: 2014-02-24T16:09:28Z [Term] id: GO:1902722 name: positive regulation of prolactin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie] synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070459 ! positively regulates prolactin secretion relationship: RO:0002213 GO:0070459 ! positively regulates prolactin secretion creation_date: 2014-02-24T16:09:37Z [Term] id: GO:1902738 name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:1903010 ! regulation of bone development is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis relationship: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis creation_date: 2014-02-26T15:36:15Z [Term] id: GO:1902742 name: apoptotic process involved in development namespace: biological_process def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic process involved in anatomical structure development" EXACT [] synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0048856 ! part of anatomical structure development relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development creation_date: 2014-02-28T13:09:43Z [Term] id: GO:1902761 name: positive regulation of chondrocyte development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie] synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie] synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0032332 ! positive regulation of chondrocyte differentiation is_a: GO:0061181 ! regulation of chondrocyte development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002063 ! positively regulates chondrocyte development relationship: RO:0002213 GO:0002063 ! positively regulates chondrocyte development creation_date: 2014-03-07T17:45:55Z [Term] id: GO:1902809 name: regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation relationship: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation creation_date: 2014-03-26T21:18:26Z [Term] id: GO:1902810 name: negative regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] is_a: GO:0010832 ! negative regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation relationship: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation creation_date: 2014-03-26T21:18:32Z [Term] id: GO:1902811 name: positive regulation of skeletal muscle fiber differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] is_a: GO:0010831 ! positive regulation of myotube differentiation is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation relationship: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation creation_date: 2014-03-26T21:18:38Z [Term] id: GO:1902816 name: regulation of protein localization to microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035372 ! regulates protein localization to microtubule relationship: RO:0002211 GO:0035372 ! regulates protein localization to microtubule creation_date: 2014-03-27T22:07:12Z [Term] id: GO:1902817 name: negative regulation of protein localization to microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:1902816 ! regulation of protein localization to microtubule is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule relationship: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule creation_date: 2014-03-27T22:07:18Z [Term] id: GO:1902838 name: regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie] synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie] synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:1902513 ! regulation of organelle transport along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule relationship: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule creation_date: 2014-04-01T13:50:23Z [Term] id: GO:1902839 name: negative regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule relationship: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule creation_date: 2014-04-01T13:50:29Z [Term] id: GO:1902840 name: positive regulation of nuclear migration along microtubule namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie] synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie] synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1902838 ! regulation of nuclear migration along microtubule intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule relationship: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule creation_date: 2014-04-01T13:50:35Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902863 name: regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development relationship: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development creation_date: 2014-04-03T15:24:00Z [Term] id: GO:1902864 name: negative regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie] synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development relationship: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development creation_date: 2014-04-03T15:24:06Z [Term] id: GO:1902865 name: positive regulation of embryonic camera-type eye development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie] synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie] synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1902863 ! regulation of embryonic camera-type eye development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development relationship: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development creation_date: 2014-04-03T15:24:12Z [Term] id: GO:1902866 name: regulation of retina development in camera-type eye namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye relationship: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye creation_date: 2014-04-03T15:24:17Z [Term] id: GO:1902867 name: negative regulation of retina development in camera-type eye namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down regulation of retinal development" RELATED [GOC:TermGenie] synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "downregulation of retinal development" RELATED [GOC:TermGenie] synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "inhibition of retinal development" RELATED [GOC:TermGenie] synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye relationship: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye creation_date: 2014-04-03T15:24:23Z [Term] id: GO:1902868 name: positive regulation of retina development in camera-type eye namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie] synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie] synonym: "activation of retinal development" RELATED [GOC:TermGenie] synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up regulation of retinal development" RELATED [GOC:TermGenie] synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie] synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] synonym: "upregulation of retinal development" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902866 ! regulation of retina development in camera-type eye intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye relationship: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye creation_date: 2014-04-03T15:24:29Z [Term] id: GO:1902875 name: regulation of embryonic pattern specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie] synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie] synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009880 ! regulates embryonic pattern specification relationship: RO:0002211 GO:0009880 ! regulates embryonic pattern specification creation_date: 2014-04-03T15:25:15Z [Term] id: GO:1902876 name: negative regulation of embryonic pattern specification namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie] synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1902875 ! regulation of embryonic pattern specification intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009880 ! negatively regulates embryonic pattern specification relationship: RO:0002212 GO:0009880 ! negatively regulates embryonic pattern specification creation_date: 2014-04-03T15:25:20Z [Term] id: GO:1902877 name: positive regulation of embryonic pattern specification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie] synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie] synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie] synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1902875 ! regulation of embryonic pattern specification intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009880 ! positively regulates embryonic pattern specification relationship: RO:0002213 GO:0009880 ! positively regulates embryonic pattern specification creation_date: 2014-04-03T15:25:26Z [Term] id: GO:1902882 name: regulation of response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006979 ! regulates response to oxidative stress relationship: RO:0002211 GO:0006979 ! regulates response to oxidative stress creation_date: 2014-04-03T20:29:52Z [Term] id: GO:1902883 name: negative regulation of response to oxidative stress namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006979 ! negatively regulates response to oxidative stress relationship: RO:0002212 GO:0006979 ! negatively regulates response to oxidative stress creation_date: 2014-04-03T20:30:20Z [Term] id: GO:1902884 name: positive regulation of response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie] synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie] synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1902882 ! regulation of response to oxidative stress intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006979 ! positively regulates response to oxidative stress relationship: RO:0002213 GO:0006979 ! positively regulates response to oxidative stress creation_date: 2014-04-03T20:30:47Z [Term] id: GO:1902903 name: regulation of supramolecular fiber organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization relationship: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization creation_date: 2014-04-15T16:46:36Z [Term] id: GO:1902904 name: negative regulation of supramolecular fiber organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie] synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie] synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization relationship: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization creation_date: 2014-04-15T16:46:42Z [Term] id: GO:1902905 name: positive regulation of supramolecular fiber organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro synonym: "activation of fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of fibril organization" NARROW [GOC:TermGenie] synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie] synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization relationship: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization creation_date: 2014-04-15T16:46:48Z [Term] id: GO:1902913 name: positive regulation of neuroepithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506] synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation relationship: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation creation_date: 2014-04-18T21:06:42Z [Term] id: GO:1902930 name: regulation of alcohol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie] synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie] synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie] synonym: "regulation of solventogenesis" BROAD [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0046165 ! regulates alcohol biosynthetic process relationship: RO:0002211 GO:0046165 ! regulates alcohol biosynthetic process created_by: tt creation_date: 2014-04-22T21:55:03Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0006996 ! organelle organization is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0043226 ! results in disassembly of organelle relationship: RO:0002590 GO:0043226 ! results in disassembly of organelle created_by: jl creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903010 name: regulation of bone development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060348 ! regulates bone development relationship: RO:0002211 GO:0060348 ! regulates bone development creation_date: 2014-05-13T22:41:53Z [Term] id: GO:1903011 name: negative regulation of bone development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "down regulation of bone development" EXACT [GOC:TermGenie] synonym: "down-regulation of bone development" EXACT [GOC:TermGenie] synonym: "downregulation of bone development" EXACT [GOC:TermGenie] synonym: "inhibition of bone development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060348 ! negatively regulates bone development relationship: RO:0002212 GO:0060348 ! negatively regulates bone development creation_date: 2014-05-13T22:42:00Z [Term] id: GO:1903012 name: positive regulation of bone development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] synonym: "activation of bone development" NARROW [GOC:TermGenie] synonym: "up regulation of bone development" EXACT [GOC:TermGenie] synonym: "up-regulation of bone development" EXACT [GOC:TermGenie] synonym: "upregulation of bone development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903010 ! regulation of bone development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060348 ! positively regulates bone development relationship: RO:0002213 GO:0060348 ! positively regulates bone development creation_date: 2014-05-13T22:42:06Z [Term] id: GO:1903018 name: regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process relationship: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process creation_date: 2014-05-14T18:44:19Z [Term] id: GO:1903019 name: negative regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051248 ! negative regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process relationship: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process creation_date: 2014-05-14T18:44:25Z [Term] id: GO:1903020 name: positive regulation of glycoprotein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie] synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie] synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] is_a: GO:0051247 ! positive regulation of protein metabolic process is_a: GO:1903018 ! regulation of glycoprotein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process relationship: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process creation_date: 2014-05-14T18:44:31Z [Term] id: GO:1903037 name: regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022407 ! regulation of cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007159 ! regulates leukocyte cell-cell adhesion relationship: RO:0002211 GO:0007159 ! regulates leukocyte cell-cell adhesion creation_date: 2014-05-19T15:29:58Z [Term] id: GO:1903038 name: negative regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie] synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022408 ! negative regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007159 ! negatively regulates leukocyte cell-cell adhesion relationship: RO:0002212 GO:0007159 ! negatively regulates leukocyte cell-cell adhesion creation_date: 2014-05-19T15:30:05Z [Term] id: GO:1903039 name: positive regulation of leukocyte cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie] synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie] synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007159 ! positively regulates leukocyte cell-cell adhesion relationship: RO:0002213 GO:0007159 ! positively regulates leukocyte cell-cell adhesion creation_date: 2014-05-19T15:30:15Z [Term] id: GO:1903045 name: neural crest cell migration involved in sympathetic nervous system development namespace: biological_process def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129] comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development intersection_of: GO:0001755 ! neural crest cell migration intersection_of: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development relationship: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development creation_date: 2014-05-22T07:06:02Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate subset: goslim_pombe is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: BFO:0000050 GO:0051321 ! part of meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] subset: gocheck_do_not_annotate is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle relationship: BFO:0000050 GO:0000278 ! part of mitotic cell cycle creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903053 name: regulation of extracellular matrix organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030198 ! regulates extracellular matrix organization relationship: RO:0002211 GO:0030198 ! regulates extracellular matrix organization creation_date: 2014-05-23T17:15:41Z [Term] id: GO:1903054 name: negative regulation of extracellular matrix organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization relationship: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization creation_date: 2014-05-23T17:15:47Z [Term] id: GO:1903055 name: positive regulation of extracellular matrix organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie] synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization relationship: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization creation_date: 2014-05-23T17:15:53Z [Term] id: GO:1903076 name: regulation of protein localization to plasma membrane namespace: biological_process alt_id: GO:0090003 alt_id: GO:1905963 def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein targeting to plasma membrane" RELATED [] synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane relationship: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane created_by: tb creation_date: 2009-07-10T10:32:44Z [Term] id: GO:1903077 name: negative regulation of protein localization to plasma membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED [] synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein targeting to plasma membrane" RELATED [] synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane relationship: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane creation_date: 2014-05-29T17:10:16Z [Term] id: GO:1903078 name: positive regulation of protein localization to plasma membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie] synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED [] synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein targeting to plasma membrane" RELATED [] synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] is_a: GO:1903076 ! regulation of protein localization to plasma membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane relationship: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane creation_date: 2009-07-10T10:34:17Z [Term] id: GO:1903115 name: regulation of actin filament-based movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] is_a: GO:0032970 ! regulation of actin filament-based process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030048 ! regulates actin filament-based movement relationship: RO:0002211 GO:0030048 ! regulates actin filament-based movement creation_date: 2014-06-12T16:55:57Z [Term] id: GO:1903116 name: positive regulation of actin filament-based movement namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement relationship: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement creation_date: 2014-06-12T16:56:04Z [Term] id: GO:1903119 name: protein localization to actin cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton relationship: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton creation_date: 2014-06-16T11:27:09Z [Term] id: GO:1903120 name: protein localization to actin filament bundle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization to actin cable" RELATED [GOC:mah] is_a: GO:1903119 ! protein localization to actin cytoskeleton intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0032432 ! has target end location actin filament bundle relationship: RO:0002339 GO:0032432 ! has target end location actin filament bundle creation_date: 2014-06-16T11:27:16Z [Term] id: GO:1903131 name: mononuclear cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] is_a: GO:0002521 ! leukocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000842 ! results in acquisition of features of mononuclear leukocyte relationship: RO:0002315 CL:0000842 ! results in acquisition of features of mononuclear leukocyte creation_date: 2014-06-25T15:47:09Z [Term] id: GO:1903224 name: regulation of endodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation relationship: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation creation_date: 2014-07-29T13:22:35Z [Term] id: GO:1903225 name: negative regulation of endodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation relationship: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation creation_date: 2014-07-29T13:22:41Z [Term] id: GO:1903226 name: positive regulation of endodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1903224 ! regulation of endodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation relationship: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation creation_date: 2014-07-29T13:22:47Z [Term] id: GO:1903292 name: protein localization to Golgi membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902] synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie] is_a: GO:0034067 ! protein localization to Golgi apparatus is_a: GO:0072657 ! protein localization to membrane intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000139 ! has target end location Golgi membrane relationship: RO:0002339 GO:0000139 ! has target end location Golgi membrane creation_date: 2014-08-12T14:22:31Z [Term] id: GO:1903294 name: regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061535 ! regulates glutamate secretion, neurotransmission relationship: RO:0002211 GO:0061535 ! regulates glutamate secretion, neurotransmission creation_date: 2014-08-13T13:54:15Z [Term] id: GO:1903295 name: negative regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0014050 ! negative regulation of glutamate secretion is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061535 ! negatively regulates glutamate secretion, neurotransmission relationship: RO:0002212 GO:0061535 ! negatively regulates glutamate secretion, neurotransmission creation_date: 2014-08-13T13:54:23Z [Term] id: GO:1903296 name: positive regulation of glutamate secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014049 ! positive regulation of glutamate secretion is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061535 ! positively regulates glutamate secretion, neurotransmission relationship: RO:0002213 GO:0061535 ! positively regulates glutamate secretion, neurotransmission creation_date: 2014-08-13T13:54:31Z [Term] id: GO:1903335 name: regulation of vacuolar transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007034 ! regulates vacuolar transport relationship: RO:0002211 GO:0007034 ! regulates vacuolar transport created_by: vw creation_date: 2014-08-18T13:16:04Z [Term] id: GO:1903336 name: negative regulation of vacuolar transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport relationship: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport creation_date: 2014-08-18T13:16:11Z [Term] id: GO:1903337 name: positive regulation of vacuolar transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie] synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1903335 ! regulation of vacuolar transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007034 ! positively regulates vacuolar transport relationship: RO:0002213 GO:0007034 ! positively regulates vacuolar transport creation_date: 2014-08-18T13:16:19Z [Term] id: GO:1903338 name: regulation of cell wall organization or biogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] synonym: "regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071554 ! regulates cell wall organization or biogenesis relationship: RO:0002211 GO:0071554 ! regulates cell wall organization or biogenesis created_by: vw creation_date: 2014-08-18T13:20:50Z [Term] id: GO:1903347 name: negative regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie] synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie] synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie] is_a: GO:1901889 ! negative regulation of cell junction assembly is_a: GO:2000810 ! regulation of bicellular tight junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070830 ! negatively regulates bicellular tight junction assembly relationship: RO:0002212 GO:0070830 ! negatively regulates bicellular tight junction assembly creation_date: 2014-08-19T11:02:14Z [Term] id: GO:1903348 name: positive regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie] synonym: "activation of tight junction formation" NARROW [GOC:TermGenie] synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie] is_a: GO:1901890 ! positive regulation of cell junction assembly is_a: GO:2000810 ! regulation of bicellular tight junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070830 ! positively regulates bicellular tight junction assembly relationship: RO:0002213 GO:0070830 ! positively regulates bicellular tight junction assembly creation_date: 2014-08-19T11:05:06Z [Term] id: GO:1903353 name: regulation of nucleus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006997 ! regulates nucleus organization relationship: RO:0002211 GO:0006997 ! regulates nucleus organization created_by: hjd creation_date: 2014-08-20T19:36:16Z [Term] id: GO:1903358 name: regulation of Golgi organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788] synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie] synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007030 ! regulates Golgi organization relationship: RO:0002211 GO:0007030 ! regulates Golgi organization creation_date: 2014-08-21T10:22:22Z [Term] id: GO:1903379 name: regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0060623 ! regulation of chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation relationship: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation creation_date: 2014-08-26T13:57:13Z [Term] id: GO:1903380 name: positive regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903379 ! regulation of mitotic chromosome condensation is_a: GO:1905821 ! positive regulation of chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation relationship: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation creation_date: 2014-08-26T13:57:29Z [Term] id: GO:1903409 name: reactive oxygen species biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "reactive oxygen species generation" RELATED [PMID:24252804] synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "ROS formation" RELATED [] synonym: "ROS generation" RELATED [PMID:24252804] is_a: GO:0009058 ! biosynthetic process is_a: GO:0072593 ! reactive oxygen species metabolic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:26523 ! has primary output reactive oxygen species relationship: RO:0004008 CHEBI:26523 ! has primary output reactive oxygen species created_by: bf creation_date: 2014-09-03T09:19:13Z [Term] id: GO:1903426 name: regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "regulation of ROS generation" RELATED [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903409 ! regulates reactive oxygen species biosynthetic process relationship: RO:0002211 GO:1903409 ! regulates reactive oxygen species biosynthetic process created_by: bf creation_date: 2014-09-11T10:01:47Z [Term] id: GO:1903427 name: negative regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie] synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie] synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie] synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie] synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie] synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "prevention of ROS generation" EXACT [PMID:24252804] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903409 ! negatively regulates reactive oxygen species biosynthetic process relationship: RO:0002212 GO:1903409 ! negatively regulates reactive oxygen species biosynthetic process creation_date: 2014-09-11T10:01:56Z [Term] id: GO:1903428 name: positive regulation of reactive oxygen species biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie] synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie] synonym: "activation of ROS formation" RELATED [GOC:TermGenie] synonym: "activation of ROS generation" RELATED [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie] synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie] synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie] synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903409 ! positively regulates reactive oxygen species biosynthetic process relationship: RO:0002213 GO:1903409 ! positively regulates reactive oxygen species biosynthetic process creation_date: 2014-09-11T10:02:05Z [Term] id: GO:1903429 name: regulation of cell maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048469 ! regulates cell maturation relationship: RO:0002211 GO:0048469 ! regulates cell maturation creation_date: 2014-09-15T13:31:23Z [Term] id: GO:1903430 name: negative regulation of cell maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie] synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie] synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048469 ! negatively regulates cell maturation relationship: RO:0002212 GO:0048469 ! negatively regulates cell maturation creation_date: 2014-09-15T13:31:32Z [Term] id: GO:1903431 name: positive regulation of cell maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] synonym: "activation of cell maturation" NARROW [GOC:TermGenie] synonym: "activation of functional differentiation" RELATED [GOC:TermGenie] synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie] synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie] synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:1903429 ! regulation of cell maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048469 ! positively regulates cell maturation relationship: RO:0002213 GO:0048469 ! positively regulates cell maturation creation_date: 2014-09-15T13:31:41Z [Term] id: GO:1903441 name: protein localization to ciliary membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0060170 ! has target end location ciliary membrane relationship: RO:0002339 GO:0060170 ! has target end location ciliary membrane creation_date: 2014-09-16T15:15:39Z [Term] id: GO:1903522 name: regulation of blood circulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008015 ! regulates blood circulation relationship: RO:0002211 GO:0008015 ! regulates blood circulation creation_date: 2014-10-06T18:38:56Z [Term] id: GO:1903523 name: negative regulation of blood circulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie] synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008015 ! negatively regulates blood circulation relationship: RO:0002212 GO:0008015 ! negatively regulates blood circulation creation_date: 2014-10-06T18:39:05Z [Term] id: GO:1903524 name: positive regulation of blood circulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] synonym: "activation of blood circulation" NARROW [GOC:TermGenie] synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie] synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie] synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie] synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903522 ! regulation of blood circulation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008015 ! positively regulates blood circulation relationship: RO:0002213 GO:0008015 ! positively regulates blood circulation creation_date: 2014-10-06T18:39:13Z [Term] id: GO:1903530 name: regulation of secretion by cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051046 ! regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032940 ! regulates secretion by cell relationship: RO:0002211 GO:0032940 ! regulates secretion by cell created_by: pm creation_date: 2014-10-08T13:24:59Z [Term] id: GO:1903531 name: negative regulation of secretion by cell namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032940 ! negatively regulates secretion by cell relationship: RO:0002212 GO:0032940 ! negatively regulates secretion by cell creation_date: 2014-10-08T13:25:08Z [Term] id: GO:1903532 name: positive regulation of secretion by cell namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032940 ! positively regulates secretion by cell relationship: RO:0002213 GO:0032940 ! positively regulates secretion by cell creation_date: 2014-10-08T13:25:17Z [Term] id: GO:1903537 name: meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "meiosis involved in oocyte maturation" BROAD [] is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1903046 ! meiotic cell cycle process intersection_of: BFO:0000050 GO:0001556 ! part of oocyte maturation relationship: BFO:0000050 GO:0001556 ! part of oocyte maturation creation_date: 2014-10-09T10:46:14Z [Term] id: GO:1903538 name: regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395] synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation creation_date: 2014-10-09T10:52:38Z [Term] id: GO:1903539 name: protein localization to postsynaptic membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322] synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0062237 ! protein localization to postsynapse is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane relationship: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane creation_date: 2014-10-10T11:23:53Z [Term] id: GO:1903540 name: establishment of protein localization to postsynaptic membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322] synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:1903539 ! protein localization to postsynaptic membrane intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane creation_date: 2014-10-10T11:24:03Z [Term] id: GO:1903541 name: regulation of exosomal secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0017157 ! regulation of exocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990182 ! regulates exosomal secretion relationship: RO:0002211 GO:1990182 ! regulates exosomal secretion creation_date: 2014-10-14T11:38:52Z [Term] id: GO:1903542 name: negative regulation of exosomal secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie] synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion relationship: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion creation_date: 2014-10-14T11:39:02Z [Term] id: GO:1903543 name: positive regulation of exosomal secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie] synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie] synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie] synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie] synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie] is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:1903541 ! regulation of exosomal secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990182 ! positively regulates exosomal secretion relationship: RO:0002213 GO:1990182 ! positively regulates exosomal secretion creation_date: 2014-10-14T11:39:10Z [Term] id: GO:1903551 name: regulation of extracellular exosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly relationship: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly creation_date: 2014-10-20T15:37:25Z [Term] id: GO:1903552 name: negative regulation of extracellular exosome assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly relationship: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly creation_date: 2014-10-20T15:37:33Z [Term] id: GO:1903553 name: positive regulation of extracellular exosome assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles] synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1903551 ! regulation of extracellular exosome assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly relationship: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly creation_date: 2014-10-20T15:37:42Z [Term] id: GO:1903561 name: extracellular vesicle namespace: cellular_component def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] synonym: "microparticle" RELATED [GOC:vesicles] is_a: GO:0031982 ! vesicle is_a: GO:0065010 ! extracellular membrane-bounded organelle intersection_of: GO:0031982 ! vesicle intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region creation_date: 2014-10-22T14:26:11Z [Term] id: GO:1903564 name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061512 ! regulates protein localization to cilium relationship: RO:0002211 GO:0061512 ! regulates protein localization to cilium creation_date: 2014-10-24T20:58:11Z [Term] id: GO:1903565 name: negative regulation of protein localization to cilium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium relationship: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium creation_date: 2014-10-24T20:58:20Z [Term] id: GO:1903566 name: positive regulation of protein localization to cilium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium relationship: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium creation_date: 2014-10-24T20:58:28Z [Term] id: GO:1903567 name: regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1904375 ! regulation of protein localization to cell periphery is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane relationship: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane creation_date: 2014-10-24T21:32:51Z [Term] id: GO:1903568 name: negative regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903565 ! negative regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1905476 ! negative regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane relationship: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane creation_date: 2014-10-24T21:32:59Z [Term] id: GO:1903569 name: positive regulation of protein localization to ciliary membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] is_a: GO:1903566 ! positive regulation of protein localization to cilium is_a: GO:1903567 ! regulation of protein localization to ciliary membrane is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1905477 ! positive regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane relationship: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane creation_date: 2014-10-24T21:33:08Z [Term] id: GO:1903624 name: regulation of DNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006308 ! regulates DNA catabolic process relationship: RO:0002211 GO:0006308 ! regulates DNA catabolic process creation_date: 2014-11-19T22:36:35Z [Term] id: GO:1903625 name: negative regulation of DNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006308 ! negatively regulates DNA catabolic process relationship: RO:0002212 GO:0006308 ! negatively regulates DNA catabolic process creation_date: 2014-11-19T22:36:43Z [Term] id: GO:1903626 name: positive regulation of DNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie] synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie] synonym: "activation of DNA degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie] synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:1903624 ! regulation of DNA catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006308 ! positively regulates DNA catabolic process relationship: RO:0002213 GO:0006308 ! positively regulates DNA catabolic process creation_date: 2014-11-19T22:36:51Z [Term] id: GO:1903664 name: regulation of asexual reproduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019954 ! regulates asexual reproduction relationship: RO:0002211 GO:0019954 ! regulates asexual reproduction created_by: pf creation_date: 2014-11-26T21:13:24Z [Term] id: GO:1903697 name: negative regulation of microvillus assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie] synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly relationship: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly creation_date: 2014-12-03T11:45:08Z [Term] id: GO:1903698 name: positive regulation of microvillus assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie] synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie] synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie] is_a: GO:0032534 ! regulation of microvillus assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030033 ! positively regulates microvillus assembly relationship: RO:0002213 GO:0030033 ! positively regulates microvillus assembly creation_date: 2014-12-03T11:45:17Z [Term] id: GO:1903701 name: substantia propria of cornea development namespace: biological_process def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382] synonym: "corneal stroma development" EXACT [GOC:TermGenie] synonym: "stroma of cornea development" EXACT [GOC:TermGenie] synonym: "substantia propria development" RELATED [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea relationship: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea creation_date: 2014-12-03T13:12:09Z [Term] id: GO:1903702 name: esophagus development namespace: biological_process def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] synonym: "esophageal development" EXACT [MGI:csmith] synonym: "gullet development" EXACT [GOC:TermGenie] synonym: "oesophagus development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001043 ! results in development of esophagus relationship: RO:0002296 UBERON:0001043 ! results in development of esophagus creation_date: 2014-12-03T14:41:30Z [Term] id: GO:1903706 name: regulation of hemopoiesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030097 ! regulates hemopoiesis relationship: RO:0002211 GO:0030097 ! regulates hemopoiesis creation_date: 2014-12-04T15:34:13Z [Term] id: GO:1903707 name: negative regulation of hemopoiesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie] synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie] synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie] synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis relationship: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis creation_date: 2014-12-04T15:34:21Z [Term] id: GO:1903708 name: positive regulation of hemopoiesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of blood cell formation" NARROW [GOC:TermGenie] synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie] synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie] synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie] synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie] synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030097 ! positively regulates hemopoiesis relationship: RO:0002213 GO:0030097 ! positively regulates hemopoiesis creation_date: 2014-12-04T15:34:30Z [Term] id: GO:1903729 name: regulation of plasma membrane organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie] synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007009 ! regulates plasma membrane organization relationship: RO:0002211 GO:0007009 ! regulates plasma membrane organization created_by: al creation_date: 2014-12-10T18:59:44Z [Term] id: GO:1903747 name: regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072655 ! regulates establishment of protein localization to mitochondrion relationship: RO:0002211 GO:0072655 ! regulates establishment of protein localization to mitochondrion creation_date: 2014-12-12T22:18:09Z [Term] id: GO:1903748 name: negative regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1904950 ! negative regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072655 ! negatively regulates establishment of protein localization to mitochondrion relationship: RO:0002212 GO:0072655 ! negatively regulates establishment of protein localization to mitochondrion creation_date: 2014-12-12T22:18:18Z [Term] id: GO:1903749 name: positive regulation of establishment of protein localization to mitochondrion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] xref: Reactome:R-HSA-114452 "Activation of BH3-only proteins" xref: Reactome:R-HSA-75108 "Activation, myristolyation of BID and translocation to mitochondria" is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion is_a: GO:1904951 ! positive regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072655 ! positively regulates establishment of protein localization to mitochondrion relationship: RO:0002213 GO:0072655 ! positively regulates establishment of protein localization to mitochondrion creation_date: 2014-12-12T22:18:26Z [Term] id: GO:1903778 name: protein localization to vacuolar membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562] synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0072665 ! protein localization to vacuole intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005774 ! has target end location vacuolar membrane relationship: RO:0002339 GO:0005774 ! has target end location vacuolar membrane creation_date: 2015-01-07T13:15:54Z [Term] id: GO:1903779 name: regulation of cardiac conduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] xref: Reactome:R-HSA-5578768 "Physiological factors" xref: Reactome:R-HSA-5578775 "Ion homeostasis" is_a: GO:0008016 ! regulation of heart contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061337 ! regulates cardiac conduction relationship: RO:0002211 GO:0061337 ! regulates cardiac conduction creation_date: 2015-01-07T13:20:11Z [Term] id: GO:1903780 name: negative regulation of cardiac conduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction relationship: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction creation_date: 2015-01-07T13:20:20Z [Term] id: GO:1903781 name: positive regulation of cardiac conduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1903779 ! regulation of cardiac conduction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061337 ! positively regulates cardiac conduction relationship: RO:0002213 GO:0061337 ! positively regulates cardiac conduction creation_date: 2015-01-07T13:20:28Z [Term] id: GO:1903789 name: regulation of amino acid transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814] synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport relationship: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport creation_date: 2015-01-08T17:42:18Z [Term] id: GO:1903804 name: glycine import across plasma membrane namespace: biological_process def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "glycine import" BROAD [] synonym: "glycine import into cell" EXACT [] is_a: GO:0015816 ! glycine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0006810 ! transport intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2012-05-11T01:16:45Z [Term] id: GO:1903825 name: organic acid transmembrane transport namespace: biological_process def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] is_a: GO:0015849 ! organic acid transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid creation_date: 2015-01-20T10:20:58Z [Term] id: GO:1903828 name: negative regulation of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein localization" EXACT [] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008104 ! negatively regulates intracellular protein localization relationship: RO:0002212 GO:0008104 ! negatively regulates intracellular protein localization creation_date: 2015-01-20T14:32:24Z [Term] id: GO:1903829 name: positive regulation of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein localization" EXACT [] synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008104 ! positively regulates intracellular protein localization relationship: RO:0002213 GO:0008104 ! positively regulates intracellular protein localization creation_date: 2015-01-20T14:32:33Z [Term] id: GO:1903847 name: regulation of aorta morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035909 ! regulates aorta morphogenesis relationship: RO:0002211 GO:0035909 ! regulates aorta morphogenesis creation_date: 2015-01-23T14:00:51Z [Term] id: GO:1903848 name: negative regulation of aorta morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905652 ! negative regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis relationship: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis creation_date: 2015-01-23T14:01:01Z [Term] id: GO:1903849 name: positive regulation of aorta morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie] is_a: GO:1903847 ! regulation of aorta morphogenesis is_a: GO:1905653 ! positive regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis relationship: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis creation_date: 2015-01-23T14:01:09Z [Term] id: GO:1903867 name: extraembryonic membrane development namespace: biological_process def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane creation_date: 2015-02-05T00:42:16Z [Term] id: GO:1903903 name: regulation of establishment of T cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:2000114 ! regulation of establishment of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001768 ! regulates establishment of T cell polarity relationship: RO:0002211 GO:0001768 ! regulates establishment of T cell polarity creation_date: 2015-02-09T10:50:21Z [Term] id: GO:1903904 name: negative regulation of establishment of T cell polarity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie] synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie] synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050868 ! negative regulation of T cell activation is_a: GO:1903903 ! regulation of establishment of T cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001768 ! negatively regulates establishment of T cell polarity relationship: RO:0002212 GO:0001768 ! negatively regulates establishment of T cell polarity creation_date: 2015-02-09T10:50:30Z [Term] id: GO:1903905 name: positive regulation of establishment of T cell polarity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie] synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] synonym: "activation of T cell polarization" NARROW [GOC:TermGenie] synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie] synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie] synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie] is_a: GO:0050870 ! positive regulation of T cell activation is_a: GO:1903903 ! regulation of establishment of T cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001768 ! positively regulates establishment of T cell polarity relationship: RO:0002213 GO:0001768 ! positively regulates establishment of T cell polarity creation_date: 2015-02-09T10:50:40Z [Term] id: GO:1903941 name: negative regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system relationship: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system creation_date: 2015-02-17T20:26:24Z [Term] id: GO:1903942 name: positive regulation of respiratory gaseous exchange namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie] synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] is_a: GO:0043576 ! regulation of respiratory gaseous exchange is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system relationship: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system creation_date: 2015-02-17T20:26:35Z [Term] id: GO:1903950 name: negative regulation of AV node cell action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential relationship: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential creation_date: 2015-02-20T14:59:41Z [Term] id: GO:1903951 name: positive regulation of AV node cell action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0098904 ! regulation of AV node cell action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential relationship: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential creation_date: 2015-02-20T14:59:50Z [Term] id: GO:1903975 name: regulation of glial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008347 ! regulates glial cell migration relationship: RO:0002211 GO:0008347 ! regulates glial cell migration creation_date: 2015-03-02T15:13:31Z [Term] id: GO:1903976 name: negative regulation of glial cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie] synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie] synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008347 ! negatively regulates glial cell migration relationship: RO:0002212 GO:0008347 ! negatively regulates glial cell migration creation_date: 2015-03-02T15:13:38Z [Term] id: GO:1903977 name: positive regulation of glial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of glia cell migration" NARROW [GOC:TermGenie] synonym: "activation of glial cell migration" NARROW [GOC:TermGenie] synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008347 ! positively regulates glial cell migration relationship: RO:0002213 GO:0008347 ! positively regulates glial cell migration creation_date: 2015-03-02T15:13:43Z [Term] id: GO:1903978 name: regulation of microglial cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0043030 ! regulation of macrophage activation is_a: GO:0150077 ! regulation of neuroinflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001774 ! regulates microglial cell activation relationship: RO:0002211 GO:0001774 ! regulates microglial cell activation creation_date: 2015-03-02T15:17:33Z [Term] id: GO:1903979 name: negative regulation of microglial cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie] is_a: GO:0043031 ! negative regulation of macrophage activation is_a: GO:0150079 ! negative regulation of neuroinflammatory response is_a: GO:1903978 ! regulation of microglial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001774 ! negatively regulates microglial cell activation relationship: RO:0002212 GO:0001774 ! negatively regulates microglial cell activation creation_date: 2015-03-02T15:17:39Z [Term] id: GO:1903980 name: positive regulation of microglial cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie] is_a: GO:0043032 ! positive regulation of macrophage activation is_a: GO:0150078 ! positive regulation of neuroinflammatory response is_a: GO:1903978 ! regulation of microglial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001774 ! positively regulates microglial cell activation relationship: RO:0002213 GO:0001774 ! positively regulates microglial cell activation creation_date: 2015-03-02T15:17:44Z [Term] id: GO:1904014 name: response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071867 ! response to monoamine is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:350546 ! has primary input relationship: RO:0004009 CHEBI:350546 ! has primary input creation_date: 2015-03-06T19:33:54Z [Term] id: GO:1904015 name: cellular response to serotonin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] is_a: GO:0071868 ! cellular response to monoamine stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904014 ! response to serotonin intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:350546 ! has primary input creation_date: 2015-03-06T19:34:00Z [Term] id: GO:1904018 name: positive regulation of vasculature development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453] synonym: "activation of vascular system development" RELATED [GOC:TermGenie] synonym: "activation of vasculature development" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie] synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie] synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie] synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001944 ! positively regulates vasculature development relationship: RO:0002213 GO:0001944 ! positively regulates vasculature development creation_date: 2015-03-06T22:17:04Z [Term] id: GO:1904019 name: epithelial cell apoptotic process namespace: biological_process def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell creation_date: 2015-03-06T22:27:17Z [Term] id: GO:1904026 name: regulation of collagen fibril organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "regulation of collagen fibrillogenesis" RELATED [] synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1903053 ! regulation of extracellular matrix organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030199 ! regulates collagen fibril organization relationship: RO:0002211 GO:0030199 ! regulates collagen fibril organization creation_date: 2015-03-12T12:36:52Z [Term] id: GO:1904027 name: negative regulation of collagen fibril organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization relationship: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization creation_date: 2015-03-12T12:36:59Z [Term] id: GO:1904028 name: positive regulation of collagen fibril organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie] synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie] synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie] synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie] synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie] synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1904026 ! regulation of collagen fibril organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization relationship: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization creation_date: 2015-03-12T12:37:06Z [Term] id: GO:1904035 name: regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process relationship: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process creation_date: 2015-03-13T22:05:41Z [Term] id: GO:1904036 name: negative regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process relationship: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process creation_date: 2015-03-13T22:05:47Z [Term] id: GO:1904037 name: positive regulation of epithelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904035 ! regulation of epithelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process relationship: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process creation_date: 2015-03-13T22:05:53Z [Term] id: GO:1904057 name: negative regulation of sensory perception of pain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "down regulation of nociception" EXACT [GOC:TermGenie] synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "down-regulation of nociception" EXACT [GOC:TermGenie] synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "downregulation of nociception" EXACT [GOC:TermGenie] synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "inhibition of nociception" NARROW [GOC:TermGenie] synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "negative regulation of nociception" EXACT [GOC:TermGenie] synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie] is_a: GO:0031645 ! negative regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain relationship: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain creation_date: 2015-03-18T20:33:57Z [Term] id: GO:1904058 name: positive regulation of sensory perception of pain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] synonym: "activation of nociception" NARROW [GOC:TermGenie] synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie] synonym: "positive regulation of nociception" EXACT [GOC:TermGenie] synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of nociception" EXACT [GOC:TermGenie] synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "up-regulation of nociception" EXACT [GOC:TermGenie] synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie] synonym: "upregulation of nociception" EXACT [GOC:TermGenie] synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie] synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie] is_a: GO:0031646 ! positive regulation of nervous system process is_a: GO:0051930 ! regulation of sensory perception of pain intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain relationship: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain creation_date: 2015-03-18T20:34:03Z [Term] id: GO:1904065 name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:22588719] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway intersection_of: BFO:0000050 GO:0014057 ! part of positive regulation of acetylcholine secretion, neurotransmission relationship: BFO:0000050 GO:0014057 ! part of positive regulation of acetylcholine secretion, neurotransmission creation_date: 2015-03-19T15:28:47Z [Term] id: GO:1904073 name: regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation relationship: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation creation_date: 2015-03-20T16:55:56Z [Term] id: GO:1904074 name: negative regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation relationship: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation creation_date: 2015-03-20T16:56:02Z [Term] id: GO:1904075 name: positive regulation of trophectodermal cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:1904073 ! regulation of trophectodermal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation relationship: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation creation_date: 2015-03-20T16:56:08Z [Term] id: GO:1904092 name: regulation of autophagic cell death namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] synonym: "regulation of autophagic death" BROAD [GOC:TermGenie] synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie] synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie] is_a: GO:0043067 ! regulation of programmed cell death intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048102 ! regulates autophagic cell death relationship: RO:0002211 GO:0048102 ! regulates autophagic cell death created_by: bhm creation_date: 2015-03-26T16:41:32Z [Term] id: GO:1904106 name: protein localization to microvillus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie] synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie] synonym: "protein localization in microvillus" EXACT [GOC:TermGenie] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005902 ! has target end location microvillus relationship: RO:0002339 GO:0005902 ! has target end location microvillus creation_date: 2015-04-01T18:14:41Z [Term] id: GO:1904115 name: axon cytoplasm namespace: cellular_component def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] synonym: "axoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0030424 ! part of axon relationship: BFO:0000050 GO:0030424 ! part of axon creation_date: 2015-04-06T18:13:14Z [Term] id: GO:1904116 name: response to vasopressin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] is_a: GO:0043434 ! response to peptide hormone intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:9937 ! has primary input relationship: RO:0004009 CHEBI:9937 ! has primary input creation_date: 2015-04-06T19:39:42Z [Term] id: GO:1904117 name: cellular response to vasopressin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] is_a: GO:0071375 ! cellular response to peptide hormone stimulus is_a: GO:1904116 ! response to vasopressin intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:9937 ! has primary input creation_date: 2015-04-06T19:39:48Z [Term] id: GO:1904124 name: microglial cell migration namespace: biological_process def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:0008347 ! glial cell migration is_a: GO:1905517 ! macrophage migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000129 ! results in movement of microglial cell relationship: RO:0002565 CL:0000129 ! results in movement of microglial cell creation_date: 2015-04-10T16:04:49Z [Term] id: GO:1904139 name: regulation of microglial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] is_a: GO:1903975 ! regulation of glial cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904124 ! regulates microglial cell migration relationship: RO:0002211 GO:1904124 ! regulates microglial cell migration creation_date: 2015-04-13T09:06:57Z [Term] id: GO:1904140 name: negative regulation of microglial cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie] is_a: GO:1903976 ! negative regulation of glial cell migration is_a: GO:1904139 ! regulation of microglial cell migration is_a: GO:1905522 ! negative regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904124 ! negatively regulates microglial cell migration relationship: RO:0002212 GO:1904124 ! negatively regulates microglial cell migration creation_date: 2015-04-13T09:07:03Z [Term] id: GO:1904141 name: positive regulation of microglial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie] is_a: GO:1903977 ! positive regulation of glial cell migration is_a: GO:1904139 ! regulation of microglial cell migration is_a: GO:1905523 ! positive regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904124 ! positively regulates microglial cell migration relationship: RO:0002213 GO:1904124 ! positively regulates microglial cell migration creation_date: 2015-04-13T09:07:11Z [Term] id: GO:1904145 name: negative regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1900194 ! negative regulation of oocyte maturation is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation creation_date: 2015-04-14T15:59:22Z [Term] id: GO:1904146 name: positive regulation of meiotic cell cycle process involved in oocyte maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] is_a: GO:0051446 ! positive regulation of meiotic cell cycle is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation relationship: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation creation_date: 2015-04-14T15:59:28Z [Term] id: GO:1904170 name: regulation of bleb assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032060 ! regulates bleb assembly relationship: RO:0002211 GO:0032060 ! regulates bleb assembly creation_date: 2015-04-23T09:32:19Z [Term] id: GO:1904171 name: negative regulation of bleb assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie] synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0032060 ! negatively regulates bleb assembly relationship: RO:0002212 GO:0032060 ! negatively regulates bleb assembly creation_date: 2015-04-23T09:32:25Z [Term] id: GO:1904172 name: positive regulation of bleb assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] synonym: "activation of bleb assembly" NARROW [GOC:TermGenie] synonym: "activation of cell blebbing" NARROW [GOC:TermGenie] synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie] synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1904170 ! regulation of bleb assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0032060 ! positively regulates bleb assembly relationship: RO:0002213 GO:0032060 ! positively regulates bleb assembly creation_date: 2015-04-23T09:32:31Z [Term] id: GO:1904177 name: regulation of adipose tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie] xref: Reactome:R-HSA-9843745 "Adipogenesis" is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060612 ! regulates adipose tissue development relationship: RO:0002211 GO:0060612 ! regulates adipose tissue development creation_date: 2015-04-29T20:01:01Z [Term] id: GO:1904178 name: negative regulation of adipose tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie] synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development relationship: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development creation_date: 2015-04-29T20:01:07Z [Term] id: GO:1904179 name: positive regulation of adipose tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] synonym: "activation of adipogenesis" RELATED [GOC:TermGenie] synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie] synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904177 ! regulation of adipose tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060612 ! positively regulates adipose tissue development relationship: RO:0002213 GO:0060612 ! positively regulates adipose tissue development creation_date: 2015-04-29T20:01:13Z [Term] id: GO:1904204 name: regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] is_a: GO:0014733 ! regulation of skeletal muscle adaptation is_a: GO:0014743 ! regulation of muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy relationship: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy creation_date: 2015-05-08T17:38:13Z [Term] id: GO:1904205 name: negative regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy relationship: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy creation_date: 2015-05-08T17:38:19Z [Term] id: GO:1904206 name: positive regulation of skeletal muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy relationship: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy creation_date: 2015-05-08T17:38:25Z [Term] id: GO:1904215 name: regulation of protein import into chloroplast stroma namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] is_a: GO:0034762 ! regulation of transmembrane transport is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0045037 ! regulates protein import into chloroplast stroma relationship: RO:0002211 GO:0045037 ! regulates protein import into chloroplast stroma creation_date: 2015-05-15T00:47:48Z [Term] id: GO:1904216 name: positive regulation of protein import into chloroplast stroma namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie] synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie] synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:0051222 ! positive regulation of protein transport is_a: GO:1904215 ! regulation of protein import into chloroplast stroma intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045037 ! positively regulates protein import into chloroplast stroma relationship: RO:0002213 GO:0045037 ! positively regulates protein import into chloroplast stroma creation_date: 2015-05-15T00:47:55Z [Term] id: GO:1904266 name: regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1900147 ! regulation of Schwann cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990751 ! regulates Schwann cell chemotaxis relationship: RO:0002211 GO:1990751 ! regulates Schwann cell chemotaxis creation_date: 2015-05-28T17:47:41Z [Term] id: GO:1904267 name: negative regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1900148 ! negative regulation of Schwann cell migration is_a: GO:1904266 ! regulation of Schwann cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990751 ! negatively regulates Schwann cell chemotaxis relationship: RO:0002212 GO:1990751 ! negatively regulates Schwann cell chemotaxis creation_date: 2015-05-28T17:47:48Z [Term] id: GO:1904268 name: positive regulation of Schwann cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie] synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1900149 ! positive regulation of Schwann cell migration is_a: GO:1904266 ! regulation of Schwann cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990751 ! positively regulates Schwann cell chemotaxis relationship: RO:0002213 GO:1990751 ! positively regulates Schwann cell chemotaxis creation_date: 2015-05-28T17:47:55Z [Term] id: GO:1904269 name: cell leading edge cell cortex namespace: cellular_component def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030] synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie] synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie] synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie] synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie] synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie] synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie] synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: BFO:0000050 GO:0031252 ! part of cell leading edge relationship: BFO:0000050 GO:0031252 ! part of cell leading edge creation_date: 2015-05-28T19:16:03Z [Term] id: GO:1904350 name: regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole relationship: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole creation_date: 2015-06-12T09:10:36Z [Term] id: GO:1904351 name: negative regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole relationship: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole creation_date: 2015-06-12T09:10:42Z [Term] id: GO:1904352 name: positive regulation of protein catabolic process in the vacuole namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole relationship: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole creation_date: 2015-06-12T09:10:49Z [Term] id: GO:1904359 name: regulation of spore germination namespace: biological_process alt_id: GO:0075006 def: "Any process that modulates the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] synonym: "modulation of spore germination on or near host" NARROW [] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009847 ! regulates spore germination relationship: RO:0002211 GO:0009847 ! regulates spore germination created_by: pf creation_date: 2015-06-12T19:46:06Z [Term] id: GO:1904375 name: regulation of protein localization to cell periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery relationship: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery created_by: sl creation_date: 2015-06-22T22:09:25Z [Term] id: GO:1904376 name: negative regulation of protein localization to cell periphery namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery relationship: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery creation_date: 2015-06-22T22:09:32Z [Term] id: GO:1904377 name: positive regulation of protein localization to cell periphery namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery relationship: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery creation_date: 2015-06-22T22:09:37Z [Term] id: GO:1904396 name: regulation of neuromuscular junction development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007528 ! regulates neuromuscular junction development relationship: RO:0002211 GO:0007528 ! regulates neuromuscular junction development creation_date: 2015-06-23T19:23:42Z [Term] id: GO:1904397 name: negative regulation of neuromuscular junction development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:1904396 ! regulation of neuromuscular junction development is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development relationship: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development creation_date: 2015-06-23T19:23:48Z [Term] id: GO:1904398 name: positive regulation of neuromuscular junction development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie] synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "activation of NMJ stability" RELATED [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie] synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1904396 ! regulation of neuromuscular junction development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development relationship: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development creation_date: 2015-06-23T19:23:54Z [Term] id: GO:1904408 name: melatonin binding namespace: molecular_function def: "Binding to melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923] is_a: GO:0033218 ! amide binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:16796 ! has primary input relationship: RO:0004009 CHEBI:16796 ! has primary input creation_date: 2015-06-25T19:19:53Z [Term] id: GO:1904409 name: regulation of secretory granule organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033363 ! regulates secretory granule organization relationship: RO:0002211 GO:0033363 ! regulates secretory granule organization creation_date: 2015-06-25T19:40:42Z [Term] id: GO:1904410 name: negative regulation of secretory granule organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie] synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization relationship: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization creation_date: 2015-06-25T19:40:49Z [Term] id: GO:1904411 name: positive regulation of secretory granule organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie] synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie] synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1904409 ! regulation of secretory granule organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033363 ! positively regulates secretory granule organization relationship: RO:0002213 GO:0033363 ! positively regulates secretory granule organization creation_date: 2015-06-25T19:40:55Z [Term] id: GO:1904412 name: regulation of cardiac ventricle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003231 ! regulates cardiac ventricle development relationship: RO:0002211 GO:0003231 ! regulates cardiac ventricle development creation_date: 2015-06-25T19:52:15Z [Term] id: GO:1904413 name: negative regulation of cardiac ventricle development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development relationship: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development creation_date: 2015-06-25T19:52:21Z [Term] id: GO:1904414 name: positive regulation of cardiac ventricle development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1904412 ! regulation of cardiac ventricle development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development relationship: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development creation_date: 2015-06-25T19:52:27Z [Term] id: GO:1904456 name: negative regulation of neuronal action potential namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie] synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie] synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie] is_a: GO:0045759 ! negative regulation of action potential is_a: GO:0051970 ! negative regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential relationship: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential creation_date: 2015-07-09T18:02:40Z [Term] id: GO:1904457 name: positive regulation of neuronal action potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] synonym: "activation of generation of action potential" RELATED [GOC:TermGenie] synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie] synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie] synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie] synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie] is_a: GO:0045760 ! positive regulation of action potential is_a: GO:0051971 ! positive regulation of transmission of nerve impulse is_a: GO:0098908 ! regulation of neuronal action potential intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0019228 ! positively regulates neuronal action potential relationship: RO:0002213 GO:0019228 ! positively regulates neuronal action potential creation_date: 2015-07-09T18:02:46Z [Term] id: GO:1904491 name: protein localization to ciliary transition zone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230] synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie] synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie] is_a: GO:0061512 ! protein localization to cilium intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0035869 ! has target end location ciliary transition zone relationship: RO:0002339 GO:0035869 ! has target end location ciliary transition zone creation_date: 2015-07-17T20:43:21Z [Term] id: GO:1904587 name: response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "response to glycoproteins" EXACT [] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:17089 ! has primary input relationship: RO:0004009 CHEBI:17089 ! has primary input creation_date: 2015-08-20T16:46:24Z [Term] id: GO:1904588 name: cellular response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "cellular response to glycoproteins" EXACT [] is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904587 ! response to glycoprotein intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:17089 ! has primary input creation_date: 2015-08-20T16:46:30Z [Term] id: GO:1904606 name: fat cell apoptotic process namespace: biological_process def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416] synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000136 ! occurs in adipocyte relationship: BFO:0000066 CL:0000136 ! occurs in adipocyte creation_date: 2015-08-27T18:13:06Z [Term] id: GO:1904624 name: regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061537 ! regulates glycine secretion, neurotransmission relationship: RO:0002211 GO:0061537 ! regulates glycine secretion, neurotransmission creation_date: 2015-08-27T20:03:38Z [Term] id: GO:1904625 name: negative regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061537 ! negatively regulates glycine secretion, neurotransmission relationship: RO:0002212 GO:0061537 ! negatively regulates glycine secretion, neurotransmission creation_date: 2015-08-27T20:03:44Z [Term] id: GO:1904626 name: positive regulation of glycine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061537 ! positively regulates glycine secretion, neurotransmission relationship: RO:0002213 GO:0061537 ! positively regulates glycine secretion, neurotransmission creation_date: 2015-08-27T20:03:49Z [Term] id: GO:1904649 name: regulation of fat cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process relationship: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process creation_date: 2015-08-31T20:59:28Z [Term] id: GO:1904650 name: negative regulation of fat cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process relationship: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process creation_date: 2015-08-31T20:59:34Z [Term] id: GO:1904651 name: positive regulation of fat cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:1904649 ! regulation of fat cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process relationship: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process creation_date: 2015-08-31T20:59:40Z [Term] id: GO:1904675 name: regulation of somatic stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:2000035 ! regulation of stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048103 ! regulates somatic stem cell division relationship: RO:0002211 GO:0048103 ! regulates somatic stem cell division creation_date: 2015-09-14T08:47:22Z [Term] id: GO:1904676 name: negative regulation of somatic stem cell division namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051782 ! negative regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division relationship: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division creation_date: 2015-09-14T08:47:28Z [Term] id: GO:1904677 name: positive regulation of somatic stem cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie] synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie] synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie] synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] is_a: GO:0051781 ! positive regulation of cell division is_a: GO:1904675 ! regulation of somatic stem cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division relationship: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division creation_date: 2015-09-14T08:47:34Z [Term] id: GO:1904680 name: peptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw] synonym: "peptide transporter activity" RELATED [] synonym: "peptide uptake permease activity" RELATED [] xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium" is_a: GO:0022857 ! transmembrane transporter activity intersection_of: GO:0005215 ! transporter activity intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion creation_date: 2015-09-22T18:50:41Z [Term] id: GO:1904688 name: regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation relationship: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation creation_date: 2015-09-25T14:39:38Z [Term] id: GO:1904689 name: negative regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie] is_a: GO:0045947 ! negative regulation of translational initiation is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation relationship: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation creation_date: 2015-09-25T14:39:44Z [Term] id: GO:1904690 name: positive regulation of cytoplasmic translational initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie] synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] is_a: GO:0045948 ! positive regulation of translational initiation is_a: GO:1904688 ! regulation of cytoplasmic translational initiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002183 ! positively regulates cytoplasmic translational initiation relationship: RO:0002213 GO:0002183 ! positively regulates cytoplasmic translational initiation creation_date: 2015-09-25T14:39:50Z [Term] id: GO:1904693 name: midbrain morphogenesis namespace: biological_process def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] synonym: "MB morphogenesis" BROAD [GOC:TermGenie] synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain relationship: BFO:0000050 GO:0030901 ! part of midbrain development relationship: BFO:0000050 GO:0048854 ! part of brain morphogenesis relationship: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain creation_date: 2015-09-29T09:15:28Z [Term] id: GO:1904697 name: regulation of acinar cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990863 ! regulates acinar cell proliferation relationship: RO:0002211 GO:1990863 ! regulates acinar cell proliferation creation_date: 2015-09-30T15:19:50Z [Term] id: GO:1904698 name: negative regulation of acinar cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation relationship: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation creation_date: 2015-09-30T15:19:57Z [Term] id: GO:1904699 name: positive regulation of acinar cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0050679 ! positive regulation of epithelial cell proliferation is_a: GO:1904697 ! regulation of acinar cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation relationship: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation creation_date: 2015-09-30T15:20:03Z [Term] id: GO:1904705 name: regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation relationship: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation creation_date: 2015-10-01T16:05:20Z [Term] id: GO:1904706 name: negative regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation relationship: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation creation_date: 2015-10-01T16:05:26Z [Term] id: GO:1904707 name: positive regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation relationship: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation creation_date: 2015-10-01T16:05:32Z [Term] id: GO:1904738 name: vascular associated smooth muscle cell migration namespace: biological_process def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "vascular smooth muscle cell migration" EXACT [] is_a: GO:0014909 ! smooth muscle cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000359 ! results in movement of vascular associated smooth muscle cell relationship: RO:0002565 CL:0000359 ! results in movement of vascular associated smooth muscle cell creation_date: 2015-10-15T09:56:00Z [Term] id: GO:1904745 name: Atg1/ULK1 kinase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988] synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0065003 ! protein-containing complex assembly created_by: dph creation_date: 2015-10-19T12:33:08Z [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development relationship: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development creation_date: 2015-10-19T14:12:27Z [Term] id: GO:1904747 name: positive regulation of apoptotic process involved in development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: U4PR86 in PMID:22801495 inferred from mutant phenotype synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1904748 ! regulation of apoptotic process involved in development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development relationship: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development creation_date: 2015-10-19T14:12:34Z [Term] id: GO:1904748 name: regulation of apoptotic process involved in development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] comment: Q10943 in PMID:22801495, inferred from mutant phenotype synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] is_a: GO:0042981 ! regulation of apoptotic process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development relationship: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development creation_date: 2015-10-19T15:02:28Z [Term] id: GO:1904749 name: regulation of protein localization to nucleolus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900180 ! regulation of protein localization to nucleus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus relationship: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus creation_date: 2015-10-19T15:16:17Z [Term] id: GO:1904750 name: negative regulation of protein localization to nucleolus namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900181 ! negative regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus relationship: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus creation_date: 2015-10-19T15:16:24Z [Term] id: GO:1904751 name: positive regulation of protein localization to nucleolus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie] synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] is_a: GO:1900182 ! positive regulation of protein localization to nucleus is_a: GO:1904749 ! regulation of protein localization to nucleolus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus relationship: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus creation_date: 2015-10-19T15:16:30Z [Term] id: GO:1904752 name: regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014910 ! regulation of smooth muscle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904738 ! regulates vascular associated smooth muscle cell migration relationship: RO:0002211 GO:1904738 ! regulates vascular associated smooth muscle cell migration creation_date: 2015-10-19T15:49:52Z [Term] id: GO:1904753 name: negative regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014912 ! negative regulation of smooth muscle cell migration is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1904738 ! negatively regulates vascular associated smooth muscle cell migration relationship: RO:0002212 GO:1904738 ! negatively regulates vascular associated smooth muscle cell migration creation_date: 2015-10-19T15:49:58Z [Term] id: GO:1904754 name: positive regulation of vascular associated smooth muscle cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] is_a: GO:0014911 ! positive regulation of smooth muscle cell migration is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1904738 ! positively regulates vascular associated smooth muscle cell migration relationship: RO:0002213 GO:1904738 ! positively regulates vascular associated smooth muscle cell migration creation_date: 2015-10-19T15:50:05Z [Term] id: GO:1904770 name: intramembranous bone morphogenesis namespace: biological_process def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686] synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie] synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie] is_a: GO:0060349 ! bone morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone relationship: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone creation_date: 2015-10-28T11:46:04Z [Term] id: GO:1904776 name: regulation of protein localization to cell cortex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex relationship: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex created_by: es creation_date: 2015-10-29T16:55:01Z [Term] id: GO:1904777 name: negative regulation of protein localization to cell cortex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904376 ! negative regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex relationship: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex creation_date: 2015-10-29T16:55:08Z [Term] id: GO:1904778 name: positive regulation of protein localization to cell cortex namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] is_a: GO:1904377 ! positive regulation of protein localization to cell periphery is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex relationship: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex creation_date: 2015-10-29T16:55:15Z [Term] id: GO:1904809 name: regulation of dense core granule transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0032386 ! regulation of intracellular transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1901950 ! regulates dense core granule transport relationship: RO:0002211 GO:1901950 ! regulates dense core granule transport creation_date: 2015-11-11T10:40:10Z [Term] id: GO:1904810 name: negative regulation of dense core granule transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie] synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie] synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1901950 ! negatively regulates dense core granule transport relationship: RO:0002212 GO:1901950 ! negatively regulates dense core granule transport creation_date: 2015-11-11T10:40:18Z [Term] id: GO:1904811 name: positive regulation of dense core granule transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie] synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie] synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie] synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:1904809 ! regulation of dense core granule transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1901950 ! positively regulates dense core granule transport relationship: RO:0002213 GO:1901950 ! positively regulates dense core granule transport creation_date: 2015-11-11T10:40:25Z [Term] id: GO:1904817 name: serous membrane development namespace: biological_process def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "serosa development" RELATED [GOC:TermGenie] synonym: "tunica serosa development" EXACT [GOC:TermGenie] synonym: "wall of serous sac development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000042 ! results in development of serous membrane relationship: RO:0002296 UBERON:0000042 ! results in development of serous membrane creation_date: 2015-11-17T19:00:01Z [Term] id: GO:1904818 name: visceral peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum relationship: BFO:0000050 GO:1904820 ! part of peritoneum development relationship: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum creation_date: 2015-11-17T19:00:17Z [Term] id: GO:1904819 name: parietal peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum relationship: BFO:0000050 GO:1904820 ! part of peritoneum development relationship: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum creation_date: 2015-11-17T19:00:24Z [Term] id: GO:1904820 name: peritoneum development namespace: biological_process def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] synonym: "peritonaeum development" RELATED [GOC:TermGenie] is_a: GO:1904817 ! serous membrane development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002358 ! results in development of peritoneum relationship: RO:0002296 UBERON:0002358 ! results in development of peritoneum creation_date: 2015-11-18T17:23:51Z [Term] id: GO:1904821 name: chloroplast disassembly namespace: biological_process def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759] comment: The disaggregation of a chloroplast into its constituent components. synonym: "chloroplast degradation" RELATED [PMID:26494759] is_a: GO:0009658 ! chloroplast organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0009507 ! results in disassembly of chloroplast relationship: RO:0002590 GO:0009507 ! results in disassembly of chloroplast creation_date: 2015-11-19T00:41:18Z [Term] id: GO:1904829 name: regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation relationship: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation creation_date: 2015-11-24T10:20:40Z [Term] id: GO:1904830 name: negative regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation relationship: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation creation_date: 2015-11-24T10:20:47Z [Term] id: GO:1904831 name: positive regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation relationship: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation creation_date: 2015-11-24T10:20:54Z [Term] id: GO:1904888 name: cranial skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227] synonym: "cranial skeleton development" NARROW [GOC:TermGenie] synonym: "craniofacial development" NARROW [PMID:11262227] synonym: "cranium development" RELATED [GOC:TermGenie] synonym: "osteocranium development" NARROW [GOC:TermGenie] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system relationship: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system creation_date: 2016-01-07T13:45:06Z [Term] id: GO:1904933 name: regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain relationship: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain creation_date: 2016-02-01T13:16:11Z [Term] id: GO:1904934 name: negative regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain relationship: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain creation_date: 2016-02-01T13:16:19Z [Term] id: GO:1904935 name: positive regulation of cell proliferation in midbrain namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie] synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] is_a: GO:1904933 ! regulation of cell proliferation in midbrain is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain relationship: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain creation_date: 2016-02-01T13:16:27Z [Term] id: GO:1904936 name: interneuron migration namespace: biological_process def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] synonym: "inter neuron migration" EXACT [GOC:ah] synonym: "inter-neuron migration" EXACT [GOC:ah] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000099 ! results in movement of interneuron relationship: RO:0002565 CL:0000099 ! results in movement of interneuron creation_date: 2016-02-01T14:04:32Z [Term] id: GO:1904937 name: sensory neuron migration namespace: biological_process def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] is_a: GO:0001764 ! neuron migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000101 ! results in movement of sensory neuron relationship: RO:0002565 CL:0000101 ! results in movement of sensory neuron creation_date: 2016-02-01T14:15:50Z [Term] id: GO:1904942 name: regulation of cardiac ventricle formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] is_a: GO:1901210 ! regulation of cardiac chamber formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation relationship: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation creation_date: 2016-02-02T16:37:16Z [Term] id: GO:1904943 name: negative regulation of cardiac ventricle formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie] is_a: GO:1901211 ! negative regulation of cardiac chamber formation is_a: GO:1904413 ! negative regulation of cardiac ventricle development is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation relationship: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation creation_date: 2016-02-02T16:37:24Z [Term] id: GO:1904944 name: positive regulation of cardiac ventricle formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] is_a: GO:1901212 ! positive regulation of cardiac chamber formation is_a: GO:1904942 ! regulation of cardiac ventricle formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation relationship: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation creation_date: 2016-02-02T16:37:31Z [Term] id: GO:1904950 name: negative regulation of establishment of protein localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization relationship: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization creation_date: 2016-02-05T09:59:24Z [Term] id: GO:1904951 name: positive regulation of establishment of protein localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] synonym: "activation of protein positioning" NARROW [GOC:TermGenie] synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] is_a: GO:0070201 ! regulation of establishment of protein localization is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization relationship: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization creation_date: 2016-02-05T09:59:32Z [Term] id: GO:1904962 name: plastid to vacuole vesicle-mediated transport namespace: biological_process def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689] synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0016482 ! cytosolic transport intersection_of: GO:0016192 ! vesicle-mediated transport intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol intersection_of: RO:0002338 GO:0009536 ! has target start location plastid intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole relationship: RO:0002338 GO:0009536 ! has target start location plastid relationship: RO:0002339 GO:0005773 ! has target end location vacuole creation_date: 2016-02-10T00:14:48Z [Term] id: GO:1904970 name: brush border assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409] synonym: "brush border formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0005903 ! results in assembly of brush border relationship: RO:0002588 GO:0005903 ! results in assembly of brush border creation_date: 2016-02-17T00:58:30Z [Term] id: GO:1904983 name: glycine import into mitochondrion namespace: biological_process def: "The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380] synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015816 ! glycine transport is_a: GO:0170036 ! import into the mitochondrion is_a: GO:1905039 ! carboxylic acid transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2016-02-28T21:53:44Z [Term] id: GO:1904987 name: regulation of endothelial cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042118 ! regulates endothelial cell activation relationship: RO:0002211 GO:0042118 ! regulates endothelial cell activation creation_date: 2016-02-29T16:16:09Z [Term] id: GO:1904988 name: negative regulation of endothelial cell activation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie] is_a: GO:0050866 ! negative regulation of cell activation is_a: GO:1904987 ! regulation of endothelial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042118 ! negatively regulates endothelial cell activation relationship: RO:0002212 GO:0042118 ! negatively regulates endothelial cell activation creation_date: 2016-02-29T16:16:18Z [Term] id: GO:1904989 name: positive regulation of endothelial cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie] is_a: GO:0050867 ! positive regulation of cell activation is_a: GO:1904987 ! regulation of endothelial cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042118 ! positively regulates endothelial cell activation relationship: RO:0002213 GO:0042118 ! positively regulates endothelial cell activation creation_date: 2016-02-29T16:16:25Z [Term] id: GO:1905037 name: autophagosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie] synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie] is_a: GO:0007033 ! vacuole organization relationship: BFO:0000050 GO:0016236 ! part of macroautophagy created_by: bf creation_date: 2016-03-08T14:18:10Z [Term] id: GO:1905038 name: regulation of membrane lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280] synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie] is_a: GO:0019216 ! regulation of lipid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process relationship: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process creation_date: 2016-03-08T20:41:32Z [Term] id: GO:1905039 name: carboxylic acid transmembrane transport namespace: biological_process def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1903825 ! organic acid transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion creation_date: 2016-03-09T15:33:53Z [Term] id: GO:1905063 name: regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation relationship: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation creation_date: 2016-03-21T11:14:53Z [Term] id: GO:1905064 name: negative regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation relationship: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation creation_date: 2016-03-21T11:15:03Z [Term] id: GO:1905065 name: positive regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation relationship: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation creation_date: 2016-03-21T11:15:13Z [Term] id: GO:1905071 name: tight junction disassembly namespace: biological_process def: "The disaggregation of an tight junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "occluding junction disassembly" EXACT [] is_a: GO:0120193 ! tight junction organization is_a: GO:0150147 ! cell-cell junction disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0070160 ! results in disassembly of tight junction relationship: RO:0002590 GO:0070160 ! results in disassembly of tight junction creation_date: 2016-03-23T12:35:08Z [Term] id: GO:1905073 name: regulation of tight junction disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "regulation of occluding junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905071 ! regulates tight junction disassembly relationship: RO:0002211 GO:1905071 ! regulates tight junction disassembly creation_date: 2016-03-23T19:32:51Z [Term] id: GO:1905074 name: negative regulation of tight junction disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "down regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie] synonym: "inhibition of tight junction disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905073 ! regulation of tight junction disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905071 ! negatively regulates tight junction disassembly relationship: RO:0002212 GO:1905071 ! negatively regulates tight junction disassembly creation_date: 2016-03-23T19:33:01Z [Term] id: GO:1905075 name: positive regulation of tight junction disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie] synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie] synonym: "activation of tight junction disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "positive regulation of occluding junction disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "up regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of tight junction disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of tight junction disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905073 ! regulation of tight junction disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905071 ! positively regulates tight junction disassembly relationship: RO:0002213 GO:1905071 ! positively regulates tight junction disassembly creation_date: 2016-03-23T19:33:10Z [Term] id: GO:1905079 name: regulation of cerebellar neuron development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098749 ! regulates cerebellar neuron development relationship: RO:0002211 GO:0098749 ! regulates cerebellar neuron development creation_date: 2016-03-24T19:45:17Z [Term] id: GO:1905080 name: negative regulation of cerebellar neuron development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1905079 ! regulation of cerebellar neuron development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098749 ! negatively regulates cerebellar neuron development relationship: RO:0002212 GO:0098749 ! negatively regulates cerebellar neuron development creation_date: 2016-03-24T19:45:26Z [Term] id: GO:1905081 name: positive regulation of cerebellar neuron development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie] synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1905079 ! regulation of cerebellar neuron development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098749 ! positively regulates cerebellar neuron development relationship: RO:0002213 GO:0098749 ! positively regulates cerebellar neuron development creation_date: 2016-03-24T19:45:35Z [Term] id: GO:1905082 name: regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] is_a: GO:0006448 ! regulation of translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070125 ! regulates mitochondrial translational elongation relationship: RO:0002211 GO:0070125 ! regulates mitochondrial translational elongation creation_date: 2016-03-25T17:37:03Z [Term] id: GO:1905083 name: negative regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie] synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie] synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] is_a: GO:0045900 ! negative regulation of translational elongation is_a: GO:0070130 ! negative regulation of mitochondrial translation is_a: GO:1905082 ! regulation of mitochondrial translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0070125 ! negatively regulates mitochondrial translational elongation relationship: RO:0002212 GO:0070125 ! negatively regulates mitochondrial translational elongation creation_date: 2016-03-25T17:37:13Z [Term] id: GO:1905084 name: positive regulation of mitochondrial translational elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie] synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie] synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] is_a: GO:0045901 ! positive regulation of translational elongation is_a: GO:1905082 ! regulation of mitochondrial translational elongation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0070125 ! positively regulates mitochondrial translational elongation relationship: RO:0002213 GO:0070125 ! positively regulates mitochondrial translational elongation creation_date: 2016-03-25T17:37:22Z [Term] id: GO:1905126 name: regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0033157 ! regulation of intracellular protein transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport relationship: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport creation_date: 2016-04-11T20:38:31Z [Term] id: GO:1905127 name: negative regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie] synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0090317 ! negative regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport relationship: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport creation_date: 2016-04-11T20:38:40Z [Term] id: GO:1905128 name: positive regulation of axo-dendritic protein transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie] synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie] synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie] is_a: GO:0090316 ! positive regulation of intracellular protein transport is_a: GO:1905126 ! regulation of axo-dendritic protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport relationship: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport creation_date: 2016-04-11T20:38:48Z [Term] id: GO:1905139 name: apical ectodermal ridge formation namespace: biological_process def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583] synonym: "AER formation" RELATED [GOC:TermGenie] synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004356 ! results in formation of apical ectodermal ridge relationship: BFO:0000050 GO:0035107 ! part of appendage morphogenesis relationship: RO:0002297 UBERON:0004356 ! results in formation of apical ectodermal ridge creation_date: 2016-04-13T11:46:40Z [Term] id: GO:1905140 name: regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "regulation of AER formation" RELATED [GOC:TermGenie] synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation relationship: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation creation_date: 2016-04-13T12:16:40Z [Term] id: GO:1905141 name: negative regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "down regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "downregulation of AER formation" RELATED [GOC:TermGenie] synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "inhibition of AER formation" RELATED [GOC:TermGenie] synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie] synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie] synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation relationship: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation creation_date: 2016-04-13T12:16:48Z [Term] id: GO:1905142 name: positive regulation of apical ectodermal ridge formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] synonym: "activation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie] synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie] synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] synonym: "upregulation of AER formation" RELATED [GOC:TermGenie] synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905140 ! regulation of apical ectodermal ridge formation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation relationship: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation creation_date: 2016-04-13T12:16:57Z [Term] id: GO:1905144 name: response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:15355 ! has primary input relationship: RO:0004009 CHEBI:15355 ! has primary input creation_date: 2016-04-14T08:54:49Z [Term] id: GO:1905145 name: cellular response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905144 ! response to acetylcholine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:15355 ! has primary input creation_date: 2016-04-14T08:54:58Z [Term] id: GO:1905146 name: lysosomal protein catabolic process namespace: biological_process def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "cellular protein catabolic process in lysosome" EXACT [] synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "lysosomal protein catabolism" EXACT [GOC:bf] synonym: "lysosomal protein degradation" EXACT [GOC:bf] synonym: "lysosomal proteolysis" RELATED [PMID:24334770] synonym: "proteolysis within lysosome" RELATED [GOC:bf] is_a: GO:0007039 ! protein catabolic process in the vacuole intersection_of: GO:0030163 ! protein catabolic process intersection_of: BFO:0000066 GO:0005764 ! occurs in lysosome relationship: BFO:0000066 GO:0005764 ! occurs in lysosome creation_date: 2016-04-14T12:50:34Z [Term] id: GO:1905147 name: regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy relationship: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy creation_date: 2016-04-15T12:47:07Z [Term] id: GO:1905148 name: negative regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie] is_a: GO:0014741 ! negative regulation of muscle hypertrophy is_a: GO:0014745 ! negative regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy relationship: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy creation_date: 2016-04-15T12:47:16Z [Term] id: GO:1905149 name: positive regulation of smooth muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] is_a: GO:0014742 ! positive regulation of muscle hypertrophy is_a: GO:0014744 ! positive regulation of muscle adaptation is_a: GO:1905147 ! regulation of smooth muscle hypertrophy intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy relationship: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy creation_date: 2016-04-15T12:47:24Z [Term] id: GO:1905153 name: regulation of membrane invagination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010324 ! regulates membrane invagination relationship: RO:0002211 GO:0010324 ! regulates membrane invagination created_by: bf creation_date: 2016-04-18T15:43:54Z [Term] id: GO:1905154 name: negative regulation of membrane invagination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010324 ! negatively regulates membrane invagination relationship: RO:0002212 GO:0010324 ! negatively regulates membrane invagination creation_date: 2016-04-18T15:44:04Z [Term] id: GO:1905155 name: positive regulation of membrane invagination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of membrane invagination" NARROW [GOC:TermGenie] synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie] synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905153 ! regulation of membrane invagination intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010324 ! positively regulates membrane invagination relationship: RO:0002213 GO:0010324 ! positively regulates membrane invagination creation_date: 2016-04-18T15:44:12Z [Term] id: GO:1905165 name: regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937] synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905146 ! regulates lysosomal protein catabolic process relationship: RO:0002211 GO:1905146 ! regulates lysosomal protein catabolic process creation_date: 2016-04-26T12:10:01Z [Term] id: GO:1905166 name: negative regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie] synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole is_a: GO:1905165 ! regulation of lysosomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905146 ! negatively regulates lysosomal protein catabolic process relationship: RO:0002212 GO:1905146 ! negatively regulates lysosomal protein catabolic process creation_date: 2016-04-26T12:10:10Z [Term] id: GO:1905167 name: positive regulation of lysosomal protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie] synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole is_a: GO:1905165 ! regulation of lysosomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905146 ! positively regulates lysosomal protein catabolic process relationship: RO:0002213 GO:1905146 ! positively regulates lysosomal protein catabolic process creation_date: 2016-04-26T12:10:19Z [Term] id: GO:1905192 name: regulation of chloroplast fission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "regulation of chloroplast division" EXACT [GOC:TermGenie] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010020 ! regulates chloroplast fission relationship: RO:0002211 GO:0010020 ! regulates chloroplast fission creation_date: 2016-05-10T19:07:34Z [Term] id: GO:1905193 name: negative regulation of chloroplast fission namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "down regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "down regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "down-regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "down-regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "downregulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "downregulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "inhibition of chloroplast division" NARROW [GOC:TermGenie] synonym: "inhibition of chloroplast fission" NARROW [GOC:TermGenie] synonym: "negative regulation of chloroplast division" EXACT [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905192 ! regulation of chloroplast fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010020 ! negatively regulates chloroplast fission relationship: RO:0002212 GO:0010020 ! negatively regulates chloroplast fission creation_date: 2016-05-10T19:07:43Z [Term] id: GO:1905194 name: positive regulation of chloroplast fission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. synonym: "activation of chloroplast division" NARROW [GOC:TermGenie] synonym: "activation of chloroplast fission" NARROW [GOC:TermGenie] synonym: "positive regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "up-regulation of chloroplast fission" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast division" EXACT [GOC:TermGenie] synonym: "upregulation of chloroplast fission" EXACT [GOC:TermGenie] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:1905192 ! regulation of chloroplast fission intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010020 ! positively regulates chloroplast fission relationship: RO:0002213 GO:0010020 ! positively regulates chloroplast fission creation_date: 2016-05-10T19:07:51Z [Term] id: GO:1905207 name: regulation of cardiocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation relationship: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation creation_date: 2016-06-02T07:20:01Z [Term] id: GO:1905208 name: negative regulation of cardiocyte differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation relationship: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation creation_date: 2016-06-02T07:20:09Z [Term] id: GO:1905209 name: positive regulation of cardiocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie] synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation relationship: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation creation_date: 2016-06-02T07:20:16Z [Term] id: GO:1905213 name: negative regulation of mitotic chromosome condensation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:1902340 ! negative regulation of chromosome condensation is_a: GO:1903379 ! regulation of mitotic chromosome condensation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation relationship: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation creation_date: 2016-06-03T08:41:08Z [Term] id: GO:1905216 name: positive regulation of RNA binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] subset: gocheck_do_not_annotate synonym: "activation of RNA binding" NARROW [GOC:TermGenie] synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie] synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie] is_a: GO:0051099 ! positive regulation of binding intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003723 ! positively regulates RNA binding relationship: RO:0002213 GO:0003723 ! positively regulates RNA binding creation_date: 2016-06-06T10:21:12Z [Term] id: GO:1905223 name: epicardium morphogenesis namespace: biological_process def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie] synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie] synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie] synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium relationship: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium creation_date: 2016-06-07T10:02:32Z [Term] id: GO:1905232 name: cellular response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137] synonym: "cellular response to L-glutamate(1-)" RELATED [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902065 ! response to L-glutamate intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:29985 ! has primary input creation_date: 2016-06-07T17:30:08Z [Term] id: GO:1905268 name: negative regulation of chromatin organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "down regulation of chromatin assembly or disassembly" RELATED [] synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin assembly or disassembly" RELATED [] synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin assembly or disassembly" RELATED [] synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "inhibition of chromatin assembly or disassembly" NARROW [] synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "negative regulation of chromatin assembly or disassembly" RELATED [] synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] synonym: "negative regulation of chromatin modification" RELATED [] synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006325 ! negatively regulates chromatin organization relationship: RO:0002212 GO:0006325 ! negatively regulates chromatin organization creation_date: 2016-06-15T20:14:47Z [Term] id: GO:1905269 name: positive regulation of chromatin organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] synonym: "activation of chromatin assembly or disassembly" NARROW [] synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] synonym: "positive regulation of chromatin assembly or disassembly" RELATED [] synonym: "positive regulation of chromatin assembly/disassembly" RELATED [] synonym: "positive regulation of chromatin modification" RELATED [] synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "stimulation of chromatin assembly or disassembly" NARROW [] synonym: "up regulation of chromatin assembly or disassembly" RELATED [] synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin assembly or disassembly" RELATED [] synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin assembly or disassembly" EXACT [] synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] is_a: GO:1902275 ! regulation of chromatin organization is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006325 ! positively regulates chromatin organization relationship: RO:0002213 GO:0006325 ! positively regulates chromatin organization creation_date: 2016-06-15T20:14:56Z [Term] id: GO:1905276 name: regulation of epithelial tube formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072175 ! regulates epithelial tube formation relationship: RO:0002211 GO:0072175 ! regulates epithelial tube formation creation_date: 2016-06-20T09:35:41Z [Term] id: GO:1905277 name: negative regulation of epithelial tube formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation relationship: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation creation_date: 2016-06-20T09:35:49Z [Term] id: GO:1905278 name: positive regulation of epithelial tube formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie] synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie] synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905276 ! regulation of epithelial tube formation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation relationship: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation creation_date: 2016-06-20T09:35:57Z [Term] id: GO:1905288 name: vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034390 ! smooth muscle cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell relationship: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell creation_date: 2016-06-23T13:24:20Z [Term] id: GO:1905292 name: regulation of neural crest cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation relationship: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation creation_date: 2016-06-28T15:02:01Z [Term] id: GO:1905293 name: negative regulation of neural crest cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000737 ! negative regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation relationship: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation creation_date: 2016-06-28T15:02:09Z [Term] id: GO:1905294 name: positive regulation of neural crest cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905292 ! regulation of neural crest cell differentiation is_a: GO:2000738 ! positive regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation relationship: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation creation_date: 2016-06-28T15:02:16Z [Term] id: GO:1905304 name: regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0060284 ! regulation of cell development is_a: GO:0110020 ! regulation of actomyosin structure organization is_a: GO:1902115 ! regulation of organelle assembly is_a: GO:1902903 ! regulation of supramolecular fiber organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly relationship: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly creation_date: 2016-07-06T10:01:49Z [Term] id: GO:1905305 name: negative regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902116 ! negative regulation of organelle assembly is_a: GO:1902904 ! negative regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly relationship: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly creation_date: 2016-07-06T10:01:58Z [Term] id: GO:1905306 name: positive regulation of cardiac myofibril assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie] synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902117 ! positive regulation of organelle assembly is_a: GO:1902905 ! positive regulation of supramolecular fiber organization is_a: GO:1905304 ! regulation of cardiac myofibril assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly relationship: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly creation_date: 2016-07-06T10:02:07Z [Term] id: GO:1905310 name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003253 ! regulates cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: RO:0002211 GO:0003253 ! regulates cardiac neural crest cell migration involved in outflow tract morphogenesis creation_date: 2016-07-11T17:34:26Z [Term] id: GO:1905311 name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0003253 ! negatively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: RO:0002212 GO:0003253 ! negatively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis creation_date: 2016-07-11T17:34:35Z [Term] id: GO:1905312 name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0003253 ! positively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis relationship: RO:0002213 GO:0003253 ! positively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis creation_date: 2016-07-11T17:34:43Z [Term] id: GO:1905315 name: cell proliferation involved in endocardial cushion morphogenesis namespace: biological_process def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis creation_date: 2016-07-12T13:56:36Z [Term] id: GO:1905319 name: mesenchymal stem cell migration namespace: biological_process def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476] is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000134 ! results in movement of mesenchymal stem cell relationship: RO:0002565 CL:0000134 ! results in movement of mesenchymal stem cell creation_date: 2016-07-14T17:13:02Z [Term] id: GO:1905320 name: regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905319 ! regulates mesenchymal stem cell migration relationship: RO:0002211 GO:1905319 ! regulates mesenchymal stem cell migration creation_date: 2016-07-15T22:19:14Z [Term] id: GO:1905321 name: negative regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:1905320 ! regulation of mesenchymal stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905319 ! negatively regulates mesenchymal stem cell migration relationship: RO:0002212 GO:1905319 ! negatively regulates mesenchymal stem cell migration creation_date: 2016-07-15T22:19:22Z [Term] id: GO:1905322 name: positive regulation of mesenchymal stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie] synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:1905320 ! regulation of mesenchymal stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905319 ! positively regulates mesenchymal stem cell migration relationship: RO:0002213 GO:1905319 ! positively regulates mesenchymal stem cell migration creation_date: 2016-07-15T22:19:29Z [Term] id: GO:1905330 name: regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium relationship: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium creation_date: 2016-07-22T07:13:49Z [Term] id: GO:1905331 name: negative regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium relationship: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium creation_date: 2016-07-22T07:13:57Z [Term] id: GO:1905332 name: positive regulation of morphogenesis of an epithelium namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie] synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium relationship: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium creation_date: 2016-07-22T07:14:05Z [Term] id: GO:1905349 name: ciliary transition zone assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone relationship: BFO:0000050 GO:0060271 ! part of cilium assembly relationship: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone creation_date: 2016-08-04T14:49:43Z [Term] id: GO:1905383 name: protein localization to presynapse namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494] synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494] is_a: GO:0035418 ! protein localization to synapse intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse relationship: RO:0002339 GO:0098793 ! has target end location presynapse creation_date: 2016-08-18T14:42:59Z [Term] id: GO:1905384 name: regulation of protein localization to presynapse namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902473 ! regulation of protein localization to synapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905383 ! regulates protein localization to presynapse relationship: RO:0002211 GO:1905383 ! regulates protein localization to presynapse creation_date: 2016-08-18T14:56:00Z [Term] id: GO:1905385 name: negative regulation of protein localization to presynapse namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse relationship: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse creation_date: 2016-08-18T14:56:08Z [Term] id: GO:1905386 name: positive regulation of protein localization to presynapse namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie] synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie] synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie] synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] is_a: GO:1902474 ! positive regulation of protein localization to synapse is_a: GO:1905384 ! regulation of protein localization to presynapse intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse relationship: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse creation_date: 2016-08-18T14:56:21Z [Term] id: GO:1905429 name: response to glycine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] synonym: "response to aminoacetic acid" EXACT [] synonym: "response to aminoethanoic acid" EXACT [] synonym: "response to Gly" EXACT [] synonym: "response to glycin" EXACT [] is_a: GO:0043200 ! response to amino acid is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 CHEBI:57305 ! has primary input relationship: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2016-09-08T22:09:15Z [Term] id: GO:1905430 name: cellular response to glycine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] synonym: "cellular response to aminoacetic acid" EXACT [] synonym: "cellular response to aminoethanoic acid" EXACT [] synonym: "cellular response to Gly" EXACT [] synonym: "cellular response to glycin" EXACT [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905429 ! response to glycine intersection_of: GO:0070887 ! cellular response to chemical stimulus intersection_of: RO:0004009 CHEBI:57305 ! has primary input creation_date: 2016-09-08T22:09:23Z [Term] id: GO:1905432 name: regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0099177 ! regulation of trans-synaptic signaling intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide creation_date: 2016-09-14T10:56:47Z [Term] id: GO:1905433 name: negative regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide creation_date: 2016-09-14T10:56:55Z [Term] id: GO:1905434 name: positive regulation of retrograde trans-synaptic signaling by neuropeptide namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide relationship: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide creation_date: 2016-09-14T10:57:02Z [Term] id: GO:1905453 name: regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation relationship: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation creation_date: 2016-09-16T12:32:18Z [Term] id: GO:1905454 name: negative regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation relationship: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation creation_date: 2016-09-16T12:32:26Z [Term] id: GO:1905455 name: positive regulation of myeloid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation relationship: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation creation_date: 2016-09-16T12:32:33Z [Term] id: GO:1905456 name: regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002320 ! regulates lymphoid progenitor cell differentiation relationship: RO:0002211 GO:0002320 ! regulates lymphoid progenitor cell differentiation creation_date: 2016-09-16T12:32:40Z [Term] id: GO:1905457 name: negative regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002320 ! negatively regulates lymphoid progenitor cell differentiation relationship: RO:0002212 GO:0002320 ! negatively regulates lymphoid progenitor cell differentiation creation_date: 2016-09-16T12:32:48Z [Term] id: GO:1905458 name: positive regulation of lymphoid progenitor cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002320 ! positively regulates lymphoid progenitor cell differentiation relationship: RO:0002213 GO:0002320 ! positively regulates lymphoid progenitor cell differentiation creation_date: 2016-09-16T12:32:55Z [Term] id: GO:1905459 name: regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process creation_date: 2016-09-19T11:33:54Z [Term] id: GO:1905460 name: negative regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process creation_date: 2016-09-19T11:34:03Z [Term] id: GO:1905461 name: positive regulation of vascular associated smooth muscle cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie] synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process relationship: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process creation_date: 2016-09-19T11:34:10Z [Term] id: GO:1905475 name: regulation of protein localization to membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072657 ! regulates protein localization to membrane relationship: RO:0002211 GO:0072657 ! regulates protein localization to membrane created_by: bc creation_date: 2016-09-21T16:20:03Z [Term] id: GO:1905476 name: negative regulation of protein localization to membrane namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane relationship: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane creation_date: 2016-09-21T16:20:10Z [Term] id: GO:1905477 name: positive regulation of protein localization to membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane relationship: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane creation_date: 2016-09-21T16:20:18Z [Term] id: GO:1905483 name: regulation of motor neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097475 ! regulates motor neuron migration relationship: RO:0002211 GO:0097475 ! regulates motor neuron migration creation_date: 2016-09-23T12:49:54Z [Term] id: GO:1905484 name: negative regulation of motor neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie] is_a: GO:1905483 ! regulation of motor neuron migration is_a: GO:2001223 ! negative regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097475 ! negatively regulates motor neuron migration relationship: RO:0002212 GO:0097475 ! negatively regulates motor neuron migration creation_date: 2016-09-23T12:50:11Z [Term] id: GO:1905485 name: positive regulation of motor neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie] synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie] synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie] is_a: GO:1905483 ! regulation of motor neuron migration is_a: GO:2001224 ! positive regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097475 ! positively regulates motor neuron migration relationship: RO:0002213 GO:0097475 ! positively regulates motor neuron migration creation_date: 2016-09-23T12:50:19Z [Term] id: GO:1905492 name: positive regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie] synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve relationship: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve creation_date: 2016-09-23T14:11:52Z [Term] id: GO:1905503 name: regulation of motile cilium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "regulation of motile primary cilium assembly" RELATED [] synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:1902017 ! regulation of cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044458 ! regulates motile cilium assembly relationship: RO:0002211 GO:0044458 ! regulates motile cilium assembly creation_date: 2016-09-27T18:27:47Z [Term] id: GO:1905504 name: negative regulation of motile cilium assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie] synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "negative regulation of motile primary cilium assembly" RELATED [] synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:1902018 ! negative regulation of cilium assembly is_a: GO:1905503 ! regulation of motile cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044458 ! negatively regulates motile cilium assembly relationship: RO:0002212 GO:0044458 ! negatively regulates motile cilium assembly creation_date: 2016-09-27T18:27:55Z [Term] id: GO:1905505 name: positive regulation of motile cilium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie] synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie] synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "positive regulation of motile primary cilium assembly" RELATED [] synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie] synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie] synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie] is_a: GO:0045724 ! positive regulation of cilium assembly is_a: GO:1905503 ! regulation of motile cilium assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044458 ! positively regulates motile cilium assembly relationship: RO:0002213 GO:0044458 ! positively regulates motile cilium assembly creation_date: 2016-09-27T18:28:03Z [Term] id: GO:1905516 name: positive regulation of fertilization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] synonym: "activation of fertilization" NARROW [GOC:TermGenie] synonym: "activation of syngamy" NARROW [GOC:TermGenie] synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] is_a: GO:0080154 ! regulation of fertilization is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0009566 ! positively regulates fertilization relationship: RO:0002213 GO:0009566 ! positively regulates fertilization creation_date: 2016-09-30T14:32:32Z [Term] id: GO:1905517 name: macrophage migration namespace: biological_process def: "The orderly movement of a macrophage from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:25749876] is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000235 ! results in movement of macrophage relationship: RO:0002565 CL:0000235 ! results in movement of macrophage creation_date: 2016-09-30T22:17:45Z [Term] id: GO:1905521 name: regulation of macrophage migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1905517 ! regulates macrophage migration relationship: RO:0002211 GO:1905517 ! regulates macrophage migration creation_date: 2016-10-03T15:29:06Z [Term] id: GO:1905522 name: negative regulation of macrophage migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] synonym: "down regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "down-regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "downregulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "inhibition of macrophage migration" NARROW [GOC:TermGenie] is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1905517 ! negatively regulates macrophage migration relationship: RO:0002212 GO:1905517 ! negatively regulates macrophage migration creation_date: 2016-10-03T15:29:14Z [Term] id: GO:1905523 name: positive regulation of macrophage migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] synonym: "activation of macrophage migration" NARROW [GOC:TermGenie] synonym: "up regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "up-regulation of macrophage migration" EXACT [GOC:TermGenie] synonym: "upregulation of macrophage migration" EXACT [GOC:TermGenie] is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:1905521 ! regulation of macrophage migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1905517 ! positively regulates macrophage migration relationship: RO:0002213 GO:1905517 ! positively regulates macrophage migration creation_date: 2016-10-03T15:29:21Z [Term] id: GO:1905553 name: regulation of blood vessel branching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:0060688 ! regulation of morphogenesis of a branching structure is_a: GO:1905330 ! regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis relationship: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis creation_date: 2016-10-12T14:19:33Z [Term] id: GO:1905554 name: negative regulation of blood vessel branching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0016525 ! negative regulation of angiogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis relationship: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis creation_date: 2016-10-12T14:19:41Z [Term] id: GO:1905555 name: positive regulation of blood vessel branching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie] synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie] is_a: GO:0045766 ! positive regulation of angiogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium is_a: GO:1905553 ! regulation of blood vessel branching intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis relationship: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis creation_date: 2016-10-12T14:19:49Z [Term] id: GO:1905557 name: regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly relationship: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly creation_date: 2016-10-14T13:14:57Z [Term] id: GO:1905558 name: negative regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly relationship: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly creation_date: 2016-10-14T13:15:08Z [Term] id: GO:1905559 name: positive regulation of mitotic nuclear envelope disassembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly relationship: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly creation_date: 2016-10-14T13:15:17Z [Term] id: GO:1905562 name: regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] is_a: GO:0001936 ! regulation of endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation relationship: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation creation_date: 2016-10-17T09:24:17Z [Term] id: GO:1905563 name: negative regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0001937 ! negative regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation relationship: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation creation_date: 2016-10-17T09:24:26Z [Term] id: GO:1905564 name: positive regulation of vascular endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0001938 ! positive regulation of endothelial cell proliferation is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation relationship: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation creation_date: 2016-10-17T09:24:35Z [Term] id: GO:1905606 name: regulation of presynapse assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] subset: goslim_synapse synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:0099174 ! regulation of presynapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0099054 ! regulates presynapse assembly relationship: RO:0002211 GO:0099054 ! regulates presynapse assembly creation_date: 2016-10-27T16:08:13Z [Term] id: GO:1905607 name: negative regulation of presynapse assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie] synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051964 ! negative regulation of synapse assembly is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly relationship: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly creation_date: 2016-10-27T16:08:20Z [Term] id: GO:1905608 name: positive regulation of presynapse assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie] synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie] synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie] synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie] synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905606 ! regulation of presynapse assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0099054 ! positively regulates presynapse assembly relationship: RO:0002213 GO:0099054 ! positively regulates presynapse assembly creation_date: 2016-10-27T16:08:28Z [Term] id: GO:1905627 name: regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process relationship: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process creation_date: 2016-10-31T14:26:20Z [Term] id: GO:1905628 name: negative regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie] synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process relationship: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process creation_date: 2016-10-31T14:26:28Z [Term] id: GO:1905629 name: positive regulation of serotonin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of serotonin formation" NARROW [GOC:TermGenie] synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:1905627 ! regulation of serotonin biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process relationship: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process creation_date: 2016-10-31T14:26:36Z [Term] id: GO:1905632 name: protein localization to euchromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] synonym: "protein localisation in euchromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to euchromatin" EXACT [GOC:TermGenie] synonym: "protein localization in euchromatin" EXACT [GOC:TermGenie] is_a: GO:0071168 ! protein localization to chromatin intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0000791 ! has target end location euchromatin relationship: RO:0002339 GO:0000791 ! has target end location euchromatin creation_date: 2016-11-01T16:16:14Z [Term] id: GO:1905633 name: establishment of protein localization to euchromatin namespace: biological_process def: "The directed movement of a protein to a specific location in an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] synonym: "establishment of protein localisation in euchromatin" EXACT [GOC:TermGenie] synonym: "establishment of protein localisation to euchromatin" EXACT [GOC:TermGenie] synonym: "establishment of protein localization in euchromatin" EXACT [GOC:TermGenie] is_a: GO:0071169 ! establishment of protein localization to chromatin is_a: GO:1905632 ! protein localization to euchromatin intersection_of: GO:0045184 ! establishment of protein localization intersection_of: RO:0002339 GO:0000791 ! has target end location euchromatin creation_date: 2016-11-01T16:16:22Z [Term] id: GO:1905634 name: regulation of protein localization to chromatin namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071168 ! regulates protein localization to chromatin relationship: RO:0002211 GO:0071168 ! regulates protein localization to chromatin creation_date: 2016-11-01T16:33:52Z [Term] id: GO:1905651 name: regulation of artery morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048844 ! regulates artery morphogenesis relationship: RO:0002211 GO:0048844 ! regulates artery morphogenesis creation_date: 2016-11-09T12:19:37Z [Term] id: GO:1905652 name: negative regulation of artery morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie] is_a: GO:1905651 ! regulation of artery morphogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis relationship: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis creation_date: 2016-11-09T12:19:53Z [Term] id: GO:1905653 name: positive regulation of artery morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie] synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie] synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1905651 ! regulation of artery morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis relationship: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis creation_date: 2016-11-09T12:20:01Z [Term] id: GO:1905671 name: regulation of lysosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0044088 ! regulation of vacuole organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007040 ! regulates lysosome organization relationship: RO:0002211 GO:0007040 ! regulates lysosome organization creation_date: 2016-11-11T22:01:04Z [Term] id: GO:1905672 name: negative regulation of lysosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "down regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "down regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "down regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "down-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "downregulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "downregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of lysosome organisation" NARROW [GOC:TermGenie] synonym: "inhibition of lysosome organization" NARROW [GOC:TermGenie] synonym: "inhibition of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:1905671 ! regulation of lysosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007040 ! negatively regulates lysosome organization relationship: RO:0002212 GO:0007040 ! negatively regulates lysosome organization creation_date: 2016-11-11T22:01:12Z [Term] id: GO:1905673 name: positive regulation of lysosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] synonym: "activation of lysosome organisation" NARROW [GOC:TermGenie] synonym: "activation of lysosome organization" NARROW [GOC:TermGenie] synonym: "activation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "positive regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "up regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "up regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "up-regulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "up-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] synonym: "upregulation of lysosome organisation" EXACT [GOC:TermGenie] synonym: "upregulation of lysosome organization" EXACT [GOC:TermGenie] synonym: "upregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0044090 ! positive regulation of vacuole organization is_a: GO:1905671 ! regulation of lysosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007040 ! positively regulates lysosome organization relationship: RO:0002213 GO:0007040 ! positively regulates lysosome organization creation_date: 2016-11-11T22:01:20Z [Term] id: GO:1905690 name: nucleus disassembly namespace: biological_process def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie] is_a: GO:0006997 ! nucleus organization is_a: GO:1903008 ! organelle disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: RO:0002590 GO:0005634 ! results in disassembly of nucleus relationship: RO:0002590 GO:0005634 ! results in disassembly of nucleus created_by: pr creation_date: 2016-11-14T13:38:57Z [Term] id: GO:1905720 name: cytoplasmic microtubule bundle namespace: cellular_component def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291] synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie] synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie] is_a: GO:0097427 ! microtubule bundle intersection_of: GO:0097427 ! microtubule bundle intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0005737 ! part of cytoplasm creation_date: 2016-11-24T16:52:02Z [Term] id: GO:1905755 name: protein localization to cytoplasmic microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule relationship: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule creation_date: 2016-12-12T15:31:07Z [Term] id: GO:1905770 name: regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation relationship: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation creation_date: 2016-12-21T12:44:13Z [Term] id: GO:1905771 name: negative regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation relationship: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation creation_date: 2016-12-21T12:44:23Z [Term] id: GO:1905772 name: positive regulation of mesodermal cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie] synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:1905770 ! regulation of mesodermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation relationship: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation creation_date: 2016-12-21T12:44:32Z [Term] id: GO:1905806 name: regulation of synapse pruning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] subset: goslim_synapse synonym: "regulation of synapse clearance" EXACT [] synonym: "regulation of synapse elimination" EXACT [] synonym: "regulation of synapse removal" EXACT [] is_a: GO:0050807 ! regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0098883 ! regulates synapse pruning relationship: RO:0002211 GO:0098883 ! regulates synapse pruning creation_date: 2017-01-11T22:03:15Z [Term] id: GO:1905807 name: negative regulation of synapse pruning namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] is_a: GO:1905806 ! regulation of synapse pruning is_a: GO:1905809 ! negative regulation of synapse organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0098883 ! negatively regulates synapse pruning relationship: RO:0002212 GO:0098883 ! negatively regulates synapse pruning creation_date: 2017-01-11T22:03:24Z [Term] id: GO:1905808 name: positive regulation of synapse pruning namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie] synonym: "regulation of synapse clearance" BROAD [] synonym: "regulation of synapse disassembly" BROAD [] synonym: "regulation of synapse elimination" BROAD [] synonym: "regulation of synapse removal" BROAD [] synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie] synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie] is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:1905806 ! regulation of synapse pruning intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0098883 ! positively regulates synapse pruning relationship: RO:0002213 GO:0098883 ! positively regulates synapse pruning creation_date: 2017-01-11T22:03:33Z [Term] id: GO:1905809 name: negative regulation of synapse organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] synonym: "down regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie] synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse development" EXACT [GOC:TermGenie] synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie] synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse development" NARROW [GOC:TermGenie] synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie] synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie] synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] is_a: GO:0050807 ! regulation of synapse organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0050808 ! negatively regulates synapse organization relationship: RO:0002212 GO:0050808 ! negatively regulates synapse organization creation_date: 2017-01-11T22:03:41Z [Term] id: GO:1905821 name: positive regulation of chromosome condensation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547] synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie] synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] is_a: GO:0060623 ! regulation of chromosome condensation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0030261 ! positively regulates chromosome condensation relationship: RO:0002213 GO:0030261 ! positively regulates chromosome condensation creation_date: 2017-01-13T14:13:44Z [Term] id: GO:1905833 name: negative regulation of microtubule nucleation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie] synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie] is_a: GO:0010968 ! regulation of microtubule nucleation is_a: GO:0031115 ! negative regulation of microtubule polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation relationship: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation creation_date: 2017-01-17T12:00:56Z [Term] id: GO:1905864 name: regulation of Atg1/ULK1 kinase complex assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] is_a: GO:0043254 ! regulation of protein-containing complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1904745 ! regulates Atg1/ULK1 kinase complex assembly relationship: RO:0002211 GO:1904745 ! regulates Atg1/ULK1 kinase complex assembly created_by: pr creation_date: 2017-01-26T13:23:26Z [Term] id: GO:1905871 name: regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge relationship: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge creation_date: 2017-01-27T19:34:55Z [Term] id: GO:1905872 name: negative regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge relationship: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge creation_date: 2017-01-27T19:35:04Z [Term] id: GO:1905873 name: positive regulation of protein localization to cell leading edge namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie] synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie] synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge relationship: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge creation_date: 2017-01-27T19:35:13Z [Term] id: GO:1905879 name: regulation of oogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0060284 ! regulation of cell development is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048477 ! regulates oogenesis relationship: RO:0002211 GO:0048477 ! regulates oogenesis creation_date: 2017-01-31T09:31:05Z [Term] id: GO:1905880 name: negative regulation of oogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down regulation of ovum development" EXACT [GOC:TermGenie] synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of ovum development" EXACT [GOC:TermGenie] synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie] synonym: "inhibition of ovum development" NARROW [GOC:TermGenie] synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048477 ! negatively regulates oogenesis relationship: RO:0002212 GO:0048477 ! negatively regulates oogenesis creation_date: 2017-01-31T09:31:15Z [Term] id: GO:1905881 name: positive regulation of oogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] synonym: "activation of oogenesis" NARROW [GOC:TermGenie] synonym: "activation of ovum development" NARROW [GOC:TermGenie] synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of ovum development" EXACT [GOC:TermGenie] synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie] synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of ovum development" EXACT [GOC:TermGenie] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905879 ! regulation of oogenesis is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048477 ! positively regulates oogenesis relationship: RO:0002213 GO:0048477 ! positively regulates oogenesis creation_date: 2017-01-31T09:31:23Z [Term] id: GO:1905899 name: regulation of smooth muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] is_a: GO:1901861 ! regulation of muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development relationship: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development creation_date: 2017-02-01T14:31:16Z [Term] id: GO:1905900 name: negative regulation of smooth muscle tissue development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie] is_a: GO:1901862 ! negative regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development relationship: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development creation_date: 2017-02-01T14:31:24Z [Term] id: GO:1905901 name: positive regulation of smooth muscle tissue development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie] synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] is_a: GO:1901863 ! positive regulation of muscle tissue development is_a: GO:1905899 ! regulation of smooth muscle tissue development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development relationship: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development creation_date: 2017-02-01T14:31:33Z [Term] id: GO:1905902 name: regulation of mesoderm formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001707 ! regulates mesoderm formation relationship: RO:0002211 GO:0001707 ! regulates mesoderm formation creation_date: 2017-02-03T12:28:20Z [Term] id: GO:1905903 name: negative regulation of mesoderm formation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000381 ! negative regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation relationship: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation creation_date: 2017-02-03T12:28:29Z [Term] id: GO:1905904 name: positive regulation of mesoderm formation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie] synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie] synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie] is_a: GO:1905902 ! regulation of mesoderm formation is_a: GO:2000382 ! positive regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001707 ! positively regulates mesoderm formation relationship: RO:0002213 GO:0001707 ! positively regulates mesoderm formation creation_date: 2017-02-03T12:28:38Z [Term] id: GO:1905921 name: regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process relationship: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process creation_date: 2017-02-08T13:08:30Z [Term] id: GO:1905922 name: negative regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process relationship: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process creation_date: 2017-02-08T13:08:39Z [Term] id: GO:1905923 name: positive regulation of acetylcholine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie] synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process relationship: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process creation_date: 2017-02-08T13:08:48Z [Term] id: GO:1905936 name: regulation of germ cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036093 ! regulates germ cell proliferation relationship: RO:0002211 GO:0036093 ! regulates germ cell proliferation creation_date: 2017-02-09T14:51:31Z [Term] id: GO:1905937 name: negative regulation of germ cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation relationship: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation creation_date: 2017-02-09T14:51:41Z [Term] id: GO:1905938 name: positive regulation of germ cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie] synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905936 ! regulation of germ cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation relationship: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation creation_date: 2017-02-09T14:51:51Z [Term] id: GO:1905939 name: regulation of gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0050793 ! regulation of developmental process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008406 ! regulates gonad development relationship: RO:0002211 GO:0008406 ! regulates gonad development creation_date: 2017-02-09T17:01:50Z [Term] id: GO:1905940 name: negative regulation of gonad development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "down regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of gonad development" EXACT [GOC:TermGenie] synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of gonad development" NARROW [GOC:TermGenie] synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie] synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000242 ! negative regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008406 ! negatively regulates gonad development relationship: RO:0002212 GO:0008406 ! negatively regulates gonad development creation_date: 2017-02-09T17:01:59Z [Term] id: GO:1905941 name: positive regulation of gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] synonym: "activation of gonad development" NARROW [GOC:TermGenie] synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie] synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie] synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of gonad development" EXACT [GOC:TermGenie] synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000243 ! positive regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008406 ! positively regulates gonad development relationship: RO:0002213 GO:0008406 ! positively regulates gonad development creation_date: 2017-02-09T17:02:08Z [Term] id: GO:1905952 name: regulation of lipid localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0032879 ! regulation of localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0010876 ! regulates lipid localization relationship: RO:0002211 GO:0010876 ! regulates lipid localization creation_date: 2017-02-21T12:12:22Z [Term] id: GO:1905953 name: negative regulation of lipid localization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie] synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie] synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie] synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0010876 ! negatively regulates lipid localization relationship: RO:0002212 GO:0010876 ! negatively regulates lipid localization creation_date: 2017-02-21T12:12:41Z [Term] id: GO:1905954 name: positive regulation of lipid localization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] synonym: "activation of lipid localisation" NARROW [GOC:TermGenie] synonym: "activation of lipid localization" NARROW [GOC:TermGenie] synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie] synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905952 ! regulation of lipid localization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0010876 ! positively regulates lipid localization relationship: RO:0002213 GO:0010876 ! positively regulates lipid localization creation_date: 2017-02-21T12:12:49Z [Term] id: GO:1905955 name: negative regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie] is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis relationship: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis creation_date: 2017-02-21T15:17:31Z [Term] id: GO:1905956 name: positive regulation of endothelial tube morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie] synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:1901509 ! regulation of endothelial tube morphogenesis is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis relationship: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis creation_date: 2017-02-21T15:17:39Z [Term] id: GO:1905962 name: glutamatergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron." [GO_REF:0000086, GOC:TermGenie, PMID:24030726] is_a: GO:0030182 ! neuron differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000679 ! results in acquisition of features of glutamatergic neuron relationship: RO:0002315 CL:0000679 ! results in acquisition of features of glutamatergic neuron creation_date: 2017-02-23T17:40:43Z [Term] id: GO:1990009 name: retinal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675] synonym: "induction of retinal programmed cell death" RELATED [] is_a: GO:0006915 ! apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0009004 ! occurs in retinal cell relationship: BFO:0000066 CL:0009004 ! occurs in retinal cell creation_date: 2012-12-12T10:15:08Z [Term] id: GO:1990010 name: compound eye retinal cell apoptotic process namespace: biological_process def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768] is_a: GO:1990009 ! retinal cell apoptotic process intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell relationship: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell creation_date: 2012-12-12T10:21:07Z [Term] id: GO:1990048 name: anterograde neuronal dense core vesicle transport namespace: biological_process def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451] subset: goslim_synapse synonym: "anterograde dense core granule trafficking" EXACT [] synonym: "anterograde dense core granule transport" EXACT [] is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099519 ! dense core granule cytoskeletal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle [Term] id: GO:1990049 name: retrograde neuronal dense core vesicle transport namespace: biological_process def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653] subset: goslim_synapse synonym: "retrograde dense core granule trafficking" EXACT [] synonym: "retrograde dense core granule transport" EXACT [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0047496 ! vesicle transport along microtubule is_a: GO:0099519 ! dense core granule cytoskeletal transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle creation_date: 2013-02-19T13:31:44Z [Term] id: GO:1990182 name: exosomal secretion namespace: biological_process def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898] synonym: "exosomal protein secretion" NARROW [PMID:18617898] synonym: "exosomal secretory pathway" EXACT [PMID:18617898] synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd] synonym: "multi-vesicular body fusion with plasma membrane" EXACT [] synonym: "secretion of exosome" EXACT [PMID:18617898] is_a: GO:0006887 ! exocytosis is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0006887 ! exocytosis intersection_of: RO:0004009 GO:0070062 ! has primary input extracellular exosome relationship: BFO:0000050 GO:0097734 ! part of extracellular exosome biogenesis relationship: RO:0004009 GO:0070062 ! has primary input extracellular exosome creation_date: 2013-09-04T21:08:14Z [Term] id: GO:1990188 name: euchromatin binding namespace: molecular_function def: "Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512] is_a: GO:0003682 ! chromatin binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 GO:0000791 ! has primary input euchromatin relationship: RO:0004009 GO:0000791 ! has primary input euchromatin creation_date: 2013-09-11T19:18:38Z [Term] id: GO:1990239 name: steroid hormone binding namespace: molecular_function def: "Binding to a steroid hormone." [GOC:ln] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding intersection_of: GO:0005488 ! binding intersection_of: RO:0004009 CHEBI:26764 ! has primary input relationship: RO:0004009 CHEBI:26764 ! has primary input creation_date: 2013-11-15T09:26:18Z [Term] id: GO:1990280 name: RNA localization to chromatin namespace: biological_process def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262] synonym: "RNA localisation to chromatin" EXACT [] is_a: GO:0006403 ! RNA localization intersection_of: GO:0006403 ! RNA localization intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin relationship: RO:0002339 GO:0000785 ! has target end location chromatin creation_date: 2014-01-30T15:55:34Z [Term] id: GO:1990351 name: transporter complex namespace: cellular_component def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex intersection_of: RO:0002215 GO:0005215 ! capable of transporter activity relationship: RO:0002215 GO:0005215 ! capable of transporter activity creation_date: 2014-03-26T14:23:27Z [Term] id: GO:1990497 name: regulation of cytoplasmic translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0002181 ! regulates cytoplasmic translation creation_date: 2014-09-26T11:11:29Z [Term] id: GO:1990502 name: dense core granule maturation namespace: biological_process def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674] synonym: "dense core vesicle maturation" EXACT [] is_a: GO:0061792 ! secretory granule maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 GO:0031045 ! results in maturation of dense core granule relationship: RO:0002299 GO:0031045 ! results in maturation of dense core granule creation_date: 2014-09-30T20:35:11Z [Term] id: GO:1990542 name: mitochondrial transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0055085 ! transmembrane transport intersection_of: GO:0046907 ! intracellular transport intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane creation_date: 2014-11-19T11:19:21Z [Term] id: GO:1990580 name: regulation of cytoplasmic translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975] is_a: GO:0006449 ! regulation of translational termination is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0050789 ! regulation of biological process intersection_of: RO:0002211 GO:0002184 ! regulates cytoplasmic translational termination relationship: RO:0002211 GO:0002184 ! regulates cytoplasmic translational termination creation_date: 2014-12-10T15:48:55Z [Term] id: GO:1990611 name: regulation of cytoplasmic translational initiation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445] is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:1904688 ! regulation of cytoplasmic translational initiation is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation creation_date: 2015-01-20T13:04:14Z [Term] id: GO:1990625 name: negative regulation of cytoplasmic translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress intersection_of: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation creation_date: 2015-01-31T21:25:56Z [Term] id: GO:1990751 name: Schwann cell chemotaxis namespace: biological_process def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995] is_a: GO:0036135 ! Schwann cell migration is_a: GO:0060326 ! cell chemotaxis intersection_of: GO:0006935 ! chemotaxis intersection_of: RO:0002565 CL:0002573 ! results in movement of Schwann cell creation_date: 2015-05-21T19:19:09Z [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0008104 ! intracellular protein localization intersection_of: GO:0008104 ! intracellular protein localization intersection_of: RO:0002339 GO:0071944 ! has target end location cell periphery relationship: RO:0002339 GO:0071944 ! has target end location cell periphery creation_date: 2015-06-18T22:37:39Z [Term] id: GO:1990849 name: vacuolar localization namespace: biological_process def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] synonym: "maintenance of vacuolar localization" EXACT [] synonym: "maintenance of vacuolar location" NARROW [] synonym: "maintenance of vacuole localization" EXACT [] synonym: "maintenance of vacuole location" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005773 ! has primary input vacuole relationship: RO:0004009 GO:0005773 ! has primary input vacuole created_by: mcc creation_date: 2015-09-10T08:16:02Z [Term] id: GO:1990863 name: acinar cell proliferation namespace: biological_process def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] synonym: "acinic cell proliferation" EXACT [] synonym: "acinous cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000622 ! acts on population of acinar cell relationship: RO:0012003 CL:0000622 ! acts on population of acinar cell creation_date: 2015-09-25T14:26:09Z [Term] id: GO:1990874 name: vascular associated smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] synonym: "vascular smooth muscle cell proliferation" EXACT [] synonym: "VSMC proliferation" EXACT [] is_a: GO:0048659 ! smooth muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell relationship: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell creation_date: 2015-09-29T16:34:59Z [Term] id: GO:1990904 name: ribonucleoprotein complex namespace: cellular_component alt_id: GO:0030529 alt_id: GO:1990903 def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] subset: goslim_pir synonym: "extracellular ribonucleoprotein complex" NARROW [] synonym: "intracellular ribonucleoprotein complex" NARROW [] synonym: "protein-RNA complex" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000051 CHEBI:33697 ! has part ribonucleic acid created_by: pr creation_date: 2015-11-19T12:26:37Z [Term] id: GO:1990917 name: ooplasm namespace: cellular_component def: "The cytoplasm of an ovum." [PMID:19022436] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 CL:0000025 ! part of egg cell relationship: BFO:0000050 CL:0000025 ! part of egg cell creation_date: 2015-12-10T21:40:16Z [Term] id: GO:2000026 name: regulation of multicellular organismal development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007275 ! regulates multicellular organism development relationship: RO:0002211 GO:0007275 ! regulates multicellular organism development creation_date: 2010-08-05T11:25:59Z [Term] id: GO:2000027 name: regulation of animal organ morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis relationship: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis creation_date: 2010-08-05T11:26:27Z [Term] id: GO:2000035 name: regulation of stem cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] synonym: "regulation of stem cell renewal" EXACT [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0017145 ! regulates stem cell division relationship: RO:0002211 GO:0017145 ! regulates stem cell division creation_date: 2010-08-05T11:34:53Z [Term] id: GO:2000068 name: regulation of defense response to insect namespace: biological_process def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002213 ! regulates defense response to insect relationship: RO:0002211 GO:0002213 ! regulates defense response to insect creation_date: 2010-08-23T09:30:00Z [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of leukocyte apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process relationship: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process creation_date: 2010-09-15T01:42:05Z [Term] id: GO:2000107 name: negative regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process relationship: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process creation_date: 2010-09-15T01:42:09Z [Term] id: GO:2000108 name: positive regulation of leukocyte apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of leukocyte apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process relationship: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process creation_date: 2010-09-15T01:42:12Z [Term] id: GO:2000109 name: regulation of macrophage apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "regulation of AICD" RELATED [GOC:yaf] synonym: "regulation of macrophage apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process relationship: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process creation_date: 2010-09-15T01:44:15Z [Term] id: GO:2000110 name: negative regulation of macrophage apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "negative regulation of AICD" RELATED [GOC:yaf] synonym: "negative regulation of macrophage apoptosis" NARROW [] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic process relationship: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic process creation_date: 2010-09-15T01:44:18Z [Term] id: GO:2000111 name: positive regulation of macrophage apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf] synonym: "positive regulation of AICD" RELATED [GOC:yaf] synonym: "positive regulation of macrophage apoptosis" NARROW [] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic process relationship: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic process creation_date: 2010-09-15T01:44:21Z [Term] id: GO:2000114 name: regulation of establishment of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] synonym: "regulation of cell polarization" EXACT [GOC:obol] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030010 ! regulates establishment of cell polarity relationship: RO:0002211 GO:0030010 ! regulates establishment of cell polarity creation_date: 2010-09-16T01:22:36Z [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis relationship: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis creation_date: 2010-09-29T12:43:53Z [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis relationship: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis creation_date: 2010-09-29T12:43:55Z [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis relationship: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis creation_date: 2010-09-29T12:43:57Z [Term] id: GO:2000145 name: regulation of cell motility namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] synonym: "regulation of cell locomotion" EXACT [GOC:obol] synonym: "regulation of cell movement" RELATED [GOC:obol] synonym: "regulation of movement of a cell" EXACT [GOC:obol] xref: Reactome:R-HSA-6785631 "ERBB2 Regulates Cell Motility" is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048870 ! regulates cell motility relationship: RO:0002211 GO:0048870 ! regulates cell motility creation_date: 2010-10-01T09:41:21Z [Term] id: GO:2000146 name: negative regulation of cell motility namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] synonym: "negative regulation of cell movement" RELATED [GOC:obol] synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048870 ! negatively regulates cell motility relationship: RO:0002212 GO:0048870 ! negatively regulates cell motility creation_date: 2010-10-01T09:41:26Z [Term] id: GO:2000147 name: positive regulation of cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] synonym: "positive regulation of cell movement" RELATED [GOC:obol] synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000145 ! regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048870 ! positively regulates cell motility relationship: RO:0002213 GO:0048870 ! positively regulates cell motility creation_date: 2010-10-01T09:41:30Z [Term] id: GO:2000155 name: positive regulation of cilium-dependent cell motility namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] synonym: "positive regulation of ciliary cell motility" RELATED [] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell motility relationship: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell motility creation_date: 2010-10-04T12:41:05Z [Term] id: GO:2000171 name: negative regulation of dendrite development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol] is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050773 ! regulation of dendrite development is_a: GO:0051093 ! negative regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0016358 ! negatively regulates dendrite development relationship: RO:0002212 GO:0016358 ! negatively regulates dendrite development creation_date: 2010-10-07T10:53:15Z [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve relationship: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve creation_date: 2010-10-07T12:07:54Z [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve relationship: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve creation_date: 2010-10-07T12:07:56Z [Term] id: GO:2000174 name: regulation of pro-T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation relationship: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation creation_date: 2010-10-11T10:24:30Z [Term] id: GO:2000175 name: negative regulation of pro-T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differentiation relationship: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differentiation creation_date: 2010-10-11T10:24:33Z [Term] id: GO:2000176 name: positive regulation of pro-T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002572 ! positively regulates pro-T cell differentiation relationship: RO:0002213 GO:0002572 ! positively regulates pro-T cell differentiation creation_date: 2010-10-11T10:24:35Z [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation relationship: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation creation_date: 2010-10-13T12:40:41Z [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation relationship: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation creation_date: 2010-10-13T12:40:43Z [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation relationship: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation creation_date: 2010-10-13T12:40:45Z [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis relationship: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis creation_date: 2010-10-13T12:46:31Z [Term] id: GO:2000194 name: regulation of female gonad development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "regulation of ovarian development" EXACT [GOC:obol] synonym: "regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008585 ! regulates female gonad development relationship: RO:0002211 GO:0008585 ! regulates female gonad development creation_date: 2010-10-19T10:45:34Z [Term] id: GO:2000195 name: negative regulation of female gonad development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "negative regulation of ovarian development" EXACT [GOC:obol] synonym: "negative regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008585 ! negatively regulates female gonad development relationship: RO:0002212 GO:0008585 ! negatively regulates female gonad development creation_date: 2010-10-19T10:45:38Z [Term] id: GO:2000196 name: positive regulation of female gonad development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] synonym: "positive regulation of ovarian development" EXACT [GOC:obol] synonym: "positive regulation of ovary development" EXACT [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008585 ! positively regulates female gonad development relationship: RO:0002213 GO:0008585 ! positively regulates female gonad development creation_date: 2010-10-19T10:45:41Z [Term] id: GO:2000211 name: regulation of glutamate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006536 ! regulates glutamate metabolic process relationship: RO:0002211 GO:0006536 ! regulates glutamate metabolic process creation_date: 2010-11-03T02:43:51Z [Term] id: GO:2000212 name: negative regulation of glutamate metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0006536 ! negatively regulates glutamate metabolic process relationship: RO:0002212 GO:0006536 ! negatively regulates glutamate metabolic process creation_date: 2010-11-03T02:43:55Z [Term] id: GO:2000213 name: positive regulation of glutamate metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl] synonym: "positive regulation of glutamate metabolism" EXACT [GOC:obol] synonym: "positive regulation of glutamic acid metabolic process" EXACT [GOC:obol] synonym: "positive regulation of glutamic acid metabolism" EXACT [GOC:obol] is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:2000211 ! regulation of glutamate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0006536 ! positively regulates glutamate metabolic process relationship: RO:0002213 GO:0006536 ! positively regulates glutamate metabolic process creation_date: 2010-11-03T02:43:59Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] subset: gocheck_do_not_annotate is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022414 ! regulates reproductive process relationship: RO:0002211 GO:0022414 ! regulates reproductive process created_by: mah creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000242 name: negative regulation of reproductive process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0022414 ! negatively regulates reproductive process relationship: RO:0002212 GO:0022414 ! negatively regulates reproductive process creation_date: 2010-11-10T02:44:05Z [Term] id: GO:2000243 name: positive regulation of reproductive process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0022414 ! positively regulates reproductive process relationship: RO:0002213 GO:0022414 ! positively regulates reproductive process creation_date: 2010-11-10T02:44:08Z [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0045769 ! negative regulation of asymmetric cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity relationship: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity creation_date: 2010-11-11T11:40:34Z [Term] id: GO:2000269 name: regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "regulation of fibroblast apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process relationship: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process creation_date: 2010-11-23T01:07:23Z [Term] id: GO:2000270 name: negative regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "negative regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process relationship: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process creation_date: 2010-11-23T01:07:27Z [Term] id: GO:2000271 name: positive regulation of fibroblast apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] synonym: "positive regulation of fibroblast apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process relationship: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process creation_date: 2010-11-23T01:07:29Z [Term] id: GO:2000272 name: negative regulation of signaling receptor activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol] subset: gocheck_obsoletion_candidate synonym: "negative regulation of receptor activity" BROAD [] synonym: "negative regulation of signalling receptor activity" EXACT [] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0044092 ! negative regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0038023 ! negatively regulates signaling receptor activity relationship: RO:0002212 GO:0038023 ! negatively regulates signaling receptor activity creation_date: 2010-12-02T09:28:47Z [Term] id: GO:2000278 name: regulation of DNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "regulation of DNA anabolism" EXACT [GOC:obol] synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of DNA formation" EXACT [GOC:obol] synonym: "regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process relationship: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process creation_date: 2010-12-08T04:48:15Z [Term] id: GO:2000279 name: negative regulation of DNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of DNA formation" EXACT [GOC:obol] synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic process relationship: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic process creation_date: 2010-12-08T04:48:20Z [Term] id: GO:2000282 name: regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] is_a: GO:0006521 ! regulation of amino acid metabolic process is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process relationship: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process created_by: vw creation_date: 2010-12-10T11:54:19Z [Term] id: GO:2000283 name: negative regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol] synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of amino acid formation" EXACT [GOC:obol] synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0045763 ! negative regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process relationship: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process creation_date: 2010-12-10T11:54:23Z [Term] id: GO:2000284 name: positive regulation of amino acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol] synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of amino acid formation" EXACT [GOC:obol] synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol] synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0045764 ! positive regulation of amino acid metabolic process is_a: GO:2000282 ! regulation of amino acid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process relationship: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process creation_date: 2010-12-10T11:54:27Z [Term] id: GO:2000287 name: positive regulation of myotome development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000290 ! regulation of myotome development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0061055 ! positively regulates myotome development relationship: RO:0002213 GO:0061055 ! positively regulates myotome development creation_date: 2010-12-16T05:17:15Z [Term] id: GO:2000288 name: positive regulation of myoblast proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation relationship: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation creation_date: 2010-12-16T05:20:52Z [Term] id: GO:2000290 name: regulation of myotome development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061055 ! regulates myotome development relationship: RO:0002211 GO:0061055 ! regulates myotome development creation_date: 2010-12-20T10:22:05Z [Term] id: GO:2000291 name: regulation of myoblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051450 ! regulates myoblast proliferation relationship: RO:0002211 GO:0051450 ! regulates myoblast proliferation creation_date: 2010-12-20T10:34:26Z [Term] id: GO:2000351 name: regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "regulation of endothelial cell apoptosis" NARROW [] synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process creation_date: 2011-02-03T10:43:16Z [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of endothelial cell apoptosis" NARROW [] synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process creation_date: 2011-02-03T10:43:20Z [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of endothelial cell apoptosis" NARROW [] synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process relationship: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process creation_date: 2011-02-03T10:43:23Z [Term] id: GO:2000374 name: regulation of oxygen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072592 ! regulates oxygen metabolic process relationship: RO:0002211 GO:0072592 ! regulates oxygen metabolic process creation_date: 2011-02-11T02:03:32Z [Term] id: GO:2000375 name: negative regulation of oxygen metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072592 ! negatively regulates oxygen metabolic process relationship: RO:0002212 GO:0072592 ! negatively regulates oxygen metabolic process creation_date: 2011-02-11T02:03:44Z [Term] id: GO:2000376 name: positive regulation of oxygen metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072592 ! positively regulates oxygen metabolic process relationship: RO:0002213 GO:0072592 ! positively regulates oxygen metabolic process creation_date: 2011-02-11T02:03:52Z [Term] id: GO:2000377 name: regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072593 ! regulates reactive oxygen species metabolic process relationship: RO:0002211 GO:0072593 ! regulates reactive oxygen species metabolic process created_by: mah creation_date: 2011-02-11T02:06:36Z [Term] id: GO:2000378 name: negative regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072593 ! negatively regulates reactive oxygen species metabolic process relationship: RO:0002212 GO:0072593 ! negatively regulates reactive oxygen species metabolic process creation_date: 2011-02-11T02:06:49Z [Term] id: GO:2000379 name: positive regulation of reactive oxygen species metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol] synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072593 ! positively regulates reactive oxygen species metabolic process relationship: RO:0002213 GO:0072593 ! positively regulates reactive oxygen species metabolic process creation_date: 2011-02-11T02:06:57Z [Term] id: GO:2000380 name: regulation of mesoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007498 ! regulates mesoderm development relationship: RO:0002211 GO:0007498 ! regulates mesoderm development creation_date: 2011-02-15T03:09:46Z [Term] id: GO:2000381 name: negative regulation of mesoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007498 ! negatively regulates mesoderm development relationship: RO:0002212 GO:0007498 ! negatively regulates mesoderm development creation_date: 2011-02-15T03:10:02Z [Term] id: GO:2000382 name: positive regulation of mesoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007498 ! positively regulates mesoderm development relationship: RO:0002213 GO:0007498 ! positively regulates mesoderm development creation_date: 2011-02-15T03:10:12Z [Term] id: GO:2000383 name: regulation of ectoderm development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007398 ! regulates ectoderm development relationship: RO:0002211 GO:0007398 ! regulates ectoderm development creation_date: 2011-02-15T03:17:10Z [Term] id: GO:2000384 name: negative regulation of ectoderm development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007398 ! negatively regulates ectoderm development relationship: RO:0002212 GO:0007398 ! negatively regulates ectoderm development creation_date: 2011-02-15T03:17:27Z [Term] id: GO:2000385 name: positive regulation of ectoderm development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007398 ! positively regulates ectoderm development relationship: RO:0002213 GO:0007398 ! positively regulates ectoderm development creation_date: 2011-02-15T03:17:39Z [Term] id: GO:2000401 name: regulation of lymphocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072676 ! regulates lymphocyte migration relationship: RO:0002211 GO:0072676 ! regulates lymphocyte migration creation_date: 2011-02-23T10:45:19Z [Term] id: GO:2000402 name: negative regulation of lymphocyte migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration relationship: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration creation_date: 2011-02-23T10:45:47Z [Term] id: GO:2000403 name: positive regulation of lymphocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration relationship: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration creation_date: 2011-02-23T10:46:06Z [Term] id: GO:2000404 name: regulation of T cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "regulation of T-cell migration" EXACT [GOC:obol] synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072678 ! regulates T cell migration relationship: RO:0002211 GO:0072678 ! regulates T cell migration creation_date: 2011-02-23T10:48:24Z [Term] id: GO:2000405 name: negative regulation of T cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "negative regulation of T-cell migration" EXACT [GOC:obol] synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072678 ! negatively regulates T cell migration relationship: RO:0002212 GO:0072678 ! negatively regulates T cell migration creation_date: 2011-02-23T10:48:52Z [Term] id: GO:2000406 name: positive regulation of T cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol] synonym: "positive regulation of T-cell migration" EXACT [GOC:obol] synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol] is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072678 ! positively regulates T cell migration relationship: RO:0002213 GO:0072678 ! positively regulates T cell migration creation_date: 2011-02-23T10:49:12Z [Term] id: GO:2000458 name: regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:1903975 ! regulation of glial cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035700 ! regulates astrocyte chemotaxis relationship: RO:0002211 GO:0035700 ! regulates astrocyte chemotaxis creation_date: 2011-03-04T10:53:50Z [Term] id: GO:2000459 name: negative regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:1903976 ! negative regulation of glial cell migration is_a: GO:2000458 ! regulation of astrocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035700 ! negatively regulates astrocyte chemotaxis relationship: RO:0002212 GO:0035700 ! negatively regulates astrocyte chemotaxis creation_date: 2011-03-04T10:54:28Z [Term] id: GO:2000464 name: positive regulation of astrocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:1903977 ! positive regulation of glial cell migration is_a: GO:2000458 ! regulation of astrocyte chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035700 ! positively regulates astrocyte chemotaxis relationship: RO:0002213 GO:0035700 ! positively regulates astrocyte chemotaxis creation_date: 2011-03-04T04:43:29Z [Term] id: GO:2000471 name: regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration relationship: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration creation_date: 2011-03-09T09:34:08Z [Term] id: GO:2000472 name: negative regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem cell migration relationship: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem cell migration creation_date: 2011-03-09T09:34:54Z [Term] id: GO:2000473 name: positive regulation of hematopoietic stem cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem cell migration relationship: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem cell migration creation_date: 2011-03-09T09:35:25Z [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis creation_date: 2011-03-18T02:18:34Z [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis creation_date: 2011-03-18T02:19:22Z [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis relationship: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis creation_date: 2011-03-18T02:19:54Z [Term] id: GO:2000508 name: regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis relationship: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis creation_date: 2011-03-22T10:21:38Z [Term] id: GO:2000509 name: negative regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemotaxis relationship: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemotaxis creation_date: 2011-03-22T10:21:45Z [Term] id: GO:2000510 name: positive regulation of dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemotaxis relationship: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemotaxis creation_date: 2011-03-22T10:21:49Z [Term] id: GO:2000527 name: regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis relationship: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis creation_date: 2011-03-23T12:18:32Z [Term] id: GO:2000528 name: negative regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cell chemotaxis relationship: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cell chemotaxis creation_date: 2011-03-23T12:18:39Z [Term] id: GO:2000529 name: positive regulation of myeloid dendritic cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cell chemotaxis relationship: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cell chemotaxis creation_date: 2011-03-23T12:18:45Z [Term] id: GO:2000542 name: negative regulation of gastrulation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0007369 ! negatively regulates gastrulation relationship: RO:0002212 GO:0007369 ! negatively regulates gastrulation creation_date: 2011-04-01T04:10:08Z [Term] id: GO:2000543 name: positive regulation of gastrulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0007369 ! positively regulates gastrulation relationship: RO:0002213 GO:0007369 ! positively regulates gastrulation creation_date: 2011-04-01T04:10:15Z [Term] id: GO:2000547 name: regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly relationship: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly creation_date: 2011-04-03T07:21:55Z [Term] id: GO:2000548 name: negative regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "negative regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendrite assembly relationship: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendrite assembly creation_date: 2011-04-03T07:22:01Z [Term] id: GO:2000549 name: positive regulation of dendritic cell dendrite assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] synonym: "positive regulation of dendritic extension" RELATED [GOC:obol] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendrite assembly relationship: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendrite assembly creation_date: 2011-04-03T07:22:06Z [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of DNA formation" EXACT [GOC:obol] synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic process relationship: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic process creation_date: 2011-04-04T10:01:20Z [Term] id: GO:2000647 name: negative regulation of stem cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation relationship: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation creation_date: 2011-04-27T01:04:22Z [Term] id: GO:2000648 name: positive regulation of stem cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation relationship: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation creation_date: 2011-04-27T01:04:25Z [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process relationship: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process creation_date: 2011-05-09T07:34:16Z [Term] id: GO:2000669 name: negative regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apoptotic process relationship: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apoptotic process creation_date: 2011-05-09T07:34:21Z [Term] id: GO:2000670 name: positive regulation of dendritic cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of dendritic cell apoptosis" NARROW [] is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097048 ! positively regulates dendritic cell apoptotic process relationship: RO:0002213 GO:0097048 ! positively regulates dendritic cell apoptotic process creation_date: 2011-05-09T07:34:26Z [Term] id: GO:2000671 name: regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process relationship: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process creation_date: 2011-05-09T10:56:17Z [Term] id: GO:2000672 name: negative regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "negative regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process relationship: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process creation_date: 2011-05-09T10:56:21Z [Term] id: GO:2000673 name: positive regulation of motor neuron apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol] synonym: "positive regulation of motor neuron apoptosis" NARROW [] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process relationship: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process creation_date: 2011-05-09T10:56:24Z [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation relationship: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation creation_date: 2011-05-25T09:08:01Z [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045662 ! negative regulation of myoblast differentiation is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation relationship: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation creation_date: 2011-05-25T09:08:06Z [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol] synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] is_a: GO:0045663 ! positive regulation of myoblast differentiation is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation relationship: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation creation_date: 2011-05-25T09:08:09Z [Term] id: GO:2000725 name: regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation relationship: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation creation_date: 2011-06-08T10:51:06Z [Term] id: GO:2000726 name: negative regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation relationship: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation creation_date: 2011-06-08T10:51:11Z [Term] id: GO:2000727 name: positive regulation of cardiac muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol] synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation relationship: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation creation_date: 2011-06-08T10:51:15Z [Term] id: GO:2000736 name: regulation of stem cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048863 ! regulates stem cell differentiation relationship: RO:0002211 GO:0048863 ! regulates stem cell differentiation creation_date: 2011-06-14T02:05:16Z [Term] id: GO:2000737 name: negative regulation of stem cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation relationship: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation creation_date: 2011-06-14T02:05:20Z [Term] id: GO:2000738 name: positive regulation of stem cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation relationship: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation creation_date: 2011-06-14T02:05:23Z [Term] id: GO:2000765 name: regulation of cytoplasmic translation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002181 ! regulates cytoplasmic translation relationship: RO:0002211 GO:0002181 ! regulates cytoplasmic translation creation_date: 2011-06-20T10:39:19Z [Term] id: GO:2000766 name: negative regulation of cytoplasmic translation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0017148 ! negative regulation of translation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0002181 ! negatively regulates cytoplasmic translation relationship: RO:0002212 GO:0002181 ! negatively regulates cytoplasmic translation creation_date: 2011-06-20T10:39:23Z [Term] id: GO:2000767 name: positive regulation of cytoplasmic translation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] is_a: GO:0045727 ! positive regulation of translation is_a: GO:2000765 ! regulation of cytoplasmic translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0002181 ! positively regulates cytoplasmic translation relationship: RO:0002213 GO:0002181 ! positively regulates cytoplasmic translation creation_date: 2011-06-20T10:39:26Z [Term] id: GO:2000785 name: regulation of autophagosome assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF] synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol] synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol] synonym: "regulation of autophagosome formation" EXACT [GOC:obol] synonym: "regulation of PAS formation" RELATED [GOC:obol] is_a: GO:0044088 ! regulation of vacuole organization is_a: GO:1902115 ! regulation of organelle assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0000045 ! regulates autophagosome assembly relationship: RO:0002211 GO:0000045 ! regulates autophagosome assembly created_by: rl creation_date: 2011-06-24T11:19:08Z [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development creation_date: 2011-06-24T01:53:50Z [Term] id: GO:2000791 name: negative regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development creation_date: 2011-06-24T01:53:53Z [Term] id: GO:2000792 name: positive regulation of mesenchymal cell proliferation involved in lung development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development relationship: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development creation_date: 2011-06-24T01:53:56Z [Term] id: GO:2000794 name: regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis creation_date: 2011-06-25T07:22:38Z [Term] id: GO:2000795 name: negative regulation of epithelial cell proliferation involved in lung morphogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis relationship: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis creation_date: 2011-06-25T07:22:42Z [Term] id: GO:2000810 name: regulation of bicellular tight junction assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF] synonym: "regulation of tight junction formation" EXACT [GOC:obol] xref: Reactome:R-HSA-8935964 "RUNX1 regulates expression of components of tight junctions" is_a: GO:1901888 ! regulation of cell junction assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0070830 ! regulates bicellular tight junction assembly relationship: RO:0002211 GO:0070830 ! regulates bicellular tight junction assembly creation_date: 2011-07-06T01:08:28Z [Term] id: GO:2000818 name: negative regulation of myoblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation relationship: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation creation_date: 2011-07-12T03:06:04Z [Term] id: GO:2000826 name: regulation of heart morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003007 ! regulates heart morphogenesis relationship: RO:0002211 GO:0003007 ! regulates heart morphogenesis creation_date: 2011-07-19T10:08:58Z [Term] id: GO:2000831 name: regulation of steroid hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035929 ! regulates steroid hormone secretion relationship: RO:0002211 GO:0035929 ! regulates steroid hormone secretion creation_date: 2011-07-26T08:38:46Z [Term] id: GO:2000832 name: negative regulation of steroid hormone secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion relationship: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion creation_date: 2011-07-26T08:38:50Z [Term] id: GO:2000833 name: positive regulation of steroid hormone secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion relationship: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion creation_date: 2011-07-26T08:38:51Z [Term] id: GO:2000834 name: regulation of androgen secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035935 ! regulates androgen secretion relationship: RO:0002211 GO:0035935 ! regulates androgen secretion creation_date: 2011-07-26T08:39:45Z [Term] id: GO:2000835 name: negative regulation of androgen secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035935 ! negatively regulates androgen secretion relationship: RO:0002212 GO:0035935 ! negatively regulates androgen secretion creation_date: 2011-07-26T08:39:48Z [Term] id: GO:2000836 name: positive regulation of androgen secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035935 ! positively regulates androgen secretion relationship: RO:0002213 GO:0035935 ! positively regulates androgen secretion creation_date: 2011-07-26T08:39:51Z [Term] id: GO:2000977 name: regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045664 ! regulation of neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0021879 ! regulates forebrain neuron differentiation relationship: RO:0002211 GO:0021879 ! regulates forebrain neuron differentiation creation_date: 2011-08-03T12:09:12Z [Term] id: GO:2000978 name: negative regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:2000977 ! regulation of forebrain neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0021879 ! negatively regulates forebrain neuron differentiation relationship: RO:0002212 GO:0021879 ! negatively regulates forebrain neuron differentiation creation_date: 2011-08-03T12:09:16Z [Term] id: GO:2000979 name: positive regulation of forebrain neuron differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:2000977 ! regulation of forebrain neuron differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0021879 ! positively regulates forebrain neuron differentiation relationship: RO:0002213 GO:0021879 ! positively regulates forebrain neuron differentiation creation_date: 2011-08-03T12:09:19Z [Term] id: GO:2001014 name: regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation relationship: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation creation_date: 2011-08-11T08:54:37Z [Term] id: GO:2001015 name: negative regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation relationship: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation creation_date: 2011-08-11T08:54:41Z [Term] id: GO:2001016 name: positive regulation of skeletal muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation relationship: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation creation_date: 2011-08-11T08:54:44Z [Term] id: GO:2001017 name: regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008090 ! regulates retrograde axonal transport relationship: RO:0002211 GO:0008090 ! regulates retrograde axonal transport creation_date: 2011-08-11T09:44:42Z [Term] id: GO:2001018 name: negative regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0008090 ! negatively regulates retrograde axonal transport relationship: RO:0002212 GO:0008090 ! negatively regulates retrograde axonal transport creation_date: 2011-08-11T09:44:46Z [Term] id: GO:2001019 name: positive regulation of retrograde axon cargo transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol] is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:2001017 ! regulation of retrograde axon cargo transport intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008090 ! positively regulates retrograde axonal transport relationship: RO:0002213 GO:0008090 ! positively regulates retrograde axonal transport creation_date: 2011-08-11T09:44:49Z [Term] id: GO:2001026 name: regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis relationship: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis creation_date: 2011-08-22T01:07:26Z [Term] id: GO:2001027 name: negative regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chemotaxis relationship: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chemotaxis creation_date: 2011-08-22T01:07:31Z [Term] id: GO:2001028 name: positive regulation of endothelial cell chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035767 ! positively regulates endothelial cell chemotaxis relationship: RO:0002213 GO:0035767 ! positively regulates endothelial cell chemotaxis creation_date: 2011-08-22T01:07:34Z [Term] id: GO:2001035 name: regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035981 ! regulates tongue muscle cell differentiation relationship: RO:0002211 GO:0035981 ! regulates tongue muscle cell differentiation creation_date: 2011-08-24T11:10:16Z [Term] id: GO:2001036 name: negative regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902810 ! negative regulation of skeletal muscle fiber differentiation is_a: GO:2001035 ! regulation of tongue muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035981 ! negatively regulates tongue muscle cell differentiation relationship: RO:0002212 GO:0035981 ! negatively regulates tongue muscle cell differentiation creation_date: 2011-08-24T11:10:20Z [Term] id: GO:2001037 name: positive regulation of tongue muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] is_a: GO:1902811 ! positive regulation of skeletal muscle fiber differentiation is_a: GO:2001035 ! regulation of tongue muscle cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035981 ! positively regulates tongue muscle cell differentiation relationship: RO:0002213 GO:0035981 ! positively regulates tongue muscle cell differentiation creation_date: 2011-08-24T11:10:22Z [Term] id: GO:2001049 name: regulation of tendon cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035990 ! regulates tendon cell differentiation relationship: RO:0002211 GO:0035990 ! regulates tendon cell differentiation creation_date: 2011-09-01T09:20:32Z [Term] id: GO:2001050 name: negative regulation of tendon cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "negative regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "negative regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001049 ! regulation of tendon cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0035990 ! negatively regulates tendon cell differentiation relationship: RO:0002212 GO:0035990 ! negatively regulates tendon cell differentiation creation_date: 2011-09-01T09:20:38Z [Term] id: GO:2001051 name: positive regulation of tendon cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation." [GOC:obol] synonym: "positive regulation of muscle attachment cell differentiation" EXACT [GOC:obol] synonym: "positive regulation of tenocyte differentiation" RELATED [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001049 ! regulation of tendon cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035990 ! positively regulates tendon cell differentiation relationship: RO:0002213 GO:0035990 ! positively regulates tendon cell differentiation creation_date: 2011-09-01T09:20:42Z [Term] id: GO:2001053 name: regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process relationship: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process creation_date: 2011-09-08T02:49:59Z [Term] id: GO:2001054 name: negative regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "negative regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apoptotic process relationship: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apoptotic process creation_date: 2011-09-08T02:50:05Z [Term] id: GO:2001055 name: positive regulation of mesenchymal cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] synonym: "positive regulation of mesenchymal cell apoptosis" NARROW [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apoptotic process relationship: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apoptotic process creation_date: 2011-09-08T02:50:09Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process relationship: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process created_by: dph creation_date: 2011-10-17T11:36:25Z [Term] id: GO:2001198 name: regulation of dendritic cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation relationship: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation creation_date: 2011-11-04T02:01:27Z [Term] id: GO:2001199 name: negative regulation of dendritic cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902106 ! negative regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097028 ! negatively regulates dendritic cell differentiation relationship: RO:0002212 GO:0097028 ! negatively regulates dendritic cell differentiation creation_date: 2011-11-04T02:01:33Z [Term] id: GO:2001200 name: positive regulation of dendritic cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902107 ! positive regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097028 ! positively regulates dendritic cell differentiation relationship: RO:0002213 GO:0097028 ! positively regulates dendritic cell differentiation creation_date: 2011-11-04T02:01:36Z [Term] id: GO:2001204 name: regulation of osteoclast development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036035 ! regulates osteoclast development relationship: RO:0002211 GO:0036035 ! regulates osteoclast development creation_date: 2011-11-10T10:58:59Z [Term] id: GO:2001205 name: negative regulation of osteoclast development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "negative regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0045671 ! negative regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0036035 ! negatively regulates osteoclast development relationship: RO:0002212 GO:0036035 ! negatively regulates osteoclast development creation_date: 2011-11-10T10:59:06Z [Term] id: GO:2001206 name: positive regulation of osteoclast development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol] synonym: "positive regulation of osteoclast cell development" EXACT [GOC:obol] is_a: GO:0045672 ! positive regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0036035 ! positively regulates osteoclast development relationship: RO:0002213 GO:0036035 ! positively regulates osteoclast development creation_date: 2011-11-10T10:59:12Z [Term] id: GO:2001212 name: regulation of vasculogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001570 ! regulates vasculogenesis relationship: RO:0002211 GO:0001570 ! regulates vasculogenesis creation_date: 2011-11-15T01:22:31Z [Term] id: GO:2001213 name: negative regulation of vasculogenesis namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis relationship: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis creation_date: 2011-11-15T01:22:36Z [Term] id: GO:2001214 name: positive regulation of vasculogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001570 ! positively regulates vasculogenesis relationship: RO:0002213 GO:0001570 ! positively regulates vasculogenesis creation_date: 2011-11-15T01:22:39Z [Term] id: GO:2001222 name: regulation of neuron migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "regulation of neuron guidance" RELATED [GOC:obol] synonym: "regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001764 ! regulates neuron migration relationship: RO:0002211 GO:0001764 ! regulates neuron migration creation_date: 2011-11-17T10:01:38Z [Term] id: GO:2001223 name: negative regulation of neuron migration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "negative regulation of neuron guidance" RELATED [GOC:obol] synonym: "negative regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0001764 ! negatively regulates neuron migration relationship: RO:0002212 GO:0001764 ! negatively regulates neuron migration creation_date: 2011-11-17T10:01:45Z [Term] id: GO:2001224 name: positive regulation of neuron migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol] synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol] synonym: "positive regulation of neuron guidance" RELATED [GOC:obol] synonym: "positive regulation of neuronal migration" EXACT [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0001764 ! positively regulates neuron migration relationship: RO:0002213 GO:0001764 ! positively regulates neuron migration creation_date: 2011-11-17T10:01:49Z [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway relationship: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway creation_date: 2011-11-24T01:20:49Z [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling pathway relationship: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling pathway creation_date: 2011-11-24T01:20:54Z [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling pathway relationship: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling pathway creation_date: 2011-11-24T01:20:58Z [Term] id: GO:2001251 name: negative regulation of chromosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002212 GO:0051276 ! negatively regulates chromosome organization relationship: RO:0002212 GO:0051276 ! negatively regulates chromosome organization creation_date: 2011-12-02T02:01:20Z [Term] id: GO:2001252 name: positive regulation of chromosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0051276 ! positively regulates chromosome organization relationship: RO:0002213 GO:0051276 ! positively regulates chromosome organization creation_date: 2011-12-02T02:01:26Z [Term] id: IAO:0000027 name: data item is_a: IAO:0000030 ! information content entity [Term] id: IAO:0000030 name: information content entity is_a: BFO:0000031 ! generically dependent continuant [Term] id: IAO:0000078 name: curation status specification def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part [Term] id: IAO:0000102 name: data about an ontology part def: "Data about an ontology part is a data item about a part of an ontology, for example a term" [] is_a: IAO:0000027 ! data item [Term] id: IAO:0000225 name: obsolescence reason specification def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] is_a: IAO:0000102 ! data about an ontology part [Term] id: IAO:0000409 name: denotator type def: "A denotator type indicates how a term should be interpreted from an ontological perspective." [] is_a: IAO:0000102 ! data about an ontology part [Term] id: IDO:0000450 name: pathogenic disposition def: "A disposition to initiate processes that result in a disorder." [] comment: A pathogenic disposition is realized in processes that create a disorder. is_a: BFO:0000016 ! disposition relationship: RO:0000052 BFO:0000040 ! characteristic of material entity [Term] id: IDO:0000528 name: pathogen def: "A material entity with a pathogenic disposition." [] is_a: BFO:0000040 ! material entity intersection_of: BFO:0000040 ! material entity intersection_of: RO:0000091 IDO:0000450 ! has disposition pathogenic disposition relationship: RO:0000091 IDO:0000450 ! has disposition pathogenic disposition [Term] id: IDO:0000626 name: appearance of disorder def: "A process by which a disorder comes into existence." [] is_a: GO:0008150 ! biological_process relationship: RO:0002297 OGMS:0000045 ! results in formation of disorder [Term] id: MBA:1009 name: fiber tracts synonym: "fiber tracts" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1009 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1009 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1009 is_a: MBA:ENTITY is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0000122 ! neuron projection bundle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain [Term] id: MBA:1065 name: Hindbrain synonym: "HB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1065 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1065 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1065 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002028 ! hindbrain intersection_of: UBERON:0002028 ! hindbrain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:343 ! part of Brain stem [Term] id: MBA:10671 name: Median eminence synonym: "ME" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=10671 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=10671 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=10671 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002197 ! median eminence of neurohypophysis intersection_of: UBERON:0002197 ! median eminence of neurohypophysis intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus [Term] id: MBA:108 name: choroid plexus synonym: "chpl" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=108 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=108 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=108 is_a: MBA:ENTITY is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0002307 ! choroid plexus of lateral ventricle intersection_of: UBERON:0001886 ! choroid plexus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:81 ! part of lateral ventricle [Term] id: MBA:1097 name: Hypothalamus synonym: "HY" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1097 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1097 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1097 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001898 ! hypothalamus intersection_of: UBERON:0001898 ! hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1129 ! part of Interbrain [Term] id: MBA:1117 name: Pons, behavioral state related synonym: "P-sat" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1117 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1117 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1117 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:771 ! part of Pons [Term] id: MBA:1129 name: Interbrain synonym: "IB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1129 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1129 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1129 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001894 ! diencephalon intersection_of: UBERON:0001894 ! diencephalon intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:343 ! part of Brain stem [Term] id: MBA:1132 name: Pons, sensory related synonym: "P-sen" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1132 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1132 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1132 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:771 ! part of Pons [Term] id: MBA:1143 name: Cerebellar cortex, granular layer synonym: "CBXgr" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1143 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1143 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1143 is_a: MBA:ENTITY is_a: UBERON:0002956 ! granular layer of cerebellar cortex intersection_of: UBERON:0002956 ! granular layer of cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex [Term] id: MBA:1144 name: Cerebellar cortex, molecular layer synonym: "CBXmo" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1144 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1144 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1144 is_a: MBA:ENTITY is_a: UBERON:0002974 ! molecular layer of cerebellar cortex intersection_of: UBERON:0002974 ! molecular layer of cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex [Term] id: MBA:1145 name: Cerebellar cortex, Purkinje layer synonym: "CBXpu" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=1145 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=1145 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=1145 is_a: MBA:ENTITY is_a: UBERON:0002979 ! Purkinje cell layer of cerebellar cortex intersection_of: UBERON:0002979 ! Purkinje cell layer of cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:528 ! part of Cerebellar cortex [Term] id: MBA:129 name: third ventricle synonym: "V3" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=129 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=129 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=129 is_a: MBA:ENTITY is_a: UBERON:0002286 ! third ventricle intersection_of: UBERON:0002286 ! third ventricle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems [Term] id: MBA:141 name: Periventricular region synonym: "PVR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=141 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=141 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=141 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus [Term] id: MBA:145 name: fourth ventricle synonym: "V4" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=145 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=145 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=145 is_a: MBA:ENTITY is_a: UBERON:0002422 ! fourth ventricle intersection_of: UBERON:0002422 ! fourth ventricle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems [Term] id: MBA:147 name: Locus ceruleus synonym: "LC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=147 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=147 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=147 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002148 ! locus ceruleus intersection_of: UBERON:0002148 ! locus ceruleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1117 ! part of Pons, behavioral state related [Term] id: MBA:157 name: Periventricular zone synonym: "PVZ" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=157 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=157 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=157 is_a: MBA:ENTITY is_a: UBERON:0002271 ! periventricular zone of hypothalamus intersection_of: UBERON:0002271 ! periventricular zone of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1097 ! part of Hypothalamus [Term] id: MBA:164 name: central canal, spinal cord/medulla synonym: "c" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=164 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=164 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=164 is_a: MBA:ENTITY is_a: UBERON:0002291 ! central canal of spinal cord intersection_of: UBERON:0002291 ! central canal of spinal cord intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems [Term] id: MBA:223 name: Arcuate hypothalamic nucleus synonym: "ARH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=223 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=223 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=223 is_a: MBA:ENTITY is_a: UBERON:0001932 ! arcuate nucleus of hypothalamus is_a: UBERON:0006331 ! brainstem nucleus intersection_of: UBERON:0001932 ! arcuate nucleus of hypothalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:157 ! part of Periventricular zone [Term] id: MBA:238 name: Nucleus raphe pontis synonym: "RPO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=238 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=238 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=238 is_a: MBA:ENTITY is_a: UBERON:0002047 ! pontine raphe nucleus intersection_of: UBERON:0002047 ! pontine raphe nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1117 ! part of Pons, behavioral state related [Term] id: MBA:304325711 name: retina synonym: "retina" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=304325711 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=304325711 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=304325711 is_a: MBA:ENTITY is_a: UBERON:0000966 ! retina intersection_of: UBERON:0000966 ! retina intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain [Term] id: MBA:313 name: Midbrain synonym: "MB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=313 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=313 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=313 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001891 ! midbrain intersection_of: UBERON:0001891 ! midbrain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:343 ! part of Brain stem [Term] id: MBA:338 name: Subfornical organ synonym: "SFO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=338 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=338 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=338 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002219 ! subfornical organ intersection_of: UBERON:0002219 ! subfornical organ intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:141 ! part of Periventricular region [Term] id: MBA:339 name: Midbrain, sensory related synonym: "MBsen" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=339 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=339 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=339 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:313 ! part of Midbrain [Term] id: MBA:343 name: Brain stem synonym: "BS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=343 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=343 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=343 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002298 ! brainstem intersection_of: UBERON:0002298 ! brainstem intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:8 ! part of Basic cell groups and regions [Term] id: MBA:354 name: Medulla synonym: "MY" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=354 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=354 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=354 is_a: MBA:ENTITY is_a: UBERON:0001896 ! medulla oblongata intersection_of: UBERON:0001896 ! medulla oblongata intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1065 ! part of Hindbrain [Term] id: MBA:370 name: Medulla, motor related synonym: "MY-mot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=370 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=370 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=370 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:354 ! part of Medulla [Term] id: MBA:398 name: Superior olivary complex synonym: "SOC" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=398 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=398 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=398 is_a: MBA:ENTITY is_a: UBERON:0002128 ! superior olivary complex intersection_of: UBERON:0002128 ! superior olivary complex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1132 ! part of Pons, sensory related [Term] id: MBA:462 name: Superior salivatory nucleus synonym: "SSN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=462 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=462 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=462 is_a: MBA:ENTITY is_a: UBERON:0002149 ! superior salivatory nucleus intersection_of: UBERON:0002149 ! superior salivatory nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:987 ! part of Pons, motor related [Term] id: MBA:477 name: Striatum synonym: "STR" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=477 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=477 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=477 is_a: MBA:ENTITY is_a: UBERON:0002435 ! striatum intersection_of: UBERON:0002435 ! striatum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:623 ! part of Cerebral nuclei [Term] id: MBA:512 name: Cerebellum synonym: "CB" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=512 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=512 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=512 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002037 ! cerebellum intersection_of: UBERON:0002037 ! cerebellum intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:8 ! part of Basic cell groups and regions [Term] id: MBA:528 name: Cerebellar cortex synonym: "CBX" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=528 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=528 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=528 is_a: MBA:ENTITY is_a: UBERON:0002129 ! cerebellar cortex intersection_of: UBERON:0002129 ! cerebellar cortex intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:512 ! part of Cerebellum [Term] id: MBA:549 name: Thalamus synonym: "TH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=549 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=549 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=549 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001897 ! dorsal plus ventral thalamus intersection_of: UBERON:0001897 ! dorsal plus ventral thalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1129 ! part of Interbrain [Term] id: MBA:567 name: Cerebrum synonym: "CH" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=567 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=567 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=567 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001893 ! telencephalon intersection_of: UBERON:0001893 ! telencephalon intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:8 ! part of Basic cell groups and regions [Term] id: MBA:599626923 name: Subcommissural organ synonym: "SCO" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=599626923 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=599626923 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=599626923 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0002139 ! subcommissural organ intersection_of: UBERON:0002139 ! subcommissural organ intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:339 ! part of Midbrain, sensory related [Term] id: MBA:623 name: Cerebral nuclei synonym: "CNU" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=623 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=623 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=623 is_a: MBA:ENTITY is_a: UBERON:8440012 ! cerebral nuclei intersection_of: UBERON:8440012 ! cerebral nuclei intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:567 ! part of Cerebrum [Term] id: MBA:73 name: ventricular systems synonym: "VS" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=73 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=73 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=73 is_a: MBA:ENTITY is_a: UBERON:0005281 ! ventricular system of central nervous system intersection_of: UBERON:0005281 ! ventricular system of central nervous system intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain [Term] id: MBA:771 name: Pons synonym: "P" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=771 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=771 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=771 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0000988 ! pons intersection_of: UBERON:0000988 ! pons intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:1065 ! part of Hindbrain [Term] id: MBA:773 name: Hypoglossal nucleus synonym: "XII" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=773 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=773 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=773 is_a: MBA:ENTITY is_a: UBERON:0002871 ! hypoglossal nucleus intersection_of: UBERON:0002871 ! hypoglossal nucleus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:370 ! part of Medulla, motor related [Term] id: MBA:8 name: Basic cell groups and regions synonym: "grey" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=8 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=8 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=8 is_a: MBA:ENTITY is_a: UBERON:0002616 ! regional part of brain intersection_of: UBERON:0002616 ! regional part of brain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:997 ! part of brain [Term] id: MBA:81 name: lateral ventricle synonym: "VL" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=81 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=81 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=81 is_a: MBA:ENTITY is_a: UBERON:0002285 ! telencephalic ventricle intersection_of: UBERON:0002285 ! telencephalic ventricle intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:73 ! part of ventricular systems [Term] id: MBA:856 name: Thalamus, polymodal association cortex related synonym: "DORpm" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=856 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=856 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=856 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:549 ! part of Thalamus [Term] id: MBA:953 name: Pineal body synonym: "PIN" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=953 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=953 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=953 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001905 ! pineal body intersection_of: UBERON:0001905 ! pineal body intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:958 ! part of Epithalamus [Term] id: MBA:958 name: Epithalamus synonym: "EPI" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=958 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=958 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=958 is_a: MBA:8 ! Basic cell groups and regions is_a: UBERON:0001899 ! epithalamus intersection_of: UBERON:0001899 ! epithalamus intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 MBA:856 ! part of Thalamus, polymodal association cortex related [Term] id: MBA:987 name: Pons, motor related synonym: "P-mot" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=987 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=987 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=987 is_a: BFO:0000004 ! independent continuant relationship: BFO:0000050 MBA:771 ! part of Pons [Term] id: MBA:997 name: brain synonym: "root" EXACT [] xref: http://atlas.brain-map.org/atlas?atlas=1#structure=997 xref: http://atlas.brain-map.org/atlas?atlas=2#structure=997 xref: http://atlas.brain-map.org/atlas?atlas=602630314#structure=997 is_a: MBA:ENTITY is_a: UBERON:0008823 ! neural tube derived brain intersection_of: UBERON:0000955 ! brain intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus [Term] id: MBA:ENTITY is_a: UBERON:0001062 ! anatomical entity intersection_of: UBERON:0001062 ! anatomical entity intersection_of: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus relationship: BFO:0000050 NCBITaxon:10090 ! part of Mus musculus [Term] id: NCBITaxon:1 name: root namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:30365038 xref: PMID:32761142 is_a: OBI:0100026 [Term] id: NCBITaxon:10066 name: Muridae namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15371245 is_a: NCBITaxon:337687 ! Muroidea [Term] id: NCBITaxon:10088 name: Mus namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:39107 ! Murinae [Term] id: NCBITaxon:10090 name: Mus musculus namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:862507 ! Mus [Term] id: NCBITaxon:117570 name: Teleostomi namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:117571 name: Euteleostomi namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi [Term] id: NCBITaxon:1206794 name: Ecdysozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:131567 name: cellular organisms namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1 ! root [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:1437010 name: Boreoeutheria namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11743200 xref: PMID:11791233 is_a: NCBITaxon:9347 ! Eutheria [Term] id: NCBITaxon:186623 name: Actinopteri namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7898 ! Actinopterygii [Term] id: NCBITaxon:1963758 name: Myomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:9989 ! Rodentia [Term] id: NCBITaxon:197562 name: Pancrustacea namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:10874751 xref: PMID:11557979 is_a: NCBITaxon:197563 ! Mandibulata [Term] id: NCBITaxon:197563 name: Mandibulata namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11557979 xref: PMID:9727836 is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:2759 name: Eukaryota namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:314146 name: Euarchontoglires namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11214319 xref: PMID:12082125 xref: PMID:12878460 xref: PMID:15522813 is_a: NCBITaxon:1437010 ! Boreoeutheria [Term] id: NCBITaxon:314147 name: Glires namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11214319 xref: PMID:12082125 xref: PMID:15522813 is_a: NCBITaxon:314146 ! Euarchontoglires [Term] id: NCBITaxon:32443 name: Teleostei namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32523 name: Tetrapoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] id: NCBITaxon:32524 name: Amniota namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda [Term] id: NCBITaxon:32525 name: Theria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia [Term] id: NCBITaxon:33154 name: Opisthokonta namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:33208 name: Metazoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33154 ! Opisthokonta disjoint_from: NCBITaxon:4751 ! Fungi [Term] id: NCBITaxon:33213 name: Bilateria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:33317 name: Protostomia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria disjoint_from: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:33511 name: Deuterostomia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:337687 name: Muroidea namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15019624 xref: PMID:15371245 is_a: NCBITaxon:1963758 ! Myomorpha [Term] id: NCBITaxon:39107 name: Murinae namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:10066 ! Muridae [Term] id: NCBITaxon:40674 name: Mammalia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:41665 name: Neopterygii namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:186623 ! Actinopteri [Term] id: NCBITaxon:4751 name: Fungi namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:11062127 xref: PMID:12684019 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:50557 name: Insecta namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:6072 name: Eumetazoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa [Term] id: NCBITaxon:6656 name: Arthropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6960 name: Hexapoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:7711 name: Chordata namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:7742 name: Vertebrata namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata [Term] id: NCBITaxon:7776 name: Gnathostomata namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata [Term] id: NCBITaxon:7898 name: Actinopterygii namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi disjoint_from: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:8287 name: Sarcopterygii namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:862507 name: Mus namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:10088 ! Mus [Term] id: NCBITaxon:88770 name: Panarthropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:89593 name: Craniata namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata [Term] id: NCBITaxon:9347 name: Eutheria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:32525 ! Theria [Term] id: NCBITaxon:9989 name: Rodentia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:314147 ! Glires [Term] id: OGMS:0000045 name: disorder def: "A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease." [] is_a: BFO:0000040 ! material entity [Term] id: PATO:0000001 name: quality namespace: quality alt_id: PATO:0000072 def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] is_a: BFO:0000020 ! specifically dependent continuant [Term] id: PATO:0000025 name: composition namespace: quality def: "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." [PATOC:GVG] comment: For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood). subset: attribute_slim subset: scalar_slim synonym: "composed of" EXACT [] synonym: "compositionality" EXACT [] synonym: "content" EXACT [] synonym: "structure, composition" EXACT [] is_a: PATO:0000141 ! structure [Term] id: PATO:0000033 name: concentration of namespace: quality def: "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." [Wikipedia:http\://en.wikipedia.org/wiki/concentration] subset: attribute_slim subset: relational_slim subset: scalar_slim synonym: "concentration" EXACT [] is_a: PATO:0000070 ! amount [Term] id: PATO:0000051 name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0000052 name: shape namespace: quality alt_id: PATO:0001647 def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG] comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. subset: attribute_slim synonym: "relational shape quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000057 name: occurrence namespace: quality alt_id: PATO:0000156 alt_id: PATO:0000158 def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence." [PATOC:GVG] subset: attribute_slim subset: hpo_slim synonym: "incidence" EXACT [] synonym: "temporal" BROAD [] is_a: PATO:0002323 ! temporal distribution quality [Term] id: PATO:0000068 name: qualitative namespace: quality def: "A quality of an entity that is descriptive or observational, typically not represented numerically." [https://libguides.macalester.edu/c.php?g=527786&p=3608639, https://www.ncbi.nlm.nih.gov/books/NBK470395/] comment: TODO: define this or obsolete it and move children somewhere else. is_a: PATO:0000001 ! quality [Term] id: PATO:0000069 name: deviation (from_normal) namespace: quality def: "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000070 name: amount namespace: quality alt_id: PATO:0000053 alt_id: PATO:0000071 alt_id: PATO:0001169 alt_id: PATO:0001226 def: "The number of entities of this type that are part of the whole organism." [PATOC:GVG] comment: This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10. subset: attribute_slim synonym: "count in organism" RELATED [] synonym: "number" RELATED [] synonym: "presence" RELATED [] synonym: "presence or absence in organism" EXACT [] synonym: "quantitative" EXACT [] is_a: PATO:0103000 ! quantitative relationship: RO:0015012 PATO:0001555 ! reciprocal of has number of [Term] id: PATO:0000085 name: sensitivity toward namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim synonym: "sensitivity" EXACT [] is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000117 name: size namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." [WordNet:WordNet] subset: attribute_slim subset: scalar_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000122 name: length namespace: quality def: "A 1-D extent quality which is equal to the distance between two points." [PATOC:GVG] comment: Length often refers to the longer or longest dimension of an object, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion. subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent [Term] id: PATO:0000136 name: closure namespace: quality def: "A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent." [PATOC:CJM, PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000141 name: structure namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." [PATOC:GVG] subset: attribute_slim synonym: "conformation" BROAD [VT:1000738] synonym: "relational structural quality" EXACT [] is_a: PATO:0000051 ! morphology [Term] id: PATO:0000150 name: texture namespace: quality def: "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology [Term] id: PATO:0000161 name: rate namespace: quality def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time." [PATOC:melissa] subset: attribute_slim subset: scalar_slim is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0000169 name: viability namespace: quality def: "An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0000297 name: arrested namespace: quality alt_id: PATO:0001508 def: "A quality of a process which ends earlier than the natural end time or reference process." [PATOC:LC] comment: TODO: the definition is incorrect. See absent. subset: value_slim synonym: "abolished" EXACT [] synonym: "incomplete" RELATED [] is_a: PATO:0002052 ! decreased occurrence is_a: PATO:0002324 ! offset quality [Term] id: PATO:0000402 name: branched namespace: quality def: "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." [WordNet:WordNet] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ramified" EXACT [] synonym: "ramiform" EXACT [] is_a: PATO:0002009 ! branchiness [Term] id: PATO:0000407 name: flat namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature." [web:http\://www.merriam-webster.com/] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "plate-like" RELATED [] is_a: PATO:0002254 ! flattened [Term] id: PATO:0000411 name: circular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." [thefreedictionary.com:thefreedictionary.com] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "round" RELATED [] synonym: "rounded" RELATED [] is_a: PATO:0000947 ! elliptic [Term] id: PATO:0000460 name: abnormal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "aberrant" RELATED [] synonym: "atypia" RELATED [] synonym: "atypical" RELATED [] synonym: "defective" RELATED [] is_a: PATO:0000069 ! deviation (from_normal) [Term] id: PATO:0000461 name: normal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "average" RELATED [] is_a: PATO:0000068 ! qualitative [Term] id: PATO:0000462 name: absent namespace: quality alt_id: PATO:0001996 def: "A quality denoting the lack of an entity." [thefreedictionary.:thefreedictionary.] comment: We recommend using the new absent terms (physical absence, absent anatomical entity, or absent process) instead of this class. This is a legacy term and will ultimately be obsoleted.\nSee https://github.com/pato-ontology/pato/issues/331. subset: absent_slim subset: mpath_slim subset: value_slim synonym: "absence" EXACT [] synonym: "absent from organism" EXACT [] is_a: PATO:0000070 ! amount disjoint_from: PATO:0000467 ! present relationship: RO:0015012 PATO:0001558 ! reciprocal of lacking processual parts relationship: RO:0015012 PATO:0002000 ! reciprocal of lacks all parts of type [Term] id: PATO:0000467 name: present namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's existence." [PATOC:GVG] subset: absent_slim subset: value_slim synonym: "present in organism" RELATED [] is_a: PATO:0000070 ! amount [Term] id: PATO:0000470 name: increased amount namespace: quality alt_id: PATO:0000420 alt_id: PATO:0000650 def: "An amount which is relatively high." [PATOC:GVG] subset: value_slim synonym: "accessory" RELATED [] synonym: "increased" RELATED [] synonym: "increased number" EXACT [] synonym: "present in greater numbers in organism" EXACT [] synonym: "supernumerary" EXACT [] is_a: PATO:0000467 ! present is_a: PATO:0002300 ! increased quality intersection_of: PATO:0000070 ! amount intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0000498 name: increased duration namespace: quality alt_id: PATO:0000715 def: "A duration quality of a process which is relatively high." [PATOC:GVG] subset: value_slim synonym: "chronic" RELATED [] synonym: "high time" EXACT [] synonym: "increased period" EXACT [] synonym: "increased time" EXACT [] synonym: "prolonged period" RELATED [] synonym: "slow time" RELATED [] is_a: PATO:0001309 ! duration is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001309 ! duration intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0000499 name: decreased duration namespace: quality alt_id: PATO:0000716 def: "A duration quality of a process which is relatively low." [PATOC:GVG] subset: value_slim synonym: "decreased period" EXACT [] synonym: "decreased time" EXACT [] synonym: "fast time" RELATED [] synonym: "low period" EXACT [] synonym: "shortened period" EXACT [] is_a: PATO:0001309 ! duration is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001309 ! duration intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0000502 name: delayed namespace: quality def: "A quality of a process which starts later than the natural start time or the reference process." [PATOC:LC] subset: value_slim synonym: "late" RELATED [] is_a: PATO:0002325 ! onset quality [Term] id: PATO:0000516 name: sensitive toward namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "sensitive" EXACT [] is_a: PATO:0000085 ! sensitivity toward [Term] id: PATO:0000573 name: increased length namespace: quality def: "A length quality which is relatively large." [PATOC:GVG] subset: value_slim synonym: "long" EXACT [] is_a: PATO:0000122 ! length is_a: PATO:0000586 ! increased size intersection_of: PATO:0000122 ! length intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0000574 name: decreased length namespace: quality def: "A length quality which is relatively small." [PATOC:GVG] subset: value_slim synonym: "short" EXACT [] synonym: "shortened" RELATED [] synonym: "stubby" RELATED [] is_a: PATO:0000122 ! length is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000122 ! length intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0000586 name: increased size namespace: quality alt_id: PATO:0001202 def: "A size quality which is relatively high." [PATOC:GVG] subset: value_slim synonym: "big" RELATED [] synonym: "enlarged" RELATED [] synonym: "expanded" RELATED [] synonym: "great" RELATED [] synonym: "large" RELATED [] is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0000587 name: decreased size namespace: quality def: "A size quality which is relatively low." [PATOC:GVG] subset: value_slim synonym: "hypoplasia" NARROW [] synonym: "reduced" RELATED [] synonym: "small" RELATED [] synonym: "tiny" RELATED [] synonym: "underdeveloped" NARROW [] is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0000608 name: closed namespace: quality def: "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." [answers.com:answers.com] subset: value_slim synonym: "blocked" RELATED [] is_a: PATO:0000136 ! closure [Term] id: PATO:0000694 name: premature namespace: quality alt_id: PATO:0000691 alt_id: PATO:0002086 def: "A quality of a process which starts earlier than the natural start time or the reference process." [PATO:LC] subset: value_slim synonym: "advanced" EXACT [] synonym: "early" RELATED [] synonym: "precocious" RELATED [] is_a: PATO:0002325 ! onset quality [Term] id: PATO:0000718 name: lethal (sensu genetics) namespace: quality def: "A viability quality inhering in a population by virtue of the bearer's long term survival inability." [PATOC:GVG] subset: disposition_slim subset: value_slim is_a: PATO:0000169 ! viability [Term] id: PATO:0000911 name: decreased rate namespace: quality def: "A rate which is relatively low." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "slow rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000161 ! rate intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0000912 name: increased rate namespace: quality def: "A rate which is relatively high." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "fast rate" EXACT [] synonym: "high rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000161 ! rate intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0000947 name: elliptic namespace: quality def: "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ellipse-shaped" EXACT [] synonym: "ellipsoid" EXACT [] synonym: "elliptical" EXACT [] synonym: "oval" RELATED [] synonym: "ovoid" RELATED [] is_a: PATO:0002318 ! superelliptic [Term] id: PATO:0000957 name: opacity namespace: quality def: "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001300 ! optical quality [Term] id: PATO:0000963 name: opaque namespace: quality def: "A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "clouding" RELATED [] synonym: "cloudy" RELATED [] synonym: "non-transparent" EXACT [] is_a: PATO:0000957 ! opacity [Term] id: PATO:0000964 name: transparent namespace: quality def: "A optical quality inhering in a bearer by virtue of the bearer's lacking opacity." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "clear" EXACT [] synonym: "hyaline" EXACT [] is_a: PATO:0000957 ! opacity [Term] id: PATO:0001018 name: physical quality namespace: quality def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG] subset: attribute_slim synonym: "relational physical quality" EXACT [] xref: Wikipedia:Physical_property is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001031 name: elasticity namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001046 name: resistance to namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim subset: scalar_slim synonym: "resistance" EXACT [] is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0001159 name: concentrated namespace: quality def: "A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0000033 ! concentration of [Term] id: PATO:0001162 name: increased concentration namespace: quality def: "A concentration which is higher relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "high concentration" EXACT [] is_a: PATO:0000470 ! increased amount is_a: PATO:0001159 ! concentrated is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001163 name: decreased concentration namespace: quality def: "A concentration which is lower relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "low concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0001997 ! decreased amount is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001171 name: elastic namespace: quality def: "An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0001031 ! elasticity [Term] id: PATO:0001178 name: resistant to namespace: quality def: "A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "resistant" EXACT [] is_a: PATO:0001046 ! resistance to [Term] id: PATO:0001236 name: process quality namespace: quality alt_id: PATO:0001239 alt_id: PATO:0001240 def: "A quality which inheres in an process." [PATOC:GVG] comment: See comments of relational quality of a physical entity. synonym: "quality of a process" EXACT [] synonym: "quality of occurrent" EXACT [] synonym: "quality of process" EXACT [] synonym: "relational quality of occurrent" EXACT [] is_a: PATO:0000001 ! quality disjoint_from: PATO:0001241 ! physical object quality [Term] id: PATO:0001241 name: physical object quality namespace: quality alt_id: PATO:0001237 alt_id: PATO:0001238 def: "A quality which inheres in a continuant." [PATOC:GVG] comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. synonym: "monadic quality of a continuant" EXACT [] synonym: "monadic quality of an object" NARROW [] synonym: "monadic quality of continuant" NARROW [] synonym: "multiply inhering quality of a physical entity" EXACT [] synonym: "quality of a continuant" EXACT [] synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality is_a: PATO:0000001 ! quality [Term] id: PATO:0001300 name: optical quality namespace: quality def: "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0070060 ! quality of interaction of a substance with electromagnetic radiation [Term] id: PATO:0001309 name: duration namespace: quality alt_id: PATO:0000081 def: "A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point." [PATOC:mellybelly] subset: attribute_slim subset: hpo_slim synonym: "period" EXACT [] synonym: "time" RELATED [] is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0001374 name: ploidy namespace: quality def: "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." [Wikipedia:http\://en.wikipedia.org/wiki/Ploidy] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001375 name: haploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Haploid] subset: cell_quality subset: value_slim is_a: PATO:0001393 ! euploid [Term] id: PATO:0001393 name: euploid namespace: quality def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Euploid] subset: cell_quality subset: value_slim is_a: PATO:0001374 ! ploidy [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0001397 name: cellular potency namespace: quality def: "A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001400 name: unipotent namespace: quality def: "A cellular potency that is the capacity to produce only one differentiated cell type." [Wikipedia:http\://en.wikipedia.org/wiki/Unipotent] comment: Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells. subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001401 name: oligopotent namespace: quality def: "A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity." [PATOC:MAH] comment: Less potent than multipotent, often thought of as precursor or progenitor cell status. subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001402 name: multipotent namespace: quality def: "A cellular potency that is the capacity to form multiple differentiated cell types." [Wikipedia:http\://en.wikipedia.org/wiki/Multipotent] subset: cell_quality subset: disposition_slim subset: value_slim is_a: PATO:0001397 ! cellular potency [Term] id: PATO:0001404 name: nucleate quality namespace: quality def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0001405 name: anucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality [Term] id: PATO:0001407 name: mononucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001410 name: striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001457 name: sensitivity of a process namespace: quality def: "A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim synonym: "sensitivity of occurrent" EXACT [] is_a: PATO:0002062 ! physical quality of a process [Term] id: PATO:0001547 name: quality of a gas namespace: quality def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/gasdefinition.htm, PATOC:GVG] subset: attribute_slim synonym: "gaseous" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001548 name: quality of a liquid namespace: quality def: "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." [url:http\://www.chemistry-dictionary.com/definition/liquid.php] subset: attribute_slim synonym: "liquidity" EXACT [] is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0001549 name: increased sensitivity toward namespace: quality def: "A sensitivity toward an external stimulus which is higher than normal/average." [PATO:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "high sensitivity toward" EXACT [] synonym: "increased sensitivity" EXACT [] is_a: PATO:0000516 ! sensitive toward is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000516 ! sensitive toward intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001550 name: decreased sensitivity toward namespace: quality def: "A sensitivity toward an external stimulus which is lower than normal/average." [PATO:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "decreased sensitivity" EXACT [] synonym: "low sensitivity toward" EXACT [] is_a: PATO:0000516 ! sensitive toward is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000516 ! sensitive toward intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001551 name: increased sensitivity of a process namespace: quality def: "A sensitivity of a process which is higher than normal or average." [PATO:GVG] subset: relational_slim subset: value_slim synonym: "high sensitivity of occurrent" EXACT [] synonym: "increased sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001552 name: decreased sensitivity of a process namespace: quality def: "A sensitivity of a process which is lower than normal or average." [PATO:GVG] subset: relational_slim subset: value_slim synonym: "decreased sensitivity of occurrent" EXACT [] synonym: "low sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001555 name: has number of namespace: quality def: "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." [PATOC:CJM] subset: attribute_slim subset: relational_slim synonym: "cardinality" RELATED [] synonym: "extra or missing physical or functional parts" EXACT [] synonym: "has or lacks parts of type" EXACT [] synonym: "mereological quality" EXACT [] synonym: "number" RELATED [] synonym: "number of" EXACT [] xref: OBO_REL:has_part is_a: PATO:0000070 ! amount [Term] id: PATO:0001558 name: lacking processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0001564 ! extra or missing processual parts relationship: RO:0015012 PATO:0000462 ! reciprocal of absent [Term] id: PATO:0001564 name: extra or missing processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's processual parts." [PATOC:GVG] subset: relational_slim is_a: PATO:0001236 ! process quality [Term] id: PATO:0001579 name: contractility namespace: quality def: "A physical quality that is the ability to contract or shrink." [WordNet:WordNet] subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality [Term] id: PATO:0001580 name: increased contractility namespace: quality def: "A contractility which is relatively high." [PATO:GVG] subset: disposition_slim subset: value_slim synonym: "high contractility" EXACT [] is_a: PATO:0001690 ! contractile is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001690 ! contractile intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001581 name: decreased contractility namespace: quality def: "A contractility which is relatively low." [PATO:GVG] subset: disposition_slim subset: value_slim synonym: "low contractility" EXACT [] is_a: PATO:0001690 ! contractile is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001690 ! contractile intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001591 name: curvature namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." [WordNet:WordNet] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0001650 name: increased resistance to namespace: quality def: "A resistance to a stimulus which is relatively high." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "high resistance to" EXACT [] synonym: "increased resistance" EXACT [] is_a: PATO:0001178 ! resistant to is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001178 ! resistant to intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001651 name: decreased resistance to namespace: quality def: "A resistance to a stimulus which is relatively low." [PATOC:GVG] subset: disposition_slim subset: relational_slim subset: value_slim synonym: "decreased resistance" EXACT [] synonym: "low resistance to" EXACT [] is_a: PATO:0001178 ! resistant to is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001178 ! resistant to intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001690 name: contractile namespace: quality def: "A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted." [PATOC:GVG] comment: This refers to the disposition of the bearer. subset: disposition_slim subset: value_slim is_a: PATO:0001579 ! contractility [Term] id: PATO:0001708 name: 1-D extent namespace: quality def: "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." [PATOC:GVG] subset: attribute_slim synonym: "1-D size" EXACT [] is_a: PATO:0000117 ! size [Term] id: PATO:0001748 name: invaginated namespace: quality def: "A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001857 ! concave [Term] id: PATO:0001857 name: concave namespace: quality def: "A shape quality in a bearer by virtue of the bearer's curving inward." [WordNet:WordNet] subset: cell_quality subset: value_slim is_a: PATO:0002005 ! concavity [Term] id: PATO:0001873 name: cylindrical namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section." [PATOC:MAH] subset: cell_quality subset: value_slim synonym: "rod-like" EXACT [] synonym: "rod-shaped" EXACT [] synonym: "tubulate" NARROW [] is_a: PATO:0002007 ! convex 3-D shape relationship: RO:0015011 PATO:0000411 ! has cross section circular [Term] id: PATO:0001905 name: has normal numbers of parts of type namespace: quality def: "The bearer of this quality has_part = n, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] subset: relational_slim synonym: "having physical part" EXACT [] is_a: PATO:0001555 ! has number of relationship: RO:0015012 PATO:0002050 ! reciprocal of normal amount [Term] id: PATO:0001908 name: multinucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated [Term] id: PATO:0001987 name: saccular namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." [PATOC:MAH] subset: value_slim synonym: "sacular" EXACT [] is_a: PATO:0002014 ! structure, cavities [Term] id: PATO:0001992 name: cellularity namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0001993 name: multicellular namespace: quality def: "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." [PATOC:GVG] subset: value_slim is_a: PATO:0001992 ! cellularity [Term] id: PATO:0001995 name: organismal quality namespace: quality def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM] is_a: PATO:0001241 ! physical object quality [Term] id: PATO:0001997 name: decreased amount namespace: quality alt_id: PATO:0000419 alt_id: PATO:0000468 def: "An amount which is relatively low." [PATOC:GVG] subset: value_slim synonym: "decreased" RELATED [] synonym: "decreased number" EXACT [] synonym: "present in fewer numbers in organism" EXACT [] synonym: "reduced" RELATED [] synonym: "subnumerary" RELATED [] is_a: PATO:0000467 ! present is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0000070 ! amount intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001999 name: lacks parts or has fewer parts of type namespace: quality def: "The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type." [PATOC:CJM] subset: relational_slim synonym: "loss of" EXACT [] is_a: PATO:0002083 ! altered number of [Term] id: PATO:0002000 name: lacks all parts of type namespace: quality alt_id: PATO:0001557 def: "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." [PATOC:CJM] comment: Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2. subset: relational_slim synonym: "lacks all physical parts of type" EXACT [] xref: OBO_REL:lacks_part is_a: PATO:0001999 ! lacks parts or has fewer parts of type relationship: RO:0015012 PATO:0000462 ! reciprocal of absent [Term] id: PATO:0002001 name: has fewer parts of type namespace: quality alt_id: PATO:0001569 def: "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly." [PATOC:CJM] comment: Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type. subset: relational_slim synonym: "decreased number of" EXACT [] synonym: "has decreased number of" EXACT [] synonym: "has fewer physical parts of type" EXACT [] is_a: PATO:0001997 ! decreased amount is_a: PATO:0001999 ! lacks parts or has fewer parts of type is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001999 ! lacks parts or has fewer parts of type intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0002002 name: has extra parts of type namespace: quality alt_id: PATO:0001560 def: "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] comment: In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q= E2=finger. subset: relational_slim synonym: "has extra parts of" EXACT [] synonym: "has increased number of" EXACT [] synonym: "having extra physical parts" EXACT [] synonym: "having supernumerary physical parts" EXACT [] synonym: "increased number of" EXACT [] is_a: PATO:0000470 ! increased amount is_a: PATO:0002083 ! altered number of is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002083 ! altered number of intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0002005 name: concavity namespace: quality def: "Surface shape that refers to the inward or outward curvature of the surface." [PATOC:MAH] subset: attribute_slim is_a: PATO:0000052 ! shape [Term] id: PATO:0002006 name: 2-D shape namespace: quality def: "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." [PATOC:CJM] subset: attribute_slim synonym: "2-D projection" RELATED [] synonym: "cross-sectional" RELATED [] is_a: PATO:0000052 ! shape [Term] id: PATO:0002007 name: convex 3-D shape namespace: quality def: "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." [PATOC:CJM] comment: Use this term or an is_a child of this term when the entire shape of the object is known. subset: attribute_slim xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png is_a: PATO:0002266 ! 3-D shape relationship: RO:0015011 PATO:0002006 ! has cross section 2-D shape [Term] id: PATO:0002009 name: branchiness namespace: quality def: "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." [PATOC:MAH] subset: attribute_slim subset: cell_quality is_a: PATO:0000052 ! shape [Term] id: PATO:0002014 name: structure, cavities namespace: quality def: "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0002039 name: biconcave namespace: quality def: "A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces." [PATOC:GVG] subset: value_slim is_a: PATO:0001857 ! concave [Term] id: PATO:0002045 name: dendritic namespace: quality def: "A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure." [PATOC:cvs] subset: value_slim synonym: "dendriform" EXACT [] synonym: "dendroid" EXACT [] synonym: "dendroidal" EXACT [] is_a: PATO:0000402 ! branched creation_date: 2009-02-15T08:11:41Z [Term] id: PATO:0002050 name: normal amount namespace: quality def: "An amount which normal." [PATOC:GVG] synonym: "present in normal numbers in organism" EXACT [] is_a: PATO:0000467 ! present relationship: RO:0015012 PATO:0001905 ! reciprocal of has normal numbers of parts of type creation_date: 2009-03-20T11:16:22Z [Term] id: PATO:0002051 name: increased occurrence namespace: quality def: "An occurrence which is relatively high." [PATOC:GVG] synonym: "increased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal creation_date: 2009-03-26T11:10:11Z [Term] id: PATO:0002052 name: decreased occurrence namespace: quality def: "An occurrence which is relatively low." [PATOC:GVG] synonym: "decreased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal creation_date: 2009-03-26T11:12:35Z [Term] id: PATO:0002062 name: physical quality of a process namespace: quality subset: attribute_slim is_a: PATO:0001236 ! process quality creation_date: 2009-06-05T09:16:46Z [Term] id: PATO:0002064 name: fenestrated namespace: quality def: "A structure quality inhering in a bearer by virtue of the bearer's delimited by a surface with holes." [PATOC:me] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure creation_date: 2009-07-01T01:46:53Z [Term] id: PATO:0002078 name: hollow namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." [url:http\://www.merriam-webster.com/dictionary/hollow] subset: value_slim is_a: PATO:0002014 ! structure, cavities creation_date: 2009-09-18T02:19:20Z [Term] id: PATO:0002083 name: altered number of namespace: quality def: "Having extra or fewer parts." [PATOC:GVG] subset: attribute_slim subset: relational_slim is_a: PATO:0000051 ! morphology is_a: PATO:0001555 ! has number of creation_date: 2009-09-21T10:41:58Z [Term] id: PATO:0002094 name: basophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0070045 ! anatomical histological quality creation_date: 2009-10-05T12:05:23Z [Term] id: PATO:0002124 name: laminar namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure creation_date: 2009-10-06T04:37:14Z [Term] id: PATO:0002146 name: virulence namespace: quality def: "A quality inhering in a bearer by virtue of the severity of infectious disease caused by the bearer in a target organism." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0001-8941-3984] subset: attribute_slim subset: scalar_slim is_a: PATO:0001995 ! organismal quality creation_date: 2009-10-30T05:04:06Z [Term] id: PATO:0002147 name: reduced virulence namespace: quality def: "A virulence that is relatively low." [PATOC:GVG] subset: value_slim synonym: "attenuated" EXACT [] is_a: PATO:0002146 ! virulence is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0002146 ! virulence intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal creation_date: 2009-10-30T05:05:02Z [Term] id: PATO:0002148 name: increased virulence namespace: quality def: "A virulence that is relatively high." [PATOC:GVG] subset: value_slim is_a: PATO:0002146 ! virulence is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002146 ! virulence intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal creation_date: 2009-10-30T05:13:10Z [Term] id: PATO:0002198 name: quality of a substance namespace: quality def: "A quality inhering in a bearer by virtue of its constitution." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001018 ! physical quality creation_date: 2010-03-15T04:35:27Z [Term] id: PATO:0002226 name: subcylindrical namespace: quality def: "A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical." [url:http\://www.thefreedictionary.com/Subcylindrical] subset: value_slim is_a: PATO:0001873 ! cylindrical creation_date: 2010-07-13T04:22:30Z [Term] id: PATO:0002254 name: flattened namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." [PATOC:CVS] comment: Becoming flat but not necessarily completely flat. subset: value_slim synonym: "compressed" RELATED [] is_a: PATO:0001591 ! curvature creation_date: 2010-08-16T03:59:34Z [Term] id: PATO:0002255 name: grooved namespace: quality def: "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." [PATOC:JE] subset: value_slim synonym: "channeled" RELATED [] synonym: "creased" RELATED [] is_a: PATO:0000150 ! texture creation_date: 2010-09-01T10:27:48Z [Term] id: PATO:0002266 name: 3-D shape namespace: quality def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON] is_a: PATO:0000052 ! shape creation_date: 2010-10-05T12:31:16Z [Term] id: PATO:0002287 name: increased elasticity namespace: quality def: "An elasticity which is relatively high." [PATOC:GVG] subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001171 ! elastic intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal creation_date: 2011-03-30T11:50:21Z [Term] id: PATO:0002288 name: decreased elasticity namespace: quality def: "An elasticity which is relatively low." [PATOC:GVG] subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001171 ! elastic intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal creation_date: 2011-03-30T11:50:39Z [Term] id: PATO:0002299 name: tubular namespace: quality def: "A cylindrical shape that is hollow." [PATOC:GVG] synonym: "tube like" EXACT [] synonym: "tube-shaped" EXACT [] synonym: "tubulate" EXACT [] is_a: PATO:0001873 ! cylindrical is_a: PATO:0002078 ! hollow creation_date: 2011-06-08T06:33:50Z [Term] id: PATO:0002300 name: increased quality namespace: quality def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal relationship: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal creation_date: 2011-06-16T06:39:43Z [Term] id: PATO:0002301 name: decreased quality namespace: quality def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal relationship: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal creation_date: 2011-06-16T06:40:15Z [Term] id: PATO:0002302 name: decreased process quality namespace: quality def: "A quality of a process that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal creation_date: 2011-06-16T06:50:59Z [Term] id: PATO:0002303 name: decreased object quality namespace: quality def: "A quality of an object that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal creation_date: 2011-06-16T06:51:54Z [Term] id: PATO:0002304 name: increased process quality namespace: quality def: "A quality of a process that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal creation_date: 2011-06-16T06:53:08Z [Term] id: PATO:0002305 name: increased object quality namespace: quality def: "A quality of an object that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal creation_date: 2011-06-16T06:54:01Z [Term] id: PATO:0002309 name: fiber shaped namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter." [PATOC:DC] comment: Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope). subset: value_slim is_a: PATO:0002226 ! subcylindrical creation_date: 2011-09-09T04:50:10Z [Term] id: PATO:0002318 name: superelliptic namespace: quality def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse] synonym: "Lamé curve" EXACT [] is_a: PATO:0002006 ! 2-D shape creation_date: 2011-10-12T12:45:16Z [Term] id: PATO:0002323 name: temporal distribution quality namespace: quality def: "A temporal distribution pattern of process occurrences within a regulation/reference process." [PATOC:LC] subset: attribute_slim is_a: PATO:0002062 ! physical quality of a process creation_date: 2011-11-22T01:12:28Z [Term] id: PATO:0002324 name: offset quality namespace: quality def: "The temporal relation between the end of the process with respect to a reference process." [PATOC:LC] subset: attribute_slim synonym: "completeness" RELATED [GOC:CJM] synonym: "extent" RELATED [GOC:CJM] is_a: PATO:0002323 ! temporal distribution quality creation_date: 2011-11-23T11:46:00Z [Term] id: PATO:0002325 name: onset quality namespace: quality def: "The temporal relation between the start of the process with respect to a reference process." [PATOC:LC] subset: attribute_slim synonym: "initiation" RELATED [] is_a: PATO:0002323 ! temporal distribution quality creation_date: 2011-11-23T11:47:34Z [Term] id: PATO:0002418 name: acidophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." [PATOC:GVG] comment: Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic. subset: mpath_slim subset: value_slim synonym: "eosinophilic" EXACT [] is_a: PATO:0070045 ! anatomical histological quality creation_date: 2012-12-17T03:01:19Z [Term] id: PATO:0002422 name: acinar namespace: quality def: "Pertaining to the individual parts making up an aggregate fruit like a many-lobed \"berry,\" such as a raspberry." [wikipedia:https\://en.wikipedia.org/wiki/Acinus] comment: Acinus is Latin for berry. subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure creation_date: 2012-12-17T03:11:10Z [Term] id: PATO:0002462 name: collagenous namespace: quality def: "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." [PATOC:WD] subset: value_slim is_a: PATO:0000025 ! composition creation_date: 2013-09-15T11:34:15Z [Term] id: PATO:0002478 name: transversely striated namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer." [PATOC:DS] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001410 ! striated creation_date: 2013-09-15T12:29:15Z [Term] id: PATO:0002505 name: nucleated namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality creation_date: 2013-10-21T05:44:34Z [Term] id: PATO:0010001 name: disconnected namespace: quality def: "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." [GOC:dos] is_a: PATO:0000141 ! structure creation_date: 2014-12-12T08:43:17Z [Term] id: PATO:0010006 name: cell morphology namespace: quality def: "A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure." [https://orcid.org/0000-0002-7073-9172] comment: Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts. is_a: PATO:0000051 ! morphology creation_date: 2021-01-23T11:31:53Z [Term] id: PATO:0015006 name: polymeric namespace: quality def: "A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array." [GOC:DOS, https://github.com/pato-ontology/pato/issues/78] comment: A complete coverage of this domain would subclasses homopolymeric, copolymeric, crystalline. subset: value_slim is_a: PATO:0000141 ! structure [Term] id: PATO:0040003 name: pathogenicity namespace: quality def: "The ability of a pathogen to produce an infectious disease or disorder in an another organism." [https://orcid.org/0000-0001-8941-3984] is_a: PATO:0001995 ! organismal quality [Term] id: PATO:0040072 name: high nuclear/cytoplasmic ratio namespace: quality def: "A quality inhering in a cell by virtue of the cell having a high nuclear/cytoplasmic ratio." [http://lymerick.net/blood-cells.pdf, Wikipedia:NC_ratio&oldid=931936284] comment: A high nuclear/cytolasmic ratio is 70% or higher. synonym: "high N:C ratio" EXACT [] is_a: PATO:0001396 ! cellular quality [Term] id: PATO:0045000 name: normal rate namespace: quality def: "A rate which is relatively normal." [] subset: mpath_slim subset: value_slim is_a: PATO:0000161 ! rate is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0000161 ! rate intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0045001 name: normal object quality namespace: quality def: "A quality of an object that has a value that is normal or average." [] is_a: PATO:0001241 ! physical object quality intersection_of: PATO:0001241 ! physical object quality intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal relationship: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-21T14:11:01Z [Term] id: PATO:0045010 name: normal concentration namespace: quality def: "A concentration which is relatively normal or average." [] subset: relational_slim subset: value_slim is_a: PATO:0001159 ! concentrated is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001159 ! concentrated intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045047 name: normal resistance to namespace: quality def: "A resistance to a stimulus which is relatively normal or average" [] subset: disposition_slim subset: relational_slim subset: value_slim is_a: PATO:0001178 ! resistant to is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0001178 ! resistant to intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045049 name: normal sensitivity toward namespace: quality def: "A sensitivity toward an external stimulus which is relatively normal or average" [] subset: disposition_slim subset: relational_slim subset: value_slim is_a: PATO:0000516 ! sensitive toward is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000516 ! sensitive toward intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045050 name: normal size namespace: quality def: "A size quality which is relatively normal or average" [] subset: value_slim is_a: PATO:0000117 ! size is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0000117 ! size intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045054 name: normal length namespace: quality def: "A length quality which is relatively normal or average" [] subset: value_slim is_a: PATO:0000122 ! length is_a: PATO:0045050 ! normal size intersection_of: PATO:0000122 ! length intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045073 name: normal process quality namespace: quality def: "A quality of a process that has a value that is normal or average." [] is_a: PATO:0001236 ! process quality intersection_of: PATO:0001236 ! process quality intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal relationship: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-21T14:11:01Z [Term] id: PATO:0045080 name: normal virulence namespace: quality def: "A virulence which is relatively normal or average" [] subset: value_slim is_a: PATO:0002146 ! virulence is_a: PATO:0045001 ! normal object quality intersection_of: PATO:0002146 ! virulence intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal creation_date: 2017-12-22T14:16:43Z [Term] id: PATO:0045084 name: normal duration namespace: quality def: "A duration quality of a process which is relatively normal." [] subset: value_slim is_a: PATO:0001309 ! duration is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0001309 ! duration intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0045086 name: normal occurrence namespace: quality def: "An occurrence which is relatively normal." [] subset: value_slim is_a: PATO:0000057 ! occurrence is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0000057 ! occurrence intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0045088 name: normal sensitivity of a process namespace: quality def: "A sensitivity of a process which is relatively normal." [] subset: relational_slim subset: value_slim is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0045073 ! normal process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal [Term] id: PATO:0070002 name: basket cell morphology namespace: quality def: "A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells." [doi:10.1016/b978-0-12-369497-3.10004-4, WikipediaVersioned:Basket_cell&oldid=951703880] xref: ILX:0101123 xref: ilxtr:BasketPhenotype xref: nifext:3 is_a: PATO:0070026 ! multipolar neuron morphology [Term] id: PATO:0070010 name: stellate morphology namespace: quality def: "A cell morphology that inheres in neurons that have dendritic processes radiating from the cell body forming a star-like shape." [ISBN:9780123973481] xref: ILX:0111036 xref: SAO:9271919883 is_a: PATO:0070026 ! multipolar neuron morphology [Term] id: PATO:0070025 name: unipolar neuron morphology namespace: quality def: "A cell morphology that inheres in neurons with only one process, a neurite, that extends from the cell body. The neurite then branches to form dendritic and axonal processes." [WikipediaVersioned:Unipolar_neuron&oldid=994458581] is_a: PATO:0010006 ! cell morphology [Term] id: PATO:0070026 name: multipolar neuron morphology namespace: quality def: "A cell morphology that inheres in neurons which possess three or more neurites, usually a single axon and many dendrites and dendritic branches." [WikipediaVersioned:Multipolar_neuron&oldid=1022942606] xref: ILX:0107196 xref: NLX:378 is_a: PATO:0010006 ! cell morphology [Term] id: PATO:0070044 name: anatomical structure quality namespace: quality def: "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." [] is_a: PATO:0001241 ! physical object quality created_by: http://orcid.org/0000-0001-7258-9596 [Term] id: PATO:0070045 name: anatomical histological quality namespace: quality def: "A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes." [] is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0070046 name: neutrophillic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: PATO:0070045 ! anatomical histological quality [Term] id: PATO:0070047 name: polychromatophilic namespace: quality def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." [GOC:add] is_a: PATO:0070045 ! anatomical histological quality [Term] id: PATO:0070060 name: quality of interaction of a substance with electromagnetic radiation namespace: quality def: "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." [https://orcid.org/0000-0002-5111-7263] subset: attribute_slim is_a: PATO:0002198 ! quality of a substance [Term] id: PATO:0103000 name: quantitative namespace: quality def: "A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value." [https://libguides.macalester.edu/c.php?g=527786&p=3608639, https://www.nnlm.gov/guides/data-glossary/quantitative-data] is_a: PATO:0000001 ! quality created_by: https://orcid.org/0000-0001-8314-2140 [Term] id: PHIPO:0000001 name: pathogen host interaction phenotype namespace: pathogen_host_interaction_phenotype def: "Any of the set of observable characteristics arising from the interaction of a potentially pathogenic organism with a host organism." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000505 ! phenotype created_by: alaynecuzick creation_date: 2018-05-02T11:20:17Z [Term] id: PHIPO:0000002 name: single species phenotype namespace: single_species_phenotype def: "Any of the set of observable characteristics of a single organism resulting from the interaction of its genotype with the environment." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000505 ! phenotype created_by: alaynecuzick creation_date: 2018-05-02T11:20:59Z [Term] id: PHIPO:0000003 name: tissue phenotype namespace: single_species_phenotype def: "A single organism phenotype that is observed at the level of a tissue (eg leaf, inflorescence, ear or kidney)." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000402 ! individual organism phenotype created_by: alaynecuzick creation_date: 2018-05-02T11:21:13Z [Term] id: PHIPO:0000004 name: unaffected pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen, to produce an infectious disease in another organism is unaffected (i.e the same as wild-type, it could be pathogenic or non-pathogenic)." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. subset: qc_extension_only synonym: "normal pathogenicity" EXACT [] synonym: "unaffected disease causing ability" EXACT [] synonym: "unaltered pathogenicity" EXACT [] synonym: "unchanged pathogenicity" EXACT [] is_a: PHIPO:0000006 ! pathogenicity phenotype created_by: alaynecuzick creation_date: 2018-05-04T12:38:43Z [Term] id: PHIPO:0000005 name: obsolete abnormal pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the pathogenicity is abnormal (i.e different than wild-type)" [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T12:39:00Z [Term] id: PHIPO:0000006 name: pathogenicity phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that is relevant to pathogenicity. Pathogenicity is the ability of an organism, a pathogen, to produce an infectious disease in another organism" [] comment: Can only apply to changes in the pathogen. Pathogenicity is a qualitative concept. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "disease causing ability" EXACT [] synonym: "pathogenesis (related)" RELATED [] is_a: PHIPO:0001179 ! infective ability phenotype created_by: alaynecuzick creation_date: 2018-05-04T12:39:55Z [Term] id: PHIPO:0000007 name: obsolete functional pathogen effector absent namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen effector to produce an infectious disease is absent." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. subset: qc_do_not_annotate synonym: "disease causing ability absent" EXACT [] synonym: "pathogenic ability absent" BROAD [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T12:42:00Z [Term] id: PHIPO:0000008 name: obsolete functional pathogen effector present namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen effector to produce an infectious disease is present." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. subset: qc_do_not_annotate synonym: "disease causing ability present" EXACT [] synonym: "pathogenic ability present" BROAD [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T12:42:16Z [Term] id: PHIPO:0000009 name: gain of pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen, to produce an infectious disease in another organism is obtained (pathogenicity was absent and is now present)." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. Note that this ability to cause pathogenicity is a feature of the pathogen. Therefore gain/loss of pathogenicity should never be dependent on changes to the host genotype, only on changes to the pathogen genotype. If you are annotating changes in disease presence or absence dependent on the changes to the host consider increased/decreased virulence phenotypes. subset: qc_extension_only synonym: "gain of disease causing ability" EXACT [] is_a: PHIPO:0000006 ! pathogenicity phenotype created_by: alaynecuzick creation_date: 2018-05-04T12:45:12Z [Term] id: PHIPO:0000010 name: loss of pathogenicity namespace: pathogen_host_interaction_phenotype def: "A phenotype where the ability of a pathogen, to produce an infectious disease in another organism is abolished (pathogenicity was present and is now absent)." [] comment: For use in the annotation extension infective ability. Can only apply to changes in the pathogen. Note that this ability to cause pathogenicity is a feature of the pathogen. Therefore gain/loss of pathogenicity should never be dependent on changes to the host genotype, only on changes to the pathogen genotype. If you are annotating changes in disease presence or absence dependent on the changes to the host consider increased/decreased virulence phenotypes. Note that avirulence means loss of/abolished virulence in plant pathology terminology. subset: qc_extension_only synonym: "abolished pathogenicity" EXACT [] synonym: "loss of disease causing ability" EXACT [] is_a: PHIPO:0000006 ! pathogenicity phenotype created_by: alaynecuzick creation_date: 2018-05-04T12:45:31Z [Term] id: PHIPO:0000011 name: virulence phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype that is relevant to virulence. Virulence is the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism. (Virulence is observed where pathogenicity is present)." [] comment: Can apply to changes in the pathogen or the host. Virulence is a quantitative concept subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "disease severity" EXACT [] is_a: PHIPO:0001179 ! infective ability phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:02:03Z [Term] id: PHIPO:0000012 name: unaffected virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is unchanged (i.e. the same degree of infectious disease as wild-type interaction)." [] comment: For use in the annotation extension infective ability. Can apply to changes in the pathogen or the host. subset: qc_do_not_annotate synonym: "normal virulence" EXACT [] synonym: "unaffected disease severity" EXACT [] is_a: PHIPO:0000011 ! virulence phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:02:23Z [Term] id: PHIPO:0000013 name: obsolete abnormal virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where virulence is abnormal (i.e. different than wild-type)." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T13:02:39Z [Term] id: PHIPO:0000014 name: increased virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is increased (i.e. more symptoms than normal)." [] comment: For use in the annotation extension infective ability. Can apply to changes in the pathogen or the host. subset: qc_extension_only synonym: "hypervirulence" EXACT [] synonym: "increased disease severity" EXACT [] is_a: PHIPO:0000011 ! virulence phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:07:31Z [Term] id: PHIPO:0000015 name: reduced virulence namespace: pathogen_host_interaction_phenotype def: "A phenotype where the degree to which a pathogen (species or strain) is able to cause infectious disease in another organism is decreased (i.e. fewer symptoms than normal)." [] comment: For use in the annotation extension infective ability. Can apply to changes in the pathogen or the host. subset: qc_extension_only synonym: "decreased virulence" EXACT [] synonym: "reduced disease severity" EXACT [] is_a: PHIPO:0000011 ! virulence phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:08:10Z [Term] id: PHIPO:0000016 name: normal single species phenotype namespace: single_species_phenotype def: "A single organism phenotype which is normal (i.e. the same as wild-type)." [] is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:10:48Z [Term] id: PHIPO:0000017 name: abnormal single species phenotype namespace: single_species_phenotype def: "A single organism phenotype which is abnormal (i.e. different than wild-type)." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000002 ! single species phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:11:04Z [Term] id: PHIPO:0000018 name: lipid droplets present in decreased numbers namespace: single_species_phenotype def: "A single species phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer lipid droplets than normal." [] xref: FYPO:0002552 is_a: PHIPO:0000474 ! abnormal number of lipid droplets created_by: alaynecuzick creation_date: 2018-05-04T13:12:20Z [Term] id: PHIPO:0000019 name: inviable cell namespace: single_species_phenotype def: "A lethal single organism cell level phenotype resulting from altering a gene product that is essential for the life of the organism." [] synonym: "essential" RELATED [] synonym: "lethal" RELATED [] is_a: PHIPO:0001222 ! cell viability phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:12:47Z [Term] id: PHIPO:0000021 name: increased sensitivity to chemical namespace: single_species_phenotype alt_id: PHIPO:0000020 def: "A growth phenotype which describes the sensitivity of individuals or populations after exposure to a specific chemical. Typically, organisms are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type individuals or populations to grow." [] synonym: "decreased resistance to chemical" EXACT [] synonym: "increased sensitivity to chemical during growth" RELATED [] is_a: PHIPO:0001218 ! chemical phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:15:05Z [Term] id: PHIPO:0000022 name: increased resistance to chemical namespace: single_species_phenotype alt_id: PHIPO:0000412 def: "A growth phenotype which describes the resistance of individuals or populations after exposure to a specific chemical. Typically, organisms are deemed resistant to a chemical if they survive at a concentration of the chemical that does not allow wild type individuals or populations to grow." [] synonym: "increased resistance to chemical during growth" RELATED [] is_a: PHIPO:0001218 ! chemical phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:16:06Z [Term] id: PHIPO:0000023 name: obsolete abnormal penetration assay phenotype namespace: single_species_phenotype def: "A pathogen penetration assay phenotype (assessing the organism's ability to penetrate a given substance/membrane) which is abnormal (i.e. different than wild-type)." [] subset: pathogen_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T13:16:54Z [Term] id: PHIPO:0000024 name: pathogen penetration across the barrier present namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in which pathogen penetration of a given experimental substance/membrane is present." [] subset: pathogen_phenotype is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:17:08Z [Term] id: PHIPO:0000025 name: obsolete normal mating phenotype prior to penetration namespace: single_species_phenotype comment: Is this a bit too specific? should this be with sexual reproduction? eg ustilago and rust fungus MU agrees REMOVE from penetration is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T13:17:46Z [Term] id: PHIPO:0000026 name: obsolete normal penetration namespace: single_species_phenotype def: "A pathogen phenotype indicating that the pathogen is able to penetrate a given experimental substance/membrane in the same manner as the wild-type." [] subset: pathogen_phenotype synonym: "no penetration defect" EXACT [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T13:18:03Z [Term] id: PHIPO:0000027 name: normal pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is normal (i.e indistinguishable from wild type)." [] subset: pathogen_phenotype synonym: "normal pathogen post penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:19:13Z [Term] id: PHIPO:0000028 name: normal formation of pathogen penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the formation of the pathogen penetration structure is normal (i.e same as wild-type) when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "normal formation of pathogen infection structure" EXACT [] synonym: "normal pathogen pre penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:19:44Z [Term] id: PHIPO:0000029 name: obsolete abnormal mating phenotype prior to penetration namespace: single_species_phenotype comment: Is this a bit too specific? should this be with reproduction? is_obsolete: true created_by: alaynecuzick creation_date: 2018-05-04T13:22:14Z [Term] id: PHIPO:0000030 name: pathogen penetration across the barrier absent namespace: single_species_phenotype def: "A single species pathogen penetration phenotype in which pathogen penetration of a given experimental substance/membrane is absent." [] subset: pathogen_phenotype synonym: "penetration defect" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:22:31Z [Term] id: PHIPO:0000031 name: abnormal pathogen growth after penetration of the barrier namespace: single_species_phenotype def: "A single species phenotype in which the pathogen's ability to contine to grow after penetration of a given experimental substance/membrane in an in vitro assay is abnormal (i.e indistinguishable from wild type)." [] subset: pathogen_phenotype synonym: "abnormal pathogen post penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:22:52Z [Term] id: PHIPO:0000032 name: abnormal formation of pathogen penetration structure namespace: single_species_phenotype def: "A single species pathogen growth phenotype in which the formation of the pathogen penetration structure is abnormal (i.e different than wild-type) when assessed for penetration ability on a given experimental substance/membrane." [] subset: pathogen_phenotype synonym: "abnormal formation of pathogen infection structure" EXACT [] synonym: "abnormal pathogen pre penetration" EXACT [] is_a: PHIPO:0000160 ! pathogen penetration across barrier phenotype created_by: alaynecuzick creation_date: 2018-05-04T13:23:06Z [Term] id: PHIPO:0000033 name: obsolete abnormal pathogen growth on host surface namespace: pathogen_host_interaction_phenotype def: "A pathogen colonization of host phenotype where the vegetative growth or proliferation of the pathogen on the host surface is abnormal." [] is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-04T13:41:02Z [Term] id: PHIPO:0000034 name: cell phenotype namespace: single_species_phenotype def: "A single species phenotype that is observed at the level of an individual cell." [] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate xref: FYPO:0000002 is_a: PHIPO:0000402 ! individual organism phenotype created_by: alaynecuzick creation_date: 2018-07-04T13:41:14Z [Term] id: PHIPO:0000035 name: mutualism present namespace: pathogen_host_interaction_phenotype def: "A pathogen host phenotype where the mutualism phenotype is normal (i.e. the same as wild-type), and the wild-type interaction exhibits mutualism." [] subset: qc_extension_only is_a: PHIPO:0000039 ! normal mutualism created_by: alaynecuzick creation_date: 2018-07-09T13:41:47Z [Term] id: PHIPO:0000036 name: abnormal lipid droplet morphology namespace: single_species_phenotype def: "A single organism phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of lipid droplets is abnormal." [] xref: FYPO:0000356 is_a: PHIPO:0000478 ! lipid droplet phenotype created_by: alaynecuzick creation_date: 2019-01-14T12:21:13Z [Term] id: PHIPO:0000038 name: mutualism phenotype namespace: pathogen_host_interaction_phenotype def: "A phenotype which affects the balance of symbiotic mutualism, mutualism describes an interaction between two symbionts (where the larger is usually the host), results in positive (beneficial) effects on reproduction and/or survival of both species." [] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0001179 ! infective ability phenotype created_by: alaynecuzick creation_date: 2018-07-10T11:52:04Z [Term] id: PHIPO:0000039 name: normal mutualism namespace: pathogen_host_interaction_phenotype def: "A phenotype in which the interaction is the same as the wild-type, no asymptomatic colonisation or disease formation symptoms are visible." [] comment: Logical definition mutualism (GO:0085030) and (has_relative_magnitude some normal (PATO:0000461)) subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000038 ! mutualism phenotype created_by: alaynecuzick creation_date: 2018-07-10T11:52:33Z [Term] id: PHIPO:0000040 name: abnormal mutualism namespace: pathogen_host_interaction_phenotype def: "A phenotype in which the balance of symbiotic mutualism has been disrupted compared to the normal interaction." [] comment: Logical definition mutualism (GO:0085030) and (has_relative_magnitude some abnormal (PATO:0000460)) need to choose correct language for term name subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: PHIPO:0000038 ! mutualism phenotype created_by: alaynecuzick creation_date: 2018-07-10T11:53:05Z [Term] id: PHIPO:0000041 name: obsolete normal motility phenotype namespace: single_species_phenotype comment: bacteria flagella aphid flight nematode wiggle fungi non-motile (apart from spores) also hosts is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T11:54:28Z [Term] id: PHIPO:0000042 name: obsolete abnormal motility phenotype namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T11:54:54Z [Term] id: PHIPO:0000043 name: abnormal reproduction phenotype namespace: single_species_phenotype def: "A single species phenotype where reproduction is abnormal." [] is_a: PHIPO:0000161 ! reproductive phenotype created_by: alaynecuzick creation_date: 2018-07-13T11:57:47Z [Term] id: PHIPO:0000044 name: normal reproduction phenotype namespace: single_species_phenotype def: "A single species phenotype where reproduction is normal (indistinguishable from wild type)." [] is_a: PHIPO:0000161 ! reproductive phenotype created_by: alaynecuzick creation_date: 2018-07-13T11:58:15Z [Term] id: PHIPO:0000045 name: normal asexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the asexual reproduction process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process is normal (indistinguishable from wild type)(GO:0019954)." [] synonym: "normal parthenogenesis" RELATED [] is_a: PHIPO:0000044 ! normal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:08:15Z [Term] id: PHIPO:0000046 name: normal sexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the sexual reproduction process in which new individuals are produced by combining the genetic material of two gametes, which may come from two organisms or from a single organism is normal (indistinguishable from wild type) (GO:0019953)." [] is_a: PHIPO:0000044 ! normal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:09:04Z [Term] id: PHIPO:0000047 name: abnormal asexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the asexual reproduction process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process is abnormal (GO:0019954)." [] synonym: "abnormal parthenogenesis" RELATED [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:09:49Z [Term] id: PHIPO:0000048 name: abnormal sexual reproduction namespace: single_species_phenotype def: "A single species phenotype where the sexual reproduction process in which new individuals are produced by combining the genetic material of two gametes, which may come from two organisms or from a single organism is abnormal (GO:0019953)." [] is_a: PHIPO:0000043 ! abnormal reproduction phenotype created_by: alaynecuzick creation_date: 2018-07-13T12:10:14Z [Term] id: PHIPO:0000049 name: increased number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is increased." [] is_a: PHIPO:0000073 ! abnormal number of sexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:16:49Z [Term] id: PHIPO:0000050 name: decreased number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is decreased." [] is_a: PHIPO:0000073 ! abnormal number of sexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:17:15Z [Term] id: PHIPO:0000051 name: increased number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is increased." [] synonym: "increased number of conidia" EXACT [] is_a: PHIPO:0000082 ! abnormal number of asexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:18:08Z [Term] id: PHIPO:0000052 name: decreased number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is decreased." [] synonym: "decreased number of conidia" EXACT [] synonym: "fewer conidia" EXACT [] is_a: PHIPO:0000082 ! abnormal number of asexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:18:34Z [Term] id: PHIPO:0000053 name: delayed asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of asexual spore formation happens later than normal." [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:20:33Z [Term] id: PHIPO:0000054 name: premature asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of asexual spore formation happens sooner than normal." [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:22:31Z [Term] id: PHIPO:0000055 name: delayed sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of sexual spore formation happens later than normal." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:23:43Z [Term] id: PHIPO:0000056 name: premature sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype in which the occurrence of sexual spore formation happens sooner than normal." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:24:07Z [Term] id: PHIPO:0000057 name: normal number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is normal (i.e. indistinguishable from wild type)." [] is_a: PHIPO:0000079 ! normal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:25:33Z [Term] id: PHIPO:0000058 name: obsolete normal timing in production of sexual spores namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:26:14Z [Term] id: PHIPO:0000059 name: normal number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is normal (i.e. indistinguishable from wild type)." [] synonym: "normal number of conidia" EXACT [] is_a: PHIPO:0000080 ! normal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:27:14Z [Term] id: PHIPO:0000060 name: obsolete normal timing in production of asexual spores namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:27:45Z [Term] id: PHIPO:0000061 name: asexual spores absent namespace: single_species_phenotype def: "A reproductive phenotype where asexual spores are absent (FAO:0000023)." [] synonym: "conidia absent" EXACT [] is_a: PHIPO:0000082 ! abnormal number of asexual spores created_by: alaynecuzick creation_date: 2018-07-13T12:28:57Z [Term] id: PHIPO:0000062 name: sexual spores absent namespace: single_species_phenotype def: "A reproductive phenotype where sexual spores are absent (FAO:0000017)." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:29:31Z [Term] id: PHIPO:0000063 name: sexual spores present namespace: single_species_phenotype def: "A reproductive phenotype where asexual spores are present (FAO:0000017). The product of meiosis." [] is_a: PHIPO:0000079 ! normal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:29:58Z [Term] id: PHIPO:0000064 name: asexual spores present namespace: single_species_phenotype def: "A reproductive phenotype where asexual spores are present (FAO:0000023). The product of mitosis." [] synonym: "conidia present" EXACT [] is_a: PHIPO:0000080 ! normal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:30:18Z [Term] id: PHIPO:0000065 name: asexual spores increased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the asexual spore is increased." [] synonym: "conidia increased in size" EXACT [] is_a: PHIPO:0000081 ! abnormal asexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:32:36Z [Term] id: PHIPO:0000066 name: obsolete abnormal timing of asexual spore production namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:33:03Z [Term] id: PHIPO:0000067 name: asexual spores decreased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the asexual spore is decreased." [] synonym: "conidia decreased in size" EXACT [] is_a: PHIPO:0000081 ! abnormal asexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:36:00Z [Term] id: PHIPO:0000068 name: sexual spores increased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the sexual spore is increased." [] is_a: PHIPO:0000071 ! abnormal sexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:37:29Z [Term] id: PHIPO:0000069 name: sexual spores decreased in size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the sexual spore is decreased." [] is_a: PHIPO:0000071 ! abnormal sexual spore size created_by: alaynecuzick creation_date: 2018-07-13T12:37:52Z [Term] id: PHIPO:0000070 name: altered in pigment accumulation in sexual spore namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in a sexual spore cell is altered." [] is_a: PHIPO:0000285 ! abnormal cellular pigment accumulation created_by: alaynecuzick creation_date: 2018-07-13T12:38:19Z [Term] id: PHIPO:0000071 name: abnormal sexual spore size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the sexual spore is abnormal." [] is_a: PHIPO:0000130 ! abnormal sexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T12:39:04Z [Term] id: PHIPO:0000072 name: abnormal sexual spore shape namespace: single_species_phenotype def: "A reproductive morphology phenotype where the shape of the sexual spore is abnormal." [] is_a: PHIPO:0000130 ! abnormal sexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T12:39:34Z [Term] id: PHIPO:0000073 name: abnormal number of sexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of sexual spores is abnormal." [] is_a: PHIPO:0000077 ! abnormal sexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T12:40:05Z [Term] id: PHIPO:0000074 name: obsolete abnormal timing of sexual spore production namespace: single_species_phenotype is_obsolete: true created_by: alaynecuzick creation_date: 2018-07-13T12:42:05Z [Term] id: PHIPO:0000075 name: abnormal asexual spore shape namespace: single_species_phenotype def: "A reproductive morphology phenotype where the shape of the asexual spore is abnormal." [] synonym: "abnormal conidia shape" EXACT [] is_a: PHIPO:0000127 ! abnormal asexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T12:43:06Z [Term] id: PHIPO:0000076 name: altered in pigment accumulation in asexual spore namespace: single_species_phenotype def: "A single species individual organism phenotype where the accumulation of coloring matter in an asexual spore cell is altered." [] synonym: "altered in pigment accumulation in conidia" EXACT [] is_a: PHIPO:0000285 ! abnormal cellular pigment accumulation created_by: alaynecuzick creation_date: 2018-07-13T12:43:42Z [Term] id: PHIPO:0000077 name: abnormal sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of sexual sporulation, the formation of spores from the products of meiosis, is abnormal (GO:0034293)." [] synonym: "abnormal meiotic sporulation" EXACT [] synonym: "abnormal sexual spore formation" EXACT [] is_a: PHIPO:0000048 ! abnormal sexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:54:33Z [Term] id: PHIPO:0000078 name: abnormal asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of asexual sporulation, the formation of spores derived from the products of an asexual cell division, is abnormal (GO:0030436)." [] synonym: "abnormal asexual spore formation" EXACT [] synonym: "abnormal mitotic sporulation" EXACT [] is_a: PHIPO:0000047 ! abnormal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:55:38Z [Term] id: PHIPO:0000079 name: normal sexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of sexual sporulation, the formation of spores from the products of meiosis, is normal (GO:0034293)." [] synonym: "normal meiotic sporulation" EXACT [] synonym: "normal sexual spore formation" EXACT [] is_a: PHIPO:0000046 ! normal sexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:56:11Z [Term] id: PHIPO:0000080 name: normal asexual sporulation namespace: single_species_phenotype def: "A reproductive phenotype where the process of asexual sporulation, the formation of spores derived from the products of an asexual cell division, is normal (GO:0030436)." [] synonym: "normal asexual spore formation" EXACT [] synonym: "normal mitotic sporulation" EXACT [] is_a: PHIPO:0000045 ! normal asexual reproduction created_by: alaynecuzick creation_date: 2018-07-13T12:57:46Z [Term] id: PHIPO:0000081 name: abnormal asexual spore size namespace: single_species_phenotype def: "A reproductive morphology phenotype where the size of the asexual spore is abnormal." [] synonym: "abnormal conidia size" EXACT [] is_a: PHIPO:0000127 ! abnormal asexual spore morphology created_by: alaynecuzick creation_date: 2018-07-13T13:08:40Z [Term] id: PHIPO:0000082 name: abnormal number of asexual spores namespace: single_species_phenotype def: "A population phenotype in which the frequency of occurrence of asexual spores is abnormal." [] synonym: "abnormal number of conidia" EXACT [] is_a: PHIPO:0000078 ! abnormal asexual sporulation created_by: alaynecuzick creation_date: 2018-07-13T13:09:40Z