format-version: 1.2
data-version: releases/2026-03-12
subsetdef: 1:STAR ""
subsetdef: 1_STAR ""
subsetdef: 2:STAR ""
subsetdef: 3:STAR ""
subsetdef: 3_STAR ""
subsetdef: abnormal_slim ""
subsetdef: absent_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim ""
subsetdef: cell_quality ""
subsetdef: cellxgene_subset ""
subsetdef: common_anatomy ""
subsetdef: cumbo ""
subsetdef: developmental_classification ""
subsetdef: disposition_slim ""
subsetdef: early_development ""
subsetdef: efo_slim ""
subsetdef: emapa_ehdaa2 ""
subsetdef: eye_upper_slim ""
subsetdef: functional_classification ""
subsetdef: general_cell_types_upper_slim ""
subsetdef: gocheck_do_not_annotate ""
subsetdef: gocheck_obsoletion_candidate ""
subsetdef: goslim_agr ""
subsetdef: goslim_candida ""
subsetdef: goslim_chembl ""
subsetdef: goslim_drosophila ""
subsetdef: goslim_euk_cellular_processes_ribbon ""
subsetdef: goslim_flybase_ribbon ""
subsetdef: goslim_generic ""
subsetdef: goslim_metagenomics ""
subsetdef: goslim_mouse ""
subsetdef: goslim_pir ""
subsetdef: goslim_plant ""
subsetdef: goslim_plant_ribbon ""
subsetdef: goslim_pombe ""
subsetdef: goslim_prokaryote ""
subsetdef: goslim_prokaryote_ribbon ""
subsetdef: goslim_synapse ""
subsetdef: goslim_virus ""
subsetdef: goslim_yeast ""
subsetdef: grouping_class ""
subsetdef: homology_grouping ""
subsetdef: hpo_slim ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: human_reference_atlas ""
subsetdef: human_subset ""
subsetdef: inconsistent_with_fma ""
subsetdef: major_organ ""
subsetdef: mouse_subset ""
subsetdef: mpath_slim ""
subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
subsetdef: uberon_slim ""
subsetdef: ubprop:upper_level ""
subsetdef: unverified_taxonomic_grouping ""
subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
idspace: dc http://purl.org/dc/elements/1.1/ 
idspace: foaf http://xmlns.com/foaf/0.1/ 
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
idspace: swrl http://www.w3.org/2003/11/swrl# 
idspace: swrla http://swrl.stanford.edu/ontologies/3.3/swrla.owl# 
idspace: swrlb http://www.w3.org/2003/11/swrlb# 
idspace: terms http://purl.org/dc/terms/ 
ontology: phipo
property_value: dc:description "Ontology of species-neutral phenotypes observed in pathogen-host interactions." xsd:string
property_value: dc:title "Pathogen Host Interactions Phenotype Ontology" xsd:string
property_value: owl:versionInfo "2026-03-12" xsd:string
property_value: terms:license "https://creativecommons.org/licenses/by/3.0/" xsd:string
creation_date: 2018-07-09T13:43:00Z
created_by: alaynecuzick

[Term]
id: BFO:0000001
name: entity

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
is_a: BFO:0000001 ! entity
disjoint_from: BFO:0000003 ! occurrent
relationship: BFO:0000050 BFO:0000002 {all_only="true"} ! part of continuant

[Term]
id: BFO:0000003
name: occurrent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []
is_a: BFO:0000001 ! entity
relationship: BFO:0000050 BFO:0000003 {all_only="true"} ! part of occurrent

[Term]
id: BFO:0000004
name: independent continuant
def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: BFO:0000050 BFO:0000004 {all_only="true"} ! part of independent continuant

[Term]
id: BFO:0000015
name: process
def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
is_a: BFO:0000003 ! occurrent

[Term]
id: BFO:0000016
name: disposition
is_a: BFO:0000017 ! realizable entity
disjoint_from: BFO:0000023 ! role

[Term]
id: BFO:0000017
name: realizable entity
def: "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." []
is_a: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000019 ! quality
relationship: BFO:0000050 BFO:0000017 {all_only="true"} ! part of realizable entity

[Term]
id: BFO:0000019
name: quality
is_a: BFO:0000020 ! specifically dependent continuant
relationship: BFO:0000050 BFO:0000019 {all_only="true"} ! part of quality

[Term]
id: BFO:0000020
name: specifically dependent continuant
def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." []
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: BFO:0000050 BFO:0000020 {all_only="true"} ! part of specifically dependent continuant

[Term]
id: BFO:0000023
name: role
def: "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts." []
is_a: BFO:0000017 ! realizable entity

[Term]
id: BFO:0000031
name: generically dependent continuant
def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." []
is_a: BFO:0000002 ! continuant
relationship: BFO:0000050 BFO:0000031 {all_only="true"} ! part of generically dependent continuant

[Term]
id: BFO:0000034
name: function
is_a: BFO:0000016 ! disposition

[Term]
id: BFO:0000040
name: material entity
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant
disjoint_from: BFO:0000141

[Term]
id: CARO:0000000
name: anatomical entity
def: "A part of a multicellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex.  Or, a substance produced by a multicellular organism with granularity above the level of a protein complex." []
is_a: BFO:0000040 ! material entity
disjoint_from: IDO:0000528 ! pathogen

[Term]
id: CHEBI:100147
name: nalidixic acid
namespace: chebi_ontology
alt_id: CHEBI:7456
def: "A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of <em>E. coli</em>, <em>Enterobacter</em>, <em>Klebsiella</em>, and <em>Proteus</em> species." []
subset: 3:STAR
synonym: "1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid" RELATED [chemidplus]
synonym: "1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure" RELATED [chemidplus]
synonym: "1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid" RELATED [chemidplus]
synonym: "1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid" RELATED [chemidplus]
synonym: "1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid" RELATED [chembl]
synonym: "3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one" RELATED [chemidplus]
synonym: "NALIDIXIC ACID" RELATED [chembl]
synonym: "Nalidixic acid" RELATED [kegg.compound]
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:73537 ! 1,8-naphthyridine derivative
is_a: CHEBI:86324 ! quinolone antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0018034 CHEBI:62070 ! nalidixic acid anion

[Term]
id: CHEBI:10022
name: deoxynivalenol
namespace: chebi_ontology
def: "A trichothecene mycotoxin produced by <em>Fusarium</em> to which wheat, barley, maize (corn) and their products are susceptible to contamination." []
subset: 3:STAR
synonym: "3alpha,7alpha,15-trihydroxy-12,13-epoxytrichothec-9-en-8-one" RELATED [chemidplus]
synonym: "4-Deoxynivalenol" RELATED [chemidplus]
synonym: "4-Desoxynivalenol" RELATED [chemidplus]
synonym: "Dehydronivalenol" RELATED [chemidplus]
synonym: "Desoxynivalenol" RELATED [chemidplus]
synonym: "DON" RELATED [kegg.compound]
synonym: "Vomitoxin" RELATED [kegg.compound]
is_a: CHEBI:15734 ! primary alcohol
is_a: CHEBI:2468 ! secondary alpha-hydroxy ketone
is_a: CHEBI:27136 ! triol
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:51689 ! enone
is_a: CHEBI:55517 ! trichothecene

[Term]
id: CHEBI:10023
name: voriconazole
namespace: chebi_ontology
alt_id: CHEBI:127308
def: "A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by <em>Scedosporium apiospermum</em> and <em>Fusarium</em> spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4." []
subset: 3:STAR
synonym: "(alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol" RELATED [chemidplus]
synonym: "(R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol" RELATED [chebi]
synonym: "VCZ" RELATED [drugbank]
synonym: "voriconazole" RELATED [uniprot_ft]
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:38582 ! difluorobenzene
is_a: CHEBI:39447 ! pyrimidines
is_a: CHEBI:87071 ! conazole antifungal drug
is_a: CHEBI:87101 ! triazole antifungal drug
relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor

[Term]
id: CHEBI:100241
name: ciprofloxacin
namespace: chebi_ontology
alt_id: CHEBI:102718
alt_id: CHEBI:3717
alt_id: CHEBI:41638
def: "A  quinolone that is quinolin-4(1<em>H</em>)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively." []
subset: 3:STAR
synonym: "1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [chemidplus]
synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid" RELATED [chembl]
synonym: "1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid" RELATED [chembl]
synonym: "1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID" RELATED [pdb-ccd]
synonym: "1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid" RELATED [chembl]
synonym: "1-Cyclopropyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid" RELATED [chembl]
synonym: "1-cyclopropyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid" RELATED [chembl]
synonym: "Ciprofloxacin" RELATED [kegg.compound]
synonym: "ciprofloxacin" RELATED [chembl]
is_a: CHEBI:23765 ! quinolone
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:36709 ! aminoquinoline
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:51454 ! cyclopropanes
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0018033 CHEBI:192486 ! ciprofloxacin(1+)
relationship: RO:0018036 CHEBI:192484 ! ciprofloxacin zwitterion

[Term]
id: CHEBI:100246
name: norfloxacin
namespace: chebi_ontology
alt_id: CHEBI:7629
def: "A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase." []
subset: 3:STAR
synonym: "1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [chemidplus]
synonym: "1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure" RELATED [chemidplus]
synonym: "1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid" RELATED [chemidplus]
synonym: "NFLX" RELATED [kegg.drug]
is_a: CHEBI:23765 ! quinolone
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant

[Term]
id: CHEBI:102484
name: sulfisoxazole
namespace: chebi_ontology
alt_id: CHEBI:9343
def: "A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms." []
subset: 3:STAR
synonym: "3,4-Dimethyl-5-sulfanilamidoisoxazole" RELATED [chemidplus]
synonym: "3,4-Dimethyl-5-sulfonamidoisoxazole" RELATED [chemidplus]
synonym: "3,4-Dimethyl-5-sulphanilamidoisoxazole" RELATED [chemidplus]
synonym: "3,4-Dimethyl-5-sulphonamidoisoxazole" RELATED [chemidplus]
synonym: "3,4-Dimethylisoxazole-5-sulfanilamide" RELATED [chemidplus]
synonym: "3,4-Dimethylisoxazole-5-sulphanilamide" RELATED [chemidplus]
synonym: "4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide" RELATED [nist]
synonym: "4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide" RELATED [chemidplus]
synonym: "5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole" RELATED [chemidplus]
synonym: "5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole" RELATED [chemidplus]
synonym: "5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole" RELATED [chemidplus]
synonym: "5-Sulfanilamido-3,4-dimethylisoxazole" RELATED [chemidplus]
synonym: "5-Sulphanilamido-3,4-dimethyl-isoxazole" RELATED [chemidplus]
synonym: "N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide" RELATED [chemidplus]
synonym: "N(1)-(3,4-dimethyl-5-isoxazolyl)sulfanilamide" RELATED [chemidplus]
synonym: "N(1)-(3,4-dimethyl-5-isoxazolyl)sulphanilamide" RELATED [chemidplus]
synonym: "Sulfadimethylisoxazole" RELATED [drugbank]
synonym: "Sulfafurazol" RELATED [drugbank]
synonym: "Sulfaisoxazole" RELATED [drugbank]
synonym: "Sulfasoxazole" RELATED [drugbank]
synonym: "Sulfisonazole" RELATED [drugbank]
synonym: "Sulfisoxasole" RELATED [drugbank]
synonym: "Sulfisoxazol" RELATED [drugbank]
synonym: "Sulfofurazole" RELATED [drugbank]
synonym: "Sulphadimethylisoxazole" RELATED [nist]
synonym: "Sulphafurazol" RELATED [drugbank]
synonym: "Sulphafurazole" RELATED [drugbank]
synonym: "Sulphaisoxazole" RELATED [drugbank]
synonym: "Sulphisoxazol" RELATED [drugbank]
synonym: "Sulphofurazole" RELATED [drugbank]
is_a: CHEBI:55373 ! isoxazoles
is_a: CHEBI:87228 ! sulfonamide antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
relationship: RO:0018038 CHEBI:45373 ! sulfanilamide

[Term]
id: CHEBI:10545
name: electron
namespace: chebi_ontology
def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." []
subset: 3:STAR
subset: 3_STAR
synonym: "beta" RELATED [iupac]
synonym: "beta" RELATED [IUPAC]
synonym: "beta(-)" RELATED [chebi]
synonym: "beta(-)" RELATED [ChEBI]
synonym: "beta-particle" RELATED [iupac]
synonym: "beta-particle" RELATED [IUPAC]
synonym: "e" RELATED [IUPAC]
synonym: "e" RELATED [iupac]
synonym: "e(-)" RELATED [UniProt]
synonym: "e(-)" RELATED [uniprot_ft]
synonym: "e-" RELATED [kegg.compound]
synonym: "e-" RELATED [KEGG_COMPOUND]
synonym: "electron" EXACT [ChEBI, KEGG_COMPOUND]
synonym: "electron" RELATED [chebi, kegg.compound]
synonym: "Elektron" RELATED [ChEBI]
synonym: "Elektron" RELATED [chebi]
synonym: "negatron" RELATED [iupac]
synonym: "negatron" RELATED [IUPAC]
xref: KEGG:C05359
xref: Wikipedia:Electron
is_a: CHEBI:36338 ! lepton

[Term]
id: CHEBI:10642
name: scyllo-inositol
namespace: chebi_ontology
alt_id: CHEBI:26614
subset: 3:STAR
synonym: "(1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexol" RELATED [iupac]
synonym: "1,3,5/2,4,6-cyclohexanehexol" RELATED [iupac]
synonym: "Cocositol" RELATED [nist]
synonym: "Quercinitol" RELATED [chemidplus]
synonym: "Scyllitol" RELATED [chemidplus]
synonym: "scyllo-Inositol" RELATED [kegg.compound]
synonym: "scyllo-inositol" RELATED [uniprot_ft]
is_a: CHEBI:24848 ! inositol
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:130181
name: calmodulin antagonist
namespace: chebi_ontology
def: "An antagonist that interferes with the action of the calcium-binding messenger protein calmodulin." []
subset: 3:STAR
is_a: CHEBI:48706 ! antagonist

[Term]
id: CHEBI:131604
name: Mycoplasma genitalium metabolite
namespace: chebi_ontology
def: "Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>." []
subset: 3:STAR
synonym: "Mycoplasma genitalium metabolites" RELATED [chebi]
is_a: CHEBI:76969 ! bacterial metabolite

[Term]
id: CHEBI:131605
name: dicarboxylic acid monoester(1-)
namespace: chebi_ontology
def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a dicarboxylic acid monoester." []
subset: 3:STAR
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:36244 ! dicarboxylic acid monoester

[Term]
id: CHEBI:131609
name: pneumocandin B0
namespace: chebi_ontology
def: "An echinocandin initially isolated as a very minor bioactive fermentation product of <em>Glarea lozoyensis</em> (originally known as <em>Zalerion arboricola</em>). Subsequent random mutagenesis work and optimisation of the fermentation medium permitted the industrial production of pneumocandin B<small><sub>0</sub></small>, which is used as the starting point for the synthesis of the antifungal drug caspofungin." []
subset: 3:STAR
synonym: "L 688,786" RELATED [chemidplus]
synonym: "L-688,786" RELATED [chemidplus]
synonym: "L-688786" RELATED [chemidplus]
synonym: "pneumocandin B(0)" RELATED [chemidplus]
synonym: "pneumocardin B(0)" RELATED [chemidplus]
is_a: CHEBI:24613 ! homodetic cyclic peptide
is_a: CHEBI:57248 ! echinocandin
relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite

[Term]
id: CHEBI:131871
name: hydroxy polyunsaturated fatty acid anion
namespace: chebi_ontology
def: "Any polyunsaturated fatty acid anion carrying one or more hydroxy substituents." []
subset: 3:STAR
synonym: "a hydroxy polyunsaturated fatty acid" RELATED [uniprot_ft]
synonym: "hydroxy polyunsaturated fatty acid anions" RELATED [chebi]
synonym: "hydroxy PUFA" RELATED [submitter]
is_a: CHEBI:59835 ! hydroxy fatty acid anion
is_a: CHEBI:76567 ! polyunsaturated fatty acid anion
relationship: RO:0018033 CHEBI:140345 ! hydroxy polyunsaturated fatty acid

[Term]
id: CHEBI:131927
name: dicarboxylic acids and O-substituted derivatives
namespace: chebi_ontology
def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." []
subset: 3:STAR
synonym: "dicarboxylic acids and derivatives" RELATED [chebi]
is_a: CHEBI:36586 ! carbonyl compound

[Term]
id: CHEBI:132130
name: hydroxyquinone
namespace: chebi_ontology
def: "Any quinone in which one or more of the carbons making up the quinone moiety is substituted by a hydroxy group." []
subset: 3:STAR
synonym: "hydroxyquinones" RELATED [chebi]
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:36141 ! quinone

[Term]
id: CHEBI:132142
name: 1,4-naphthoquinones
namespace: chebi_ontology
def: "A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring." []
subset: 3:STAR
is_a: CHEBI:25481 ! naphthoquinone
is_a: CHEBI:25830 ! p-quinones

[Term]
id: CHEBI:132155
name: hydroxynaphthoquinone
namespace: chebi_ontology
def: "Any naphthoquinone in which the naphthaoquinone moiety is substituted by at least one hydroxy group." []
subset: 3:STAR
synonym: "hydroxynaphthoquinones" RELATED [chebi]
is_a: CHEBI:132130 ! hydroxyquinone
is_a: CHEBI:25481 ! naphthoquinone

[Term]
id: CHEBI:132157
name: hydroxy-1,4-naphthoquinone
namespace: chebi_ontology
def: "Any member of the class of 1,4-naphthoquinones in which the naphthoquinone moiety is substituted by at least one hydroxy group." []
subset: 3:STAR
synonym: "hydroxy-1,4-naphthoquinones" RELATED [chebi]
is_a: CHEBI:132142 ! 1,4-naphthoquinones
is_a: CHEBI:132155 ! hydroxynaphthoquinone

[Term]
id: CHEBI:13248
name: anilide
namespace: chebi_ontology
def: "Any aromatic amide obtained by acylation of aniline." []
subset: 3:STAR
synonym: "an anilide" RELATED [uniprot_ft]
synonym: "N-phenyl amide" RELATED [chebi]
synonym: "N-phenyl amides" RELATED [chebi]
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:62733 ! aromatic amide
relationship: RO:0018038 CHEBI:17296 ! aniline

[Term]
id: CHEBI:132717
name: bleaching agent
namespace: chebi_ontology
def: "A reagent that lightens or whitens a substrate through chemical reaction. Bleaching reactions usually involve oxidative or reductive processes that degrade colour systems. Bleaching can occur by destroying one or more of the double bonds in the conjugated chain, by cleaving the conjugated chain, or by oxidation of one of the other moieties in the conjugated chain. Their reactivity results in many bleaches having strong bactericidal, disinfecting, and sterilising properties." []
subset: 3:STAR
is_a: CHEBI:33893 ! reagent

[Term]
id: CHEBI:133011
name: oxytetracycline zwitterion
namespace: chebi_ontology
def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the adjacent tertiary amino group of oxytetracycline; major species at pH 7.3." []
subset: 3:STAR
synonym: "oxytetracycline" RELATED [uniprot_ft]
is_a: CHEBI:144644 ! a tetracycline zwitterion
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:27701 ! oxytetracycline

[Term]
id: CHEBI:133135
name: chromenochromene
namespace: chebi_ontology
def: "Any organic heteroolycyclic compound whose skeleton two <em>ortho</em>-fused chromene rings, and their derivatives." []
subset: 3:STAR
synonym: "chromenochromenes" RELATED [chebi]
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:133598
name: chlortetracycline(1-)
namespace: chebi_ontology
def: "An organic anion that is the major structure of chlortetracycline at pH 7.3 (according to Marvin v 6.2.0.)." []
subset: 3:STAR
synonym: "7-chlorotetracycline" RELATED [uniprot_ft]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0018033 CHEBI:27644 ! chlortetracycline

[Term]
id: CHEBI:133833
name: benznidazole
namespace: chebi_ontology
def: "A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease." []
subset: 3:STAR
synonym: "2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide" RELATED [chemidplus]
synonym: "N-Benzyl-2-nitroimidazol-1-yl-acetamide" RELATED [chemidplus]
synonym: "N-Benzyl-2-nitroimidazole-1-acetamide" RELATED [chemidplus]
is_a: CHEBI:24780 ! imidazoles
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:35716 ! C-nitro compound
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug

[Term]
id: CHEBI:134179
name: volatile organic compound
namespace: chebi_ontology
def: "Any organic compound having an initial boiling point less than or equal to 250 °C (482 °F) measured at a standard atmospheric pressure of 101.3 kPa." []
subset: 3:STAR
synonym: "VOC" RELATED [chebi]
synonym: "VOCs" RELATED [chebi]
synonym: "volatile organic compounds" RELATED [chebi]
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:135928
name: doripenem
namespace: chebi_ontology
subset: 2:STAR
synonym: "doribax" RELATED [drugcentral]
synonym: "doripenem hydrate" RELATED [drugcentral]
is_a: CHEBI:46633 ! carbapenems

[Term]
id: CHEBI:13643
name: glycol
namespace: chebi_ontology
def: "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." []
subset: 3:STAR
synonym: "Glykol" RELATED [chebi]
is_a: CHEBI:23824 ! diol

[Term]
id: CHEBI:136622
name: aci-nitro compound
namespace: chebi_ontology
def: "Organonitrogen compounds that have the general structure R<small><sup>1</small></sup>(R<small><sup>2</small></sup>)C=N(O)OH (R<small><sup>1</small></sup>,R<small><sup>2</small></sup> = H, organyl). They are tautomers of <em>C</em>-nitro compounds." []
subset: 3:STAR
synonym: "aci-nitro compounds" RELATED [chebi]
synonym: "oxime N-oxide" RELATED [chebi]
synonym: "oxime N-oxides" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0018036 CHEBI:35716 ! C-nitro compound
relationship: RO:0018038 CHEBI:25750 ! oxime

[Term]
id: CHEBI:136651
name: S100 calcium-binding protein B inhibitor
namespace: chebi_ontology
def: "Any inhibitor of S100 calcium-binding protein B." []
subset: 3:STAR
synonym: "S100 calcium-binding protein B inhibitors" RELATED [chebi]
synonym: "S100B inhibitor" RELATED [chebi]
synonym: "S100B inhibitors" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:136859
name: pro-agent
namespace: chebi_ontology
def: "A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent." []
subset: 3:STAR
synonym: "pro-agents" RELATED [chebi]
synonym: "proagent" RELATED [chebi]
synonym: "proagents" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:137419
name: secondary ammonium ion
namespace: chebi_ontology
def: "An organic cation obtained by protonation of any secondary amino compound; major species at pH 7.3." []
subset: 3:STAR
synonym: "a secondary amine" RELATED [uniprot_ft]
synonym: "secondary amine(1+)" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:32863 ! secondary amine

[Term]
id: CHEBI:137598
name: 4-aminosalicylate(1-)
namespace: chebi_ontology
def: "An aminobenzoate that is the conjugate base of 4-aminosalicylic acid, obtained by deprotonation of the carboxy group. Major miscrospecies at pH 7.3." []
subset: 3:STAR
synonym: "4-aminosalicylate" RELATED [uniprot_ft]
is_a: CHEBI:22494 ! aminobenzoate
is_a: CHEBI:24675 ! hydroxybenzoate
relationship: RO:0018033 CHEBI:27565 ! 4-aminosalicylic acid
relationship: RO:0018038 CHEBI:30762 ! salicylate

[Term]
id: CHEBI:137982
name: tertiary ammonium ion
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the amino group of any tertiary amino compound." []
subset: 3:STAR
synonym: "a tertiary amine" RELATED [uniprot_ft]
synonym: "tertiary amine(1+)" RELATED [chebi]
synonym: "tertiary ammonium ions" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
relationship: RO:0018034 CHEBI:50996 ! tertiary amino compound

[Term]
id: CHEBI:138015
name: endocrine disruptor
namespace: chebi_ontology
def: "Any compound that can disrupt the functions of the endocrine (hormone) system" []
subset: 3:STAR
synonym: "endocrine disrupting chemical" RELATED [chebi]
synonym: "endocrine disrupting chemicals" RELATED [chebi]
synonym: "endocrine disrupting compound" RELATED [chebi]
synonym: "endocrine disrupting compounds" RELATED [chebi]
synonym: "endocrine disruptors" RELATED [chebi]
synonym: "endocrine-disrupting chemical" RELATED [chebi]
synonym: "endocrine-disrupting chemicals" RELATED [chebi]
synonym: "hormonally active agent" RELATED [chebi]
synonym: "hormonally active agents" RELATED [chebi]
is_a: CHEBI:51061 ! hormone receptor modulator

[Term]
id: CHEBI:138103
name: inorganic acid
namespace: chebi_ontology
def: "A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." []
subset: 3:STAR
synonym: "inorganic acids" RELATED [chebi]
synonym: "mineral acid" RELATED [chebi]
synonym: "mineral acids" RELATED [chebi]
is_a: CHEBI:39141 ! Bronsted acid

[Term]
id: CHEBI:138675
name: gas molecular entity
namespace: chebi_ontology
def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." []
subset: 3:STAR
subset: 3_STAR
synonym: "gas molecular entities" RELATED [chebi]
synonym: "gas molecular entities" RELATED [ChEBI]
synonym: "gaseous molecular entities" RELATED [chebi]
synonym: "gaseous molecular entities" RELATED [ChEBI]
synonym: "gaseous molecular entity" RELATED [ChEBI]
synonym: "gaseous molecular entity" RELATED [chebi]
xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas
is_a: CHEBI:33579 ! main group molecular entity

[Term]
id: CHEBI:138856
name: oxolinic acid
namespace: chebi_ontology
alt_id: CHEBI:44731
alt_id: CHEBI:7848
def: "A quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the treatment of bacterial infections in cattle, pigs and poultry." []
subset: 3:STAR
synonym: "1-Ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid" RELATED [chemidplus]
synonym: "1-Ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid" RELATED [chemidplus]
synonym: "5-Ethyl-5,8-dihydro-8-oxo-1,3-dioxolo(4,5-g)quinoline-7-carboxylic acid" RELATED [chemidplus]
synonym: "OA" RELATED [kegg.drug]
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:86324 ! quinolone antibiotic
relationship: RO:0000087 CHEBI:23924 ! has role enzyme inhibitor
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:59066 ! oxolinate

[Term]
id: CHEBI:13941
name: carbamate
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "Carbamat" RELATED [chebi]
synonym: "Carbamat" RELATED [ChEBI]
synonym: "carbamate" EXACT [UniProt]
synonym: "carbamate" RELATED [uniprot_ft]
synonym: "carbamate ion" RELATED [ChemIDplus]
synonym: "carbamate ion" RELATED [chemidplus]
synonym: "carbamic acid, ion(1-)" RELATED [chemidplus]
synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus]
synonym: "Karbamat" RELATED [ChEBI]
synonym: "Karbamat" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid
relationship: RO:0018033 CHEBI:28616 ! carbamic acid

[Term]
id: CHEBI:139492
name: sensitiser
namespace: chebi_ontology
def: "A chemical compound that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the compound." []
subset: 3:STAR
synonym: "sensitisers" RELATED [chebi]
synonym: "sensitizer" RELATED [chebi]
synonym: "sensitizers" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:139512
name: EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor
namespace: chebi_ontology
def: "An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of enoyl-[acyl-carrier-protein] reductase (NADH), EC 1.3.1.9." []
subset: 3:STAR
synonym: "acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitor" RELATED [chebi]
synonym: "acyl-[acyl-carrier-protein]:NAD+ oxidoreductase inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.9 inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.9 inhibitors" RELATED [chebi]
synonym: "enoyl-[acyl carrier protein] reductase inhibitor" RELATED [chebi]
synonym: "enoyl-[acyl carrier protein] reductase inhibitors" RELATED [chebi]
synonym: "enoyl-ACP reductase inhibitor" RELATED [chebi]
synonym: "enoyl-ACP reductase inhibitors" RELATED [chebi]
synonym: "ENR inhibitor" RELATED [chebi]
synonym: "ENR inhibitors" RELATED [chebi]
synonym: "NADH-enoyl acyl carrier protein reductase inhibitor" RELATED [chebi]
synonym: "NADH-enoyl acyl carrier protein reductase inhibitors" RELATED [chebi]
synonym: "NADH-specific enoyl-ACP reductase inhibitor" RELATED [chebi]
synonym: "NADH-specific enoyl-ACP reductase inhibitors" RELATED [chebi]
is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor

[Term]
id: CHEBI:139588
name: alpha-hydroxy ketone
namespace: chebi_ontology
def: "A ketone containing a hydroxy group on the α-carbon relative to the C=O group." []
subset: 3:STAR
synonym: "alpha-hydroxy ketones" RELATED [chebi]
synonym: "alpha-hydroxy-ketone" RELATED [chebi]
synonym: "alpha-hydroxy-ketones" RELATED [chebi]
synonym: "alpha-hydroxyketone" RELATED [chebi]
synonym: "alpha-hydroxyketones" RELATED [chebi]
is_a: CHEBI:17087 ! ketone
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:139592
name: tertiary alpha-hydroxy ketone
namespace: chebi_ontology
def: "An α-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups." []
subset: 3:STAR
synonym: "tertiary alpha-hydroxy ketones" RELATED [chebi]
synonym: "tertiary alpha-hydroxy-ketone" RELATED [chebi]
synonym: "tertiary alpha-hydroxy-ketones" RELATED [chebi]
synonym: "tertiary alpha-hydroxyketone" RELATED [chebi]
synonym: "tertiary alpha-hydroxyketones" RELATED [chebi]
is_a: CHEBI:139588 ! alpha-hydroxy ketone
is_a: CHEBI:26878 ! tertiary alcohol

[Term]
id: CHEBI:140190
name: calcium-dependent antibiotics
namespace: chebi_ontology
def: "Any antimicrobial agent whose activity is dependent on the presence of calcium ions." []
subset: 3:STAR
synonym: "Ca(2+)-dependent antibiotic" RELATED [chebi]
synonym: "Ca(2+)-dependent antibiotics" RELATED [chebi]
synonym: "Ca-dependent antibiotic" RELATED [chebi]
synonym: "Ca-dependent antibiotics" RELATED [chebi]
synonym: "calcium-dependent antibiotic" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:140325
name: secondary carboxamide
namespace: chebi_ontology
def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR<small><sup>1</small></sup>." []
subset: 3:STAR
synonym: "secondary carboxamides" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:140326
name: tertiary carboxamide
namespace: chebi_ontology
def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR<small><sup>1</small></sup>R<small><sup>2</small></sup>." []
subset: 3:STAR
synonym: "tertiary carboxamides" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:140345
name: hydroxy polyunsaturated fatty acid
namespace: chebi_ontology
def: "Any polyunsaturated fatty acid carrying one or more hydroxy substituents." []
subset: 3:STAR
is_a: CHEBI:24654 ! hydroxy fatty acid
is_a: CHEBI:26208 ! polyunsaturated fatty acid
relationship: RO:0018034 CHEBI:131871 ! hydroxy polyunsaturated fatty acid anion

[Term]
id: CHEBI:140921
name: Hedgehog signaling pathway inhibitor
namespace: chebi_ontology
def: "Any pathway inhibitor that inhibits the Hedgehog signalling pathway." []
subset: 3:STAR
synonym: "Hedgehog pathway inhibitor" RELATED [chebi]
synonym: "Hedgehog pathway inhibitors" RELATED [chebi]
synonym: "Hedgehog signaling pathway inhibitors" RELATED [chebi]
is_a: CHEBI:76932 ! pathway inhibitor

[Term]
id: CHEBI:140922
name: glioma-associated oncogene inhibitor
namespace: chebi_ontology
def: "An inhibitor of any of the glioma-associated oncogene (GLI) proteins." []
subset: 3:STAR
synonym: "GLI inhibitor" RELATED [chebi]
synonym: "GLI inhibitors" RELATED [chebi]
synonym: "glioma-associated oncogene inhibitors" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor

[Term]
id: CHEBI:141153
name: quinone outside inhibitor
namespace: chebi_ontology
def: "A mitochondrial cytochrome-<em>b</em><em>c</em><small><sub>1</sub></small> complex inhibitor that acts at the Quinone 'outer' (Q<small><sub>o</sub></small>) binding site of the cytochrome-<em>b</em><em>c</em><small><sub>1</sub></small> complex." []
subset: 3:STAR
synonym: "Qo inhibitor" RELATED [chebi]
synonym: "Qo inhibitors" RELATED [chebi]
synonym: "QOI" RELATED [chebi]
synonym: "QOIs" RELATED [chebi]
synonym: "quinone outside inhibitors" RELATED [chebi]
is_a: CHEBI:24127 ! fungicide
is_a: CHEBI:38499 ! mitochondrial cytochrome-bc1 complex inhibitor

[Term]
id: CHEBI:141498
name: hemiaminal ether
namespace: chebi_ontology
def: "An organic amino compound that is a hemiaminal in which the hydrogen atom of the hydroxy group has been replaced by an organyl group. General formula: R2C(OR')NR2 ( R ≠ H ). Also known as α-amino ethers." []
subset: 3:STAR
synonym: "alpha-amino ether" RELATED [chebi]
synonym: "alpha-amino ethers" RELATED [chebi]
synonym: "hemiaminal ethers" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound
is_a: CHEBI:50047 ! organic amino compound
relationship: RO:0018038 CHEBI:73080 ! hemiaminal

[Term]
id: CHEBI:142513
name: oxime anion
namespace: chebi_ontology
def: "A organic ion resulting from the deprotonation of the hydroxy group of any oxime." []
subset: 3:STAR
synonym: "oximate" RELATED [chebi]
synonym: "oximates" RELATED [chebi]
synonym: "oxime anion" RELATED [chebi]
synonym: "oxime anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0018033 CHEBI:25750 ! oxime

[Term]
id: CHEBI:142708
name: tigecycline(1+)
namespace: chebi_ontology
def: "An ammonium ion that is the conjugate acid of tigecycline; major species at pH 7.3." []
subset: 3:STAR
synonym: "tigecycline" RELATED [uniprot_ft]
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:149836 ! tigecycline

[Term]
id: CHEBI:144644
name: a tetracycline zwitterion
namespace: chebi_ontology
subset: 2:STAR
synonym: "a tetracycline" RELATED [uniprot_ft]
is_a: CHEBI:26895 ! tetracyclines

[Term]
id: CHEBI:145555
name: macropolylide
namespace: chebi_ontology
def: "Macrolides (macrocyclic lactones) in which the macrocyclic ring contains more than one ester linkage. Macropolylides include macrodiolides, macrotriolides, macrotetrolides and macropentolides, each containing di-, tri-, tetra-, and penta- ester linkages, respectively, in one macrocyclic ring. Macrocyclic lactones containing nitrogen in their skeletons (azamacrolides and macrolide lactams) and also containing oxazole or thiazole in their skeletons are known in nature." []
subset: 3:STAR
synonym: "macropolylides" RELATED [chebi]
is_a: CHEBI:25106 ! macrolide

[Term]
id: CHEBI:145556
name: macrodiolide
namespace: chebi_ontology
def: "A macropolylide which contains two ester linkages in one macrocyclic ring." []
subset: 3:STAR
synonym: "macrodiolides" RELATED [chebi]
is_a: CHEBI:145555 ! macropolylide

[Term]
id: CHEBI:145565
name: macrolide lactam
namespace: chebi_ontology
def: "A macrolide in which the macrocyclic lactone ring includes an amide group." []
subset: 3:STAR
synonym: "macrolide lactams" RELATED [chebi]
is_a: CHEBI:24995 ! lactam
is_a: CHEBI:25106 ! macrolide

[Term]
id: CHEBI:145790
name: mupirocin(1-)
namespace: chebi_ontology
def: "A monocarboxylic acid anion that is the conjugate base of mupirocin obtained by the deprotonation of the carboxy group; major microspecies at pH 7.3." []
subset: 3:STAR
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:7025 ! mupirocin

[Term]
id: CHEBI:146260
name: spectinomycin(1+)
namespace: chebi_ontology
def: "A secondary ammonium ion derived from spectinomycin by protonation of the secondary amino group located between the two alcoholic hydroxy groups." []
subset: 3:STAR
synonym: "spectinomycin" RELATED [uniprot_ft]
is_a: CHEBI:137419 ! secondary ammonium ion
relationship: RO:0018033 CHEBI:77315 ! spectinomycin(2+)
relationship: RO:0018034 CHEBI:9215 ! spectinomycin

[Term]
id: CHEBI:146295
name: pyranobenzodioxin
namespace: chebi_ontology
def: "Any organic heterotricyclic compound whose core skeleton consists of a benzodioxin ring that is ortho-fused to a pyran ring." []
subset: 3:STAR
synonym: "pyranobenzodioxins" RELATED [chebi]
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:149552
name: emetic
namespace: chebi_ontology
def: "Any agent that induces nausea and vomiting." []
subset: 3:STAR
synonym: "emetics" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:149553
name: anticoronaviral agent
namespace: chebi_ontology
def: "Any antiviral agent which inhibits the activity of coronaviruses." []
subset: 3:STAR
synonym: "anti-coronaviral agent" RELATED [chebi]
synonym: "anti-coronaviral agents" RELATED [chebi]
synonym: "anti-coronavirus agent" RELATED [chebi]
synonym: "anti-coronavirus agents" RELATED [chebi]
synonym: "anticoronaviral agent" RELATED [chebi]
synonym: "anticoronaviral agents" RELATED [chebi]
synonym: "anticoronaviral drug" RELATED [chebi]
synonym: "anticoronaviral drugs" RELATED [chebi]
synonym: "anticoronavirus agent" RELATED [chebi]
synonym: "anticoronavirus agents" RELATED [chebi]
synonym: "anticoronviral agent" RELATED [chebi]
synonym: "anticoronviral agents" RELATED [chebi]
is_a: CHEBI:22587 ! antiviral agent

[Term]
id: CHEBI:149836
name: tigecycline
namespace: chebi_ontology
alt_id: CHEBI:29696
alt_id: CHEBI:473970
def: "Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (<em>N</em>-<em>tert</em>-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms." []
subset: 3:STAR
synonym: "(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide" RELATED [chemidplus]
is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone
is_a: CHEBI:26895 ! tetracyclines
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018033 CHEBI:142708 ! tigecycline(1+)

[Term]
id: CHEBI:15022
name: electron donor
namespace: chebi_ontology
def: "A molecular entity that can transfer an electron to another molecular entity." []
subset: 3:STAR
synonym: "donneur d'electron" RELATED [iupac]
synonym: "Elektronendonator" RELATED [chebi]
is_a: CHEBI:17891 ! donor

[Term]
id: CHEBI:15138
name: sulfide(2-)
namespace: chebi_ontology
def: "A divalent inorganic anion obtained by removal of both protons from hydrogen sulfide." []
subset: 3:STAR
synonym: "S(2-)" RELATED [iupac]
synonym: "Sulfide" RELATED [chemidplus]
synonym: "sulphide" RELATED [chebi]
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0018033 CHEBI:29919 ! hydrosulfide

[Term]
id: CHEBI:15339
name: acceptor
namespace: chebi_ontology
alt_id: CHEBI:13699
alt_id: CHEBI:2377
def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." []
subset: 3:STAR
subset: 3_STAR
synonym: "A" RELATED [kegg.compound]
synonym: "A" RELATED [KEGG_COMPOUND]
synonym: "accepteur" RELATED [ChEBI]
synonym: "accepteur" RELATED [chebi]
synonym: "Acceptor" EXACT [KEGG_COMPOUND]
synonym: "Acceptor" RELATED [kegg.compound]
synonym: "Akzeptor" RELATED [chebi]
synonym: "Akzeptor" RELATED [ChEBI]
synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND]
synonym: "Hydrogen-acceptor" RELATED [kegg.compound]
synonym: "Oxidized donor" RELATED [kegg.compound]
synonym: "Oxidized donor" RELATED [KEGG_COMPOUND]
xref: KEGG:C00028
xref: KEGG:C16722
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:15354
name: choline
namespace: chebi_ontology
alt_id: CHEBI:13985
alt_id: CHEBI:23212
alt_id: CHEBI:3665
alt_id: CHEBI:41524
def: "A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function." []
subset: 3:STAR
synonym: "Bilineurine" RELATED [kegg.compound]
synonym: "Choline" RELATED [kegg.compound]
synonym: "choline" RELATED [uniprot_ft]
synonym: "CHOLINE ION" RELATED [pdb-ccd]
synonym: "N,N,N-trimethylethanol-ammonium" RELATED [chebi]
synonym: "N-trimethylethanolamine" RELATED [chebi]
synonym: "trimethylethanolamine" RELATED [chebi]
is_a: CHEBI:23217 ! cholines
relationship: RO:0000087 CHEBI:25512 ! has role neurotransmitter
relationship: RO:0000087 CHEBI:33284 ! has role nutrient
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite

[Term]
id: CHEBI:15366
name: acetic acid
namespace: chebi_ontology
alt_id: CHEBI:22169
alt_id: CHEBI:2387
alt_id: CHEBI:40486
def: "A simple monocarboxylic acid containing two carbons." []
subset: 3:STAR
synonym: "ACETIC ACID" EXACT [PDBeChem]
synonym: "ACETIC ACID" RELATED [pdb-ccd]
synonym: "Acetic acid" EXACT [KEGG_COMPOUND]
synonym: "Acetic acid" RELATED [kegg.compound]
synonym: "acide acetique" RELATED [chemidplus]
synonym: "AcOH" RELATED [chebi]
synonym: "CH3-COOH" RELATED [iupac]
synonym: "CH3CO2H" RELATED [chebi]
synonym: "E 260" RELATED [chebi]
synonym: "E-260" RELATED [chebi]
synonym: "E260" RELATED [chebi]
synonym: "Essigsaeure" RELATED [chebi]
synonym: "Ethanoic acid" RELATED [kegg.compound]
synonym: "ethoic acid" RELATED [chebi]
synonym: "Ethylic acid" RELATED [chemidplus]
synonym: "HOAc" RELATED [chebi]
synonym: "INS No. 260" RELATED [chebi]
synonym: "MeCO2H" RELATED [chebi]
synonym: "MeCOOH" RELATED [chebi]
synonym: "Methanecarboxylic acid" RELATED [chemidplus]
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
relationship: RO:0000087 CHEBI:64049 ! has role food acidity regulator
relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018034 CHEBI:30089 ! acetate

[Term]
id: CHEBI:15369
name: actinomycin
namespace: chebi_ontology
alt_id: CHEBI:13723
alt_id: CHEBI:22220
alt_id: CHEBI:2445
def: "A large group of antibiotics isolated from various species of <em>Streptomyces</em> and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides." []
subset: 3:STAR
synonym: "Actinomycin" RELATED [kegg.compound]
synonym: "actinomycins" RELATED [chebi]
is_a: CHEBI:23239 ! chromopeptide

[Term]
id: CHEBI:15693
name: aldose
namespace: chebi_ontology
alt_id: CHEBI:13755
alt_id: CHEBI:22305
alt_id: CHEBI:2561
def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals." []
subset: 3:STAR
synonym: "Aldose" RELATED [kegg.compound]
synonym: "aldoses" RELATED [chebi]
synonym: "an aldose" RELATED [uniprot_ft]
is_a: CHEBI:35381 ! monosaccharide

[Term]
id: CHEBI:15705
name: L-alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:13072
alt_id: CHEBI:13243
alt_id: CHEBI:13797
alt_id: CHEBI:21224
alt_id: CHEBI:6175
def: "Any α-amino acid having <small>L</small>-configuration at the α-carbon." []
subset: 3:STAR
synonym: "L-2-Amino acid" RELATED [kegg.compound]
synonym: "L-alpha-amino acid" RELATED [iupac]
synonym: "L-alpha-amino acids" RELATED [chebi]
synonym: "L-Amino acid" RELATED [kegg.compound]
is_a: CHEBI:33704 ! alpha-amino acid
relationship: RO:0018034 CHEBI:59814 ! L-alpha-amino acid anion
relationship: RO:0018036 CHEBI:59869 ! L-alpha-amino acid zwitterion

[Term]
id: CHEBI:15734
name: primary alcohol
namespace: chebi_ontology
alt_id: CHEBI:13676
alt_id: CHEBI:14887
alt_id: CHEBI:26262
alt_id: CHEBI:57489
alt_id: CHEBI:8406
def: "A primary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." []
subset: 3:STAR
synonym: "1-Alcohol" RELATED [kegg.compound]
synonym: "a primary alcohol" RELATED [uniprot_ft]
synonym: "Primary alcohol" RELATED [kegg.compound]
synonym: "primary alcohols" RELATED [chebi]
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:15740
name: formate
namespace: chebi_ontology
alt_id: CHEBI:14276
alt_id: CHEBI:24081
def: "A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects." []
subset: 3:STAR
synonym: "aminate" RELATED [chebi]
synonym: "formate" RELATED [uniprot_ft]
synonym: "formiate" RELATED [chebi]
synonym: "formic acid, ion(1-)" RELATED [chemidplus]
synonym: "formylate" RELATED [chebi]
synonym: "HCO2 anion" RELATED [nist]
synonym: "hydrogen carboxylate" RELATED [chebi]
synonym: "methanoate" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:30751 ! formic acid

[Term]
id: CHEBI:15841
name: polypeptide
namespace: chebi_ontology
alt_id: CHEBI:14860
alt_id: CHEBI:8314
def: "A peptide containing ten or more amino acid residues." []
subset: 3:STAR
subset: 3_STAR
synonym: "polipeptido" RELATED [chebi]
synonym: "polipeptido" RELATED [ChEBI]
synonym: "Polypeptid" RELATED [chebi]
synonym: "Polypeptid" RELATED [ChEBI]
synonym: "Polypeptide" EXACT [KEGG_COMPOUND]
synonym: "Polypeptide" RELATED [kegg.compound]
xref: KEGG:C00403
is_a: CHEBI:16670 ! peptide
is_a: CHEBI:33839 ! macromolecule

[Term]
id: CHEBI:15940
name: nicotinic acid
namespace: chebi_ontology
alt_id: CHEBI:25538
alt_id: CHEBI:44319
alt_id: CHEBI:7559
def: "A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group." []
subset: 3:STAR
synonym: "3-carboxylpyridine" RELATED [chemidplus]
synonym: "3-carboxypyridine" RELATED [nist]
synonym: "3-pyridinecarboxylic acid" RELATED [kegg.compound]
synonym: "3-Pyridylcarboxylic acid" RELATED [hmdb]
synonym: "anti-pellagra vitamin" RELATED [nist]
synonym: "beta-pyridinecarboxylic acid" RELATED [chebi]
synonym: "m-pyridinecarboxylic acid" RELATED [nist]
synonym: "Niacin" RELATED [kegg.compound]
synonym: "NICOTINIC ACID" EXACT [PDBeChem]
synonym: "NICOTINIC ACID" RELATED [pdb-ccd]
synonym: "Nicotinic acid" EXACT [KEGG_COMPOUND]
synonym: "Nicotinic acid" RELATED [kegg.compound]
synonym: "Nicotinsaure" RELATED [chemidplus]
synonym: "Nikotinsaeure" RELATED [chebi]
synonym: "P.P. factor" RELATED [nist]
synonym: "pellagra preventive factor" RELATED [nist]
synonym: "PP factor" RELATED [nist]
synonym: "pyridine-beta-carboxylic acid" RELATED [nist]
synonym: "pyridine-carboxylique-3" RELATED [chemidplus]
synonym: "vitamin B3" RELATED [chebi]
is_a: CHEBI:176839 ! vitamin B3
is_a: CHEBI:26416 ! pyridine alkaloid
is_a: CHEBI:26420 ! pyridinemonocarboxylic acid
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:35679 ! has role antilipemic drug
relationship: RO:0000087 CHEBI:50247 ! has role antidote
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite
relationship: RO:0000087 CHEBI:84264 ! has role EC 3.5.1.19 (nicotinamidase) inhibitor
relationship: RO:0018034 CHEBI:32544 ! nicotinate

[Term]
id: CHEBI:15986
name: polynucleotide
namespace: chebi_ontology
alt_id: CHEBI:13672
alt_id: CHEBI:14859
alt_id: CHEBI:8312
def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." []
subset: 3:STAR
subset: 3_STAR
synonym: "Polynucleotide" EXACT [KEGG_COMPOUND]
synonym: "Polynucleotide" RELATED [kegg.compound]
synonym: "polynucleotides" RELATED [chebi]
synonym: "polynucleotides" RELATED [ChEBI]
xref: KEGG:C00419
is_a: CHEBI:33695 ! information biomacromolecule
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: BFO:0000051 CHEBI:50319 ! has part nucleotide residue

[Term]
id: CHEBI:16040
name: cytosine
namespace: chebi_ontology
alt_id: CHEBI:14066
alt_id: CHEBI:23531
alt_id: CHEBI:4072
alt_id: CHEBI:41732
def: "An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4." []
subset: 3:STAR
synonym: "4-amino-2(1H)-pyrimidinone" RELATED [nist]
synonym: "4-amino-2-hydroxypyrimidine" RELATED [nist]
synonym: "C" RELATED [chebi]
synonym: "Cyt" RELATED [iubmb]
synonym: "Cytosin" RELATED [chebi]
synonym: "Cytosine" RELATED [kegg.compound]
synonym: "cytosine" RELATED [uniprot_ft]
synonym: "Zytosin" RELATED [chebi]
is_a: CHEBI:26432 ! pyrimidine nucleobase
is_a: CHEBI:38337 ! pyrimidone
is_a: CHEBI:38338 ! aminopyrimidine
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:16042
name: halide anion
namespace: chebi_ontology
alt_id: CHEBI:14384
alt_id: CHEBI:5605
def: "A monoatomic monoanion resulting from the addition of an electron to any halogen atom." []
subset: 3:STAR
synonym: "a halide anion" RELATED [uniprot_ft]
synonym: "Halide" RELATED [kegg.compound]
synonym: "halide anions" RELATED [chebi]
synonym: "halide(1-)" RELATED [chebi]
synonym: "halides" RELATED [chebi]
synonym: "halogen anion" RELATED [chebi]
synonym: "HX" RELATED [kegg.compound]
is_a: CHEBI:33429 ! monoatomic monoanion
is_a: CHEBI:79389 ! monovalent inorganic anion

[Term]
id: CHEBI:16134
name: ammonia
namespace: chebi_ontology
alt_id: CHEBI:13405
alt_id: CHEBI:13406
alt_id: CHEBI:13407
alt_id: CHEBI:13771
alt_id: CHEBI:22533
alt_id: CHEBI:44269
alt_id: CHEBI:44284
alt_id: CHEBI:44404
alt_id: CHEBI:7434
def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." []
subset: 3:STAR
subset: 3_STAR
synonym: "[NH3]" RELATED [molbase]
synonym: "[NH3]" RELATED [MolBase]
synonym: "AMMONIA" EXACT [PDBeChem]
synonym: "AMMONIA" RELATED [pdb-ccd]
synonym: "Ammonia" EXACT [KEGG_COMPOUND]
synonym: "Ammonia" RELATED [kegg.compound]
synonym: "ammoniac" RELATED [ChEBI]
synonym: "ammoniac" RELATED [chebi]
synonym: "Ammoniak" RELATED [chemidplus]
synonym: "Ammoniak" RELATED [ChemIDplus]
synonym: "amoniaco" RELATED [chebi]
synonym: "amoniaco" RELATED [ChEBI]
synonym: "NH3" RELATED [IUPAC, KEGG_COMPOUND]
synonym: "NH3" RELATED [iupac, kegg.compound]
synonym: "R-717" RELATED [ChEBI]
synonym: "R-717" RELATED [chebi]
synonym: "spirit of hartshorn" RELATED [ChemIDplus]
synonym: "spirit of hartshorn" RELATED [chemidplus]
xref: HMDB:HMDB0000051
xref: KEGG:C00014
xref: KEGG:D02916
xref: KNApSAcK:C00007267
xref: MetaCyc:AMMONIA
xref: MolBase:930
xref: PDBeChem:NH3
xref: Wikipedia:Ammonia
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:35107 ! azane
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: is_conjugate_acid_of CHEBI:29337 ! azanide
relationship: is_conjugate_base_of CHEBI:28938 ! ammonium
relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:59740 ! has role nucleophilic reagent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77941 ! has role EC 3.5.1.4 (amidase) inhibitor
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
relationship: RO:0018033 CHEBI:28938 ! ammonium
relationship: RO:0018034 CHEBI:29337 ! azanide

[Term]
id: CHEBI:16136
name: hydrogen sulfide
namespace: chebi_ontology
alt_id: CHEBI:13356
alt_id: CHEBI:14414
alt_id: CHEBI:24639
alt_id: CHEBI:43058
alt_id: CHEBI:45489
alt_id: CHEBI:5787
def: "A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen." []
subset: 3:STAR
synonym: "[SH2]" RELATED [molbase]
synonym: "acide sulfhydrique" RELATED [chemidplus]
synonym: "dihydrogen monosulfide" RELATED [nist]
synonym: "dihydrogen sulfide" RELATED [nist]
synonym: "H2S" RELATED [iupac, kegg.compound]
synonym: "hydrogen monosulfide" RELATED [nist]
synonym: "Hydrogen sulfide" EXACT [KEGG_COMPOUND]
synonym: "Hydrogen sulfide" RELATED [kegg.compound]
synonym: "hydrogen sulphide" RELATED [chemidplus]
synonym: "Hydrogen-sulfide" RELATED [kegg.compound]
synonym: "hydrogene sulfure" RELATED [chemidplus]
synonym: "HYDROSULFURIC ACID" RELATED [pdb-ccd]
synonym: "Schwefelwasserstoff" RELATED [chemidplus]
synonym: "Sulfide" RELATED [kegg.compound]
synonym: "sulfure d'hydrogene" RELATED [chebi]
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:33405 ! hydracid
is_a: CHEBI:33535 ! sulfur hydride
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: RO:0000087 CHEBI:27026 ! has role toxin
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:50902 ! has role genotoxin
relationship: RO:0000087 CHEBI:62488 ! has role signalling molecule
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:30488 ! sulfonium
relationship: RO:0018034 CHEBI:29919 ! hydrosulfide

[Term]
id: CHEBI:16150
name: benzoate
namespace: chebi_ontology
alt_id: CHEBI:13879
alt_id: CHEBI:22717
def: "The simplest member of the class of  benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1." []
subset: 3:STAR
synonym: "Benzenecarboxylate" RELATED [hmdb]
synonym: "Benzeneformate" RELATED [hmdb]
synonym: "Benzenemethanoate" RELATED [hmdb]
synonym: "benzoate" RELATED [uniprot_ft]
synonym: "benzoate anion" RELATED [nist]
synonym: "benzoic acid, ion(1-)" RELATED [chemidplus]
synonym: "Phenylcarboxylate" RELATED [hmdb]
synonym: "Phenylformate" RELATED [hmdb]
is_a: CHEBI:22718 ! benzoates
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0018033 CHEBI:30746 ! benzoic acid

[Term]
id: CHEBI:161680
name: aztreonam
namespace: chebi_ontology
alt_id: CHEBI:2960
alt_id: CHEBI:41008
def: "A synthetic monocyclic β-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking." []
subset: 3:STAR
synonym: "(Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid" RELATED [chemidplus]
synonym: "AZT" RELATED [chebi]
is_a: CHEBI:50695 ! monobactam
is_a: CHEBI:88225 ! beta-lactam antibiotic allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50696 ! has role EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen

[Term]
id: CHEBI:16189
name: sulfate
namespace: chebi_ontology
alt_id: CHEBI:15135
alt_id: CHEBI:45687
alt_id: CHEBI:9335
def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." []
subset: 3:STAR
synonym: "[SO4](2-)" RELATED [iupac]
synonym: "SO4(2-)" RELATED [iupac]
synonym: "Sulfate" EXACT [KEGG_COMPOUND]
synonym: "Sulfate" RELATED [kegg.compound]
synonym: "sulfate" RELATED [uniprot_ft]
synonym: "Sulfate anion(2-)" RELATED [hmdb]
synonym: "Sulfate dianion" RELATED [hmdb]
synonym: "SULFATE ION" RELATED [pdb-ccd]
synonym: "Sulfate(2-)" RELATED [hmdb]
synonym: "Sulfuric acid ion(2-)" RELATED [hmdb]
synonym: "sulphate" RELATED [chebi]
synonym: "sulphate ion" RELATED [chebi]
is_a: CHEBI:33482 ! sulfur oxoanion
is_a: CHEBI:48154 ! sulfur oxide
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:45696 ! hydrogensulfate

[Term]
id: CHEBI:16199
name: urea
namespace: chebi_ontology
alt_id: CHEBI:15292
alt_id: CHEBI:27218
alt_id: CHEBI:46379
alt_id: CHEBI:9888
def: "A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O)." []
subset: 3:STAR
synonym: "1728" RELATED [ppdb]
synonym: "Carbamide" RELATED [kegg.compound]
synonym: "carbonyldiamide" RELATED [nist]
synonym: "E927b" RELATED [chebi]
synonym: "H2NC(O)NH2" RELATED [chebi]
synonym: "Harnstoff" RELATED [nist]
synonym: "Karbamid" RELATED [chebi]
synonym: "ur" RELATED [iupac]
synonym: "UREA" EXACT [PDBeChem]
synonym: "UREA" RELATED [pdb-ccd]
synonym: "Urea" EXACT [KEGG_COMPOUND]
synonym: "Urea" RELATED [kegg.compound]
synonym: "urea" RELATED [uniprot_ft]
synonym: "uree" RELATED [chebi]
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
relationship: RO:0000087 CHEBI:64577 ! has role flour treatment agent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018036 CHEBI:48376 ! carbamimidic acid
relationship: RO:0018038 CHEBI:28976 ! carbonic acid

[Term]
id: CHEBI:16215
name: phosphonate(2-)
namespace: chebi_ontology
alt_id: CHEBI:14820
alt_id: CHEBI:39856
alt_id: CHEBI:8154
def: "A divalent inorganic anion obtained by removal of both protons from phosphonic acid" []
subset: 3:STAR
synonym: "[PHO3](2-)" RELATED [iupac]
synonym: "PHO3(2-)" RELATED [iupac]
synonym: "PHOSPHONATE" RELATED [pdb-ccd]
synonym: "Phosphonate" RELATED [kegg.compound]
synonym: "phosphonate" RELATED [iupac, uniprot_ft]
is_a: CHEBI:33461 ! phosphorus oxoanion
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0018033 CHEBI:33462 ! phosphonate(1-)

[Term]
id: CHEBI:16240
name: hydrogen peroxide
namespace: chebi_ontology
alt_id: CHEBI:13354
alt_id: CHEBI:13355
alt_id: CHEBI:24637
alt_id: CHEBI:44812
alt_id: CHEBI:5586
def: "An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond." []
subset: 3:STAR
synonym: "[OH(OH)]" RELATED [molbase]
synonym: "dihydrogen dioxide" RELATED [iupac]
synonym: "H(2)O(2)" RELATED [uniprot_ft]
synonym: "H2O2" RELATED [kegg.compound]
synonym: "HOOH" RELATED [iupac]
synonym: "HYDROGEN PEROXIDE" EXACT [PDBeChem]
synonym: "HYDROGEN PEROXIDE" RELATED [pdb-ccd]
synonym: "Hydrogen peroxide" EXACT [KEGG_COMPOUND]
synonym: "Hydrogen peroxide" RELATED [kegg.compound]
synonym: "Oxydol" RELATED [kegg.compound]
synonym: "perhydrol" RELATED [metacyc.compound]
is_a: CHEBI:24837 ! inorganic peroxide
is_a: CHEBI:26523 ! reactive oxygen species
relationship: RO:0000087 CHEBI:132717 ! has role bleaching agent
relationship: RO:0000087 CHEBI:149552 ! has role emetic
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:48219 ! has role disinfectant
relationship: RO:0000087 CHEBI:50902 ! has role genotoxin
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:59163 ! has role biomarker
relationship: RO:0000087 CHEBI:63490 ! has role explosive
relationship: RO:0000087 CHEBI:65259 ! has role GABA antagonist
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:29192 ! hydrogenperoxide(1-)

[Term]
id: CHEBI:16247
name: phospholipid
namespace: chebi_ontology
alt_id: CHEBI:14816
alt_id: CHEBI:26063
alt_id: CHEBI:8150
def: "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." []
subset: 3:STAR
synonym: "a phospholipid derivative" RELATED [uniprot_ft]
synonym: "Phospholipid" RELATED [kegg.compound]
synonym: "phospholipids" RELATED [chebi]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
relationship: RO:0018034 CHEBI:62643 ! anionic phospholipid

[Term]
id: CHEBI:16313
name: D-proline
namespace: chebi_ontology
alt_id: CHEBI:13008
alt_id: CHEBI:21070
alt_id: CHEBI:42012
alt_id: CHEBI:42129
alt_id: CHEBI:42213
alt_id: CHEBI:4226
alt_id: CHEBI:45156
alt_id: CHEBI:45161
def: "The <small>D</small>-enantiomer of proline." []
subset: 3:STAR
synonym: "(2R)-pyrrolidine-2-carboxylic acid" RELATED [iupac]
synonym: "(R)-2-Carboxypyrrolidine" RELATED [hmdb]
synonym: "(R)-pyrrolidine-2-carboxylic acid" RELATED [chebi]
synonym: "D-Prolin" RELATED [chebi]
synonym: "D-PROLINE" RELATED [pdb-ccd]
synonym: "D-Proline" EXACT [KEGG_COMPOUND]
synonym: "D-Proline" RELATED [kegg.compound]
synonym: "DPR" RELATED [pdb-ccd]
is_a: CHEBI:16733 ! D-alpha-amino acid
is_a: CHEBI:26271 ! proline
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018033 CHEBI:32868 ! D-prolinium
relationship: RO:0018034 CHEBI:32867 ! D-prolinate
relationship: RO:0018036 CHEBI:57726 ! D-proline zwitterion
relationship: RO:0018039 CHEBI:17203 ! L-proline

[Term]
id: CHEBI:16385
name: organic sulfide
namespace: chebi_ontology
alt_id: CHEBI:13694
alt_id: CHEBI:26960
alt_id: CHEBI:9340
def: "Compounds having the structure RSR (R ≠ H). Such compounds were once called thioethers." []
subset: 3:STAR
synonym: "organic sulfides" RELATED [chebi]
synonym: "RSR" RELATED [iupac]
synonym: "Sulfide" RELATED [kegg.compound]
synonym: "Thioether" RELATED [kegg.compound]
synonym: "thioethers" RELATED [iupac]
is_a: CHEBI:26822 ! sulfide
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:164200
name: triclosan
namespace: chebi_ontology
alt_id: CHEBI:29697
alt_id: CHEBI:47700
def: "An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes." []
subset: 3:STAR
synonym: "2,4,4'-Trichloro-2'-hydroxydiphenyl ether" RELATED [chemidplus]
synonym: "5-Chloro-2-(2,4-dichloro-phenoxy)-phenol" RELATED [chembl]
synonym: "Triclosan" RELATED [kegg.compound]
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:83403 ! monochlorobenzenes
relationship: RO:0000087 CHEBI:139512 ! has role EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor
relationship: RO:0000087 CHEBI:24127 ! has role fungicide
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:38068 ! has role antimalarial
relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor
relationship: RO:0000087 CHEBI:77853 ! has role persistent organic pollutant
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen

[Term]
id: CHEBI:16541
name: protein polypeptide chain
namespace: chebi_ontology
alt_id: CHEBI:8526
def: "A naturally occurring polypeptide synthesized at the ribosome." []
subset: 3:STAR
subset: 3_STAR
synonym: "a protein" RELATED [UniProt]
synonym: "a protein" RELATED [uniprot_ft]
synonym: "polypeptide chain" RELATED [ChEBI]
synonym: "polypeptide chain" RELATED [chebi]
synonym: "Protein" RELATED [kegg.compound]
synonym: "Protein" RELATED [KEGG_COMPOUND]
synonym: "protein polypeptide chains" RELATED [chebi]
synonym: "protein polypeptide chains" RELATED [ChEBI]
xref: KEGG:C00017
is_a: CHEBI:15841 ! polypeptide
relationship: BFO:0000051 CHEBI:33700 ! has part proteinogenic amino-acid residue

[Term]
id: CHEBI:16646
name: carbohydrate
namespace: chebi_ontology
alt_id: CHEBI:15131
alt_id: CHEBI:23008
alt_id: CHEBI:9318
def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
subset: 3:STAR
synonym: "a carbohydrate" RELATED [uniprot_ft]
synonym: "carbohidrato" RELATED [iupac]
synonym: "carbohidratos" RELATED [iupac]
synonym: "glucide" RELATED [chebi]
synonym: "glucides" RELATED [chebi]
synonym: "glucido" RELATED [chebi]
synonym: "glucidos" RELATED [chebi]
synonym: "hydrates de carbone" RELATED [chebi]
synonym: "Kohlenhydrat" RELATED [chebi]
synonym: "Kohlenhydrate" RELATED [chebi]
synonym: "saccharide" RELATED [iupac]
synonym: "saccharides" RELATED [iupac]
synonym: "saccharidum" RELATED [chebi]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16670
name: peptide
namespace: chebi_ontology
alt_id: CHEBI:14753
alt_id: CHEBI:25906
alt_id: CHEBI:7990
def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." []
subset: 3:STAR
subset: 3_STAR
synonym: "Peptid" RELATED [chebi]
synonym: "Peptid" RELATED [ChEBI]
synonym: "Peptide" EXACT [KEGG_COMPOUND]
synonym: "Peptide" RELATED [kegg.compound]
synonym: "peptido" RELATED [chebi]
synonym: "peptido" RELATED [ChEBI]
synonym: "peptidos" RELATED [chebi]
synonym: "peptidos" RELATED [ChEBI]
xref: KEGG:C00012
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:50047 ! organic amino compound
relationship: BFO:0000051 CHEBI:33708 ! has part amino-acid residue
relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion
relationship: RO:0018036 CHEBI:60466 ! peptide zwitterion

[Term]
id: CHEBI:16704
name: uridine
namespace: chebi_ontology
alt_id: CHEBI:15296
alt_id: CHEBI:27227
alt_id: CHEBI:46386
alt_id: CHEBI:46391
alt_id: CHEBI:46460
alt_id: CHEBI:46463
alt_id: CHEBI:9893
def: "A ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a β‒N<small><sup>1</small></sup>-glycosidic bond." []
subset: 3:STAR
synonym: "1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione" RELATED [chebi]
synonym: "1-beta-D-ribofuranosyluracil" RELATED [hmdb]
synonym: "beta-Uridine" RELATED [hmdb]
synonym: "u" RELATED [chebi]
synonym: "Urd" RELATED [iubmb]
synonym: "Uridin" RELATED [chemidplus]
synonym: "URIDINE" EXACT [PDBeChem]
synonym: "URIDINE" RELATED [pdb-ccd]
synonym: "Uridine" EXACT [KEGG_COMPOUND]
synonym: "Uridine" RELATED [kegg.compound]
synonym: "uridine" RELATED [uniprot_ft]
is_a: CHEBI:27242 ! uridines
relationship: RO:0000087 CHEBI:49103 ! has role drug metabolite
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite

[Term]
id: CHEBI:16705
name: 6-aminopenicillanic acid
namespace: chebi_ontology
alt_id: CHEBI:20705
alt_id: CHEBI:2172
def: "A penicillanic acid compound having a (6<i>R</i>)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics." []
subset: 3:STAR
synonym: "(+)-6-aminopenicillanic acid" RELATED [chebi]
synonym: "(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "6-Aminopenicillamine acid" RELATED [chemidplus]
synonym: "6-Aminopenicillanate" RELATED [kegg.compound]
synonym: "6-Aminopenicillanic acid" RELATED [kegg.compound]
synonym: "6-APA" RELATED [chebi]
synonym: "6-Apa" RELATED [chemidplus]
synonym: "6-Aps" RELATED [chemidplus]
synonym: "6beta-aminopenicillanic acid" RELATED [chebi]
synonym: "Aminopenicillanic acid" RELATED [chemidplus]
synonym: "Penicin" RELATED [chemidplus]
synonym: "Penin" RELATED [chemidplus]
synonym: "Phenacyl 6-aminopenicillinate" RELATED [chemidplus]
is_a: CHEBI:25865 ! penicillanic acids
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0018034 CHEBI:30938 ! 6-aminopenicillanate
relationship: RO:0018036 CHEBI:57869 ! 6-aminopenicillanic acid zwitterion
relationship: RO:0018038 CHEBI:37806 ! penicillanic acid

[Term]
id: CHEBI:16716
name: benzene
namespace: chebi_ontology
alt_id: CHEBI:13876
alt_id: CHEBI:22703
alt_id: CHEBI:3025
alt_id: CHEBI:41187
def: "A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised π system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system." []
subset: 3:STAR
synonym: "[6]annulene" RELATED [nist]
synonym: "Benzen" RELATED [iupac]
synonym: "BENZENE" EXACT [PDBeChem]
synonym: "BENZENE" RELATED [pdb-ccd]
synonym: "Benzene" EXACT [KEGG_COMPOUND]
synonym: "Benzene" RELATED [kegg.compound]
synonym: "benzene" RELATED [chebi, uniprot_ft]
synonym: "Benzine" RELATED [umbbd.compound]
synonym: "Benzol" RELATED [chemidplus]
synonym: "benzole" RELATED [nist]
synonym: "Bicarburet of hydrogen" RELATED [chemidplus]
synonym: "Coal naphtha" RELATED [chemidplus]
synonym: "cyclohexatriene" RELATED [umbbd.compound]
synonym: "Mineral naphtha" RELATED [chemidplus]
synonym: "Phene" RELATED [chemidplus]
synonym: "phenyl hydride" RELATED [umbbd.compound]
synonym: "Pyrobenzol" RELATED [chemidplus]
synonym: "Pyrobenzole" RELATED [chemidplus]
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33842 ! aromatic annulene
relationship: RO:0000087 CHEBI:48355 ! has role non-polar solvent
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant

[Term]
id: CHEBI:167164
name: mineral nutrient
namespace: chebi_ontology
def: "A mineral that is an inorganic nutrient which must be ingested and absorbed in adequate amounts to satisfy a wide range of essential metabolic and/or structural functions in the human body." []
subset: 3:STAR
synonym: "mineral nutrient" RELATED [chebi]
synonym: "mineral nutrients" RELATED [chebi]
synonym: "nutrient mineral" RELATED [chebi]
synonym: "nutrient minerals" RELATED [chebi]
is_a: CHEBI:46662 ! mineral
relationship: RO:0000087 CHEBI:33284 ! has role nutrient

[Term]
id: CHEBI:167183
name: piscicide
namespace: chebi_ontology
def: "A substance which is poisonous to fish and is primarily used to eliminate dominant species of fish in water." []
subset: 3:STAR
synonym: "piscicides" RELATED [chebi]
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:16733
name: D-alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:12909
alt_id: CHEBI:13625
alt_id: CHEBI:20906
alt_id: CHEBI:4097
subset: 3:STAR
synonym: "D-alpha-amino acid" RELATED [chebi]
synonym: "D-alpha-amino acids" RELATED [chebi]
synonym: "D-Amino acid" RELATED [kegg.compound]
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
relationship: RO:0018034 CHEBI:60895 ! D-alpha-amino acid anion
relationship: RO:0018036 CHEBI:59871 ! D-alpha-amino acid zwitterion

[Term]
id: CHEBI:167559
name: glycan
namespace: chebi_ontology
def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also <a href=\"http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001\" target=\"_blank\">http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001</a>." []
subset: 3:STAR
synonym: "glycans" RELATED [chebi]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16914
name: salicylic acid
namespace: chebi_ontology
alt_id: CHEBI:26597
alt_id: CHEBI:45521
alt_id: CHEBI:9006
def: "A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the <em>ortho</em> position. It is obtained from the bark of the white willow and wintergreen leaves." []
subset: 3:STAR
synonym: "2-carboxyphenol" RELATED [nist]
synonym: "2-HYDROXYBENZOIC ACID" EXACT [PDBeChem]
synonym: "2-HYDROXYBENZOIC ACID" RELATED [pdb-ccd]
synonym: "o-carboxyphenol" RELATED [nist]
synonym: "o-Hydroxybenzoic acid" RELATED [kegg.compound]
synonym: "o-hydroxybenzoic acid" RELATED [nist]
synonym: "Salicylic acid" RELATED [kegg.compound]
is_a: CHEBI:25389 ! monohydroxybenzoic acid
relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:37848 ! has role plant hormone
relationship: RO:0000087 CHEBI:50176 ! has role keratolytic drug
relationship: RO:0000087 CHEBI:73181 ! has role EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018034 CHEBI:30762 ! salicylate

[Term]
id: CHEBI:16976
name: hygromycin B
namespace: chebi_ontology
alt_id: CHEBI:14426
alt_id: CHEBI:24752
alt_id: CHEBI:43202
alt_id: CHEBI:5821
subset: 3:STAR
synonym: "Antibiotic A-396-II" RELATED [kegg.compound]
synonym: "HYGROMYCIN B" RELATED [pdb-ccd]
synonym: "Hygromycin B" RELATED [kegg.compound]
synonym: "O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N(3)-methyl-D-streptamine" RELATED [chebi]
is_a: CHEBI:24753 ! hygromycin
is_a: CHEBI:71989 ! ortho ester
relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug
relationship: RO:0018033 CHEBI:57971 ! hygromycin B(3+)

[Term]
id: CHEBI:17029
name: chitin
namespace: chebi_ontology
alt_id: CHEBI:13962
alt_id: CHEBI:23099
alt_id: CHEBI:3596
def: "An aminoglycan consisting of β-(1→4)-linked <em>N</em>-acetyl-<small>D</small>-glucosamine residues." []
subset: 3:STAR
synonym: "[1,4-(N-Acetyl-beta-D-glucosaminyl)]n" RELATED [kegg.compound]
synonym: "[4)-beta-D-GlcpNAc(1->]n" RELATED [iupac]
synonym: "beta-1,4-Poly-N-acetyl-D-glucosamine" RELATED [kegg.compound]
synonym: "Chitin" RELATED [kegg.compound]
synonym: "chitin" RELATED [iupac, uniprot_ft]
is_a: CHEBI:21638 ! N-acylglucosamine
is_a: CHEBI:22506 ! aminoglycan
relationship: RO:0000087 CHEBI:73336 ! has role vulnerary
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:17076
name: streptomycin
namespace: chebi_ontology
alt_id: CHEBI:15119
alt_id: CHEBI:26784
alt_id: CHEBI:45745
alt_id: CHEBI:9284
def: "A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. The parent of the streptomycin class" []
subset: 3:STAR
synonym: "2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside" RELATED [chemidplus]
synonym: "[2-deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl]-(1->2)-[5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl]-(1->4)-{N',N'''-[(1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidine}" RELATED [iupac]
synonym: "SM" RELATED [kegg.drug]
synonym: "streomycin" RELATED [chebi]
synonym: "STREPTOMYCIN" RELATED [pdb-ccd]
is_a: CHEBI:26788 ! streptomycins
is_a: CHEBI:87113 ! antibiotic antifungal drug
is_a: CHEBI:87114 ! antibiotic fungicide
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018033 CHEBI:58007 ! streptomycin(3+)
relationship: RO:0018038 CHEBI:27405 ! streptidine

[Term]
id: CHEBI:17087
name: ketone
namespace: chebi_ontology
alt_id: CHEBI:13427
alt_id: CHEBI:13646
alt_id: CHEBI:24974
alt_id: CHEBI:6127
alt_id: CHEBI:8742
def: "A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H)." []
subset: 3:STAR
synonym: "a ketone" RELATED [uniprot_ft]
synonym: "cetone" RELATED [chebi]
synonym: "Keton" RELATED [chebi]
synonym: "Ketone" RELATED [kegg.compound]
synonym: "ketones" EXACT [ChEBI]
synonym: "ketones" RELATED [chebi]
synonym: "R-CO-R'" RELATED [kegg.compound]
is_a: CHEBI:36586 ! carbonyl compound

[Term]
id: CHEBI:17137
name: hydrogensulfite
namespace: chebi_ontology
alt_id: CHEBI:13367
alt_id: CHEBI:5598
subset: 3:STAR
synonym: "[SO2(OH)](-)" RELATED [iupac]
synonym: "Bisulfite" RELATED [kegg.compound]
synonym: "bisulfite" RELATED [chemidplus]
synonym: "bisulphite" RELATED [chemidplus]
synonym: "HSO3(-)" RELATED [iupac]
synonym: "HSO3-" RELATED [kegg.compound]
synonym: "Hydrogen sulfite" RELATED [kegg.compound]
synonym: "hydrogen sulfite(1-)" RELATED [chemidplus]
synonym: "hydrosulfite anion" RELATED [chemidplus]
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:48854 ! sulfurous acid
relationship: RO:0018034 CHEBI:17359 ! sulfite

[Term]
id: CHEBI:17154
name: nicotinamide
namespace: chebi_ontology
alt_id: CHEBI:14645
alt_id: CHEBI:25521
alt_id: CHEBI:44258
alt_id: CHEBI:7556
def: "A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group." []
subset: 3:STAR
synonym: "3-carbamoylpyridine" RELATED [chemidplus]
synonym: "3-pyridinecarboxamide" RELATED [nist]
synonym: "beta-pyridinecarboxamide" RELATED [chemidplus, nist]
synonym: "m-(aminocarbonyl)pyridine" RELATED [chemidplus]
synonym: "niacin" RELATED [chebi]
synonym: "Niacinamide" RELATED [kegg.compound]
synonym: "niamide" RELATED [chemidplus]
synonym: "Nicotinamid" RELATED [chebi]
synonym: "nicotinamide" RELATED [uniprot_ft]
synonym: "nicotine acid amide" RELATED [chemidplus]
synonym: "nicotine amide" RELATED [chemidplus]
synonym: "nicotinic acid amide" RELATED [chemidplus]
synonym: "nicotinic amide" RELATED [chemidplus]
synonym: "Nicotinsaeureamid" RELATED [chebi]
synonym: "nicotylamide" RELATED [chemidplus]
synonym: "Nikotinamid" RELATED [chemidplus]
synonym: "Nikotinsaeureamid" RELATED [chebi]
synonym: "pyridine-3-carboxylic acid amide" RELATED [chemidplus]
synonym: "vitamin B3" RELATED [chemidplus]
synonym: "Vitamin PP" RELATED [kegg.compound]
is_a: CHEBI:176839 ! vitamin B3
is_a: CHEBI:25529 ! pyridinecarboxamide
is_a: CHEBI:26416 ! pyridine alkaloid
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:62913 ! has role EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent
relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent
relationship: RO:0000087 CHEBI:71181 ! has role Sir2 inhibitor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:84087 ! has role human urinary metabolite
relationship: RO:0018038 CHEBI:15940 ! nicotinic acid

[Term]
id: CHEBI:171664
name: antiamoebic agent
namespace: chebi_ontology
def: "An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae." []
subset: 3:STAR
synonym: "amebicide" RELATED [chebi]
synonym: "amebicides" RELATED [chebi]
synonym: "amoebicide" RELATED [chebi]
synonym: "amoebicides" RELATED [chebi]
synonym: "anti-amoebic agent" RELATED [chebi]
synonym: "anti-amoebic agents" RELATED [chebi]
synonym: "anti-amoebic drug" RELATED [chebi]
synonym: "anti-amoebic drugs" RELATED [chebi]
synonym: "antiamoebic" RELATED [chebi]
synonym: "antiamoebic agents" RELATED [chebi]
synonym: "antiamoebic drug" RELATED [chebi]
synonym: "antiamoebic drugs" RELATED [chebi]
synonym: "antiamoebics" RELATED [chebi]
is_a: CHEBI:35442 ! antiparasitic agent

[Term]
id: CHEBI:17203
name: L-proline
namespace: chebi_ontology
alt_id: CHEBI:13154
alt_id: CHEBI:184637
alt_id: CHEBI:21373
alt_id: CHEBI:42067
alt_id: CHEBI:45040
alt_id: CHEBI:45100
alt_id: CHEBI:45159
alt_id: CHEBI:6286
def: "Pyrrolidine in which the <em>pro</em>-<i>S</i> hydrogen at position 2 is substituted by a carboxylic acid group. <small>L</small>-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group α to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles." []
subset: 3:STAR
synonym: "(-)-(S)-proline" RELATED [nist]
synonym: "(-)-2-pyrrolidinecarboxylic acid" RELATED [chemidplus]
synonym: "(-)-proline" RELATED [chemidplus]
synonym: "(2S)-pyrrolidine-2-carboxylic acid" RELATED [iupac]
synonym: "(S)-2-carboxypyrrolidine" RELATED [drugbank]
synonym: "(S)-2-pyrrolidinecarboxylic acid" RELATED [chemidplus]
synonym: "(S)-pyrrolidine-2-carboxylic acid" RELATED [chebi]
synonym: "2-Pyrrolidinecarboxylic acid" RELATED [kegg.compound]
synonym: "L-(-)-proline" RELATED [nist]
synonym: "L-alpha-pyrrolidinecarboxylic acid" RELATED [chemidplus]
synonym: "L-Prolin" RELATED [chebi]
synonym: "L-Proline" EXACT [KEGG_COMPOUND]
synonym: "L-Proline" RELATED [kegg.compound]
synonym: "L-pyrrolidine-2-carboxylic acid" RELATED [chemidplus]
synonym: "P" RELATED [chebi]
synonym: "prolina" RELATED [chemidplus]
synonym: "PROLINE" EXACT [PDBeChem]
synonym: "PROLINE" RELATED [pdb-ccd]
synonym: "prolinum" RELATED [chemidplus]
is_a: CHEBI:24318 ! glutamine family amino acid
is_a: CHEBI:26271 ! proline
relationship: RO:0000087 CHEBI:23366 ! has role compatible osmolytes
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018033 CHEBI:32864 ! L-prolinium
relationship: RO:0018034 CHEBI:32862 ! L-prolinate
relationship: RO:0018036 CHEBI:60039 ! L-proline zwitterion
relationship: RO:0018039 CHEBI:16313 ! D-proline

[Term]
id: CHEBI:17234
name: glucose
namespace: chebi_ontology
alt_id: CHEBI:14313
alt_id: CHEBI:24277
alt_id: CHEBI:33929
alt_id: CHEBI:5418
def: "An aldohexose used as a source of energy and metabolic intermediate." []
subset: 3:STAR
synonym: "DL-glucose" RELATED [chebi]
synonym: "Glc" RELATED [jcbn]
synonym: "Glucose" EXACT [KEGG_COMPOUND]
synonym: "Glucose" RELATED [kegg.compound]
synonym: "Glukose" RELATED [chebi]
is_a: CHEBI:33917 ! aldohexose
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite

[Term]
id: CHEBI:17296
name: aniline
namespace: chebi_ontology
alt_id: CHEBI:13834
alt_id: CHEBI:22561
alt_id: CHEBI:2732
alt_id: CHEBI:40796
def: "A primary arylamine in which an amino functional group is substituted for one of the benzene hydrogens." []
subset: 3:STAR
synonym: "aminobenzene" RELATED [chemidplus]
synonym: "aminophen" RELATED [chemidplus]
synonym: "Anilin" RELATED [nist]
synonym: "ANILINE" EXACT [PDBeChem]
synonym: "ANILINE" RELATED [pdb-ccd]
synonym: "Aniline" EXACT [KEGG_COMPOUND]
synonym: "Aniline" RELATED [kegg.compound]
synonym: "aniline" RELATED [uniprot_ft]
synonym: "Benzenamine" RELATED [kegg.compound]
synonym: "benzeneamine" RELATED [nist]
synonym: "kyanol" RELATED [nist]
synonym: "Phenylamine" RELATED [kegg.compound]
is_a: CHEBI:22562 ! anilines
is_a: CHEBI:50471 ! primary arylamine

[Term]
id: CHEBI:173084
name: ferroptosis inhibitor
namespace: chebi_ontology
def: "Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms." []
subset: 3:STAR
synonym: "ferroptosis inhibitors" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:17334
name: penicillin
namespace: chebi_ontology
alt_id: CHEBI:14742
alt_id: CHEBI:25869
alt_id: CHEBI:7961
def: "Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6." []
subset: 3:STAR
synonym: "Penicillin" RELATED [kegg.compound]
synonym: "penicillins" RELATED [chebi]
is_a: CHEBI:25865 ! penicillanic acids
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0018034 CHEBI:51356 ! penicillinate anion
relationship: RO:0018038 CHEBI:16705 ! 6-aminopenicillanic acid

[Term]
id: CHEBI:17359
name: sulfite
namespace: chebi_ontology
alt_id: CHEBI:15139
alt_id: CHEBI:45548
def: "A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H<small><sub>2</sub></small>SO<small><sub>3</sub></small>)." []
subset: 3:STAR
synonym: "[SO3](2-)" RELATED [iupac]
synonym: "SO3" RELATED [chebi]
synonym: "SO3(2-)" RELATED [iupac]
synonym: "sulfite" RELATED [uniprot_ft]
synonym: "SULFITE ION" RELATED [pdb-ccd]
synonym: "sulphite" RELATED [chebi]
is_a: CHEBI:33482 ! sulfur oxoanion
is_a: CHEBI:48154 ! sulfur oxide
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0018033 CHEBI:17137 ! hydrogensulfite

[Term]
id: CHEBI:17418
name: valeric acid
namespace: chebi_ontology
alt_id: CHEBI:113448
alt_id: CHEBI:27263
alt_id: CHEBI:27264
alt_id: CHEBI:43606
alt_id: CHEBI:44803
alt_id: CHEBI:7980
def: "A straight-chain saturated fatty acid containing five carbon atoms." []
subset: 3:STAR
synonym: "1-butanecarboxylic acid" RELATED [chemidplus, nist]
synonym: "CH3-[CH2]3-COOH" RELATED [iupac]
synonym: "n-BuCOOH" RELATED [chebi]
synonym: "n-Pentanoate" RELATED [kegg.compound]
synonym: "n-pentanoic acid" RELATED [chemidplus]
synonym: "n-Valeric acid" RELATED [kegg.compound]
synonym: "n-valeric acid" RELATED [chemidplus]
synonym: "Pentanoate" EXACT [KEGG_COMPOUND]
synonym: "Pentanoate" RELATED [kegg.compound]
synonym: "PENTANOIC ACID" EXACT [PDBeChem]
synonym: "PENTANOIC ACID" RELATED [pdb-ccd]
synonym: "Pentanoic acid" EXACT [KEGG_COMPOUND]
synonym: "Pentanoic acid" RELATED [kegg.compound]
synonym: "pentoic acid" RELATED [chebi]
synonym: "propylacetic acid" RELATED [chemidplus]
synonym: "Valerate" RELATED [kegg.compound]
synonym: "Valerianic acid" RELATED [kegg.compound]
synonym: "Valeriansaeure" RELATED [chebi]
synonym: "Valeric acid" RELATED [kegg.compound]
synonym: "valeric acid, normal" RELATED [chemidplus]
is_a: CHEBI:26666 ! short-chain fatty acid
is_a: CHEBI:39418 ! straight-chain saturated fatty acid
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0018034 CHEBI:31011 ! valerate

[Term]
id: CHEBI:17478
name: aldehyde
namespace: chebi_ontology
alt_id: CHEBI:13432
alt_id: CHEBI:13753
alt_id: CHEBI:13805
alt_id: CHEBI:13806
alt_id: CHEBI:17496
alt_id: CHEBI:22291
alt_id: CHEBI:2554
alt_id: CHEBI:8750
def: "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." []
subset: 3:STAR
synonym: "aldehido" RELATED [chebi]
synonym: "aldehidos" RELATED [chebi]
synonym: "Aldehyd" RELATED [chebi]
synonym: "Aldehyde" EXACT [KEGG_COMPOUND]
synonym: "Aldehyde" RELATED [kegg.compound]
synonym: "aldehyde" RELATED [chebi]
synonym: "aldehydes" RELATED [chebi]
synonym: "aldehydum" RELATED [chebi]
synonym: "an aldehyde" RELATED [uniprot_ft]
synonym: "RC(=O)H" RELATED [iupac]
synonym: "RCHO" RELATED [kegg.compound]
is_a: CHEBI:36586 ! carbonyl compound
relationship: BFO:0000051 CHEBI:42485 ! has part formyl group

[Term]
id: CHEBI:17489
name: 3',5'-cyclic AMP
namespace: chebi_ontology
alt_id: CHEBI:11673
alt_id: CHEBI:1325
alt_id: CHEBI:19827
alt_id: CHEBI:41588
def: "A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase." []
subset: 3:STAR
synonym: "3',5'-Cyclic AMP" RELATED [kegg.compound]
synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [nist]
synonym: "Adenosine 3',5'-cyclic phosphate" RELATED [kegg.compound]
synonym: "Adenosine 3',5'-phosphate" EXACT [KEGG_COMPOUND]
synonym: "Adenosine 3',5'-phosphate" RELATED [kegg.compound]
synonym: "ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE" RELATED [pdb-ccd]
synonym: "cAMP" RELATED [kegg.compound]
synonym: "Cyclic adenylic acid" RELATED [kegg.compound]
synonym: "Cyclic AMP" RELATED [kegg.compound]
is_a: CHEBI:19834 ! 3',5'-cyclic purine nucleotide
is_a: CHEBI:61296 ! adenyl ribonucleotide
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:58165 ! 3',5'-cyclic AMP(1-)

[Term]
id: CHEBI:17499
name: hydrogen donor
namespace: chebi_ontology
alt_id: CHEBI:13233
alt_id: CHEBI:15018
alt_id: CHEBI:8785
def: "A molecular entity that can undergo oxidation by the loss of hydrogen atom(s)." []
subset: 3:STAR
synonym: "AH(2)" RELATED [uniprot_ft]
synonym: "AH2" RELATED [kegg.compound]
synonym: "Donor" RELATED [kegg.compound]
synonym: "Hydrogen-donor" RELATED [kegg.compound]
synonym: "Reduced acceptor" RELATED [kegg.compound]
is_a: CHEBI:23367 ! molecular entity
relationship: RO:0000087 CHEBI:15022 ! has role electron donor

[Term]
id: CHEBI:17514
name: cyanide
namespace: chebi_ontology
alt_id: CHEBI:14038
alt_id: CHEBI:3969
alt_id: CHEBI:41780
def: "A pseudohalide anion that is the conjugate base of hydrogen cyanide." []
subset: 3:STAR
synonym: "CN(-)" RELATED [iupac]
synonym: "CN-" RELATED [kegg.compound]
synonym: "Cyanide" EXACT [KEGG_COMPOUND]
synonym: "Cyanide" RELATED [chebi, kegg.compound]
synonym: "CYANIDE ION" RELATED [pdb-ccd]
synonym: "Prussiate" RELATED [kegg.compound]
synonym: "Zyanid" RELATED [chebi]
is_a: CHEBI:36828 ! pseudohalide anion
relationship: RO:0000087 CHEBI:38500 ! has role EC 1.9.3.1 (cytochrome c oxidase) inhibitor
relationship: RO:0018033 CHEBI:18407 ! hydrogen cyanide
relationship: RO:0018033 CHEBI:36856 ! hydrogen isocyanide

[Term]
id: CHEBI:17522
name: alditol
namespace: chebi_ontology
alt_id: CHEBI:13754
alt_id: CHEBI:22298
alt_id: CHEBI:2556
def: "A carbohydrate that is an acyclic polyol having the general formula HOCH<small><sub>2</sub></small>[CH(OH)]<small><sub><em>n</em></sub></small>CH<small><sub>2</sub></small>OH (formally derivable from an aldose by reduction of the carbonyl group)." []
subset: 3:STAR
synonym: "Alditol" RELATED [kegg.compound]
synonym: "alditol" RELATED [uniprot_ft]
synonym: "alditols" RELATED [chebi]
synonym: "Glycitol" RELATED [kegg.compound]
synonym: "Sugar alcohol" RELATED [kegg.compound]
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:26191 ! polyol

[Term]
id: CHEBI:17544
name: hydrogencarbonate
namespace: chebi_ontology
alt_id: CHEBI:13363
alt_id: CHEBI:22863
alt_id: CHEBI:40961
alt_id: CHEBI:5589
def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." []
subset: 3:STAR
synonym: "[CO2(OH)](-)" RELATED [iupac]
synonym: "Acid carbonate" RELATED [kegg.compound]
synonym: "Bicarbonate" RELATED [kegg.compound]
synonym: "BICARBONATE ION" RELATED [pdb-ccd]
synonym: "HCO3(-)" RELATED [iupac]
synonym: "HCO3-" RELATED [kegg.compound]
synonym: "hydrogen carbonate" RELATED [pdb-ccd]
synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND]
synonym: "Hydrogencarbonate" RELATED [kegg.compound]
synonym: "hydrogencarbonate" RELATED [uniprot_ft]
is_a: CHEBI:35604 ! carbon oxoanion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:28976 ! carbonic acid
relationship: RO:0018034 CHEBI:41609 ! carbonate

[Term]
id: CHEBI:17568
name: uracil
namespace: chebi_ontology
alt_id: CHEBI:15288
alt_id: CHEBI:27210
alt_id: CHEBI:46375
alt_id: CHEBI:9882
def: "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." []
subset: 3:STAR
synonym: "2,4(1H,3H)-pyrimidinedione" RELATED [nist]
synonym: "2,4-Dioxopyrimidine" RELATED [hmdb]
synonym: "2,4-Pyrimidinedione" RELATED [hmdb]
synonym: "U" RELATED [chebi]
synonym: "Ura" RELATED [iubmb]
synonym: "URACIL" RELATED [pdb-ccd]
synonym: "Uracil" RELATED [kegg.compound]
synonym: "uracil" RELATED [uniprot_ft]
synonym: "Urazil" RELATED [chebi]
is_a: CHEBI:26432 ! pyrimidine nucleobase
is_a: CHEBI:38337 ! pyrimidone
relationship: RO:0000087 CHEBI:50266 ! has role prodrug
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018036 CHEBI:43254 ! (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one

[Term]
id: CHEBI:17608
name: D-aldohexose
namespace: chebi_ontology
alt_id: CHEBI:12990
alt_id: CHEBI:21038
def: "Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule." []
subset: 3:STAR
synonym: "D-aldohexoses" RELATED [chebi]
is_a: CHEBI:33917 ! aldohexose
is_a: CHEBI:4194 ! D-hexose

[Term]
id: CHEBI:17630
name: kanamycin A
namespace: chebi_ontology
alt_id: CHEBI:14487
alt_id: CHEBI:24945
alt_id: CHEBI:24947
alt_id: CHEBI:28008
alt_id: CHEBI:43482
alt_id: CHEBI:6106
subset: 3:STAR
synonym: "4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside" RELATED [chemidplus]
synonym: "4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside" RELATED [chemidplus]
synonym: "KANAMYCIN A" RELATED [pdb-ccd]
synonym: "Kanamycin A" RELATED [kegg.compound]
synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine" RELATED [chemidplus]
is_a: CHEBI:24951 ! kanamycins
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018033 CHEBI:58214 ! kanamycin A(4+)

[Term]
id: CHEBI:17634
name: D-glucose
namespace: chebi_ontology
alt_id: CHEBI:12965
alt_id: CHEBI:20999
def: "A glucose with <small>D</small>-configuration." []
subset: 3:STAR
synonym: "D(+)-glucose" RELATED [chemidplus]
synonym: "D-(+)-glucose" RELATED [nist]
synonym: "dextrose" RELATED [nist]
synonym: "grape sugar" RELATED [chemidplus]
synonym: "Traubenzucker" RELATED [chemidplus]
is_a: CHEBI:17234 ! glucose
is_a: CHEBI:17608 ! D-aldohexose

[Term]
id: CHEBI:176497
name: geroprotector
namespace: chebi_ontology
def: "Any compound that supports healthy aging, slows the biological aging process, or extends lifespan." []
subset: 3:STAR
synonym: "anti-aging agent" RELATED [chebi]
synonym: "anti-aging agents" RELATED [chebi]
synonym: "anti-aging drug" RELATED [chebi]
synonym: "anti-aging drugs" RELATED [chebi]
synonym: "geroprotective agent" RELATED [chebi]
synonym: "geroprotective agents" RELATED [chebi]
synonym: "geroprotectors" RELATED [chebi]
is_a: CHEBI:50267 ! protective agent

[Term]
id: CHEBI:17658
name: tylosin
namespace: chebi_ontology
alt_id: CHEBI:15275
alt_id: CHEBI:27172
alt_id: CHEBI:46150
alt_id: CHEBI:9787
def: "A macrolide antibiotic that is tylonolide having mono- and diglycosyl moieties attached to two of its hydroxy groups. It is found naturally as a fermentation product of <em>Streptomyces fradiae</em>." []
subset: 3:STAR
synonym: "Tylan" RELATED [chemidplus]
synonym: "Tylocine" RELATED [chemidplus]
synonym: "Tylosin" RELATED [kegg.compound]
synonym: "Tylosin A" RELATED [chemidplus]
is_a: CHEBI:17478 ! aldehyde
is_a: CHEBI:25022 ! leucomycin
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:51689 ! enone
is_a: CHEBI:63353 ! disaccharide derivative
is_a: CHEBI:63367 ! monosaccharide derivative
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0018033 CHEBI:77047 ! tylosin(1+)
relationship: RO:0018038 CHEBI:29700 ! tylactone

[Term]
id: CHEBI:176839
name: vitamin B3
namespace: chebi_ontology
def: "Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B<small><sub>3</sub></small> deficiency. Vitamin B<small><sub>3</sub></small> deficiency causes a condition known as <a href=\"https://en.wikipedia.org/wiki/Pellagra\" target=\"_blank\">pellagra</a> whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms)." []
subset: 3:STAR
synonym: "vitamin B-3" RELATED [chebi]
synonym: "vitamin B3" RELATED [chebi]
synonym: "vitamin B3 vitamer" RELATED [chebi]
synonym: "vitamin B3 vitamers" RELATED [chebi]
synonym: "vitamins B3" RELATED [chebi]
is_a: CHEBI:75769 ! B vitamin

[Term]
id: CHEBI:17698
name: chloramphenicol
namespace: chebi_ontology
alt_id: CHEBI:13965
alt_id: CHEBI:23106
alt_id: CHEBI:23108
alt_id: CHEBI:3603
alt_id: CHEBI:47327
def: "An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions." []
subset: 3:STAR
synonym: "(-)-chloramphenicol" RELATED [chebi]
synonym: "CHLORAMPHENICOL" RELATED [pdb-ccd]
synonym: "Chloramphenicol" RELATED [kegg.compound]
synonym: "chloramphenicol" RELATED [uniprot_ft]
synonym: "chlornitromycin" RELATED [chebi]
synonym: "D-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide" RELATED [chemidplus]
synonym: "D-(-)-threo-1-p-nitrophenyl-2-dichloroacetylamino-1,3-propanediol" RELATED [chemidplus]
synonym: "laevomycetinum" RELATED [chemidplus]
synonym: "levomicetina" RELATED [chemidplus]
synonym: "levomycetin" RELATED [chemidplus]
is_a: CHEBI:23824 ! diol
is_a: CHEBI:35716 ! C-nitro compound
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:37622 ! carboxamide
relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite

[Term]
id: CHEBI:17790
name: methanol
namespace: chebi_ontology
alt_id: CHEBI:14588
alt_id: CHEBI:25227
alt_id: CHEBI:44080
alt_id: CHEBI:44553
alt_id: CHEBI:6816
def: "The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group." []
subset: 3:STAR
synonym: "carbinol" RELATED [chemidplus]
synonym: "CH3OH" RELATED [chebi]
synonym: "MeOH" RELATED [chebi]
synonym: "METHANOL" EXACT [PDBeChem]
synonym: "METHANOL" RELATED [pdb-ccd]
synonym: "Methanol" EXACT [KEGG_COMPOUND]
synonym: "Methanol" RELATED [kegg.compound]
synonym: "methanol" RELATED [uniprot_ft]
synonym: "Methyl alcohol" RELATED [kegg.compound]
synonym: "Methylalkohol" RELATED [nist]
synonym: "spirit of wood" RELATED [hmdb]
synonym: "wood alcohol" RELATED [chemidplus]
synonym: "wood naphtha" RELATED [chemidplus]
synonym: "wood spirit" RELATED [nist]
is_a: CHEBI:134179 ! volatile organic compound
is_a: CHEBI:15734 ! primary alcohol
is_a: CHEBI:50584 ! alkyl alcohol
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite
relationship: RO:0000087 CHEBI:33292 ! has role fuel
relationship: RO:0000087 CHEBI:48360 ! has role amphiprotic solvent
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:52090 ! methoxide

[Term]
id: CHEBI:17792
name: organohalogen compound
namespace: chebi_ontology
alt_id: CHEBI:13444
alt_id: CHEBI:36684
alt_id: CHEBI:8767
def: "A compound containing at least one carbon-halogen bond (where X is a halogen atom)." []
subset: 3:STAR
synonym: "organic halide" RELATED [kegg.compound]
synonym: "organic halides" RELATED [chebi]
synonym: "organohalogen compounds" RELATED [chebi]
synonym: "RX" RELATED [kegg.compound, uniprot_ft]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:37578 ! halide

[Term]
id: CHEBI:17822
name: serine
namespace: chebi_ontology
alt_id: CHEBI:15081
alt_id: CHEBI:26648
alt_id: CHEBI:9116
def: "An α-amino acid that is alanine substituted at position 3 by a hydroxy group." []
subset: 3:STAR
synonym: "2-amino-3-hydroxypropanoic acid" RELATED [iupac]
synonym: "2-Amino-3-hydroxypropionic acid" RELATED [kegg.compound]
synonym: "3-Hydroxyalanine" RELATED [kegg.compound]
synonym: "Serin" RELATED [chebi]
synonym: "Serine" EXACT [KEGG_COMPOUND]
synonym: "Serine" RELATED [kegg.compound]
is_a: CHEBI:26167 ! polar amino acid
is_a: CHEBI:33704 ! alpha-amino acid
relationship: BFO:0000051 CHEBI:24712 ! has part hydroxymethyl group
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:32846 ! serinium
relationship: RO:0018034 CHEBI:32845 ! serinate
relationship: RO:0018036 CHEBI:35243 ! serine zwitterion

[Term]
id: CHEBI:17833
name: gentamycin
namespace: chebi_ontology
alt_id: CHEBI:14293
alt_id: CHEBI:24206
alt_id: CHEBI:24212
alt_id: CHEBI:5306
def: "Any of a group of aminoglycoside antibiotics produced by fermentation of some <em>Micromonospora</em> spp." []
subset: 3:STAR
synonym: "Gentamicin" RELATED [kegg.compound]
synonym: "gentamycins" RELATED [chebi]
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic

[Term]
id: CHEBI:17883
name: hydrogen chloride
namespace: chebi_ontology
alt_id: CHEBI:13364
alt_id: CHEBI:24635
alt_id: CHEBI:5590
def: "A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms." []
subset: 3:STAR
synonym: "[HCl]" RELATED [iupac]
synonym: "chlorure d'hydrogene" RELATED [chebi]
synonym: "Chlorwasserstoff" RELATED [chebi]
synonym: "cloruro de hidrogeno" RELATED [chebi]
synonym: "HCl" RELATED [kegg.compound]
synonym: "hydrochloric acid" RELATED [chemidplus]
synonym: "Hydrochloride" RELATED [kegg.compound]
synonym: "Hydrogen chloride" RELATED [kegg.compound]
synonym: "Hydrogenchlorid" RELATED [chebi]
synonym: "Wasserstoffchlorid" RELATED [chebi]
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:18140 ! hydrogen halide
is_a: CHEBI:23117 ! chlorine molecular entity
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018033 CHEBI:50315 ! chloronium
relationship: RO:0018034 CHEBI:17996 ! chloride

[Term]
id: CHEBI:17891
name: donor
namespace: chebi_ontology
alt_id: CHEBI:14202
alt_id: CHEBI:4697
def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." []
subset: 3:STAR
subset: 3_STAR
synonym: "Donator" RELATED [ChEBI]
synonym: "Donator" RELATED [chebi]
synonym: "donneur" RELATED [chebi]
synonym: "donneur" RELATED [ChEBI]
synonym: "Donor" EXACT [KEGG_COMPOUND]
synonym: "Donor" RELATED [kegg.compound]
xref: KEGG:C01351
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:17925
name: alpha-D-glucose
namespace: chebi_ontology
alt_id: CHEBI:10242
alt_id: CHEBI:12318
alt_id: CHEBI:22386
alt_id: CHEBI:40557
alt_id: CHEBI:42802
def: "<small>D</small>-Glucopyranose having α-configuration at the anomeric centre." []
subset: 3:STAR
synonym: "alpha-D-Glc" RELATED [chebi]
synonym: "ALPHA-D-GLUCOSE" RELATED [pdb-ccd]
synonym: "alpha-D-Glucose" RELATED [kegg.compound]
synonym: "alpha-D-glucose" RELATED [uniprot_ft]
synonym: "alpha-dextrose" RELATED [chemidplus]
is_a: CHEBI:4167 ! D-glucopyranose
relationship: RO:0018039 CHEBI:37630 ! alpha-L-glucose

[Term]
id: CHEBI:17996
name: chloride
namespace: chebi_ontology
alt_id: CHEBI:13291
alt_id: CHEBI:13970
alt_id: CHEBI:3616
alt_id: CHEBI:3731
alt_id: CHEBI:48804
def: "A halide anion formed when chlorine picks up an electron to form an an anion." []
subset: 3:STAR
synonym: "Chloride" EXACT [KEGG_COMPOUND]
synonym: "Chloride" RELATED [kegg.compound]
synonym: "chloride" EXACT [UniProt]
synonym: "chloride" RELATED [uniprot_ft]
synonym: "CHLORIDE ION" RELATED [pdb-ccd]
synonym: "Chloride ion" RELATED [kegg.compound]
synonym: "Chloride(1-)" RELATED [chemidplus]
synonym: "Chlorine anion" RELATED [nist]
synonym: "Cl(-)" RELATED [iupac]
synonym: "Cl-" RELATED [kegg.compound]
is_a: CHEBI:16042 ! halide anion
is_a: CHEBI:33432 ! monoatomic chlorine
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:17883 ! hydrogen chloride

[Term]
id: CHEBI:18059
name: lipid
namespace: chebi_ontology
alt_id: CHEBI:14517
alt_id: CHEBI:25054
alt_id: CHEBI:6486
def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." []
subset: 3:STAR
synonym: "Lipid" RELATED [kegg.compound]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:18133
name: hexose
namespace: chebi_ontology
alt_id: CHEBI:14399
alt_id: CHEBI:24590
alt_id: CHEBI:5709
def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." []
subset: 3:STAR
synonym: "Hexose" RELATED [kegg.compound]
synonym: "hexoses" RELATED [chebi]
is_a: CHEBI:35381 ! monosaccharide

[Term]
id: CHEBI:18140
name: hydrogen halide
namespace: chebi_ontology
alt_id: CHEBI:13368
alt_id: CHEBI:37140
alt_id: CHEBI:5599
subset: 3:STAR
synonym: "hydrogen halide" RELATED [iupac]
synonym: "hydrogen halides" EXACT [ChEBI]
synonym: "hydrogen halides" RELATED [chebi]
is_a: CHEBI:33405 ! hydracid
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid

[Term]
id: CHEBI:18154
name: polysaccharide
namespace: chebi_ontology
alt_id: CHEBI:14864
alt_id: CHEBI:26205
alt_id: CHEBI:8322
def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." []
subset: 3:STAR
synonym: "Glycan" RELATED [kegg.compound]
synonym: "Glycane" RELATED [chebi]
synonym: "glycans" RELATED [iupac]
synonym: "Glykan" RELATED [chebi]
synonym: "Glykane" RELATED [chebi]
synonym: "polisacarido" RELATED [chebi]
synonym: "polisacaridos" RELATED [iupac]
synonym: "Polysaccharide" RELATED [kegg.compound]
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:167559 ! glycan
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:18208
name: benzylpenicillin
namespace: chebi_ontology
alt_id: CHEBI:14743
alt_id: CHEBI:25866
alt_id: CHEBI:45073
alt_id: CHEBI:7962
def: "A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [chebi]
synonym: "6-(2-phenylacetamido)penicillanic acid" RELATED [chemidplus]
synonym: "bensylpenicillin" RELATED [chebi]
synonym: "benzyl benicillin" RELATED [chebi]
synonym: "Benzylpenicillin" RELATED [kegg.compound]
synonym: "benzylpenicillinic acid" RELATED [chemidplus]
synonym: "free penicillin II" RELATED [chemidplus]
synonym: "PCG" RELATED [chebi]
synonym: "PENICILLIN G" RELATED [pdb-ccd]
synonym: "Penicillin G" RELATED [kegg.compound]
synonym: "PG" RELATED [chebi]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:53000 ! has role epitope
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
relationship: RO:0018034 CHEBI:51354 ! benzylpenicillin(1-)

[Term]
id: CHEBI:18254
name: ribonucleoside
namespace: chebi_ontology
alt_id: CHEBI:13014
alt_id: CHEBI:13015
alt_id: CHEBI:13685
alt_id: CHEBI:21085
alt_id: CHEBI:26560
alt_id: CHEBI:4240
alt_id: CHEBI:8844
def: "Any nucleoside where the sugar component is <small>D</small>-ribose." []
subset: 3:STAR
synonym: "a ribonucleoside" RELATED [uniprot_ft]
synonym: "Ribonucleoside" RELATED [kegg.compound]
synonym: "ribonucleosides" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
is_a: CHEBI:47019 ! dihydroxytetrahydrofuran

[Term]
id: CHEBI:18257
name: ornithine
namespace: chebi_ontology
alt_id: CHEBI:7784
def: "An α-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5." []
subset: 3:STAR
synonym: "2,5-Diaminopentanoic acid" EXACT [KEGG_COMPOUND]
synonym: "2,5-Diaminopentanoic acid" RELATED [kegg.compound]
synonym: "2,5-Diaminovaleric acid" RELATED [kegg.compound]
synonym: "DL-Ornithine" RELATED [chemidplus]
synonym: "Orn" RELATED [iupac]
synonym: "Ornithine" EXACT [KEGG_COMPOUND]
synonym: "Ornithine" RELATED [kegg.compound]
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018033 CHEBI:46912 ! ornithinium(1+)
relationship: RO:0018034 CHEBI:32964 ! ornithinate

[Term]
id: CHEBI:18282
name: nucleobase
namespace: chebi_ontology
alt_id: CHEBI:13873
alt_id: CHEBI:25598
alt_id: CHEBI:2995
def: "That part of DNA or RNA that may be involved in pairing." []
subset: 3:STAR
subset: 3_STAR
synonym: "Base" EXACT [KEGG_COMPOUND]
synonym: "Base" RELATED [kegg.compound]
synonym: "Base" RELATED [KEGG_COMPOUND]
synonym: "nucleobases" RELATED [chebi]
synonym: "nucleobases" RELATED [ChEBI]
xref: KEGG:C00701
xref: Wikipedia:Nucleobase
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:18291
name: manganese atom
namespace: chebi_ontology
alt_id: CHEBI:13382
alt_id: CHEBI:25153
alt_id: CHEBI:6681
subset: 3:STAR
synonym: "25Mn" RELATED [iupac]
synonym: "Mangan" RELATED [nist]
synonym: "Manganese" EXACT [KEGG_COMPOUND]
synonym: "Manganese" RELATED [kegg.compound]
synonym: "manganese" RELATED [chebi]
synonym: "manganeso" RELATED [chebi]
synonym: "manganum" RELATED [chebi]
synonym: "Mn" RELATED [iupac, uniprot_ft]
is_a: CHEBI:33352 ! manganese group element atom
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite

[Term]
id: CHEBI:18310
name: alkane
namespace: chebi_ontology
alt_id: CHEBI:13435
alt_id: CHEBI:22317
alt_id: CHEBI:2576
def: "An acyclic branched or unbranched hydrocarbon having the general formula C<small><sub><em>n</em></sub></small>H<small><sub>2<em>n</em>+2</sub></small>, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." []
subset: 3:STAR
synonym: "alcane" RELATED [iupac]
synonym: "alcanes" RELATED [iupac]
synonym: "alcano" RELATED [iupac]
synonym: "alcanos" RELATED [iupac]
synonym: "Alkan" RELATED [chebi]
synonym: "Alkane" EXACT [KEGG_COMPOUND]
synonym: "Alkane" RELATED [kegg.compound]
synonym: "an alkane" RELATED [uniprot_ft]
synonym: "RH" RELATED [kegg.compound]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:33653 ! aliphatic compound

[Term]
id: CHEBI:18320
name: 1,4-dithiothreitol
namespace: chebi_ontology
alt_id: CHEBI:11174
alt_id: CHEBI:23854
alt_id: CHEBI:4664
def: "The <i>threo</i>-diastereomer of 1,4-dimercaptobutane-2,3-diol." []
subset: 3:STAR
synonym: "(R*,R*)-1,4-dimercapto-2,3-butanediol" RELATED [nist]
synonym: "1,4-Dithiothreitol" RELATED [kegg.compound]
synonym: "1,4-dithiothreitol" RELATED [uniprot_ft]
synonym: "Cleland's reagent" RELATED [nist]
synonym: "Dithiothreitol" RELATED [kegg.compound]
synonym: "Dithiotreitol" RELATED [chemidplus]
synonym: "DL-threo-1,4-Dimercapto-2,3-butanediol" RELATED [chemidplus]
synonym: "DTL" RELATED [chebi]
synonym: "DTT" RELATED [chebi]
synonym: "rac-Dithiothreitol" RELATED [chemidplus]
synonym: "threo-1,4-Dimercapto-2,3-butanediol" RELATED [kegg.compound]
is_a: CHEBI:23853 ! dithiol
is_a: CHEBI:25189 ! 1,4-dimercaptobutane-2,3-diol
relationship: RO:0000087 CHEBI:38161 ! has role chelator
relationship: RO:0000087 CHEBI:63247 ! has role reducing agent
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:18367
name: phosphate(3-)
namespace: chebi_ontology
alt_id: CHEBI:14791
alt_id: CHEBI:45024
alt_id: CHEBI:7793
def: "A phosphate ion that is the conjugate base of hydrogenphosphate." []
subset: 3:STAR
synonym: "[PO4](3-)" RELATED [iupac]
synonym: "Orthophosphate" RELATED [kegg.compound]
synonym: "Phosphate" EXACT [KEGG_COMPOUND]
synonym: "Phosphate" RELATED [kegg.compound]
synonym: "PHOSPHATE ION" RELATED [pdb-ccd]
synonym: "PO4(3-)" RELATED [iupac]
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79387 ! trivalent inorganic anion
relationship: RO:0018033 CHEBI:43474 ! hydrogenphosphate

[Term]
id: CHEBI:18375
name: nucleoside 3',5'-cyclic phosphate
namespace: chebi_ontology
alt_id: CHEBI:1331
alt_id: CHEBI:14672
alt_id: CHEBI:19833
def: "A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-3 and C-5 of the ribose ring are engaged in formation of a cyclic mono-, di-, tri- or tetra-phosphate." []
subset: 3:STAR
synonym: "nucleoside 3',5'-cyclic phosphates" RELATED [chebi]
is_a: CHEBI:23447 ! cyclic nucleotide
relationship: RO:0018034 CHEBI:58464 ! nucleoside 3',5'-cyclic phosphate anion

[Term]
id: CHEBI:18379
name: nitrile
namespace: chebi_ontology
alt_id: CHEBI:13212
alt_id: CHEBI:13426
alt_id: CHEBI:13660
alt_id: CHEBI:25547
alt_id: CHEBI:29349
alt_id: CHEBI:7584
def: "A compound having the structure RC≡N; thus a <em>C</em>-substituted derivative of hydrocyanic acid, HC≡N. In systematic nomenclature, the suffix nitrile denotes the triply bound ≡N atom, not the carbon atom attached to it." []
subset: 3:STAR
synonym: "a nitrile" RELATED [uniprot_ft]
synonym: "Nitril" RELATED [chebi]
synonym: "Nitrile" RELATED [kegg.compound]
synonym: "nitrile" RELATED [iupac]
synonym: "nitrilos" RELATED [iupac]
synonym: "R-CN" RELATED [kegg.compound]
is_a: CHEBI:23424 ! cyanides
relationship: BFO:0000051 CHEBI:48819 ! has part cyano group

[Term]
id: CHEBI:18407
name: hydrogen cyanide
namespace: chebi_ontology
alt_id: CHEBI:13362
alt_id: CHEBI:5786
def: "A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom" []
subset: 3:STAR
synonym: "[CHN]" RELATED [iupac]
synonym: "Blausaeure" RELATED [chebi]
synonym: "Cyanwasserstoff" RELATED [nist]
synonym: "formonitrile" RELATED [iupac]
synonym: "HCN" RELATED [kegg.compound]
synonym: "hydrocyanic acid" RELATED [nist]
synonym: "Hydrogen cyanide" RELATED [kegg.compound]
synonym: "hydrogen cyanide" RELATED [iupac, uniprot_ft]
is_a: CHEBI:33405 ! hydracid
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0000087 CHEBI:64909 ! has role poison
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:17514 ! cyanide
relationship: RO:0018036 CHEBI:36856 ! hydrogen isocyanide

[Term]
id: CHEBI:184376
name: streptidine(2+)
namespace: chebi_ontology
def: "A guanidinium ion obtained by protonation of both guanidino groups of streptidine; major species at pH 7.3." []
subset: 3:STAR
synonym: "streptidine" RELATED [uniprot_ft]
synonym: "streptidine dication" RELATED [chebi]
synonym: "{[(1R,2s,3S,4R,5r,6S)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diazanediyl}bis(aminomethaniminium)" RELATED [iupac]
is_a: CHEBI:60251 ! guanidinium ion
relationship: RO:0018034 CHEBI:27405 ! streptidine

[Term]
id: CHEBI:184381
name: bacitracin A zwitterion
namespace: chebi_ontology
subset: 2:STAR
synonym: "bacitracin A" RELATED [uniprot_ft]
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:28669 ! bacitracin

[Term]
id: CHEBI:18946
name: delta-lactone
namespace: chebi_ontology
def: "A lactone having a six-membered lactone ring." []
subset: 3:STAR
synonym: "1,5-lactone" RELATED [chebi]
synonym: "1,5-lactones" RELATED [chebi]
synonym: "delta-lactona" RELATED [chebi]
synonym: "delta-lactonas" RELATED [chebi]
synonym: "delta-lactone" RELATED [chebi]
synonym: "delta-lactones" RELATED [chebi]
is_a: CHEBI:25000 ! lactone

[Term]
id: CHEBI:190303
name: inorganic potassium salt
namespace: chebi_ontology
def: "A potassium salt that lacks C-H bonds" []
subset: 2:STAR
is_a: CHEBI:167164 ! mineral nutrient
is_a: CHEBI:24839 ! inorganic salt
is_a: CHEBI:26218 ! potassium salt

[Term]
id: CHEBI:190509
name: imipenem zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of imipenem having an anionic carboxy group and a protonated methaneimidamido group; major species at pH 7.3." []
subset: 3:STAR
synonym: "imipenem" RELATED [uniprot_ft]
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:471744 ! imipenem

[Term]
id: CHEBI:19129
name: 11alpha-hydroxy steroid
namespace: chebi_ontology
subset: 3:STAR
synonym: "11alpha-hydroxy steroids" RELATED [chebi]
synonym: "a 11-alpha-hydroxy steroid" RELATED [uniprot_ft]
is_a: CHEBI:36841 ! 11-hydroxy steroid

[Term]
id: CHEBI:192484
name: ciprofloxacin zwitterion
namespace: chebi_ontology
def: "A zwitterion formed from ciprofloxacin by transfer of a proton from the carboxy to the amino group; major species at pH 7.3." []
subset: 3:STAR
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:100241 ! ciprofloxacin

[Term]
id: CHEBI:192486
name: ciprofloxacin(1+)
namespace: chebi_ontology
def: "A secondary ammonium ion that is the conjugate acid of ciprofloxacin resulting from the protonation of the NH group; major species at acidic pH." []
subset: 3:STAR
synonym: "ciprofloxacin cation" RELATED [chebi]
is_a: CHEBI:137419 ! secondary ammonium ion
relationship: RO:0018034 CHEBI:100241 ! ciprofloxacin

[Term]
id: CHEBI:192979
name: nystatin A2
namespace: chebi_ontology
subset: 3:STAR
synonym: "nystatin A2" RELATED [chemidplus]
is_a: CHEBI:59676 ! nystatins

[Term]
id: CHEBI:194135
name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
namespace: chebi_ontology
def: "An oxazinoquinoline that is 2,3-dihydro-7<em>H</em>-[1,4]oxazino[2,3,4-<em>ij</em>]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively." []
subset: 3:STAR
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:46920 ! N-methylpiperazine
is_a: CHEBI:47881 ! 3-oxo monocarboxylic acid
is_a: CHEBI:53665 ! oxazinoquinoline

[Term]
id: CHEBI:19834
name: 3',5'-cyclic purine nucleotide
namespace: chebi_ontology
subset: 3:STAR
synonym: "3',5'-cyclic purine nucleotides" RELATED [chebi]
is_a: CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate
is_a: CHEBI:36982 ! cyclic purine nucleotide

[Term]
id: CHEBI:204928
name: cefotaxime
namespace: chebi_ontology
alt_id: CHEBI:112504
alt_id: CHEBI:3497
alt_id: CHEBI:41475
def: "A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups." []
subset: 3:STAR
synonym: "(6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "(6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [chembl]
synonym: "(6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [chembl]
synonym: "Cephotaxime" RELATED [chemidplus]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:36816 ! oxime O-ether
is_a: CHEBI:38418 ! 1,3-thiazoles
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:53670 ! cefotaxime(1-)

[Term]
id: CHEBI:20854
name: ATP synthase inhibitor
namespace: chebi_ontology
def: "A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase." []
subset: 3:STAR
is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor
is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor

[Term]
id: CHEBI:209807
name: cefoxitin
namespace: chebi_ontology
alt_id: CHEBI:3500
alt_id: CHEBI:41436
alt_id: CHEBI:471714
alt_id: CHEBI:658070
def: "A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7α position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to β-lactamase." []
subset: 3:STAR
synonym: "(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "Cefoxitin" RELATED [chemidplus]
synonym: "Cephoxitin" RELATED [chemidplus]
synonym: "CFX" RELATED [kegg.drug]
synonym: "Rephoxitin" RELATED [chemidplus]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:55429 ! cephamycin
is_a: CHEBI:72588 ! semisynthetic derivative
is_a: CHEBI:88225 ! beta-lactam antibiotic allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:53655 ! cefoxitin(1-)

[Term]
id: CHEBI:21638
name: N-acylglucosamine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-acylglucosamine" RELATED [chebi]
synonym: "N-acylglucosamines" RELATED [chebi]
is_a: CHEBI:21656 ! N-acyl-hexosamine
is_a: CHEBI:24271 ! glucosamines

[Term]
id: CHEBI:21656
name: N-acyl-hexosamine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-acyl-hexosamine" RELATED [chebi]
synonym: "N-acyl-hexosamines" RELATED [chebi]
is_a: CHEBI:24586 ! hexosamine

[Term]
id: CHEBI:21731
name: N-glycosyl compound
namespace: chebi_ontology
def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." []
subset: 3:STAR
synonym: "glycosylamines" RELATED [iupac]
synonym: "N-glycoside" RELATED [chebi]
synonym: "N-glycosides" RELATED [chebi]
synonym: "N-glycosyl compounds" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:63161 ! glycosyl compound

[Term]
id: CHEBI:22153
name: acaricide
namespace: chebi_ontology
def: "A substance used to destroy pests of the subclass <em>Acari</em> (mites and ticks)." []
subset: 3:STAR
synonym: "acaricides" RELATED [chebi]
synonym: "Akarizid" RELATED [chebi]
synonym: "Akarizide" RELATED [chebi]
synonym: "miticide" RELATED [chebi]
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:22160
name: acetamides
namespace: chebi_ontology
def: "Compounds with the general formula RNHC(=O)CH<small><sub>3</sub></small>." []
subset: 3:STAR
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:22221
name: acyl group
namespace: chebi_ontology
def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
subset: 3:STAR
subset: 3_STAR
synonym: "acyl group" EXACT [IUPAC]
synonym: "acyl group" RELATED [iupac]
synonym: "acyl groups" RELATED [chebi]
synonym: "acyl groups" RELATED [ChEBI]
synonym: "alkanoyl group" RELATED [chebi]
synonym: "alkanoyl group" RELATED [ChEBI]
synonym: "groupe acyle" RELATED [iupac]
synonym: "groupe acyle" RELATED [IUPAC]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:22314
name: alkali metal atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "alkali metal" RELATED [chebi]
synonym: "Alkalimetall" RELATED [chebi]
synonym: "Alkalimetalle" RELATED [chebi]
synonym: "metal alcalin" RELATED [chebi]
synonym: "metal alcalino" RELATED [chebi]
synonym: "metales alcalinos" RELATED [chebi]
synonym: "metaux alcalins" RELATED [chebi]
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:22315
name: alkaloid
namespace: chebi_ontology
def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." []
subset: 3:STAR
synonym: "alcaloide" RELATED [chebi]
synonym: "alcaloides" RELATED [chebi]
synonym: "Alkaloid" RELATED [chebi]
synonym: "Alkaloide" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:25212 ! has role metabolite

[Term]
id: CHEBI:22323
name: alkyl group
namespace: chebi_ontology
def: "A univalent group ‒C<small><sub><em>n</em></sub></small>H<small><sub>2<em>n</em>+1</sub></small> derived from an alkane by removal of a hydrogen atom from any carbon atom." []
subset: 3:STAR
synonym: "groupe alkyle" RELATED [iupac]
synonym: "grupo alquilo" RELATED [iupac]
synonym: "grupos alquilo" RELATED [iupac]
is_a: CHEBI:33248 ! hydrocarbyl group
relationship: RO:0018037 CHEBI:18310 ! alkane

[Term]
id: CHEBI:22390
name: alpha-D-glucoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "alpha-D-glucoside" RELATED [chebi]
synonym: "alpha-D-glucosides" RELATED [chebi]
synonym: "an alpha-D-glucoside" RELATED [uniprot_ft]
is_a: CHEBI:35436 ! D-glucoside
is_a: CHEBI:60979 ! alpha-glucoside
relationship: RO:0018038 CHEBI:17925 ! alpha-D-glucose

[Term]
id: CHEBI:22478
name: amino alcohol
namespace: chebi_ontology
def: "An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group." []
subset: 3:STAR
synonym: "amino alcohols" RELATED [chebi]
synonym: "aminoalcohol" RELATED [chebi]
synonym: "aminoalcohols" RELATED [chebi]
is_a: CHEBI:30879 ! alcohol
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:22479
name: amino cyclitol glycoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "amino cyclitol glycoside" RELATED [chebi]
synonym: "amino cyclitol glycosides" RELATED [chebi]
is_a: CHEBI:23451 ! cyclitol
is_a: CHEBI:24400 ! glycoside

[Term]
id: CHEBI:22494
name: aminobenzoate
namespace: chebi_ontology
subset: 3:STAR
synonym: "aminobenzoates" RELATED [chebi]
is_a: CHEBI:22718 ! benzoates
relationship: RO:0018033 CHEBI:22495 ! aminobenzoic acid

[Term]
id: CHEBI:22495
name: aminobenzoic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "Aminobenzoesaeure" RELATED [chebi]
is_a: CHEBI:22723 ! benzoic acids
is_a: CHEBI:33856 ! aromatic amino acid
relationship: RO:0018034 CHEBI:22494 ! aminobenzoate

[Term]
id: CHEBI:22506
name: aminoglycan
namespace: chebi_ontology
subset: 3:STAR
synonym: "aminoglycans" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:65212 ! polysaccharide derivative

[Term]
id: CHEBI:22507
name: aminoglycoside antibiotic
namespace: chebi_ontology
subset: 3:STAR
synonym: "aminoglycoside antibiotics" RELATED [chebi]
is_a: CHEBI:23007 ! carbohydrate-containing antibiotic
is_a: CHEBI:47779 ! aminoglycoside

[Term]
id: CHEBI:22562
name: anilines
namespace: chebi_ontology
def: "Any  aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33860 ! aromatic amine

[Term]
id: CHEBI:22563
name: anion
namespace: chebi_ontology
def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." []
subset: 3:STAR
subset: 3_STAR
synonym: "Anion" EXACT [ChEBI]
synonym: "Anion" RELATED [chebi]
synonym: "anion" EXACT [ChEBI]
synonym: "anion" RELATED [chebi]
synonym: "Anionen" RELATED [ChEBI]
synonym: "Anionen" RELATED [chebi]
synonym: "aniones" RELATED [ChEBI]
synonym: "aniones" RELATED [chebi]
synonym: "anions" RELATED [IUPAC]
synonym: "anions" RELATED [iupac]
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:22565
name: ansamycin
namespace: chebi_ontology
def: "A class of macrocyclic lactams that consist of an aromatic (phenyl or naphthyl) or quinonoid (benzoquinone or naphthoquinone) moiety that is bridged by an aliphatic chain." []
subset: 3:STAR
is_a: CHEBI:24995 ! lactam
is_a: CHEBI:26188 ! polyketide
is_a: CHEBI:51026 ! macrocycle

[Term]
id: CHEBI:22586
name: antioxidant
namespace: chebi_ontology
def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." []
subset: 3:STAR
synonym: "antioxidants" RELATED [chebi]
synonym: "antioxydant" RELATED [chebi]
synonym: "antoxidant" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:22587
name: antiviral agent
namespace: chebi_ontology
def: "A substance that destroys or inhibits replication of viruses." []
subset: 3:STAR
synonym: "anti-viral agent" RELATED [chebi]
synonym: "anti-viral agents" RELATED [chebi]
synonym: "antiviral" RELATED [chebi]
synonym: "antiviral agents" RELATED [chebi]
synonym: "antivirals" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:22601
name: arabinoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "arabinoside" RELATED [chebi]
synonym: "arabinosides" RELATED [chebi]
is_a: CHEBI:35312 ! pentoside

[Term]
id: CHEBI:22645
name: arenecarboxamide
namespace: chebi_ontology
def: "A monocarboxylic acid amide in which the amide linkage is bonded directly to an arene ring system." []
subset: 3:STAR
synonym: "arenecarboxamides" RELATED [chebi]
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:62733 ! aromatic amide

[Term]
id: CHEBI:22695
name: base
namespace: chebi_ontology
def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." []
subset: 3:STAR
subset: 3_STAR
synonym: "Base" EXACT [ChEBI]
synonym: "Base" RELATED [chebi]
synonym: "base" EXACT [ChEBI]
synonym: "base" RELATED [chebi]
synonym: "Base1" RELATED [kegg.compound]
synonym: "Base1" RELATED [KEGG_COMPOUND]
synonym: "Base2" RELATED [kegg.compound]
synonym: "Base2" RELATED [KEGG_COMPOUND]
synonym: "Basen" RELATED [ChEBI]
synonym: "Basen" RELATED [chebi]
synonym: "bases" RELATED [ChEBI]
synonym: "bases" RELATED [chebi]
synonym: "Nucleobase" RELATED [KEGG_COMPOUND]
synonym: "Nucleobase" RELATED [kegg.compound]
xref: KEGG:C00701
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:22702
name: benzamides
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:22645 ! arenecarboxamide

[Term]
id: CHEBI:22712
name: benzenes
namespace: chebi_ontology
def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound

[Term]
id: CHEBI:22713
name: arenesulfonate oxoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "arenesulfonates" RELATED [chebi]
is_a: CHEBI:33554 ! organosulfonate oxoanion
relationship: RO:0018033 CHEBI:33555 ! arenesulfonic acid

[Term]
id: CHEBI:22715
name: benzimidazoles
namespace: chebi_ontology
def: "An organic heterocyclic compound containing a benzene ring fused to an imidazole ring." []
subset: 3:STAR
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:22718
name: benzoates
namespace: chebi_ontology
def: "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid." []
subset: 3:STAR
synonym: "benzoate anion" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
is_a: CHEBI:91007 ! aromatic carboxylate

[Term]
id: CHEBI:22723
name: benzoic acids
namespace: chebi_ontology
def: "Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group." []
subset: 3:STAR
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:33859 ! aromatic carboxylic acid

[Term]
id: CHEBI:22727
name: benzopyran
namespace: chebi_ontology
subset: 3:STAR
synonym: "benzopyrans" RELATED [chebi]
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:22728
name: benzopyrrole
namespace: chebi_ontology
subset: 3:STAR
synonym: "benzopyrroles" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38180 ! polycyclic heteroarene

[Term]
id: CHEBI:228364
name: NMR chemical shift reference compound
namespace: chebi_ontology
def: "Any compound that produces a peak used as reference frequency in the delta chemical shift scale." []
subset: 3:STAR
subset: 3_STAR
synonym: "NMR chemical shift reference compounds" RELATED [chebi]
synonym: "NMR chemical shift reference compounds" RELATED [ChEBI]
synonym: "NMR chemical shift standard" RELATED [chebi]
synonym: "NMR chemical shift standard" RELATED [ChEBI]
synonym: "NMR chemical shift standards" RELATED [ChEBI]
synonym: "NMR chemical shift standards" RELATED [chebi]
synonym: "NMR internal standard" RELATED [chebi]
synonym: "NMR internal standard" RELATED [ChEBI]
synonym: "NMR internal standards" RELATED [chebi]
synonym: "NMR internal standards" RELATED [ChEBI]
synonym: "NMR reference standard" RELATED [ChEBI]
synonym: "NMR reference standard" RELATED [chebi]
synonym: "NMR reference standards" RELATED [ChEBI]
synonym: "NMR reference standards" RELATED [chebi]
is_a: CHEBI:747204 ! reference compound

[Term]
id: CHEBI:22888
name: biphenyls
namespace: chebi_ontology
def: "Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond." []
subset: 3:STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound
is_a: CHEBI:36820 ! ring assembly
is_a: CHEBI:64459 ! biaryl

[Term]
id: CHEBI:22907
name: bleomycin
namespace: chebi_ontology
alt_id: CHEBI:584977
def: "A glycopeptide produced by the bacterium <em>Streptomyces verticillus</em>. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A<small><sub>2</sub></small> and B<small><sub>2</sub></small>." []
subset: 3:STAR
is_a: CHEBI:23089 ! chelate-forming peptide
is_a: CHEBI:24396 ! glycopeptide

[Term]
id: CHEBI:22917
name: phytogenic insecticide
namespace: chebi_ontology
def: "An insecticide compound naturally occurring in plants." []
subset: 3:STAR
synonym: "botanical insecticide" RELATED [chebi]
synonym: "botanical insecticides" RELATED [chebi]
synonym: "phytogenic insecticides" RELATED [chebi]
is_a: CHEBI:24852 ! insecticide

[Term]
id: CHEBI:22944
name: butanediols
namespace: chebi_ontology
def: "A diol that is a butanediol or a derivative of a butanediol." []
subset: 3:STAR
is_a: CHEBI:23824 ! diol

[Term]
id: CHEBI:229543
name: sulbactam(1-)
namespace: chebi_ontology
def: "A monocarboxylic acid anion that is the conjugate base of sulbactam resulting from the deprotonation of the carboxy group; Major species at pH 7.3." []
subset: 3:STAR
synonym: "sulbactam anion" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:9321 ! sulbactam

[Term]
id: CHEBI:22986
name: calcium ionophore
namespace: chebi_ontology
subset: 3:STAR
synonym: "calcium ionophores" RELATED [chebi]
is_a: CHEBI:24869 ! ionophore

[Term]
id: CHEBI:23003
name: carbamate ester
namespace: chebi_ontology
def: "Any ester of carbamic acid or its <em>N</em>-substituted derivatives." []
subset: 3:STAR
synonym: "carbamate esters" RELATED [chebi]
synonym: "carbamates" RELATED [chebi]
is_a: CHEBI:33308 ! carboxylic ester
relationship: RO:0018038 CHEBI:28616 ! carbamic acid

[Term]
id: CHEBI:23004
name: carbamoyl group
namespace: chebi_ontology
def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "-C(O)NH2" RELATED [ChEBI]
synonym: "-C(O)NH2" RELATED [chebi]
synonym: "-CONH2" RELATED [IUPAC]
synonym: "-CONH2" RELATED [iupac]
synonym: "aminocarbonyl" RELATED [iupac]
synonym: "aminocarbonyl" RELATED [IUPAC]
synonym: "carbamyl" RELATED [chebi]
synonym: "carbamyl" RELATED [ChEBI]
synonym: "carbamyl group" RELATED [chebi]
synonym: "carbamyl group" RELATED [ChEBI]
synonym: "carboxamide" RELATED [iupac]
synonym: "carboxamide" RELATED [IUPAC]
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid
relationship: RO:0018037 CHEBI:28616 ! carbamic acid

[Term]
id: CHEBI:23007
name: carbohydrate-containing antibiotic
namespace: chebi_ontology
def: "Any carbohydrate derivative that exhibits antibiotic activity." []
subset: 3:STAR
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:23018
name: EC 4.2.1.1 (carbonic anhydrase) inhibitor
namespace: chebi_ontology
def: "An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H<small><sup>+</small></sup> ions by the proximal kidney tubule." []
subset: 3:STAR
synonym: "anhydrase inhibitor" RELATED [chebi]
synonym: "anhydrase inhibitors" RELATED [chebi]
synonym: "carbonate anhydrase inhibitor" RELATED [chebi]
synonym: "carbonate anhydrase inhibitors" RELATED [chebi]
synonym: "carbonate dehydratase inhibitor" RELATED [chebi]
synonym: "carbonate dehydratase inhibitors" RELATED [chebi]
synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitor" RELATED [chebi]
synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitors" RELATED [chebi]
synonym: "carbonate hydro-lyase inhibitor" RELATED [chebi]
synonym: "carbonate hydro-lyase inhibitors" RELATED [chebi]
synonym: "carbonic acid anhydrase inhibitor" RELATED [chebi]
synonym: "carbonic acid anhydrase inhibitors" RELATED [chebi]
synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitor" RELATED [chebi]
synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitors" RELATED [chebi]
synonym: "carbonic anhydrase A inhibitor" RELATED [chebi]
synonym: "carbonic anhydrase A inhibitors" RELATED [chebi]
synonym: "carbonic anhydrase inhibitor" RELATED [chebi]
synonym: "carbonic anhydrase inhibitors" RELATED [chebi]
synonym: "carboxyanhydrase inhibitor" RELATED [chebi]
synonym: "carboxyanhydrase inhibitors" RELATED [chebi]
synonym: "EC 4.2.1.1 (carbonic anhydrase) inhibitors" RELATED [chebi]
synonym: "EC 4.2.1.1 inhibitor" RELATED [chebi]
synonym: "EC 4.2.1.1 inhibitors" RELATED [chebi]
is_a: CHEBI:76907 ! EC 4.2.1.* (hydro-lyases) inhibitor

[Term]
id: CHEBI:23019
name: carbonyl group
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: ">C=O" RELATED [iupac]
synonym: ">C=O" RELATED [IUPAC]
synonym: "carbonyl group" EXACT [ChEBI, UniProt]
synonym: "carbonyl group" RELATED [chebi, uniprot_ft]
is_a: CHEBI:51422 ! organodiyl group

[Term]
id: CHEBI:230471
name: EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitor
namespace: chebi_ontology
def: "A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of 1,3-β-glucan synthase (EC 2.4.1.34)." []
subset: 3:STAR
synonym: "(1,3)-beta-glucan (callose) synthase inhibitor" RELATED [chebi]
synonym: "(1,3)-beta-glucan (callose) synthase inhibitors" RELATED [chebi]
synonym: "1,3-beta-D-glucan synthase inhibitor" RELATED [chebi]
synonym: "1,3-beta-D-glucan synthase inhibitors" RELATED [chebi]
synonym: "1,3-beta-D-glucan synthetase inhibitor" RELATED [chebi]
synonym: "1,3-beta-D-glucan synthetase inhibitors" RELATED [chebi]
synonym: "1,3-beta-D-glucan--UDP glucosyltransferase inhibitor" RELATED [chebi]
synonym: "1,3-beta-D-glucan--UDP glucosyltransferase inhibitors" RELATED [chebi]
synonym: "1,3-beta-D-glucan-UDP glucosyltransferase inhibitor" RELATED [chebi]
synonym: "1,3-beta-D-glucan-UDP glucosyltransferase inhibitors" RELATED [chebi]
synonym: "1,3-beta-glucan synthase inhibitor" RELATED [chebi]
synonym: "1,3-beta-glucan synthase inhibitors" RELATED [chebi]
synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase inhibitor" RELATED [chebi]
synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase inhibitors" RELATED [chebi]
synonym: "beta-1,3-glucan synthase inhibitor" RELATED [chebi]
synonym: "beta-1,3-glucan synthase inhibitors" RELATED [chebi]
synonym: "beta-1,3-glucan synthetase inhibitor" RELATED [chebi]
synonym: "beta-1,3-glucan synthetase inhibitors" RELATED [chebi]
synonym: "callose synthase inhibitor" RELATED [chebi]
synonym: "callose synthase inhibitors" RELATED [chebi]
synonym: "callose synthetase inhibitor" RELATED [chebi]
synonym: "callose synthetase inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.34 inhibitor" RELATED [chebi]
synonym: "EC 2.4.1.34 inhibitors" RELATED [chebi]
synonym: "GS-II inhibitor" RELATED [chebi]
synonym: "GS-II inhibitors" RELATED [chebi]
synonym: "paramylon synthetase inhibitor" RELATED [chebi]
synonym: "paramylon synthetase inhibitors" RELATED [chebi]
synonym: "UDP-glucose--1,3-beta-D-glucan glucosyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-glucose--1,3-beta-D-glucan glucosyltransferase inhibitors" RELATED [chebi]
synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase inhibitors" RELATED [chebi]
synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase inhibitors" RELATED [chebi]
synonym: "UDP-glucose-beta-glucan glucosyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-glucose-beta-glucan glucosyltransferase inhibitors" RELATED [chebi]
synonym: "UDP-glucose:(1,3)beta-glucan synthase inhibitor" RELATED [chebi]
synonym: "UDP-glucose:(1,3)beta-glucan synthase inhibitors" RELATED [chebi]
synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase inhibitors" RELATED [chebi]
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase inhibitor" RELATED [chebi]
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor

[Term]
id: CHEBI:23066
name: cephalosporin
namespace: chebi_ontology
alt_id: CHEBI:3538
def: "A class of β-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring.  Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy." []
subset: 3:STAR
synonym: "cephalosphorin" RELATED [chebi]
synonym: "cephalosphorins" RELATED [chebi]
synonym: "Cephalosporin" RELATED [kegg.compound]
synonym: "cephalosporins" RELATED [chebi]
is_a: CHEBI:38311 ! cephem
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen

[Term]
id: CHEBI:23089
name: chelate-forming peptide
namespace: chebi_ontology
subset: 1:STAR
synonym: "chelate-forming peptides" RELATED [chebi]
is_a: CHEBI:25903 ! peptide antibiotic
relationship: RO:0000087 CHEBI:38161 ! has role chelator

[Term]
id: CHEBI:23114
name: chloride salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "chloride salts" RELATED [chebi]
synonym: "chlorides" RELATED [chebi]
is_a: CHEBI:23117 ! chlorine molecular entity
is_a: CHEBI:33958 ! halide salt
relationship: BFO:0000051 CHEBI:17996 ! has part chloride

[Term]
id: CHEBI:23116
name: chlorine atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "17Cl" RELATED [iupac]
synonym: "Chlor" RELATED [chebi]
synonym: "chlore" RELATED [chebi]
synonym: "chlorine" RELATED [chebi]
synonym: "chlorum" RELATED [chebi]
synonym: "Cl" RELATED [iupac]
synonym: "cloro" RELATED [chebi]
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient

[Term]
id: CHEBI:23117
name: chlorine molecular entity
namespace: chebi_ontology
def: "A halogen molecular entity containing one or more atoms of chlorine." []
subset: 3:STAR
is_a: CHEBI:24471 ! halogen molecular entity
relationship: BFO:0000051 CHEBI:23116 ! has part chlorine atom

[Term]
id: CHEBI:23132
name: chlorobenzenes
namespace: chebi_ontology
def: "Any organochlorine compound containing a benzene ring which is substituted by one or more chlorines." []
subset: 3:STAR
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:36683 ! organochlorine compound

[Term]
id: CHEBI:231550
name: azithromycin(2+)
namespace: chebi_ontology
def: "A tertiary ammonium ion resulting from the protonation of the two amino groups of azithromycin; major species at pH 7.3." []
subset: 3:STAR
synonym: "azithromycin dication" RELATED [chebi]
is_a: CHEBI:137982 ! tertiary ammonium ion
relationship: RO:0018034 CHEBI:2955 ! azithromycin

[Term]
id: CHEBI:231553
name: levofloxacin(1-)
namespace: chebi_ontology
def: "An oxo monocarboxylic acid anion that is the conjugate base of levofloxacin resulting from the deprotonation of the carboxy group; major species at pH 7.3." []
subset: 3:STAR
synonym: "levofloxacin anion" RELATED [chebi]
is_a: CHEBI:35902 ! oxo monocarboxylic acid anion
relationship: RO:0018033 CHEBI:63598 ! levofloxacin

[Term]
id: CHEBI:23213
name: choline ester
namespace: chebi_ontology
alt_id: CHEBI:3666
subset: 3:STAR
synonym: "choline esters" RELATED [chebi]
is_a: CHEBI:35701 ! ester
relationship: RO:0018038 CHEBI:15354 ! choline

[Term]
id: CHEBI:23217
name: cholines
namespace: chebi_ontology
def: "A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof." []
subset: 3:STAR
is_a: CHEBI:35267 ! quaternary ammonium ion

[Term]
id: CHEBI:23232
name: chromenes
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:38443 ! 1-benzopyran

[Term]
id: CHEBI:23239
name: chromopeptide
namespace: chebi_ontology
subset: 1:STAR
synonym: "chromopeptides" RELATED [chebi]
is_a: CHEBI:25903 ! peptide antibiotic

[Term]
id: CHEBI:233202
name: paromomycin(5+)
namespace: chebi_ontology
subset: 2:STAR
synonym: "paromomycin" RELATED [uniprot_ft]
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:7934 ! paromomycin

[Term]
id: CHEBI:23357
name: cofactor
namespace: chebi_ontology
def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." []
subset: 3:STAR
subset: 3_STAR
synonym: "cofactor" EXACT [IUPAC]
synonym: "cofactor" RELATED [iupac]
xref: Wikipedia:Cofactor_(biochemistry)
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:23366
name: compatible osmolytes
namespace: chebi_ontology
subset: 1:STAR
synonym: "compatible osmolytes" RELATED [chebi]
is_a: CHEBI:25728 ! osmolyte

[Term]
id: CHEBI:23367
name: molecular entity
namespace: chebi_ontology
def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." []
subset: 3:STAR
subset: 3_STAR
synonym: "entidad molecular" RELATED [iupac]
synonym: "entidad molecular" RELATED [IUPAC]
synonym: "entidades moleculares" RELATED [iupac]
synonym: "entidades moleculares" RELATED [IUPAC]
synonym: "entite moleculaire" RELATED [iupac]
synonym: "entite moleculaire" RELATED [IUPAC]
synonym: "molecular entities" RELATED [iupac]
synonym: "molecular entities" RELATED [IUPAC]
synonym: "molekulare Entitaet" RELATED [chebi]
synonym: "molekulare Entitaet" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:23377
name: copper molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "copper compounds" RELATED [chebi]
synonym: "copper molecular entities" RELATED [chebi]
synonym: "copper molecular entity" RELATED [chebi]
is_a: CHEBI:33745 ! copper group molecular entity
relationship: BFO:0000051 CHEBI:28694 ! has part copper atom

[Term]
id: CHEBI:23378
name: copper cation
namespace: chebi_ontology
subset: 3:STAR
synonym: "copper cations" RELATED [chebi]
synonym: "Cu cation" RELATED [uniprot_ft]
is_a: CHEBI:33515 ! transition element cation
is_a: CHEBI:37404 ! elemental copper
relationship: RO:0000087 CHEBI:23357 ! has role cofactor

[Term]
id: CHEBI:23403
name: coumarins
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:26004 ! phenylpropanoid
is_a: CHEBI:38445 ! chromenone

[Term]
id: CHEBI:23414
name: copper(II) sulfate
namespace: chebi_ontology
def: "A metal sulfate compound having copper(2+) as the metal ion." []
subset: 3:STAR
synonym: "copper sulfate" RELATED [chemidplus]
synonym: "Copper(II) sulfate" RELATED [kegg.compound]
synonym: "Cupric sulfate" RELATED [chemidplus]
synonym: "cupric sulfate anhydrous" RELATED [chemidplus]
synonym: "CuSO4" RELATED [iupac]
is_a: CHEBI:51336 ! metal sulfate
relationship: BFO:0000051 CHEBI:29036 ! has part copper(2+)
relationship: RO:0000087 CHEBI:139492 ! has role sensitiser
relationship: RO:0000087 CHEBI:149552 ! has role emetic
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer

[Term]
id: CHEBI:23424
name: cyanides
namespace: chebi_ontology
def: "Salts and <em>C</em>-organyl derivatives of hydrogen cyanide, HC≡N." []
subset: 3:STAR
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0018040 CHEBI:18407 ! hydrogen cyanide

[Term]
id: CHEBI:23443
name: cyclic amide
namespace: chebi_ontology
alt_id: CHEBI:3990
subset: 3:STAR
synonym: "cyclic amide" RELATED [chebi]
synonym: "cyclic amides" RELATED [chebi]
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:23447
name: cyclic nucleotide
namespace: chebi_ontology
subset: 3:STAR
synonym: "cyclic nucleotides" RELATED [chebi]
is_a: CHEBI:36976 ! nucleotide

[Term]
id: CHEBI:23449
name: cyclic peptide
namespace: chebi_ontology
subset: 3:STAR
synonym: "cyclic peptides" RELATED [chebi]
synonym: "Cyclopeptid" RELATED [chebi]
synonym: "peptide cyclique" RELATED [iupac]
synonym: "peptido ciclico" RELATED [iupac]
synonym: "Zyklopeptid" RELATED [chebi]
is_a: CHEBI:16670 ! peptide

[Term]
id: CHEBI:23451
name: cyclitol
namespace: chebi_ontology
def: "A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom." []
subset: 3:STAR
is_a: CHEBI:26191 ! polyol

[Term]
id: CHEBI:23503
name: 4-amino-1,2-oxazolidin-3-one
namespace: chebi_ontology
def: "A member of the class of oxazolidines that is isoxazoldin-3-one which is substituted at position 4 by an amino group." []
subset: 3:STAR
synonym: "cycloserine" RELATED [chebi]
is_a: CHEBI:26649 ! serine derivative
is_a: CHEBI:38329 ! oxazolidines
is_a: CHEBI:50994 ! primary amino compound
is_a: CHEBI:75606 ! hydroxamic acid ester

[Term]
id: CHEBI:23636
name: deoxyribonucleoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "deoxyribonucleosides" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside

[Term]
id: CHEBI:23643
name: depsipeptide
namespace: chebi_ontology
def: "A natural or synthetic compound having a sequence of amino and hydroxy carboxylic acid residues (usually α-amino and α-hydroxy acids), commonly but not necessarily regularly alternating." []
subset: 3:STAR
synonym: "Depsipeptid" RELATED [chebi]
is_a: CHEBI:16670 ! peptide

[Term]
id: CHEBI:23666
name: diamine
namespace: chebi_ontology
def: "Any polyamine that contains two amino groups." []
subset: 3:STAR
is_a: CHEBI:88061 ! polyamine

[Term]
id: CHEBI:23677
name: diazole
namespace: chebi_ontology
def: "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." []
subset: 3:STAR
synonym: "diazoles" RELATED [chebi]
is_a: CHEBI:68452 ! azole

[Term]
id: CHEBI:23697
name: dichlorobenzene
namespace: chebi_ontology
def: "Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions." []
subset: 3:STAR
synonym: "Dichlorbenzol" RELATED [chebi]
synonym: "dichlorobenzene" RELATED [chebi]
synonym: "dichlorobenzenes" RELATED [chebi]
is_a: CHEBI:23132 ! chlorobenzenes

[Term]
id: CHEBI:23763
name: pyrroline
namespace: chebi_ontology
def: "Any organic heteromonocyclic compound with a structure based on a dihydropyrrole." []
subset: 3:STAR
synonym: "dihydropyrrole" RELATED [chemidplus]
synonym: "pyrroline" RELATED [chemidplus]
synonym: "pyrrolines" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:23765
name: quinolone
namespace: chebi_ontology
subset: 3:STAR
synonym: "quinolones" RELATED [chebi]
is_a: CHEBI:26513 ! quinolines

[Term]
id: CHEBI:23824
name: diol
namespace: chebi_ontology
def: "A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols." []
subset: 3:STAR
is_a: CHEBI:26191 ! polyol

[Term]
id: CHEBI:23849
name: diterpenoid
namespace: chebi_ontology
def: "Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." []
subset: 3:STAR
synonym: "C20 isoprenoids" RELATED [lipidmaps]
synonym: "diterpenoides" RELATED [chebi]
is_a: CHEBI:26873 ! terpenoid
relationship: RO:0018040 CHEBI:35190 ! diterpene

[Term]
id: CHEBI:23853
name: dithiol
namespace: chebi_ontology
subset: 3:STAR
synonym: "dithiols" RELATED [chebi]
is_a: CHEBI:29256 ! thiol

[Term]
id: CHEBI:23870
name: dodecyl group
namespace: chebi_ontology
subset: 3:STAR
synonym: "CH3-[CH2]11-" RELATED [iupac]
synonym: "Dod" RELATED [iubmb]
synonym: "dodecan-1-yl" RELATED [chebi]
synonym: "lauryl" RELATED [chebi]
is_a: CHEBI:22323 ! alkyl group
relationship: RO:0018037 CHEBI:28817 ! dodecane

[Term]
id: CHEBI:23872
name: dodecyl sulfate
namespace: chebi_ontology
subset: 3:STAR
synonym: "dodecyl sulfate" RELATED [uniprot_ft]
is_a: CHEBI:58958 ! organosulfate oxoanion
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0018033 CHEBI:45599 ! dodecyl hydrogen sulfate

[Term]
id: CHEBI:23888
name: drug
namespace: chebi_ontology
def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." []
subset: 3:STAR
synonym: "drugs" RELATED [chebi]
synonym: "medicine" RELATED [chebi]
is_a: CHEBI:52217 ! pharmaceutical

[Term]
id: CHEBI:23905
name: monoatomic anion
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoatomic anions" RELATED [chebi]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:24867 ! monoatomic ion

[Term]
id: CHEBI:23906
name: monoatomic cation
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoatomic cations" RELATED [chebi]
is_a: CHEBI:24867 ! monoatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:23924
name: enzyme inhibitor
namespace: chebi_ontology
def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." []
subset: 3:STAR
subset: 3_STAR
synonym: "enzyme inhibitors" RELATED [ChEBI]
synonym: "enzyme inhibitors" RELATED [chebi]
synonym: "inhibidor enzimatico" RELATED [chebi]
synonym: "inhibidor enzimatico" RELATED [ChEBI]
synonym: "inhibidores enzimaticos" RELATED [ChEBI]
synonym: "inhibidores enzimaticos" RELATED [chebi]
synonym: "inhibiteur enzymatique" RELATED [chebi]
synonym: "inhibiteur enzymatique" RELATED [ChEBI]
synonym: "inhibiteurs enzymatiques" RELATED [ChEBI]
synonym: "inhibiteurs enzymatiques" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:23953
name: erythromycins
namespace: chebi_ontology
subset: 1:STAR
synonym: "erythromycins" RELATED [chebi]
is_a: CHEBI:25105 ! macrolide antibiotic
relationship: RO:0018038 CHEBI:23955 ! erythronolide

[Term]
id: CHEBI:23955
name: erythronolide
namespace: chebi_ontology
subset: 1:STAR
synonym: "erythronolides" RELATED [chebi]
is_a: CHEBI:25106 ! macrolide
relationship: RO:0000087 CHEBI:25212 ! has role metabolite

[Term]
id: CHEBI:23981
name: ethanolamines
namespace: chebi_ontology
subset: 3:STAR
synonym: "ethanolamine" RELATED [chebi]
is_a: CHEBI:22478 ! amino alcohol

[Term]
id: CHEBI:24061
name: fluorine atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "9F" RELATED [iupac]
synonym: "F" RELATED [iupac]
synonym: "Fluor" RELATED [chemidplus]
synonym: "fluor" RELATED [chebi]
synonym: "fluorine" RELATED [chebi]
synonym: "fluorum" RELATED [chebi]
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient

[Term]
id: CHEBI:24062
name: fluorine molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "fluorine compounds" RELATED [chebi]
synonym: "fluorine molecular entities" RELATED [chebi]
synonym: "fluorine molecular entity" RELATED [chebi]
is_a: CHEBI:24471 ! halogen molecular entity
relationship: BFO:0000051 CHEBI:24061 ! has part fluorine atom

[Term]
id: CHEBI:24068
name: fluoroamino acid
namespace: chebi_ontology
def: "An organofluorine compound that consists of an amino acid substituted by a fluoro group." []
subset: 3:STAR
synonym: "fluoroamino acids" RELATED [chebi]
is_a: CHEBI:24470 ! haloamino acid
is_a: CHEBI:37143 ! organofluorine compound

[Term]
id: CHEBI:24079
name: formamides
namespace: chebi_ontology
def: "Amides with the general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>NCHO (R<small><sup>1</small></sup> and R<small><sup>2</small></sup> can be H)." []
subset: 3:STAR
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:24127
name: fungicide
namespace: chebi_ontology
def: "A substance used to destroy fungal pests." []
subset: 3:STAR
synonym: "fungicides" RELATED [chebi]
is_a: CHEBI:25944 ! pesticide
is_a: CHEBI:35718 ! antifungal agent

[Term]
id: CHEBI:24129
name: furans
namespace: chebi_ontology
def: "Compounds containing at least one furan ring." []
subset: 3:STAR
synonym: "oxacyclopenta-2,4-dienes" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:24271
name: glucosamines
namespace: chebi_ontology
def: "Any  hexosamine that is glucose in which at least one of the hydroxy groups has been replaced by an amino group." []
subset: 3:STAR
is_a: CHEBI:24586 ! hexosamine

[Term]
id: CHEBI:24278
name: glucoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "glucosides" RELATED [chebi]
is_a: CHEBI:35313 ! hexoside

[Term]
id: CHEBI:24318
name: glutamine family amino acid
namespace: chebi_ontology
def: "An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." []
subset: 3:STAR
synonym: "glutamine family amino acids" RELATED [chebi]
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83813 ! proteinogenic amino acid

[Term]
id: CHEBI:24396
name: glycopeptide
namespace: chebi_ontology
alt_id: CHEBI:24395
alt_id: CHEBI:5478
def: "Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide." []
subset: 3:STAR
is_a: CHEBI:16670 ! peptide
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:24400
name: glycoside
namespace: chebi_ontology
def: "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO‒, RS‒, RSe‒, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms <em>N</em>-glycosides and <em>C</em>-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and <em>C</em>-glycosyl compounds, respectively." []
subset: 3:STAR
synonym: "glycosides" RELATED [chebi]
synonym: "O-glycoside" RELATED [chebi]
synonym: "O-glycosides" RELATED [chebi]
is_a: CHEBI:63161 ! glycosyl compound

[Term]
id: CHEBI:24431
name: chemical entity
namespace: chebi_ontology
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." []
subset: 3:STAR
subset: 3_STAR
synonym: "chemical entity" EXACT [UniProt]
synonym: "chemical entity" RELATED [uniprot_ft]
is_a: BFO:0000040 ! material entity

[Term]
id: CHEBI:24432
name: biological role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof within a biological context." []
subset: 3:STAR
subset: 3_STAR
synonym: "biological function" RELATED [ChEBI]
synonym: "biological function" RELATED [chebi]
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:24433
name: group
namespace: chebi_ontology
def: "A defined linked collection of atoms or a single atom within a molecular entity." []
subset: 3:STAR
subset: 3_STAR
synonym: "groupe" RELATED [iupac]
synonym: "groupe" RELATED [IUPAC]
synonym: "grupo" RELATED [iupac]
synonym: "grupo" RELATED [IUPAC]
synonym: "grupos" RELATED [IUPAC]
synonym: "grupos" RELATED [iupac]
synonym: "Gruppe" RELATED [chebi]
synonym: "Gruppe" RELATED [ChEBI]
synonym: "Rest" RELATED [chebi]
synonym: "Rest" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity
relationship: BFO:0000051 CHEBI:33250 ! has part atom

[Term]
id: CHEBI:24436
name: guanidines
namespace: chebi_ontology
def: "Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R<small><sup>1</small></sup>R<small><sup>2</small></sup>N)(R<small><sup>3</small></sup>R<small><sup>4</small></sup>N)C=N-R<small><sup>5</small></sup> and are related structurally to amidines and ureas." []
subset: 3:STAR
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:24470
name: haloamino acid
namespace: chebi_ontology
def: "Any non-proteinogenic amino acid carrying at least one halo group." []
subset: 3:STAR
synonym: "haloamino acids" RELATED [chebi]
is_a: CHEBI:83820 ! non-proteinogenic amino acid

[Term]
id: CHEBI:24471
name: halogen molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "halogen compounds" RELATED [chebi]
synonym: "halogen molecular entities" RELATED [chebi]
synonym: "halogen molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:24473 ! has part halogen

[Term]
id: CHEBI:24473
name: halogen
namespace: chebi_ontology
subset: 3:STAR
synonym: "group 17 elements" RELATED [chebi]
synonym: "group VII elements" RELATED [chebi]
synonym: "Halogene" RELATED [chebi]
synonym: "halogene" RELATED [chebi]
synonym: "halogenes" RELATED [chebi]
synonym: "halogeno" RELATED [chebi]
synonym: "halogenos" RELATED [chebi]
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:24531
name: heterocyclic antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "heterocyclic antibiotics" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:24532
name: organic heterocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic heterocycle" RELATED [ChEBI]
synonym: "organic heterocycle" RELATED [chebi]
synonym: "organic heterocyclic compounds" RELATED [chebi]
synonym: "organic heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33832 ! organic cyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:24533
name: heterodetic cyclic peptide
namespace: chebi_ontology
def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." []
subset: 3:STAR
synonym: "heterodetic cyclic peptides" RELATED [chebi]
synonym: "peptide cyclique heterodetique" RELATED [iupac]
synonym: "peptido ciclico heterodetico" RELATED [iupac]
is_a: CHEBI:23449 ! cyclic peptide

[Term]
id: CHEBI:24583
name: hexitol
namespace: chebi_ontology
subset: 3:STAR
synonym: "hexitol" RELATED [chebi]
synonym: "hexitols" RELATED [chebi]
is_a: CHEBI:17522 ! alditol

[Term]
id: CHEBI:24586
name: hexosamine
namespace: chebi_ontology
def: "Any 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group." []
subset: 3:STAR
synonym: "hexosamine" RELATED [chebi]
synonym: "hexosamines" RELATED [chebi]
is_a: CHEBI:60926 ! amino monosaccharide

[Term]
id: CHEBI:24613
name: homodetic cyclic peptide
namespace: chebi_ontology
def: "A homodetic cyclic peptide is a cyclic peptide in which the ring consists solely of amino-acid residues in peptide linkages." []
subset: 3:STAR
synonym: "homodetic cyclic peptides" RELATED [chebi]
synonym: "peptide cyclique homodetique" RELATED [iupac]
synonym: "peptido ciclico homodetico" RELATED [iupac]
is_a: CHEBI:23449 ! cyclic peptide

[Term]
id: CHEBI:24621
name: hormone
namespace: chebi_ontology
def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." []
subset: 3:STAR
synonym: "endocrine" RELATED [chebi]
synonym: "hormones" RELATED [chebi]
is_a: CHEBI:33280 ! molecular messenger
is_a: CHEBI:48705 ! agonist

[Term]
id: CHEBI:24628
name: imidazolidine-2,4-dione
namespace: chebi_ontology
def: "An imidazolidinone with oxo groups at position 2 and 4." []
subset: 3:STAR
is_a: CHEBI:55370 ! imidazolidinone

[Term]
id: CHEBI:24632
name: hydrocarbon
namespace: chebi_ontology
def: "A compound consisting of carbon and hydrogen only." []
subset: 3:STAR
synonym: "hidrocarburo" RELATED [iupac]
synonym: "hidrocarburos" RELATED [iupac]
synonym: "hydrocarbure" RELATED [iupac]
synonym: "Kohlenwasserstoff" RELATED [chebi]
synonym: "Kohlenwasserstoffe" RELATED [chebi]
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:24648
name: hydroxamic acid anion
namespace: chebi_ontology
def: "An oxoanion resulting from the removal of a proton from the hydroxy group of any hydroxamic acid." []
subset: 3:STAR
synonym: "hydroxamate" RELATED [chebi]
synonym: "hydroxamates" RELATED [chebi]
synonym: "hydroxamic acid anions" RELATED [chebi]
synonym: "hydroxamic anion" RELATED [chebi]
synonym: "hydroxamic anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
relationship: RO:0018033 CHEBI:24650 ! hydroxamic acid

[Term]
id: CHEBI:24650
name: hydroxamic acid
namespace: chebi_ontology
def: "A compound, R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>NHOH, derived from an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH) (<em>l</em> ≠ 0) by replacing ‒OH with ‒NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as <em>N</em>-hydroxy amides." []
subset: 3:STAR
synonym: "hydroxamic acids" RELATED [chebi]
synonym: "N-hydroxy amide" RELATED [chebi]
synonym: "N-hydroxy amides" RELATED [chebi]
synonym: "N-hydroxy-amide" RELATED [chebi]
synonym: "N-hydroxy-amides" RELATED [chebi]
synonym: "N-hydroxyamide" RELATED [chebi]
synonym: "N-hydroxyamides" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide
relationship: RO:0018034 CHEBI:24648 ! hydroxamic acid anion

[Term]
id: CHEBI:24651
name: hydroxides
namespace: chebi_ontology
def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: BFO:0000051 CHEBI:43176 ! has part hydroxy group

[Term]
id: CHEBI:24654
name: hydroxy fatty acid
namespace: chebi_ontology
def: "Any fatty acid carrying one or more hydroxy substituents." []
subset: 3:STAR
synonym: "hydroxy fatty acids" RELATED [lipidmaps]
is_a: CHEBI:35366 ! fatty acid
is_a: CHEBI:35868 ! hydroxy monocarboxylic acid
relationship: RO:0018034 CHEBI:59835 ! hydroxy fatty acid anion

[Term]
id: CHEBI:24669
name: hydroxy carboxylic acid
namespace: chebi_ontology
def: "Any carboxylic acid with at least one hydroxy group." []
subset: 3:STAR
synonym: "hydroxy carboxylic acids" RELATED [chebi]
synonym: "hydroxycarboxylic acid" RELATED [chebi]
synonym: "hydroxycarboxylic acids" RELATED [chebi]
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:24675
name: hydroxybenzoate
namespace: chebi_ontology
def: "Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent." []
subset: 3:STAR
synonym: "hydroxybenzoates" RELATED [chebi]
is_a: CHEBI:22718 ! benzoates
is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion
relationship: RO:0018033 CHEBI:24676 ! hydroxybenzoic acid

[Term]
id: CHEBI:24676
name: hydroxybenzoic acid
namespace: chebi_ontology
alt_id: CHEBI:50778
def: "Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring." []
subset: 3:STAR
synonym: "hydroxybenzoic acids" RELATED [chebi]
is_a: CHEBI:22723 ! benzoic acids
is_a: CHEBI:33853 ! phenols
relationship: RO:0018034 CHEBI:24675 ! hydroxybenzoate
relationship: RO:0018038 CHEBI:30746 ! benzoic acid

[Term]
id: CHEBI:2468
name: secondary alpha-hydroxy ketone
namespace: chebi_ontology
def: "An α-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary α-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups." []
subset: 3:STAR
synonym: "acyloin" RELATED [chebi]
synonym: "acyloins" RELATED [chebi]
synonym: "secondary alpha-hydroxy ketones" RELATED [chebi]
synonym: "secondary alpha-hydroxy-ketone" RELATED [chebi]
synonym: "secondary alpha-hydroxy-ketones" RELATED [chebi]
synonym: "secondary alpha-hydroxyketone" RELATED [chebi]
synonym: "secondary alpha-hydroxyketones" RELATED [chebi]
is_a: CHEBI:139588 ! alpha-hydroxy ketone
is_a: CHEBI:35681 ! secondary alcohol

[Term]
id: CHEBI:24712
name: hydroxymethyl group
namespace: chebi_ontology
subset: 3:STAR
synonym: "-CH2-OH" RELATED [iupac]
synonym: "serine side-chain" RELATED [chebi]
is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
relationship: RO:0018037 CHEBI:17790 ! methanol

[Term]
id: CHEBI:24753
name: hygromycin
namespace: chebi_ontology
subset: 3:STAR
synonym: "hygromycins" RELATED [chebi]
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic

[Term]
id: CHEBI:24780
name: imidazoles
namespace: chebi_ontology
def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." []
subset: 3:STAR
is_a: CHEBI:23677 ! diazole

[Term]
id: CHEBI:24782
name: imide
namespace: chebi_ontology
subset: 3:STAR
synonym: "imide" RELATED [chebi]
synonym: "imides" RELATED [chebi]
is_a: CHEBI:33257 ! secondary amide

[Term]
id: CHEBI:24797
name: indole phytoalexin
namespace: chebi_ontology
subset: 3:STAR
synonym: "indole phytoalexins" RELATED [chebi]
is_a: CHEBI:24828 ! indoles
relationship: RO:0000087 CHEBI:26115 ! has role phytoalexin

[Term]
id: CHEBI:24828
name: indoles
namespace: chebi_ontology
def: "Any compound containing an indole skeleton." []
subset: 3:STAR
is_a: CHEBI:22728 ! benzopyrrole

[Term]
id: CHEBI:24833
name: oxoacid
namespace: chebi_ontology
def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." []
subset: 3:STAR
subset: 3_STAR
synonym: "oxacids" RELATED [chebi]
synonym: "oxacids" RELATED [ChEBI]
synonym: "oxiacids" RELATED [chebi]
synonym: "oxiacids" RELATED [ChEBI]
synonym: "oxo acid" RELATED [chebi]
synonym: "oxo acid" RELATED [ChEBI]
synonym: "oxy-acids" RELATED [ChEBI]
synonym: "oxy-acids" RELATED [chebi]
synonym: "oxyacids" RELATED [chebi]
synonym: "oxyacids" RELATED [ChEBI]
is_a: CHEBI:24651 ! hydroxides
relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid

[Term]
id: CHEBI:24834
name: inorganic anion
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "inorganic anions" RELATED [ChEBI]
synonym: "inorganic anions" RELATED [chebi]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36914 ! inorganic ion

[Term]
id: CHEBI:24835
name: inorganic molecular entity
namespace: chebi_ontology
def: "A molecular entity that contains no carbon." []
subset: 3:STAR
subset: 3_STAR
synonym: "anorganische Verbindungen" RELATED [chebi]
synonym: "anorganische Verbindungen" RELATED [ChEBI]
synonym: "inorganic compounds" RELATED [ChEBI]
synonym: "inorganic compounds" RELATED [chebi]
synonym: "inorganic entity" RELATED [chebi]
synonym: "inorganic entity" RELATED [ChEBI]
synonym: "inorganic molecular entities" RELATED [chebi]
synonym: "inorganic molecular entities" RELATED [ChEBI]
synonym: "inorganics" RELATED [chebi]
synonym: "inorganics" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24836
name: inorganic oxide
namespace: chebi_ontology
subset: 3:STAR
synonym: "inorganic oxides" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25741 ! oxide

[Term]
id: CHEBI:24837
name: inorganic peroxide
namespace: chebi_ontology
def: "Compounds of structure ROOR' in which R and R' are inorganic groups." []
subset: 3:STAR
synonym: "inorganic peroxide" RELATED [chebi]
synonym: "inorganic peroxides" RELATED [chebi]
is_a: CHEBI:24836 ! inorganic oxide
is_a: CHEBI:25940 ! peroxides

[Term]
id: CHEBI:24839
name: inorganic salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "anorganisches Salz" RELATED [chebi]
synonym: "inorganic salts" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24866 ! salt

[Term]
id: CHEBI:24840
name: inorganic sulfate salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "inorganic sulfate salts" RELATED [chebi]
synonym: "inorganic sulfates" RELATED [chebi]
is_a: CHEBI:24839 ! inorganic salt
is_a: CHEBI:35175 ! sulfate salt

[Term]
id: CHEBI:24848
name: inositol
namespace: chebi_ontology
def: "Any cyclohexane-1,2,3,4,5,6-hexol." []
subset: 3:STAR
synonym: "1,2,3,4,5,6-cyclohexanehexol" RELATED [chebi]
synonym: "inositol" RELATED [iubmb]
synonym: "inositols" RELATED [chebi]
is_a: CHEBI:23451 ! cyclitol
is_a: CHEBI:37206 ! hexol

[Term]
id: CHEBI:24852
name: insecticide
namespace: chebi_ontology
def: "Strictly, a substance intended to kill members of the class <em>Insecta</em>.  In common usage, any substance used for preventing, destroying, repelling or controlling insects." []
subset: 3:STAR
synonym: "insecticides" RELATED [chebi]
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:24859
name: iodine atom
namespace: chebi_ontology
def: "Chemical element with atomic number 53." []
subset: 3:STAR
synonym: "53I" RELATED [iupac]
synonym: "I" RELATED [chebi]
synonym: "Iod" RELATED [chebi]
synonym: "iode" RELATED [chebi]
synonym: "iodine" RELATED [chebi]
synonym: "iodium" RELATED [chebi]
synonym: "J" RELATED [chebi]
synonym: "Jod" RELATED [chebi]
synonym: "yodo" RELATED [chebi]
is_a: CHEBI:24473 ! halogen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:24860
name: iodine molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "iodine compounds" RELATED [chebi]
synonym: "iodine molecular entities" RELATED [chebi]
synonym: "iodine molecular entity" RELATED [chebi]
is_a: CHEBI:24471 ! halogen molecular entity
relationship: BFO:0000051 CHEBI:24859 ! has part iodine atom

[Term]
id: CHEBI:24866
name: salt
namespace: chebi_ontology
def: "A salt is an assembly of cations and anions." []
subset: 3:STAR
synonym: "ionic compound" RELATED [chebi]
synonym: "ionic compounds" RELATED [chebi]
synonym: "sal" RELATED [chebi]
synonym: "sales" RELATED [chebi]
synonym: "salts" RELATED [chebi]
synonym: "Salz" RELATED [chebi]
synonym: "Salze" RELATED [chebi]
synonym: "sel" RELATED [chebi]
synonym: "sels" RELATED [chebi]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: BFO:0000051 CHEBI:22563 ! has part anion
relationship: BFO:0000051 CHEBI:36916 ! has part cation

[Term]
id: CHEBI:24867
name: monoatomic ion
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoatomic ions" RELATED [chebi]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:33238 ! monoatomic entity

[Term]
id: CHEBI:24868
name: organic salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic salts" RELATED [chebi]
synonym: "organisches Salz" RELATED [chebi]
is_a: CHEBI:24866 ! salt

[Term]
id: CHEBI:24869
name: ionophore
namespace: chebi_ontology
def: "A compound which can carry specific ions through membranes of cells or organelles." []
subset: 3:STAR
synonym: "ionophores" RELATED [chebi]
is_a: CHEBI:38632 ! membrane transport modulator

[Term]
id: CHEBI:24870
name: ion
namespace: chebi_ontology
def: "A molecular entity having a net electric charge." []
subset: 3:STAR
subset: 3_STAR
synonym: "Ion" EXACT [ChEBI]
synonym: "Ion" RELATED [chebi]
synonym: "ion" EXACT [ChEBI]
synonym: "ion" RELATED [chebi]
synonym: "Ionen" RELATED [chebi]
synonym: "Ionen" RELATED [ChEBI]
synonym: "iones" RELATED [ChEBI]
synonym: "iones" RELATED [chebi]
synonym: "ions" RELATED [ChEBI]
synonym: "ions" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24897
name: isoindoles
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:22728 ! benzopyrrole

[Term]
id: CHEBI:24913
name: isoprenoid
namespace: chebi_ontology
def: "Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives." []
subset: 3:STAR
synonym: "isoprenoid" RELATED [chebi]
synonym: "isoprenoids" RELATED [chebi]
is_a: CHEBI:18059 ! lipid

[Term]
id: CHEBI:24951
name: kanamycins
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic

[Term]
id: CHEBI:24995
name: lactam
namespace: chebi_ontology
def: "Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." []
subset: 3:STAR
synonym: "lactam" RELATED [iupac]
synonym: "lactams" RELATED [chebi]
synonym: "Laktam" RELATED [chebi]
synonym: "Laktame" RELATED [chebi]
is_a: CHEBI:23443 ! cyclic amide
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:25000
name: lactone
namespace: chebi_ontology
def: "Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." []
subset: 3:STAR
synonym: "Lacton" RELATED [chebi]
synonym: "lactona" RELATED [iupac]
synonym: "lactonas" RELATED [iupac]
synonym: "Lakton" RELATED [chebi]
synonym: "Laktone" RELATED [chebi]
is_a: CHEBI:33308 ! carboxylic ester
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:25022
name: leucomycin
namespace: chebi_ontology
subset: 1:STAR
synonym: "leucomycins" RELATED [chebi]
is_a: CHEBI:25106 ! macrolide
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:25061
name: lipopeptide antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "lipopeptide antibiotics" RELATED [chebi]
is_a: CHEBI:25903 ! peptide antibiotic
is_a: CHEBI:46895 ! lipopeptide

[Term]
id: CHEBI:25105
name: macrolide antibiotic
namespace: chebi_ontology
def: "A macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity." []
subset: 3:STAR
synonym: "macrolide antibiotics" RELATED [chebi]
synonym: "Makrolidantibiotika" RELATED [chebi]
is_a: CHEBI:25106 ! macrolide
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:25106
name: macrolide
namespace: chebi_ontology
def: "A macrocyclic lactone with a ring of twelve or more members derived from a polyketide." []
subset: 3:STAR
synonym: "macrolide" RELATED [chebi]
synonym: "macrolides" RELATED [chebi]
synonym: "Makrolid" RELATED [chebi]
is_a: CHEBI:26188 ! polyketide
is_a: CHEBI:63944 ! macrocyclic lactone

[Term]
id: CHEBI:25154
name: manganese molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "manganese compounds" RELATED [chebi]
synonym: "manganese molecular entities" RELATED [chebi]
synonym: "manganese molecular entity" RELATED [chebi]
is_a: CHEBI:33743 ! manganese group molecular entity
relationship: BFO:0000051 CHEBI:18291 ! has part manganese atom

[Term]
id: CHEBI:25189
name: 1,4-dimercaptobutane-2,3-diol
namespace: chebi_ontology
def: "A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group." []
subset: 3:STAR
synonym: "1,4-dimercapto-2,3-butanediol" RELATED [chemidplus]
synonym: "1,4-dimercaptobutane-2,3-diol" RELATED [chemidplus]
is_a: CHEBI:13643 ! glycol
is_a: CHEBI:22944 ! butanediols
is_a: CHEBI:29256 ! thiol

[Term]
id: CHEBI:25212
name: metabolite
namespace: chebi_ontology
alt_id: CHEBI:26619
alt_id: CHEBI:35220
def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." []
subset: 3:STAR
subset: 3_STAR
synonym: "metabolites" RELATED [chebi]
synonym: "metabolites" RELATED [ChEBI]
synonym: "primary metabolites" RELATED [chebi]
synonym: "primary metabolites" RELATED [ChEBI]
synonym: "secondary metabolites" RELATED [ChEBI]
synonym: "secondary metabolites" RELATED [chebi]
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:25213
name: metal cation
namespace: chebi_ontology
subset: 3:STAR
synonym: "a metal cation" RELATED [uniprot_ft]
synonym: "metal cations" RELATED [chebi]
is_a: CHEBI:23906 ! monoatomic cation
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:25248
name: methyl ester
namespace: chebi_ontology
def: "Any carboxylic ester resulting from the formal condensation of a carboxy group with methanol." []
subset: 3:STAR
synonym: "carboxylic acid methyl ester" RELATED [chebi]
synonym: "carboxylic acid methyl esters" RELATED [chebi]
is_a: CHEBI:33308 ! carboxylic ester
relationship: RO:0018038 CHEBI:17790 ! methanol

[Term]
id: CHEBI:25355
name: mitochondrial respiratory-chain inhibitor
namespace: chebi_ontology
subset: 3:STAR
synonym: "mitochondrial electron transport chain inhibitors" RELATED [chebi]
synonym: "mitochondrial electron-transport chain inhibitor" RELATED [chebi]
synonym: "mitochondrial respiratory chain inhibitors" RELATED [chebi]
is_a: CHEBI:38497 ! respiratory-chain inhibitor

[Term]
id: CHEBI:25367
name: molecule
namespace: chebi_ontology
def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "molecula" RELATED [iupac]
synonym: "molecula" RELATED [IUPAC]
synonym: "molecule" EXACT [IUPAC]
synonym: "molecule" RELATED [iupac]
synonym: "molecules" RELATED [IUPAC]
synonym: "molecules" RELATED [iupac]
synonym: "Molekuel" RELATED [chebi]
synonym: "Molekuel" RELATED [ChEBI]
synonym: "neutral molecular compounds" RELATED [iupac]
synonym: "neutral molecular compounds" RELATED [IUPAC]
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:25384
name: monocarboxylic acid
namespace: chebi_ontology
def: "An oxoacid containing a single carboxy group." []
subset: 3:STAR
synonym: "monocarboxylic acids" RELATED [chebi]
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:35757 ! monocarboxylic acid anion

[Term]
id: CHEBI:25388
name: monohydroxybenzoate
namespace: chebi_ontology
def: "A hydroxybenzoate carrying a single hydroxy substituent at unspecified position." []
subset: 3:STAR
synonym: "monohydroxybenzoates" RELATED [chebi]
is_a: CHEBI:24675 ! hydroxybenzoate
relationship: RO:0018033 CHEBI:25389 ! monohydroxybenzoic acid

[Term]
id: CHEBI:25389
name: monohydroxybenzoic acid
namespace: chebi_ontology
def: "Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring." []
subset: 3:STAR
synonym: "monohydroxybenzoic acids" RELATED [chebi]
is_a: CHEBI:24676 ! hydroxybenzoic acid
relationship: RO:0018034 CHEBI:25388 ! monohydroxybenzoate

[Term]
id: CHEBI:25414
name: monoatomic monocation
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoatomic monocations" RELATED [chebi]
synonym: "monovalent inorganic cations" RELATED [chebi]
is_a: CHEBI:23906 ! monoatomic cation

[Term]
id: CHEBI:25435
name: mutagen
namespace: chebi_ontology
def: "An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution." []
subset: 3:STAR
synonym: "mutagene" RELATED [chebi]
synonym: "mutagenes" RELATED [chebi]
synonym: "mutagenic agent" RELATED [chebi]
synonym: "mutageno" RELATED [chebi]
synonym: "mutagenos" RELATED [chebi]
synonym: "mutagens" RELATED [chebi]
is_a: CHEBI:50902 ! genotoxin

[Term]
id: CHEBI:25442
name: mycotoxin
namespace: chebi_ontology
def: "Poisonous substance produced by fungi." []
subset: 3:STAR
synonym: "fungal toxins" RELATED [chebi]
synonym: "mycotoxins" RELATED [chebi]
is_a: CHEBI:27026 ! toxin
is_a: CHEBI:76946 ! fungal metabolite

[Term]
id: CHEBI:25471
name: naphthalenemonosulfonate
namespace: chebi_ontology
subset: 1:STAR
synonym: "naphthalene monosulfonates" RELATED [chebi]
synonym: "naphthalenemonosulfonates" RELATED [chebi]
is_a: CHEBI:25478 ! naphthalenesulfonate

[Term]
id: CHEBI:25477
name: naphthalenes
namespace: chebi_ontology
def: "Any benzenoid aromatic compound having a skeleton composed of two <em>ortho</em>-fused benzene rings." []
subset: 3:STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound
is_a: CHEBI:36785 ! carbobicyclic compound

[Term]
id: CHEBI:25478
name: naphthalenesulfonate
namespace: chebi_ontology
subset: 1:STAR
synonym: "naphthalenesulfonates" RELATED [chebi]
is_a: CHEBI:22713 ! arenesulfonate oxoanion

[Term]
id: CHEBI:25481
name: naphthoquinone
namespace: chebi_ontology
def: "A polycyclic aromatic ketone metabolite of naphthalene." []
subset: 3:STAR
synonym: "naphthoquinones" RELATED [chebi]
is_a: CHEBI:36141 ! quinone

[Term]
id: CHEBI:25491
name: nematicide
namespace: chebi_ontology
def: "A substance used to destroy pests of the phylum <em>Nematoda</em> (roundworms)." []
subset: 3:STAR
synonym: "nematicides" RELATED [chebi]
synonym: "nematocide" RELATED [chebi]
synonym: "nematocides" RELATED [chebi]
is_a: CHEBI:25944 ! pesticide

[Term]
id: CHEBI:25512
name: neurotransmitter
namespace: chebi_ontology
def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." []
subset: 3:STAR
synonym: "neurotransmitters" RELATED [chebi]
is_a: CHEBI:33280 ! molecular messenger

[Term]
id: CHEBI:25529
name: pyridinecarboxamide
namespace: chebi_ontology
def: "A member of the class of pyridines that is a substituted pyridine in which at least one of the substituents is a carboxamide or <em>N</em>-substituted caraboxamide group." []
subset: 3:STAR
synonym: "pyridinecarboxamides" RELATED [chebi]
is_a: CHEBI:26421 ! pyridines
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:25555
name: nitrogen atom
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "7N" RELATED [IUPAC]
synonym: "7N" RELATED [iupac]
synonym: "azote" RELATED [IUPAC]
synonym: "azote" RELATED [iupac]
synonym: "N" RELATED [IUPAC]
synonym: "N" RELATED [iupac]
synonym: "nitrogen" RELATED [chebi]
synonym: "nitrogen" RELATED [ChEBI]
synonym: "nitrogeno" RELATED [chebi]
synonym: "nitrogeno" RELATED [ChEBI]
synonym: "Stickstoff" RELATED [chebi]
synonym: "Stickstoff" RELATED [ChEBI]
xref: WebElements:N
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient

[Term]
id: CHEBI:25558
name: organonitrogen heterocyclic antibiotic
namespace: chebi_ontology
subset: 3:STAR
synonym: "organonitrogen heterocyclic antibiotics" RELATED [chebi]
is_a: CHEBI:24531 ! heterocyclic antibiotic
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:25585
name: nonmetal atom
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "Nichtmetall" RELATED [chebi]
synonym: "Nichtmetall" RELATED [ChEBI]
synonym: "Nichtmetalle" RELATED [chebi]
synonym: "Nichtmetalle" RELATED [ChEBI]
synonym: "no metal" RELATED [chebi]
synonym: "no metal" RELATED [ChEBI]
synonym: "no metales" RELATED [ChEBI]
synonym: "no metales" RELATED [chebi]
synonym: "non-metal" RELATED [ChEBI]
synonym: "non-metal" RELATED [chebi]
synonym: "non-metaux" RELATED [ChEBI]
synonym: "non-metaux" RELATED [chebi]
synonym: "nonmetal" RELATED [ChEBI]
synonym: "nonmetal" RELATED [chebi]
synonym: "nonmetals" RELATED [chebi]
synonym: "nonmetals" RELATED [ChEBI]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:25605
name: nucleoside antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "nucleoside antibiotics" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:25608
name: nucleoside phosphate
namespace: chebi_ontology
def: "A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates." []
subset: 3:STAR
synonym: "NMP" RELATED [kegg.compound]
synonym: "nucleoside phosphates" RELATED [chebi]
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: RO:0018038 CHEBI:33838 ! nucleoside

[Term]
id: CHEBI:25675
name: oligomycin
namespace: chebi_ontology
def: "Any of the 26-membered ring macrolides produced by <em>Streptomyces</em> species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases." []
subset: 3:STAR
synonym: "oligomycins" RELATED [chebi]
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:72600 ! spiroketal
relationship: RO:0000087 CHEBI:20854 ! has role ATP synthase inhibitor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:25676
name: oligopeptide
namespace: chebi_ontology
alt_id: CHEBI:7755
def: "A peptide containing a relatively small number of amino acids." []
subset: 3:STAR
synonym: "Oligopeptid" RELATED [chebi]
synonym: "oligopeptido" RELATED [chebi]
is_a: CHEBI:16670 ! peptide

[Term]
id: CHEBI:25693
name: organic heteromonocyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic heteromonocyclic compounds" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33670 ! heteromonocyclic compound

[Term]
id: CHEBI:25696
name: organic anion
namespace: chebi_ontology
def: "Any organic ion with a net negative charge." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic anions" RELATED [ChEBI]
synonym: "organic anions" RELATED [chebi]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:25699 ! organic ion

[Term]
id: CHEBI:25697
name: organic cation
namespace: chebi_ontology
def: "Any organic ion with a net positive charge." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic cations" RELATED [chebi]
synonym: "organic cations" RELATED [ChEBI]
is_a: CHEBI:25699 ! organic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:25698
name: ether
namespace: chebi_ontology
def: "An organooxygen compound with formula ROR, where R is not hydrogen." []
subset: 3:STAR
synonym: "ethers" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:25699
name: organic ion
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "organic ions" RELATED [chebi]
synonym: "organic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:25703
name: organic phosphate
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic phosphate" RELATED [chebi]
synonym: "organic phosphate ester" RELATED [chebi]
synonym: "organic phosphate esters" RELATED [chebi]
synonym: "organic phosphates" RELATED [chebi]
synonym: "organophosphate ester" RELATED [chebi]
synonym: "organophosphate esters" RELATED [chebi]
is_a: CHEBI:25710 ! organophosphorus compound
is_a: CHEBI:26020 ! phosphate

[Term]
id: CHEBI:25704
name: organic sulfate
namespace: chebi_ontology
def: "Compounds of the general formula SO3HOR where R is an organyl group" []
subset: 3:STAR
synonym: "organic sulfates" RELATED [chebi]
is_a: CHEBI:26820 ! sulfates
relationship: RO:0018034 CHEBI:58958 ! organosulfate oxoanion

[Term]
id: CHEBI:2571
name: aliphatic alcohol
namespace: chebi_ontology
def: "An  alcohol derived from an aliphatic compound." []
subset: 3:STAR
synonym: "Aliphatic alcohol" RELATED [kegg.compound]
synonym: "aliphatic alcohols" RELATED [chebi]
synonym: "an aliphatic alcohol" RELATED [uniprot_ft]
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:25710
name: organophosphorus compound
namespace: chebi_ontology
def: "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." []
subset: 3:STAR
synonym: "organophosphorus compound" RELATED [chebi]
synonym: "organophosphorus compounds" RELATED [chebi]
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33285 ! heteroorganic entity

[Term]
id: CHEBI:25728
name: osmolyte
namespace: chebi_ontology
def: "A solute used by a cell under water stress to maintain cell volume." []
subset: 3:STAR
synonym: "osmolytes" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:25741
name: oxide
namespace: chebi_ontology
def: "An oxide is a chemical compound of oxygen with other chemical elements." []
subset: 3:STAR
subset: 3_STAR
synonym: "oxide" EXACT [ChEBI]
synonym: "oxide" RELATED [chebi]
synonym: "oxides" RELATED [ChEBI]
synonym: "oxides" RELATED [chebi]
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:25750
name: oxime
namespace: chebi_ontology
def: "Compounds of structure R<small><sub>2</sub></small>C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes." []
subset: 3:STAR
synonym: "oxime" RELATED [iupac]
synonym: "oximes" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: RO:0018034 CHEBI:142513 ! oxime anion

[Term]
id: CHEBI:25754
name: oxo carboxylic acid
namespace: chebi_ontology
def: "Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule." []
subset: 3:STAR
synonym: "oxo acids" RELATED [iupac]
synonym: "oxo carboxylic acids" RELATED [chebi]
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:35903 ! oxo carboxylic acid anion

[Term]
id: CHEBI:2580
name: unsaturated fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion containing at least one C-C unsaturated bond; formed by deprotonation of the carboxylic acid moiety." []
subset: 3:STAR
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:27208 ! unsaturated fatty acid

[Term]
id: CHEBI:25805
name: oxygen atom
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "8O" RELATED [IUPAC]
synonym: "8O" RELATED [iupac]
synonym: "O" RELATED [iupac]
synonym: "O" RELATED [IUPAC]
synonym: "oxigeno" RELATED [chebi]
synonym: "oxigeno" RELATED [ChEBI]
synonym: "oxygen" RELATED [ChEBI]
synonym: "oxygen" RELATED [chebi]
synonym: "oxygene" RELATED [chebi]
synonym: "oxygene" RELATED [ChEBI]
synonym: "Sauerstoff" RELATED [ChEBI]
synonym: "Sauerstoff" RELATED [chebi]
xref: KEGG:C00007
xref: WebElements:O
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient

[Term]
id: CHEBI:25806
name: oxygen molecular entity
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "oxygen molecular entities" RELATED [chebi]
synonym: "oxygen molecular entities" RELATED [ChEBI]
synonym: "oxygen molecular entity" EXACT [ChEBI]
synonym: "oxygen molecular entity" RELATED [chebi]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: BFO:0000051 CHEBI:25805 ! has part oxygen atom

[Term]
id: CHEBI:25807
name: organooxygen heterocyclic antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "organooxygen heterocyclic antibiotics" RELATED [chebi]
synonym: "oxygen containing heterocyclic antibiotics" RELATED [chebi]
is_a: CHEBI:24531 ! heterocyclic antibiotic

[Term]
id: CHEBI:25830
name: p-quinones
namespace: chebi_ontology
def: "A quinone in which the two oxo groups of the quinone are located <em>para</em> to each other on the 6-membered quinonoid ring." []
subset: 3:STAR
synonym: "p-quinone" RELATED [chebi]
synonym: "para-quinones" RELATED [chebi]
is_a: CHEBI:36141 ! quinone

[Term]
id: CHEBI:25865
name: penicillanic acids
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:35992 ! penams

[Term]
id: CHEBI:25900
name: aldopentose phosphate
namespace: chebi_ontology
subset: 3:STAR
synonym: "aldopentose phosphate" RELATED [chebi]
synonym: "aldopentose phosphates" RELATED [chebi]
is_a: CHEBI:35131 ! aldose phosphate
is_a: CHEBI:84055 ! pentose phosphate

[Term]
id: CHEBI:25901
name: pentose
namespace: chebi_ontology
def: "A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose)." []
subset: 3:STAR
synonym: "pentose" RELATED [chebi]
synonym: "pentoses" RELATED [chebi]
is_a: CHEBI:35381 ! monosaccharide

[Term]
id: CHEBI:25903
name: peptide antibiotic
namespace: chebi_ontology
def: "A chemically diverse class of peptides that exhibit antimicrobial properties." []
subset: 3:STAR
synonym: "peptide antibiotics" RELATED [chebi]
is_a: CHEBI:16670 ! peptide
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:25940
name: peroxides
namespace: chebi_ontology
def: "Compounds of structure ROOR'." []
subset: 3:STAR
synonym: "a peroxide" RELATED [uniprot_ft]
is_a: CHEBI:25741 ! oxide
relationship: BFO:0000051 CHEBI:29369 ! has part peroxy group
relationship: RO:0000087 CHEBI:63248 ! has role oxidising agent

[Term]
id: CHEBI:25944
name: pesticide
namespace: chebi_ontology
def: "Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests." []
subset: 3:STAR
synonym: "pesticides" RELATED [chebi]
synonym: "Pestizid" RELATED [chebi]
synonym: "Pestizide" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:26004
name: phenylpropanoid
namespace: chebi_ontology
def: "Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin." []
subset: 3:STAR
synonym: "phenylpropanoids" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:26020
name: phosphate
namespace: chebi_ontology
def: "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." []
subset: 3:STAR
synonym: "phosphates" RELATED [chebi]
is_a: CHEBI:26079 ! phosphoric acid derivative

[Term]
id: CHEBI:26045
name: phosphite ion
namespace: chebi_ontology
subset: 1:STAR
synonym: "phosphite ions" RELATED [chebi]
is_a: CHEBI:33461 ! phosphorus oxoanion

[Term]
id: CHEBI:26069
name: phosphonic acids
namespace: chebi_ontology
def: "HP(=O)(OH)<small><sub>2</sub></small>  (phosphonic acid) and its P-substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives

[Term]
id: CHEBI:26078
name: phosphoric acid
namespace: chebi_ontology
def: "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." []
subset: 3:STAR
synonym: "[PO(OH)3]" RELATED [iupac]
synonym: "acide phosphorique" RELATED [chebi]
synonym: "acidum phosphoricum" RELATED [chebi]
synonym: "H3PO4" RELATED [iupac]
synonym: "Orthophosphoric acid" RELATED [kegg.compound]
synonym: "orthophosphoric acid" RELATED [nist]
synonym: "Phosphate" RELATED [kegg.compound]
synonym: "Phosphoric acid" RELATED [kegg.compound]
synonym: "phosphoric acid" RELATED [iupac]
synonym: "Phosphorsaeure" RELATED [chebi]
synonym: "Phosphorsaeureloesungen" RELATED [chebi]
is_a: CHEBI:59698 ! phosphoric acids
relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer
relationship: RO:0000087 CHEBI:46787 ! has role solvent
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018034 CHEBI:39745 ! dihydrogenphosphate

[Term]
id: CHEBI:26079
name: phosphoric acid derivative
namespace: chebi_ontology
subset: 1:STAR
synonym: "phosphoric acid derivatives" RELATED [chebi]
synonym: "phosphoric acids" RELATED [chebi]
is_a: CHEBI:36359 ! phosphorus oxoacid derivative
relationship: RO:0018038 CHEBI:26078 ! phosphoric acid

[Term]
id: CHEBI:26082
name: phosphorus molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "phosphorus molecular entities" RELATED [chebi]
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: BFO:0000051 CHEBI:28659 ! has part phosphorus atom

[Term]
id: CHEBI:26094
name: benzenedicarboxylic acid
namespace: chebi_ontology
def: "A member of the class of benzoic acids in that consists of benzene substituted by two carboxy groups (A closed class)." []
subset: 3:STAR
is_a: CHEBI:22723 ! benzoic acids
is_a: CHEBI:35692 ! dicarboxylic acid

[Term]
id: CHEBI:26115
name: phytoalexin
namespace: chebi_ontology
def: "A toxin made by a plant that acts against an organism attacking it." []
subset: 3:STAR
synonym: "phytoalexins" RELATED [chebi]
is_a: CHEBI:38231 ! phytotoxin

[Term]
id: CHEBI:26130
name: biological pigment
namespace: chebi_ontology
def: "An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light." []
subset: 3:STAR
synonym: "pigments" RELATED [chebi]
is_a: CHEBI:52208 ! biophysical role

[Term]
id: CHEBI:26144
name: piperazines
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:26151
name: piperidines
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:26155
name: plant growth regulator
namespace: chebi_ontology
def: "A chemical, natural or artificial, that can affect the rate of growth of a plant." []
subset: 3:STAR
synonym: "plant growth regulators" RELATED [chebi]
is_a: CHEBI:39317 ! growth regulator

[Term]
id: CHEBI:26167
name: polar amino acid
namespace: chebi_ontology
alt_id: CHEBI:8283
def: "Any amino acid whose side chain is capable of forming one or more hydrogen bonds." []
subset: 3:STAR
synonym: "polar amino acid" RELATED [chebi]
synonym: "polar amino acids" RELATED [chebi]
synonym: "polar amino-acid" RELATED [chebi]
synonym: "polar amino-acids" RELATED [chebi]
is_a: CHEBI:33709 ! amino acid
relationship: RO:0018036 CHEBI:62031 ! polar amino acid zwitterion

[Term]
id: CHEBI:26177
name: polyene antibiotic
namespace: chebi_ontology
def: "A family of antibiotics containing a conjugated polyene moiety, usuallly isolated from some species of <em>Streptomyces</em>." []
subset: 3:STAR
synonym: "polyene antibiotics" RELATED [chebi]
is_a: CHEBI:33822 ! organic hydroxy compound
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:26188
name: polyketide
namespace: chebi_ontology
def: "Natural and synthetic compounds containing alternating carbonyl and methylene groups ('β-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides." []
subset: 3:STAR
synonym: "polyketide" RELATED [chebi]
synonym: "polyketides" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:26191
name: polyol
namespace: chebi_ontology
def: "A compound that contains two or more hydroxy groups." []
subset: 3:STAR
synonym: "polyols" RELATED [chebi]
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:26195
name: polyphenol
namespace: chebi_ontology
def: "Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group." []
subset: 3:STAR
synonym: "polyphenols" RELATED [chebi]
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:26199
name: polyprenol
namespace: chebi_ontology
alt_id: CHEBI:8317
def: "Any member of the class of  prenols possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of more than one isoprene units." []
subset: 3:STAR
synonym: "polyprenols" RELATED [chebi]
is_a: CHEBI:26244 ! prenols

[Term]
id: CHEBI:26208
name: polyunsaturated fatty acid
namespace: chebi_ontology
def: "Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome." []
subset: 3:STAR
synonym: "polyunsaturated fatty acids" RELATED [chebi]
synonym: "PUFA" RELATED [chebi]
synonym: "PUFAs" RELATED [chebi]
is_a: CHEBI:27208 ! unsaturated fatty acid
relationship: RO:0018034 CHEBI:76567 ! polyunsaturated fatty acid anion

[Term]
id: CHEBI:26216
name: potassium atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "19K" RELATED [iupac]
synonym: "K" RELATED [iupac]
synonym: "Kalium" RELATED [chemidplus]
synonym: "kalium" RELATED [iupac]
synonym: "potasio" RELATED [chebi]
synonym: "potassium" RELATED [chebi]
is_a: CHEBI:22314 ! alkali metal atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite

[Term]
id: CHEBI:26217
name: potassium molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "potassium molecular entities" RELATED [chebi]
synonym: "potassium molecular entity" RELATED [chebi]
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: BFO:0000051 CHEBI:26216 ! has part potassium atom

[Term]
id: CHEBI:26218
name: potassium salt
namespace: chebi_ontology
def: "Any alkali metal salt having potassium(1+) as the cation." []
subset: 3:STAR
synonym: "Kaliumsalz" RELATED [chebi]
synonym: "Kaliumsalze" RELATED [chebi]
synonym: "potassium salts" RELATED [chebi]
is_a: CHEBI:26217 ! potassium molecular entity
is_a: CHEBI:35479 ! alkali metal salt
relationship: BFO:0000051 CHEBI:29103 ! has part potassium(1+)

[Term]
id: CHEBI:26244
name: prenols
namespace: chebi_ontology
def: "Any alcohol possessing the general formula H-[CH<small><sub>2</sub></small>C(Me)=CHCH<small><sub>2</sub></small>]<small><sub><em>n</em></sub></small>OH in which the carbon skeleton is composed of one or more isoprene units (biogenetic precursors of the isoprenoids)." []
subset: 3:STAR
is_a: CHEBI:24913 ! isoprenoid
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:26271
name: proline
namespace: chebi_ontology
def: "An α-amino acid that is pyrrolidine bearing a carboxy substituent at position 2." []
subset: 3:STAR
synonym: "DL-Proline" RELATED [kegg.compound]
synonym: "Hpro" RELATED [iupac]
synonym: "Prolin" RELATED [chebi]
synonym: "prolina" RELATED [chebi]
synonym: "proline" RELATED [chebi]
synonym: "pyrrolidine-2-carboxylic acid" RELATED [iupac]
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:38260 ! pyrrolidines
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83056 ! has role Daphnia magna metabolite
relationship: RO:0018033 CHEBI:32872 ! prolinium
relationship: RO:0018034 CHEBI:32871 ! prolinate

[Term]
id: CHEBI:26273
name: proline derivative
namespace: chebi_ontology
def: "An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues." []
subset: 3:STAR
synonym: "proline derivatives" RELATED [chebi]
is_a: CHEBI:83821 ! amino-acid derivative
relationship: RO:0018038 CHEBI:26271 ! proline

[Term]
id: CHEBI:2634
name: amidine
namespace: chebi_ontology
def: "Derivatives of oxoacids R<small><sub><em>n</em></sub></small>E(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine." []
subset: 3:STAR
synonym: "amidine" RELATED [iupac]
synonym: "Amidines" RELATED [kegg.compound]
synonym: "amidines" RELATED [chebi]
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:2637
name: amikacin
namespace: chebi_ontology
def: "An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group." []
subset: 3:STAR
synonym: "1-N-(L(-)-gamma-amino-alpha-hydroxybutyryl)kanamycin A" RELATED [chemidplus]
synonym: "Amikacin" RELATED [kegg.compound]
synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine" RELATED [chemidplus]
is_a: CHEBI:22390 ! alpha-D-glucoside
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:47779 ! aminoglycoside
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50909 ! has role nephrotoxic agent
relationship: RO:0018033 CHEBI:84739 ! amikacin(4+)
relationship: RO:0018038 CHEBI:17630 ! kanamycin A

[Term]
id: CHEBI:26395
name: purine nucleotide
namespace: chebi_ontology
def: "Any nucleotide that has a purine nucleobase." []
subset: 3:STAR
synonym: "purine nucleotides" RELATED [chebi]
is_a: CHEBI:26401 ! purines
is_a: CHEBI:36976 ! nucleotide

[Term]
id: CHEBI:26400
name: purine ribonucleotide
namespace: chebi_ontology
def: "Any ribonucleotide that has a purine nucleobase." []
subset: 3:STAR
synonym: "purine ribonucleotides" RELATED [chebi]
is_a: CHEBI:26395 ! purine nucleotide
is_a: CHEBI:26561 ! ribonucleotide

[Term]
id: CHEBI:26401
name: purines
namespace: chebi_ontology
alt_id: CHEBI:13678
def: "A class of imidazopyrimidines that consists of purine and its substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:35875 ! imidazopyrimidine

[Term]
id: CHEBI:26416
name: pyridine alkaloid
namespace: chebi_ontology
subset: 3:STAR
synonym: "pyridine alkaloids" RELATED [chebi]
is_a: CHEBI:22315 ! alkaloid
is_a: CHEBI:26421 ! pyridines

[Term]
id: CHEBI:26420
name: pyridinemonocarboxylic acid
namespace: chebi_ontology
def: "A monocarboxylic acid in which the carboxy group is attached to a pyridine (or substituted pyridine) ring." []
subset: 3:STAR
synonym: "pyridinemonocarboxylic acids" RELATED [chebi]
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:26421 ! pyridines
is_a: CHEBI:33859 ! aromatic carboxylic acid
relationship: RO:0018034 CHEBI:38181 ! pyridinemonocarboxylate

[Term]
id: CHEBI:26421
name: pyridines
namespace: chebi_ontology
def: "Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives." []
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:26432
name: pyrimidine nucleobase
namespace: chebi_ontology
def: "A nucleobase whose skeleton is derived from pyrimidine." []
subset: 3:STAR
synonym: "a pyrimidine nucleobase" RELATED [uniprot_ft]
synonym: "pyrimidine bases" RELATED [chebi]
synonym: "pyrimidine nucleobase" RELATED [chebi]
synonym: "pyrimidine nucleobases" RELATED [chebi]
is_a: CHEBI:18282 ! nucleobase
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:26440
name: pyrimidine nucleoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-D-Ribosylpyrimidine" RELATED [kegg.compound]
synonym: "pyrimidine nucleosides" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:26455
name: pyrroles
namespace: chebi_ontology
def: "An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton." []
subset: 3:STAR
is_a: CHEBI:68452 ! azole

[Term]
id: CHEBI:26469
name: quaternary nitrogen compound
namespace: chebi_ontology
def: "A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen." []
subset: 3:STAR
is_a: CHEBI:35352 ! organonitrogen compound
relationship: BFO:0000051 CHEBI:35267 ! has part quaternary ammonium ion

[Term]
id: CHEBI:26509
name: quinoline alkaloid
namespace: chebi_ontology
subset: 3:STAR
synonym: "quinoline alkaloids" RELATED [chebi]
is_a: CHEBI:22315 ! alkaloid

[Term]
id: CHEBI:26512
name: quinolinemonocarboxylic acid
namespace: chebi_ontology
def: "Any aromatic carboxylic acid that contains a quinoline moiety that is substituted by one carboxy substituent." []
subset: 3:STAR
synonym: "quinolinemonocarboxylic acids" RELATED [chebi]
is_a: CHEBI:26513 ! quinolines
is_a: CHEBI:33859 ! aromatic carboxylic acid
relationship: RO:0018034 CHEBI:38773 ! quinolinemonocarboxylate

[Term]
id: CHEBI:26513
name: quinolines
namespace: chebi_ontology
def: "A class of aromatic heterocyclic compounds each of which contains a benzene ring <em>ortho</em> fused to carbons 2 and 3 of a pyridine ring." []
subset: 3:STAR
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:26523
name: reactive oxygen species
namespace: chebi_ontology
def: "Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." []
subset: 3:STAR
synonym: "ROS" RELATED [chebi]
is_a: CHEBI:25806 ! oxygen molecular entity

[Term]
id: CHEBI:26561
name: ribonucleotide
namespace: chebi_ontology
subset: 3:STAR
synonym: "ribonucleotides" RELATED [chebi]
is_a: CHEBI:26562 ! ribose phosphate
is_a: CHEBI:36976 ! nucleotide

[Term]
id: CHEBI:26562
name: ribose phosphate
namespace: chebi_ontology
subset: 3:STAR
synonym: "ribose phosphate" RELATED [chebi]
synonym: "ribose phosphates" RELATED [chebi]
is_a: CHEBI:25900 ! aldopentose phosphate

[Term]
id: CHEBI:26580
name: rifamycins
namespace: chebi_ontology
subset: 3:STAR
synonym: "rifamycin" RELATED [chebi]
is_a: CHEBI:22565 ! ansamycin
is_a: CHEBI:39270 ! naphthofuran

[Term]
id: CHEBI:26588
name: 1,3,5-triazines
namespace: chebi_ontology
def: "Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure." []
subset: 3:STAR
synonym: "s-triazines" RELATED [chebi]
is_a: CHEBI:38102 ! triazines

[Term]
id: CHEBI:26607
name: saturated fatty acid
namespace: chebi_ontology
def: "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." []
subset: 3:STAR
synonym: "saturated fatty acid" RELATED [chebi]
synonym: "saturated fatty acids" RELATED [chebi]
synonym: "SFA" RELATED [chebi]
synonym: "SFAs" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid

[Term]
id: CHEBI:26649
name: serine derivative
namespace: chebi_ontology
def: "An amino acid derivative resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of serine by a heteroatom. The definition normally excludes peptides containing serine residues." []
subset: 3:STAR
synonym: "serine derivatives" RELATED [chebi]
is_a: CHEBI:83821 ! amino-acid derivative
relationship: RO:0018038 CHEBI:17822 ! serine

[Term]
id: CHEBI:26658
name: sesquiterpenoid
namespace: chebi_ontology
def: "Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." []
subset: 3:STAR
synonym: "sesquiterpenoides" RELATED [chebi]
synonym: "sesquiterpenoids" RELATED [chebi]
is_a: CHEBI:26873 ! terpenoid
relationship: RO:0018040 CHEBI:35189 ! sesquiterpene

[Term]
id: CHEBI:26666
name: short-chain fatty acid
namespace: chebi_ontology
def: "An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid." []
subset: 3:STAR
synonym: "SCFA" RELATED [chebi]
synonym: "SCFAs" RELATED [chebi]
synonym: "short-chain fatty acids" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:58951 ! short-chain fatty acid anion

[Term]
id: CHEBI:26708
name: sodium atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "11Na" RELATED [iupac]
synonym: "Na" RELATED [iupac]
synonym: "Natrium" RELATED [chemidplus]
synonym: "natrium" RELATED [iupac]
synonym: "sodio" RELATED [chemidplus]
synonym: "sodium" RELATED [chebi]
is_a: CHEBI:22314 ! alkali metal atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite

[Term]
id: CHEBI:26710
name: sodium chloride
namespace: chebi_ontology
def: "An inorganic chloride salt having sodium(1+) as the counterion." []
subset: 3:STAR
synonym: "chlorure de sodium" RELATED [chebi]
synonym: "cloruro sodico" RELATED [chebi]
synonym: "common salt" RELATED [chemidplus]
synonym: "halite" RELATED [nist]
synonym: "Kochsalz" RELATED [chebi]
synonym: "NaCl" RELATED [iupac]
synonym: "natrii chloridum" RELATED [chebi]
synonym: "Natriumchlorid" RELATED [nist]
synonym: "rock salt" RELATED [chemidplus]
synonym: "salt" RELATED [chemidplus]
synonym: "sodium chloride" RELATED [chebi]
synonym: "table salt" RELATED [chemidplus]
is_a: CHEBI:36093 ! inorganic chloride
is_a: CHEBI:38702 ! inorganic sodium salt
relationship: RO:0000087 CHEBI:149552 ! has role emetic
relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound
relationship: RO:0000087 CHEBI:79314 ! has role flame retardant

[Term]
id: CHEBI:26712
name: sodium molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "sodium compounds" RELATED [chebi]
synonym: "sodium molecular entities" RELATED [chebi]
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: BFO:0000051 CHEBI:26708 ! has part sodium atom

[Term]
id: CHEBI:26714
name: sodium salt
namespace: chebi_ontology
def: "Any alkali metal salt having sodium(1+) as the cation." []
subset: 3:STAR
synonym: "Natriumsalz" RELATED [chebi]
synonym: "Natriumsalze" RELATED [chebi]
synonym: "sodium salts" RELATED [chebi]
is_a: CHEBI:26712 ! sodium molecular entity
is_a: CHEBI:35479 ! alkali metal salt
relationship: BFO:0000051 CHEBI:29101 ! has part sodium(1+)

[Term]
id: CHEBI:26739
name: sphingolipid
namespace: chebi_ontology
def: "Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone." []
subset: 3:STAR
synonym: "sphingolipids" RELATED [chebi]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:2676
name: amoxicillin
namespace: chebi_ontology
alt_id: CHEBI:133770
def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid" RELATED [chemidplus]
synonym: "alpha-amino-p-hydroxybenzylpenicillin" RELATED [chemidplus]
synonym: "Amoxicillin" RELATED [kegg.compound]
synonym: "Amoxicillin anhydrous" RELATED [kegg.compound]
synonym: "amoxycilin" RELATED [chebi]
synonym: "amoxycillin" RELATED [chemidplus]
synonym: "AX" RELATED [chebi]
synonym: "p-hydroxyampicillin" RELATED [chemidplus]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:51256 ! amoxicillin(1-)

[Term]
id: CHEBI:26761
name: steroid antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "steroid antibiotics" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:49319 ! carbocyclic antibiotic

[Term]
id: CHEBI:26775
name: stilbene
namespace: chebi_ontology
subset: 3:STAR
synonym: "1,1'-(1,2-ethenediyl)bis[benzene]" RELATED [nist]
synonym: "1,1'-(1,2-ethenediyl)bisbenzene" RELATED [chemidplus]
synonym: "1,1'-(1,2-ethenediyl)dibenzene" RELATED [chemidplus]
synonym: "1,1'-ethene-1,2-diyldibenzene" RELATED [chebi]
synonym: "1,2-diphenylethylene" RELATED [nist]
synonym: "alpha,beta-diphenylethylene" RELATED [nist]
synonym: "stilbene" RELATED [chemidplus]
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:26776
name: stilbenoid
namespace: chebi_ontology
def: "Any olefinic compound characterised by a 1,2-diphenylethylene backbone." []
subset: 3:STAR
synonym: "stilbenes" RELATED [chebi]
synonym: "stilbenoids" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:26788
name: streptomycins
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic

[Term]
id: CHEBI:26816
name: carbohydrate phosphate
namespace: chebi_ontology
subset: 3:STAR
synonym: "carbohydrate phosphates" RELATED [chebi]
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:26819
name: sulfuric ester
namespace: chebi_ontology
def: "An ester of an alcohol and sulfuric acid." []
subset: 3:STAR
synonym: "sulfate ester" RELATED [chebi]
synonym: "sulfuric acid ester" RELATED [chebi]
synonym: "sulfuric acid esters" RELATED [chebi]
is_a: CHEBI:35701 ! ester
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:2682
name: amphotericin B
namespace: chebi_ontology
alt_id: CHEBI:106303
alt_id: CHEBI:566395
def: "A macrolide antibiotic used to treat potentially life-threatening fungal infections." []
subset: 3:STAR
synonym: "AMPH-B" RELATED [drugbank]
synonym: "Amphotericine B" RELATED [drugbank]
synonym: "Liposomal Amphotericin B" RELATED [drugbank]
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:26177 ! polyene antibiotic
is_a: CHEBI:87113 ! antibiotic antifungal drug
relationship: RO:0000087 CHEBI:171664 ! has role antiamoebic agent
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:26820
name: sulfates
namespace: chebi_ontology
def: "Salts and esters of sulfuric acid" []
subset: 3:STAR
synonym: "sulfates" RELATED [chebi]
synonym: "sulfuric acid derivative" RELATED [chebi]
synonym: "sulphates" RELATED [chebi]
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:26822
name: sulfide
namespace: chebi_ontology
def: "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." []
subset: 3:STAR
synonym: "sulphides" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:26830
name: sulfonium compound
namespace: chebi_ontology
subset: 1:STAR
synonym: "sulfonium compounds" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:26833
name: sulfur atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "16S" RELATED [iupac]
synonym: "azufre" RELATED [chebi]
synonym: "Elemental sulfur" RELATED [kegg.compound]
synonym: "S" RELATED [iupac, kegg.compound]
synonym: "Schwefel" RELATED [chebi]
synonym: "soufre" RELATED [chebi]
synonym: "sulfur" RELATED [chebi, uniprot_ft]
synonym: "sulphur" RELATED [chebi]
synonym: "theion" RELATED [iupac]
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient

[Term]
id: CHEBI:26835
name: sulfur molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "sulfur molecular entities" RELATED [chebi]
synonym: "sulfur molecular entity" RELATED [chebi]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: BFO:0000051 CHEBI:26833 ! has part sulfur atom

[Term]
id: CHEBI:26836
name: sulfuric acid
namespace: chebi_ontology
def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." []
subset: 3:STAR
synonym: "[S(OH)2O2]" RELATED [molbase]
synonym: "[SO2(OH)2]" RELATED [iupac]
synonym: "Acide sulfurique" RELATED [chemidplus]
synonym: "Acido sulfurico" RELATED [chemidplus]
synonym: "Acidum sulfuricum" RELATED [chemidplus]
synonym: "H2SO4" RELATED [iupac]
synonym: "Schwefelsaeureloesungen" RELATED [chemidplus]
synonym: "Sulfuric acid" RELATED [kegg.compound]
synonym: "sulfuric acid" RELATED [chebi]
synonym: "sulphuric acid" RELATED [molbase]
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: RO:0000087 CHEBI:35223 ! has role catalyst
relationship: RO:0018034 CHEBI:45696 ! hydrogensulfate

[Term]
id: CHEBI:26873
name: terpenoid
namespace: chebi_ontology
def: "Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group." []
subset: 3:STAR
synonym: "Terpenoid" RELATED [chebi]
synonym: "terpenoide" RELATED [iupac]
synonym: "terpenoides" RELATED [iupac]
is_a: CHEBI:24913 ! isoprenoid
relationship: RO:0018040 CHEBI:35186 ! terpene

[Term]
id: CHEBI:26878
name: tertiary alcohol
namespace: chebi_ontology
def: "A tertiary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it." []
subset: 3:STAR
synonym: "tertiary alcohol" RELATED [chebi]
synonym: "tertiary alcohols" RELATED [chebi]
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:26888
name: tetrachlorobenzene
namespace: chebi_ontology
def: "Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions." []
subset: 3:STAR
synonym: "Tetrachlorbenzol" RELATED [chebi]
is_a: CHEBI:23132 ! chlorobenzenes

[Term]
id: CHEBI:26895
name: tetracyclines
namespace: chebi_ontology
def: "A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups." []
subset: 3:STAR
is_a: CHEBI:26188 ! polyketide
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0018040 CHEBI:32600 ! tetracene

[Term]
id: CHEBI:26912
name: oxolanes
namespace: chebi_ontology
def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." []
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:26959
name: thiocarboxylic ester
namespace: chebi_ontology
def: "An ester in which one or both oxygens of an ester group have been replaced by divalent sulfur." []
subset: 3:STAR
synonym: "thiocarboxylic esters" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:35701 ! ester

[Term]
id: CHEBI:26979
name: organic heterotricyclic compound
namespace: chebi_ontology
def: "An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms." []
subset: 3:STAR
synonym: "heterotricyclic compounds" RELATED [chebi]
synonym: "organic heterotricyclic compounds" RELATED [chebi]
is_a: CHEBI:36688 ! heterotricyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound
is_a: CHEBI:51959 ! organic tricyclic compound

[Term]
id: CHEBI:27026
name: toxin
namespace: chebi_ontology
def: "Poisonous substance produced by a biological organism such as a microbe, animal or plant." []
subset: 3:STAR
synonym: "toxins" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite
is_a: CHEBI:64909 ! poison

[Term]
id: CHEBI:27027
name: micronutrient
namespace: chebi_ontology
def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." []
subset: 3:STAR
synonym: "micronutrients" RELATED [chebi]
synonym: "trace elements" RELATED [chebi]
is_a: CHEBI:33284 ! nutrient

[Term]
id: CHEBI:27081
name: transition element atom
namespace: chebi_ontology
def: "An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell." []
subset: 3:STAR
synonym: "metal de transicion" RELATED [chebi]
synonym: "metal de transition" RELATED [chebi]
synonym: "metales de transicion" RELATED [chebi]
synonym: "metaux de transition" RELATED [chebi]
synonym: "transition element" RELATED [chebi]
synonym: "transition elements" RELATED [chebi]
synonym: "transition metal" RELATED [chebi]
synonym: "transition metals" RELATED [chebi]
synonym: "Uebergangselement" RELATED [chebi]
synonym: "Uebergangsmetalle" RELATED [chebi]
is_a: CHEBI:33521 ! metal atom

[Term]
id: CHEBI:27096
name: trichlorobenzene
namespace: chebi_ontology
def: "Any member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions." []
subset: 3:STAR
synonym: "Trichlorbenzol" RELATED [chebi]
is_a: CHEBI:23132 ! chlorobenzenes

[Term]
id: CHEBI:27136
name: triol
namespace: chebi_ontology
def: "A chemical compound containing three hydroxy groups." []
subset: 3:STAR
synonym: "triols" RELATED [chebi]
is_a: CHEBI:26191 ! polyol

[Term]
id: CHEBI:27171
name: organic heterobicyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "heterobicyclic compounds" RELATED [chebi]
synonym: "organic heterobicyclic compounds" RELATED [chebi]
is_a: CHEBI:33672 ! heterobicyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:27207
name: univalent carboacyl group
namespace: chebi_ontology
def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "univalent acyl group" RELATED [ChEBI]
synonym: "univalent acyl group" RELATED [chebi]
synonym: "univalent carboacyl groups" RELATED [ChEBI]
synonym: "univalent carboacyl groups" RELATED [chebi]
synonym: "univalent carboxylic acyl groups" RELATED [ChEBI]
synonym: "univalent carboxylic acyl groups" RELATED [chebi]
is_a: CHEBI:37838 ! carboacyl group

[Term]
id: CHEBI:27208
name: unsaturated fatty acid
namespace: chebi_ontology
def: "Any fatty acid containing at least one C=C or C≡C bond." []
subset: 3:STAR
synonym: "alkene acid" RELATED [chebi]
synonym: "olefinic acid" RELATED [chebi]
synonym: "unsaturated fatty acids" RELATED [chebi, lipidmaps]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:2580 ! unsaturated fatty acid anion

[Term]
id: CHEBI:27242
name: uridines
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:39446 ! pyrimidine ribonucleosides
relationship: RO:0018038 CHEBI:17568 ! uracil

[Term]
id: CHEBI:27283
name: very long-chain fatty acid
namespace: chebi_ontology
def: "A fatty acid which has a chain length greater than C<small><sub>22</sub></small>. Very long-chain fatty acids which have a chain length greater than C27 are also known as ultra-long-chain fatty acids." []
subset: 3:STAR
synonym: "higher fatty acid" RELATED [chebi]
synonym: "very long-chain fatty acids" RELATED [chebi]
synonym: "VLCFA" RELATED [chebi]
synonym: "VLCFAs" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:58950 ! very long-chain fatty acid anion

[Term]
id: CHEBI:27311
name: volatile oil component
namespace: chebi_ontology
def: "Any plant metabolite that is found naturally as a component of a volatile oil." []
subset: 3:STAR
synonym: "essential oil component" RELATED [chebi]
synonym: "essential oil components" RELATED [chebi]
synonym: "ethereal oil component" RELATED [chebi]
synonym: "ethereal oil components" RELATED [chebi]
synonym: "volatile oil components" RELATED [chebi]
is_a: CHEBI:76924 ! plant metabolite

[Term]
id: CHEBI:27314
name: water-soluble vitamin (role)
namespace: chebi_ontology
def: "Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine." []
subset: 3:STAR
synonym: "wasserloesliche Vitamine" RELATED [chebi]
synonym: "water-soluble vitamin" RELATED [chebi]
synonym: "water-soluble vitamins" RELATED [chebi]
is_a: CHEBI:33229 ! vitamin (role)

[Term]
id: CHEBI:27363
name: zinc atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "30Zn" RELATED [iupac]
synonym: "cinc" RELATED [chebi]
synonym: "zinc" RELATED [chebi]
synonym: "zincum" RELATED [chebi]
synonym: "Zink" RELATED [chebi]
synonym: "Zn" RELATED [iupac]
synonym: "Zn(II)" RELATED [kegg.compound]
synonym: "Zn2+" RELATED [kegg.compound]
is_a: CHEBI:33340 ! zinc group element atom
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient

[Term]
id: CHEBI:27364
name: zinc molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "zinc compounds" RELATED [chebi]
synonym: "zinc molecular entities" RELATED [chebi]
is_a: CHEBI:33673 ! zinc group molecular entity
relationship: BFO:0000051 CHEBI:27363 ! has part zinc atom

[Term]
id: CHEBI:27369
name: zwitterion
namespace: chebi_ontology
def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." []
subset: 3:STAR
subset: 3_STAR
synonym: "compose zwitterionique" RELATED [iupac]
synonym: "compose zwitterionique" RELATED [IUPAC]
synonym: "compuestos zwitterionicos" RELATED [IUPAC]
synonym: "compuestos zwitterionicos" RELATED [iupac]
synonym: "zwitteriones" RELATED [IUPAC]
synonym: "zwitteriones" RELATED [iupac]
synonym: "zwitterionic compounds" RELATED [IUPAC]
synonym: "zwitterionic compounds" RELATED [iupac]
is_a: CHEBI:51151 ! dipolar compound

[Term]
id: CHEBI:27405
name: streptidine
namespace: chebi_ontology
alt_id: CHEBI:26781
alt_id: CHEBI:9280
def: "An amino cyclitol that is <em>scyllo</em>-inositol in which the hydroxy groups at positions 1 and 3 are replaced by guanidino groups." []
subset: 3:STAR
synonym: "1,1'-(2,4,5,6-Tetrahydroxy-1,3-cyclohexylene)diguanidine" RELATED [chemidplus]
synonym: "1,3-diguanidino-2,4,5,6-cyclohexanetetrol" RELATED [chebi]
synonym: "N,N'-bis(aminoiminomethyl)streptamine" RELATED [chebi]
synonym: "N,N'-diamidinostreptamine" RELATED [chebi]
synonym: "Streptamine, N,N'-bis(aminoiminomethyl)-" RELATED [chemidplus]
synonym: "streptidin" RELATED [chemidplus]
synonym: "Streptidine" RELATED [kegg.compound]
is_a: CHEBI:24436 ! guanidines
is_a: CHEBI:61689 ! amino cyclitol
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0018033 CHEBI:184376 ! streptidine(2+)
relationship: RO:0018038 CHEBI:10642 ! scyllo-inositol

[Term]
id: CHEBI:27412
name: gentamycin C1
namespace: chebi_ontology
alt_id: CHEBI:24209
alt_id: CHEBI:5309
subset: 3:STAR
synonym: "Gentamicin C1" RELATED [kegg.compound]
synonym: "O-2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-alpha-D-ribo-heptopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-D-streptamine" RELATED [chemidplus]
is_a: CHEBI:28417 ! gentamycin C

[Term]
id: CHEBI:27561
name: oxirane
namespace: chebi_ontology
alt_id: CHEBI:24001
alt_id: CHEBI:4900
def: "A  saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom." []
subset: 3:STAR
synonym: "1,2-Epoxyaethan" RELATED [chemidplus]
synonym: "1,2-epoxyethane" RELATED [nist]
synonym: "Aethylenoxid" RELATED [chemidplus]
synonym: "Amprolene" RELATED [chemidplus]
synonym: "Anprolene" RELATED [nist]
synonym: "Anproline" RELATED [chemidplus]
synonym: "Dihydrooxirene" RELATED [chemidplus]
synonym: "Dimethylene oxide" RELATED [chemidplus]
synonym: "epoxyethane" RELATED [nist]
synonym: "ethene oxide" RELATED [nist]
synonym: "Ethylene oxide" RELATED [kegg.compound]
synonym: "ETO" RELATED [chemidplus]
synonym: "Oxacyclopropane" RELATED [chemidplus]
synonym: "Oxane" RELATED [chemidplus]
synonym: "Oxidoethane" RELATED [chemidplus]
synonym: "oxyde d'ethylene" RELATED [chemidplus]
synonym: "Oxyfume" RELATED [chebi]
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:36389 ! saturated organic heteromonocyclic parent
is_a: CHEBI:38104 ! oxacycle
relationship: RO:0000087 CHEBI:25435 ! has role mutagen
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite

[Term]
id: CHEBI:27565
name: 4-aminosalicylic acid
namespace: chebi_ontology
alt_id: CHEBI:1789
alt_id: CHEBI:20320
alt_id: CHEBI:41152
def: "An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4." []
subset: 3:STAR
synonym: "2-HYDROXY-4-AMINOBENZOIC ACID" RELATED [pdb-ccd]
synonym: "4-Aminosalicylate" RELATED [kegg.compound]
synonym: "4-Aminosalicylic acid" RELATED [kegg.compound]
synonym: "Aminosalicylic acid" RELATED [chemidplus]
synonym: "p-aminosalicylic acid" RELATED [nist]
synonym: "Para-amino salicylic acid" RELATED [chemidplus]
synonym: "PAS" RELATED [chemidplus]
is_a: CHEBI:22495 ! aminobenzoic acid
is_a: CHEBI:33853 ! phenols
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0018034 CHEBI:137598 ! 4-aminosalicylate(1-)
relationship: RO:0018038 CHEBI:16914 ! salicylic acid

[Term]
id: CHEBI:27594
name: carbon atom
namespace: chebi_ontology
alt_id: CHEBI:23009
alt_id: CHEBI:3399
subset: 3:STAR
subset: 3_STAR
synonym: "6C" RELATED [IUPAC]
synonym: "6C" RELATED [iupac]
synonym: "C" RELATED [IUPAC, KEGG_COMPOUND]
synonym: "C" RELATED [iupac, kegg.compound]
synonym: "Carbon" EXACT [KEGG_COMPOUND]
synonym: "Carbon" RELATED [kegg.compound]
synonym: "Carbon" RELATED [KEGG_COMPOUND]
synonym: "carbon" RELATED [ChEBI]
synonym: "carbon" RELATED [chebi]
synonym: "carbone" RELATED [ChEBI]
synonym: "carbone" RELATED [chebi]
synonym: "carbonium" RELATED [chebi]
synonym: "carbonium" RELATED [ChEBI]
synonym: "carbono" RELATED [ChEBI]
synonym: "carbono" RELATED [chebi]
synonym: "Kohlenstoff" RELATED [ChEBI]
synonym: "Kohlenstoff" RELATED [chebi]
xref: KEGG:C06265
xref: WebElements:C
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33306 ! carbon group element atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient

[Term]
id: CHEBI:2762
name: antimycin A
namespace: chebi_ontology
alt_id: CHEBI:22584
alt_id: CHEBI:40908
def: "A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by <em>Streptomyces</em> bacteria and has found commercial use as a fish poison." []
subset: 3:STAR
synonym: "Antimycin A1" RELATED [kegg.compound]
synonym: "antimycin A1b" RELATED [chebi]
synonym: "Antipiricullin" RELATED [chemidplus]
synonym: "Fintrol" RELATED [chemidplus]
synonym: "Virosin" RELATED [chemidplus]
is_a: CHEBI:145556 ! macrodiolide
is_a: CHEBI:22702 ! benzamides
is_a: CHEBI:24079 ! formamides
is_a: CHEBI:33853 ! phenols
relationship: RO:0000087 CHEBI:167183 ! has role piscicide
relationship: RO:0000087 CHEBI:25355 ! has role mitochondrial respiratory-chain inhibitor
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:27641
name: cycloheximide
namespace: chebi_ontology
alt_id: CHEBI:23484
alt_id: CHEBI:4015
def: "A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon  bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium <em>Streptomyces griseus</em>." []
subset: 3:STAR
synonym: "3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide" RELATED [chemidplus]
synonym: "Cycloheximid" RELATED [chebi]
synonym: "Cycloheximide" RELATED [kegg.compound]
synonym: "cycloheximide" RELATED [uniprot_ft]
synonym: "naramycin" RELATED [chemidplus]
synonym: "naramycin A" RELATED [chemidplus]
synonym: "Zykloheximid" RELATED [chebi]
is_a: CHEBI:35356 ! dicarboximide
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:48589 ! piperidones
is_a: CHEBI:49318 ! piperidine antibiotic
is_a: CHEBI:87114 ! antibiotic fungicide
relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent
relationship: RO:0000087 CHEBI:173084 ! has role ferroptosis inhibitor
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018038 CHEBI:5435 ! piperidine-2,6-dione

[Term]
id: CHEBI:27644
name: chlortetracycline
namespace: chebi_ontology
alt_id: CHEBI:23164
alt_id: CHEBI:3653
def: "A member of the class of tetracyclines with formula C<small><sub>22</sub></small>H<small><sub>23</sub></small>ClN<small><sub>2</sub></small>O<small><sub>8</sub></small> isolated from <em>Streptomyces aureofaciens</em>." []
subset: 3:STAR
synonym: "7-Chlorotetracycline" RELATED [kegg.compound]
is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone
is_a: CHEBI:26895 ! tetracyclines
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:50996 ! tertiary amino compound
is_a: CHEBI:83403 ! monochlorobenzenes
relationship: RO:0000087 CHEBI:22986 ! has role calcium ionophore
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:39442 ! has role fluorescent probe
relationship: RO:0018034 CHEBI:133598 ! chlortetracycline(1-)

[Term]
id: CHEBI:27656
name: camptothecin
namespace: chebi_ontology
alt_id: CHEBI:22997
alt_id: CHEBI:3343
def: "A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-<em>b</em>]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the <i>S</i> enantiomer)." []
subset: 3:STAR
synonym: "(+)-camptothecin" RELATED [drugbank]
synonym: "(+)-camptothecine" RELATED [drugbank]
synonym: "(S)-(+)-camptothecin" RELATED [drugbank]
synonym: "20(S)-camptothecine" RELATED [chemidplus]
synonym: "21,22-Secocamptothecin-21-oic acid lactone" RELATED [chemidplus]
synonym: "Camptothecin" RELATED [kegg.compound]
synonym: "Camptothecine" RELATED [chemidplus]
synonym: "CPT" RELATED [drugbank]
synonym: "D-camptothecin" RELATED [drugbank]
is_a: CHEBI:18946 ! delta-lactone
is_a: CHEBI:26509 ! quinoline alkaloid
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:48626 ! pyranoindolizinoquinoline
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:50276 ! has role EC 5.99.1.2 (DNA topoisomerase) inhibitor
relationship: RO:0000087 CHEBI:50902 ! has role genotoxin
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite

[Term]
id: CHEBI:27666
name: actinomycin D
namespace: chebi_ontology
alt_id: CHEBI:22218
alt_id: CHEBI:2446
subset: 3:STAR
synonym: "2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide" RELATED [chemidplus]
synonym: "ActD" RELATED [chebi]
synonym: "actinomycin C1" RELATED [chebi]
synonym: "Actinomycin D" RELATED [kegg.compound]
synonym: "actinomycin IV" RELATED [chemidplus]
synonym: "Dactinomycin" RELATED [kegg.compound]
is_a: CHEBI:15369 ! actinomycin
relationship: RO:0000087 CHEBI:25435 ! has role mutagen

[Term]
id: CHEBI:27701
name: oxytetracycline
namespace: chebi_ontology
alt_id: CHEBI:25811
alt_id: CHEBI:521157
alt_id: CHEBI:596903
alt_id: CHEBI:7871
def: "A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including <em>Mycoplasma pneumoniae</em>, <em>Pasteurella pestis</em>, <em>Escherichia coli</em>, <em>Haemophilus influenzae</em> (respiratory infections), and <em>Diplococcus pneumoniae</em>." []
subset: 3:STAR
synonym: "5-Hydroxytetracycline" RELATED [chemidplus]
synonym: "Oxyterracin" RELATED [chemidplus]
synonym: "Oxyterracine" RELATED [chemidplus]
synonym: "Oxytetracyclin" RELATED [chemidplus]
synonym: "Oxytetracycline (anhydrous)" RELATED [chemidplus]
synonym: "Oxytetracycline amphoteric" RELATED [chemidplus]
is_a: CHEBI:26895 ! tetracyclines
relationship: RO:0000087 CHEBI:35472 ! has role anti-inflammatory drug
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018036 CHEBI:133011 ! oxytetracycline zwitterion

[Term]
id: CHEBI:27780
name: detergent
namespace: chebi_ontology
alt_id: CHEBI:23648
alt_id: CHEBI:4456
def: "A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions." []
subset: 3:STAR
synonym: "Detergents" RELATED [kegg.compound]
is_a: CHEBI:33232 ! application
is_a: CHEBI:35195 ! surfactant

[Term]
id: CHEBI:27822
name: 2-aminobenzimidazole
namespace: chebi_ontology
alt_id: CHEBI:1016
alt_id: CHEBI:19467
def: "A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group." []
subset: 3:STAR
synonym: "2-Aminobenzimidazole" RELATED [kegg.compound]
synonym: "2-aminobenzimidazole" RELATED [uniprot_ft]
synonym: "2-Iminobenzimidazoline" RELATED [chemidplus]
synonym: "Benzimidazol-2-ylamine" RELATED [chemidplus]
is_a: CHEBI:22715 ! benzimidazoles
relationship: RO:0000087 CHEBI:83399 ! has role marine xenobiotic metabolite

[Term]
id: CHEBI:27881
name: resveratrol
namespace: chebi_ontology
alt_id: CHEBI:11685
alt_id: CHEBI:1366
alt_id: CHEBI:19867
def: "A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups." []
subset: 3:STAR
synonym: "3,4',5-Trihydroxystilbene" RELATED [kegg.compound]
synonym: "Resveratrol" RELATED [kegg.compound]
is_a: CHEBI:26195 ! polyphenol
is_a: CHEBI:33572 ! resorcinols
is_a: CHEBI:36027 ! stilbenol
relationship: RO:0000087 CHEBI:140922 ! has role glioma-associated oncogene inhibitor
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:22586 ! has role antioxidant
relationship: RO:0000087 CHEBI:26115 ! has role phytoalexin

[Term]
id: CHEBI:27902
name: tetracycline
namespace: chebi_ontology
alt_id: CHEBI:26894
alt_id: CHEBI:45729
alt_id: CHEBI:9474
def: "A broad-spectrum polyketide antibiotic produced by the <em>Streptomyces genus</em> of actinobacteria." []
subset: 3:STAR
synonym: "(4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide" RELATED [chemidplus]
synonym: "Abramycin" RELATED [chemidplus]
synonym: "Anhydrotetracycline" RELATED [drugbank]
synonym: "Deschlorobiomycin" RELATED [chemidplus]
synonym: "Liquamycin" RELATED [chemidplus]
synonym: "Tetracyclin" RELATED [chebi]
synonym: "TETRACYCLINE" RELATED [pdb-ccd]
synonym: "Tetracycline" RELATED [kegg.compound]
synonym: "tetracycline" RELATED [chebi]
synonym: "Tetrazyklin" RELATED [chebi]
synonym: "Tsiklomitsin" RELATED [chemidplus]
is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone
is_a: CHEBI:26895 ! tetracyclines
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018036 CHEBI:77932 ! tetracycline zwitterion

[Term]
id: CHEBI:27933
name: beta-lactam antibiotic
namespace: chebi_ontology
alt_id: CHEBI:10427
alt_id: CHEBI:22844
def: "An organonitrogen heterocyclic antibiotic that contains a β-lactam ring." []
subset: 3:STAR
synonym: "beta-Lactam antibiotics" RELATED [kegg.compound]
synonym: "beta-lactam antibiotics" RELATED [chebi]
is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic
is_a: CHEBI:35627 ! beta-lactam

[Term]
id: CHEBI:27955
name: streptamine
namespace: chebi_ontology
alt_id: CHEBI:26779
alt_id: CHEBI:9277
def: "An amino cyclitol consisting of <em>scyllo</em>-inositol with the hydroxy groups at positions 1 and 3 replaced by unsubstituted amino groups." []
subset: 3:STAR
synonym: "Streptamine" RELATED [kegg.compound]
is_a: CHEBI:61689 ! amino cyclitol
relationship: RO:0018038 CHEBI:10642 ! scyllo-inositol

[Term]
id: CHEBI:28001
name: vancomycin
namespace: chebi_ontology
alt_id: CHEBI:27276
alt_id: CHEBI:49941
alt_id: CHEBI:9931
def: "A complex glycopeptide from <em>Streptomyces orientalis</em>. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria <em>Staphylococcus aureus</em> and <em>Clostridium difficile</em>." []
subset: 3:STAR
synonym: "(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid" RELATED [chebi]
synonym: "(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):C(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]" RELATED [jcbn]
synonym: "vancomicin" RELATED [chebi]
synonym: "VANCOMYCIN" RELATED [pdb-ccd]
synonym: "Vancomycin" RELATED [kegg.compound]
is_a: CHEBI:24396 ! glycopeptide
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018033 CHEBI:76842 ! vancomycin(1+)
relationship: RO:0018038 CHEBI:47724 ! vancomycin aglycone

[Term]
id: CHEBI:28077
name: rifampicin
namespace: chebi_ontology
alt_id: CHEBI:26577
alt_id: CHEBI:45308
alt_id: CHEBI:8858
def: "A member of the class of rifamycins that is a a semisynthetic antibiotic derived from <em>Amycolatopsis rifamycinica</em> (previously known as <em>Amycolatopsis mediterranei</em> and <em>Streptomyces mediterranei</em>)." []
subset: 3:STAR
synonym: "3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV" RELATED [chemidplus]
synonym: "RFP" RELATED [drugbank]
synonym: "rifamcin" RELATED [chebi]
synonym: "Rifampicin" RELATED [kegg.compound]
synonym: "Rifampin" RELATED [kegg.compound]
is_a: CHEBI:26580 ! rifamycins
is_a: CHEBI:38532 ! hydrazone
is_a: CHEBI:46847 ! N-iminopiperazine
is_a: CHEBI:46920 ! N-methylpiperazine
is_a: CHEBI:59779 ! cyclic ketal
is_a: CHEBI:72588 ! semisynthetic derivative
relationship: RO:0000087 CHEBI:171664 ! has role antiamoebic agent
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug
relationship: RO:0000087 CHEBI:37416 ! has role EC 2.7.7.6 (RNA polymerase) inhibitor
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:48422 ! has role angiogenesis inhibitor
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0000087 CHEBI:63726 ! has role neuroprotective agent
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77318 ! has role pregnane X receptor agonist
relationship: RO:0018036 CHEBI:71365 ! rifampicin zwitterion

[Term]
id: CHEBI:28079
name: beta-L-arabinoside
namespace: chebi_ontology
alt_id: CHEBI:10422
alt_id: CHEBI:22818
subset: 3:STAR
synonym: "beta-L-Arabinoside" RELATED [kegg.compound]
synonym: "beta-L-arabinosides" RELATED [chebi]
is_a: CHEBI:22601 ! arabinoside

[Term]
id: CHEBI:28084
name: 3-(carbamoyloxymethyl)cephalosporin
namespace: chebi_ontology
alt_id: CHEBI:1462
alt_id: CHEBI:19970
subset: 3:STAR
synonym: "3-(carbamoyloxymethyl)cephalosporins" RELATED [chebi]
synonym: "3-Carbamoyloxymethylcephem" RELATED [kegg.compound]
is_a: CHEBI:23066 ! cephalosporin

[Term]
id: CHEBI:28098
name: kanamycin B
namespace: chebi_ontology
alt_id: CHEBI:14489
alt_id: CHEBI:24948
alt_id: CHEBI:24949
alt_id: CHEBI:6107
subset: 3:STAR
synonym: "2'-amino-2'-deoxykanamycin" RELATED [chemidplus]
synonym: "Bekanamycin" RELATED [kegg.compound]
synonym: "Kanamycin B" RELATED [kegg.compound]
synonym: "Nebramycin factor 5" RELATED [kegg.compound]
synonym: "Nebramycin V" RELATED [chemidplus]
synonym: "O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->6))-2-deoxy-D-streptamine" RELATED [chemidplus]
is_a: CHEBI:24951 ! kanamycins
relationship: RO:0018033 CHEBI:58549 ! kanamycin B(5+)

[Term]
id: CHEBI:28201
name: rotenone
namespace: chebi_ontology
alt_id: CHEBI:26583
alt_id: CHEBI:8897
def: "A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-<em>b</em>]furo[2,3-<em>h</em>]chromen-6(6a<em>H</em>)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2<i>R</i>,6a<i>S</i>,12a<i>S</i>-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of <em>Derris elliptica</em>)." []
subset: 3:STAR
synonym: "(-)-cis-rotenone" RELATED [chemidplus]
synonym: "(-)-rotenone" RELATED [chemidplus]
synonym: "(12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one" RELATED [chebi]
synonym: "5'beta-rotenone" RELATED [nist]
synonym: "[2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one" RELATED [nist]
synonym: "barbasco" RELATED [chemidplus]
synonym: "canex" RELATED [chemidplus]
synonym: "dactinol" RELATED [chemidplus]
synonym: "Derris" RELATED [chebi]
synonym: "noxfire" RELATED [chemidplus]
synonym: "paraderil" RELATED [chemidplus]
synonym: "Rotenone" RELATED [kegg.compound]
synonym: "tubatoxin" RELATED [chemidplus]
is_a: CHEBI:38164 ! organic heteropentacyclic compound
is_a: CHEBI:72581 ! rotenones
relationship: RO:0000087 CHEBI:167183 ! has role piscicide
relationship: RO:0000087 CHEBI:22917 ! has role phytogenic insecticide
relationship: RO:0000087 CHEBI:27026 ! has role toxin
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:38498 ! has role mitochondrial NADH:ubiquinone reductase inhibitor

[Term]
id: CHEBI:28240
name: dichloroacetate
namespace: chebi_ontology
alt_id: CHEBI:23694
def: "A monocarboxylic acid anion that is the conjugate base of dichloroacetic acid." []
subset: 3:STAR
synonym: "dichloracetate" RELATED [chemidplus]
synonym: "dichloroacetate ion" RELATED [chemidplus]
synonym: "dichloroacetic acid ion(1-)" RELATED [chemidplus]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0018033 CHEBI:36386 ! dichloroacetic acid
relationship: RO:0018038 CHEBI:30089 ! acetate

[Term]
id: CHEBI:28306
name: semicarbazide
namespace: chebi_ontology
alt_id: CHEBI:26644
alt_id: CHEBI:9102
def: "A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine." []
subset: 3:STAR
synonym: "Aminoharnstoff" RELATED [chebi]
synonym: "Aminourea" RELATED [kegg.compound]
synonym: "Carbamidsaeurehydrazid" RELATED [chebi]
synonym: "Carbamoylhydrazine" RELATED [kegg.compound]
synonym: "carbamylhydrazine" RELATED [chemidplus]
synonym: "carbazamide" RELATED [chemidplus]
synonym: "Hydrazinecarboxamide" EXACT [KEGG_COMPOUND]
synonym: "Hydrazinecarboxamide" RELATED [kegg.compound]
synonym: "Semicarbazide" RELATED [kegg.compound]
synonym: "Semikarbazid" RELATED [nist]
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:35363 ! carbohydrazide
is_a: CHEBI:47857 ! ureas
is_a: CHEBI:64708 ! one-carbon compound

[Term]
id: CHEBI:28368
name: novobiocin
namespace: chebi_ontology
alt_id: CHEBI:25597
alt_id: CHEBI:44505
alt_id: CHEBI:7644
def: "A coumarin-derived antibiotic obtained from <em>Streptomyces niveus</em>." []
subset: 3:STAR
synonym: "N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide" RELATED [chebi]
synonym: "Novobiocin" RELATED [kegg.compound]
is_a: CHEBI:23003 ! carbamate ester
is_a: CHEBI:25698 ! ether
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:35313 ! hexoside
is_a: CHEBI:37912 ! hydroxycoumarin
is_a: CHEBI:63367 ! monosaccharide derivative
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
relationship: RO:0000087 CHEBI:62868 ! has role hepatoprotective agent
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:71339 ! novobiocin(1-)

[Term]
id: CHEBI:28417
name: gentamycin C
namespace: chebi_ontology
alt_id: CHEBI:14294
alt_id: CHEBI:24208
alt_id: CHEBI:5308
subset: 3:STAR
synonym: "Gentamicin C" RELATED [kegg.compound]
is_a: CHEBI:17833 ! gentamycin
relationship: RO:0018033 CHEBI:75616 ! gentamicin C(5+)

[Term]
id: CHEBI:28545
name: valinomycin
namespace: chebi_ontology
alt_id: CHEBI:27269
alt_id: CHEBI:66347
alt_id: CHEBI:9924
def: "A twelve-membered cyclodepsipeptide composed of three repeating <small>D</small>-α-hydroxyisovaleryl-<small>D</small>-valyl-<small>L</small>-lactoyl-<small>L</small>-valyl units joined in sequence. An antibiotic found in several <em>Streptomyces</em> strains." []
subset: 3:STAR
synonym: "Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)" RELATED [chemidplus]
synonym: "cyclo[-D-O-Val-D-Val-L-O-Ala-L-Val]3" RELATED [chebi]
synonym: "Valinomycin" RELATED [kegg.compound]
is_a: CHEBI:35213 ! cyclodepsipeptide
is_a: CHEBI:51026 ! macrocycle
relationship: RO:0000087 CHEBI:22587 ! has role antiviral agent
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0000087 CHEBI:88227 ! has role potassium ionophore

[Term]
id: CHEBI:28600
name: farnesol
namespace: chebi_ontology
alt_id: CHEBI:24013
alt_id: CHEBI:24014
alt_id: CHEBI:4978
def: "A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1." []
subset: 3:STAR
synonym: "3,7,11-trimethyl-2,6,10-dodecatrien-1-ol" RELATED [chemidplus]
synonym: "3,7,11-trimethyl-2,6,10-dodecatrienol" RELATED [nist]
synonym: "Farnesol" RELATED [kegg.compound]
synonym: "farnesol" RELATED [uniprot_ft]
synonym: "farnesyl alcohol" RELATED [nist]
is_a: CHEBI:15734 ! primary alcohol
is_a: CHEBI:26199 ! polyprenol
is_a: CHEBI:36757 ! farnesane sesquiterpenoid
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite

[Term]
id: CHEBI:28616
name: carbamic acid
namespace: chebi_ontology
alt_id: CHEBI:22504
alt_id: CHEBI:23002
alt_id: CHEBI:3386
alt_id: CHEBI:44573
def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." []
subset: 3:STAR
subset: 3_STAR
synonym: "Aminoameisensaeure" RELATED [chebi]
synonym: "Aminoameisensaeure" RELATED [ChEBI]
synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND]
synonym: "Aminoformic acid" RELATED [kegg.compound]
synonym: "Carbamate" EXACT [KEGG_COMPOUND]
synonym: "Carbamate" RELATED [kegg.compound]
synonym: "Carbamate" RELATED [KEGG_COMPOUND]
synonym: "CARBAMIC ACID" EXACT [PDBeChem]
synonym: "CARBAMIC ACID" RELATED [pdb-ccd]
synonym: "Carbamic acid" EXACT [KEGG_COMPOUND]
synonym: "Carbamic acid" RELATED [kegg.compound]
synonym: "Carbamidsaeure" RELATED [ChEBI]
synonym: "Carbamidsaeure" RELATED [chebi]
xref: DrugBank:DB04261
xref: KEGG:C01563
xref: PDBeChem:OUT
xref: Wikipedia:Carbamic_acid
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:64708 ! one-carbon compound
relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:13941 ! carbamate

[Term]
id: CHEBI:28659
name: phosphorus atom
namespace: chebi_ontology
alt_id: CHEBI:26080
alt_id: CHEBI:8168
subset: 3:STAR
synonym: "15P" RELATED [iupac]
synonym: "fosforo" RELATED [chebi]
synonym: "P" RELATED [iupac, kegg.compound]
synonym: "Phosphor" RELATED [chebi]
synonym: "phosphore" RELATED [chebi]
synonym: "Phosphorus" EXACT [KEGG_COMPOUND]
synonym: "Phosphorus" RELATED [kegg.compound]
synonym: "phosphorus" RELATED [chebi]
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient

[Term]
id: CHEBI:28669
name: bacitracin
namespace: chebi_ontology
alt_id: CHEBI:22684
alt_id: CHEBI:2970
def: "A mixture of at least nine closely related homodetic cyclic peptides produced by <em>Bacillus subtilis</em> and <em>B. licheniformis</em>, which is particularly active against Gram-positive bacteria." []
subset: 3:STAR
synonym: "Bacitracin" RELATED [kegg.compound]
synonym: "bacitracins" RELATED [chebi]
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:35862 ! has part bacitracin A
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0018036 CHEBI:184381 ! bacitracin A zwitterion

[Term]
id: CHEBI:28694
name: copper atom
namespace: chebi_ontology
alt_id: CHEBI:23376
alt_id: CHEBI:3874
subset: 3:STAR
synonym: "29Cu" RELATED [iupac]
synonym: "cobre" RELATED [chebi]
synonym: "Copper" EXACT [KEGG_COMPOUND]
synonym: "Copper" RELATED [kegg.compound]
synonym: "copper" RELATED [chebi]
synonym: "Cu" RELATED [chebi, iupac]
synonym: "cuivre" RELATED [chebi]
synonym: "cuprum" RELATED [iupac]
synonym: "Kupfer" RELATED [chebi]
is_a: CHEBI:33366 ! copper group element atom
is_a: CHEBI:88184 ! metal allergen
relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite

[Term]
id: CHEBI:28817
name: dodecane
namespace: chebi_ontology
alt_id: CHEBI:25464
alt_id: CHEBI:41713
alt_id: CHEBI:4675
def: "A straight-chain alkane with 12 carbon atoms. It has been isolated from the essential oils of various plants including <em>Zingiber officinale</em> (ginger)." []
subset: 3:STAR
synonym: "Bihexyl" RELATED [hmdb]
synonym: "CH3-[CH2]10-CH3" RELATED [iupac]
synonym: "Dihexyl" RELATED [hmdb]
synonym: "DODECANE" EXACT [PDBeChem]
synonym: "DODECANE" RELATED [pdb-ccd]
synonym: "Dodecane" EXACT [KEGG_COMPOUND]
synonym: "Dodecane" RELATED [kegg.compound]
synonym: "dodecane" RELATED [uniprot_ft]
synonym: "Dodekan" RELATED [chebi]
synonym: "n-Dodecane" RELATED [kegg.compound]
is_a: CHEBI:18310 ! alkane
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite

[Term]
id: CHEBI:28864
name: tobramycin
namespace: chebi_ontology
alt_id: CHEBI:19849
alt_id: CHEBI:45933
alt_id: CHEBI:9610
def: "A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring." []
subset: 3:STAR
synonym: "3'-Deoxykanamycin B" RELATED [kegg.compound]
synonym: "Nebramycin 6" RELATED [chemidplus]
synonym: "Nebramycin factir 6" RELATED [kegg.compound]
synonym: "O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine" RELATED [chemidplus]
synonym: "Tobracin (TN)" RELATED [kegg.drug]
synonym: "Tobramycin" RELATED [kegg.compound]
synonym: "Tobrex (TN)" RELATED [kegg.drug]
is_a: CHEBI:22479 ! amino cyclitol glycoside
relationship: RO:0000087 CHEBI:27026 ! has role toxin
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0018033 CHEBI:73678 ! tobramycin(5+)
relationship: RO:0018038 CHEBI:28098 ! kanamycin B

[Term]
id: CHEBI:28866
name: tetracosanoic acid
namespace: chebi_ontology
alt_id: CHEBI:25467
alt_id: CHEBI:26892
alt_id: CHEBI:6458
def: "A C<small><sub>24</sub></small> straight-chain saturated fatty acid." []
subset: 3:STAR
synonym: "CH3-[CH2]22-COOH" RELATED [iupac]
synonym: "Lignoceric acid" RELATED [kegg.compound]
synonym: "Lignozerinsaeure" RELATED [chebi]
synonym: "n-tetracosanoic acid" RELATED [chebi]
synonym: "tetracosanic acid" RELATED [chebi]
synonym: "Tetracosanoic acid" EXACT [KEGG_COMPOUND]
synonym: "Tetracosanoic acid" RELATED [kegg.compound]
synonym: "Tetracosansaeure" RELATED [chebi]
synonym: "tetracosoic acid" RELATED [chebi]
synonym: "tetraeicosanoic acid" RELATED [chebi]
synonym: "tetraicosanoic acid" RELATED [chebi]
is_a: CHEBI:27283 ! very long-chain fatty acid
is_a: CHEBI:39418 ! straight-chain saturated fatty acid
relationship: RO:0000087 CHEBI:27311 ! has role volatile oil component
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:83146 ! has role Daphnia tenebrosa metabolite
relationship: RO:0018034 CHEBI:31014 ! tetracosanoate

[Term]
id: CHEBI:28868
name: fatty acid anion
namespace: chebi_ontology
alt_id: CHEBI:13634
alt_id: CHEBI:24022
alt_id: CHEBI:4985
def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." []
subset: 3:STAR
synonym: "a fatty acid" RELATED [uniprot_ft]
synonym: "acido graso anionico" RELATED [chebi]
synonym: "acidos grasos anionicos" RELATED [chebi]
synonym: "Alkanate" RELATED [kegg.compound]
synonym: "anion de l'acide gras" RELATED [chebi]
synonym: "Fatty acid anion" RELATED [kegg.compound]
synonym: "fatty acid anions" RELATED [chebi]
synonym: "Fettsaeureanion" RELATED [chebi]
synonym: "Fettsaeureanionen" RELATED [chebi]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:35366 ! fatty acid

[Term]
id: CHEBI:28909
name: iprodione
namespace: chebi_ontology
alt_id: CHEBI:24871
alt_id: CHEBI:8902
def: "An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an <em>N</em>-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide." []
subset: 3:STAR
synonym: "3-(3,5-dichlorophenyl)-1-(1-methylethyl)carbamoylhydantoin" RELATED [nist]
synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide" RELATED [chemidplus, umbbd.compound]
synonym: "3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxoimidazolidine-1-carboxamide" RELATED [iupac]
synonym: "3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide" RELATED [chemidplus]
synonym: "3-(3,5-dichlorophenyl)hydantoin-1-carboxylic acid isopropylamide" RELATED [chemidplus]
synonym: "Iprodione" RELATED [kegg.compound]
synonym: "Rovral" RELATED [kegg.compound]
synonym: "Rovrol" RELATED [kegg.compound]
is_a: CHEBI:24628 ! imidazolidine-2,4-dione
is_a: CHEBI:47857 ! ureas
is_a: CHEBI:87068 ! imidazole fungicide
is_a: CHEBI:87197 ! dichlorophenyl dicarboximide fungicide
relationship: RO:0000087 CHEBI:25491 ! has role nematicide
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:28915
name: fosfomycin
namespace: chebi_ontology
alt_id: CHEBI:24100
alt_id: CHEBI:42503
alt_id: CHEBI:8159
def: "A phosphonic acid having an (<i>R</i>,<i>S</i>)-1,2-epoxypropyl group attached to phosphorus." []
subset: 3:STAR
synonym: "(-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid" RELATED [chemidplus]
synonym: "(1R,2S)-epoxypropylphosphonic acid" RELATED [metacyc.compound]
synonym: "(2R-cis)-(3-Methyloxiranyl)phosphonic acid" RELATED [chemidplus]
synonym: "1R-cis-(1,2-epoxypropyl)phosphonic acid" RELATED [chebi]
synonym: "cis-(1R,2S)-epoxypropylphosphonic acid" RELATED [metacyc.compound]
synonym: "FCM" RELATED [kegg.drug]
synonym: "FOSFOMYCIN" RELATED [pdb-ccd]
synonym: "L-cis-1,2-epoxypropylphosphonic acid" RELATED [metacyc.compound]
synonym: "Phosphomycin" RELATED [chemidplus]
synonym: "phosphonemycin" RELATED [metacyc.compound]
synonym: "Phosphonomycin" RELATED [kegg.compound]
is_a: CHEBI:26069 ! phosphonic acids
is_a: CHEBI:32955 ! epoxide
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0000087 CHEBI:78379 ! has role EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
relationship: RO:0018034 CHEBI:62247 ! (1R,2S)-epoxypropylphosphonate(1-)
relationship: RO:0018038 CHEBI:44976 ! phosphonic acid

[Term]
id: CHEBI:28938
name: ammonium
namespace: chebi_ontology
alt_id: CHEBI:22534
alt_id: CHEBI:49783
alt_id: CHEBI:7435
def: "An onium cation obtained by protonation of ammonia." []
subset: 3:STAR
subset: 3_STAR
synonym: "[NH4](+)" RELATED [molbase]
synonym: "[NH4](+)" RELATED [MolBase]
synonym: "ammonium" EXACT [ChEBI]
synonym: "ammonium" RELATED [chebi]
synonym: "ammonium cation" RELATED [ChemIDplus]
synonym: "ammonium cation" RELATED [chemidplus]
synonym: "ammonium ion" RELATED [PDBeChem]
synonym: "ammonium ion" RELATED [pdb-ccd]
synonym: "Ammonium(1+)" RELATED [chemidplus]
synonym: "Ammonium(1+)" RELATED [ChemIDplus]
synonym: "NH(4)(+)" RELATED [uniprot_ft]
synonym: "NH4(+)" RELATED [IUPAC, UniProt]
synonym: "NH4(+)" RELATED [iupac]
synonym: "NH4+" RELATED [kegg.compound]
synonym: "NH4+" RELATED [KEGG_COMPOUND]
xref: KEGG:C01342
xref: MetaCyc:AMMONIUM
xref: MolBase:929
xref: PDBeChem:NH4
xref: Wikipedia:Ammonium
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:50313 ! onium cation
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:16134 ! ammonia

[Term]
id: CHEBI:28963
name: amino sugar
namespace: chebi_ontology
alt_id: CHEBI:22481
alt_id: CHEBI:22530
alt_id: CHEBI:2662
def: "Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." []
subset: 3:STAR
synonym: "amino sugars" RELATED [chebi]
synonym: "aminosugar" RELATED [chebi]
synonym: "Aminosugars" RELATED [kegg.compound]
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:28965
name: dicarboxylic acid dianion
namespace: chebi_ontology
alt_id: CHEBI:13632
alt_id: CHEBI:23688
alt_id: CHEBI:23689
alt_id: CHEBI:38711
def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." []
subset: 3:STAR
synonym: "a dicarboxylate" RELATED [uniprot_ft]
synonym: "dicarboxylate" RELATED [chebi]
synonym: "dicarboxylates" RELATED [chebi]
synonym: "dicarboxylic acid dianion" RELATED [chebi]
synonym: "dicarboxylic acid dianions" RELATED [chebi]
is_a: CHEBI:35693 ! dicarboxylic acid anion
is_a: CHEBI:38716 ! carboxylic acid dianion

[Term]
id: CHEBI:28971
name: ampicillin
namespace: chebi_ontology
alt_id: CHEBI:22536
alt_id: CHEBI:2683
alt_id: CHEBI:40648
alt_id: CHEBI:45042
def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID" RELATED [pdb-ccd]
synonym: "(2S,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [pdb-ccd]
synonym: "6-(D-(2-amino-2-phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid" RELATED [chemidplus]
synonym: "ABPC" RELATED [chebi]
synonym: "aminobenzylpenicillin" RELATED [drugbank]
synonym: "AMP" RELATED [chebi]
synonym: "Ampicillin" RELATED [kegg.compound]
synonym: "ampicillin acid" RELATED [drugbank]
synonym: "ampicillin anhydrous" RELATED [drugbank]
synonym: "Anhydrous ampicillin" RELATED [kegg.compound]
synonym: "AP" RELATED [chebi]
synonym: "D-(-)-6-(alpha-aminophenylacetamido)penicillanic acid" RELATED [chemidplus]
synonym: "D-(-)-ampicillin" RELATED [chemidplus]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:50658 ! ampicillin(1-)

[Term]
id: CHEBI:28976
name: carbonic acid
namespace: chebi_ontology
alt_id: CHEBI:13351
alt_id: CHEBI:23017
alt_id: CHEBI:23744
alt_id: CHEBI:3401
subset: 3:STAR
synonym: "[CO(OH)2]" RELATED [iupac]
synonym: "Carbonic acid" EXACT [KEGG_COMPOUND]
synonym: "Carbonic acid" RELATED [kegg.compound]
synonym: "Dihydrogen carbonate" RELATED [kegg.compound]
synonym: "H2CO3" RELATED [iupac, kegg.compound]
synonym: "Koehlensaeure" RELATED [chebi]
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36961 ! chalcocarbonic acid
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0018034 CHEBI:17544 ! hydrogencarbonate

[Term]
id: CHEBI:29007
name: ceftriaxone
namespace: chebi_ontology
alt_id: CHEBI:23059
alt_id: CHEBI:3513
alt_id: CHEBI:446214
def: "A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups." []
subset: 3:STAR
synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "rocephin" RELATED [chebi]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:36816 ! oxime O-ether
is_a: CHEBI:38418 ! 1,3-thiazoles
is_a: CHEBI:39410 ! 1,2,4-triazines
relationship: RO:0000087 CHEBI:35625 ! has role EC 3.5.2.6 (beta-lactamase) inhibitor
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:53658 ! ceftriaxone(1-)

[Term]
id: CHEBI:29013
name: fusidic acid
namespace: chebi_ontology
alt_id: CHEBI:24133
alt_id: CHEBI:42742
alt_id: CHEBI:5201
def: "A steroid antibiotic that is isolated from the fermentation broth of <em>Fusidium coccineum</em>." []
subset: 3:STAR
synonym: "fucidic acid" RELATED [chebi]
synonym: "Fucidin acid" RELATED [chemidplus]
synonym: "Fusidic acid" RELATED [kegg.compound]
synonym: "Fusidine" RELATED [chemidplus]
synonym: "Ramycin" RELATED [chemidplus]
is_a: CHEBI:19129 ! 11alpha-hydroxy steroid
is_a: CHEBI:26761 ! steroid antibiotic
is_a: CHEBI:35915 ! sterol ester
is_a: CHEBI:36835 ! 3alpha-hydroxy steroid
is_a: CHEBI:47891 ! steroid acid
is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77194 ! has role EC 2.7.1.33 (pantothenate kinase) inhibitor
relationship: RO:0018034 CHEBI:71321 ! fusidate
relationship: RO:0018040 CHEBI:35515 ! 5alpha-cholestane

[Term]
id: CHEBI:29036
name: copper(2+)
namespace: chebi_ontology
alt_id: CHEBI:20882
alt_id: CHEBI:23380
alt_id: CHEBI:49550
def: "An ion of copper carrying a double positive charge." []
subset: 3:STAR
synonym: "COPPER (II) ION" RELATED [pdb-ccd]
synonym: "copper(II) cation" EXACT [ChEBI]
synonym: "copper(II) cation" RELATED [chebi]
synonym: "copper, ion (Cu2+)" RELATED [chemidplus]
synonym: "Cu(2+)" RELATED [uniprot_ft]
synonym: "Cu(II)" RELATED [chebi]
synonym: "Cu2+" RELATED [chebi]
synonym: "cupric ion" RELATED [chebi]
is_a: CHEBI:23378 ! copper cation
is_a: CHEBI:30412 ! monoatomic dication
is_a: CHEBI:60240 ! divalent metal cation

[Term]
id: CHEBI:29067
name: carboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:13626
alt_id: CHEBI:13945
alt_id: CHEBI:23026
alt_id: CHEBI:58657
def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." []
subset: 3:STAR
subset: 3_STAR
synonym: "a carboxylate" RELATED [uniprot_ft]
synonym: "a carboxylate" RELATED [UniProt]
synonym: "carboxylic acid anions" RELATED [ChEBI]
synonym: "carboxylic acid anions" RELATED [chebi]
synonym: "carboxylic anions" RELATED [ChEBI]
synonym: "carboxylic anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid
relationship: RO:0018033 CHEBI:33575 ! carboxylic acid

[Term]
id: CHEBI:29101
name: sodium(1+)
namespace: chebi_ontology
alt_id: CHEBI:26717
alt_id: CHEBI:49766
alt_id: CHEBI:9175
def: "A monoatomic monocation obtained from sodium." []
subset: 3:STAR
synonym: "Na(+)" RELATED [iupac, uniprot_ft]
synonym: "Na+" RELATED [kegg.compound]
synonym: "SODIUM ION" RELATED [pdb-ccd]
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37246 ! elemental sodium
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:29103
name: potassium(1+)
namespace: chebi_ontology
alt_id: CHEBI:26219
alt_id: CHEBI:49685
alt_id: CHEBI:8345
def: "A monoatomic monocation obtained from potassium." []
subset: 3:STAR
synonym: "K(+)" RELATED [iupac, uniprot_ft]
synonym: "K+" RELATED [kegg.compound]
synonym: "POTASSIUM ION" RELATED [pdb-ccd]
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37247 ! elemental potassium
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:29192
name: hydrogenperoxide(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "[HO2](-)" RELATED [chebi]
synonym: "HO2(-)" RELATED [iupac]
synonym: "HOO anion" RELATED [nist]
synonym: "HOO(-)" RELATED [chebi]
synonym: "hydrogenperoxide(1-)" RELATED [iupac]
is_a: CHEBI:33693 ! oxygen hydride
relationship: RO:0018033 CHEBI:16240 ! hydrogen peroxide

[Term]
id: CHEBI:29214
name: sulfonic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "[SHO2(OH)]" RELATED [iupac]
synonym: "acide sulfonique" RELATED [chebi]
synonym: "HSHO3" RELATED [iupac]
synonym: "Sulfonsaeure" RELATED [chebi]
synonym: "sulphonic acid" RELATED [chebi]
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: RO:0018034 CHEBI:33543 ! sulfonate
relationship: RO:0018036 CHEBI:48854 ! sulfurous acid

[Term]
id: CHEBI:29256
name: thiol
namespace: chebi_ontology
alt_id: CHEBI:13443
alt_id: CHEBI:13696
alt_id: CHEBI:17366
alt_id: CHEBI:26969
alt_id: CHEBI:8766
alt_id: CHEBI:9556
def: "An organosulfur compound in which a thiol group, ‒SH, is attached to a carbon atom of any aliphatic or aromatic moiety." []
subset: 3:STAR
synonym: "a thiol" RELATED [uniprot_ft]
synonym: "Mercaptan" RELATED [kegg.compound]
synonym: "mercaptans" RELATED [chebi]
synonym: "Merkaptan" RELATED [chebi]
synonym: "RSH" RELATED [iupac]
synonym: "Thiol" EXACT [KEGG_COMPOUND]
synonym: "Thiol" RELATED [kegg.compound]
synonym: "thiols" EXACT [ChEBI]
synonym: "thiols" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound
relationship: BFO:0000051 CHEBI:29917 ! has part thiol group

[Term]
id: CHEBI:29258
name: dihydrogenphosphite
namespace: chebi_ontology
def: "A monovalent inorganic anion obtained by deprotonation of phosphorous acid." []
subset: 3:STAR
synonym: "[PO(OH)2] (-)" RELATED [iupac]
synonym: "dihydrogen phosphite" RELATED [chebi]
synonym: "H2PO3(-)" RELATED [iupac]
is_a: CHEBI:26045 ! phosphite ion
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: RO:0018033 CHEBI:36361 ! phosphorous acid
relationship: RO:0018034 CHEBI:29259 ! hydrogenphosphite

[Term]
id: CHEBI:29259
name: hydrogenphosphite
namespace: chebi_ontology
def: "A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid." []
subset: 3:STAR
synonym: "[PO2(OH)](2-)" RELATED [iupac]
synonym: "HPO3(2-)" RELATED [iupac]
synonym: "hydrogen phosphite" RELATED [iupac]
is_a: CHEBI:26045 ! phosphite ion
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0018033 CHEBI:29258 ! dihydrogenphosphite
relationship: RO:0018034 CHEBI:45064 ! phosphite(3-)

[Term]
id: CHEBI:29277
name: dinitride(2-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "N2(2-)" RELATED [iupac]
is_a: CHEBI:33266 ! diatomic nitrogen
relationship: RO:0018033 CHEBI:30103 ! diazenide

[Term]
id: CHEBI:29281
name: alkyl sulfate
namespace: chebi_ontology
alt_id: CHEBI:13810
alt_id: CHEBI:22325
alt_id: CHEBI:2583
subset: 3:STAR
synonym: "alkyl sulfates" RELATED [chebi]
is_a: CHEBI:25704 ! organic sulfate
is_a: CHEBI:26819 ! sulfuric ester
relationship: RO:0018034 CHEBI:83414 ! alkyl sulfate(1-)

[Term]
id: CHEBI:29337
name: azanide
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "NH2(-)" RELATED [IUPAC]
synonym: "NH2(-)" RELATED [iupac]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-)
relationship: is_conjugate_base_of CHEBI:16134 ! ammonia
relationship: RO:0018033 CHEBI:16134 ! ammonia
relationship: RO:0018034 CHEBI:29340 ! hydridonitrate(2-)

[Term]
id: CHEBI:29340
name: hydridonitrate(2-)
namespace: chebi_ontology
def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." []
subset: 3:STAR
subset: 3_STAR
synonym: "imide" RELATED [IUPAC]
synonym: "imide" RELATED [iupac]
synonym: "NH(2-)" RELATED [IUPAC]
synonym: "NH(2-)" RELATED [iupac]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: is_conjugate_base_of CHEBI:29337 ! azanide
relationship: RO:0018033 CHEBI:29337 ! azanide

[Term]
id: CHEBI:29347
name: monocarboxylic acid amide
namespace: chebi_ontology
alt_id: CHEBI:13211
alt_id: CHEBI:22207
alt_id: CHEBI:25383
alt_id: CHEBI:6977
def: "A carboxamide derived from a monocarboxylic acid." []
subset: 3:STAR
synonym: "monocarboxylic acid amides" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:29369
name: peroxy group
namespace: chebi_ontology
subset: 3:STAR
synonym: "-OO-" RELATED [iupac]
is_a: CHEBI:33246 ! inorganic group

[Term]
id: CHEBI:29534
name: avermectin B1a
namespace: chebi_ontology
subset: 3:STAR
synonym: "abamectin component B1a" RELATED [chemidplus]
synonym: "Avermectin B1a" RELATED [kegg.compound]
is_a: CHEBI:50344 ! avermectin

[Term]
id: CHEBI:29537
name: avermectin B1b
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside" RELATED [iupac]
synonym: "abamectin component B1b" RELATED [chemidplus]
synonym: "Avermectin B1b" RELATED [kegg.compound]
is_a: CHEBI:50344 ! avermectin

[Term]
id: CHEBI:2955
name: azithromycin
namespace: chebi_ontology
alt_id: CHEBI:46596
def: "A macrolide antibiotic useful for the treatment of bacterial infections." []
subset: 3:STAR
synonym: "(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one" RELATED [chemidplus]
is_a: CHEBI:25105 ! macrolide antibiotic
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0018033 CHEBI:231550 ! azithromycin(2+)

[Term]
id: CHEBI:29687
name: teicoplanin
namespace: chebi_ontology
def: "A complex mixture of related natural products isolated from the fermentation broth of a strain of <em>Actinoplanes teichomyceticus</em> comprising five major components (teicoplanin A<small><sub>2</sub></small>-1 through A<small><sub>2</sub></small>-5), a hydrolysis component (teicoplanin A<small><sub>3</sub></small>-1), and four minor components (teicoplanin R<small><sub>S</sub></small>-1 through R<small><sub>S</sub></small>-4). An antibiotic with a similar spectrum of activity to vancomycin, it is used to treat serious Gram-positive bacterial infections, including methicillin-resistant <em>Staphylococcus aureus</em> and <em>Enterococcus faecalis</em>." []
subset: 3:STAR
synonym: "antibiotic 8327A" RELATED [chemidplus]
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:34995 ! has part teicoplanin A2-1
relationship: BFO:0000051 CHEBI:34996 ! has part teicoplanin A2-3
relationship: BFO:0000051 CHEBI:34997 ! has part teicoplanin A2-4
relationship: BFO:0000051 CHEBI:34998 ! has part teicoplanin A2-5
relationship: BFO:0000051 CHEBI:34999 ! has part teicoplanin A3-1
relationship: BFO:0000051 CHEBI:85251 ! has part teicoplanin A2-2
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CHEBI:29688
name: telithromycin
namespace: chebi_ontology
alt_id: CHEBI:46029
subset: 2:STAR
synonym: "(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside" RELATED [pdb-ccd]
synonym: "HMR 3647" RELATED [drugcentral]
synonym: "HMR-3647" RELATED [kegg.compound]
synonym: "HMR3647" RELATED [kegg.compound]
synonym: "RU 66647" RELATED [drugcentral]
synonym: "RU-66647" RELATED [kegg.compound]
synonym: "RU66647" RELATED [kegg.compound]
synonym: "TELITHROMYCIN" RELATED [pdb-ccd]
synonym: "Telithromycin" RELATED [kegg.compound]
is_a: CHEBI:28963 ! amino sugar

[Term]
id: CHEBI:29699
name: tunicamycin
namespace: chebi_ontology
def: "A mixture of antiviral nucleoside antibiotics produced by <em>Streptomyces lysosuperificus</em>. It contains at least 10 homologues comprising uracil, <em>N</em>-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine.  The homologues vary in the composition of the fatty acid moiety." []
subset: 3:STAR
synonym: "Tunicamycin" RELATED [kegg.compound]
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:64228 ! has part tunicamycin A0
relationship: BFO:0000051 CHEBI:64245 ! has part tunicamycin A1
relationship: BFO:0000051 CHEBI:64246 ! has part tunicamycin A2
relationship: BFO:0000051 CHEBI:64248 ! has part tunicamycin B1
relationship: BFO:0000051 CHEBI:64250 ! has part tunicamycin B2
relationship: BFO:0000051 CHEBI:64255 ! has part tunicamycin B3
relationship: BFO:0000051 CHEBI:64256 ! has part tunicamycin C1
relationship: BFO:0000051 CHEBI:64257 ! has part tunicamycin C2
relationship: BFO:0000051 CHEBI:64271 ! has part tunicamycin D1
relationship: BFO:0000051 CHEBI:64272 ! has part tunicamycin D2
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0000087 CHEBI:64237 ! has role EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor

[Term]
id: CHEBI:29700
name: tylactone
namespace: chebi_ontology
alt_id: CHEBI:76805
def: "A 16-membererd macrolide that is the aglycone of the antibiotic 5-<em>O</em>-β-<small>D</small>-mycaminosyltylactone." []
subset: 3:STAR
synonym: "20-Deoxo-12,13-desepoxy-12,13-dehydrorosaranolide" RELATED [chemidplus]
synonym: "20-deoxo-23-deoxytylonolide" RELATED [chemidplus]
synonym: "20-Dsdr" RELATED [chemidplus]
synonym: "Protylonolide" RELATED [kegg.compound]
synonym: "Tylactone" RELATED [kegg.compound]
synonym: "tylactone" RELATED [uniprot_ft]
is_a: CHEBI:23824 ! diol
is_a: CHEBI:25106 ! macrolide
is_a: CHEBI:51689 ! enone
relationship: RO:0000087 CHEBI:25212 ! has role metabolite

[Term]
id: CHEBI:29785
name: nitro group
namespace: chebi_ontology
subset: 3:STAR
synonym: "-NO2" RELATED [iupac]
is_a: CHEBI:33246 ! inorganic group
is_a: CHEBI:51144 ! nitrogen group

[Term]
id: CHEBI:29917
name: thiol group
namespace: chebi_ontology
alt_id: CHEBI:26821
alt_id: CHEBI:29916
subset: 3:STAR
synonym: "-SH" RELATED [iupac]
synonym: "HS-" RELATED [iupac]
synonym: "mercapto group" RELATED [chebi]
synonym: "Mercaptogruppe" RELATED [chebi]
synonym: "Merkaptogruppe" RELATED [chebi]
synonym: "sulfhydryl group" RELATED [chebi]
synonym: "Sulfhydrylgruppe" RELATED [chebi]
synonym: "sulphydryl group" RELATED [chebi]
synonym: "thiol group" RELATED [uniprot_ft]
synonym: "Thiolgruppe" RELATED [chebi]
is_a: CHEBI:33246 ! inorganic group
relationship: RO:0018037 CHEBI:16136 ! hydrogen sulfide

[Term]
id: CHEBI:29919
name: hydrosulfide
namespace: chebi_ontology
subset: 3:STAR
synonym: "HS anion" RELATED [nist]
synonym: "HS(-)" RELATED [iupac]
synonym: "hydrogen sulfide" RELATED [uniprot_ft]
synonym: "hydrosulfide" RELATED [iupac]
is_a: CHEBI:33535 ! sulfur hydride
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:16136 ! hydrogen sulfide
relationship: RO:0018034 CHEBI:15138 ! sulfide(2-)

[Term]
id: CHEBI:29922
name: sulfo group
namespace: chebi_ontology
subset: 3:STAR
synonym: "-S(O)2(OH)" RELATED [iupac]
synonym: "SULFO GROUP" RELATED [pdb-ccd]
is_a: CHEBI:33246 ! inorganic group
relationship: RO:0018037 CHEBI:29214 ! sulfonic acid

[Term]
id: CHEBI:30089
name: acetate
namespace: chebi_ontology
alt_id: CHEBI:13704
alt_id: CHEBI:22165
alt_id: CHEBI:40480
def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." []
subset: 3:STAR
synonym: "acetate" RELATED [uniprot_ft]
synonym: "ACETATE ION" RELATED [pdb-ccd]
synonym: "acetic acid, ion(1-)" RELATED [chemidplus]
synonym: "Azetat" RELATED [chebi]
synonym: "CH3-COO(-)" RELATED [iupac]
synonym: "Ethanoat" RELATED [chebi]
synonym: "ethanoate" RELATED [chebi]
synonym: "MeCO2 anion" RELATED [nist]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:15366 ! acetic acid

[Term]
id: CHEBI:30096
name: diazene
namespace: chebi_ontology
subset: 3:STAR
synonym: "Diimide" RELATED [nist]
synonym: "HN=NH" RELATED [iupac]
is_a: CHEBI:35106 ! nitrogen hydride
relationship: RO:0018034 CHEBI:30103 ! diazenide

[Term]
id: CHEBI:30103
name: diazenide
namespace: chebi_ontology
subset: 3:STAR
synonym: "N=NH(-)" RELATED [iupac]
is_a: CHEBI:35106 ! nitrogen hydride
relationship: RO:0018033 CHEBI:30096 ! diazene
relationship: RO:0018034 CHEBI:29277 ! dinitride(2-)

[Term]
id: CHEBI:30106
name: azo group
namespace: chebi_ontology
subset: 3:STAR
synonym: "-N=N-" RELATED [iupac]
synonym: "azo" RELATED [iupac]
synonym: "diazene-1,2-diyl" RELATED [iupac]
is_a: CHEBI:33246 ! inorganic group
relationship: RO:0018037 CHEBI:30096 ! diazene

[Term]
id: CHEBI:3015
name: benomyl
namespace: chebi_ontology
def: "A member of the class of benzimidazoles that is the methyl ester of  [1-(butylcarbamoyl)-1<em>H</em>-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of <em>Ascomycetes</em> and <em>Fungi Imperfecti</em> in a wide range of crops." []
subset: 3:STAR
synonym: "1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat" RELATED [chemidplus]
synonym: "1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester" RELATED [chemidplus]
synonym: "1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol" RELATED [chemidplus]
synonym: "Benlate" RELATED [kegg.compound]
synonym: "Benomyl" RELATED [kegg.compound]
synonym: "Methyl 1-(butylamino)carbonyl-1H-benzimidazol-2-ylcarbamate" RELATED [hmdb]
synonym: "Methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate" RELATED [hmdb]
synonym: "Methyl N-(1-butylcarbamoyl-2-benzimidazole)carbamate" RELATED [hmdb]
is_a: CHEBI:62733 ! aromatic amide
is_a: CHEBI:87036 ! benzimidazole fungicide
is_a: CHEBI:87064 ! benzimidazolylcarbamate fungicide
relationship: RO:0000087 CHEBI:22153 ! has role acaricide
relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug
relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:30256
name: thiocarbonyl group
namespace: chebi_ontology
subset: 3:STAR
synonym: ">C=S" RELATED [iupac]
is_a: CHEBI:51422 ! organodiyl group

[Term]
id: CHEBI:30347
name: ethylenediamine
namespace: chebi_ontology
def: "An alkane-α,ω-diamine in which the alkane is ethane." []
subset: 3:STAR
synonym: "1,2-ethanediamine" RELATED [iupac]
synonym: "en" RELATED [iupac]
synonym: "ethylenediamine" RELATED [iupac]
is_a: CHEBI:35411 ! alkane-alpha,omega-diamine
relationship: RO:0000087 CHEBI:51373 ! has role GABA agonist
relationship: RO:0018040 CHEBI:42266 ! ethane

[Term]
id: CHEBI:30412
name: monoatomic dication
namespace: chebi_ontology
alt_id: CHEBI:23856
alt_id: CHEBI:4665
subset: 3:STAR
synonym: "Divalent cation" RELATED [kegg.compound]
synonym: "divalent inorganic cations" RELATED [chebi]
synonym: "monoatomic dications" RELATED [chebi]
is_a: CHEBI:23906 ! monoatomic cation

[Term]
id: CHEBI:30488
name: sulfonium
namespace: chebi_ontology
subset: 3:STAR
synonym: "[SH3](+)" RELATED [chebi]
synonym: "H3S(+)" RELATED [iupac]
synonym: "H3S+" RELATED [nist]
synonym: "sulphonium" RELATED [chebi]
is_a: CHEBI:26830 ! sulfonium compound
is_a: CHEBI:33535 ! sulfur hydride
is_a: CHEBI:50313 ! onium cation
relationship: RO:0018034 CHEBI:16136 ! hydrogen sulfide

[Term]
id: CHEBI:30746
name: benzoic acid
namespace: chebi_ontology
alt_id: CHEBI:22722
alt_id: CHEBI:3029
alt_id: CHEBI:41051
def: "A compound comprising a benzene ring core carrying a carboxylic acid substituent." []
subset: 3:STAR
synonym: "acide benzoique" RELATED [chebi]
synonym: "Aromatic carboxylic acid" RELATED [kegg.compound]
synonym: "Benzenecarboxylic acid" RELATED [kegg.compound]
synonym: "Benzeneformic acid" RELATED [hmdb]
synonym: "Benzenemethanoic acid" RELATED [hmdb]
synonym: "Benzoesaeure" RELATED [chebi]
synonym: "BENZOIC ACID" EXACT [PDBeChem]
synonym: "BENZOIC ACID" RELATED [pdb-ccd]
synonym: "Benzoic acid" EXACT [KEGG_COMPOUND]
synonym: "Benzoic acid" RELATED [kegg.compound]
synonym: "Dracylic acid" RELATED [kegg.compound]
synonym: "E210" RELATED [chebi]
synonym: "Phenylcarboxylic acid" RELATED [hmdb]
synonym: "Phenylformic acid" RELATED [kegg.compound]
is_a: CHEBI:22723 ! benzoic acids
relationship: RO:0000087 CHEBI:64996 ! has role EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor
relationship: RO:0000087 CHEBI:65001 ! has role EC 3.1.1.3 (triacylglycerol lipase) inhibitor
relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:76967 ! has role human xenobiotic metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
relationship: RO:0018034 CHEBI:16150 ! benzoate

[Term]
id: CHEBI:30751
name: formic acid
namespace: chebi_ontology
alt_id: CHEBI:24082
alt_id: CHEBI:42460
alt_id: CHEBI:5145
def: "The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects." []
subset: 3:STAR
synonym: "Acide formique" RELATED [chemidplus]
synonym: "Ameisensaeure" RELATED [chemidplus]
synonym: "aminic acid" RELATED [chemidplus]
synonym: "bilorin" RELATED [chemidplus]
synonym: "FORMIC ACID" EXACT [PDBeChem]
synonym: "FORMIC ACID" RELATED [pdb-ccd]
synonym: "Formic acid" EXACT [KEGG_COMPOUND]
synonym: "Formic acid" RELATED [kegg.compound]
synonym: "formylic acid" RELATED [chemidplus]
synonym: "H-COOH" RELATED [iupac]
synonym: "HCO2H" RELATED [chebi]
synonym: "HCOOH" RELATED [nist]
synonym: "hydrogen carboxylic acid" RELATED [chemidplus]
synonym: "Methanoic acid" RELATED [kegg.compound]
synonym: "methoic acid" RELATED [chebi]
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:48356 ! has role protic solvent
relationship: RO:0000087 CHEBI:74783 ! has role astringent
relationship: RO:0018034 CHEBI:15740 ! formate

[Term]
id: CHEBI:30762
name: salicylate
namespace: chebi_ontology
alt_id: CHEBI:15061
alt_id: CHEBI:26595
def: "A monohydroxybenzoate that is the conjugate base of salicylic acid." []
subset: 3:STAR
synonym: "2-hydroxybenzoic acid ion(1-)" RELATED [chemidplus]
synonym: "o-hydroxybenzoate" RELATED [chemidplus]
synonym: "sal" RELATED [iupac]
synonym: "Salicylate" RELATED [kegg.compound]
synonym: "salicylate" RELATED [uniprot_ft]
is_a: CHEBI:25388 ! monohydroxybenzoate
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0018033 CHEBI:16914 ! salicylic acid

[Term]
id: CHEBI:30802
name: isophthalic acid
namespace: chebi_ontology
def: "A benzenedicarboxylic acid that is benzene substituted by carboxy groups at position 1 and 3. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and terephthalic acids." []
subset: 3:STAR
synonym: "IPA" RELATED [nist]
synonym: "m-benzenedicarboxylic acid" RELATED [nist]
synonym: "meta-benzenedicarboxylic acid" RELATED [chebi]
is_a: CHEBI:26094 ! benzenedicarboxylic acid
relationship: RO:0018034 CHEBI:30804 ! isophthalate(1-)

[Term]
id: CHEBI:30803
name: isophthalate(2-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "1,3-benzenedicarboxylate" RELATED [chebi]
synonym: "isophthalate" RELATED [iupac, uniprot_ft]
is_a: CHEBI:28965 ! dicarboxylic acid dianion
relationship: RO:0018033 CHEBI:30804 ! isophthalate(1-)

[Term]
id: CHEBI:30804
name: isophthalate(1-)
namespace: chebi_ontology
def: "A dicarboxylic acid monoanion that is the conjugate base of isophthalic acid." []
subset: 3:STAR
synonym: "hydrogen isophthalate" RELATED [iupac]
is_a: CHEBI:35695 ! dicarboxylic acid monoanion
relationship: RO:0018033 CHEBI:30802 ! isophthalic acid
relationship: RO:0018034 CHEBI:30803 ! isophthalate(2-)

[Term]
id: CHEBI:30879
name: alcohol
namespace: chebi_ontology
alt_id: CHEBI:13804
alt_id: CHEBI:22288
alt_id: CHEBI:2553
def: "A compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom." []
subset: 3:STAR
synonym: "Alcohol" RELATED [kegg.compound]
synonym: "an alcohol" RELATED [uniprot_ft]
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:30911
name: glucitol
namespace: chebi_ontology
alt_id: CHEBI:15093
alt_id: CHEBI:26724
alt_id: CHEBI:26726
alt_id: CHEBI:33795
alt_id: CHEBI:33796
alt_id: CHEBI:9201
subset: 3:STAR
synonym: "gulitol" RELATED [chebi]
synonym: "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" RELATED [iupac]
synonym: "Sorbitol" RELATED [kegg.compound]
is_a: CHEBI:24583 ! hexitol
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite

[Term]
id: CHEBI:30938
name: 6-aminopenicillanate
namespace: chebi_ontology
alt_id: CHEBI:12207
alt_id: CHEBI:20704
subset: 3:STAR
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:16705 ! 6-aminopenicillanic acid
relationship: RO:0018033 CHEBI:57869 ! 6-aminopenicillanic acid zwitterion

[Term]
id: CHEBI:31011
name: valerate
namespace: chebi_ontology
alt_id: CHEBI:14751
alt_id: CHEBI:25890
def: "A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals." []
subset: 3:STAR
synonym: "CH3-[CH2]3-COO(-)" RELATED [iupac]
synonym: "n-propylacetate" RELATED [chebi]
synonym: "pentanoate" RELATED [uniprot_ft]
synonym: "pentanoic acid, ion(1-)" RELATED [chemidplus]
is_a: CHEBI:58951 ! short-chain fatty acid anion
is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0018033 CHEBI:17418 ! valeric acid

[Term]
id: CHEBI:31014
name: tetracosanoate
namespace: chebi_ontology
def: "A straight-chain saturated fatty acid anion that is the conjugate base of tetracosanoic acid (lignoceric acid), formed by deprotonation of the carboxy group." []
subset: 3:STAR
synonym: "CH3-[CH2]22-COO(-)" RELATED [iupac]
synonym: "Lignocerat" RELATED [chebi]
synonym: "lignocerate" RELATED [iubmb]
synonym: "n-tetracosanoate" RELATED [chebi]
synonym: "tetracosanate" RELATED [chebi]
synonym: "Tetracosanoat" RELATED [chebi]
synonym: "tetracosanoate" RELATED [uniprot_ft]
synonym: "tetracosoate" RELATED [chebi]
synonym: "tetraeicosanoate" RELATED [chebi]
is_a: CHEBI:58950 ! very long-chain fatty acid anion
is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion
is_a: CHEBI:78128 ! fatty acid anion 24:0
is_a: CHEBI:83955 ! 2-saturated fatty acid anion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:28866 ! tetracosanoic acid

[Term]
id: CHEBI:31286
name: bifonazole
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of <i>R</i>- and <i>S</i>-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections." []
subset: 3:STAR
synonym: "(+-)-1-(p,alpha-Diphenylbenzyl)imidazole" RELATED [chemidplus]
synonym: "(+-)-bifonazole" RELATED [chebi]
synonym: "(+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole" RELATED [drugbank]
synonym: "(RS)-bifonazole" RELATED [chebi]
synonym: "1-((4-Biphenylyl)phenylmethyl)-1H-imidazole" RELATED [drugbank]
synonym: "1-(alpha-(4-Biphenylyl)benzyl)imidazole" RELATED [chemidplus]
synonym: "rac-bifonazole" RELATED [chebi]
synonym: "racemic bifonazole" RELATED [chebi]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87069 ! imidazole antifungal drug
relationship: BFO:0000051 CHEBI:78693 ! has part (R)-bifonazole
relationship: BFO:0000051 CHEBI:78694 ! has part (S)-bifonazole

[Term]
id: CHEBI:31577
name: ethylenediamine derivative
namespace: chebi_ontology
def: "Any organic amino compound that is a derivative of  ethylenediamine." []
subset: 3:STAR
synonym: "ethylenediamine derivatives" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound
relationship: RO:0018038 CHEBI:30347 ! ethylenediamine

[Term]
id: CHEBI:31927
name: nystatin A3
namespace: chebi_ontology
subset: 3:STAR
synonym: "nystatin A3" RELATED [kegg.compound]
is_a: CHEBI:59676 ! nystatins

[Term]
id: CHEBI:32066
name: Prothionamide
namespace: chebi_ontology
alt_id: CHEBI:93717
subset: 2:STAR
synonym: "2-Propylisonicotinylthioamide" RELATED [drugcentral]
synonym: "2-Propylthioisonicotinamide" RELATED [drugcentral]
synonym: "Prothionamide" RELATED [kegg.compound]
synonym: "prothionamide" RELATED [drugcentral]
synonym: "protionamid" RELATED [drugcentral]
is_a: CHEBI:26421 ! pyridines

[Term]
id: CHEBI:32158
name: streptomycin sulfate
namespace: chebi_ontology
subset: 2:STAR
synonym: "Streptomycin sulfate" RELATED [kegg.compound]
is_a: CHEBI:38012 ! aminoglycoside sulfate salt
relationship: RO:0018038 CHEBI:17076 ! streptomycin

[Term]
id: CHEBI:32161
name: sulfadimethoxine
namespace: chebi_ontology
def: "A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position." []
subset: 3:STAR
synonym: "2,4-dimethoxy-6-sulfanilamido-1,3-diazine" RELATED [chemidplus]
synonym: "2,6-dimethoxy-4-(p-aminobenzenesulfonamido)pyrimidine" RELATED [chemidplus]
synonym: "2,6-dimethoxy-4-sulfanilamidopyrimidine" RELATED [chemidplus]
synonym: "4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide" RELATED [chemidplus]
synonym: "6-sulfanilamido-2,4-dimethoxypyrimidine" RELATED [chemidplus]
synonym: "Abcid (TN)" RELATED [kegg.drug]
synonym: "Agribon (TN)" RELATED [kegg.drug]
synonym: "N(1)-(2,6-dimethoxy-4-pyrimidinyl)sulfanilamide" RELATED [chemidplus]
synonym: "Sulfadimethoxine" RELATED [kegg.drug]
synonym: "Sulfadimethoxydiazine" RELATED [chemidplus]
synonym: "Sulphadimethoxine" RELATED [chemidplus]
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:39447 ! pyrimidines
is_a: CHEBI:48975 ! substituted aniline
is_a: CHEBI:87228 ! sulfonamide antibiotic
relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
relationship: RO:0018038 CHEBI:45373 ! sulfanilamide

[Term]
id: CHEBI:32544
name: nicotinate
namespace: chebi_ontology
alt_id: CHEBI:14650
alt_id: CHEBI:22851
alt_id: CHEBI:25530
def: "A pyridinemonocarboxylate that is the conjugate base of nicotinic acid, arising from deprotonation of the carboxy group; major species at pH 7.3." []
subset: 3:STAR
synonym: "3-pyridinecarboxylate" RELATED [chebi]
synonym: "nicotinate" RELATED [uniprot_ft]
is_a: CHEBI:176839 ! vitamin B3
is_a: CHEBI:38181 ! pyridinemonocarboxylate
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0018033 CHEBI:15940 ! nicotinic acid

[Term]
id: CHEBI:32588
name: potassium chloride
namespace: chebi_ontology
def: "A metal chloride salt with a K(+) counterion." []
subset: 3:STAR
synonym: "[KCl]" RELATED [molbase]
synonym: "Kaliumchlorid" RELATED [chebi]
synonym: "KCl" RELATED [iupac]
synonym: "Monopotassium chloride" RELATED [drugbank]
synonym: "muriate of potash" RELATED [nist]
synonym: "sylvite" RELATED [chebi]
is_a: CHEBI:190303 ! inorganic potassium salt
is_a: CHEBI:36093 ! inorganic chloride
relationship: RO:0000087 CHEBI:228364 ! has role NMR chemical shift reference compound
relationship: RO:0000087 CHEBI:33287 ! has role fertilizer

[Term]
id: CHEBI:32600
name: tetracene
namespace: chebi_ontology
def: "An acene that consists of four <em>ortho</em>-fused benzene rings in a rectilinear arrangement." []
subset: 3:STAR
synonym: "2,3-benzanthracene" RELATED [nist]
synonym: "benz[b]anthracene" RELATED [nist]
synonym: "naphthacene" RELATED [iupac]
is_a: CHEBI:35297 ! acene
is_a: CHEBI:51270 ! tetracenes

[Term]
id: CHEBI:32845
name: serinate
namespace: chebi_ontology
def: "An α-amino-acid anion that is the conjugate base of serine." []
subset: 3:STAR
synonym: "2-amino-3-hydroxypropanoate" RELATED [iupac]
synonym: "serine anion" RELATED [jcbn]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018033 CHEBI:17822 ! serine

[Term]
id: CHEBI:32846
name: serinium
namespace: chebi_ontology
def: "An α-amino-acid cation that is the conjugate acid of serine." []
subset: 3:STAR
synonym: "1-carboxy-2-hydroxyethanaminium" RELATED [iupac]
synonym: "serine cation" RELATED [jcbn]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
relationship: RO:0018034 CHEBI:17822 ! serine

[Term]
id: CHEBI:32862
name: L-prolinate
namespace: chebi_ontology
def: "An optically active form of prolinate having <small>L</small>-configuration." []
subset: 3:STAR
synonym: "(2S)-pyrrolidine-2-carboxylate" RELATED [iupac]
synonym: "L-proline anion" RELATED [jcbn]
is_a: CHEBI:32871 ! prolinate
is_a: CHEBI:59814 ! L-alpha-amino acid anion
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:17203 ! L-proline
relationship: RO:0018039 CHEBI:32867 ! D-prolinate

[Term]
id: CHEBI:32863
name: secondary amine
namespace: chebi_ontology
alt_id: CHEBI:26618
alt_id: CHEBI:9078
def: "A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups." []
subset: 3:STAR
synonym: "R2NH" RELATED [iupac]
synonym: "Secondary amine" RELATED [kegg.compound]
synonym: "sekundaeres Amin" RELATED [chebi]
is_a: CHEBI:32952 ! amine
is_a: CHEBI:50995 ! secondary amino compound
relationship: RO:0018033 CHEBI:137419 ! secondary ammonium ion

[Term]
id: CHEBI:32864
name: L-prolinium
namespace: chebi_ontology
def: "An optically active form of prolinium having <small>L</small>-configuration." []
subset: 3:STAR
synonym: "(2S)-2-carboxypyrrolidinium" RELATED [iupac]
synonym: "L-proline cation" RELATED [jcbn]
is_a: CHEBI:32872 ! prolinium
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:17203 ! L-proline
relationship: RO:0018039 CHEBI:32868 ! D-prolinium

[Term]
id: CHEBI:32867
name: D-prolinate
namespace: chebi_ontology
def: "An optically active form of prolinate having <small>D</small>-configuration." []
subset: 3:STAR
synonym: "(2R)-pyrrolidine-2-carboxylate" RELATED [iupac]
synonym: "D-proline anion" RELATED [jcbn]
is_a: CHEBI:32871 ! prolinate
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:16313 ! D-proline
relationship: RO:0018039 CHEBI:32862 ! L-prolinate

[Term]
id: CHEBI:32868
name: D-prolinium
namespace: chebi_ontology
def: "An optically active form of prolinium having <small>D</small>-configuration." []
subset: 3:STAR
synonym: "(2R)-2-carboxypyrrolidinium" RELATED [iupac]
synonym: "D-proline cation" RELATED [jcbn]
is_a: CHEBI:32872 ! prolinium
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018034 CHEBI:16313 ! D-proline
relationship: RO:0018039 CHEBI:32864 ! L-prolinium

[Term]
id: CHEBI:32871
name: prolinate
namespace: chebi_ontology
def: "An α-amino-acid anion that is the conjugate base of proline, arising from deprotonation of the carboxy group." []
subset: 3:STAR
synonym: "pro(-)" RELATED [iupac]
synonym: "proline anion" RELATED [jcbn]
synonym: "pyrrolidine-2-carboxylate" RELATED [iupac]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:26271 ! proline

[Term]
id: CHEBI:32872
name: prolinium
namespace: chebi_ontology
def: "An α-amino-acid cation that is the conjugate acid of proline, arising from protonation of the amino group." []
subset: 3:STAR
synonym: "2-carboxypyrrolidinium" RELATED [iupac]
synonym: "H2pro(+)" RELATED [iupac]
synonym: "proline cation" RELATED [jcbn]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0018034 CHEBI:26271 ! proline

[Term]
id: CHEBI:32876
name: tertiary amine
namespace: chebi_ontology
alt_id: CHEBI:26879
alt_id: CHEBI:9458
def: "A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups." []
subset: 3:STAR
synonym: "R3N" RELATED [iupac]
synonym: "tertiaeres Amin" RELATED [chebi]
synonym: "Tertiary amine" RELATED [kegg.compound]
is_a: CHEBI:32952 ! amine
is_a: CHEBI:50996 ! tertiary amino compound

[Term]
id: CHEBI:32877
name: primary amine
namespace: chebi_ontology
alt_id: CHEBI:26263
alt_id: CHEBI:26265
alt_id: CHEBI:8407
alt_id: CHEBI:8409
def: "A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group." []
subset: 3:STAR
synonym: "primaeres Amin" RELATED [chebi]
synonym: "Primary amine" RELATED [kegg.compound]
synonym: "Primary monoamine" RELATED [kegg.compound]
synonym: "R-NH2" RELATED [iupac]
synonym: "RCH2NH2" RELATED [kegg.compound]
is_a: CHEBI:32952 ! amine
is_a: CHEBI:50994 ! primary amino compound

[Term]
id: CHEBI:32952
name: amine
namespace: chebi_ontology
alt_id: CHEBI:13814
alt_id: CHEBI:22474
alt_id: CHEBI:2641
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." []
subset: 3:STAR
subset: 3_STAR
synonym: "Amin" RELATED [ChEBI]
synonym: "Amin" RELATED [chebi]
synonym: "Amine" EXACT [KEGG_COMPOUND]
synonym: "Amine" RELATED [kegg.compound]
synonym: "Substituted amine" RELATED [KEGG_COMPOUND]
synonym: "Substituted amine" RELATED [kegg.compound]
xref: KEGG:C00706
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:32955
name: epoxide
namespace: chebi_ontology
alt_id: CHEBI:13828
alt_id: CHEBI:23930
alt_id: CHEBI:4812
def: "Any cyclic ether in which the oxygen atom forms part of a 3-membered ring." []
subset: 3:STAR
synonym: "Alkene oxide" RELATED [kegg.compound]
synonym: "an epoxide" RELATED [uniprot_ft]
synonym: "Epoxide" RELATED [kegg.compound]
synonym: "epoxides" RELATED [chebi]
synonym: "Olefin oxide" RELATED [kegg.compound]
is_a: CHEBI:37407 ! cyclic ether
relationship: RO:0018040 CHEBI:27561 ! oxirane

[Term]
id: CHEBI:32964
name: ornithinate
namespace: chebi_ontology
alt_id: CHEBI:11448
alt_id: CHEBI:19370
subset: 3:STAR
synonym: "ornithine anion" RELATED [jcbn]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:18257 ! ornithine
relationship: RO:0018038 CHEBI:31011 ! valerate

[Term]
id: CHEBI:32988
name: amide
namespace: chebi_ontology
alt_id: CHEBI:22473
alt_id: CHEBI:2633
def: "An amide is a derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3:STAR
subset: 3_STAR
synonym: "Amide" EXACT [KEGG_COMPOUND]
synonym: "Amide" RELATED [kegg.compound]
xref: KEGG:C00241
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:33173
name: benzimidazolide
namespace: chebi_ontology
subset: 3:STAR
synonym: "bim" RELATED [iupac]
synonym: "bzim" RELATED [iupac]
is_a: CHEBI:50335 ! organic nitrogen anion
relationship: RO:0018033 CHEBI:41275 ! 1H-benzimidazole

[Term]
id: CHEBI:33229
name: vitamin (role)
namespace: chebi_ontology
alt_id: CHEBI:10004
alt_id: CHEBI:27305
def: "A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term \"vitamines\" (from <em>vita</em> + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines." []
subset: 3:STAR
synonym: "vitamin" RELATED [chebi]
synonym: "vitamina" RELATED [chebi]
synonym: "vitaminas" RELATED [chebi]
synonym: "vitamine" RELATED [chebi]
synonym: "vitamines" RELATED [chebi]
synonym: "vitamins" RELATED [chebi]
synonym: "vitaminum" RELATED [chebi]
is_a: CHEBI:27027 ! micronutrient
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:33231
name: antitubercular agent
namespace: chebi_ontology
def: "A substance that kills or slows the growth of <em>Mycobacterium tuberculosis</em> and is used in the treatment of tuberculosis." []
subset: 3:STAR
synonym: "antitubercular" RELATED [chebi]
synonym: "antitubercular agents" RELATED [chebi]
synonym: "antitubercular drug" RELATED [chebi]
synonym: "antitubercular drugs" RELATED [chebi]
synonym: "tuberculostatic agent" RELATED [chebi]
is_a: CHEBI:64912 ! antimycobacterial drug

[Term]
id: CHEBI:33232
name: application
namespace: chebi_ontology
def: "Intended use of the molecular entity or part thereof by humans." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:33233
name: fundamental particle
namespace: chebi_ontology
def: "A particle not known to have substructure." []
subset: 3:STAR
subset: 3_STAR
synonym: "elementary particles" RELATED [chebi]
synonym: "elementary particles" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:33238
name: monoatomic entity
namespace: chebi_ontology
def: "A monoatomic entity is a molecular entity consisting of a single atom." []
subset: 3:STAR
synonym: "atomic entity" RELATED [chebi]
synonym: "monoatomic entities" RELATED [chebi]
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33240
name: coordination entity
namespace: chebi_ontology
def: "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." []
subset: 3:STAR
synonym: "coordination compounds" RELATED [chebi]
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33241
name: oxoacid derivative
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxoacid derivatives" RELATED [chebi]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: RO:0018038 CHEBI:24833 ! oxoacid

[Term]
id: CHEBI:33242
name: inorganic hydride
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "inorganic hydrides" RELATED [chebi]
synonym: "inorganic hydrides" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:33245
name: organic fundamental parent
namespace: chebi_ontology
def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." []
subset: 3:STAR
synonym: "organic fundamental parents" RELATED [chebi]
synonym: "organic parent hydrides" RELATED [chebi]
is_a: CHEBI:37175 ! organic hydride
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33246
name: inorganic group
namespace: chebi_ontology
def: "Any substituent group which does not contain carbon." []
subset: 3:STAR
subset: 3_STAR
synonym: "inorganic groups" RELATED [chebi]
synonym: "inorganic groups" RELATED [ChEBI]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:33247
name: organic group
namespace: chebi_ontology
def: "Any substituent group or skeleton containing carbon." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic groups" RELATED [chebi]
synonym: "organic groups" RELATED [ChEBI]
is_a: CHEBI:24433 ! group
relationship: is_conjugate_acid_of CHEBI:64775 ! organic anionic group
relationship: is_conjugate_base_of CHEBI:64769 ! organic cationic group
relationship: RO:0018033 CHEBI:64769 ! organic cationic group
relationship: RO:0018034 CHEBI:64775 ! organic anionic group

[Term]
id: CHEBI:33248
name: hydrocarbyl group
namespace: chebi_ontology
def: "A univalent group formed by removing a hydrogen atom from a hydrocarbon." []
subset: 3:STAR
synonym: "groupe hydrocarbyle" RELATED [iupac]
synonym: "grupo hidrocarbilo" RELATED [iupac]
synonym: "grupos hidrocarbilo" RELATED [iupac]
synonym: "hydrocarbyl group" RELATED [iupac]
is_a: CHEBI:33249 ! organyl group
relationship: RO:0018037 CHEBI:24632 ! hydrocarbon

[Term]
id: CHEBI:33249
name: organyl group
namespace: chebi_ontology
def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "groupe organyle" RELATED [IUPAC]
synonym: "groupe organyle" RELATED [iupac]
synonym: "grupo organilo" RELATED [IUPAC]
synonym: "grupo organilo" RELATED [iupac]
synonym: "grupos organilo" RELATED [iupac]
synonym: "grupos organilo" RELATED [IUPAC]
is_a: CHEBI:51447 ! organic univalent group

[Term]
id: CHEBI:33250
name: atom
namespace: chebi_ontology
alt_id: CHEBI:22671
alt_id: CHEBI:23907
def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
subset: 3:STAR
subset: 3_STAR
synonym: "atome" RELATED [IUPAC]
synonym: "atome" RELATED [iupac]
synonym: "atomo" RELATED [iupac]
synonym: "atomo" RELATED [IUPAC]
synonym: "atoms" RELATED [chebi]
synonym: "atoms" RELATED [ChEBI]
synonym: "atomus" RELATED [chebi]
synonym: "atomus" RELATED [ChEBI]
synonym: "element" RELATED [ChEBI]
synonym: "element" RELATED [chebi]
synonym: "elements" RELATED [ChEBI]
synonym: "elements" RELATED [chebi]
is_a: CHEBI:24431 ! chemical entity
relationship: BFO:0000051 CHEBI:10545 ! has part electron
relationship: BFO:0000051 CHEBI:33252 ! has part atomic nucleus

[Term]
id: CHEBI:33252
name: atomic nucleus
namespace: chebi_ontology
def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." []
subset: 3:STAR
subset: 3_STAR
synonym: "Atomkern" RELATED [ChEBI]
synonym: "Atomkern" RELATED [chebi]
synonym: "Kern" RELATED [ChEBI]
synonym: "Kern" RELATED [chebi]
synonym: "noyau" RELATED [IUPAC]
synonym: "noyau" RELATED [iupac]
synonym: "noyau atomique" RELATED [chebi]
synonym: "noyau atomique" RELATED [ChEBI]
synonym: "nuclei" RELATED [ChEBI]
synonym: "nuclei" RELATED [chebi]
synonym: "nucleo" RELATED [iupac]
synonym: "nucleo" RELATED [IUPAC]
synonym: "nucleo atomico" RELATED [ChEBI]
synonym: "nucleo atomico" RELATED [chebi]
synonym: "nucleus atomi" RELATED [ChEBI]
synonym: "nucleus atomi" RELATED [chebi]
is_a: CHEBI:36347 ! nuclear particle
relationship: BFO:0000051 CHEBI:33253 ! has part nucleon

[Term]
id: CHEBI:33253
name: nucleon
namespace: chebi_ontology
def: "Heavy nuclear particle: proton or neutron." []
subset: 3:STAR
subset: 3_STAR
synonym: "nucleon" EXACT [IUPAC]
synonym: "nucleon" RELATED [iupac]
synonym: "nucleons" RELATED [chebi]
synonym: "nucleons" RELATED [ChEBI]
synonym: "Nukleon" RELATED [chebi]
synonym: "Nukleon" RELATED [ChEBI]
synonym: "Nukleonen" RELATED [ChEBI]
synonym: "Nukleonen" RELATED [chebi]
is_a: CHEBI:36339 ! baryon
is_a: CHEBI:36347 ! nuclear particle

[Term]
id: CHEBI:33256
name: primary amide
namespace: chebi_ontology
def: "A derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3:STAR
subset: 3_STAR
synonym: "primary amide" EXACT [IUPAC]
synonym: "primary amide" RELATED [iupac]
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:33257
name: secondary amide
namespace: chebi_ontology
def: "A derivative of two oxoacids R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which two acyl groups are attached to the amino or substituted amino group." []
subset: 3:STAR
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:33259
name: elemental molecular entity
namespace: chebi_ontology
def: "A molecular entity all atoms of which have the same atomic number." []
subset: 3:STAR
synonym: "homoatomic entity" RELATED [chebi]
synonym: "homoatomic molecular entities" RELATED [chebi]
synonym: "homoatomic molecular entity" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:33261
name: organosulfur compound
namespace: chebi_ontology
alt_id: CHEBI:23010
alt_id: CHEBI:25714
def: "An organosulfur compound is a compound containing at least one carbon-sulfur bond." []
subset: 3:STAR
synonym: "organosulfur compound" RELATED [chebi]
synonym: "organosulfur compounds" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:33266
name: diatomic nitrogen
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:33267 ! elemental nitrogen

[Term]
id: CHEBI:33267
name: elemental nitrogen
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:33465 ! elemental pnictogen
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:33273
name: polyatomic anion
namespace: chebi_ontology
def: "An anion consisting of more than one atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "polyatomic anions" RELATED [chebi]
synonym: "polyatomic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36358 ! polyatomic ion

[Term]
id: CHEBI:33280
name: molecular messenger
namespace: chebi_ontology
subset: 3:STAR
synonym: "chemical messenger" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:33281
name: antimicrobial agent
namespace: chebi_ontology
alt_id: CHEBI:22582
def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." []
subset: 3:STAR
synonym: "antibiotic" RELATED [chebi]
synonym: "antibiotics" RELATED [chebi]
synonym: "Antibiotika" RELATED [chebi]
synonym: "Antibiotikum" RELATED [chebi]
synonym: "antibiotique" RELATED [iupac]
synonym: "antimicrobial" RELATED [chebi]
synonym: "antimicrobial agents" RELATED [chebi]
synonym: "antimicrobials" RELATED [chebi]
synonym: "microbicide" RELATED [chebi]
synonym: "microbicides" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:33282
name: antibacterial agent
namespace: chebi_ontology
def: "A substance (or active part thereof) that kills or slows the growth of bacteria." []
subset: 3:STAR
synonym: "antibacterial agents" RELATED [chebi]
synonym: "antibacterials" RELATED [chebi]
synonym: "bactericide" RELATED [chebi]
synonym: "bactericides" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:33284
name: nutrient
namespace: chebi_ontology
def: "A nutrient is a food component that an organism uses to survive and grow." []
subset: 3:STAR
subset: 3_STAR
synonym: "nutrients" RELATED [chebi]
synonym: "nutrients" RELATED [ChEBI]
is_a: CHEBI:78295 ! food component

[Term]
id: CHEBI:33285
name: heteroorganic entity
namespace: chebi_ontology
def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." []
subset: 3:STAR
subset: 3_STAR
synonym: "heteroorganic entities" RELATED [ChEBI]
synonym: "heteroorganic entities" RELATED [chebi]
synonym: "organoelement compounds" RELATED [chebi]
synonym: "organoelement compounds" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33286
name: agrochemical
namespace: chebi_ontology
def: "An agrochemical is a substance that is used in agriculture or horticulture." []
subset: 3:STAR
synonym: "agrichemical" RELATED [chebi]
synonym: "agrichemicals" RELATED [chebi]
synonym: "agricultural chemicals" RELATED [chebi]
synonym: "agrochemicals" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33287
name: fertilizer
namespace: chebi_ontology
def: "A fertilizer is any substance that is added to soil or water to assist the growth of plants." []
subset: 3:STAR
synonym: "fertiliser" RELATED [chebi]
synonym: "fertilizers" RELATED [chebi]
is_a: CHEBI:33286 ! agrochemical

[Term]
id: CHEBI:33292
name: fuel
namespace: chebi_ontology
def: "An energy-rich substance that can be transformed with release of usable energy." []
subset: 3:STAR
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33296
name: alkali metal molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms of an alkali metal." []
subset: 3:STAR
synonym: "alkali metal molecular entities" RELATED [chebi]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: BFO:0000051 CHEBI:22314 ! has part alkali metal atom

[Term]
id: CHEBI:33300
name: pnictogen
namespace: chebi_ontology
def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." []
subset: 3:STAR
subset: 3_STAR
synonym: "group 15 elements" RELATED [ChEBI]
synonym: "group 15 elements" RELATED [chebi]
synonym: "group V elements" RELATED [chebi]
synonym: "group V elements" RELATED [ChEBI]
synonym: "nitrogenoideos" RELATED [chebi]
synonym: "nitrogenoideos" RELATED [ChEBI]
synonym: "nitrogenoides" RELATED [chebi]
synonym: "nitrogenoides" RELATED [ChEBI]
synonym: "pnictogene" RELATED [ChEBI]
synonym: "pnictogene" RELATED [chebi]
synonym: "pnictogenes" RELATED [ChEBI]
synonym: "pnictogenes" RELATED [chebi]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33302
name: pnictogen molecular entity
namespace: chebi_ontology
def: "A p-block molecular entity containing any pnictogen." []
subset: 3:STAR
subset: 3_STAR
synonym: "pnictogen molecular entities" RELATED [chebi]
synonym: "pnictogen molecular entities" RELATED [ChEBI]
synonym: "pnictogen molecular entity" EXACT [ChEBI]
synonym: "pnictogen molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33300 ! has part pnictogen

[Term]
id: CHEBI:33303
name: chalcogen
namespace: chebi_ontology
def: "Any p-block element belonging to the group 16 family of the periodic table." []
subset: 3:STAR
subset: 3_STAR
synonym: "anfigeno" RELATED [chebi]
synonym: "anfigeno" RELATED [ChEBI]
synonym: "anfigenos" RELATED [chebi]
synonym: "anfigenos" RELATED [ChEBI]
synonym: "calcogeno" RELATED [ChEBI]
synonym: "calcogeno" RELATED [chebi]
synonym: "calcogenos" RELATED [chebi]
synonym: "calcogenos" RELATED [ChEBI]
synonym: "chalcogene" RELATED [ChEBI]
synonym: "chalcogene" RELATED [chebi]
synonym: "chalcogenes" RELATED [chebi]
synonym: "chalcogenes" RELATED [ChEBI]
synonym: "Chalkogen" RELATED [chebi]
synonym: "Chalkogen" RELATED [ChEBI]
synonym: "Chalkogene" RELATED [ChEBI]
synonym: "Chalkogene" RELATED [chebi]
synonym: "group 16 elements" RELATED [chebi]
synonym: "group 16 elements" RELATED [ChEBI]
synonym: "group VI elements" RELATED [chebi]
synonym: "group VI elements" RELATED [ChEBI]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33304
name: chalcogen molecular entity
namespace: chebi_ontology
def: "Any p-block molecular entity containing a chalcogen." []
subset: 3:STAR
subset: 3_STAR
synonym: "chalcogen compounds" RELATED [chebi]
synonym: "chalcogen compounds" RELATED [ChEBI]
synonym: "chalcogen molecular entities" RELATED [ChEBI]
synonym: "chalcogen molecular entities" RELATED [chebi]
synonym: "chalcogen molecular entity" EXACT [ChEBI]
synonym: "chalcogen molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33303 ! has part chalcogen

[Term]
id: CHEBI:33306
name: carbon group element atom
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "carbon group element" RELATED [ChEBI]
synonym: "carbon group element" RELATED [chebi]
synonym: "carbon group elements" RELATED [ChEBI]
synonym: "carbon group elements" RELATED [chebi]
synonym: "carbonoides" RELATED [chebi]
synonym: "carbonoides" RELATED [ChEBI]
synonym: "cristallogene" RELATED [ChEBI]
synonym: "cristallogene" RELATED [chebi]
synonym: "cristallogenes" RELATED [chebi]
synonym: "cristallogenes" RELATED [ChEBI]
synonym: "group IV elements" RELATED [ChEBI]
synonym: "group IV elements" RELATED [chebi]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33308
name: carboxylic ester
namespace: chebi_ontology
alt_id: CHEBI:13204
alt_id: CHEBI:23028
alt_id: CHEBI:3408
def: "An ester of a carboxylic acid, R<small><sup>1</small></sup>C(=O)OR<small><sup>2</small></sup>, where R<small><sup>1</small></sup> = H or organyl and R<small><sup>2</small></sup> = organyl." []
subset: 3:STAR
synonym: "a carboxylic ester" RELATED [uniprot_ft]
synonym: "carboxylic acid esters" RELATED [chebi]
synonym: "Carboxylic ester" RELATED [kegg.compound]
is_a: CHEBI:35701 ! ester
is_a: CHEBI:36586 ! carbonyl compound

[Term]
id: CHEBI:33318
name: main group element atom
namespace: chebi_ontology
def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." []
subset: 3:STAR
subset: 3_STAR
synonym: "Hauptgruppenelement" RELATED [ChEBI]
synonym: "Hauptgruppenelement" RELATED [chebi]
synonym: "Hauptgruppenelemente" RELATED [ChEBI]
synonym: "Hauptgruppenelemente" RELATED [chebi]
synonym: "main group element" RELATED [ChEBI]
synonym: "main group element" RELATED [chebi]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33338
name: aryl group
namespace: chebi_ontology
def: "A group derived from an arene by removal of a hydrogen atom from a ring carbon atom." []
subset: 3:STAR
synonym: "Arylgruppe" RELATED [chebi]
synonym: "groupe aryle" RELATED [iupac]
synonym: "grupos arilo" RELATED [iupac]
is_a: CHEBI:33248 ! hydrocarbyl group
relationship: RO:0018037 CHEBI:33658 ! arene

[Term]
id: CHEBI:33340
name: zinc group element atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "zinc group element" RELATED [chebi]
synonym: "zinc group elements" RELATED [chebi]
is_a: CHEBI:33561 ! d-block element atom

[Term]
id: CHEBI:33352
name: manganese group element atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "manganese group element" RELATED [chebi]
synonym: "manganese group elements" RELATED [chebi]
is_a: CHEBI:33561 ! d-block element atom

[Term]
id: CHEBI:33366
name: copper group element atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "coinage metals" RELATED [chebi]
synonym: "copper group element" RELATED [chebi]
synonym: "copper group elements" RELATED [chebi]
is_a: CHEBI:33561 ! d-block element atom

[Term]
id: CHEBI:33402
name: sulfur oxoacid
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxoacids of sulfur" RELATED [chebi]
synonym: "sulfur oxoacids" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33484 ! chalcogen oxoacid

[Term]
id: CHEBI:33405
name: hydracid
namespace: chebi_ontology
def: "A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." []
subset: 3:STAR
synonym: "hydracids" RELATED [chebi]
is_a: CHEBI:33608 ! hydrogen molecular entity
relationship: RO:0000087 CHEBI:39141 ! has role Bronsted acid

[Term]
id: CHEBI:33408
name: pnictogen oxoacid
namespace: chebi_ontology
subset: 3:STAR
synonym: "pnictogen oxoacids" RELATED [chebi]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid

[Term]
id: CHEBI:33424
name: sulfur oxoacid derivative
namespace: chebi_ontology
subset: 3:STAR
synonym: "sulfur oxoacid derivative" RELATED [chebi]
synonym: "sulfur oxoacid derivatives" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33241 ! oxoacid derivative

[Term]
id: CHEBI:33429
name: monoatomic monoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoatomic monoanions" RELATED [chebi]
is_a: CHEBI:23905 ! monoatomic anion
is_a: CHEBI:36830 ! monoanion

[Term]
id: CHEBI:33431
name: elemental chlorine
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:23117 ! chlorine molecular entity
is_a: CHEBI:33434 ! elemental halogen

[Term]
id: CHEBI:33432
name: monoatomic chlorine
namespace: chebi_ontology
subset: 3:STAR
synonym: "atomic chlorine" RELATED [chebi]
is_a: CHEBI:33431 ! elemental chlorine
is_a: CHEBI:33433 ! monoatomic halogen

[Term]
id: CHEBI:33433
name: monoatomic halogen
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoatomic halogens" RELATED [chebi]
is_a: CHEBI:33238 ! monoatomic entity

[Term]
id: CHEBI:33434
name: elemental halogen
namespace: chebi_ontology
subset: 3:STAR
synonym: "elemental halogen" RELATED [chebi]
synonym: "elemental halogens" RELATED [chebi]
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33447
name: phospho sugar
namespace: chebi_ontology
alt_id: CHEBI:15132
alt_id: CHEBI:16442
alt_id: CHEBI:25406
alt_id: CHEBI:26086
alt_id: CHEBI:9320
def: "Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid." []
subset: 3:STAR
synonym: "monosaccharide phosphates" RELATED [chebi]
synonym: "phospho sugar" RELATED [chebi]
synonym: "phospho sugars" RELATED [chebi]
synonym: "phosphorylated sugar" RELATED [chebi]
synonym: "phosphorylated sugars" RELATED [chebi]
synonym: "phosphosugar" RELATED [chebi]
synonym: "phosphosugars" RELATED [chebi]
is_a: CHEBI:26816 ! carbohydrate phosphate
is_a: CHEBI:63367 ! monosaccharide derivative

[Term]
id: CHEBI:33457
name: phosphorus oxoacid
namespace: chebi_ontology
def: "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." []
subset: 3:STAR
synonym: "oxoacids of phosphorus" RELATED [chebi]
synonym: "Oxosaeure des Phosphors" RELATED [chebi]
synonym: "phosphorus oxoacid" RELATED [chebi]
synonym: "phosphorus oxoacids" RELATED [chebi]
is_a: CHEBI:33408 ! pnictogen oxoacid
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives

[Term]
id: CHEBI:33459
name: pnictogen oxoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "pnictogen oxoanion" RELATED [chebi]
synonym: "pnictogen oxoanions" RELATED [chebi]
is_a: CHEBI:33302 ! pnictogen molecular entity
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33461
name: phosphorus oxoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxoanions of phosphorus" RELATED [chebi]
synonym: "phosphorus oxoanion" RELATED [chebi]
synonym: "phosphorus oxoanions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33459 ! pnictogen oxoanion

[Term]
id: CHEBI:33462
name: phosphonate(1-)
namespace: chebi_ontology
def: "A monovalent inorganic anion obtained by deprotonation of one of the two OH groups in phosphonic acid." []
subset: 3:STAR
synonym: "[PHO2(OH)](-)" RELATED [iupac]
synonym: "hydrogenphosphonate" RELATED [iupac]
is_a: CHEBI:33461 ! phosphorus oxoanion
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: RO:0018033 CHEBI:44976 ! phosphonic acid
relationship: RO:0018034 CHEBI:16215 ! phosphonate(2-)

[Term]
id: CHEBI:33465
name: elemental pnictogen
namespace: chebi_ontology
subset: 3:STAR
synonym: "elemental pnictogen" RELATED [chebi]
synonym: "elemental pnictogens" RELATED [chebi]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33259 ! elemental molecular entity
is_a: CHEBI:33302 ! pnictogen molecular entity

[Term]
id: CHEBI:33482
name: sulfur oxoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxoanions of sulfur" RELATED [chebi]
synonym: "sulfur oxoanion" RELATED [chebi]
synonym: "sulfur oxoanions" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33485 ! chalcogen oxoanion

[Term]
id: CHEBI:33484
name: chalcogen oxoacid
namespace: chebi_ontology
subset: 3:STAR
synonym: "chalcogen oxoacid" RELATED [chebi]
synonym: "chalcogen oxoacids" RELATED [chebi]
is_a: CHEBI:24833 ! oxoacid
relationship: RO:0000087 CHEBI:138103 ! has role inorganic acid

[Term]
id: CHEBI:33485
name: chalcogen oxoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "chalcogen oxoanion" RELATED [chebi]
synonym: "chalcogen oxoanions" RELATED [chebi]
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33497
name: transition element molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms of a transition element." []
subset: 3:STAR
synonym: "transition element molecular entities" RELATED [chebi]
synonym: "transition metal molecular entity" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
relationship: BFO:0000051 CHEBI:27081 ! has part transition element atom

[Term]
id: CHEBI:33504
name: alkali metal cation
namespace: chebi_ontology
subset: 3:STAR
synonym: "alkali metal cations" RELATED [chebi]
is_a: CHEBI:25213 ! metal cation

[Term]
id: CHEBI:33515
name: transition element cation
namespace: chebi_ontology
subset: 3:STAR
synonym: "transition element cations" RELATED [chebi]
synonym: "transition metal cation" RELATED [chebi]
is_a: CHEBI:25213 ! metal cation

[Term]
id: CHEBI:33521
name: metal atom
namespace: chebi_ontology
alt_id: CHEBI:25217
alt_id: CHEBI:6788
def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." []
subset: 3:STAR
synonym: "elemental metal" RELATED [chebi]
synonym: "elemental metals" RELATED [chebi]
synonym: "metal element" RELATED [chebi]
synonym: "metal elements" RELATED [chebi]
synonym: "metals" RELATED [chebi]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33535
name: sulfur hydride
namespace: chebi_ontology
subset: 3:STAR
synonym: "hydrides of sulfur" RELATED [chebi]
synonym: "sulfur hydride" RELATED [chebi]
synonym: "sulfur hydrides" RELATED [chebi]
synonym: "sulphur hydrides" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:36902 ! chalcogen hydride

[Term]
id: CHEBI:33543
name: sulfonate
namespace: chebi_ontology
def: "The sulfur oxoanion formed by deprotonation of sulfonic acid." []
subset: 3:STAR
synonym: "[SHO3](-)" RELATED [iupac]
synonym: "SHO3(-)" RELATED [iupac]
synonym: "sulfonates" RELATED [chebi]
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: RO:0018033 CHEBI:29214 ! sulfonic acid

[Term]
id: CHEBI:33551
name: organosulfonic acid
namespace: chebi_ontology
def: "An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon." []
subset: 3:STAR
synonym: "organosulfonic acids" RELATED [chebi]
synonym: "sulfonic acids" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:33552 ! sulfonic acid derivative
is_a: CHEBI:64709 ! organic acid
relationship: BFO:0000051 CHEBI:29922 ! has part sulfo group
relationship: BFO:0000051 CHEBI:33249 ! has part organyl group
relationship: RO:0018034 CHEBI:33554 ! organosulfonate oxoanion

[Term]
id: CHEBI:33552
name: sulfonic acid derivative
namespace: chebi_ontology
subset: 3:STAR
synonym: "derivatives of sulfonic acid" RELATED [chebi]
synonym: "sulfonic acid derivative" RELATED [chebi]
synonym: "sulfonic acid derivatives" RELATED [chebi]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
relationship: RO:0018038 CHEBI:29214 ! sulfonic acid

[Term]
id: CHEBI:33554
name: organosulfonate oxoanion
namespace: chebi_ontology
def: "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." []
subset: 3:STAR
synonym: "organosulfonate" RELATED [chebi]
synonym: "organosulfonate oxoanions" RELATED [chebi]
synonym: "organosulfonates" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0018033 CHEBI:33551 ! organosulfonic acid
relationship: RO:0018038 CHEBI:33543 ! sulfonate

[Term]
id: CHEBI:33555
name: arenesulfonic acid
namespace: chebi_ontology
def: "Organic derivatives of sulfonic acid in which the sulfo group is linked directly to carbon of an aryl group." []
subset: 3:STAR
synonym: "arenesulfonic acids" RELATED [chebi]
synonym: "arylsulfonic acid" RELATED [chebi]
synonym: "arylsulfonic acids" RELATED [chebi]
is_a: CHEBI:33551 ! organosulfonic acid
relationship: BFO:0000051 CHEBI:33338 ! has part aryl group
relationship: RO:0018034 CHEBI:22713 ! arenesulfonate oxoanion

[Term]
id: CHEBI:33558
name: alpha-amino-acid anion
namespace: chebi_ontology
def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "alpha-amino acid anion" RELATED [chebi]
synonym: "alpha-amino acid anion" RELATED [ChEBI]
synonym: "alpha-amino acid anions" RELATED [ChEBI]
synonym: "alpha-amino acid anions" RELATED [chebi]
synonym: "alpha-amino-acid anions" RELATED [ChEBI]
synonym: "alpha-amino-acid anions" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid
relationship: RO:0018033 CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:33559
name: s-block element atom
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "s-block element" RELATED [ChEBI]
synonym: "s-block element" RELATED [chebi]
synonym: "s-block elements" RELATED [ChEBI]
synonym: "s-block elements" RELATED [chebi]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33560
name: p-block element atom
namespace: chebi_ontology
def: "Any main group element atom belonging to the p-block of the periodic table." []
subset: 3:STAR
subset: 3_STAR
synonym: "p-block element" RELATED [ChEBI]
synonym: "p-block element" RELATED [chebi]
synonym: "p-block elements" RELATED [chebi]
synonym: "p-block elements" RELATED [ChEBI]
is_a: CHEBI:33318 ! main group element atom

[Term]
id: CHEBI:33561
name: d-block element atom
namespace: chebi_ontology
subset: 3:STAR
synonym: "d-block element" RELATED [chebi]
synonym: "d-block elements" RELATED [chebi]
is_a: CHEBI:27081 ! transition element atom

[Term]
id: CHEBI:33570
name: benzenediols
namespace: chebi_ontology
alt_id: CHEBI:22705
alt_id: CHEBI:22711
subset: 3:STAR
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:33572
name: resorcinols
namespace: chebi_ontology
def: "Any benzenediol in which the two hydroxy groups are <em>meta</em> to one another." []
subset: 3:STAR
is_a: CHEBI:33570 ! benzenediols

[Term]
id: CHEBI:33575
name: carboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:13428
alt_id: CHEBI:13627
alt_id: CHEBI:23027
def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "acide carboxylique" RELATED [IUPAC]
synonym: "acide carboxylique" RELATED [iupac]
synonym: "acides carboxyliques" RELATED [iupac]
synonym: "acides carboxyliques" RELATED [IUPAC]
synonym: "acido carboxilico" RELATED [iupac]
synonym: "acido carboxilico" RELATED [IUPAC]
synonym: "acidos carboxilicos" RELATED [IUPAC]
synonym: "acidos carboxilicos" RELATED [iupac]
synonym: "Carbonsaeure" RELATED [ChEBI]
synonym: "Carbonsaeure" RELATED [chebi]
synonym: "Carbonsaeuren" RELATED [chebi]
synonym: "Carbonsaeuren" RELATED [ChEBI]
synonym: "Karbonsaeure" RELATED [chebi]
synonym: "Karbonsaeure" RELATED [ChEBI]
synonym: "RC(=O)OH" RELATED [iupac]
synonym: "RC(=O)OH" RELATED [IUPAC]
xref: Wikipedia:Carboxylic_acid
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36586 ! carbonyl compound
is_a: CHEBI:64709 ! organic acid
relationship: BFO:0000051 CHEBI:46883 ! has part carboxy group
relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018034 CHEBI:29067 ! carboxylic acid anion

[Term]
id: CHEBI:33579
name: main group molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." []
subset: 3:STAR
subset: 3_STAR
synonym: "main group compounds" RELATED [chebi]
synonym: "main group compounds" RELATED [ChEBI]
synonym: "main group molecular entities" RELATED [ChEBI]
synonym: "main group molecular entities" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
relationship: BFO:0000051 CHEBI:33318 ! has part main group element atom

[Term]
id: CHEBI:33582
name: carbon group molecular entity
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "carbon group molecular entities" RELATED [chebi]
synonym: "carbon group molecular entities" RELATED [ChEBI]
synonym: "carbon group molecular entity" EXACT [ChEBI]
synonym: "carbon group molecular entity" RELATED [chebi]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: BFO:0000051 CHEBI:33306 ! has part carbon group element atom

[Term]
id: CHEBI:33595
name: cyclic compound
namespace: chebi_ontology
def: "Any molecule that consists of a series of atoms joined together to form a ring." []
subset: 3:STAR
subset: 3_STAR
synonym: "cyclic compounds" RELATED [chebi]
synonym: "cyclic compounds" RELATED [ChEBI]
xref: Wikipedia:Cyclic_compound
is_a: CHEBI:25367 ! molecule

[Term]
id: CHEBI:33597
name: homocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of the same element only." []
subset: 3:STAR
synonym: "isocyclic compounds" RELATED [iupac]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33598
name: carbocyclic compound
namespace: chebi_ontology
def: "A homocyclic compound in which all of the ring members are carbon atoms." []
subset: 3:STAR
synonym: "carbocycle" RELATED [chebi]
is_a: CHEBI:33597 ! homocyclic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33599
name: spiro compound
namespace: chebi_ontology
def: "A compound having one atom as the only common member of two rings." []
subset: 3:STAR
synonym: "spiro-fused compounds" RELATED [iupac]
synonym: "spirocycle" RELATED [chebi]
synonym: "spirocycles" RELATED [chebi]
synonym: "spirocyclic compound" RELATED [chebi]
synonym: "spirocyclic compounds" RELATED [chebi]
synonym: "spirofused compounds" RELATED [chebi]
is_a: CHEBI:33635 ! polycyclic compound

[Term]
id: CHEBI:33608
name: hydrogen molecular entity
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "hydrogen compounds" RELATED [ChEBI]
synonym: "hydrogen compounds" RELATED [chebi]
synonym: "hydrogen molecular entities" RELATED [ChEBI]
synonym: "hydrogen molecular entities" RELATED [chebi]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: BFO:0000051 CHEBI:49637 ! has part hydrogen atom

[Term]
id: CHEBI:33635
name: polycyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "polycyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33636
name: bicyclic compound
namespace: chebi_ontology
def: "A molecule that features two fused rings." []
subset: 3:STAR
synonym: "bicyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33637
name: ortho-fused compound
namespace: chebi_ontology
def: "A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have <em>n</em> common faces and 2<em>n</em> common atoms." []
subset: 3:STAR
synonym: "ortho-fused compounds" RELATED [chebi]
is_a: CHEBI:35293 ! fused compound

[Term]
id: CHEBI:33641
name: olefin
namespace: chebi_ontology
def: "Acyclic and cyclic hydrocarbons having one or more carbon-carbon double bonds, apart from the formal ones in aromatic compounds. The class olefins subsumes alkenes and cycloalkenes and the corresponding polyenes." []
subset: 3:STAR
synonym: "olefins" RELATED [chebi]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:33653
name: aliphatic compound
namespace: chebi_ontology
def: "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." []
subset: 3:STAR
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33655
name: aromatic compound
namespace: chebi_ontology
def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." []
subset: 3:STAR
subset: 3_STAR
synonym: "aromatics" RELATED [chebi]
synonym: "aromatics" RELATED [ChEBI]
synonym: "aromatische Verbindungen" RELATED [ChEBI]
synonym: "aromatische Verbindungen" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33658
name: arene
namespace: chebi_ontology
def: "Any monocyclic or polycyclic aromatic hydrocarbon." []
subset: 3:STAR
synonym: "aromatic hydrocarbons" RELATED [iupac]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33663 ! cyclic hydrocarbon

[Term]
id: CHEBI:33659
name: organic aromatic compound
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "organic aromatic compounds" RELATED [ChEBI]
synonym: "organic aromatic compounds" RELATED [chebi]
is_a: CHEBI:33655 ! aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33661
name: monocyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "monocyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33662
name: annulene
namespace: chebi_ontology
def: "A mancude monocyclic hydrocarbon without side chains of the general formula C<small><sub><em>n</em></sub></small>H<small><sub><em>n</em></sub></small> (<em>n</em> is an even number) or C<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+1</sub></small> (<em>n</em> is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [<em>n</em>]annulene, where <em>n</em> is the number of carbon atoms." []
subset: 3:STAR
is_a: CHEBI:33664 ! monocyclic hydrocarbon

[Term]
id: CHEBI:33663
name: cyclic hydrocarbon
namespace: chebi_ontology
subset: 3:STAR
synonym: "cyclic hydrocarbon" RELATED [chebi]
synonym: "cyclic hydrocarbons" RELATED [chebi]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:33598 ! carbocyclic compound

[Term]
id: CHEBI:33664
name: monocyclic hydrocarbon
namespace: chebi_ontology
subset: 3:STAR
synonym: "monocyclic hydrocarbon" RELATED [chebi]
synonym: "monocyclic hydrocarbons" RELATED [chebi]
is_a: CHEBI:33663 ! cyclic hydrocarbon

[Term]
id: CHEBI:33666
name: polycyclic hydrocarbon
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:33663 ! cyclic hydrocarbon
is_a: CHEBI:35294 ! carbopolycyclic compound

[Term]
id: CHEBI:33670
name: heteromonocyclic compound
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:33661 ! monocyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33671
name: heteropolycyclic compound
namespace: chebi_ontology
def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." []
subset: 3:STAR
synonym: "polyheterocyclic compounds" RELATED [chebi]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33672
name: heterobicyclic compound
namespace: chebi_ontology
def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." []
subset: 3:STAR
is_a: CHEBI:33636 ! bicyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33673
name: zinc group molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "zinc group molecular entities" RELATED [chebi]
is_a: CHEBI:33676 ! d-block molecular entity
relationship: BFO:0000051 CHEBI:33340 ! has part zinc group element atom

[Term]
id: CHEBI:33674
name: s-block molecular entity
namespace: chebi_ontology
def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." []
subset: 3:STAR
subset: 3_STAR
synonym: "s-block compounds" RELATED [chebi]
synonym: "s-block compounds" RELATED [ChEBI]
synonym: "s-block molecular entities" RELATED [chebi]
synonym: "s-block molecular entities" RELATED [ChEBI]
synonym: "s-block molecular entity" EXACT [ChEBI]
synonym: "s-block molecular entity" RELATED [chebi]
is_a: CHEBI:33579 ! main group molecular entity
relationship: BFO:0000051 CHEBI:33559 ! has part s-block element atom

[Term]
id: CHEBI:33675
name: p-block molecular entity
namespace: chebi_ontology
def: "A main group molecular entity that contains one or more atoms of a p-block element." []
subset: 3:STAR
subset: 3_STAR
synonym: "p-block compounds" RELATED [chebi]
synonym: "p-block compounds" RELATED [ChEBI]
synonym: "p-block molecular entities" RELATED [chebi]
synonym: "p-block molecular entities" RELATED [ChEBI]
synonym: "p-block molecular entitiy" RELATED [chebi]
synonym: "p-block molecular entitiy" RELATED [ChEBI]
is_a: CHEBI:33579 ! main group molecular entity
relationship: BFO:0000051 CHEBI:33560 ! has part p-block element atom

[Term]
id: CHEBI:33676
name: d-block molecular entity
namespace: chebi_ontology
def: "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." []
subset: 3:STAR
synonym: "d-block compounds" RELATED [chebi]
synonym: "d-block molecular entities" RELATED [chebi]
synonym: "d-block molecular entity" RELATED [chebi]
is_a: CHEBI:33497 ! transition element molecular entity
relationship: BFO:0000051 CHEBI:33561 ! has part d-block element atom

[Term]
id: CHEBI:33692
name: hydrides
namespace: chebi_ontology
def: "Hydrides are chemical compounds of hydrogen with other chemical elements." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33693
name: oxygen hydride
namespace: chebi_ontology
subset: 3:STAR
synonym: "hydrides of oxygen" RELATED [chebi]
synonym: "oxygen hydride" RELATED [chebi]
synonym: "oxygen hydrides" RELATED [chebi]
is_a: CHEBI:36902 ! chalcogen hydride

[Term]
id: CHEBI:33694
name: biomacromolecule
namespace: chebi_ontology
def: "A macromolecule formed by a living organism." []
subset: 3:STAR
subset: 3_STAR
synonym: "biomacromolecules" RELATED [chebi]
synonym: "biomacromolecules" RELATED [ChEBI]
synonym: "Biopolymere" RELATED [chebi]
synonym: "Biopolymere" RELATED [ChEBI]
synonym: "biopolymers" RELATED [ChEBI]
synonym: "biopolymers" RELATED [chebi]
is_a: CHEBI:33839 ! macromolecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33695
name: information biomacromolecule
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "genetically encoded biomacromolecules" RELATED [ChEBI]
synonym: "genetically encoded biomacromolecules" RELATED [chebi]
synonym: "genetically encoded biopolymers" RELATED [chebi]
synonym: "genetically encoded biopolymers" RELATED [ChEBI]
synonym: "information biomacromolecules" RELATED [ChEBI]
synonym: "information biomacromolecules" RELATED [chebi]
synonym: "information biopolymers" RELATED [chebi]
synonym: "information biopolymers" RELATED [ChEBI]
synonym: "information macromolecule" RELATED [chebi]
synonym: "information macromolecule" RELATED [ChEBI]
synonym: "information macromolecules" RELATED [chebi]
synonym: "information macromolecules" RELATED [ChEBI]
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:33696
name: nucleic acid
namespace: chebi_ontology
def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), <small>D</small>-ribose or 2-deoxy-<small>D</small>-ribose and phosphoric acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "acide nucleique" RELATED [ChEBI]
synonym: "acide nucleique" RELATED [chebi]
synonym: "acides nucleiques" RELATED [ChEBI]
synonym: "acides nucleiques" RELATED [chebi]
synonym: "acido nucleico" RELATED [ChEBI]
synonym: "acido nucleico" RELATED [chebi]
synonym: "acidos nucleicos" RELATED [ChEBI]
synonym: "acidos nucleicos" RELATED [chebi]
synonym: "NA" RELATED [ChEBI]
synonym: "Nukleinsaeure" RELATED [chebi]
synonym: "Nukleinsaeure" RELATED [ChEBI]
synonym: "Nukleinsaeuren" RELATED [ChEBI]
synonym: "Nukleinsaeuren" RELATED [chebi]
is_a: CHEBI:15986 ! polynucleotide
relationship: BFO:0000051 CHEBI:33791 ! has part canonical nucleoside residue
relationship: BFO:0000051 CHEBI:50297 ! has part canonical nucleotide residue

[Term]
id: CHEBI:33697
name: ribonucleic acid
namespace: chebi_ontology
def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." []
subset: 3:STAR
subset: 3_STAR
synonym: "pentosenucleic acids" RELATED [chemidplus]
synonym: "pentosenucleic acids" RELATED [ChemIDplus]
synonym: "ribonucleic acid" EXACT [IUPAC]
synonym: "ribonucleic acid" RELATED [iupac]
synonym: "ribonucleic acids" RELATED [chebi]
synonym: "ribonucleic acids" RELATED [ChEBI]
synonym: "Ribonukleinsaeure" RELATED [chebi]
synonym: "Ribonukleinsaeure" RELATED [ChEBI]
synonym: "ribose nucleic acid" RELATED [ChEBI]
synonym: "ribose nucleic acid" RELATED [chebi]
synonym: "RNA" RELATED [IUPAC, UniProt]
synonym: "RNA" RELATED [iupac, uniprot_ft]
synonym: "RNS" RELATED [chebi]
synonym: "RNS" RELATED [ChEBI]
synonym: "yeast nucleic acid" RELATED [chebi]
synonym: "yeast nucleic acid" RELATED [ChEBI]
is_a: CHEBI:33696 ! nucleic acid
relationship: BFO:0000051 CHEBI:33792 ! has part canonical ribonucleoside residue
relationship: BFO:0000051 CHEBI:50299 ! has part canonical ribonucleotide residue

[Term]
id: CHEBI:33700
name: proteinogenic amino-acid residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "canonical amino-acid residue" RELATED [ChEBI]
synonym: "canonical amino-acid residue" RELATED [chebi]
synonym: "canonical amino-acid residues" RELATED [ChEBI]
synonym: "canonical amino-acid residues" RELATED [chebi]
synonym: "common amino acid residues" RELATED [chebi]
synonym: "common amino acid residues" RELATED [ChEBI]
synonym: "proteinogenic amino-acid residues" RELATED [ChEBI]
synonym: "proteinogenic amino-acid residues" RELATED [chebi]
synonym: "standard amino acid residues" RELATED [ChEBI]
synonym: "standard amino acid residues" RELATED [chebi]
synonym: "standard amino-acid residues" RELATED [chebi]
synonym: "standard amino-acid residues" RELATED [ChEBI]
is_a: CHEBI:33710 ! alpha-amino-acid residue

[Term]
id: CHEBI:33702
name: polyatomic cation
namespace: chebi_ontology
def: "A cation consisting of more than one atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "polyatomic cations" RELATED [chebi]
synonym: "polyatomic cations" RELATED [ChEBI]
is_a: CHEBI:36358 ! polyatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:33703
name: amino-acid cation
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "amino acid cation" RELATED [ChEBI]
synonym: "amino acid cation" RELATED [chebi]
synonym: "amino acid cations" RELATED [ChEBI]
synonym: "amino acid cations" RELATED [chebi]
synonym: "amino-acid cations" RELATED [chebi]
synonym: "amino-acid cations" RELATED [ChEBI]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:33702 ! polyatomic cation
relationship: is_conjugate_acid_of CHEBI:33709 ! amino acid
relationship: RO:0018034 CHEBI:33709 ! amino acid

[Term]
id: CHEBI:33704
name: alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:10208
alt_id: CHEBI:13779
alt_id: CHEBI:22442
alt_id: CHEBI:2642
def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." []
subset: 3:STAR
subset: 3_STAR
synonym: "alpha-amino acids" RELATED [chebi, jcbn]
synonym: "alpha-amino acids" RELATED [ChEBI, JCBN]
synonym: "alpha-amino carboxylic acids" RELATED [iupac]
synonym: "alpha-amino carboxylic acids" RELATED [IUPAC]
synonym: "Amino acid" RELATED [KEGG_COMPOUND]
synonym: "Amino acid" RELATED [kegg.compound]
synonym: "Amino acids" RELATED [kegg.compound]
synonym: "Amino acids" RELATED [KEGG_COMPOUND]
xref: KEGG:C00045
xref: KEGG:C05167
is_a: CHEBI:33709 ! amino acid
relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion
relationship: is_conjugate_base_of CHEBI:33719 ! alpha-amino-acid cation
relationship: is_tautomer_of CHEBI:78608 ! alpha-amino-acid zwitterion
relationship: RO:0018033 CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0018034 CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018036 CHEBI:78608 ! alpha-amino-acid zwitterion

[Term]
id: CHEBI:33708
name: amino-acid residue
namespace: chebi_ontology
def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." []
subset: 3:STAR
subset: 3_STAR
synonym: "amino acid residue" RELATED [ChEBI]
synonym: "amino acid residue" RELATED [chebi]
synonym: "amino acid residues" RELATED [ChEBI]
synonym: "amino acid residues" RELATED [chebi]
synonym: "amino-acid residues" RELATED [JCBN]
synonym: "amino-acid residues" RELATED [jcbn]
is_a: CHEBI:33247 ! organic group
relationship: is_conjugate_acid_of CHEBI:64898 ! anionic amino-acid residue
relationship: is_conjugate_base_of CHEBI:58942 ! cationic amino-acid residue
relationship: is_substituent_group_from CHEBI:33709 ! amino acid
relationship: RO:0018033 CHEBI:58942 ! cationic amino-acid residue
relationship: RO:0018034 CHEBI:64898 ! anionic amino-acid residue
relationship: RO:0018037 CHEBI:33709 ! amino acid

[Term]
id: CHEBI:33709
name: amino acid
namespace: chebi_ontology
alt_id: CHEBI:13815
alt_id: CHEBI:22477
def: "A carboxylic acid containing one or more amino groups." []
subset: 3:STAR
subset: 3_STAR
synonym: "amino acids" RELATED [ChEBI]
synonym: "amino acids" RELATED [chebi]
synonym: "Aminocarbonsaeure" RELATED [ChEBI]
synonym: "Aminocarbonsaeure" RELATED [chebi]
synonym: "Aminokarbonsaeure" RELATED [ChEBI]
synonym: "Aminokarbonsaeure" RELATED [chebi]
synonym: "Aminosaeure" RELATED [ChEBI]
synonym: "Aminosaeure" RELATED [chebi]
xref: Wikipedia:Amino_acid
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:50047 ! organic amino compound
relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:33703 ! amino-acid cation
relationship: RO:0018033 CHEBI:33703 ! amino-acid cation
relationship: RO:0018034 CHEBI:37022 ! amino-acid anion

[Term]
id: CHEBI:3371
name: capreomycin
namespace: chebi_ontology
subset: 2:STAR
synonym: "Capreomycin" RELATED [kegg.compound]
synonym: "capreomycins" RELATED [chebi]
is_a: CHEBI:25903 ! peptide antibiotic

[Term]
id: CHEBI:33710
name: alpha-amino-acid residue
namespace: chebi_ontology
def: "An amino-acid residue derived from an alpha-amino acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "alpha-amino-acid residues" RELATED [chebi]
synonym: "alpha-amino-acid residues" RELATED [ChEBI]
synonym: "an alpha-amino acid residue" RELATED [uniprot_ft]
synonym: "an alpha-amino acid residue" RELATED [UniProt]
is_a: CHEBI:33708 ! amino-acid residue
relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid
relationship: RO:0018037 CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:33719
name: alpha-amino-acid cation
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "alpha-amino acid cation" RELATED [ChEBI]
synonym: "alpha-amino acid cation" RELATED [chebi]
synonym: "alpha-amino acid cations" RELATED [chebi]
synonym: "alpha-amino acid cations" RELATED [ChEBI]
synonym: "alpha-amino-acid cations" RELATED [ChEBI]
synonym: "alpha-amino-acid cations" RELATED [chebi]
is_a: CHEBI:33703 ! amino-acid cation
relationship: is_conjugate_acid_of CHEBI:33704 ! alpha-amino acid
relationship: RO:0018034 CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:33743
name: manganese group molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "manganese group molecular entities" RELATED [chebi]
synonym: "manganese group molecular entity" RELATED [chebi]
is_a: CHEBI:33676 ! d-block molecular entity
relationship: BFO:0000051 CHEBI:33352 ! has part manganese group element atom

[Term]
id: CHEBI:33745
name: copper group molecular entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "copper group molecular entities" RELATED [chebi]
synonym: "copper group molecular entity" RELATED [chebi]
is_a: CHEBI:33676 ! d-block molecular entity
relationship: BFO:0000051 CHEBI:33366 ! has part copper group element atom

[Term]
id: CHEBI:33791
name: canonical nucleoside residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "canonical nucleoside residues" RELATED [chebi]
synonym: "canonical nucleoside residues" RELATED [ChEBI]
synonym: "common nucleoside residues" RELATED [iubmb]
synonym: "common nucleoside residues" RELATED [CBN]
synonym: "nucleoside residue" RELATED [iubmb]
synonym: "nucleoside residue" RELATED [CBN]
synonym: "standard nucleoside residues" RELATED [chebi]
synonym: "standard nucleoside residues" RELATED [ChEBI]
is_a: CHEBI:50320 ! nucleoside residue

[Term]
id: CHEBI:33792
name: canonical ribonucleoside residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "canonical ribonucleoside residues" RELATED [chebi]
synonym: "canonical ribonucleoside residues" RELATED [ChEBI]
synonym: "common ribonucleoside residue" RELATED [iubmb]
synonym: "common ribonucleoside residue" RELATED [CBN]
synonym: "common ribonucleoside residues" RELATED [iubmb]
synonym: "common ribonucleoside residues" RELATED [CBN]
synonym: "N" RELATED [iubmb]
synonym: "N" RELATED [CBN]
synonym: "Nuc" RELATED [iubmb]
synonym: "Nuc" RELATED [CBN]
synonym: "standard ribonucleoside residues" RELATED [chebi]
synonym: "standard ribonucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33791 ! canonical nucleoside residue

[Term]
id: CHEBI:33822
name: organic hydroxy compound
namespace: chebi_ontology
alt_id: CHEBI:64710
def: "An organic compound having at least one hydroxy group attached to a carbon atom." []
subset: 3:STAR
synonym: "organic alcohol" RELATED [chebi]
synonym: "organic hydroxy compounds" RELATED [chebi]
is_a: CHEBI:24651 ! hydroxides
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33832
name: organic cyclic compound
namespace: chebi_ontology
def: "Any organic molecule that consists of atoms connected in the form of a ring." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic cyclic compounds" RELATED [chebi]
synonym: "organic cyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:33833
name: heteroarene
namespace: chebi_ontology
def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." []
subset: 3:STAR
subset: 3_STAR
synonym: "hetarenes" RELATED [iupac]
synonym: "hetarenes" RELATED [IUPAC]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:33836
name: benzenoid aromatic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "benzenoid aromatic compounds" RELATED [chebi]
synonym: "benzenoid compound" RELATED [chebi]
is_a: CHEBI:33598 ! carbocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:33838
name: nucleoside
namespace: chebi_ontology
alt_id: CHEBI:13661
alt_id: CHEBI:25611
alt_id: CHEBI:7647
def: "An <em>N</em>-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." []
subset: 3:STAR
synonym: "a nucleoside" RELATED [uniprot_ft]
synonym: "Nucleoside" RELATED [kegg.compound]
synonym: "nucleosides" RELATED [chebi]
is_a: CHEBI:21731 ! N-glycosyl compound
is_a: CHEBI:26912 ! oxolanes
is_a: CHEBI:61120 ! nucleobase-containing molecular entity

[Term]
id: CHEBI:33839
name: macromolecule
namespace: chebi_ontology
def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
subset: 3:STAR
subset: 3_STAR
synonym: "macromolecules" RELATED [chebi]
synonym: "macromolecules" RELATED [ChEBI]
synonym: "polymer" RELATED [ChEBI]
synonym: "polymer" RELATED [chebi]
synonym: "polymer molecule" RELATED [IUPAC]
synonym: "polymer molecule" RELATED [iupac]
synonym: "polymers" RELATED [chebi]
synonym: "polymers" RELATED [ChEBI]
xref: Wikipedia:Macromolecule
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:33842
name: aromatic annulene
namespace: chebi_ontology
subset: 3:STAR
synonym: "aromatic annulenes" RELATED [chebi]
is_a: CHEBI:33662 ! annulene
is_a: CHEBI:33847 ! monocyclic arene

[Term]
id: CHEBI:33847
name: monocyclic arene
namespace: chebi_ontology
def: "A monocyclic aromatic hydrocarbon." []
subset: 3:STAR
synonym: "monocyclic arenes" RELATED [chebi]
is_a: CHEBI:33658 ! arene

[Term]
id: CHEBI:33848
name: polycyclic arene
namespace: chebi_ontology
def: "A polycyclic aromatic hydrocarbon." []
subset: 3:STAR
synonym: "PAH" RELATED [chebi]
synonym: "PAHs" RELATED [chebi]
synonym: "polycyclic arenes" RELATED [chebi]
synonym: "polycyclic aromatic hydrocarbons" RELATED [chebi]
is_a: CHEBI:33658 ! arene
is_a: CHEBI:33666 ! polycyclic hydrocarbon
relationship: RO:0000087 CHEBI:138015 ! has role endocrine disruptor
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent

[Term]
id: CHEBI:33853
name: phenols
namespace: chebi_ontology
alt_id: CHEBI:13664
alt_id: CHEBI:13825
alt_id: CHEBI:25969
alt_id: CHEBI:2857
alt_id: CHEBI:29322
def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." []
subset: 3:STAR
synonym: "a phenol" RELATED [uniprot_ft]
synonym: "arenols" RELATED [iupac]
synonym: "Aryl alcohol" RELATED [kegg.compound]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:33856
name: aromatic amino acid
namespace: chebi_ontology
alt_id: CHEBI:13820
alt_id: CHEBI:22623
alt_id: CHEBI:2835
def: "An amino acid whose structure includes an aromatic ring." []
subset: 3:STAR
synonym: "Aromatic amino acid" RELATED [kegg.compound]
synonym: "aromatic amino acids" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33709 ! amino acid
relationship: RO:0018034 CHEBI:63473 ! aromatic amino-acid anion
relationship: RO:0018036 CHEBI:76042 ! aromatic amino-acid zwitterion

[Term]
id: CHEBI:33859
name: aromatic carboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:13817
alt_id: CHEBI:13821
alt_id: CHEBI:2830
def: "Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring." []
subset: 3:STAR
synonym: "aromatic carboxylic acids" RELATED [chebi]
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:33659 ! organic aromatic compound
relationship: RO:0018034 CHEBI:91007 ! aromatic carboxylate

[Term]
id: CHEBI:33860
name: aromatic amine
namespace: chebi_ontology
alt_id: CHEBI:13827
alt_id: CHEBI:22622
alt_id: CHEBI:22646
alt_id: CHEBI:2834
alt_id: CHEBI:2863
def: "An amino compound in which the amino group is linked directly to an aromatic system." []
subset: 3:STAR
synonym: "aromatic amines" RELATED [chebi]
synonym: "aryl amine" RELATED [chebi]
synonym: "aryl amines" RELATED [chebi]
synonym: "arylamine" RELATED [chebi]
synonym: "arylamines" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:33861
name: transition element coordination entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "transition element coordination entities" RELATED [chebi]
synonym: "transition metal coordination compounds" RELATED [chebi]
synonym: "transition metal coordination entities" RELATED [chebi]
is_a: CHEBI:33240 ! coordination entity
is_a: CHEBI:33497 ! transition element molecular entity

[Term]
id: CHEBI:33893
name: reagent
namespace: chebi_ontology
def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." []
subset: 3:STAR
subset: 3_STAR
synonym: "reactif" RELATED [IUPAC]
synonym: "reactif" RELATED [iupac]
synonym: "reactivo" RELATED [iupac]
synonym: "reactivo" RELATED [IUPAC]
synonym: "reagents" RELATED [chebi]
synonym: "reagents" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33917
name: aldohexose
namespace: chebi_ontology
alt_id: CHEBI:2558
def: "A hexose with a (potential) aldehyde group at one end." []
subset: 3:STAR
synonym: "aldohexose" RELATED [chebi]
synonym: "aldohexoses" RELATED [chebi]
is_a: CHEBI:15693 ! aldose
is_a: CHEBI:18133 ! hexose

[Term]
id: CHEBI:3392
name: carbendazim
namespace: chebi_ontology
def: "A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls  <em>Ascomycetes</em>, <em>Fungi Imperfecti</em>, and <em>Basidiomycetes</em> on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables." []
subset: 3:STAR
synonym: "1H-benzimidazol-2-ylcarbamic acid methyl ester" RELATED [chebi]
synonym: "2-(Methoxy-carbonylamino)-benzimidazol" RELATED [chemidplus]
synonym: "2-(methoxycarbonylamino)-benzimidazole" RELATED [chemidplus]
synonym: "2-(methoxycarbonylamino)benzimidazole" RELATED [chebi]
synonym: "2-benzimidazolecarbamic acid methyl ester" RELATED [chebi]
synonym: "BMC" RELATED [chebi]
synonym: "Carbendazim" RELATED [kegg.compound]
synonym: "carbendazim" RELATED [uniprot_ft]
synonym: "carbendazime" RELATED [chemidplus]
synonym: "MBC" RELATED [chebi]
synonym: "Mecarzole" RELATED [kegg.compound]
synonym: "methyl 2-benzimidazolecarbamate" RELATED [chemidplus]
synonym: "methyl benzimidazol-2-ylcarbamate" RELATED [chemidplus]
is_a: CHEBI:87036 ! benzimidazole fungicide
is_a: CHEBI:87064 ! benzimidazolylcarbamate fungicide
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug
relationship: RO:0000087 CHEBI:61951 ! has role microtubule-destabilising agent
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018038 CHEBI:27822 ! 2-aminobenzimidazole

[Term]
id: CHEBI:3393
name: carbenicillin
namespace: chebi_ontology
def: "A penicillin antibiotic having a 6β-2-carboxy-2-phenylacetamido side-chain." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "alpha-carboxybenzylpencillin" RELATED [chemidplus]
synonym: "alpha-phenyl(carboxymethylpenicillin)" RELATED [chemidplus]
synonym: "carboxybenzylpenicillin" RELATED [drugbank]
synonym: "CBPC" RELATED [chebi]
synonym: "N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid" RELATED [chemidplus]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:51897 ! carbenicillin(2-)

[Term]
id: CHEBI:33937
name: macronutrient
namespace: chebi_ontology
def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." []
subset: 3:STAR
subset: 3_STAR
synonym: "macronutrients" RELATED [chebi]
synonym: "macronutrients" RELATED [ChEBI]
is_a: CHEBI:33284 ! nutrient

[Term]
id: CHEBI:33958
name: halide salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "halide salts" RELATED [chebi]
synonym: "halides" RELATED [chebi]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:37578 ! halide
relationship: BFO:0000051 CHEBI:16042 ! has part halide anion

[Term]
id: CHEBI:34043
name: 1,2-phenylenediamine
namespace: chebi_ontology
def: "A phenylenediamine in which the two amino groups are <em>ortho</em> to each other." []
subset: 3:STAR
synonym: "1,2-Diaminobenzene" RELATED [kegg.compound]
synonym: "2-Aminoaniline" RELATED [chemidplus]
synonym: "2-Phenylene diamine" RELATED [kegg.compound]
synonym: "o-Phenylenediamine" RELATED [kegg.compound]
synonym: "OPDA" RELATED [chemidplus]
synonym: "phenylene-1,2-dimaine" RELATED [chebi]
is_a: CHEBI:17499 ! hydrogen donor
is_a: CHEBI:51402 ! phenylenediamine
relationship: RO:0018040 CHEBI:16716 ! benzene

[Term]
id: CHEBI:3405
name: carboxin
namespace: chebi_ontology
def: "An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment." []
subset: 3:STAR
synonym: "2,3-Dihydro-5-carboxanilido-6-methyl-1,4-oxathiin" RELATED [chemidplus]
synonym: "2,3-Dihydro-6-methyl-1,4-oxathiin-5-carboxanilide" RELATED [nist]
synonym: "2,3-Dihydro-6-methyl-5-phenylcarbamoyl-1,4-oxathiin" RELATED [chemidplus]
synonym: "5,6-Dihydro-2-methyl-1,4-oxathiin-3-carboxanilide" RELATED [chemidplus]
synonym: "5,6-Dihydro-2-methyl-3-carboxanilido-1,4-oxathiin" RELATED [chemidplus]
synonym: "5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide" RELATED [chemidplus]
synonym: "5-Carboxanilido-2,3-dihydro-6-methyl-1,4-oxathiin" RELATED [chemidplus]
synonym: "Carbathiin" RELATED [chemidplus]
synonym: "Carboxine" RELATED [chemidplus]
synonym: "oxatin" RELATED [metacyc.compound]
is_a: CHEBI:13248 ! anilide
is_a: CHEBI:140325 ! secondary carboxamide
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:38106 ! organosulfur heterocyclic compound
is_a: CHEBI:51751 ! enamide
is_a: CHEBI:87015 ! anilide fungicide
relationship: RO:0000087 CHEBI:83072 ! has role EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:34608
name: captan
namespace: chebi_ontology
def: "A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops." []
subset: 3:STAR
synonym: "1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide" RELATED [chemidplus]
synonym: "3a,4,7,7a-Tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione" RELATED [chemidplus]
synonym: "3a,4,7,7a-tetrahydro-N-(trichloromethanesulphenyl)phthalimide" RELATED [chemidplus]
synonym: "captane" RELATED [chemidplus]
synonym: "ENT 26,538" RELATED [chemidplus]
synonym: "N-(trichloromethylmercapto)-Delta(4)-tetrahydrophthalimide" RELATED [chemidplus]
synonym: "N-[(trichloromethyl)thio]tetrahydrophthalimide" RELATED [chemidplus]
synonym: "N-trichloromethylmercapto-4-cyclohexene-1,2-dicarboximide" RELATED [chemidplus]
synonym: "N-trichloromethylthio-3a,4,7,7a-tetrahydrophthalimide" RELATED [chemidplus]
synonym: "N-trichloromethylthiocyclohex-4-ene-1,2-dicarboximide" RELATED [chemidplus]
synonym: "SR 406" RELATED [chemidplus]
synonym: "SR406" RELATED [chemidplus]
is_a: CHEBI:24897 ! isoindoles
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:87198 ! phthalimide fungicide
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:34653
name: Congo Red
namespace: chebi_ontology
def: "An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0." []
subset: 3:STAR
synonym: "Congo red" RELATED [kegg.compound]
synonym: "Direct red 28" RELATED [kegg.compound]
synonym: "disodium 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(4-aminonaphthalene-1-sulphonate)" RELATED [chemidplus]
synonym: "Kongorot" RELATED [chemidplus]
synonym: "Sodium diphenyldiazo-bis-alpha-naphthylaminesulfonate" RELATED [kegg.compound]
is_a: CHEBI:48960 ! bis(azo) compound
relationship: BFO:0000051 CHEBI:38216 ! has part 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate)
relationship: RO:0018038 CHEBI:38217 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid)

[Term]
id: CHEBI:3478
name: cefaclor
namespace: chebi_ontology
alt_id: CHEBI:472656
def: "A cephalosporin bearing chloro and (<i>R</i>)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton." []
subset: 3:STAR
synonym: "3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid" RELATED [chemidplus]
synonym: "CCL" RELATED [kegg.drug]
synonym: "Cefaclor" RELATED [kegg.compound]
synonym: "cefaclor" RELATED [chembl]
synonym: "Cefaclor anhydrous" RELATED [chemidplus]
synonym: "Cephaclor" RELATED [chemidplus]
is_a: CHEBI:23066 ! cephalosporin
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CHEBI:3499
name: cefotetan
namespace: chebi_ontology
alt_id: CHEBI:558729
def: "A semi-synthetic second-generation cephamycin antibiotic with [(1-methyl-1<em>H</em>-tetrazol-5-yl)sulfanyl]methyl, methoxy and  {[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl}amino groups at the 3, 7α, and 7β positions, respectively, of the cephem skeleton. It is resistant to a wide range of β-lactamases and is active against a broad spectrum of aerobic and anaerobic Gram-positive and Gram-negative microorganisms." []
subset: 3:STAR
synonym: "(6R,7S)-7-(4-(carbamoylcarboxymethylene)-1,3-dithiethane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5- yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylic acid" RELATED [chemidplus]
synonym: "Cefotetan" RELATED [kegg.compound]
synonym: "cefotetan" RELATED [chembl]
is_a: CHEBI:55429 ! cephamycin
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:59358 ! cefotetan(2-)

[Term]
id: CHEBI:34994
name: teicoplanin A2
namespace: chebi_ontology
def: "Any of the glycopeptides whose structure consists of teicoplanin A<small><sub>3</sub></small>-1 in which the hydroxy group of the di(aryloxy)-substituted phenol moiety has been converted to the corresponding 2-acylamino-2-deoxy-β-<small>D</small>-glucoside. Members of the class differ only in the nature of the acyl group." []
subset: 3:STAR
synonym: "teicoplanin A2-*" RELATED [chebi]
is_a: CHEBI:22160 ! acetamides
is_a: CHEBI:24396 ! glycopeptide
is_a: CHEBI:26195 ! polyphenol
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:51026 ! macrocycle
is_a: CHEBI:83403 ! monochlorobenzenes
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0018038 CHEBI:34999 ! teicoplanin A3-1

[Term]
id: CHEBI:34995
name: teicoplanin A2-1
namespace: chebi_ontology
def: "A teicoplanin A<small><sub>2</sub></small> that has (4<i>Z</i>)-dec-4-enoyl as the variable <em>N</em>-acyl group." []
subset: 3:STAR
synonym: "(Z)-34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((1-oxo-4-decenyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chemidplus]
synonym: "(Z)-34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(1-oxo-4-decenyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chebi]
synonym: "Teichomycin A2 factor 1" RELATED [kegg.compound]
synonym: "Teicoplanin A2-1" RELATED [kegg.compound]
is_a: CHEBI:34994 ! teicoplanin A2
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:34996
name: teicoplanin A2-3
namespace: chebi_ontology
def: "A teicoplanin A<small><sub>2</sub></small> that has decanoyl as the variable <em>N</em>-acyl group." []
subset: 3:STAR
synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chemidplus]
synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chebi]
synonym: "Teichomycin A2 factor 3" RELATED [kegg.compound]
synonym: "Teicoplanin A2-3" RELATED [kegg.compound]
is_a: CHEBI:34994 ! teicoplanin A2
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:34997
name: teicoplanin A2-4
namespace: chebi_ontology
def: "A teicoplanin A<small><sub>2</sub></small> that has 8-methyldecanoyl as the variable <em>N</em>-acyl group." []
subset: 3:STAR
synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((8-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chemidplus]
synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(8-methyl-1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chebi]
synonym: "Teichomycin A2 factor 4" RELATED [kegg.compound]
synonym: "Teicoplanin A2-4" RELATED [kegg.compound]
is_a: CHEBI:34994 ! teicoplanin A2
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:34998
name: teicoplanin A2-5
namespace: chebi_ontology
def: "A teicoplanin A<small><sub>2</sub></small> that has 9-methyldecanoyl as the variable <em>N</em>-acyl group." []
subset: 3:STAR
synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((9-methyl-1-oxodecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chemidplus]
synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(9-methyl-1-oxodecyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chebi]
synonym: "Teichomycin A2 factor 5" RELATED [kegg.compound]
synonym: "Teicoplanin A2-5" RELATED [kegg.compound]
is_a: CHEBI:34994 ! teicoplanin A2
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:34999
name: teicoplanin A3-1
namespace: chebi_ontology
def: "A glycopeptide consisting of a macropolycyclic heptapeptide in which a phenolic hydroxy group has been converted to its α-<small>D</small>-mannoside while a secondary alcohol group has been converted to the corresponding 2-acetamido-2-deoxy-β-<small>D</small>-glucoside." []
subset: 3:STAR
synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chemidplus]
synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chebi]
synonym: "Teicoplanin A3-1" RELATED [kegg.compound]
is_a: CHEBI:22160 ! acetamides
is_a: CHEBI:24396 ! glycopeptide
is_a: CHEBI:26191 ! polyol
is_a: CHEBI:26195 ! polyphenol
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:51026 ! macrocycle
is_a: CHEBI:83403 ! monochlorobenzenes
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:35014
name: thiophanate-methyl
namespace: chebi_ontology
def: "A member of the class of thioureas that is the dimethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould." []
subset: 3:STAR
synonym: "1,2-Bis(3-(methoxycarbonyl)-2-thioureido)benzene" RELATED [chemidplus]
synonym: "1,2-Bis(methoxycarbonylthioureido)benzene" RELATED [chemidplus]
synonym: "1,2-Di-(3-methoxycarbonyl-2-thioureido)benzene" RELATED [chemidplus, kegg.compound]
synonym: "dimethyl 4,4'-(o-phenylene)bis(3-thioallophanate)" RELATED [pesticides]
synonym: "dimethyl N,N'-[1,2-phenylenebis(azanediylcarbonothioyl)]dicarbamate" RELATED [pesticides]
synonym: "dimethyl N,N'-[1,2-phenylenebis(iminocarbonothioyl)]bis[carbamate]" RELATED [pesticides]
synonym: "Methyl thiophanate" RELATED [chemidplus]
synonym: "Methylthiofanate" RELATED [chemidplus]
synonym: "Methylthiophanate" RELATED [chemidplus]
synonym: "o-Bis(3-methoxycarbonyl-2-thioureido)benzene" RELATED [chemidplus]
is_a: CHEBI:51276 ! thioureas
is_a: CHEBI:87037 ! benzimidazole precursor fungicide
is_a: CHEBI:87061 ! carbamate fungicide
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:3504
name: cefpodoxime
namespace: chebi_ontology
alt_id: CHEBI:606443
def: "A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis." []
subset: 3:STAR
synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CHEBI:3505
name: cefpodoxime proxetil
namespace: chebi_ontology
def: "The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pharyngitis, and sinusitis." []
subset: 3:STAR
synonym: "(RS)-1-((isopropoxycarbonyl)oxy)ethyl (+)-(6R,7R)-7-(2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate" RELATED [chemidplus]
synonym: "cefpodoxime 1-(isopropyloxycarbonyloxy)ethyl ester" RELATED [chebi]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:33308 ! carboxylic ester
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50266 ! has role prodrug
relationship: RO:0018038 CHEBI:3504 ! cefpodoxime
relationship: RO:0018038 CHEBI:417636 ! 4-{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl}-thiazol-2-yl-ammonium

[Term]
id: CHEBI:3508
name: ceftazidime
namespace: chebi_ontology
def: "A third-generation cephalosporin antibiotic bearing pyridinium-1-ylmethyl and {[(2<i>Z</i>)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton." []
subset: 3:STAR
synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [iupac]
synonym: "CAZ" RELATED [kegg.drug]
synonym: "Ceftazidime anhydrous" RELATED [chemidplus]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:36816 ! oxime O-ether
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50696 ! has role EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
relationship: RO:0018034 CHEBI:53676 ! ceftazidime(1-)

[Term]
id: CHEBI:35106
name: nitrogen hydride
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "nitrogen hydrides" RELATED [ChEBI]
synonym: "nitrogen hydrides" RELATED [chebi]
is_a: CHEBI:35881 ! pnictogen hydride
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35107
name: azane
namespace: chebi_ontology
def: "Saturated acyclic nitrogen hydrides having the general formula N<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+2</sub></small>." []
subset: 3:STAR
subset: 3_STAR
synonym: "azanes" RELATED [ChEBI]
synonym: "azanes" RELATED [chebi]
is_a: CHEBI:35106 ! nitrogen hydride

[Term]
id: CHEBI:35117
name: manganese coordination entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "manganese coordination compounds" RELATED [chebi]
synonym: "manganese coordination entities" RELATED [chebi]
synonym: "manganese coordination entity" RELATED [chebi]
is_a: CHEBI:25154 ! manganese molecular entity
is_a: CHEBI:33861 ! transition element coordination entity

[Term]
id: CHEBI:35131
name: aldose phosphate
namespace: chebi_ontology
subset: 3:STAR
synonym: "aldose phosphates" RELATED [chebi]
is_a: CHEBI:33447 ! phospho sugar

[Term]
id: CHEBI:3515
name: cefuroxime
namespace: chebi_ontology
def: "A 3-(carbamoyloxymethyl)cephalosporin compound having a 7-(2<i>Z</i>)-2-(furan-2-yl)-2-(methoxyimino)acetamido side chain." []
subset: 3:STAR
synonym: "(6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "Cefuroxim" RELATED [chemidplus]
synonym: "Cefuroxime" RELATED [kegg.compound]
synonym: "Cephuroxime" RELATED [chemidplus]
is_a: CHEBI:24129 ! furans
is_a: CHEBI:28084 ! 3-(carbamoyloxymethyl)cephalosporin
is_a: CHEBI:36816 ! oxime O-ether

[Term]
id: CHEBI:35175
name: sulfate salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "sulfate salts" RELATED [chebi]
synonym: "sulfates" RELATED [chebi]
synonym: "sulphate salts" RELATED [chebi]
synonym: "sulphates" RELATED [chebi]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:26820 ! sulfates

[Term]
id: CHEBI:35186
name: terpene
namespace: chebi_ontology
def: "A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH<small><sub>2</sub></small>=C(CH<small><sub>3</sub></small>)CH=CH<small><sub>2</sub></small>]." []
subset: 3:STAR
synonym: "Terpen" RELATED [chebi]
synonym: "terpene" RELATED [iupac]
synonym: "terpenes" RELATED [iupac]
synonym: "terpeno" RELATED [iupac]
synonym: "terpenos" RELATED [iupac]
is_a: CHEBI:24632 ! hydrocarbon
is_a: CHEBI:24913 ! isoprenoid

[Term]
id: CHEBI:35189
name: sesquiterpene
namespace: chebi_ontology
def: "A C<small><sub>15</sub></small> terpene." []
subset: 3:STAR
synonym: "Sesquiterpen" RELATED [chebi]
synonym: "sesquiterpenes" RELATED [iupac]
synonym: "sesquiterpeno" RELATED [iupac]
synonym: "sesquiterpenos" RELATED [iupac]
is_a: CHEBI:35186 ! terpene

[Term]
id: CHEBI:35190
name: diterpene
namespace: chebi_ontology
def: "A C<small><sub>20</sub></small> terpene." []
subset: 3:STAR
synonym: "Diterpen" RELATED [chebi]
synonym: "diterpenes" RELATED [iupac]
synonym: "diterpeno" RELATED [iupac]
synonym: "diterpenos" RELATED [iupac]
is_a: CHEBI:35186 ! terpene

[Term]
id: CHEBI:35195
name: surfactant
namespace: chebi_ontology
def: "A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces." []
subset: 3:STAR
synonym: "surface active agent" RELATED [iupac]
synonym: "surfactants" RELATED [chebi]
is_a: CHEBI:63046 ! emulsifier

[Term]
id: CHEBI:35213
name: cyclodepsipeptide
namespace: chebi_ontology
def: "A depsipeptide in which the amino and hydroxy carboxylic acid residues are connected in a ring." []
subset: 3:STAR
synonym: "Cyclodepsipeptid" RELATED [chebi]
synonym: "Zyklodepsipeptid" RELATED [chebi]
is_a: CHEBI:23643 ! depsipeptide
is_a: CHEBI:25000 ! lactone

[Term]
id: CHEBI:35221
name: antimetabolite
namespace: chebi_ontology
def: "A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." []
subset: 3:STAR
synonym: "antimetabolites" RELATED [chebi]
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:35222
name: inhibitor
namespace: chebi_ontology
def: "A substance that diminishes the rate of a chemical reaction." []
subset: 3:STAR
subset: 3_STAR
synonym: "inhibidor" RELATED [ChEBI]
synonym: "inhibidor" RELATED [chebi]
synonym: "inhibiteur" RELATED [ChEBI]
synonym: "inhibiteur" RELATED [chebi]
synonym: "inhibitors" RELATED [chebi]
synonym: "inhibitors" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:35223
name: catalyst
namespace: chebi_ontology
def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." []
subset: 3:STAR
synonym: "catalizador" RELATED [chebi]
synonym: "catalyseur" RELATED [chebi]
synonym: "Katalysator" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:35238
name: amino-acid zwitterion
namespace: chebi_ontology
def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." []
subset: 3:STAR
subset: 3_STAR
synonym: "amino acid zwitterion" RELATED [ChEBI]
synonym: "amino acid zwitterion" RELATED [chebi]
synonym: "amino acid zwitterions" RELATED [chebi]
synonym: "amino acid zwitterions" RELATED [ChEBI]
synonym: "amino-acid zwitterions" RELATED [chebi]
synonym: "amino-acid zwitterions" RELATED [ChEBI]
is_a: CHEBI:27369 ! zwitterion

[Term]
id: CHEBI:35243
name: serine zwitterion
namespace: chebi_ontology
def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of serine." []
subset: 3:STAR
synonym: "serine zwitterion" RELATED [iupac]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:17822 ! serine

[Term]
id: CHEBI:35267
name: quaternary ammonium ion
namespace: chebi_ontology
alt_id: CHEBI:26470
alt_id: CHEBI:8693
def: "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." []
subset: 3:STAR
synonym: "a quaternary ammonium" RELATED [uniprot_ft]
synonym: "Quaternary amine" RELATED [kegg.compound]
synonym: "quaternary ammonium ions" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative

[Term]
id: CHEBI:35274
name: ammonium ion derivative
namespace: chebi_ontology
def: "A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." []
subset: 3:STAR
synonym: "ammonium ion derivatives" RELATED [chebi]
synonym: "azanium ion derivative" RELATED [chebi]
synonym: "azanium ion derivatives" RELATED [chebi]
is_a: CHEBI:33702 ! polyatomic cation
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: RO:0018040 CHEBI:28938 ! ammonium

[Term]
id: CHEBI:35275
name: S-glycosyl compound
namespace: chebi_ontology
alt_id: CHEBI:22048
alt_id: CHEBI:33577
def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and a S atom bound to a carbon atom, thus creating a C-S bond." []
subset: 3:STAR
synonym: "S-glycoside" RELATED [chebi]
synonym: "S-glycosides" RELATED [chebi]
synonym: "S-glycosyl compound" RELATED [chebi]
synonym: "S-glycosyl compounds" RELATED [chebi]
synonym: "thioglycoside" RELATED [jcbn]
synonym: "thioglycosides" RELATED [jcbn]
is_a: CHEBI:59793 ! monothioacetal
is_a: CHEBI:63161 ! glycosyl compound
is_a: CHEBI:73754 ! thiosugar

[Term]
id: CHEBI:35276
name: ammonium compound
namespace: chebi_ontology
def: "Compounds (NH<small><sub>4</sub></small><small><sup>+</small></sup>)Y<small><sup>−</small></sup> and derivatives, in which one or more of the hydrogens bonded to nitrogen have been replaced with univalent groups." []
subset: 3:STAR
synonym: "ammonium compounds" RELATED [chebi, iupac]
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: BFO:0000051 CHEBI:35274 ! has part ammonium ion derivative

[Term]
id: CHEBI:35281
name: onium betaine
namespace: chebi_ontology
def: "Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." []
subset: 3:STAR
synonym: "onium betaines" RELATED [chebi]
is_a: CHEBI:27369 ! zwitterion

[Term]
id: CHEBI:35285
name: iminium betaine
namespace: chebi_ontology
subset: 3:STAR
synonym: "iminium betaines" RELATED [chebi]
is_a: CHEBI:26469 ! quaternary nitrogen compound
is_a: CHEBI:35281 ! onium betaine

[Term]
id: CHEBI:35286
name: iminium ion
namespace: chebi_ontology
def: "Cations of structure R<small><sub>2</sub></small>C=N<small><sup>+</small></sup>R<small><sub>2</sub></small>." []
subset: 3:STAR
synonym: "iminium cations" RELATED [chebi]
synonym: "iminium ion" RELATED [chebi]
synonym: "iminium ions" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation

[Term]
id: CHEBI:35293
name: fused compound
namespace: chebi_ontology
def: "A polycyclic compound that contains more than one ring with at least two common atoms (also known as bridgehead carbons) that are adjacent to each other." []
subset: 3:STAR
synonym: "fused compounds" RELATED [chebi]
synonym: "fused polycyclic compounds" RELATED [chebi]
synonym: "fused-ring polycyclic compound" RELATED [chebi]
synonym: "fused-ring polycyclic compounds" RELATED [chebi]
synonym: "polycyclic fused-ring compounds" RELATED [chebi]
is_a: CHEBI:33635 ! polycyclic compound

[Term]
id: CHEBI:35294
name: carbopolycyclic compound
namespace: chebi_ontology
def: "A polyclic compound in which all of the ring members are carbon atoms." []
subset: 3:STAR
synonym: "carbopolycyclic compounds" RELATED [chebi]
is_a: CHEBI:33598 ! carbocyclic compound
is_a: CHEBI:35295 ! homopolycyclic compound

[Term]
id: CHEBI:35295
name: homopolycyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "homopolycyclic compounds" RELATED [chebi]
is_a: CHEBI:33597 ! homocyclic compound
is_a: CHEBI:33635 ! polycyclic compound

[Term]
id: CHEBI:35296
name: ortho-fused polycyclic arene
namespace: chebi_ontology
subset: 3:STAR
synonym: "ortho-fused polycyclic arenes" RELATED [chebi]
is_a: CHEBI:33848 ! polycyclic arene
is_a: CHEBI:35427 ! ortho-fused polycyclic hydrocarbon

[Term]
id: CHEBI:35297
name: acene
namespace: chebi_ontology
def: "A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement." []
subset: 3:STAR
synonym: "Acen" RELATED [chebi]
synonym: "acene" RELATED [iupac]
synonym: "Azen" RELATED [chebi]
synonym: "polyacenes" RELATED [chebi]
is_a: CHEBI:35296 ! ortho-fused polycyclic arene
is_a: CHEBI:51269 ! acenes

[Term]
id: CHEBI:35312
name: pentoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "pentoside" RELATED [chebi]
synonym: "pentosides" RELATED [chebi]
is_a: CHEBI:24400 ! glycoside

[Term]
id: CHEBI:35313
name: hexoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "hexoside" RELATED [chebi]
synonym: "hexosides" RELATED [chebi]
is_a: CHEBI:24400 ! glycoside

[Term]
id: CHEBI:3534
name: cephalexin
namespace: chebi_ontology
def: "A semisynthetic first-generation cephalosporin antibiotic having methyl and β-(2<i>R</i>)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract." []
subset: 3:STAR
synonym: "(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid" RELATED [chemidplus]
synonym: "7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid" RELATED [chemidplus]
synonym: "Cefalexin" RELATED [kegg.compound]
synonym: "Celexin" RELATED [chemidplus]
synonym: "Cepastar" RELATED [chemidplus]
synonym: "Cepexin" RELATED [chemidplus]
synonym: "Cephacillin" RELATED [chemidplus]
synonym: "Ceporexin" RELATED [chemidplus]
synonym: "CEX" RELATED [kegg.drug]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:72588 ! semisynthetic derivative
is_a: CHEBI:88225 ! beta-lactam antibiotic allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:59392 ! cephalexin(1-)

[Term]
id: CHEBI:35341
name: steroid
namespace: chebi_ontology
alt_id: CHEBI:13687
alt_id: CHEBI:26768
alt_id: CHEBI:9263
def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[<em>a</em>]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
subset: 3:STAR
synonym: "a steroid" RELATED [uniprot_ft]
synonym: "Steroid" RELATED [kegg.compound]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:51958 ! organic polycyclic compound

[Term]
id: CHEBI:35350
name: hydroxy steroid
namespace: chebi_ontology
alt_id: CHEBI:24748
alt_id: CHEBI:5814
subset: 3:STAR
synonym: "hydroxy steroids" RELATED [chebi]
synonym: "Hydroxysteroid" RELATED [kegg.compound]
synonym: "hydroxysteroids" RELATED [chebi]
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:35341 ! steroid

[Term]
id: CHEBI:35352
name: organonitrogen compound
namespace: chebi_ontology
def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." []
subset: 3:STAR
subset: 3_STAR
synonym: "organonitrogens" RELATED [chebi]
synonym: "organonitrogens" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35356
name: dicarboximide
namespace: chebi_ontology
def: "An imide in which the two acyl substituents on nitrogen are carboacyl groups." []
subset: 3:STAR
synonym: "dicarboximides" RELATED [chebi]
is_a: CHEBI:24782 ! imide

[Term]
id: CHEBI:35358
name: sulfonamide
namespace: chebi_ontology
def: "An amide of a sulfonic acid RS(=O)<small><sub>2</sub></small>NR'<small><sub>2</sub></small>." []
subset: 3:STAR
synonym: "sulfonamides" RELATED [chebi]
is_a: CHEBI:33256 ! primary amide
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:33552 ! sulfonic acid derivative

[Term]
id: CHEBI:35359
name: carboxamidine
namespace: chebi_ontology
def: "Compounds having the structure RC(=NR)NR<small><sub>2</sub></small>. The term is used as a suffix in systematic nomenclature to denote the ‒C(=NH)NH<small><sub>2</sub></small> group including its carbon atom." []
subset: 3:STAR
synonym: "Amidines" RELATED [kegg.compound]
synonym: "carboxamidines" RELATED [chebi]
is_a: CHEBI:2634 ! amidine
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:35362
name: hydrazide
namespace: chebi_ontology
def: "Compounds derived from oxoacids R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) by replacing ‒OH  by ‒NRNR<small><sub>2</sub></small> (R groups are commonly H). (IUPAC)." []
subset: 3:STAR
synonym: "hydrazides" RELATED [chebi]
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35363
name: carbohydrazide
namespace: chebi_ontology
def: "A hydrazide consisting of hydrazine carrying one or more carboacyl groups." []
subset: 3:STAR
synonym: "carbohydrazides" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:35362 ! hydrazide

[Term]
id: CHEBI:35366
name: fatty acid
namespace: chebi_ontology
alt_id: CHEBI:13633
alt_id: CHEBI:24024
alt_id: CHEBI:4984
def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." []
subset: 3:STAR
synonym: "acide gras" RELATED [chebi]
synonym: "acides gras" RELATED [chemidplus]
synonym: "acido graso" RELATED [chebi]
synonym: "acidos grasos" RELATED [chebi]
synonym: "Fatty acid" RELATED [kegg.compound]
synonym: "fatty acids" RELATED [chebi]
synonym: "Fettsaeure" RELATED [chebi]
synonym: "Fettsaeuren" RELATED [chebi]
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0018034 CHEBI:28868 ! fatty acid anion

[Term]
id: CHEBI:35381
name: monosaccharide
namespace: chebi_ontology
alt_id: CHEBI:25407
alt_id: CHEBI:6984
def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
subset: 3:STAR
synonym: "monosacarido" RELATED [chebi]
synonym: "monosacaridos" RELATED [iupac]
synonym: "Monosaccharid" RELATED [chebi]
synonym: "Monosaccharide" RELATED [kegg.compound]
synonym: "Monosacharid" RELATED [chebi]
is_a: CHEBI:16646 ! carbohydrate

[Term]
id: CHEBI:35406
name: oxoanion
namespace: chebi_ontology
alt_id: CHEBI:33274
alt_id: CHEBI:33436
def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." []
subset: 3:STAR
subset: 3_STAR
synonym: "oxoacid anions" RELATED [chebi]
synonym: "oxoacid anions" RELATED [ChEBI]
synonym: "oxoanion" EXACT [ChEBI]
synonym: "oxoanion" RELATED [chebi]
synonym: "oxoanions" RELATED [ChEBI]
synonym: "oxoanions" RELATED [chebi]
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:33273 ! polyatomic anion

[Term]
id: CHEBI:35410
name: primary diamine
namespace: chebi_ontology
alt_id: CHEBI:26264
alt_id: CHEBI:8408
def: "A primary diamine is a compound derived from a hydrocarbon by replacing two hydrogen atoms by amino groups." []
subset: 3:STAR
synonym: "Primary diamine" RELATED [kegg.compound]
synonym: "primary diamines" RELATED [chebi]
is_a: CHEBI:23666 ! diamine

[Term]
id: CHEBI:35411
name: alkane-alpha,omega-diamine
namespace: chebi_ontology
alt_id: CHEBI:10204
alt_id: CHEBI:13775
alt_id: CHEBI:13808
alt_id: CHEBI:22316
alt_id: CHEBI:2577
def: "A primary diamine that is ethane or a higher alkane in which a hydrogen of each of the terminal methyl groups has been replaced by an amino group. H<small><sub>2</sub></small>NCH<small><sub>2</sub></small>(CH<small><sub>2</sub></small>)<small><sub>n</sub></small>CH<small><sub>2</sub></small>NH<small><sub>2</sub></small>, where n = 0, 1, 2, etc." []
subset: 3:STAR
synonym: "Alkane-alpha,omega-diamine" RELATED [kegg.compound]
synonym: "alkane-alpha,omega-diamines" RELATED [chebi]
synonym: "alpha,omega-Diamine" RELATED [kegg.compound]
is_a: CHEBI:35410 ! primary diamine
is_a: CHEBI:46687 ! diazaalkane
relationship: RO:0018033 CHEBI:70977 ! alkane-alpha,omega-diammonium(2+)

[Term]
id: CHEBI:35427
name: ortho-fused polycyclic hydrocarbon
namespace: chebi_ontology
subset: 3:STAR
synonym: "ortho-fused polycyclic hydrocarbon" RELATED [chebi]
synonym: "ortho-fused polycyclic hydrocarbons" RELATED [chebi]
is_a: CHEBI:33637 ! ortho-fused compound

[Term]
id: CHEBI:35436
name: D-glucoside
namespace: chebi_ontology
alt_id: CHEBI:21009
alt_id: CHEBI:4173
def: "Any glucoside in which the glycoside group is derived from <small>D</small>-glucose." []
subset: 3:STAR
synonym: "a D-glucoside" RELATED [uniprot_ft]
synonym: "D-Glucoside" RELATED [kegg.compound]
synonym: "D-glucosides" RELATED [chebi]
is_a: CHEBI:24278 ! glucoside

[Term]
id: CHEBI:35441
name: antiinfective agent
namespace: chebi_ontology
def: "A substance used in the prophylaxis or therapy of infectious diseases." []
subset: 3:STAR
synonym: "anti-infective agents" RELATED [chebi]
synonym: "anti-infective drugs" RELATED [chebi]
synonym: "antiinfective agents" RELATED [chebi]
synonym: "antiinfective drug" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35442
name: antiparasitic agent
namespace: chebi_ontology
def: "A substance used to treat or prevent parasitic infections." []
subset: 3:STAR
synonym: "antiparasitic drugs" RELATED [chebi]
synonym: "antiparasitics" RELATED [chebi]
synonym: "parasiticides" RELATED [chebi]
is_a: CHEBI:35441 ! antiinfective agent

[Term]
id: CHEBI:35443
name: anthelminthic drug
namespace: chebi_ontology
def: "Substance intended to kill parasitic worms (helminths)." []
subset: 3:STAR
synonym: "anthelminthics" RELATED [chebi]
synonym: "anthelmintic" RELATED [iupac]
synonym: "anthelmintics" RELATED [chebi]
synonym: "antihelminth" RELATED [chebi]
synonym: "antihelmintico" RELATED [chebi]
synonym: "vermifuge" RELATED [chebi]
is_a: CHEBI:35442 ! antiparasitic agent

[Term]
id: CHEBI:35444
name: antinematodal drug
namespace: chebi_ontology
def: "A substance used in the treatment or control of nematode infestations." []
subset: 3:STAR
synonym: "antinematodal agent" RELATED [chebi]
synonym: "antinematodal drugs" RELATED [chebi]
synonym: "antinematodals" RELATED [chebi]
is_a: CHEBI:25491 ! nematicide
is_a: CHEBI:35443 ! anthelminthic drug

[Term]
id: CHEBI:35470
name: central nervous system drug
namespace: chebi_ontology
def: "A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system." []
subset: 3:STAR
synonym: "central nervous system agents" RELATED [chebi]
synonym: "CNS agent" RELATED [chebi]
synonym: "CNS drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35472
name: anti-inflammatory drug
namespace: chebi_ontology
def: "A substance that reduces or suppresses inflammation." []
subset: 3:STAR
synonym: "anti-inflammatory drugs" RELATED [chebi]
synonym: "antiinflammatory agent" RELATED [chebi]
synonym: "antiinflammatory drug" RELATED [chebi]
synonym: "antiinflammatory drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:67079 ! anti-inflammatory agent

[Term]
id: CHEBI:35475
name: non-steroidal anti-inflammatory drug
namespace: chebi_ontology
def: "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." []
subset: 3:STAR
synonym: "non-steroidal anti-inflammatory agent" RELATED [chebi]
synonym: "non-steroidal anti-inflammatory drugs" RELATED [chebi]
synonym: "NSAID" RELATED [chebi]
synonym: "NSAIDs" RELATED [chebi]
is_a: CHEBI:35472 ! anti-inflammatory drug
is_a: CHEBI:35842 ! antirheumatic drug

[Term]
id: CHEBI:35479
name: alkali metal salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "alkali metal salts" RELATED [chebi]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33296 ! alkali metal molecular entity

[Term]
id: CHEBI:35488
name: central nervous system depressant
namespace: chebi_ontology
def: "A loosely defined group of drugs that tend to reduce the activity of the central nervous system." []
subset: 3:STAR
synonym: "central nervous system depressants" RELATED [chebi]
synonym: "CNS depressants" RELATED [chebi]
is_a: CHEBI:35470 ! central nervous system drug

[Term]
id: CHEBI:35489
name: organic disulfide
namespace: chebi_ontology
def: "Compounds of structure RSSR in which R and R' are organic groups." []
subset: 3:STAR
synonym: "an organic disulfide" RELATED [uniprot_ft]
synonym: "organic disulfides" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:48343 ! disulfide

[Term]
id: CHEBI:35496
name: fluorobenzenes
namespace: chebi_ontology
def: "Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group." []
subset: 3:STAR
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:37143 ! organofluorine compound

[Term]
id: CHEBI:35497
name: androgen antagonist
namespace: chebi_ontology
def: "A compound which inhibits or antagonises the biosynthesis or actions of androgens." []
subset: 3:STAR
synonym: "antiandrogen" RELATED [chebi]
is_a: CHEBI:49020 ! hormone antagonist

[Term]
id: CHEBI:35498
name: diuretic
namespace: chebi_ontology
def: "An agent that promotes the excretion of urine through its effects on kidney function." []
subset: 3:STAR
synonym: "diuretics" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35507
name: natural product fundamental parent
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:35508
name: steroid fundamental parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "steroid fundamental parents" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:35507 ! natural product fundamental parent

[Term]
id: CHEBI:35515
name: 5alpha-cholestane
namespace: chebi_ontology
alt_id: CHEBI:20650
def: "The 5α-stereoisomer of cholestane." []
subset: 3:STAR
synonym: "(5alpha)-cholestane" RELATED [nist]
synonym: "alpha-cholestane" RELATED [nist]
is_a: CHEBI:35516 ! cholestane

[Term]
id: CHEBI:35516
name: cholestane
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:35508 ! steroid fundamental parent

[Term]
id: CHEBI:35526
name: hypoglycemic agent
namespace: chebi_ontology
def: "A drug which lowers the blood glucose level." []
subset: 3:STAR
synonym: "anti-hyperglycemic agent" RELATED [chebi]
synonym: "anti-hyperglycemic agents" RELATED [chebi]
synonym: "antidiabetic" RELATED [chebi]
synonym: "antihyperglycemic" RELATED [chebi]
synonym: "antihyperglycemic agent" RELATED [chebi]
synonym: "antihyperglycemic agents" RELATED [chebi]
synonym: "antihyperglycemic drug" RELATED [chebi]
synonym: "antihyperglycemic drugs" RELATED [chebi]
synonym: "antihyperglycemics" RELATED [chebi]
synonym: "hypoglycemic agents" RELATED [chebi]
synonym: "hypoglycemic drug" RELATED [chebi]
synonym: "hypoglycemic drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35550
name: 1H-1,2,4-triazole
namespace: chebi_ontology
subset: 3:STAR
synonym: "s-Triazole" RELATED [nist]
is_a: CHEBI:35560 ! 1,2,4-triazole
relationship: RO:0018036 CHEBI:35561 ! 3H-1,2,4-triazole
relationship: RO:0018036 CHEBI:46077 ! 4H-1,2,4-triazole

[Term]
id: CHEBI:35552
name: heterocyclic organic fundamental parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "heterocyclic fundamental parent" RELATED [chebi]
synonym: "heterocyclic organic fundamental parents" RELATED [chebi]
synonym: "organic heterocyclic fundamental parents" RELATED [chebi]
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:35554
name: cardiovascular drug
namespace: chebi_ontology
def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." []
subset: 3:STAR
synonym: "cardiovascular agent" RELATED [chebi]
synonym: "cardiovascular drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35555
name: mancude organic heteromonocyclic parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "mancude organic heteromonocyclic parents" RELATED [chebi]
synonym: "mancude-ring organic heteromonocyclic parents" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:35571 ! mancude organic heterocyclic parent

[Term]
id: CHEBI:35560
name: 1,2,4-triazole
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:38597 ! triazole

[Term]
id: CHEBI:35561
name: 3H-1,2,4-triazole
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:35560 ! 1,2,4-triazole
relationship: RO:0018036 CHEBI:35550 ! 1H-1,2,4-triazole
relationship: RO:0018036 CHEBI:46077 ! 4H-1,2,4-triazole

[Term]
id: CHEBI:35568
name: mancude ring
namespace: chebi_ontology
def: "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." []
subset: 3:STAR
synonym: "mancude rings" RELATED [chebi]
synonym: "mancunide-ring systems" RELATED [iupac]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:35570
name: mancude organic heterobicyclic parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "mancude organic heterobicyclic parents" RELATED [chebi]
synonym: "mancude-ring organic heterobicyclic parents" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:35571 ! mancude organic heterocyclic parent

[Term]
id: CHEBI:35571
name: mancude organic heterocyclic parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "mancude organic heterocyclic parents" RELATED [chebi]
synonym: "mancude-ring organic heterocyclic parents" RELATED [chebi]
is_a: CHEBI:35552 ! heterocyclic organic fundamental parent
is_a: CHEBI:35573 ! organic mancude parent

[Term]
id: CHEBI:35573
name: organic mancude parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic mancude parents" RELATED [chebi]
synonym: "organic mancude-ring parents" RELATED [chebi]
is_a: CHEBI:33245 ! organic fundamental parent
is_a: CHEBI:35568 ! mancude ring

[Term]
id: CHEBI:35604
name: carbon oxoanion
namespace: chebi_ontology
def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>." []
subset: 3:STAR
synonym: "carbon oxoanion" RELATED [chebi]
synonym: "carbon oxoanions" RELATED [chebi]
synonym: "oxocarbon anion" RELATED [chebi]
synonym: "oxocarbon anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35605
name: carbon oxoacid
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "carbon oxoacids" RELATED [chebi]
synonym: "carbon oxoacids" RELATED [ChEBI]
synonym: "oxoacids of carbon" RELATED [chebi]
synonym: "oxoacids of carbon" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35610
name: antineoplastic agent
namespace: chebi_ontology
def: "A substance that inhibits or prevents the proliferation of neoplasms." []
subset: 3:STAR
synonym: "anticancer agent" RELATED [chebi]
synonym: "anticancer agents" RELATED [chebi]
synonym: "antineoplastic" RELATED [chebi]
synonym: "antineoplastic agents" RELATED [chebi]
synonym: "cytostatic" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35618
name: aromatic ether
namespace: chebi_ontology
def: "Any ether in which the oxygen is attached to at least one aryl substituent." []
subset: 3:STAR
is_a: CHEBI:25698 ! ether
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:35620
name: vasodilator agent
namespace: chebi_ontology
def: "A drug used to cause dilation of the blood vessels." []
subset: 3:STAR
synonym: "vasodilator" RELATED [chebi]
synonym: "vasodilator agents" RELATED [chebi]
is_a: CHEBI:35554 ! cardiovascular drug

[Term]
id: CHEBI:35622
name: thiazolidines
namespace: chebi_ontology
subset: 3:STAR
synonym: "thiazolidine" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38106 ! organosulfur heterocyclic compound

[Term]
id: CHEBI:35623
name: anticonvulsant
namespace: chebi_ontology
def: "A drug used to prevent seizures or reduce their severity." []
subset: 3:STAR
synonym: "anti-convulsant" RELATED [chebi]
synonym: "anti-convulsants" RELATED [chebi]
synonym: "anti-convulsive agent" RELATED [chebi]
synonym: "anti-convulsive agents" RELATED [chebi]
synonym: "anticonvulsants" RELATED [chebi]
synonym: "anticonvulsive agent" RELATED [chebi]
synonym: "anticonvulsive agents" RELATED [chebi]
synonym: "antiepileptic" RELATED [chebi]
synonym: "antiepileptics" RELATED [chebi]
synonym: "Antiepileptika" RELATED [chebi]
synonym: "Antiepileptikum" RELATED [chebi]
synonym: "antiepileptique" RELATED [chebi]
synonym: "antiepileptiques" RELATED [chebi]
synonym: "Antikonvulsiva" RELATED [chebi]
synonym: "Antikonvulsivum" RELATED [chebi]
is_a: CHEBI:35488 ! central nervous system depressant

[Term]
id: CHEBI:35625
name: EC 3.5.2.6 (beta-lactamase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of β-lactamase (EC 3.5.2.6)." []
subset: 3:STAR
synonym: "ampicillinase inhibitor" RELATED [chebi]
synonym: "ampicillinase inhibitors" RELATED [chebi]
synonym: "beta-lactam hydrolase inhibitor" RELATED [chebi]
synonym: "beta-lactam hydrolase inhibitors" RELATED [chebi]
synonym: "beta-lactamase (EC 3.5.2.6) inhibitor" RELATED [chebi]
synonym: "beta-lactamase (EC 3.5.2.6) inhibitors" RELATED [chebi]
synonym: "beta-lactamase A, B, C inhibitor" RELATED [chebi]
synonym: "beta-lactamase A, B, C inhibitors" RELATED [chebi]
synonym: "beta-lactamase AME I inhibitor" RELATED [chebi]
synonym: "beta-lactamase AME I inhibitors" RELATED [chebi]
synonym: "beta-lactamase I-III inhibitor" RELATED [chebi]
synonym: "beta-lactamase I-III inhibitors" RELATED [chebi]
synonym: "beta-lactamase inhibitor" RELATED [chebi]
synonym: "beta-lactamase inhibitors" RELATED [chebi]
synonym: "cephalosporin-beta-lactamase inhibitor" RELATED [chebi]
synonym: "cephalosporin-beta-lactamase inhibitors" RELATED [chebi]
synonym: "cephalosporinase inhibitor" RELATED [chebi]
synonym: "cephalosporinase inhibitors" RELATED [chebi]
synonym: "EC 3.5.2.6 (beta-lactamase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.2.6 inhibitor" RELATED [chebi]
synonym: "EC 3.5.2.6 inhibitors" RELATED [chebi]
synonym: "exopenicillinase inhibitor" RELATED [chebi]
synonym: "exopenicillinase inhibitors" RELATED [chebi]
synonym: "neutrapen inhibitor" RELATED [chebi]
synonym: "neutrapen inhibitors" RELATED [chebi]
synonym: "penicillin amido-beta-lactamhydrolase inhibitor" RELATED [chebi]
synonym: "penicillin amido-beta-lactamhydrolase inhibitors" RELATED [chebi]
synonym: "penicillin beta-lactamase inhibitor" RELATED [chebi]
synonym: "penicillin beta-lactamase inhibitors" RELATED [chebi]
synonym: "penicillinase I, II inhibitor" RELATED [chebi]
synonym: "penicillinase I, II inhibitors" RELATED [chebi]
synonym: "penicillinase inhibitor" RELATED [chebi]
synonym: "penicillinase inhibitors" RELATED [chebi]
is_a: CHEBI:76808 ! EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:35627
name: beta-lactam
namespace: chebi_ontology
alt_id: CHEBI:10426
alt_id: CHEBI:13203
alt_id: CHEBI:22845
def: "A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon." []
subset: 3:STAR
synonym: "a beta-lactam" RELATED [uniprot_ft]
synonym: "beta-Lactam" RELATED [kegg.compound]
synonym: "beta-lactams" RELATED [chebi]
is_a: CHEBI:24995 ! lactam

[Term]
id: CHEBI:35674
name: antihypertensive agent
namespace: chebi_ontology
def: "Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism." []
subset: 3:STAR
synonym: "antihypertensive" RELATED [chebi]
synonym: "antihypertensive agents" RELATED [chebi]
synonym: "antihypertensive drug" RELATED [chebi]
synonym: "antihypertensive drugs" RELATED [chebi]
is_a: CHEBI:35554 ! cardiovascular drug

[Term]
id: CHEBI:35679
name: antilipemic drug
namespace: chebi_ontology
def: "A substance used to treat hyperlipidemia (an excess of lipids in the blood)." []
subset: 3:STAR
synonym: "antihyperlipemic" RELATED [chebi]
synonym: "antihyperlipemics" RELATED [chebi]
synonym: "antihyperlipidaemic agent" RELATED [chebi]
synonym: "antihyperlipidaemic agents" RELATED [chebi]
synonym: "antihyperlipidaemic drug" RELATED [chebi]
synonym: "antihyperlipidaemic drugs" RELATED [chebi]
synonym: "antihyperlipidemic" RELATED [chebi]
synonym: "antihyperlipidemic agent" RELATED [chebi]
synonym: "antihyperlipidemic agents" RELATED [chebi]
synonym: "antihyperlipidemic drug" RELATED [chebi]
synonym: "antihyperlipidemic drugs" RELATED [chebi]
synonym: "antihyperlipidemics" RELATED [chebi]
synonym: "antilipemic" RELATED [chebi]
synonym: "antilipemic drugs" RELATED [chebi]
synonym: "antilipemics" RELATED [chebi]
synonym: "hypolipidemic agent" RELATED [chebi]
synonym: "hypolipidemic agents" RELATED [chebi]
synonym: "lipid-lowering agent" RELATED [chebi]
synonym: "lipid-lowering agents" RELATED [chebi]
synonym: "lipid-lowering drug" RELATED [chebi]
synonym: "lipid-lowering drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35681
name: secondary alcohol
namespace: chebi_ontology
alt_id: CHEBI:13425
alt_id: CHEBI:13686
alt_id: CHEBI:16339
alt_id: CHEBI:26617
alt_id: CHEBI:58662
alt_id: CHEBI:8741
alt_id: CHEBI:9077
def: "A secondary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it." []
subset: 3:STAR
synonym: "a secondary alcohol" RELATED [uniprot_ft]
synonym: "R-CHOH-R'" RELATED [kegg.compound]
synonym: "Secondary alcohol" RELATED [kegg.compound]
synonym: "secondary alcohols" RELATED [chebi]
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:35689
name: tetrazoles
namespace: chebi_ontology
def: "An azole in which the five-membered heterocyclic aromatic skeleton contains four N atoms and one C atom." []
subset: 3:STAR
is_a: CHEBI:68452 ! azole

[Term]
id: CHEBI:35692
name: dicarboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:23692
alt_id: CHEBI:36172
alt_id: CHEBI:4501
def: "Any carboxylic acid containing two carboxy groups." []
subset: 3:STAR
synonym: "Dicarboxylic acid" RELATED [kegg.compound]
synonym: "dicarboxylic acids" RELATED [chebi]
is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: CHEBI:35693
name: dicarboxylic acid anion
namespace: chebi_ontology
subset: 3:STAR
synonym: "dicarboxylic acid anion" RELATED [chebi]
synonym: "dicarboxylic acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:35692 ! dicarboxylic acid

[Term]
id: CHEBI:35695
name: dicarboxylic acid monoanion
namespace: chebi_ontology
def: "Any dicarboxylic acid anion that is a monoanion obtained by the deprotonation of only one of the carboxy groups of the dicarboxylic acid." []
subset: 3:STAR
synonym: "dicarboxylic acid monoanions" RELATED [chebi]
is_a: CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: CHEBI:35701
name: ester
namespace: chebi_ontology
alt_id: CHEBI:23960
alt_id: CHEBI:4859
def: "A compound formally derived from an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
subset: 3:STAR
synonym: "Ester" RELATED [kegg.compound]
synonym: "esters" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35703
name: xenobiotic
namespace: chebi_ontology
alt_id: CHEBI:10074
alt_id: CHEBI:27333
def: "A xenobiotic (Greek, <em>xenos</em> \"foreign\"; <em>bios</em> \"life\") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means." []
subset: 3:STAR
synonym: "Xenobiotic" EXACT [KEGG_COMPOUND]
synonym: "Xenobiotic" RELATED [kegg.compound]
synonym: "xenobiotic compounds" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:35705
name: immunosuppressive agent
namespace: chebi_ontology
def: "An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." []
subset: 3:STAR
synonym: "immunosuppressant" RELATED [chebi]
synonym: "immunosuppressive agents" RELATED [chebi]
synonym: "inmunosupresor" RELATED [chebi]
is_a: CHEBI:50846 ! immunomodulator

[Term]
id: CHEBI:35715
name: nitro compound
namespace: chebi_ontology
def: "A compound having a nitro group, ‒NO<small><sub>2</sub></small> (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, <em>C</em>-nitro compounds are usually implied)." []
subset: 3:STAR
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: BFO:0000051 CHEBI:29785 ! has part nitro group

[Term]
id: CHEBI:35716
name: C-nitro compound
namespace: chebi_ontology
def: "A nitro compound having the nitro group (‒NO<small><sub>2</sub></small>) attached to a carbon atom." []
subset: 3:STAR
is_a: CHEBI:35715 ! nitro compound
is_a: CHEBI:72695 ! organic molecule
relationship: RO:0018036 CHEBI:136622 ! aci-nitro compound

[Term]
id: CHEBI:35718
name: antifungal agent
namespace: chebi_ontology
def: "An  antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce." []
subset: 3:STAR
synonym: "antifungal" RELATED [chebi]
synonym: "antifungal agents" RELATED [chebi]
synonym: "antifungal drug" RELATED [chebi]
synonym: "antifungal drugs" RELATED [chebi]
synonym: "antifungals" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:35720
name: enrofloxacin
namespace: chebi_ontology
def: "A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets." []
subset: 3:STAR
synonym: "Baytril" RELATED [chemidplus]
synonym: "Enrofloxacin" RELATED [chemidplus]
is_a: CHEBI:23765 ! quinolone
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:46845 ! N-alkylpiperazine
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:51454 ! cyclopropanes
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent

[Term]
id: CHEBI:35727
name: triazoles
namespace: chebi_ontology
def: "An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms." []
subset: 3:STAR
synonym: "triazole compounds" RELATED [chebi]
is_a: CHEBI:68452 ! azole

[Term]
id: CHEBI:35757
name: monocarboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:13657
alt_id: CHEBI:25382
alt_id: CHEBI:3407
def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." []
subset: 3:STAR
synonym: "a monocarboxylate" RELATED [uniprot_ft]
synonym: "Carboxylate" RELATED [kegg.compound]
synonym: "Monocarboxylate" RELATED [kegg.compound]
synonym: "monocarboxylates" RELATED [chebi]
synonym: "monocarboxylic acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:25384 ! monocarboxylic acid

[Term]
id: CHEBI:35780
name: phosphate ion
namespace: chebi_ontology
def: "A phosphorus oxoanion that is the conjugate base of phosphoric acid." []
subset: 3:STAR
synonym: "phosphate" RELATED [chebi]
synonym: "phosphate ions" RELATED [chebi]
synonym: "Pi" RELATED [chebi]
is_a: CHEBI:33461 ! phosphorus oxoanion
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:26078 ! phosphoric acid

[Term]
id: CHEBI:35785
name: sphingoid
namespace: chebi_ontology
def: "Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds." []
subset: 3:STAR
synonym: "Spd" RELATED [iubmb]
synonym: "sphingoid" RELATED [iubmb]
synonym: "sphingoid base" RELATED [iubmb]
synonym: "sphingoid bases" RELATED [lipidmaps]
synonym: "sphingoids" RELATED [chebi]
is_a: CHEBI:26739 ! sphingolipid
relationship: RO:0018033 CHEBI:83876 ! cationic sphingoid

[Term]
id: CHEBI:35790
name: oxazole
namespace: chebi_ontology
def: "An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom." []
subset: 3:STAR
synonym: "oxazole" RELATED [chebi]
synonym: "oxazoles" RELATED [chebi]
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:68452 ! azole

[Term]
id: CHEBI:35816
name: leprostatic drug
namespace: chebi_ontology
def: "A substance that suppresses <em>Mycobacterium leprae</em>, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions." []
subset: 3:STAR
synonym: "leprostatic" RELATED [chebi]
synonym: "leprostatic agent" RELATED [chebi]
synonym: "leprostatic drugs" RELATED [chebi]
is_a: CHEBI:64912 ! antimycobacterial drug

[Term]
id: CHEBI:35819
name: branched-chain fatty acid
namespace: chebi_ontology
alt_id: CHEBI:22919
alt_id: CHEBI:3166
def: "Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids." []
subset: 3:STAR
synonym: "BCFA" RELATED [chebi]
synonym: "BCFAs" RELATED [chebi]
synonym: "Branched chain fatty acid" RELATED [kegg.compound]
synonym: "branched fatty acid" RELATED [chebi]
synonym: "branched fatty acids" RELATED [chebi]
synonym: "branched-chain fatty acids" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:58955 ! branched-chain fatty acid anion

[Term]
id: CHEBI:35820
name: antiprotozoal drug
namespace: chebi_ontology
def: "Any antimicrobial drug which is used to treat or prevent protozoal infections." []
subset: 3:STAR
synonym: "antiprotozoal agent" RELATED [chebi]
synonym: "antiprotozoal agents" RELATED [chebi]
synonym: "antiprotozoal drugs" RELATED [chebi]
is_a: CHEBI:35442 ! antiparasitic agent
is_a: CHEBI:36043 ! antimicrobial drug

[Term]
id: CHEBI:35842
name: antirheumatic drug
namespace: chebi_ontology
def: "A drug used to treat rheumatoid arthritis." []
subset: 3:STAR
synonym: "anti-rheumatic drugs" RELATED [chebi]
synonym: "antirheumatic agent" RELATED [chebi]
synonym: "antirheumatic drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35850
name: sulfone
namespace: chebi_ontology
def: "An organosulfur compound having the structure RS(=O)<small><sub>2</sub></small>R (R ≠ H)." []
subset: 3:STAR
synonym: "sulfone" RELATED [chebi]
synonym: "sulfones" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:35856
name: lipoxygenase inhibitor
namespace: chebi_ontology
def: "A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes." []
subset: 3:STAR
synonym: "lipooxygenase inhibitor" RELATED [chebi]
synonym: "lipoxygenase inhibitors" RELATED [chebi]
is_a: CHEBI:76837 ! EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor

[Term]
id: CHEBI:35862
name: bacitracin A
namespace: chebi_ontology
def: "A homodetic cyclic peptide consisting of (4<i>R</i>)-2-[(1<i>S</i>,2<i>S</i>)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid attached head-to-tail to <small>L</small>-leucyl,<small>D</small>-glutamyl, <small>L</small>-lysyl, <small>D</small>-ornityl, <small>L</small>-isoleucyl, <small>D</small>-phenylalanyl, <small>L</small>-histidyl. <small>D</small>-aspartyl and <small>L</small>-asparaginyl residues coupled in sequence and cyclised by condensation of the side-chain amino group of the <small>L</small>-lysyl residue with the C-terminal carboxylic acid group. It is the major component of bacitracin." []
subset: 3:STAR
synonym: "Bacitracin A2a" RELATED [chemidplus]
synonym: "Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-l-leucine)-" RELATED [chemidplus]
is_a: CHEBI:15841 ! polypeptide
is_a: CHEBI:24613 ! homodetic cyclic peptide
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent

[Term]
id: CHEBI:35868
name: hydroxy monocarboxylic acid
namespace: chebi_ontology
def: "Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent." []
subset: 3:STAR
synonym: "hydroxy acid" RELATED [chebi]
synonym: "hydroxy monocarboxylic acids" RELATED [chebi]
is_a: CHEBI:24669 ! hydroxy carboxylic acid
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: RO:0018034 CHEBI:36059 ! hydroxy monocarboxylic acid anion

[Term]
id: CHEBI:35871
name: oxo monocarboxylic acid
namespace: chebi_ontology
def: "Any monocarboxylic acid having at least one additional oxo functional group." []
subset: 3:STAR
synonym: "oxo monocarboxylic acids" RELATED [chebi]
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:25754 ! oxo carboxylic acid
relationship: RO:0018034 CHEBI:35902 ! oxo monocarboxylic acid anion

[Term]
id: CHEBI:35875
name: imidazopyrimidine
namespace: chebi_ontology
subset: 3:STAR
synonym: "imidazopyrimidines" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:35881
name: pnictogen hydride
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "pnictogen hydride" EXACT [ChEBI]
synonym: "pnictogen hydride" RELATED [chebi]
synonym: "pnictogen hydrides" RELATED [ChEBI]
synonym: "pnictogen hydrides" RELATED [chebi]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33302 ! pnictogen molecular entity

[Term]
id: CHEBI:35902
name: oxo monocarboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:35178
alt_id: CHEBI:35901
subset: 3:STAR
synonym: "oxo monocarboxylic acid anions" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
is_a: CHEBI:35903 ! oxo carboxylic acid anion
relationship: RO:0018033 CHEBI:35871 ! oxo monocarboxylic acid

[Term]
id: CHEBI:35903
name: oxo carboxylic acid anion
namespace: chebi_ontology
def: "Any carboxylic acid anion containing at least one oxo group." []
subset: 3:STAR
synonym: "oxo carboxylic acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:25754 ! oxo carboxylic acid

[Term]
id: CHEBI:35915
name: sterol ester
namespace: chebi_ontology
alt_id: CHEBI:13220
alt_id: CHEBI:15115
alt_id: CHEBI:18213
alt_id: CHEBI:26770
alt_id: CHEBI:26772
alt_id: CHEBI:9268
alt_id: CHEBI:9269
def: "A steroid ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of a sterol." []
subset: 3:STAR
synonym: "3-hydroxysteroid ester" RELATED [chebi]
synonym: "3-hydroxysteroid esters" RELATED [chebi]
synonym: "a sterol ester" RELATED [uniprot_ft]
synonym: "Sterol ester" RELATED [kegg.compound]
synonym: "Steryl ester" RELATED [kegg.compound]
is_a: CHEBI:33308 ! carboxylic ester
is_a: CHEBI:47880 ! steroid ester

[Term]
id: CHEBI:35942
name: neurotransmitter agent
namespace: chebi_ontology
def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." []
subset: 3:STAR
synonym: "neurotransmitter agents" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:35973
name: 3-oxo monocarboxylic acid anion
namespace: chebi_ontology
def: "An oxo monocarboxylic acid anion having the oxo group located at the 3-position (R = H or organyl group)." []
subset: 3:STAR
synonym: "3-oxo monocarboxylic acid anions" RELATED [chebi]
synonym: "a 3-oxo acid" RELATED [uniprot_ft]
is_a: CHEBI:35902 ! oxo monocarboxylic acid anion
relationship: RO:0018033 CHEBI:47881 ! 3-oxo monocarboxylic acid

[Term]
id: CHEBI:35983
name: 7-oxo monocarboxylic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "7-oxo monocarboxylic acids" RELATED [chebi]
is_a: CHEBI:35871 ! oxo monocarboxylic acid

[Term]
id: CHEBI:35992
name: penams
namespace: chebi_ontology
def: "Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5<i>R</i> configuration unless otherwise specified." []
subset: 3:STAR
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:27933 ! beta-lactam antibiotic
is_a: CHEBI:38106 ! organosulfur heterocyclic compound

[Term]
id: CHEBI:36027
name: stilbenol
namespace: chebi_ontology
def: "Any  stilbenoid with at least one phenolic group." []
subset: 3:STAR
synonym: "stilbenol" RELATED [chebi]
is_a: CHEBI:26776 ! stilbenoid
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:36043
name: antimicrobial drug
namespace: chebi_ontology
def: "A drug used to treat or prevent microbial infections." []
subset: 3:STAR
synonym: "antimicrobial drugs" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent
is_a: CHEBI:35441 ! antiinfective agent

[Term]
id: CHEBI:36047
name: antibacterial drug
namespace: chebi_ontology
def: "A drug used to treat or prevent bacterial infections." []
subset: 3:STAR
synonym: "antibacterial drugs" RELATED [chebi]
is_a: CHEBI:33282 ! antibacterial agent
is_a: CHEBI:36043 ! antimicrobial drug

[Term]
id: CHEBI:36059
name: hydroxy monocarboxylic acid anion
namespace: chebi_ontology
def: "Any monocarboxylic acid anion carrying at least one hydroxy substituent." []
subset: 3:STAR
synonym: "hydroxy monocarboxylic acid anions" RELATED [chebi]
synonym: "hydroxymonocarboxylic acid anion" RELATED [chebi]
synonym: "hydroxymonocarboxylic acid anions" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:35868 ! hydroxy monocarboxylic acid

[Term]
id: CHEBI:36080
name: protein
namespace: chebi_ontology
alt_id: CHEBI:13677
alt_id: CHEBI:14911
def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:33695 ! information biomacromolecule
is_a: PR:000018263 ! amino acid chain
is_a: PR:000064867 ! protein-containing molecular entity
equivalent_to: PR:000000001 ! protein
relationship: BFO:0000051 CHEBI:16541 ! has part protein polypeptide chain

[Term]
id: CHEBI:36093
name: inorganic chloride
namespace: chebi_ontology
subset: 3:STAR
synonym: "inorganic chloride salt" RELATED [chebi]
synonym: "inorganic chloride salts" RELATED [chebi]
synonym: "inorganic chlorides" RELATED [chebi]
is_a: CHEBI:23114 ! chloride salt
is_a: CHEBI:24839 ! inorganic salt

[Term]
id: CHEBI:36141
name: quinone
namespace: chebi_ontology
alt_id: CHEBI:13684
alt_id: CHEBI:26517
def: "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of ‒CH= groups into ‒C(=O)‒ groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." []
subset: 3:STAR
synonym: "Chinon" RELATED [chebi]
synonym: "quinone" RELATED [iupac]
synonym: "quinones" RELATED [chebi]
is_a: CHEBI:3992 ! cyclic ketone

[Term]
id: CHEBI:36233
name: disaccharide
namespace: chebi_ontology
alt_id: CHEBI:23844
alt_id: CHEBI:4654
def: "A compound in which two monosaccharides are joined by a glycosidic bond." []
subset: 3:STAR
synonym: "disacarido" RELATED [chebi]
synonym: "disacaridos" RELATED [iupac]
synonym: "Disaccharid" RELATED [chebi]
synonym: "Disaccharide" RELATED [kegg.compound]
synonym: "Disacharid" RELATED [chebi]
is_a: CHEBI:50699 ! oligosaccharide

[Term]
id: CHEBI:36244
name: dicarboxylic acid monoester
namespace: chebi_ontology
def: "A monoester of a dicarboxylic acid." []
subset: 3:STAR
synonym: "dicarboxylic acid monoesters" RELATED [chebi]
is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:33308 ! carboxylic ester
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0018034 CHEBI:131605 ! dicarboxylic acid monoester(1-)

[Term]
id: CHEBI:36335
name: trypanocidal drug
namespace: chebi_ontology
def: "A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida." []
subset: 3:STAR
synonym: "antitrypanosomal agent" RELATED [chebi]
synonym: "antitrypanosomal agents" RELATED [chebi]
synonym: "antitrypanosomal drug" RELATED [chebi]
synonym: "antitrypanosomal drugs" RELATED [chebi]
synonym: "trypanocidal drugs" RELATED [chebi]
synonym: "trypanocide" RELATED [chebi]
synonym: "trypanosomicidal agents" RELATED [chebi]
is_a: CHEBI:35820 ! antiprotozoal drug

[Term]
id: CHEBI:36336
name: naphthalenesulfonic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "naphthalenesulfonic acids" RELATED [chebi]
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:33555 ! arenesulfonic acid

[Term]
id: CHEBI:36338
name: lepton
namespace: chebi_ontology
def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." []
subset: 3:STAR
subset: 3_STAR
synonym: "leptons" RELATED [chebi]
synonym: "leptons" RELATED [ChEBI]
is_a: CHEBI:33233 ! fundamental particle
is_a: CHEBI:36340 ! fermion

[Term]
id: CHEBI:36339
name: baryon
namespace: chebi_ontology
def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." []
subset: 3:STAR
subset: 3_STAR
synonym: "baryons" RELATED [ChEBI]
synonym: "baryons" RELATED [chebi]
is_a: CHEBI:36340 ! fermion
is_a: CHEBI:36344 ! hadron

[Term]
id: CHEBI:36340
name: fermion
namespace: chebi_ontology
def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." []
subset: 3:STAR
subset: 3_STAR
synonym: "fermions" RELATED [chebi]
synonym: "fermions" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36342
name: subatomic particle
namespace: chebi_ontology
def: "A particle smaller than an atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "subatomic particles" RELATED [ChEBI]
synonym: "subatomic particles" RELATED [chebi]
xref: Wikipedia:Subatomic_particle

[Term]
id: CHEBI:36343
name: composite particle
namespace: chebi_ontology
def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." []
subset: 3:STAR
subset: 3_STAR
synonym: "composite particles" RELATED [ChEBI]
synonym: "composite particles" RELATED [chebi]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36344
name: hadron
namespace: chebi_ontology
def: "Hadron is a subatomic particle which experiences the strong force." []
subset: 3:STAR
subset: 3_STAR
synonym: "hadrons" RELATED [ChEBI]
synonym: "hadrons" RELATED [chebi]
is_a: CHEBI:36343 ! composite particle

[Term]
id: CHEBI:36347
name: nuclear particle
namespace: chebi_ontology
def: "A nucleus or any of its constituents in any of their energy states." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36357
name: polyatomic entity
namespace: chebi_ontology
def: "Any molecular entity consisting of more than one atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "polyatomic entities" RELATED [ChEBI]
synonym: "polyatomic entities" RELATED [chebi]
is_a: CHEBI:23367 ! molecular entity
relationship: BFO:0000051 CHEBI:24433 ! has part group

[Term]
id: CHEBI:36358
name: polyatomic ion
namespace: chebi_ontology
def: "An ion consisting of more than one atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "polyatomic ions" RELATED [chebi]
synonym: "polyatomic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:36359
name: phosphorus oxoacid derivative
namespace: chebi_ontology
subset: 3:STAR
synonym: "phosphorus oxoacid derivative" RELATED [chebi]
is_a: CHEBI:33241 ! oxoacid derivative
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives
relationship: RO:0018038 CHEBI:33457 ! phosphorus oxoacid

[Term]
id: CHEBI:36360
name: phosphorus oxoacids and derivatives
namespace: chebi_ontology
subset: 1:STAR
synonym: "phosphorus oxoacids and derivatives" RELATED [chebi]
is_a: CHEBI:26082 ! phosphorus molecular entity

[Term]
id: CHEBI:36361
name: phosphorous acid
namespace: chebi_ontology
alt_id: CHEBI:26081
alt_id: CHEBI:29196
subset: 3:STAR
synonym: "[P(OH)3]" RELATED [iupac]
synonym: "H3PO3" RELATED [iupac, nist]
synonym: "P(OH)3" RELATED [iupac]
synonym: "phosphite" RELATED [uniprot_ft]
synonym: "phosphorige Saeure" RELATED [chebi]
synonym: "phosphorous acid" RELATED [iupac]
is_a: CHEBI:33457 ! phosphorus oxoacid
relationship: RO:0018034 CHEBI:29258 ! dihydrogenphosphite
relationship: RO:0018036 CHEBI:44976 ! phosphonic acid

[Term]
id: CHEBI:36386
name: dichloroacetic acid
namespace: chebi_ontology
alt_id: CHEBI:23695
alt_id: CHEBI:4502
alt_id: CHEBI:49918
def: "An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, <em>Asparagopsis taxiformis</em>." []
subset: 3:STAR
synonym: "2,2-dichloroacetic acid" RELATED [chemidplus]
synonym: "bichloracetic acid" RELATED [nist]
synonym: "dichloracetic acid" RELATED [nist]
synonym: "Dichloressigsaeure" RELATED [chebi]
synonym: "DICHLORO-ACETIC ACID" RELATED [pdb-ccd]
synonym: "Dichloroacetate" EXACT [KEGG_COMPOUND]
synonym: "Dichloroacetate" RELATED [kegg.compound]
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:36683 ! organochlorine compound
relationship: RO:0000087 CHEBI:74783 ! has role astringent
relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite
relationship: RO:0018034 CHEBI:28240 ! dichloroacetate
relationship: RO:0018038 CHEBI:15366 ! acetic acid

[Term]
id: CHEBI:36388
name: saturated organic heterocyclic parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "saturated heterocyclic parent hydride" RELATED [chebi]
synonym: "saturated heterocyclic parent hydrides" RELATED [chebi]
synonym: "saturated organic heterocyclic parents" RELATED [chebi]
is_a: CHEBI:35552 ! heterocyclic organic fundamental parent

[Term]
id: CHEBI:36389
name: saturated organic heteromonocyclic parent
namespace: chebi_ontology
subset: 3:STAR
synonym: "saturated heteromonocyclic parent hydride" RELATED [chebi]
synonym: "saturated heteromonocyclic parent hydrides" RELATED [chebi]
synonym: "saturated organic heteromonocyclic parents" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:36388 ! saturated organic heterocyclic parent

[Term]
id: CHEBI:3639
name: chlorothalonil
namespace: chebi_ontology
def: "A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops." []
subset: 3:STAR
synonym: "1,3-Dicyanotetrachlorobenzene" RELATED [chemidplus]
synonym: "2,4,5,6-Tetrachloro-3-cyanobenzonitrile" RELATED [chemidplus]
synonym: "Chlorothalonil" RELATED [kegg.compound]
synonym: "chlorothalonil" RELATED [uniprot_ft]
synonym: "m-TCPN" RELATED [chemidplus]
synonym: "m-Tetrachlorophthalonitrile" RELATED [chemidplus]
synonym: "meta-TCPN" RELATED [chemidplus]
synonym: "meta-Tetrachlorophthalodinitrile" RELATED [chemidplus]
synonym: "Tetrachloroisophthalonitrile" RELATED [kegg.compound]
synonym: "TPN" RELATED [kegg.compound]
is_a: CHEBI:26888 ! tetrachlorobenzene
is_a: CHEBI:51308 ! dinitrile
is_a: CHEBI:87034 ! aromatic fungicide
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018038 CHEBI:38218 ! isophthalonitrile

[Term]
id: CHEBI:36563
name: zinc group coordination entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "zinc group coordination compounds" RELATED [chebi]
synonym: "zinc group coordination entities" RELATED [chebi]
is_a: CHEBI:33240 ! coordination entity
is_a: CHEBI:33673 ! zinc group molecular entity

[Term]
id: CHEBI:36566
name: zinc coordination entity
namespace: chebi_ontology
subset: 3:STAR
synonym: "zinc coordination compounds" RELATED [chebi]
synonym: "zinc coordination entities" RELATED [chebi]
is_a: CHEBI:27364 ! zinc molecular entity
is_a: CHEBI:36563 ! zinc group coordination entity

[Term]
id: CHEBI:36586
name: carbonyl compound
namespace: chebi_ontology
def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:36587 ! organic oxo compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: BFO:0000051 CHEBI:23019 ! has part carbonyl group

[Term]
id: CHEBI:36587
name: organic oxo compound
namespace: chebi_ontology
def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic oxo compounds" RELATED [ChEBI]
synonym: "organic oxo compounds" RELATED [chebi]
is_a: CHEBI:72695 ! organic molecule
relationship: BFO:0000051 CHEBI:46629 ! has part oxo group

[Term]
id: CHEBI:36622
name: benzimidazole
namespace: chebi_ontology
def: "A mancude organic heterobicyclic parent that is a heterocyclic organic compound comprising fused benzene and imidazole rings." []
subset: 3:STAR
synonym: "Benzimidazol" RELATED [chebi]
is_a: CHEBI:22715 ! benzimidazoles
is_a: CHEBI:35570 ! mancude organic heterobicyclic parent

[Term]
id: CHEBI:36623
name: 4H-benzimidazole
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:36622 ! benzimidazole
relationship: RO:0018036 CHEBI:36639 ! 2H-benzimidazole
relationship: RO:0018036 CHEBI:36641 ! 3aH-benzimidazole
relationship: RO:0018036 CHEBI:41275 ! 1H-benzimidazole

[Term]
id: CHEBI:36624
name: naphthyridine
namespace: chebi_ontology
def: "Any one of eight organic heterobicyclic compounds that have a naphthalene skeleton in which two of the carbons are replaced by nitrogens. A 'closed' class." []
subset: 3:STAR
is_a: CHEBI:35570 ! mancude organic heterobicyclic parent
is_a: CHEBI:50893 ! azaarene
is_a: CHEBI:52362 ! ortho-fused heteroarene

[Term]
id: CHEBI:36628
name: 1,8-naphthyridine
namespace: chebi_ontology
def: "A naphthyridine in which the nitrogens are situated at positions 1 and 8." []
subset: 3:STAR
synonym: "1,8-diazanaphthalene" RELATED [nist]
synonym: "1,8-pyridopyridine" RELATED [nist]
synonym: "napy" RELATED [iupac]
is_a: CHEBI:36624 ! naphthyridine

[Term]
id: CHEBI:36639
name: 2H-benzimidazole
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:36622 ! benzimidazole
relationship: RO:0018036 CHEBI:36623 ! 4H-benzimidazole
relationship: RO:0018036 CHEBI:36641 ! 3aH-benzimidazole
relationship: RO:0018036 CHEBI:41275 ! 1H-benzimidazole

[Term]
id: CHEBI:36641
name: 3aH-benzimidazole
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:36622 ! benzimidazole
relationship: RO:0018036 CHEBI:36623 ! 4H-benzimidazole
relationship: RO:0018036 CHEBI:36639 ! 2H-benzimidazole
relationship: RO:0018036 CHEBI:41275 ! 1H-benzimidazole

[Term]
id: CHEBI:36683
name: organochlorine compound
namespace: chebi_ontology
def: "An organochlorine compound is a compound containing at least one carbon-chlorine bond." []
subset: 3:STAR
synonym: "an organochlorine molecule" RELATED [uniprot_ft]
synonym: "chloroorganic compounds" RELATED [chebi]
synonym: "chlororganische Verbindungen" RELATED [chebi]
synonym: "organochloride" RELATED [chebi]
synonym: "organochloride compound" RELATED [chebi]
synonym: "organochloride compounds" RELATED [chebi]
synonym: "organochlorides" RELATED [chebi]
synonym: "organochlorine compound" RELATED [chebi]
synonym: "organochlorine compounds" RELATED [chebi]
is_a: CHEBI:17792 ! organohalogen compound
is_a: CHEBI:23117 ! chlorine molecular entity

[Term]
id: CHEBI:36688
name: heterotricyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "heterotricyclic compound" RELATED [chebi]
synonym: "heterotricyclic compounds" RELATED [chebi]
is_a: CHEBI:33671 ! heteropolycyclic compound

[Term]
id: CHEBI:36700
name: phosphocholines
namespace: chebi_ontology
def: "Any compound having phosphocholine as part of its structure." []
subset: 3:STAR
synonym: "choline phosphates" RELATED [chebi]
synonym: "O-phosphocholines" RELATED [chebi]
synonym: "phosphorylcholines" RELATED [chebi]
is_a: CHEBI:23213 ! choline ester
is_a: CHEBI:23217 ! cholines
is_a: CHEBI:25703 ! organic phosphate
is_a: CHEBI:37734 ! phosphoric ester

[Term]
id: CHEBI:36709
name: aminoquinoline
namespace: chebi_ontology
def: "Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups." []
subset: 3:STAR
synonym: "aminoquinoline" RELATED [chebi]
synonym: "aminoquinolines" RELATED [chebi]
is_a: CHEBI:26513 ! quinolines
is_a: CHEBI:33860 ! aromatic amine

[Term]
id: CHEBI:36756
name: farnesane
namespace: chebi_ontology
def: "A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10." []
subset: 3:STAR
synonym: "Farnesan" RELATED [nist]
synonym: "farnesane" RELATED [nist]
is_a: CHEBI:18310 ! alkane
is_a: CHEBI:35189 ! sesquiterpene
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite

[Term]
id: CHEBI:36757
name: farnesane sesquiterpenoid
namespace: chebi_ontology
subset: 3:STAR
synonym: "farnesane sesquiterpenoid" RELATED [chebi]
synonym: "farnesane sesquiterpenoids" RELATED [chebi]
is_a: CHEBI:26658 ! sesquiterpenoid
relationship: RO:0018040 CHEBI:36756 ! farnesane

[Term]
id: CHEBI:36785
name: carbobicyclic compound
namespace: chebi_ontology
def: "A bicyclic compound in which all the ring atoms are carbon." []
subset: 3:STAR
synonym: "carbobicyclic compounds" RELATED [chebi]
is_a: CHEBI:33636 ! bicyclic compound
is_a: CHEBI:35294 ! carbopolycyclic compound

[Term]
id: CHEBI:36816
name: oxime O-ether
namespace: chebi_ontology
def: "<em>O</em>-organyl oximes R<small><sub>2</sub></small>C=NOR' (R' ≠ H)." []
subset: 3:STAR
synonym: "O-substituted oximes" RELATED [chebi]
synonym: "oxime ether" RELATED [chebi]
synonym: "oxime ethers" RELATED [chebi]
synonym: "oxime O-ether" RELATED [iupac]
synonym: "oxime O-ethers" RELATED [chebi]
is_a: CHEBI:25698 ! ether
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:36820
name: ring assembly
namespace: chebi_ontology
def: "Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved." []
subset: 3:STAR
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:36823
name: pseudohalo group
namespace: chebi_ontology
subset: 3:STAR
synonym: "halogenoid group" RELATED [chebi]
synonym: "pseudohalido group" RELATED [chebi]
synonym: "pseudohalo groups" RELATED [chebi]
synonym: "pseudohalogen group" RELATED [iupac]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:36828
name: pseudohalide anion
namespace: chebi_ontology
subset: 3:STAR
synonym: "pseudohalide anions" RELATED [chebi]
synonym: "pseudohalides" RELATED [chebi]
synonym: "pseudohalogen anion" RELATED [chebi]
synonym: "pseudohalogen ion" RELATED [chebi]
is_a: CHEBI:36829 ! polyatomic monoanion

[Term]
id: CHEBI:36829
name: polyatomic monoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "polyatomic monoanions" RELATED [chebi]
is_a: CHEBI:33273 ! polyatomic anion
is_a: CHEBI:36830 ! monoanion

[Term]
id: CHEBI:36830
name: monoanion
namespace: chebi_ontology
subset: 3:STAR
synonym: "monoanions" RELATED [chebi]
is_a: CHEBI:22563 ! anion

[Term]
id: CHEBI:36834
name: 3-hydroxy steroid
namespace: chebi_ontology
def: "Any hydroxy steroid carrying a hydroxy group at position 3." []
subset: 3:STAR
synonym: "3-hydroxy steroids" RELATED [chebi]
is_a: CHEBI:35350 ! hydroxy steroid

[Term]
id: CHEBI:36835
name: 3alpha-hydroxy steroid
namespace: chebi_ontology
alt_id: CHEBI:71194
def: "A 3-hydroxy steroid in which the 3-hydroxy substituent is in the α-position." []
subset: 3:STAR
synonym: "3alpha-hydroxy steroids" RELATED [chebi]
synonym: "3alpha-hydroxysteroid" RELATED [chebi]
synonym: "3alpha-hydroxysteroids" RELATED [chebi]
synonym: "a 3alpha-hydroxysteroid" RELATED [uniprot_ft]
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:36834 ! 3-hydroxy steroid

[Term]
id: CHEBI:36841
name: 11-hydroxy steroid
namespace: chebi_ontology
subset: 3:STAR
synonym: "11-hydroxy steroids" RELATED [chebi]
is_a: CHEBI:35350 ! hydroxy steroid

[Term]
id: CHEBI:36856
name: hydrogen isocyanide
namespace: chebi_ontology
subset: 3:STAR
synonym: "CNH" RELATED [chebi]
synonym: "HN(+)#C(-)" RELATED [iupac]
synonym: "HNC" RELATED [nist]
synonym: "hydrogen isocyanide" RELATED [nist]
synonym: "hydroisocyanic acid" RELATED [chebi]
is_a: CHEBI:33405 ! hydracid
relationship: RO:0018034 CHEBI:17514 ! cyanide
relationship: RO:0018036 CHEBI:18407 ! hydrogen cyanide

[Term]
id: CHEBI:36902
name: chalcogen hydride
namespace: chebi_ontology
subset: 3:STAR
synonym: "chalcogen hydride" RELATED [chebi]
synonym: "chalcogen hydrides" RELATED [chebi]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:36914
name: inorganic ion
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "inorganic ions" RELATED [chebi]
synonym: "inorganic ions" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36915
name: inorganic cation
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "inorganic cations" RELATED [ChEBI]
synonym: "inorganic cations" RELATED [chebi]
is_a: CHEBI:36914 ! inorganic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:36916
name: cation
namespace: chebi_ontology
alt_id: CHEBI:23058
alt_id: CHEBI:3473
def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." []
subset: 3:STAR
subset: 3_STAR
synonym: "Cation" EXACT [KEGG_COMPOUND]
synonym: "Cation" RELATED [kegg.compound]
synonym: "cation" EXACT [ChEBI]
synonym: "cation" RELATED [chebi]
synonym: "cationes" RELATED [chebi]
synonym: "cationes" RELATED [ChEBI]
synonym: "cations" RELATED [ChEBI]
synonym: "cations" RELATED [chebi]
synonym: "Kation" RELATED [chebi]
synonym: "Kation" RELATED [ChEBI]
synonym: "Kationen" RELATED [ChEBI]
synonym: "Kationen" RELATED [chebi]
xref: KEGG:C01373
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36961
name: chalcocarbonic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "chalcocarbonic acid" RELATED [chebi]
synonym: "chalcocarbonic acids" RELATED [chebi]
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:36962
name: organochalcogen compound
namespace: chebi_ontology
def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." []
subset: 3:STAR
subset: 3_STAR
synonym: "organochalcogen compound" EXACT [ChEBI]
synonym: "organochalcogen compound" RELATED [chebi]
synonym: "organochalcogen compounds" RELATED [ChEBI]
synonym: "organochalcogen compounds" RELATED [chebi]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:36963
name: organooxygen compound
namespace: chebi_ontology
def: "An organochalcogen compound containing at least one carbon-oxygen bond." []
subset: 3:STAR
subset: 3_STAR
synonym: "organooxygen compound" EXACT [ChEBI]
synonym: "organooxygen compound" RELATED [chebi]
synonym: "organooxygen compounds" RELATED [ChEBI]
synonym: "organooxygen compounds" RELATED [chebi]
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:36976
name: nucleotide
namespace: chebi_ontology
alt_id: CHEBI:13215
alt_id: CHEBI:13663
alt_id: CHEBI:7656
def: "A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid." []
subset: 3:STAR
synonym: "Nucleotide" RELATED [kegg.compound]
synonym: "nucleotides" RELATED [chebi]
is_a: CHEBI:25608 ! nucleoside phosphate

[Term]
id: CHEBI:36982
name: cyclic purine nucleotide
namespace: chebi_ontology
subset: 3:STAR
synonym: "cyclic purine nucleotides" RELATED [chebi]
is_a: CHEBI:23447 ! cyclic nucleotide
is_a: CHEBI:26395 ! purine nucleotide

[Term]
id: CHEBI:36988
name: 5'-deoxyribonucleoside
namespace: chebi_ontology
subset: 1:STAR
synonym: "5'-deoxyribonucleosides" RELATED [chebi]
is_a: CHEBI:23636 ! deoxyribonucleoside

[Term]
id: CHEBI:37022
name: amino-acid anion
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "amino acid anion" RELATED [ChEBI]
synonym: "amino acid anion" RELATED [chebi]
synonym: "amino acid anions" RELATED [ChEBI]
synonym: "amino acid anions" RELATED [chebi]
synonym: "amino-acid anions" RELATED [ChEBI]
synonym: "amino-acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
is_a: CHEBI:35352 ! organonitrogen compound
relationship: is_conjugate_base_of CHEBI:33709 ! amino acid
relationship: RO:0018033 CHEBI:33709 ! amino acid

[Term]
id: CHEBI:37142
name: organoiodine compound
namespace: chebi_ontology
def: "An organoiodine compound is a compound containing at least one carbon-iodine bond." []
subset: 3:STAR
synonym: "organoiodine compound" RELATED [chebi]
synonym: "organoiodine compounds" RELATED [chebi]
is_a: CHEBI:17792 ! organohalogen compound
is_a: CHEBI:24860 ! iodine molecular entity

[Term]
id: CHEBI:37143
name: organofluorine compound
namespace: chebi_ontology
def: "An organofluorine compound is a compound containing at least one carbon-fluorine bond." []
subset: 3:STAR
synonym: "fluoroorganic compound" RELATED [chebi]
synonym: "fluoroorganic compounds" RELATED [chebi]
synonym: "fluoroorganics" RELATED [chebi]
synonym: "fluororganische Verbindungen" RELATED [chebi]
synonym: "organofluorine compound" RELATED [chebi]
synonym: "organofluorine compounds" RELATED [chebi]
is_a: CHEBI:17792 ! organohalogen compound
is_a: CHEBI:24062 ! fluorine molecular entity

[Term]
id: CHEBI:37153
name: EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:62670
def: "Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16)." []
subset: 3:STAR
synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor" RELATED [chebi]
synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors" RELATED [chebi]
synonym: "Aspergillus awamori acid protein phosphatase inhibitor" RELATED [chebi]
synonym: "Aspergillus awamori acid protein phosphatase inhibitors" RELATED [chebi]
synonym: "BCKDH phosphatase inhibitor" RELATED [chebi]
synonym: "BCKDH phosphatase inhibitors" RELATED [chebi]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor" RELATED [chebi]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors" RELATED [chebi]
synonym: "calcineurin inhibitor" RELATED [chebi]
synonym: "calcineurin inhibitors" RELATED [chebi]
synonym: "casein phosphatase inhibitor" RELATED [chebi]
synonym: "casein phosphatase inhibitors" RELATED [chebi]
synonym: "EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.3.16 inhibitor" RELATED [chebi]
synonym: "EC 3.1.3.16 inhibitors" RELATED [chebi]
synonym: "HMG-CoA reductase phosphatase inhibitor" RELATED [chebi]
synonym: "HMG-CoA reductase phosphatase inhibitors" RELATED [chebi]
synonym: "phosphatase 2A inhibitor" RELATED [chebi]
synonym: "phosphatase 2A inhibitors" RELATED [chebi]
synonym: "phosphatase 2B inhibitor" RELATED [chebi]
synonym: "phosphatase 2B inhibitors" RELATED [chebi]
synonym: "phosphatase C-II inhibitor" RELATED [chebi]
synonym: "phosphatase C-II inhibitors" RELATED [chebi]
synonym: "phosphatase H-II inhibitor" RELATED [chebi]
synonym: "phosphatase H-II inhibitors" RELATED [chebi]
synonym: "phosphatase I inhibitor" RELATED [chebi]
synonym: "phosphatase I inhibitors" RELATED [chebi]
synonym: "phosphatase IB inhibitor" RELATED [chebi]
synonym: "phosphatase IB inhibitors" RELATED [chebi]
synonym: "phosphatase II inhibitor" RELATED [chebi]
synonym: "phosphatase II inhibitors" RELATED [chebi]
synonym: "phosphatase III inhibitor" RELATED [chebi]
synonym: "phosphatase III inhibitors" RELATED [chebi]
synonym: "phosphatase IV inhibitor" RELATED [chebi]
synonym: "phosphatase IV inhibitors" RELATED [chebi]
synonym: "phosphatase SP inhibitor" RELATED [chebi]
synonym: "phosphatase SP inhibitors" RELATED [chebi]
synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitor" RELATED [chebi]
synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitors" RELATED [chebi]
synonym: "phosphoprotein phosphatase inhibitor" RELATED [chebi]
synonym: "phosphoprotein phosphatase inhibitors" RELATED [chebi]
synonym: "phosphoprotein phosphohydrolase inhibitor" RELATED [chebi]
synonym: "phosphoprotein phosphohydrolase inhibitors" RELATED [chebi]
synonym: "phosphopyruvate dehydrogenase phosphatase inhibitor" RELATED [chebi]
synonym: "phosphopyruvate dehydrogenase phosphatase inhibitors" RELATED [chebi]
synonym: "phosphospectrin phosphatase inhibitor" RELATED [chebi]
synonym: "phosphospectrin phosphatase inhibitors" RELATED [chebi]
synonym: "polycation modulated (PCM-) phosphatase inhibitor" RELATED [chebi]
synonym: "polycation modulated (PCM-) phosphatase inhibitors" RELATED [chebi]
synonym: "protein D phosphatase inhibitor" RELATED [chebi]
synonym: "protein D phosphatase inhibitors" RELATED [chebi]
synonym: "protein phosphatase inhibitor" RELATED [chebi]
synonym: "protein phosphatase inhibitors" RELATED [chebi]
synonym: "protein phosphatase-1 inhibitor" RELATED [chebi]
synonym: "protein phosphatase-1 inhibitors" RELATED [chebi]
synonym: "protein phosphatase-2A inhibitor" RELATED [chebi]
synonym: "protein phosphatase-2A inhibitors" RELATED [chebi]
synonym: "protein phosphatase-2B inhibitor" RELATED [chebi]
synonym: "protein phosphatase-2B inhibitors" RELATED [chebi]
synonym: "protein phosphatase-2C inhibitor" RELATED [chebi]
synonym: "protein phosphatase-2C inhibitors" RELATED [chebi]
synonym: "protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors" RELATED [chebi]
synonym: "protein serine/threonine phosphatase inhibitor" RELATED [chebi]
synonym: "protein serine/threonine phosphatase inhibitors" RELATED [chebi]
synonym: "serine/threonine specific protein phosphatase inhibitor" RELATED [chebi]
synonym: "serine/threonine specific protein phosphatase inhibitors" RELATED [chebi]
is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor

[Term]
id: CHEBI:37175
name: organic hydride
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic hydrides" RELATED [chebi]
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37176
name: mononuclear parent hydride
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "mononuclear hydride" RELATED [chebi]
synonym: "mononuclear hydride" RELATED [ChEBI]
synonym: "mononuclear hydrides" RELATED [iupac]
synonym: "mononuclear hydrides" RELATED [IUPAC]
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37206
name: hexol
namespace: chebi_ontology
def: "A polyol that contains 6 hydroxy groups." []
subset: 3:STAR
synonym: "hexols" RELATED [chebi]
is_a: CHEBI:26191 ! polyol

[Term]
id: CHEBI:37246
name: elemental sodium
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:26712 ! sodium molecular entity

[Term]
id: CHEBI:37247
name: elemental potassium
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:26217 ! potassium molecular entity

[Term]
id: CHEBI:3732
name: clarithromycin
namespace: chebi_ontology
alt_id: CHEBI:41676
alt_id: CHEBI:442148
alt_id: CHEBI:670147
def: "The 6-<em>O</em>-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate <em>Helicobacter pylori</em> in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis." []
subset: 3:STAR
synonym: "6-O-methylerythromycin" RELATED [chemidplus]
synonym: "6-O-methylerythromycin A" RELATED [chemidplus]
synonym: "CLA" RELATED [drugbank]
synonym: "CLARITHROMYCIN" RELATED [pdb-ccd]
synonym: "Clarithromycin" RELATED [kegg.compound]
is_a: CHEBI:25105 ! macrolide antibiotic
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant

[Term]
id: CHEBI:37404
name: elemental copper
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:23377 ! copper molecular entity

[Term]
id: CHEBI:37407
name: cyclic ether
namespace: chebi_ontology
alt_id: CHEBI:37406
def: "Any ether in which the oxygen atom forms part of a ring." []
subset: 3:STAR
synonym: "cyclic ether" RELATED [iupac]
synonym: "cyclic ethers" EXACT [ChEBI]
synonym: "cyclic ethers" RELATED [chebi]
synonym: "epoxy compounds" RELATED [chebi]
is_a: CHEBI:25698 ! ether
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:37416
name: EC 2.7.7.6 (RNA polymerase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.7.* (nucleotidyltransferase) inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6)." []
subset: 3:STAR
synonym: "C ribonucleic acid formation factors inhibitor" RELATED [chebi]
synonym: "C ribonucleic acid formation factors inhibitors" RELATED [chebi]
synonym: "C RNA formation factors inhibitor" RELATED [chebi]
synonym: "C RNA formation factors inhibitors" RELATED [chebi]
synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitor" RELATED [chebi]
synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitors" RELATED [chebi]
synonym: "directed RNA polymerase inhibitor" RELATED [chebi]
synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitors" RELATED [chebi]
synonym: "DNA-dependent RNA nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "DNA-dependent RNA nucleotidyltransferase inhibitors" RELATED [chebi]
synonym: "DNA-dependent RNA polymerase inhibitor" RELATED [chebi]
synonym: "DNA-dependent RNA polymerase inhibitors" RELATED [chebi]
synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitors" RELATED [chebi]
synonym: "DNA-directed RNA polymerase inhibitor" RELATED [chebi]
synonym: "DNA-directed RNA polymerase inhibitors" RELATED [chebi]
synonym: "EC 2.7.7.6 (RNA polymerase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.7.6 inhibitor" RELATED [chebi]
synonym: "EC 2.7.7.6 inhibitors" RELATED [chebi]
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [chebi]
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [chebi]
synonym: "ribonucleate nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "ribonucleate nucleotidyltransferase inhibitors" RELATED [chebi]
synonym: "ribonucleate polymerase inhibitor" RELATED [chebi]
synonym: "ribonucleate polymerase inhibitors" RELATED [chebi]
synonym: "ribonucleic acid nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "ribonucleic acid nucleotidyltransferase inhibitors" RELATED [chebi]
synonym: "ribonucleic acid polymerase inhibitor" RELATED [chebi]
synonym: "ribonucleic acid polymerase inhibitors" RELATED [chebi]
synonym: "ribonucleic acid transcriptase inhibitor" RELATED [chebi]
synonym: "ribonucleic acid transcriptase inhibitors" RELATED [chebi]
synonym: "ribonucleic polymerase inhibitor" RELATED [chebi]
synonym: "ribonucleic polymerase inhibitors" RELATED [chebi]
synonym: "ribonucleic transcriptase inhibitor" RELATED [chebi]
synonym: "ribonucleic transcriptase inhibitors" RELATED [chebi]
synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [chebi]
synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [chebi]
synonym: "RNA nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "RNA nucleotidyltransferase inhibitors" RELATED [chebi]
synonym: "RNA polymerase (EC 2.7.7.6) inhibitor" RELATED [chebi]
synonym: "RNA polymerase (EC 2.7.7.6) inhibitors" RELATED [chebi]
synonym: "RNA polymerase I inhibitor" RELATED [chebi]
synonym: "RNA polymerase I inhibitors" RELATED [chebi]
synonym: "RNA polymerase II inhibitor" RELATED [chebi]
synonym: "RNA polymerase II inhibitors" RELATED [chebi]
synonym: "RNA polymerase III inhibitor" RELATED [chebi]
synonym: "RNA polymerase III inhibitors" RELATED [chebi]
synonym: "RNA polymerase inhibitor" RELATED [chebi]
synonym: "RNA polymerase inhibitors" RELATED [chebi]
synonym: "RNA transcriptase inhibitor" RELATED [chebi]
synonym: "RNA transcriptase inhibitors" RELATED [chebi]
synonym: "transcriptase inhibitor" RELATED [chebi]
synonym: "transcriptase inhibitors" RELATED [chebi]
is_a: CHEBI:76815 ! EC 2.7.7.* (nucleotidyltransferase) inhibitor

[Term]
id: CHEBI:3745
name: clindamycin
namespace: chebi_ontology
alt_id: CHEBI:47331
def: "A carbohydrate-containing antibiotic that is the  semisynthetic derivative of lincomycin, a natural antibiotic." []
subset: 3:STAR
synonym: "7(S)-Chloro-7-deoxylincomycin" RELATED [chemidplus]
synonym: "7-CDL" RELATED [chemidplus]
synonym: "Cleocin (TN)" RELATED [kegg.drug]
synonym: "Clindamycin" RELATED [kegg.compound]
synonym: "Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside" RELATED [chemidplus]
is_a: CHEBI:23007 ! carbohydrate-containing antibiotic
is_a: CHEBI:35275 ! S-glycosyl compound
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:46770 ! pyrrolidinecarboxamide
is_a: CHEBI:72588 ! semisynthetic derivative
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0018038 CHEBI:6472 ! lincomycin

[Term]
id: CHEBI:3749
name: clofazimine
namespace: chebi_ontology
alt_id: CHEBI:355347
def: "3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of  multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients." []
subset: 3:STAR
synonym: "(4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine" RELATED [chembl]
synonym: "3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine" RELATED [chemidplus]
synonym: "3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin" RELATED [chemidplus]
synonym: "N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine" RELATED [chembl]
is_a: CHEBI:39201 ! phenazines
is_a: CHEBI:83403 ! monochlorobenzenes
relationship: RO:0000087 CHEBI:35475 ! has role non-steroidal anti-inflammatory drug
relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug
relationship: RO:0000087 CHEBI:37958 ! has role dye

[Term]
id: CHEBI:37527
name: acid
namespace: chebi_ontology
alt_id: CHEBI:13800
alt_id: CHEBI:13801
alt_id: CHEBI:22209
alt_id: CHEBI:2426
def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." []
subset: 3:STAR
subset: 3_STAR
synonym: "Acid" EXACT [KEGG_COMPOUND]
synonym: "Acid" RELATED [kegg.compound]
synonym: "acide" RELATED [iupac]
synonym: "acide" RELATED [IUPAC]
synonym: "acido" RELATED [chebi]
synonym: "acido" RELATED [ChEBI]
synonym: "acids" RELATED [chebi]
synonym: "acids" RELATED [ChEBI]
synonym: "Saeure" RELATED [ChEBI]
synonym: "Saeure" RELATED [chebi]
synonym: "Saeuren" RELATED [chebi]
synonym: "Saeuren" RELATED [ChEBI]
xref: KEGG:C00174
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:37533
name: azo compound
namespace: chebi_ontology
def: "Derivatives of diazene with the general structure R‒N=N‒R'." []
subset: 3:STAR
synonym: "azo compounds" RELATED [chebi]
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: BFO:0000051 CHEBI:30106 ! has part azo group
relationship: RO:0018040 CHEBI:30096 ! diazene

[Term]
id: CHEBI:37577
name: heteroatomic molecular entity
namespace: chebi_ontology
def: "A molecular entity consisting of two or more chemical elements." []
subset: 3:STAR
subset: 3_STAR
synonym: "chemical compound" RELATED [ChEBI]
synonym: "chemical compound" RELATED [chebi]
synonym: "heteroatomic molecular entities" RELATED [ChEBI]
synonym: "heteroatomic molecular entities" RELATED [chebi]
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:37578
name: halide
namespace: chebi_ontology
def: "Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements." []
subset: 3:STAR
synonym: "halides" RELATED [chebi]
is_a: CHEBI:24471 ! halogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:37622
name: carboxamide
namespace: chebi_ontology
alt_id: CHEBI:35354
alt_id: CHEBI:35355
def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." []
subset: 3:STAR
subset: 3_STAR
synonym: "carboxamides" RELATED [chebi]
synonym: "carboxamides" RELATED [ChEBI]
synonym: "primary carboxamide" RELATED [ChEBI]
synonym: "primary carboxamide" RELATED [chebi]
is_a: CHEBI:33256 ! primary amide
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: BFO:0000051 CHEBI:23004 ! has part carbamoyl group

[Term]
id: CHEBI:37624
name: L-glucose
namespace: chebi_ontology
subset: 3:STAR
synonym: "L(-)-glucose" RELATED [chemidplus]
is_a: CHEBI:17234 ! glucose

[Term]
id: CHEBI:37627
name: L-glucopyranose
namespace: chebi_ontology
def: "The <small>L</small>-enantiomer of glucopyranose." []
subset: 3:STAR
synonym: "L-glucopyranose" RELATED [uniprot_ft]
is_a: CHEBI:37624 ! L-glucose
is_a: CHEBI:37661 ! glucopyranose

[Term]
id: CHEBI:37630
name: alpha-L-glucose
namespace: chebi_ontology
def: "A <small>L</small>-glucopyranose with an α-configuration at the anomeric position." []
subset: 3:STAR
is_a: CHEBI:37627 ! L-glucopyranose
relationship: RO:0018039 CHEBI:17925 ! alpha-D-glucose

[Term]
id: CHEBI:37661
name: glucopyranose
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:17234 ! glucose

[Term]
id: CHEBI:37670
name: protease inhibitor
namespace: chebi_ontology
def: "A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases)." []
subset: 3:STAR
synonym: "protease inhibitors" RELATED [chebi]
is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor

[Term]
id: CHEBI:37699
name: protein kinase inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (<em>P</em>-containing group transferase) inhibitor that interferes with the action of protein kinases." []
subset: 3:STAR
synonym: "protein kinase inhibitors" RELATED [chebi]
is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor

[Term]
id: CHEBI:37734
name: phosphoric ester
namespace: chebi_ontology
alt_id: CHEBI:26019
subset: 1:STAR
synonym: "phosphate esters" RELATED [chebi]
synonym: "phosphoric esters" RELATED [chebi]
is_a: CHEBI:26079 ! phosphoric acid derivative
is_a: CHEBI:35701 ! ester

[Term]
id: CHEBI:37806
name: penicillanic acid
namespace: chebi_ontology
def: "A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2<i>S</i>,5<i>R</i>)-configuration." []
subset: 3:STAR
synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "penicillanic acid" RELATED [chemidplus]
is_a: CHEBI:25865 ! penicillanic acids

[Term]
id: CHEBI:37826
name: sulfuric acid derivative
namespace: chebi_ontology
subset: 3:STAR
synonym: "sulfuric acid derivative" RELATED [chebi]
synonym: "sulfuric acid derivatives" RELATED [chebi]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
relationship: RO:0018038 CHEBI:26836 ! sulfuric acid

[Term]
id: CHEBI:37838
name: carboacyl group
namespace: chebi_ontology
def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." []
subset: 3:STAR
subset: 3_STAR
synonym: "carboxylic acyl groups" RELATED [iupac]
synonym: "carboxylic acyl groups" RELATED [IUPAC]
is_a: CHEBI:22221 ! acyl group
relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid
relationship: RO:0018037 CHEBI:33575 ! carboxylic acid

[Term]
id: CHEBI:37848
name: plant hormone
namespace: chebi_ontology
alt_id: CHEBI:26158
def: "A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds." []
subset: 3:STAR
synonym: "phytohormone" RELATED [chebi]
synonym: "phytohormones" RELATED [chebi]
synonym: "plant growth factor" RELATED [chebi]
synonym: "plant growth factors" RELATED [chebi]
synonym: "plant growth hormone" RELATED [chebi]
synonym: "plant growth hormones" RELATED [chebi]
synonym: "plant hormones" RELATED [chebi]
is_a: CHEBI:24621 ! hormone
is_a: CHEBI:26155 ! plant growth regulator

[Term]
id: CHEBI:37852
name: organoammonium sulfate salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "organoammonium sulfates" RELATED [chebi]
is_a: CHEBI:46850 ! organoammonium salt
is_a: CHEBI:51337 ! organic sulfate salt

[Term]
id: CHEBI:37912
name: hydroxycoumarin
namespace: chebi_ontology
alt_id: CHEBI:24691
alt_id: CHEBI:24692
def: "Any coumarin carrying at least one hydroxy substituent." []
subset: 3:STAR
synonym: "hydroxycoumarins" RELATED [chebi]
is_a: CHEBI:23403 ! coumarins

[Term]
id: CHEBI:37943
name: colistin
namespace: chebi_ontology
alt_id: CHEBI:34651
alt_id: CHEBI:472593
alt_id: CHEBI:560465
alt_id: CHEBI:566816
alt_id: CHEBI:596826
alt_id: CHEBI:597111
alt_id: CHEBI:600596
alt_id: CHEBI:659853
def: "A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of <em>Bacillus polymyxa</em> var. <em>colistinus</em>. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the <em>N</em>-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to <em>Pseudomonas aeruginosa</em>." []
subset: 3:STAR
synonym: "Colistin" RELATED [chembl]
synonym: "polymyxin E" RELATED [chemidplus]
is_a: CHEBI:25903 ! peptide antibiotic
is_a: CHEBI:59062 ! polymyxin
relationship: BFO:0000051 CHEBI:59064 ! has part colistin A
relationship: BFO:0000051 CHEBI:59673 ! has part colistin B
relationship: RO:0000087 CHEBI:50909 ! has role nephrotoxic agent

[Term]
id: CHEBI:37948
name: oxaspiro compound
namespace: chebi_ontology
def: "A spiro compound in which at least one of the cyclic components is an oxygen heterocyle." []
subset: 3:STAR
synonym: "oxaspiro compounds" RELATED [chebi]
is_a: CHEBI:33599 ! spiro compound

[Term]
id: CHEBI:37958
name: dye
namespace: chebi_ontology
subset: 3:STAR
synonym: "colorante" RELATED [chebi]
synonym: "colorantes" RELATED [chebi]
synonym: "dyes" RELATED [chebi]
synonym: "Farbstoff" RELATED [chebi]
synonym: "Farbstoffe" RELATED [chebi]
synonym: "teinture" RELATED [chebi]
synonym: "teintures" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:38012
name: aminoglycoside sulfate salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "aminoglycoside sulfate salts" RELATED [chebi]
is_a: CHEBI:37852 ! organoammonium sulfate salt

[Term]
id: CHEBI:38032
name: carbotricyclic compound
namespace: chebi_ontology
def: "A carbopolyclic compound comprising of three carbocyclic rings." []
subset: 3:STAR
synonym: "carbotricyclic compounds" RELATED [chebi]
is_a: CHEBI:35294 ! carbopolycyclic compound
is_a: CHEBI:51959 ! organic tricyclic compound

[Term]
id: CHEBI:38068
name: antimalarial
namespace: chebi_ontology
def: "A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against <em>Plasmodia</em> at different stages in their life cycle in the human." []
subset: 3:STAR
synonym: "antimalarials" RELATED [chebi]
is_a: CHEBI:64915 ! antiplasmodial drug

[Term]
id: CHEBI:38070
name: anti-arrhythmia drug
namespace: chebi_ontology
def: "A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres." []
subset: 3:STAR
synonym: "anti-arrhythmia agent" RELATED [chebi]
synonym: "antiarrhythmic agent" RELATED [chebi]
is_a: CHEBI:35554 ! cardiovascular drug

[Term]
id: CHEBI:38099
name: thiadiazoles
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound

[Term]
id: CHEBI:38101
name: organonitrogen heterocyclic compound
namespace: chebi_ontology
def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." []
subset: 3:STAR
subset: 3_STAR
synonym: "heterocyclic organonitrogen compounds" RELATED [chebi]
synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI]
synonym: "organonitrogen heterocyclic compounds" RELATED [chebi]
synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:38102
name: triazines
namespace: chebi_ontology
def: "Compounds based on a triazine skeleton." []
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:50893 ! azaarene

[Term]
id: CHEBI:38104
name: oxacycle
namespace: chebi_ontology
def: "Any organic heterocyclic compound containing at least one ring oxygen atom." []
subset: 3:STAR
synonym: "heterocyclic organooxygen compounds" RELATED [chebi]
synonym: "organooxygen heterocyclic compounds" RELATED [chebi]
synonym: "oxacycles" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:38106
name: organosulfur heterocyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "heterocyclic organosulfur compounds" RELATED [chebi]
synonym: "organosulfur heterocyclic compounds" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:38119
name: brassinin
namespace: chebi_ontology
subset: 3:STAR
synonym: "Brassinine" RELATED [chemidplus]
synonym: "methyl (1H-indol-3-ylmethyl)dithiocarbamate" RELATED [iupac]
is_a: CHEBI:24797 ! indole phytoalexin
is_a: CHEBI:38129 ! dithiocarbamic ester

[Term]
id: CHEBI:38127
name: thiocarbamic ester
namespace: chebi_ontology
def: "Any organonitrogen compound with formula RS-C(=X)NH<small><sub>2</sub></small> where X = O (monothiocarbamic esters) or S (dithiocarbamic esters), or their <em>N</em>-substituted derivatives." []
subset: 3:STAR
synonym: "thiocarbamate" RELATED [chebi]
synonym: "thiocarbamates" RELATED [chebi]
synonym: "thiocarbamic ester" RELATED [chebi]
is_a: CHEBI:26959 ! thiocarboxylic ester
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:38129
name: dithiocarbamic ester
namespace: chebi_ontology
def: "Any ester derived from a member of the class of dithiocarbamic acids by formal replacement of the -SH group by -SR, where R is an organyl group." []
subset: 3:STAR
synonym: "carbamodithioates" RELATED [chebi]
synonym: "carbamodithioic esters" RELATED [chebi]
synonym: "dithiocarbamic ester" RELATED [chebi]
synonym: "dithiocarbamoates" RELATED [chebi]
is_a: CHEBI:38127 ! thiocarbamic ester

[Term]
id: CHEBI:38131
name: lactol
namespace: chebi_ontology
def: "Cyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues." []
subset: 3:STAR
synonym: "lactol" RELATED [iupac]
synonym: "lactols" RELATED [chebi]
is_a: CHEBI:5653 ! hemiacetal

[Term]
id: CHEBI:38161
name: chelator
namespace: chebi_ontology
alt_id: CHEBI:23090
alt_id: CHEBI:3585
alt_id: CHEBI:6789
def: "A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate." []
subset: 3:STAR
synonym: "Chelating agent" RELATED [kegg.compound]
synonym: "chelating agents" RELATED [chebi]
synonym: "chelators" RELATED [chebi]
synonym: "complexon" RELATED [chebi]
synonym: "Metal chelator" RELATED [kegg.compound]
is_a: CHEBI:52214 ! ligand

[Term]
id: CHEBI:38163
name: organic heterotetracyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic heterotetracyclic compounds" RELATED [chebi]
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:38164
name: organic heteropentacyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic heteropentacyclic compounds" RELATED [chebi]
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:38166
name: organic heteropolycyclic compound
namespace: chebi_ontology
alt_id: CHEBI:25429
alt_id: CHEBI:38075
subset: 3:STAR
synonym: "organic heteropolycyclic compounds" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33671 ! heteropolycyclic compound

[Term]
id: CHEBI:38179
name: monocyclic heteroarene
namespace: chebi_ontology
subset: 3:STAR
synonym: "monocyclic heteroarenes" RELATED [chebi]
is_a: CHEBI:33833 ! heteroarene

[Term]
id: CHEBI:38180
name: polycyclic heteroarene
namespace: chebi_ontology
subset: 3:STAR
synonym: "polycyclic heteroarenes" RELATED [chebi]
is_a: CHEBI:33833 ! heteroarene

[Term]
id: CHEBI:38181
name: pyridinemonocarboxylate
namespace: chebi_ontology
def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of a pyridinemonocarboxylic acid. A 'closed class'." []
subset: 3:STAR
synonym: "pyridinemonocarboxylates" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:26420 ! pyridinemonocarboxylic acid

[Term]
id: CHEBI:38186
name: isonicotinate
namespace: chebi_ontology
def: "A pyridinemonocarboxylate resulting from the deprotonation of the carboxy group of isonicotinic acid." []
subset: 3:STAR
synonym: "4-picolinate" RELATED [metacyc.compound]
synonym: "4-pyridinecarboxylate" RELATED [metacyc.compound]
synonym: "gamma-picolinate" RELATED [metacyc.compound]
synonym: "isonicotinate" RELATED [uniprot_ft]
is_a: CHEBI:38181 ! pyridinemonocarboxylate
relationship: RO:0018033 CHEBI:6032 ! isonicotinic acid

[Term]
id: CHEBI:38215
name: calcium channel blocker
namespace: chebi_ontology
def: "One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools." []
subset: 3:STAR
synonym: "calcium channel antagonist" RELATED [chebi]
synonym: "calcium channel antagonists" RELATED [chebi]
synonym: "calcium channel blockers" RELATED [chebi]
is_a: CHEBI:38808 ! calcium channel modulator
is_a: CHEBI:48706 ! antagonist

[Term]
id: CHEBI:38216
name: 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate)
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:25471 ! naphthalenemonosulfonate
relationship: RO:0018033 CHEBI:38217 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid)

[Term]
id: CHEBI:38217
name: 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonic acid)
namespace: chebi_ontology
alt_id: CHEBI:291121
subset: 3:STAR
synonym: "congo red" RELATED [chembl]
is_a: CHEBI:36336 ! naphthalenesulfonic acid
relationship: RO:0018034 CHEBI:38216 ! 3,3'-(biphenyl-4,4'-diyldidiazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate)

[Term]
id: CHEBI:38218
name: isophthalonitrile
namespace: chebi_ontology
subset: 3:STAR
synonym: "1,3-Benzenedicarbonitrile" RELATED [nist]
synonym: "1,3-Dicyanobenzene" RELATED [chemidplus]
synonym: "3-Cyanobenzonitrile" RELATED [chemidplus]
synonym: "IPN" RELATED [nist]
synonym: "Isophthalodinitrile" RELATED [nist]
synonym: "m-Dicyanobenzene" RELATED [chemidplus]
is_a: CHEBI:18379 ! nitrile
relationship: RO:0018038 CHEBI:30802 ! isophthalic acid

[Term]
id: CHEBI:38231
name: phytotoxin
namespace: chebi_ontology
def: "Any toxin produced by a plant." []
subset: 3:STAR
synonym: "phytotoxins" RELATED [chebi]
is_a: CHEBI:27026 ! toxin
is_a: CHEBI:76924 ! plant metabolite

[Term]
id: CHEBI:38260
name: pyrrolidines
namespace: chebi_ontology
alt_id: CHEBI:26922
alt_id: CHEBI:38191
def: "Any of a class of heterocyclic amines having a saturated five-membered ring." []
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38261
name: imidazolidines
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:38304 ! diazolidine

[Term]
id: CHEBI:38295
name: azabicycloalkane
namespace: chebi_ontology
subset: 3:STAR
synonym: "azabicycloalkanes" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38298
name: benzodioxoles
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:38304
name: diazolidine
namespace: chebi_ontology
subset: 3:STAR
synonym: "diazolidines" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38311
name: cephem
namespace: chebi_ontology
subset: 3:STAR
synonym: "cephems" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:27933 ! beta-lactam antibiotic
is_a: CHEBI:38106 ! organosulfur heterocyclic compound

[Term]
id: CHEBI:38313
name: diazines
namespace: chebi_ontology
def: "Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure)." []
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38314
name: pyrazines
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:38313 ! diazines

[Term]
id: CHEBI:38329
name: oxazolidines
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:38337
name: pyrimidone
namespace: chebi_ontology
def: "A pyrimidine carrying one or more oxo substituents." []
subset: 3:STAR
synonym: "pyrimidones" RELATED [chebi]
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:38338
name: aminopyrimidine
namespace: chebi_ontology
def: "A member of the class of  pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives." []
subset: 3:STAR
synonym: "aminopyrimidines" RELATED [chebi]
is_a: CHEBI:33860 ! aromatic amine
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:38418
name: 1,3-thiazoles
namespace: chebi_ontology
alt_id: CHEBI:26949
alt_id: CHEBI:38417
subset: 3:STAR
synonym: "1,3-thiazoles" RELATED [chebi]
is_a: CHEBI:48901 ! thiazoles

[Term]
id: CHEBI:38443
name: 1-benzopyran
namespace: chebi_ontology
subset: 3:STAR
synonym: "1-benzopyrans" RELATED [chebi]
is_a: CHEBI:22727 ! benzopyran

[Term]
id: CHEBI:38445
name: chromenone
namespace: chebi_ontology
subset: 3:STAR
synonym: "chromenones" RELATED [chebi]
is_a: CHEBI:23232 ! chromenes

[Term]
id: CHEBI:38496
name: electron-transport chain inhibitor
namespace: chebi_ontology
subset: 1:STAR
synonym: "electron transport chain inhibitors" RELATED [chebi]
synonym: "ETC inhibitor" RELATED [chebi]
is_a: CHEBI:76932 ! pathway inhibitor

[Term]
id: CHEBI:38497
name: respiratory-chain inhibitor
namespace: chebi_ontology
subset: 1:STAR
synonym: "respiratory chain inhibitor" RELATED [chebi]
synonym: "respiratory electron-transport chain inhibitor" RELATED [chebi]
synonym: "respiratory-chain inhibitors" RELATED [chebi]
is_a: CHEBI:38496 ! electron-transport chain inhibitor

[Term]
id: CHEBI:38498
name: mitochondrial NADH:ubiquinone reductase inhibitor
namespace: chebi_ontology
subset: 3:STAR
synonym: "mitochondrial complex I inhibitor" RELATED [chebi]
synonym: "mitochondrial complex I inhibitors" RELATED [chebi]
synonym: "mitochondrial NADH dehydrogenase inhibitor" RELATED [chebi]
is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor
is_a: CHEBI:38503 ! EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor

[Term]
id: CHEBI:38499
name: mitochondrial cytochrome-bc1 complex inhibitor
namespace: chebi_ontology
subset: 3:STAR
synonym: "mitochondrial complex III inhibitor" RELATED [chebi]
synonym: "mitochondrial complex III inhibitors" RELATED [chebi]
is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor
is_a: CHEBI:38502 ! cytochrome-bc1 complex inhibitor

[Term]
id: CHEBI:38500
name: EC 1.9.3.1 (cytochrome c oxidase) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:38501
alt_id: CHEBI:62966
def: "An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome <em>c</em> oxidase (EC 1.9.3.1)." []
subset: 3:STAR
synonym: "CcO inhibitor" RELATED [chebi]
synonym: "complex IV (mitochondrial electron transport) inhibitor" RELATED [chebi]
synonym: "complex IV (mitochondrial electron transport) inhibitors" RELATED [chebi]
synonym: "cytochrome a3 inhibitor" RELATED [chebi]
synonym: "cytochrome a3 inhibitors" RELATED [chebi]
synonym: "cytochrome aa3 inhibitor" RELATED [chebi]
synonym: "cytochrome aa3 inhibitors" RELATED [chebi]
synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitor" RELATED [chebi]
synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitors" RELATED [chebi]
synonym: "cytochrome c oxidase inhibitor" RELATED [chebi]
synonym: "cytochrome c oxidase inhibitors" RELATED [chebi]
synonym: "cytochrome oxidase inhibitor" RELATED [chebi]
synonym: "cytochrome oxidase inhibitors" RELATED [chebi]
synonym: "cytochrome-c oxidase inhibitor" RELATED [chebi]
synonym: "cytochrome-c oxidase inhibitors" RELATED [chebi]
synonym: "EC 1.9.3.1 (cytochrome c oxidase) inhibitors" RELATED [chebi]
synonym: "EC 1.9.3.1 inhibitor" RELATED [chebi]
synonym: "EC 1.9.3.1 inhibitors" RELATED [chebi]
synonym: "ferrocytochrome c oxidase inhibitor" RELATED [chebi]
synonym: "ferrocytochrome c oxidase inhibitors" RELATED [chebi]
synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitor" RELATED [chebi]
synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitors" RELATED [chebi]
synonym: "indophenol oxidase inhibitor" RELATED [chebi]
synonym: "indophenol oxidase inhibitors" RELATED [chebi]
synonym: "indophenolase inhibitor" RELATED [chebi]
synonym: "indophenolase inhibitors" RELATED [chebi]
synonym: "mitochondrial complex IV inhibitor" RELATED [chebi]
synonym: "mitochondrial complex IV inhibitors" RELATED [chebi]
synonym: "mitochondrial cytochrome-c oxidase inhibitors" RELATED [chebi]
synonym: "NADH cytochrome c oxidase inhibitor" RELATED [chebi]
synonym: "NADH cytochrome c oxidase inhibitors" RELATED [chebi]
synonym: "Warburg's respiratory enzyme inhibitor" RELATED [chebi]
synonym: "Warburg's respiratory enzyme inhibitors" RELATED [chebi]
is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor
is_a: CHEBI:76870 ! EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor

[Term]
id: CHEBI:38502
name: cytochrome-bc1 complex inhibitor
namespace: chebi_ontology
subset: 1:STAR
synonym: "cytochrome-bc1 complex inhibitors" RELATED [chebi]
synonym: "cytochrome-bc1 inhibitor" RELATED [chebi]
is_a: CHEBI:38497 ! respiratory-chain inhibitor

[Term]
id: CHEBI:38503
name: EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor
namespace: chebi_ontology
def: "A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (H<small><sup>+</small></sup>-translocating), EC 1.6.5.3." []
subset: 3:STAR
synonym: "coenzyme Q reductase" RELATED [chebi]
synonym: "complex 1 dehydrogenase inhibitor" RELATED [chebi]
synonym: "complex I (electron transport chain) inhibitors" RELATED [chebi]
synonym: "complex I (mitochondrial electron transport) inhibitors" RELATED [chebi]
synonym: "complex I (NADH:Q1 oxidoreductase) inhibitors" RELATED [chebi]
synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor" RELATED [chebi]
synonym: "DPNH-coenzyme Q reductase inhibitor" RELATED [chebi]
synonym: "DPNH-ubiquinone reductase inhibitor" RELATED [chebi]
synonym: "EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitor" RELATED [chebi]
synonym: "EC 1.6.5.3 (NADH:ubiquinone reductase (H(+)-translocating)) inhibitors" RELATED [chebi]
synonym: "EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitors" RELATED [chebi]
synonym: "EC 1.6.5.3 inhibitor" RELATED [chebi]
synonym: "EC 1.6.5.3 inhibitors" RELATED [chebi]
synonym: "electron transfer complex I inhibitor" RELATED [chebi]
synonym: "electron transfer complex I inhibitors" RELATED [chebi]
synonym: "mitochondrial electron transport complex 1 inhibitor" RELATED [chebi]
synonym: "mitochondrial electron transport complex I inhibitor" RELATED [chebi]
synonym: "mitochondrial electron transport complex I inhibitors" RELATED [chebi]
synonym: "NADH coenzyme Q1 reductase inhibitor" RELATED [chebi]
synonym: "NADH coenzyme Q1 reductase inhibitors" RELATED [chebi]
synonym: "NADH dehydrogenase (ubiquinone) inhibitor" RELATED [chebi]
synonym: "NADH dehydrogenase (ubiquinone) inhibitors" RELATED [chebi]
synonym: "NADH-coenzyme Q oxidoreductase inhibitors" RELATED [chebi]
synonym: "NADH-coenzyme Q reductase inhibitor" RELATED [chebi]
synonym: "NADH-coenzyme Q reductase inhibitors" RELATED [chebi]
synonym: "NADH-CoQ oxidoreductase inhibitor" RELATED [chebi]
synonym: "NADH-CoQ oxidoreductase inhibitors" RELATED [chebi]
synonym: "NADH-CoQ reductase inhibitor" RELATED [chebi]
synonym: "NADH-CoQ reductase inhibitors" RELATED [chebi]
synonym: "NADH-Q6 oxidoreductase inhibitor" RELATED [chebi]
synonym: "NADH-ubiquinone oxidoreductase inhibitor" RELATED [chebi]
synonym: "NADH-ubiquinone oxidoreductase inhibitors" RELATED [chebi]
synonym: "NADH-ubiquinone reductase inhibitor" RELATED [chebi]
synonym: "NADH-ubiquinone reductase inhibitors" RELATED [chebi]
synonym: "NADH-ubiquinone-1 reductase inhibitor" RELATED [chebi]
synonym: "NADH-ubiquinone-1 reductase inhibitors" RELATED [chebi]
synonym: "NADH2 dehydrogenase (ubiquinone) inhibitor" RELATED [chebi]
synonym: "NADH:ubiquinone oxidoreductase complex inhibitor" RELATED [chebi]
synonym: "NADH:ubiquinone oxidoreductase inhibitor" RELATED [chebi]
synonym: "NADH:ubiquinone oxidoreductase inhibitors" RELATED [chebi]
synonym: "NADH:ubiquinone reductase (H(+)-translocating) inhibitor" RELATED [chebi]
synonym: "NADH:ubiquinone reductase (H(+)-translocating) inhibitors" RELATED [chebi]
synonym: "NADH:ubiquinone reductase (H+-translocating) inhibitor" RELATED [chebi]
synonym: "NADH:ubiquinone reductase inhibitor" RELATED [chebi]
synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor" RELATED [chebi]
synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase inhibitors" RELATED [chebi]
synonym: "type 1 dehydrogenase inhibitor" RELATED [chebi]
synonym: "type 1 dehydrogenase inhibitors" RELATED [chebi]
synonym: "ubiquinone reductase inhibitor" RELATED [chebi]
synonym: "ubiquinone reductase inhibitors" RELATED [chebi]
is_a: CHEBI:38497 ! respiratory-chain inhibitor
is_a: CHEBI:76866 ! EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor

[Term]
id: CHEBI:38532
name: hydrazone
namespace: chebi_ontology
def: "Compounds having the structure R<small><sub>2</sub></small>C=NNR<small><sub>2</sub></small>, formally derived from aldehydes or ketones by replacing =O by =NNH<small><sub>2</sub></small> (or substituted analogues)." []
subset: 3:STAR
synonym: "hydrazones" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:38582
name: difluorobenzene
namespace: chebi_ontology
def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying two fluorine atoms." []
subset: 3:STAR
synonym: "Difluorbenzol" RELATED [chebi]
synonym: "difluorobenzenes" RELATED [chebi]
is_a: CHEBI:35496 ! fluorobenzenes

[Term]
id: CHEBI:38584
name: 1,3-difluorobenzene
namespace: chebi_ontology
def: "A difluorobenzene carrying fluoro groups at positions 1 and 3." []
subset: 3:STAR
synonym: "1,3-Difluorbenzol" RELATED [chebi]
synonym: "m-difluorobenzene" RELATED [chemidplus]
synonym: "meta-difluorobenzene" RELATED [nist]
is_a: CHEBI:38582 ! difluorobenzene

[Term]
id: CHEBI:38597
name: triazole
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:35555 ! mancude organic heteromonocyclic parent
is_a: CHEBI:35727 ! triazoles

[Term]
id: CHEBI:38623
name: EC 1.4.3.4 (monoamine oxidase) inhibitor
namespace: chebi_ontology
def: "An EC 1.4.3.* (oxidoreductase acting on donor CH-NH<small><sub>2</sub></small> group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4)." []
subset: 3:STAR
synonym: "adrenalin oxidase inhibitor" RELATED [chebi]
synonym: "adrenalin oxidase inhibitors" RELATED [chebi]
synonym: "adrenaline oxidase inhibitor" RELATED [chebi]
synonym: "adrenaline oxidase inhibitors" RELATED [chebi]
synonym: "amine oxidase (flavin-containing) inhibitor" RELATED [chebi]
synonym: "amine oxidase (flavin-containing) inhibitors" RELATED [chebi]
synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitor" RELATED [chebi]
synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing) inhibitors" RELATED [chebi]
synonym: "amine:oxygen oxidoreductase (deaminating) inhibitor" RELATED [chebi]
synonym: "amine:oxygen oxidoreductase (deaminating) inhibitors" RELATED [chebi]
synonym: "EC 1.4.3.4 (monoamine oxidase) inhibitors" RELATED [chebi]
synonym: "EC 1.4.3.4 inhibitor" RELATED [chebi]
synonym: "EC 1.4.3.4 inhibitors" RELATED [chebi]
synonym: "epinephrine oxidase inhibitor" RELATED [chebi]
synonym: "epinephrine oxidase inhibitors" RELATED [chebi]
synonym: "MAO A inhibitor" RELATED [chebi]
synonym: "MAO A inhibitors" RELATED [chebi]
synonym: "MAO B inhibitor" RELATED [chebi]
synonym: "MAO B inhibitors" RELATED [chebi]
synonym: "MAO inhibitor" RELATED [chebi]
synonym: "MAO inhibitors" RELATED [chebi]
synonym: "MAO-A inhibitor" RELATED [chebi]
synonym: "MAO-A inhibitors" RELATED [chebi]
synonym: "MAO-B inhibitor" RELATED [chebi]
synonym: "MAO-B inhibitors" RELATED [chebi]
synonym: "monoamine oxidase (EC 1.4.3.4) inhibitor" RELATED [chebi]
synonym: "monoamine oxidase (EC 1.4.3.4) inhibitors" RELATED [chebi]
synonym: "monoamine oxidase A inhibitor" RELATED [chebi]
synonym: "monoamine oxidase A inhibitors" RELATED [chebi]
synonym: "monoamine oxidase B inhibitor" RELATED [chebi]
synonym: "monoamine oxidase B inhibitors" RELATED [chebi]
synonym: "monoamine oxidase inhibitor" RELATED [chebi]
synonym: "monoamine oxidase inhibitors" RELATED [chebi]
synonym: "monoamine:O2 oxidoreductase (deaminating) inhibitor" RELATED [chebi]
synonym: "monoamine:O2 oxidoreductase (deaminating) inhibitors" RELATED [chebi]
synonym: "serotonin deaminase inhibitor" RELATED [chebi]
synonym: "serotonin deaminase inhibitors" RELATED [chebi]
synonym: "tyraminase inhibitor" RELATED [chebi]
synonym: "tyraminase inhibitors" RELATED [chebi]
synonym: "tyramine oxidase inhibitor" RELATED [chebi]
synonym: "tyramine oxidase inhibitors" RELATED [chebi]
is_a: CHEBI:76861 ! EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor

[Term]
id: CHEBI:38632
name: membrane transport modulator
namespace: chebi_ontology
def: "Any agent that affects the transport of molecular entities across a biological membrane." []
subset: 3:STAR
synonym: "membrane transport modulators" RELATED [chebi]
is_a: CHEBI:52208 ! biophysical role

[Term]
id: CHEBI:38700
name: organic sodium salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic sodium salt" RELATED [chebi]
synonym: "organic sodium salts" RELATED [chebi]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:26714 ! sodium salt

[Term]
id: CHEBI:38702
name: inorganic sodium salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "inorganic sodium salts" RELATED [chebi]
is_a: CHEBI:24839 ! inorganic salt
is_a: CHEBI:26714 ! sodium salt

[Term]
id: CHEBI:38716
name: carboxylic acid dianion
namespace: chebi_ontology
def: "Any dianion containing at least one carboxy group." []
subset: 3:STAR
synonym: "carboxylic acid dianion" RELATED [chebi]
synonym: "carboxylic acid dianions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion

[Term]
id: CHEBI:38773
name: quinolinemonocarboxylate
namespace: chebi_ontology
def: "A monocarboxylic acid anion that is the monoanion obtained by the deprotonation of the carboxy group attached to the quinoline skeleton" []
subset: 3:STAR
synonym: "quinolinemonocarboxylates" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:26512 ! quinolinemonocarboxylic acid

[Term]
id: CHEBI:38785
name: morpholines
namespace: chebi_ontology
def: "Any compound containing morpholine as part of its structure." []
subset: 3:STAR
is_a: CHEBI:46952 ! oxazinane

[Term]
id: CHEBI:38808
name: calcium channel modulator
namespace: chebi_ontology
def: "A membrane transport modulator that is able to regulate intracellular calcium levels." []
subset: 3:STAR
synonym: "calcium channel modulators" RELATED [chebi]
is_a: CHEBI:38632 ! membrane transport modulator

[Term]
id: CHEBI:38922
name: dibenzofurans
namespace: chebi_ontology
def: "Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof." []
subset: 3:STAR
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:39141
name: Bronsted acid
namespace: chebi_ontology
def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." []
subset: 3:STAR
subset: 3_STAR
synonym: "acide de Bronsted" RELATED [IUPAC]
synonym: "acide de Bronsted" RELATED [iupac]
synonym: "Bronsted-Saeure" RELATED [ChEBI]
synonym: "Bronsted-Saeure" RELATED [chebi]
synonym: "donneur d'hydron" RELATED [IUPAC]
synonym: "donneur d'hydron" RELATED [iupac]
synonym: "hydron donor" RELATED [iupac]
synonym: "hydron donor" RELATED [IUPAC]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:37527 ! acid

[Term]
id: CHEBI:39142
name: Bronsted base
namespace: chebi_ontology
def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." []
subset: 3:STAR
subset: 3_STAR
synonym: "accepteur d'hydron" RELATED [IUPAC]
synonym: "accepteur d'hydron" RELATED [iupac]
synonym: "base de Bronsted" RELATED [IUPAC]
synonym: "base de Bronsted" RELATED [iupac]
synonym: "Bronsted-Base" RELATED [chebi]
synonym: "Bronsted-Base" RELATED [ChEBI]
synonym: "hydron acceptor" RELATED [iupac]
synonym: "hydron acceptor" RELATED [IUPAC]
is_a: CHEBI:15339 ! acceptor
is_a: CHEBI:22695 ! base

[Term]
id: CHEBI:39144
name: Lewis base
namespace: chebi_ontology
def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." []
subset: 3:STAR
subset: 3_STAR
synonym: "base de Lewis" RELATED [IUPAC]
synonym: "base de Lewis" RELATED [iupac]
synonym: "donneur d'une paire d'electrons" RELATED [ChEBI]
synonym: "donneur d'une paire d'electrons" RELATED [chebi]
synonym: "electron donor" RELATED [ChEBI]
synonym: "electron donor" RELATED [chebi]
synonym: "Lewis-Base" RELATED [ChEBI]
synonym: "Lewis-Base" RELATED [chebi]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:22695 ! base

[Term]
id: CHEBI:39146
name: trichostatin
namespace: chebi_ontology
subset: 3:STAR
synonym: "trichostatin" RELATED [chebi]
synonym: "trichostatins" RELATED [chebi]
is_a: CHEBI:49319 ! carbocyclic antibiotic

[Term]
id: CHEBI:39157
name: trichostatic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "(+-)-7-(4-(dimethylamino)phenyl)-4,6-dimethyl-7-oxo-2,4-heptadienoic acid" RELATED [chemidplus]
synonym: "trichostatic acid" RELATED [chemidplus]
is_a: CHEBI:35983 ! 7-oxo monocarboxylic acid
is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid

[Term]
id: CHEBI:39158
name: (R)-trichostatic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "(+)-trichostatic acid" RELATED [chebi]
synonym: "(+)-Trichostatsaeure" RELATED [chebi]
is_a: CHEBI:39157 ! trichostatic acid
relationship: RO:0018039 CHEBI:39159 ! (S)-trichostatic acid

[Term]
id: CHEBI:39159
name: (S)-trichostatic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "(-)-trichostatic acid" RELATED [chebi]
synonym: "(-)-Trichostatsaeure" RELATED [chebi]
is_a: CHEBI:39157 ! trichostatic acid
relationship: RO:0018039 CHEBI:39158 ! (R)-trichostatic acid

[Term]
id: CHEBI:39201
name: phenazines
namespace: chebi_ontology
def: "Any  organonitrogen heterocyclic compound based on a phenazine skeleton and derivatives." []
subset: 3:STAR
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:39208
name: antibiotic insecticide
namespace: chebi_ontology
subset: 1:STAR
synonym: "antibiotic insecticides" RELATED [chebi]
is_a: CHEBI:24852 ! insecticide
is_a: CHEBI:39215 ! antibiotic pesticide

[Term]
id: CHEBI:39209
name: macrolide insecticide
namespace: chebi_ontology
subset: 1:STAR
synonym: "macrolide insecticides" RELATED [chebi]
is_a: CHEBI:39221 ! macrolide pesticide
relationship: RO:0000087 CHEBI:39208 ! has role antibiotic insecticide

[Term]
id: CHEBI:39213
name: avermectin insecticide
namespace: chebi_ontology
subset: 1:STAR
synonym: "avermectin insecticides" RELATED [chebi]
is_a: CHEBI:39209 ! macrolide insecticide
is_a: CHEBI:39220 ! avermectin pesticide

[Term]
id: CHEBI:39214
name: abamectin
namespace: chebi_ontology
def: "Mixture of 80% avermectin B<small><sub>1a</sub></small> and 20% avermectin B<small><sub>1b</sub></small>." []
subset: 3:STAR
synonym: "Abamectin" RELATED [chemidplus]
synonym: "Agri-Mek" RELATED [chemidplus]
synonym: "avermectin B1" RELATED [chemidplus]
synonym: "Avid" RELATED [chemidplus]
synonym: "MK 936" RELATED [chemidplus]
synonym: "Zephyr" RELATED [chemidplus]
is_a: CHEBI:39213 ! avermectin insecticide
is_a: CHEBI:39219 ! avermectin acaricide
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:29534 ! has part avermectin B1a
relationship: BFO:0000051 CHEBI:29537 ! has part avermectin B1b
relationship: RO:0000087 CHEBI:39217 ! has role antibiotic nematicide

[Term]
id: CHEBI:39215
name: antibiotic pesticide
namespace: chebi_ontology
subset: 1:STAR
synonym: "antibiotic pesticides" RELATED [chebi]
is_a: CHEBI:25944 ! pesticide
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:39216
name: antibiotic acaricide
namespace: chebi_ontology
subset: 1:STAR
synonym: "antibiotic acaricides" RELATED [chebi]
is_a: CHEBI:22153 ! acaricide
is_a: CHEBI:39215 ! antibiotic pesticide

[Term]
id: CHEBI:39217
name: antibiotic nematicide
namespace: chebi_ontology
subset: 1:STAR
synonym: "antibiotic nematicides" RELATED [chebi]
is_a: CHEBI:25491 ! nematicide
is_a: CHEBI:39215 ! antibiotic pesticide

[Term]
id: CHEBI:39218
name: macrolide acaricide
namespace: chebi_ontology
subset: 1:STAR
synonym: "macrolide acaricides" RELATED [chebi]
is_a: CHEBI:39221 ! macrolide pesticide
relationship: RO:0000087 CHEBI:39216 ! has role antibiotic acaricide

[Term]
id: CHEBI:39219
name: avermectin acaricide
namespace: chebi_ontology
subset: 1:STAR
synonym: "avermectin acaricides" RELATED [chebi]
is_a: CHEBI:39218 ! macrolide acaricide
is_a: CHEBI:39220 ! avermectin pesticide

[Term]
id: CHEBI:39220
name: avermectin pesticide
namespace: chebi_ontology
subset: 1:STAR
synonym: "avermectin pesticides" RELATED [chebi]
is_a: CHEBI:39221 ! macrolide pesticide

[Term]
id: CHEBI:39221
name: macrolide pesticide
namespace: chebi_ontology
subset: 1:STAR
synonym: "macrolide pesticides" RELATED [chebi]
is_a: CHEBI:25105 ! macrolide antibiotic

[Term]
id: CHEBI:39230
name: emamectin
namespace: chebi_ontology
def: "A mixture of emamectin B<small><sub>1a</sub></small> (major component) and emamectin B<small><sub>1b</sub></small> (minor component)." []
subset: 3:STAR
synonym: "(4''R)- 4''-deoxy-4''-(methylamino)avermectin B1" RELATED [chemidplus]
synonym: "4''-epi-methylamino-4''-deoxyavermectin B1" RELATED [chemidplus]
synonym: "emamectin" RELATED [chemidplus]
is_a: CHEBI:39213 ! avermectin insecticide
relationship: BFO:0000051 CHEBI:39231 ! has part emamectin B1a
relationship: BFO:0000051 CHEBI:39232 ! has part emamectin B1b

[Term]
id: CHEBI:39231
name: emamectin B1a
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:50346 ! emamectins

[Term]
id: CHEBI:39232
name: emamectin B1b
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-3-O-methyl-4-O-[2,4,6-trideoxy-3-O-methyl-4-(methylamino)-alpha-L-arabino-hexopyranosyl]-alpha-L-arabino-hexopyranoside" RELATED [iupac]
is_a: CHEBI:50346 ! emamectins

[Term]
id: CHEBI:39270
name: naphthofuran
namespace: chebi_ontology
subset: 3:STAR
synonym: "naphthofurans" RELATED [chebi]
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:39317
name: growth regulator
namespace: chebi_ontology
def: "Any chemical substance that inhibits the life-cycle of an organism." []
subset: 3:STAR
synonym: "growth regulators" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:39410
name: 1,2,4-triazines
namespace: chebi_ontology
def: "Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure." []
subset: 3:STAR
is_a: CHEBI:38102 ! triazines

[Term]
id: CHEBI:39418
name: straight-chain saturated fatty acid
namespace: chebi_ontology
def: "Any saturated fatty acid lacking a side-chain." []
subset: 3:STAR
synonym: "straight-chain saturated fatty acid" RELATED [chebi]
synonym: "straight-chain saturated fatty acids" RELATED [chebi]
is_a: CHEBI:26607 ! saturated fatty acid
is_a: CHEBI:59202 ! straight-chain fatty acid
relationship: RO:0018034 CHEBI:58954 ! straight-chain saturated fatty acid anion

[Term]
id: CHEBI:39430
name: dioxolane
namespace: chebi_ontology
subset: 3:STAR
synonym: "dioxolanes" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:39442
name: fluorescent probe
namespace: chebi_ontology
def: "A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy." []
subset: 3:STAR
is_a: CHEBI:50406 ! probe

[Term]
id: CHEBI:39446
name: pyrimidine ribonucleosides
namespace: chebi_ontology
alt_id: CHEBI:13784
alt_id: CHEBI:26445
alt_id: CHEBI:7263
subset: 3:STAR
is_a: CHEBI:18254 ! ribonucleoside
is_a: CHEBI:26440 ! pyrimidine nucleoside

[Term]
id: CHEBI:39447
name: pyrimidines
namespace: chebi_ontology
alt_id: CHEBI:13681
alt_id: CHEBI:26448
def: "Any compound having a pyrimidine as part of its structure." []
subset: 3:STAR
is_a: CHEBI:38313 ! diazines

[Term]
id: CHEBI:39474
name: polyazaalkane
namespace: chebi_ontology
def: "Any azaalkane in which two or more carbons in the chain are replaced by nitrogen." []
subset: 3:STAR
synonym: "polyazaalkanes" RELATED [chebi]
is_a: CHEBI:46686 ! azaalkane
is_a: CHEBI:88061 ! polyamine

[Term]
id: CHEBI:39745
name: dihydrogenphosphate
namespace: chebi_ontology
alt_id: CHEBI:29137
alt_id: CHEBI:39739
def: "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." []
subset: 3:STAR
synonym: "[PO2(OH)2](-)" RELATED [iupac]
synonym: "DIHYDROGENPHOSPHATE ION" RELATED [pdb-ccd]
synonym: "H2PO4(-)" RELATED [iupac]
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: RO:0018034 CHEBI:43474 ! hydrogenphosphate

[Term]
id: CHEBI:3992
name: cyclic ketone
namespace: chebi_ontology
subset: 3:STAR
synonym: "Cyclic ketone" RELATED [kegg.compound]
is_a: CHEBI:17087 ! ketone

[Term]
id: CHEBI:40009
name: D-cycloserine
namespace: chebi_ontology
alt_id: CHEBI:4030
def: "A 4-amino-1,2-oxazolidin-3-one that has <i>R</i> configuration. It is an antibiotic produced by <em>Streptomyces garyphalus</em> or <em>S. orchidaceus</em> and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of <small>D</small>-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of <small>L</small>-alanine racemase (which forms <small>D</small>-alanine from <small>L</small>-alanine) and  <small>D</small>-alanine—<small>D</small>-alanine ligase (which incorporates <small>D</small>-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis)." []
subset: 3:STAR
synonym: "(+)-4-amino-3-isoxazolidinone" RELATED [chemidplus]
synonym: "(+)-cycloserine" RELATED [chebi]
synonym: "(R)-4-AMINO-ISOXAZOLIDIN-3-ONE" RELATED [pdb-ccd]
synonym: "alpha-Cycloserine" RELATED [nist]
synonym: "cyclo-D-serine" RELATED [chemidplus]
synonym: "D-(+)-cycloserine" RELATED [chebi]
synonym: "D-4-amino-3-isoxazolidinone" RELATED [chemidplus]
synonym: "D-4-amino-3-isoxazolidone" RELATED [chemidplus]
synonym: "D-Cycloserine" RELATED [chemidplus, kegg.compound]
synonym: "DCS" RELATED [chemidplus]
synonym: "orientomycin" RELATED [chemidplus]
synonym: "PA 94" RELATED [chemidplus]
synonym: "PA-94" RELATED [chemidplus]
synonym: "Ro-1-9213" RELATED [chemidplus]
is_a: CHEBI:23503 ! 4-amino-1,2-oxazolidin-3-one
is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic
is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0000087 CHEBI:35221 ! has role antimetabolite
relationship: RO:0000087 CHEBI:64571 ! has role NMDA receptor agonist
relationship: RO:0018033 CHEBI:75929 ! D-cycloserine(1+)
relationship: RO:0018036 CHEBI:74159 ! D-cycloserine zwitterion
relationship: RO:0018039 CHEBI:75592 ! L-cycloserine

[Term]
id: CHEBI:4031
name: cyclosporin A
namespace: chebi_ontology
alt_id: CHEBI:63586
alt_id: CHEBI:91802
def: "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." []
subset: 3:STAR
synonym: "(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)" RELATED [chebi]
synonym: "1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]" RELATED [jcbn]
synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" RELATED [chebi]
synonym: "Antibiotic S 7481F1" RELATED [chemidplus]
synonym: "Ciclosporin" RELATED [kegg.compound]
synonym: "Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)" RELATED [chemidplus]
synonym: "Cyclosporin A" RELATED [kegg.compound]
synonym: "cyclosporin A" RELATED [uniprot_ft]
synonym: "Cyclosporine" RELATED [chemidplus, kegg.compound]
is_a: CHEBI:24613 ! homodetic cyclic peptide
relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:35842 ! has role antirheumatic drug
relationship: RO:0000087 CHEBI:37153 ! has role EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor
relationship: RO:0000087 CHEBI:49167 ! has role anti-asthmatic drug
relationship: RO:0000087 CHEBI:50177 ! has role dermatologic drug
relationship: RO:0000087 CHEBI:50903 ! has role carcinogenic agent

[Term]
id: CHEBI:404903
name: ertapenem
namespace: chebi_ontology
alt_id: CHEBI:471574
def: "Meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal  and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract." []
subset: 3:STAR
synonym: "(1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid" RELATED [chebi]
synonym: "(4R,5S,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [chembl]
synonym: "ERTAPENEM" RELATED [chembl]
is_a: CHEBI:46634 ! carbapenemcarboxylic acid
is_a: CHEBI:46770 ! pyrrolidinecarboxamide
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:60071 ! ertapenem(1-)

[Term]
id: CHEBI:40909
name: azoxystrobin
namespace: chebi_ontology
def: "An aryloxypyrimidine having a 4,6-diphenoxypyrimidine  skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c<small><sub>1</sub></small>, it is used widely as a fungicide in agriculture." []
subset: 3:STAR
synonym: "(alphaE)-2-[[6-(2-cyanophenoxy)-4-pyrimidinyl]oxy]-alpha-(methoxymethylene) benzeneacetic acid methyl ester" RELATED [chebi]
synonym: "methyl (E)-2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3-methoxyacrylate" RELATED [chebi]
is_a: CHEBI:18379 ! nitrile
is_a: CHEBI:47985 ! enol ether
is_a: CHEBI:48535 ! aryloxypyrimidine
is_a: CHEBI:86484 ! methoxyacrylate strobilurin antifungal agent
relationship: RO:0000087 CHEBI:141153 ! has role quinone outside inhibitor
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:41032
name: 5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium
namespace: chebi_ontology
subset: 1:STAR
synonym: "5-METHYL-1,2,4-TRIAZOLO[3,4-B]BENZOTHIAZOLE" RELATED [pdb-ccd]
synonym: "5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium" RELATED [pdb-ccd]
is_a: CHEBI:25697 ! organic cation
relationship: RO:0018034 CHEBI:81783 ! tricyclazole

[Term]
id: CHEBI:41275
name: 1H-benzimidazole
namespace: chebi_ontology
alt_id: CHEBI:3028
alt_id: CHEBI:41272
def: "The 1<em>H</em>-tautomer of benzimidazole." []
subset: 3:STAR
synonym: "1,3-benzodiazole" RELATED [chemidplus]
synonym: "1,3-diazaindene" RELATED [chemidplus]
synonym: "azindole" RELATED [chemidplus]
synonym: "BENZIMIDAZOLE" EXACT [PDBeChem]
synonym: "BENZIMIDAZOLE" RELATED [pdb-ccd]
synonym: "Benzimidazole" EXACT [KEGG_COMPOUND]
synonym: "Benzimidazole" RELATED [kegg.compound]
synonym: "benzimidazole" EXACT [IUPAC]
synonym: "benzimidazole" RELATED [iupac]
synonym: "benzoglyoxaline" RELATED [chemidplus]
synonym: "Hbim" RELATED [iupac]
synonym: "Hbzim" RELATED [iupac]
synonym: "o-benzimidazole" RELATED [nist]
is_a: CHEBI:36622 ! benzimidazole
is_a: CHEBI:38180 ! polycyclic heteroarene
relationship: RO:0018034 CHEBI:33173 ! benzimidazolide
relationship: RO:0018036 CHEBI:36623 ! 4H-benzimidazole
relationship: RO:0018036 CHEBI:36639 ! 2H-benzimidazole
relationship: RO:0018036 CHEBI:36641 ! 3aH-benzimidazole

[Term]
id: CHEBI:41609
name: carbonate
namespace: chebi_ontology
alt_id: CHEBI:29201
alt_id: CHEBI:41605
subset: 3:STAR
synonym: "[CO3](2-)" RELATED [iupac]
synonym: "carbonate" RELATED [iupac]
synonym: "CARBONATE ION" RELATED [pdb-ccd]
synonym: "CO3(2-)" RELATED [chebi]
synonym: "Karbonat" RELATED [chebi]
is_a: CHEBI:35604 ! carbon oxoanion
relationship: RO:0018033 CHEBI:17544 ! hydrogencarbonate

[Term]
id: CHEBI:4167
name: D-glucopyranose
namespace: chebi_ontology
def: "A glucopyranose having <small>D</small>-configuration." []
subset: 3:STAR
synonym: "D-Glc" RELATED [chebi]
synonym: "D-Glcp" RELATED [chebi]
synonym: "D-Glucose" RELATED [kegg.compound]
synonym: "D-glucose" RELATED [uniprot_ft]
synonym: "Dextrose" RELATED [kegg.compound]
synonym: "Glc-OH" RELATED [chebi]
synonym: "Glucose" RELATED [kegg.compound]
synonym: "glucose" RELATED [chebi]
synonym: "Grape sugar" RELATED [kegg.compound]
is_a: CHEBI:17634 ! D-glucose
is_a: CHEBI:37661 ! glucopyranose
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite

[Term]
id: CHEBI:417636
name: 4-\{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl\}-thiazol-2-yl-ammonium
namespace: chebi_ontology
subset: 2:STAR
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:33575 ! carboxylic acid
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CHEBI:4194
name: D-hexose
namespace: chebi_ontology
def: "A hexose that has <small>D</small>-configuration at position 5." []
subset: 3:STAR
synonym: "a D-hexose" RELATED [uniprot_ft]
synonym: "D-Hexose" RELATED [kegg.compound]
synonym: "D-hexoses" RELATED [chebi]
is_a: CHEBI:18133 ! hexose

[Term]
id: CHEBI:41948
name: eflornithine
namespace: chebi_ontology
alt_id: CHEBI:41946
alt_id: CHEBI:4761
def: "A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2." []
subset: 3:STAR
synonym: "alpha-(Difluoromethyl)-DL-ornithine" RELATED [drugcentral]
synonym: "ALPHA-DIFLUOROMETHYLORNITHINE" RELATED [pdb-ccd]
synonym: "alpha-difluoromethylornithine" RELATED [chemidplus]
synonym: "DFMO" RELATED [chemidplus]
synonym: "DL-Ornithine, 2-(difluoromethyl)-" RELATED [kegg.compound]
synonym: "Eflornithine" RELATED [kegg.compound]
is_a: CHEBI:24068 ! fluoroamino acid
is_a: CHEBI:33704 ! alpha-amino acid
relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug
relationship: RO:0018038 CHEBI:18257 ! ornithine

[Term]
id: CHEBI:42266
name: ethane
namespace: chebi_ontology
alt_id: CHEBI:23975
alt_id: CHEBI:42260
def: "An alkane comprising of two carbon atoms." []
subset: 3:STAR
synonym: "Aethan" RELATED [chebi]
synonym: "bimethyl" RELATED [nist]
synonym: "C2H6" RELATED [chebi]
synonym: "CH3-CH3" RELATED [iupac]
synonym: "dimethyl" RELATED [nist]
synonym: "Ethan" RELATED [chebi]
synonym: "ETHANE" EXACT [PDBeChem]
synonym: "ETHANE" RELATED [pdb-ccd]
synonym: "ethane" RELATED [uniprot_ft]
synonym: "ethyl hydride" RELATED [nist]
synonym: "methylmethane" RELATED [nist]
synonym: "R-170" RELATED [chebi]
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:18310 ! alkane
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant

[Term]
id: CHEBI:42355
name: erythromycin A
namespace: chebi_ontology
alt_id: CHEBI:112506
alt_id: CHEBI:23950
alt_id: CHEBI:28672
alt_id: CHEBI:42352
alt_id: CHEBI:4841
alt_id: CHEBI:4843
def: "An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-<em>C</em>-methyl-3-<em>O</em>-methyl-α-<small>L</small>-<i>ribo</i>-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-β-<small>D</small>-<i>xylo</i>-hexopyranosyl residues attahced at positions 4 and 6 respectively." []
subset: 3:STAR
synonym: "(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione" RELATED [iupac]
synonym: "3''-O-demethylerythromycin" RELATED [chemidplus]
synonym: "Abomacetin" RELATED [kegg.compound]
synonym: "erthromycin" RELATED [chebi]
synonym: "ERYTHROMYCIN" EXACT [ChEMBL]
synonym: "ERYTHROMYCIN" RELATED [chembl]
synonym: "Erythromycin" EXACT [ChEMBL, KEGG_COMPOUND]
synonym: "Erythromycin" RELATED [chembl, kegg.compound]
synonym: "ERYTHROMYCIN A" RELATED [pdb-ccd]
synonym: "Erythromycin A" RELATED [chembl, kegg.compound]
synonym: "Erythromycin C" RELATED [kegg.compound]
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:48923 ! erythromycin
relationship: RO:0018033 CHEBI:64268 ! erythromycin A(1+)
relationship: RO:0018038 CHEBI:48848 ! erythronolide A

[Term]
id: CHEBI:42485
name: formyl group
namespace: chebi_ontology
alt_id: CHEBI:24089
alt_id: CHEBI:42480
subset: 3:STAR
synonym: "-CH(O)" RELATED [iupac]
synonym: "-CHO" RELATED [iupac]
synonym: "Fo" RELATED [iubmb]
synonym: "FORMYL GROUP" RELATED [pdb-ccd]
synonym: "H-CO-" RELATED [iupac]
synonym: "methanoyl" RELATED [iupac]
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: RO:0018037 CHEBI:30751 ! formic acid

[Term]
id: CHEBI:43176
name: hydroxy group
namespace: chebi_ontology
alt_id: CHEBI:24706
alt_id: CHEBI:43171
subset: 3:STAR
subset: 3_STAR
synonym: "-OH" RELATED [IUPAC]
synonym: "-OH" RELATED [iupac]
synonym: "HYDROXY GROUP" EXACT [PDBeChem]
synonym: "HYDROXY GROUP" RELATED [pdb-ccd]
synonym: "hydroxy group" EXACT [UniProt]
synonym: "hydroxy group" RELATED [uniprot_ft]
synonym: "hydroxyl" RELATED [ChEBI]
synonym: "hydroxyl" RELATED [chebi]
synonym: "hydroxyl group" RELATED [ChEBI]
synonym: "hydroxyl group" RELATED [chebi]
xref: PDBeChem:OH
is_a: CHEBI:33246 ! inorganic group

[Term]
id: CHEBI:43254
name: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one
namespace: chebi_ontology
subset: 1:STAR
synonym: "(4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one" RELATED [pdb-ccd]
synonym: "4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE" RELATED [pdb-ccd]
is_a: CHEBI:38337 ! pyrimidone
relationship: RO:0018036 CHEBI:17568 ! uracil

[Term]
id: CHEBI:43474
name: hydrogenphosphate
namespace: chebi_ontology
alt_id: CHEBI:29139
alt_id: CHEBI:43470
def: "A phosphate ion that is the conjugate base of dihydrogenphosphate." []
subset: 3:STAR
synonym: "[P(OH)O3](2-)" RELATED [molbase]
synonym: "[PO3(OH)](2-)" RELATED [iupac]
synonym: "HPO4(2-)" RELATED [iupac]
synonym: "hydrogen phosphate" RELATED [chebi]
synonym: "HYDROGENPHOSPHATE ION" RELATED [pdb-ccd]
synonym: "INORGANIC PHOSPHATE GROUP" RELATED [pdb-ccd]
synonym: "phosphate" RELATED [uniprot_ft]
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: RO:0000087 CHEBI:23357 ! has role cofactor
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0018033 CHEBI:39745 ! dihydrogenphosphate
relationship: RO:0018034 CHEBI:18367 ! phosphate(3-)

[Term]
id: CHEBI:43968
name: meropenem
namespace: chebi_ontology
def: "A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively." []
subset: 3:STAR
synonym: "(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-YLTHIO]-6-[(R)-1-HYDROXYETHYL]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC ACID" RELATED [pdb-ccd]
synonym: "(4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "Antibiotic SM 7338" RELATED [drugbank]
synonym: "MEPM" RELATED [chebi]
synonym: "Meropenem" RELATED [chemidplus]
synonym: "meropenem anhydrous" RELATED [chemidplus]
is_a: CHEBI:16385 ! organic sulfide
is_a: CHEBI:46634 ! carbapenemcarboxylic acid
is_a: CHEBI:46770 ! pyrrolidinecarboxamide
is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen

[Term]
id: CHEBI:44137
name: tiamulin
namespace: chebi_ontology
alt_id: CHEBI:29695
def: "A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by <em>Serpulina hyodysenteriae</em>." []
subset: 3:STAR
is_a: CHEBI:16385 ! organic sulfide
is_a: CHEBI:33308 ! carboxylic ester
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:38032 ! carbotricyclic compound
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:50996 ! tertiary amino compound
is_a: CHEBI:52557 ! tetracyclic diterpenoid
is_a: CHEBI:72588 ! semisynthetic derivative
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018038 CHEBI:8269 ! Pleuromutilin

[Term]
id: CHEBI:44976
name: phosphonic acid
namespace: chebi_ontology
alt_id: CHEBI:26067
def: "A phosphorus oxoacid that consists of a single pentavalent phosphorus covalently bound via single bonds to a single hydrogen and two hydroxy groups and via a double bond to an oxygen. The parent of the class of phosphonic acids." []
subset: 3:STAR
synonym: "(HO)2HPO" RELATED [nist]
synonym: "[PHO(OH)2]" RELATED [iupac]
synonym: "H2PHO3" RELATED [iupac]
synonym: "H3PO3" RELATED [chebi]
synonym: "HPO(OH)2" RELATED [iupac]
synonym: "Phosphite" RELATED [kegg.compound]
synonym: "Phosphonate" RELATED [kegg.compound]
synonym: "Phosphonic acid" RELATED [kegg.compound]
synonym: "phosphonic acid" RELATED [chebi]
synonym: "Phosphonsaeure" RELATED [chebi]
is_a: CHEBI:26069 ! phosphonic acids
is_a: CHEBI:33457 ! phosphorus oxoacid
relationship: RO:0000087 CHEBI:24127 ! has role fungicide
relationship: RO:0018034 CHEBI:33462 ! phosphonate(1-)
relationship: RO:0018036 CHEBI:36361 ! phosphorous acid

[Term]
id: CHEBI:45064
name: phosphite(3-)
namespace: chebi_ontology
alt_id: CHEBI:29197
alt_id: CHEBI:45060
def: "A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid." []
subset: 3:STAR
synonym: "[PO3](3-)" RELATED [iupac]
synonym: "Phosphit" RELATED [chebi]
synonym: "phosphite" RELATED [iupac]
synonym: "PHOSPHITE ION" RELATED [pdb-ccd]
synonym: "PO3(3-)" RELATED [iupac]
is_a: CHEBI:26045 ! phosphite ion
is_a: CHEBI:79387 ! trivalent inorganic anion
relationship: RO:0018033 CHEBI:29259 ! hydrogenphosphite

[Term]
id: CHEBI:45081
name: pentamidine
namespace: chebi_ontology
alt_id: CHEBI:45077
alt_id: CHEBI:7976
def: "A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A  trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease." []
subset: 3:STAR
synonym: "1,5-bis(4-amidinophenoxy)pentane" RELATED [chebi]
synonym: "4,4'-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamide" RELATED [chemidplus]
synonym: "4,4'-(pentamethylenedioxy)dibenzamidine" RELATED [chemidplus]
synonym: "4,4'-Diamidinodiphenoxypentane" RELATED [drugbank]
synonym: "p,p'-(pentamethylenedioxy)dibenzamidine" RELATED [chemidplus]
synonym: "pentamidin" RELATED [drugcentral]
synonym: "Pentamidine" RELATED [kegg.compound]
is_a: CHEBI:35359 ! carboxamidine
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:46786 ! diether
relationship: RO:0000087 CHEBI:130181 ! has role calmodulin antagonist
relationship: RO:0000087 CHEBI:136651 ! has role S100 calcium-binding protein B inhibitor
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug
relationship: RO:0000087 CHEBI:60643 ! has role NMDA receptor antagonist
relationship: RO:0000087 CHEBI:63673 ! has role chemokine receptor 5 antagonist
relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent
relationship: RO:0000087 CHEBI:76395 ! has role EC 2.3.1.48 (histone acetyltransferase) inhibitor
relationship: RO:0018033 CHEBI:64383 ! pentamidinium(2+)

[Term]
id: CHEBI:4511
name: dicloxacillin
namespace: chebi_ontology
def: "A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "Dicloxacillin" RELATED [kegg.compound]
is_a: CHEBI:17334 ! penicillin
is_a: CHEBI:23697 ! dichlorobenzene
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:52017 ! dicloxacillin(1-)

[Term]
id: CHEBI:4520
name: diethofencarb
namespace: chebi_ontology
def: "A carbamate ester that is the isopropyl ester of (3,4-diethoxyphenyl)carbamic acid. A fungicide with strong activity against <em>Botrytis cinerea</em> and benzimidazole-resistant strains of <em>Botryis</em> spp." []
subset: 3:STAR
synonym: "1-Methylethyl (3,4-diethoxyphenyl)carbamate" RELATED [chemidplus]
synonym: "1-methylethyl N-(3,4-diethoxyphenyl)carbamate" RELATED [pesticides]
synonym: "isopropyl (3,4-diethoxyphenyl)carbamate" RELATED [iupac]
synonym: "Isopropyl 3,4-diethoxycarbanilate" RELATED [chemidplus]
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:87066 ! carbanilate fungicide
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018038 CHEBI:17296 ! aniline

[Term]
id: CHEBI:45285
name: pyrazinecarboxamide
namespace: chebi_ontology
alt_id: CHEBI:45281
alt_id: CHEBI:8656
def: "A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis." []
subset: 3:STAR
synonym: "2-carbamylpyrazine" RELATED [chemidplus]
synonym: "2-pyrazinecarboxamide" RELATED [chemidplus]
synonym: "Pyrazinamide" RELATED [kegg.compound]
synonym: "pyrazinamide" RELATED [uniprot_ft]
synonym: "pyrazine carboxamide" RELATED [nist]
synonym: "PYRAZINE-2-CARBOXAMIDE" EXACT [PDBeChem]
synonym: "PYRAZINE-2-CARBOXAMIDE" RELATED [pdb-ccd]
synonym: "pyrazineamide" RELATED [nist]
synonym: "Pyrazinoic acid amide" RELATED [kegg.compound]
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:38314 ! pyrazines
is_a: CHEBI:83628 ! N-acylammonia
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0000087 CHEBI:50266 ! has role prodrug

[Term]
id: CHEBI:45367
name: rifabutin
namespace: chebi_ontology
alt_id: CHEBI:45364
alt_id: CHEBI:8857
subset: 3:STAR
synonym: "1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV" RELATED [chemidplus]
synonym: "4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S" RELATED [chemidplus]
synonym: "4-N-isobutylspiropiperidylrifamycin S" RELATED [chemidplus]
synonym: "Mycobutin (TN)" RELATED [kegg.drug]
synonym: "Rifabutin" RELATED [kegg.compound, kegg.drug]
is_a: CHEBI:26580 ! rifamycins
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent

[Term]
id: CHEBI:45373
name: sulfanilamide
namespace: chebi_ontology
alt_id: CHEBI:45370
alt_id: CHEBI:9333
def: "A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position." []
subset: 3:STAR
synonym: "4-aminobenzene sulfonic acid amide" RELATED [chebi]
synonym: "4-azanylbenzenesulfonamide" RELATED [iupac]
synonym: "p-aminobenzenesulfamide" RELATED [nist]
synonym: "p-aminobenzenesulfonamide" RELATED [nist]
synonym: "para-aminobenzenesulfonamide" RELATED [chebi]
synonym: "Prontosil album" RELATED [kegg.compound]
synonym: "SA" RELATED [chebi]
synonym: "Streptocide" RELATED [nist]
synonym: "Sulfamine" RELATED [kegg.compound]
synonym: "sulfamine" RELATED [nist]
synonym: "SULFANILAMIDE" RELATED [pdb-ccd]
synonym: "Sulfanilamide" RELATED [kegg.compound]
synonym: "sulphanilamide" RELATED [chebi]
is_a: CHEBI:48975 ! substituted aniline
is_a: CHEBI:87228 ! sulfonamide antibiotic
relationship: RO:0000087 CHEBI:23018 ! has role EC 4.2.1.1 (carbonic anhydrase) inhibitor
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen

[Term]
id: CHEBI:45599
name: dodecyl hydrogen sulfate
namespace: chebi_ontology
alt_id: CHEBI:32953
alt_id: CHEBI:45595
subset: 3:STAR
synonym: "DODECYL SULFATE" EXACT [PDBeChem]
synonym: "DODECYL SULFATE" RELATED [pdb-ccd]
synonym: "lauryl sulfuric acid" RELATED [chemidplus]
synonym: "monododecyl hydrogen sulfate" RELATED [chemidplus]
synonym: "sulfuric acid, monododecyl ester" RELATED [chemidplus]
is_a: CHEBI:29281 ! alkyl sulfate
relationship: RO:0018034 CHEBI:23872 ! dodecyl sulfate

[Term]
id: CHEBI:45615
name: salicylhydroxamic acid
namespace: chebi_ontology
alt_id: CHEBI:9007
def: "A hydroxamic acid that is <em>N</em>-hydroxybenzamide carrying a phenolic hydroxy group at position 2." []
subset: 3:STAR
synonym: "2-Hydroxybenzhydroxamic acid" RELATED [chemidplus]
synonym: "2-Hydroxybenzohydroxamic acid" RELATED [chemidplus]
synonym: "o-Hydroxybenzohydroxamic acid" RELATED [chemidplus]
synonym: "Salicylohydroximic acid" RELATED [chemidplus]
synonym: "SHAM" RELATED [chebi]
is_a: CHEBI:24650 ! hydroxamic acid
is_a: CHEBI:33853 ! phenols
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug
relationship: RO:0000087 CHEBI:50635 ! has role EC 3.5.1.5 (urease) inhibitor
relationship: RO:0000087 CHEBI:79093 ! has role EC 1.11.2.2 (myeloperoxidase) inhibitor

[Term]
id: CHEBI:45696
name: hydrogensulfate
namespace: chebi_ontology
alt_id: CHEBI:29199
alt_id: CHEBI:45693
subset: 3:STAR
synonym: "[SO3(OH)](-)" RELATED [iupac]
synonym: "HSO4(-)" RELATED [iupac]
synonym: "HYDROGEN SULFATE" RELATED [pdb-ccd]
synonym: "hydrogensulfate" RELATED [iupac]
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: RO:0018033 CHEBI:26836 ! sulfuric acid
relationship: RO:0018034 CHEBI:16189 ! sulfate

[Term]
id: CHEBI:45924
name: trimethoprim
namespace: chebi_ontology
alt_id: CHEBI:45921
alt_id: CHEBI:9731
def: "An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge." []
subset: 3:STAR
synonym: "2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine" RELATED [nist]
synonym: "5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine" RELATED [nist]
synonym: "Proloprim" RELATED [chemidplus]
synonym: "TRIMETHOPRIM" RELATED [pdb-ccd]
synonym: "Trimethoprim" RELATED [kegg.compound]
synonym: "Trimpex" RELATED [chemidplus]
is_a: CHEBI:38338 ! aminopyrimidine
is_a: CHEBI:51683 ! methoxybenzenes
relationship: RO:0000087 CHEBI:35498 ! has role diuretic
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50683 ! has role EC 1.5.1.3 (dihydrofolate reductase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen

[Term]
id: CHEBI:45979
name: thiabendazole
namespace: chebi_ontology
alt_id: CHEBI:45977
alt_id: CHEBI:9526
def: "A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including <em>Aspergillus, Botrytis, Cladosporium</em> and <em>Fusarium</em>." []
subset: 3:STAR
synonym: "2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE" EXACT [PDBeChem]
synonym: "2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE" RELATED [pdb-ccd]
synonym: "2-(1,3-thiazol-4-yl)benzimidazole" RELATED [pesticides]
synonym: "2-(4-thiazolyl)-1H-benzimidazole" RELATED [pesticides]
synonym: "2-(thiazol-4-yl)benzimidazole" RELATED [pesticides]
synonym: "4-(2-benzimidazolyl)thiazole" RELATED [chemidplus]
synonym: "MK 360" RELATED [chemidplus]
synonym: "TBZ" RELATED [chemidplus]
synonym: "Thiabendazole" RELATED [kegg.compound]
synonym: "Tiabendazole" RELATED [kegg.compound]
is_a: CHEBI:38418 ! 1,3-thiazoles
is_a: CHEBI:87036 ! benzimidazole fungicide
relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018040 CHEBI:41275 ! 1H-benzimidazole

[Term]
id: CHEBI:46024
name: trichostatin A
namespace: chebi_ontology
alt_id: CHEBI:39145
alt_id: CHEBI:46022
subset: 3:STAR
synonym: "(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide" RELATED [chemidplus]
synonym: "TRICHOSTATIN A" RELATED [pdb-ccd]
synonym: "TSA" RELATED [chemidplus]
is_a: CHEBI:24650 ! hydroxamic acid
is_a: CHEBI:39146 ! trichostatin
is_a: CHEBI:86478 ! antibiotic antifungal agent
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:61115 ! has role EC 3.5.1.98 (histone deacetylase) inhibitor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018038 CHEBI:39158 ! (R)-trichostatic acid

[Term]
id: CHEBI:46077
name: 4H-1,2,4-triazole
namespace: chebi_ontology
alt_id: CHEBI:35548
alt_id: CHEBI:46076
subset: 3:STAR
synonym: "1,2,4-TRIAZOLE" EXACT [PDBeChem]
synonym: "1,2,4-TRIAZOLE" RELATED [pdb-ccd]
is_a: CHEBI:35560 ! 1,2,4-triazole
relationship: RO:0018036 CHEBI:35550 ! 1H-1,2,4-triazole
relationship: RO:0018036 CHEBI:35561 ! 3H-1,2,4-triazole

[Term]
id: CHEBI:46081
name: fluconazole
namespace: chebi_ontology
alt_id: CHEBI:46079
alt_id: CHEBI:5099
def: "A member of the class of  triazoles that is propan-2-ol substituted at position 1 and 3 by 1<em>H</em>-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis." []
subset: 3:STAR
synonym: "2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol" RELATED [chemidplus]
synonym: "2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL" RELATED [pdb-ccd]
synonym: "Elazor" RELATED [chemidplus]
synonym: "fluconazole" RELATED [uniprot_ft]
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:38582 ! difluorobenzene
is_a: CHEBI:87071 ! conazole antifungal drug
is_a: CHEBI:87101 ! triazole antifungal drug
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0018038 CHEBI:38584 ! 1,3-difluorobenzene
relationship: RO:0018040 CHEBI:35550 ! 1H-1,2,4-triazole

[Term]
id: CHEBI:46416
name: virginiamycin S1
namespace: chebi_ontology
alt_id: CHEBI:9998
def: "A cyclodepsipeptide that is <em>N</em>-(3-hydroxypicolinoyl)-<small>L</small>-threonyl-<small>D</small>-α-aminobutyryl-<small>L</small>-prolyl-<em>N</em>-methyl-<small>L</small>-phenylalanyl-4-oxo-<small>L</small>-pipecoloyl-<small>L</small>-2-phenylglycine in which the carboxy group of the 2-phenylglycine moiety has undergone formal intramolecular condensation with the hydroxy group of the <em>N</em>-(3-hydroxypicolinoyl)-<small>L</small>-threonyl to give the corresponding 19-membered ring lactone. It is one of the two major components of the antibacterial drug virginiamycin, produced by <em>Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus,</em> and others." []
subset: 3:STAR
synonym: "N-((3-hydroxy-2-pyridinyl)carbonyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine rho-lactone" RELATED [chemidplus]
synonym: "N-(3-hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L-prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2-phenylglycine rho-lactone" RELATED [chemidplus]
synonym: "virginiamycin factor S" RELATED [chemidplus]
synonym: "Virginiamycin S1" RELATED [kegg.compound]
synonym: "virginiamycin S1" RELATED [chemidplus]
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:35213 ! cyclodepsipeptide
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:46577
name: dextrofloxacin
namespace: chebi_ontology
def: "The (<i>R</i>)-enantiomer of ofloxacin." []
subset: 3:STAR
synonym: "(+)-ofloxacin" RELATED [chebi]
synonym: "(R)-(+)-ofloxacin" RELATED [chebi]
synonym: "(R)-ofloxacin" RELATED [chebi]
synonym: "D-levofloxacin" RELATED [drugbank]
synonym: "D-ofloxacin" RELATED [chemidplus]
synonym: "dextrofloxacine" RELATED [pdb-ccd]
synonym: "DR 3354" RELATED [chebi]
synonym: "DR-3354" RELATED [chebi]
synonym: "DR3354" RELATED [chebi]
synonym: "R-(+)-ofloxacin" RELATED [chebi]
synonym: "R-ofloxacin" RELATED [chemidplus]
is_a: CHEBI:194135 ! 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0018039 CHEBI:63598 ! levofloxacin

[Term]
id: CHEBI:46629
name: oxo group
namespace: chebi_ontology
alt_id: CHEBI:29353
alt_id: CHEBI:44607
subset: 3:STAR
subset: 3_STAR
synonym: "=O" RELATED [IUPAC]
synonym: "=O" RELATED [iupac]
synonym: "OXO GROUP" EXACT [PDBeChem]
synonym: "OXO GROUP" RELATED [pdb-ccd]
xref: PDBeChem:O
is_a: CHEBI:33246 ! inorganic group

[Term]
id: CHEBI:46633
name: carbapenems
namespace: chebi_ontology
def: "The class of β-lactam antibiotics that whose members have a carbapenem skeleton which is variously substituted at positions 3, 4, and 6." []
subset: 3:STAR
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:27933 ! beta-lactam antibiotic
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent

[Term]
id: CHEBI:46634
name: carbapenemcarboxylic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "carbapenemcarboxylic acids" RELATED [chebi]
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:46633 ! carbapenems

[Term]
id: CHEBI:46662
name: mineral
namespace: chebi_ontology
def: "In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals')." []
subset: 3:STAR
synonym: "mineral" RELATED [chebi]
synonym: "Minerale" RELATED [chebi]
synonym: "minerales" RELATED [chebi]
synonym: "minerals" RELATED [chebi]
synonym: "mineraux" RELATED [chebi]
is_a: CHEBI:59999 ! chemical substance

[Term]
id: CHEBI:46686
name: azaalkane
namespace: chebi_ontology
subset: 3:STAR
synonym: "azaalkanes" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:46687
name: diazaalkane
namespace: chebi_ontology
subset: 3:STAR
synonym: "diazaalkanes" RELATED [chebi]
is_a: CHEBI:39474 ! polyazaalkane

[Term]
id: CHEBI:46733
name: oxabicycloalkane
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxabicycloalkanes" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:46761
name: dipeptide
namespace: chebi_ontology
alt_id: CHEBI:23835
alt_id: CHEBI:4634
def: "Any molecule that contains two amino-acid residues connected by peptide linkages." []
subset: 3:STAR
synonym: "Dipeptid" RELATED [chebi]
synonym: "Dipeptide" RELATED [kegg.compound]
synonym: "dipeptides" RELATED [chebi]
is_a: CHEBI:25676 ! oligopeptide
relationship: RO:0018036 CHEBI:90799 ! dipeptide zwitterion

[Term]
id: CHEBI:46770
name: pyrrolidinecarboxamide
namespace: chebi_ontology
subset: 3:STAR
synonym: "pyrrolidinecarboxamides" RELATED [chebi]
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:38260 ! pyrrolidines

[Term]
id: CHEBI:46774
name: polyether
namespace: chebi_ontology
def: "Any ether that contains more than one ether linkage." []
subset: 3:STAR
synonym: "polyether" RELATED [chebi]
synonym: "polyethers" RELATED [chebi]
is_a: CHEBI:25698 ! ether

[Term]
id: CHEBI:46786
name: diether
namespace: chebi_ontology
def: "A polyether in which the number of ether linkages is 2." []
subset: 3:STAR
synonym: "diether" RELATED [chebi]
synonym: "diethers" RELATED [chebi]
is_a: CHEBI:46774 ! polyether

[Term]
id: CHEBI:46787
name: solvent
namespace: chebi_ontology
def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." []
subset: 3:STAR
synonym: "Loesungsmittel" RELATED [chebi]
synonym: "solvant" RELATED [chebi]
synonym: "solvents" RELATED [chebi]
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:46812
name: 1,3-oxazoles
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:35790 ! oxazole

[Term]
id: CHEBI:46844
name: N-acylpiperazine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-acylpiperazines" RELATED [chebi]
is_a: CHEBI:26144 ! piperazines
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:46845
name: N-alkylpiperazine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-alkylpiperazines" RELATED [chebi]
is_a: CHEBI:26144 ! piperazines
is_a: CHEBI:50996 ! tertiary amino compound

[Term]
id: CHEBI:46847
name: N-iminopiperazine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-iminopiperazines" RELATED [chebi]
is_a: CHEBI:26144 ! piperazines

[Term]
id: CHEBI:46848
name: N-arylpiperazine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-arylpiperazines" RELATED [chebi]
is_a: CHEBI:26144 ! piperazines
is_a: CHEBI:33860 ! aromatic amine
is_a: CHEBI:50996 ! tertiary amino compound

[Term]
id: CHEBI:46850
name: organoammonium salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "organoammonium salts" RELATED [chebi]
is_a: CHEBI:35276 ! ammonium compound

[Term]
id: CHEBI:46883
name: carboxy group
namespace: chebi_ontology
alt_id: CHEBI:23025
alt_id: CHEBI:41420
subset: 3:STAR
subset: 3_STAR
synonym: "-C(O)OH" RELATED [IUPAC]
synonym: "-C(O)OH" RELATED [iupac]
synonym: "-CO2H" RELATED [ChEBI]
synonym: "-CO2H" RELATED [chebi]
synonym: "-COOH" RELATED [IUPAC]
synonym: "-COOH" RELATED [iupac]
synonym: "CARBOXY GROUP" EXACT [PDBeChem]
synonym: "CARBOXY GROUP" RELATED [pdb-ccd]
synonym: "carboxyl group" RELATED [chebi]
synonym: "carboxyl group" RELATED [ChEBI]
xref: PDBeChem:FMT
is_a: CHEBI:33249 ! organyl group

[Term]
id: CHEBI:46895
name: lipopeptide
namespace: chebi_ontology
def: "A compound consisting of a peptide with attached lipid." []
subset: 3:STAR
synonym: "lipopeptides" RELATED [chebi]
synonym: "LP" RELATED [chebi]
is_a: CHEBI:16670 ! peptide
is_a: CHEBI:18059 ! lipid

[Term]
id: CHEBI:46912
name: ornithinium(1+)
namespace: chebi_ontology
subset: 3:STAR
synonym: "ornithine monocation" RELATED [jcbn]
synonym: "ornithinium(1+)" RELATED [jcbn]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:46913 ! ornithinium(2+)
relationship: RO:0018034 CHEBI:18257 ! ornithine

[Term]
id: CHEBI:46913
name: ornithinium(2+)
namespace: chebi_ontology
subset: 3:STAR
synonym: "ornithine dication" RELATED [jcbn]
synonym: "ornithinium(2+)" RELATED [jcbn]
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: RO:0018034 CHEBI:46912 ! ornithinium(1+)

[Term]
id: CHEBI:46920
name: N-methylpiperazine
namespace: chebi_ontology
subset: 3:STAR
synonym: "N-methylpiperazines" RELATED [chebi]
is_a: CHEBI:46845 ! N-alkylpiperazine

[Term]
id: CHEBI:46942
name: oxanes
namespace: chebi_ontology
def: "Any organic heteromonocyclic compoundthat is oxane or its substituted derivatives." []
subset: 3:STAR
synonym: "tetrahydropyrans" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:46952
name: oxazinane
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxazinanes" RELATED [chebi]
is_a: CHEBI:25693 ! organic heteromonocyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38104 ! oxacycle

[Term]
id: CHEBI:47017
name: tetrahydrofuranol
namespace: chebi_ontology
subset: 3:STAR
synonym: "tetrahydrofuranols" RELATED [chebi]
is_a: CHEBI:26912 ! oxolanes

[Term]
id: CHEBI:47019
name: dihydroxytetrahydrofuran
namespace: chebi_ontology
subset: 3:STAR
synonym: "dihydroxytetrahydrofurans" RELATED [chebi]
is_a: CHEBI:47017 ! tetrahydrofuranol

[Term]
id: CHEBI:471744
name: imipenem
namespace: chebi_ontology
alt_id: CHEBI:5879
def: "A broad-spectrum, intravenous β-lactam antibiotic of the carbapenem subgroup." []
subset: 3:STAR
synonym: "(5R,6S)-3-((2-(Formimidoylamino)ethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid" RELATED [chemidplus]
synonym: "(5R,6S)-3-(2-Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid" RELATED [chembl]
synonym: "(5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure" RELATED [chemidplus]
synonym: "Imipenem" RELATED [kegg.compound]
synonym: "Imipenem anhydrous" RELATED [kegg.compound]
synonym: "imipenemum" RELATED [chemidplus]
synonym: "N-formimidoyl thienamycin" RELATED [patent]
synonym: "N-formimidoylthienamycin" RELATED [chemidplus]
is_a: CHEBI:46633 ! carbapenems
is_a: CHEBI:88225 ! beta-lactam antibiotic allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018036 CHEBI:190509 ! imipenem zwitterion

[Term]
id: CHEBI:472657
name: cefixime
namespace: chebi_ontology
alt_id: CHEBI:3487
def: "A third-generation cephalosporin antibiotic bearing vinyl and (2<i>Z</i>)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections." []
subset: 3:STAR
synonym: "(-)-cefixim" RELATED [chemidplus]
synonym: "(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
is_a: CHEBI:23066 ! cephalosporin
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CHEBI:473992
name: nystatin A1
namespace: chebi_ontology
alt_id: CHEBI:31926
def: "A polyene macrolide antibiotic; part of the nystatin complex produced by several <em>Streptomyces</em> species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species." []
subset: 3:STAR
synonym: "nystatin A1" RELATED [lipidmaps]
is_a: CHEBI:59676 ! nystatins

[Term]
id: CHEBI:474053
name: cefazolin
namespace: chebi_ontology
alt_id: CHEBI:3482
def: "A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1<em>H</em>-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively." []
subset: 3:STAR
synonym: "(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid" RELATED [iupac]
synonym: "Cefamezin" RELATED [chemidplus]
synonym: "Cephamezine" RELATED [chemidplus]
synonym: "Cephazolidin" RELATED [chemidplus]
synonym: "Cephazolin" RELATED [chemidplus]
synonym: "Cephazoline" RELATED [chemidplus]
synonym: "CEZ" RELATED [chebi]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:35689 ! tetrazoles
is_a: CHEBI:38099 ! thiadiazoles
is_a: CHEBI:88225 ! beta-lactam antibiotic allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:53657 ! cefazolin(1-)

[Term]
id: CHEBI:474180
name: caspofungin
namespace: chebi_ontology
alt_id: CHEBI:599509
def: "A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-β-<small>D</small>-glucan, an integral component of the fungal cell wall." []
subset: 3:STAR
synonym: "(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide" RELATED [chemidplus]
synonym: "1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0" RELATED [chebi]
synonym: "Caspofungin" RELATED [chembl]
is_a: CHEBI:24613 ! homodetic cyclic peptide
is_a: CHEBI:57248 ! echinocandin
is_a: CHEBI:72588 ! semisynthetic derivative
is_a: CHEBI:87113 ! antibiotic antifungal drug
relationship: RO:0018038 CHEBI:131609 ! pneumocandin B0

[Term]
id: CHEBI:47518
name: (2S,4R)-ketoconazole
namespace: chebi_ontology
def: "A <i>cis</i>-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1<em>H</em>-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2<i>S</i>,4<i>R</i>)-configuration." []
subset: 3:STAR
synonym: "(2S,4R)-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" RELATED [chebi]
synonym: "(2S,4R)-ketoconazole" RELATED [uniprot_ft]
synonym: "1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE" RELATED [pdb-ccd]
is_a: CHEBI:86411 ! cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
relationship: RO:0018039 CHEBI:48336 ! (2R,4S)-ketoconazole

[Term]
id: CHEBI:47519
name: ketoconazole
namespace: chebi_ontology
alt_id: CHEBI:6126
def: "A racemate consisting of equimolar amounts of (2<i>R</i>,4<i>S</i>)- and (2<i>S</i>,4<i>R</i>)-ketoconazole." []
subset: 3:STAR
synonym: "(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine" RELATED [chemidplus]
synonym: "cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine" RELATED [chemidplus]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87069 ! imidazole antifungal drug
is_a: CHEBI:87071 ! conazole antifungal drug
relationship: BFO:0000051 CHEBI:47518 ! has part (2S,4R)-ketoconazole
relationship: BFO:0000051 CHEBI:48336 ! has part (2R,4S)-ketoconazole

[Term]
id: CHEBI:47724
name: vancomycin aglycone
namespace: chebi_ontology
def: "A peptide antibiotic that is vancomycin lacking the disaccharide moiety." []
subset: 3:STAR
synonym: "Aglucovancomycin B" RELATED [chemidplus]
synonym: "Balhimycin aglycon" RELATED [chemidplus]
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:25903 ! peptide antibiotic
is_a: CHEBI:26195 ! polyphenol
is_a: CHEBI:37407 ! cyclic ether
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0018034 CHEBI:77981 ! vancomycin aglycone(1-)
relationship: RO:0018036 CHEBI:75954 ! vancomycin aglycone zwitterion

[Term]
id: CHEBI:47779
name: aminoglycoside
namespace: chebi_ontology
subset: 3:STAR
synonym: "aminoglycosides" RELATED [chebi]
is_a: CHEBI:24400 ! glycoside

[Term]
id: CHEBI:47811
name: penamcarboxylate
namespace: chebi_ontology
subset: 3:STAR
synonym: "penamcarboxylates" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
is_a: CHEBI:35992 ! penams

[Term]
id: CHEBI:478164
name: cefepime
namespace: chebi_ontology
alt_id: CHEBI:3486
alt_id: CHEBI:473919
def: "A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2<i>Z</i>)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton." []
subset: 3:STAR
synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [iupac]
synonym: "Cefepime" RELATED [kegg.compound]
synonym: "cefepime" RELATED [chembl]
synonym: "CFPM" RELATED [chebi]
is_a: CHEBI:23066 ! cephalosporin
is_a: CHEBI:36816 ! oxime O-ether
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018033 CHEBI:59349 ! cefepime(1+)

[Term]
id: CHEBI:47857
name: ureas
namespace: chebi_ontology
alt_id: CHEBI:27220
alt_id: CHEBI:36947
subset: 3:STAR
synonym: "urea derivatives" RELATED [chebi]
is_a: CHEBI:33256 ! primary amide
relationship: RO:0018038 CHEBI:16199 ! urea

[Term]
id: CHEBI:47867
name: indicator
namespace: chebi_ontology
def: "Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc." []
subset: 3:STAR
synonym: "Indikator" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:47880
name: steroid ester
namespace: chebi_ontology
alt_id: CHEBI:26762
subset: 3:STAR
synonym: "steroid esters" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:35701 ! ester

[Term]
id: CHEBI:47881
name: 3-oxo monocarboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:13600
alt_id: CHEBI:1619
alt_id: CHEBI:35949
subset: 3:STAR
synonym: "3-Keto acid" RELATED [kegg.compound]
synonym: "3-Oxo acid" RELATED [kegg.compound]
synonym: "3-oxo monocarboxylic acids" RELATED [chebi]
synonym: "3-oxomonocarboxylic acid" RELATED [chebi]
synonym: "3-oxomonocarboxylic acids" RELATED [chebi]
is_a: CHEBI:35871 ! oxo monocarboxylic acid
relationship: RO:0018034 CHEBI:35973 ! 3-oxo monocarboxylic acid anion

[Term]
id: CHEBI:47891
name: steroid acid
namespace: chebi_ontology
def: "Any steroid substituted by at least one carboxy group." []
subset: 3:STAR
synonym: "steroid acids" RELATED [chebi]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:64709 ! organic acid
relationship: RO:0018034 CHEBI:50160 ! steroid acid anion

[Term]
id: CHEBI:47956
name: thiocarboxamide
namespace: chebi_ontology
def: "Any primary amide having its amide oxygen replaced by sulfur." []
subset: 3:STAR
synonym: "thioamide" RELATED [chebi]
synonym: "thiocarboxamides" RELATED [chebi]
synonym: "thionoamide" RELATED [chebi]
is_a: CHEBI:33256 ! primary amide

[Term]
id: CHEBI:47985
name: enol ether
namespace: chebi_ontology
def: "Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage." []
subset: 3:STAR
synonym: "enol ether" RELATED [chebi]
synonym: "enol ethers" RELATED [chebi]
is_a: CHEBI:25698 ! ether
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:48001
name: protein synthesis inhibitor
namespace: chebi_ontology
def: "A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein." []
subset: 3:STAR
synonym: "protein synthesis antagonist" RELATED [chebi]
synonym: "protein synthesis antagonists" RELATED [chebi]
synonym: "protein synthesis inhibitors" RELATED [chebi]
is_a: CHEBI:76932 ! pathway inhibitor

[Term]
id: CHEBI:48080
name: brefeldin A
namespace: chebi_ontology
def: "A metabolite from <em>Penicillium brefeldianum</em> that exhibits a wide range of antibiotic activity." []
subset: 3:STAR
synonym: "ascotoxin" RELATED [chemidplus]
synonym: "Brefeldin A" RELATED [chemidplus]
synonym: "cyanein" RELATED [chemidplus]
synonym: "decumbin" RELATED [chemidplus]
is_a: CHEBI:25105 ! macrolide antibiotic
relationship: RO:0000087 CHEBI:76964 ! has role Penicillium metabolite

[Term]
id: CHEBI:4811
name: epoxiconazole
namespace: chebi_ontology
def: "A racemate composed of equimolar amounts of (2<i>S</i>,3<i>R</i>)- and (2<i>R</i>,3<i>S</i>)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by <em>Ascomycetes</em>, <em>Basidiomycetes</em> and <em>Deuteromycetes</em>. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms." []
subset: 3:STAR
synonym: "(2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4-fluorophenyl)propyl]-1H-1,2,4-triazole" RELATED [pesticides]
synonym: "rel-1-[[(2R,3S)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-2-oxiranyl]methyl]-1H-1,2,4-triazole" RELATED [pesticides]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: BFO:0000051 CHEBI:83759 ! has part (2S,3R)-epoxiconazole
relationship: BFO:0000051 CHEBI:83761 ! has part (2R,3S)-epoxiconazole
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:48121
name: polyene
namespace: chebi_ontology
def: "An olefin that contains more than one carbon-carbon double bond." []
subset: 3:STAR
synonym: "polyenes" RELATED [chebi]
is_a: CHEBI:33641 ! olefin

[Term]
id: CHEBI:48132
name: tetracenomycin
namespace: chebi_ontology
def: "A polyketide based on a tetracene ring structure." []
subset: 3:STAR
synonym: "tetracenomycins" RELATED [chebi]
is_a: CHEBI:26188 ! polyketide
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:48154
name: sulfur oxide
namespace: chebi_ontology
subset: 3:STAR
synonym: "oxides of sulfur" RELATED [chebi]
synonym: "Schwefeloxide" RELATED [chebi]
synonym: "sulfur oxides" RELATED [chebi]
is_a: CHEBI:24836 ! inorganic oxide
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:48219
name: disinfectant
namespace: chebi_ontology
def: "An antimicrobial agent that is applied to non-living objects to destroy harmful microorganisms or to inhibit their activity." []
subset: 3:STAR
synonym: "desinfectant" RELATED [chebi]
synonym: "Desinfektionsmittel" RELATED [chebi]
synonym: "disinfectants" RELATED [chebi]
synonym: "disinfecting agent" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent

[Term]
id: CHEBI:48336
name: (2R,4S)-ketoconazole
namespace: chebi_ontology
def: "A <i>cis</i>-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1<em>H</em>-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2<i>R</i>,4<i>S</i>)-configuration." []
subset: 3:STAR
synonym: "(2R,4S)-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine" RELATED [chebi]
synonym: "(2R,4S)-ketoconazole" RELATED [uniprot_ft]
is_a: CHEBI:86411 ! cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
relationship: RO:0018039 CHEBI:47518 ! (2S,4R)-ketoconazole

[Term]
id: CHEBI:48339
name: 1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine
namespace: chebi_ontology
def: "A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [<em>para</em>-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively." []
subset: 3:STAR
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:24780 ! imidazoles
is_a: CHEBI:25698 ! ether
is_a: CHEBI:39430 ! dioxolane
is_a: CHEBI:46844 ! N-acylpiperazine
is_a: CHEBI:46848 ! N-arylpiperazine

[Term]
id: CHEBI:48343
name: disulfide
namespace: chebi_ontology
def: "Compounds of structure RSSR'." []
subset: 3:STAR
synonym: "disulfides" RELATED [chebi]
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:48354
name: polar solvent
namespace: chebi_ontology
def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." []
subset: 3:STAR
synonym: "polar solvents" RELATED [chebi]
is_a: CHEBI:46787 ! solvent

[Term]
id: CHEBI:48355
name: non-polar solvent
namespace: chebi_ontology
subset: 1:STAR
synonym: "non-polar solvents" RELATED [chebi]
is_a: CHEBI:46787 ! solvent

[Term]
id: CHEBI:48356
name: protic solvent
namespace: chebi_ontology
def: "A polar solvent that is capable of acting as a hydron (proton) donor." []
subset: 3:STAR
is_a: CHEBI:39141 ! Bronsted acid
is_a: CHEBI:48354 ! polar solvent

[Term]
id: CHEBI:48359
name: protophilic solvent
namespace: chebi_ontology
def: "Solvent that is capable of acting as a hydron (proton) acceptor." []
subset: 3:STAR
synonym: "HBA solvent" RELATED [chebi]
synonym: "hydrogen bond acceptor solvent" RELATED [chebi]
is_a: CHEBI:39142 ! Bronsted base
is_a: CHEBI:48354 ! polar solvent

[Term]
id: CHEBI:48360
name: amphiprotic solvent
namespace: chebi_ontology
def: "Self-ionizing solvent possessing both characteristics of Brønsted acids and bases." []
subset: 3:STAR
is_a: CHEBI:48356 ! protic solvent
is_a: CHEBI:48359 ! protophilic solvent

[Term]
id: CHEBI:48376
name: carbamimidic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "carbamimic acid" RELATED [chemidplus]
synonym: "carbonamidimidic acid" RELATED [iupac]
synonym: "H2N-C(=NH)-OH" RELATED [iupac]
synonym: "H2N-C(OH)=NH" RELATED [iupac]
synonym: "HO-C(=NH)-NH2" RELATED [iupac]
synonym: "Isoharnstoff" RELATED [chebi]
synonym: "isourea" RELATED [chemidplus]
synonym: "pseudourea" RELATED [chemidplus]
is_a: CHEBI:48379 ! isourea
is_a: CHEBI:64708 ! one-carbon compound
relationship: RO:0018036 CHEBI:16199 ! urea

[Term]
id: CHEBI:48377
name: imidic acid
namespace: chebi_ontology
def: "Compounds derived from oxoacids R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH)." []
subset: 3:STAR
synonym: "imidic acid" RELATED [chebi]
synonym: "imidic acids" RELATED [chebi]
synonym: "imino acids" RELATED [iupac]
is_a: CHEBI:33241 ! oxoacid derivative
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:48378
name: carboximidic acid
namespace: chebi_ontology
subset: 3:STAR
synonym: "carboximidic acid" RELATED [chebi]
synonym: "carboximidic acids" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:48377 ! imidic acid

[Term]
id: CHEBI:48379
name: isourea
namespace: chebi_ontology
def: "A carboximidic acid that is the imidic acid tautomer of urea, H<small><sub>2</sub></small>NC(=NH)OH, and its hydrocarbyl derivatives." []
subset: 3:STAR
synonym: "isoureas" RELATED [chebi]
is_a: CHEBI:48378 ! carboximidic acid

[Term]
id: CHEBI:48422
name: angiogenesis inhibitor
namespace: chebi_ontology
alt_id: CHEBI:67170
def: "An agent and endogenous substances that antagonize or inhibit the development of new blood vessels." []
subset: 3:STAR
synonym: "angiogenesis antagonist" RELATED [chebi]
synonym: "angiostatic agents" RELATED [chebi]
synonym: "anti-angiogenic agent" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:48535
name: aryloxypyrimidine
namespace: chebi_ontology
subset: 3:STAR
synonym: "aryloxypyrimidines" RELATED [chebi]
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:39447 ! pyrimidines

[Term]
id: CHEBI:48589
name: piperidones
namespace: chebi_ontology
subset: 3:STAR
synonym: "piperidone" RELATED [chebi]
is_a: CHEBI:26151 ! piperidines
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:48626
name: pyranoindolizinoquinoline
namespace: chebi_ontology
subset: 3:STAR
synonym: "pyranoindolizinoquinolines" RELATED [chebi]
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:38164 ! organic heteropentacyclic compound

[Term]
id: CHEBI:48705
name: agonist
namespace: chebi_ontology
def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." []
subset: 3:STAR
synonym: "agonista" RELATED [chebi]
synonym: "agoniste" RELATED [chebi]
synonym: "agonists" RELATED [chebi]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:48706
name: antagonist
namespace: chebi_ontology
def: "Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances." []
subset: 3:STAR
synonym: "antagonista" RELATED [chebi]
synonym: "antagoniste" RELATED [chebi]
synonym: "antagonists" RELATED [chebi]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:4877
name: ethambutol
namespace: chebi_ontology
alt_id: CHEBI:133410
alt_id: CHEBI:659237
alt_id: CHEBI:678172
def: "An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (<i>S</i>,<i>S</i>-configuration). It is a bacteriostatic antimycobacterial drug, effective against <em>Mycobacterium tuberculosis</em> and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of <em>M. tuberculosis</em> are readily produced if ethambutol is used alone." []
subset: 3:STAR
synonym: "(+)-2,2'-(ethylenediimino)di-1-butanol" RELATED [chemidplus]
synonym: "(+)-ethambutol" RELATED [chebi]
synonym: "(+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine" RELATED [chemidplus]
synonym: "(+)-S,S-ethambutol" RELATED [chemidplus]
synonym: "(2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol" RELATED [chebi]
synonym: "(S,S)-ethambutol" RELATED [chebi]
synonym: "EMB" RELATED [chebi]
synonym: "Ethambutol" RELATED [kegg.compound]
synonym: "S,S-Ethambutol" RELATED [chembl]
is_a: CHEBI:23981 ! ethanolamines
is_a: CHEBI:31577 ! ethylenediamine derivative
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant

[Term]
id: CHEBI:48819
name: cyano group
namespace: chebi_ontology
alt_id: CHEBI:36824
alt_id: CHEBI:48818
subset: 3:STAR
synonym: "-C#N" RELATED [iupac]
synonym: "-CN" RELATED [iupac]
synonym: "carbonitrile group" RELATED [chebi]
synonym: "CYANIDE GROUP" RELATED [pdb-ccd]
synonym: "NC-" RELATED [iupac]
is_a: CHEBI:36823 ! pseudohalo group
relationship: RO:0018037 CHEBI:18407 ! hydrogen cyanide

[Term]
id: CHEBI:48848
name: erythronolide A
namespace: chebi_ontology
subset: 3:STAR
synonym: "Erythronolid A" RELATED [chebi]
is_a: CHEBI:23955 ! erythronolide

[Term]
id: CHEBI:4885
name: ethionamide
namespace: chebi_ontology
def: "A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding <em>S</em>-oxide." []
subset: 3:STAR
synonym: "2-ethyl-4-thiopyridylamide" RELATED [chebi]
synonym: "ETH" RELATED [drugbank]
synonym: "Ethinamide" RELATED [drugbank]
synonym: "Ethionamide" RELATED [kegg.compound]
synonym: "ethionamide" RELATED [uniprot_ft]
synonym: "Ethioniamide" RELATED [drugbank]
synonym: "Ethylisothiamide" RELATED [drugbank]
synonym: "Ethyonomide" RELATED [drugbank]
synonym: "Etionamid" RELATED [drugbank]
synonym: "Etionamide" RELATED [drugbank]
synonym: "Etioniamid" RELATED [drugbank]
synonym: "ETP" RELATED [drugbank]
is_a: CHEBI:26421 ! pyridines
is_a: CHEBI:47956 ! thiocarboxamide
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0000087 CHEBI:35679 ! has role antilipemic drug
relationship: RO:0000087 CHEBI:35816 ! has role leprostatic drug
relationship: RO:0000087 CHEBI:50185 ! has role fatty acid synthesis inhibitor
relationship: RO:0000087 CHEBI:50266 ! has role prodrug

[Term]
id: CHEBI:48854
name: sulfurous acid
namespace: chebi_ontology
alt_id: CHEBI:26837
alt_id: CHEBI:9344
subset: 3:STAR
synonym: "[SO(OH)2]" RELATED [iupac]
synonym: "acide sulfureux" RELATED [chebi]
synonym: "acido sulfuroso" RELATED [chebi]
synonym: "H2SO3" RELATED [iupac]
synonym: "S(O)(OH)2" RELATED [iupac]
synonym: "schweflige Saeure" RELATED [chemidplus]
synonym: "Sulfite" EXACT [KEGG_COMPOUND]
synonym: "Sulfite" RELATED [kegg.compound]
synonym: "Sulfurous acid" RELATED [kegg.compound]
synonym: "sulphurous acid" RELATED [chemidplus]
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: RO:0018034 CHEBI:17137 ! hydrogensulfite
relationship: RO:0018036 CHEBI:29214 ! sulfonic acid

[Term]
id: CHEBI:48891
name: thiazolidinone
namespace: chebi_ontology
subset: 3:STAR
synonym: "thiazolidinones" RELATED [chebi]
is_a: CHEBI:35622 ! thiazolidines

[Term]
id: CHEBI:48901
name: thiazoles
namespace: chebi_ontology
def: "An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom." []
subset: 3:STAR
synonym: "thiazole" RELATED [chebi]
is_a: CHEBI:38106 ! organosulfur heterocyclic compound
is_a: CHEBI:68452 ! azole

[Term]
id: CHEBI:48908
name: triazolobenzothiazole
namespace: chebi_ontology
subset: 3:STAR
synonym: "triazolobenzothiazoles" RELATED [chebi]
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38106 ! organosulfur heterocyclic compound

[Term]
id: CHEBI:48923
name: erythromycin
namespace: chebi_ontology
def: "Any of several wide-spectrum macrolide antibiotics obtained from actinomycete <em>Saccharopolyspora erythraea</em> (formerly known as <em>Streptomyces erythraeus</em>)." []
subset: 3:STAR
synonym: "eritromicina" RELATED [chebi]
synonym: "erthromycin" RELATED [chebi]
synonym: "erythromycine" RELATED [chebi]
is_a: CHEBI:23953 ! erythromycins
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0018034 CHEBI:64290 ! erythromycin cation

[Term]
id: CHEBI:48960
name: bis(azo) compound
namespace: chebi_ontology
def: "Any  azo compound containing two ‒N=N‒ groups." []
subset: 3:STAR
synonym: "bis(azo) compounds" RELATED [chebi]
is_a: CHEBI:37533 ! azo compound

[Term]
id: CHEBI:48975
name: substituted aniline
namespace: chebi_ontology
subset: 3:STAR
synonym: "substituted anilines" RELATED [chebi]
is_a: CHEBI:22562 ! anilines

[Term]
id: CHEBI:49020
name: hormone antagonist
namespace: chebi_ontology
def: "A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." []
subset: 3:STAR
synonym: "hormone antagonists" RELATED [chebi]
is_a: CHEBI:48706 ! antagonist
is_a: CHEBI:51061 ! hormone receptor modulator

[Term]
id: CHEBI:49103
name: drug metabolite
namespace: chebi_ontology
subset: 3:STAR
synonym: "drug metabolites" RELATED [chebi]
is_a: CHEBI:76967 ! human xenobiotic metabolite

[Term]
id: CHEBI:49167
name: anti-asthmatic drug
namespace: chebi_ontology
def: "A drug used to treat asthma." []
subset: 3:STAR
synonym: "anti-asthmatic agent" RELATED [chebi]
synonym: "anti-asthmatic agents" RELATED [chebi]
synonym: "anti-asthmatic drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:65023 ! anti-asthmatic agent

[Term]
id: CHEBI:49318
name: piperidine antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "piperidine antibiotics" RELATED [chebi]
is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic
is_a: CHEBI:26151 ! piperidines

[Term]
id: CHEBI:49319
name: carbocyclic antibiotic
namespace: chebi_ontology
subset: 1:STAR
synonym: "carbocyclic antibiotics" RELATED [chebi]
is_a: CHEBI:33598 ! carbocyclic compound
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:49637
name: hydrogen atom
namespace: chebi_ontology
alt_id: CHEBI:24634
alt_id: CHEBI:49636
subset: 3:STAR
subset: 3_STAR
synonym: "1H" RELATED [IUPAC]
synonym: "1H" RELATED [iupac]
synonym: "H" RELATED [iupac]
synonym: "H" RELATED [IUPAC]
synonym: "hidrogeno" RELATED [ChEBI]
synonym: "hidrogeno" RELATED [chebi]
synonym: "hydrogen" RELATED [chebi]
synonym: "hydrogen" RELATED [ChEBI]
synonym: "hydrogene" RELATED [chebi]
synonym: "hydrogene" RELATED [ChEBI]
synonym: "Wasserstoff" RELATED [chebi]
synonym: "Wasserstoff" RELATED [ChEBI]
xref: WebElements:H
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33559 ! s-block element atom
relationship: RO:0000087 CHEBI:33937 ! has role macronutrient

[Term]
id: CHEBI:4998
name: fenarimol
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union." []
subset: 3:STAR
synonym: "(+-)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol" RELATED [chemidplus]
synonym: "(+-)-fenarimol" RELATED [hmdb]
synonym: "(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol" RELATED [nist]
synonym: "(RS)-2,4'-dichloro-alpha-(pyrimidin-5-yl)benzhydryl alcohol" RELATED [pesticides]
synonym: "2,4'-dichloro-alpha(pyrimidin-5-yl)benzhydryl alcohol" RELATED [nist]
synonym: "alpha-(2-chlorophenyl)-alpha-(4-chlorophenyl)-5-pyrimidinemethanol" RELATED [pesticides]
synonym: "fenarimol" RELATED [chebi]
synonym: "rac-(R)-(2-chlorophenyl)(4-chlorophenyl)(pyrimidin-5-yl)methanol" RELATED [pesticides]
synonym: "rac-fenarimol" RELATED [chebi]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87207 ! pyrimidine fungicide
relationship: BFO:0000051 CHEBI:83688 ! has part (R)-fenarimol
relationship: BFO:0000051 CHEBI:83689 ! has part (S)-fenarimol
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:50010
name: 4,4'-bis(\{4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl\}amino)stilbene-2,2'-disulfonic acid
namespace: chebi_ontology
def: "An organosulfonic acid comprising stilbene having 4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino groups at the 4 and 4'-positions and sulfo groups at the 2- and 2'-positions." []
subset: 3:STAR
synonym: "4,4'-bis((4-(bis(2-hydroxyethyl)amino)-6-anilino-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonic acid" RELATED [chemidplus]
synonym: "4,4'-bis((4-anilino-6-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulfonic acid" RELATED [chemidplus]
synonym: "4,4'-bis((4-anilino-6-(bis(2-hydroxyethyl)amino)-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid" RELATED [chemidplus]
synonym: "C.I. Fluorescent brightening agent 28" RELATED [chemidplus]
synonym: "Calcofluor M2R" RELATED [chemidplus]
synonym: "Calcofluor White M2R" RELATED [chemidplus]
is_a: CHEBI:26588 ! 1,3,5-triazines
is_a: CHEBI:33551 ! organosulfonic acid
relationship: RO:0000087 CHEBI:51217 ! has role fluorochrome
relationship: RO:0018034 CHEBI:50012 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonate
relationship: RO:0018040 CHEBI:26775 ! stilbene

[Term]
id: CHEBI:50011
name: Calcofluor White
namespace: chebi_ontology
subset: 3:STAR
synonym: "4,4'-bis((2-anilino-4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-6-yl)amino)stilbene-2,2'-disulfonic acid, disodium salt" RELATED [chemidplus]
synonym: "4,4'-bis((4-anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid, disodium salt" RELATED [chemidplus]
synonym: "C.I. 40622" RELATED [chebi]
synonym: "C.I. Fluorescent Brightening Agent 28, disodium salt" RELATED [chemidplus]
synonym: "Calcofluor White LRP" RELATED [chemidplus]
synonym: "Calcofluor White M 2R" RELATED [chemidplus]
synonym: "Calcofluor White ST" RELATED [chemidplus]
synonym: "Cellufluor" RELATED [chemidplus]
synonym: "disodium 4,4'-bis(6-anilino-(4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonate" RELATED [chemidplus]
synonym: "Fluorescent Brightener 28" RELATED [chemidplus]
is_a: CHEBI:38700 ! organic sodium salt
relationship: BFO:0000051 CHEBI:50012 ! has part 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonate

[Term]
id: CHEBI:50012
name: 4,4'-bis(\{4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl\}amino)stilbene-2,2'-disulfonate
namespace: chebi_ontology
def: "An arenesulfonate arising from deprotonation of the sulfo groups of 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonic acid." []
subset: 3:STAR
is_a: CHEBI:22713 ! arenesulfonate oxoanion
relationship: RO:0018033 CHEBI:50010 ! 4,4'-bis({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)stilbene-2,2'-disulfonic acid
relationship: RO:0018040 CHEBI:26775 ! stilbene

[Term]
id: CHEBI:50047
name: organic amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic amino compounds" RELATED [chebi]
synonym: "organic amino compounds" RELATED [ChEBI]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: has_parent_hydride CHEBI:16134 ! ammonia
relationship: RO:0000087 CHEBI:39142 ! has role Bronsted base
relationship: RO:0018040 CHEBI:16134 ! ammonia

[Term]
id: CHEBI:50103
name: excitatory amino acid agonist
namespace: chebi_ontology
def: "An agent that binds to and activates excitatory amino acid receptors." []
subset: 3:STAR
synonym: "excitatory amino acid agonists" RELATED [chebi]
synonym: "excitatory amino acid receptor agonist" RELATED [chebi]
synonym: "excitatory amino acid receptor agonists" RELATED [chebi]
is_a: CHEBI:35942 ! neurotransmitter agent

[Term]
id: CHEBI:50160
name: steroid acid anion
namespace: chebi_ontology
def: "Any anion formed by loss of a proton from a steroid acid." []
subset: 3:STAR
synonym: "steroid acid anions" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:47891 ! steroid acid

[Term]
id: CHEBI:50176
name: keratolytic drug
namespace: chebi_ontology
def: "A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases." []
subset: 3:STAR
synonym: "desquamating agent" RELATED [chebi]
synonym: "keratolytic agent" RELATED [chebi]
synonym: "keratolytic drugs" RELATED [chebi]
synonym: "skin-peeling agent" RELATED [chebi]
is_a: CHEBI:50177 ! dermatologic drug

[Term]
id: CHEBI:50177
name: dermatologic drug
namespace: chebi_ontology
def: "A drug used to treat or prevent skin disorders or for the routine care of skin." []
subset: 3:STAR
synonym: "dermatologic agent" RELATED [chebi]
synonym: "dermatologic drugs" RELATED [chebi]
synonym: "dermatological agent" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50183
name: P450 inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances." []
subset: 3:STAR
synonym: "CYP2D6 inhibitor" RELATED [chebi]
synonym: "CYP2D6 inhibitors" RELATED [chebi]
synonym: "cytochrome P450 inhibitor" RELATED [chebi]
synonym: "cytochrome P450 inhibitors" RELATED [chebi]
synonym: "P450 inhibitors" RELATED [chebi]
is_a: CHEBI:76898 ! EC 1.14.14.1 (unspecific monooxygenase) inhibitor

[Term]
id: CHEBI:50185
name: fatty acid synthesis inhibitor
namespace: chebi_ontology
def: "Any pathway inhibitor that inhibits the synthesis of fatty acids." []
subset: 3:STAR
synonym: "fatty acid synthesis inhibitors" RELATED [chebi]
is_a: CHEBI:76932 ! pathway inhibitor

[Term]
id: CHEBI:50247
name: antidote
namespace: chebi_ontology
def: "Any protective agent counteracting or neutralizing the action of poisons." []
subset: 3:STAR
synonym: "antidotes" RELATED [chebi]
is_a: CHEBI:50267 ! protective agent

[Term]
id: CHEBI:50248
name: hematologic agent
namespace: chebi_ontology
def: "Drug that acts on blood and blood-forming organs and those that affect the hemostatic system." []
subset: 3:STAR
synonym: "hematologic agents" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50249
name: anticoagulant
namespace: chebi_ontology
def: "An agent that prevents blood clotting." []
subset: 3:STAR
synonym: "anticoagulante" RELATED [chebi]
synonym: "anticoagulants" RELATED [chebi]
is_a: CHEBI:50248 ! hematologic agent

[Term]
id: CHEBI:50266
name: prodrug
namespace: chebi_ontology
def: "A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug." []
subset: 3:STAR
synonym: "Prodrugs" RELATED [chebi]
is_a: CHEBI:136859 ! pro-agent
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50267
name: protective agent
namespace: chebi_ontology
def: "Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent." []
subset: 3:STAR
synonym: "chemoprotectant" RELATED [chebi]
synonym: "chemoprotectants" RELATED [chebi]
synonym: "chemoprotective agent" RELATED [chebi]
synonym: "chemoprotective agents" RELATED [chebi]
synonym: "protective agents" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50276
name: EC 5.99.1.2 (DNA topoisomerase) inhibitor
namespace: chebi_ontology
def: "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." []
subset: 3:STAR
synonym: "DNA topoisomerase inhibitor" RELATED [chebi]
synonym: "DNA topoisomerase inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.2 (DNA topoisomerase) inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.2 (topoisomerase I) inhibitor" RELATED [chebi]
synonym: "EC 5.99.1.2 (topoisomerase I) inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.2 inhibitor" RELATED [chebi]
synonym: "EC 5.99.1.2 inhibitors" RELATED [chebi]
synonym: "topoisomerase I (EC 5.99.1.2) inhibitor" RELATED [chebi]
synonym: "topoisomerase I (EC 5.99.1.2) inhibitors" RELATED [chebi]
synonym: "topoisomerase I inhibitor" RELATED [chebi]
synonym: "topoisomerase I inhibitors" RELATED [chebi]
synonym: "type I DNA topoisomerase inhibitor" RELATED [chebi]
synonym: "type I DNA topoisomerase inhibitors" RELATED [chebi]
is_a: CHEBI:70727 ! topoisomerase inhibitor

[Term]
id: CHEBI:50297
name: canonical nucleotide residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "canonical nucleotide residues" RELATED [chebi]
synonym: "canonical nucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50319 ! nucleotide residue

[Term]
id: CHEBI:50299
name: canonical ribonucleotide residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "canonical ribonucleotide residues" RELATED [chebi]
synonym: "canonical ribonucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50297 ! canonical nucleotide residue

[Term]
id: CHEBI:50312
name: onium compound
namespace: chebi_ontology
subset: 1:STAR
subset: 1_STAR
synonym: "onium compound" RELATED [chebi]
synonym: "onium compounds" RELATED [chebi]
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:50313
name: onium cation
namespace: chebi_ontology
def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." []
subset: 3:STAR
subset: 3_STAR
synonym: "onium cations" RELATED [ChEBI]
synonym: "onium cations" RELATED [chebi]
synonym: "onium ion" RELATED [ChEBI]
synonym: "onium ion" RELATED [chebi]
synonym: "onium ions" RELATED [ChEBI]
synonym: "onium ions" RELATED [chebi]
is_a: CHEBI:50312 ! onium compound

[Term]
id: CHEBI:50315
name: chloronium
namespace: chebi_ontology
subset: 3:STAR
synonym: "[ClH2](+)" RELATED [iupac]
synonym: "H2Cl(+)" RELATED [iupac]
is_a: CHEBI:50313 ! onium cation
relationship: RO:0018034 CHEBI:17883 ! hydrogen chloride

[Term]
id: CHEBI:50319
name: nucleotide residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "nucleotide residues" RELATED [chebi]
synonym: "nucleotide residues" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:50320
name: nucleoside residue
namespace: chebi_ontology
subset: 3:STAR
subset: 3_STAR
synonym: "nucleoside residues" RELATED [chebi]
synonym: "nucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:50325
name: proteinogenic amino-acid side-chain group
namespace: chebi_ontology
def: "A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid." []
subset: 3:STAR
synonym: "canonical amino-acid side-chain" RELATED [chebi]
synonym: "canonical amino-acid side-chains" RELATED [chebi]
synonym: "proteinogenic amino-acid side-chain" RELATED [chebi]
synonym: "proteinogenic amino-acid side-chain groups" RELATED [chebi]
synonym: "proteinogenic amino-acid side-chains" RELATED [chebi]
is_a: CHEBI:33249 ! organyl group

[Term]
id: CHEBI:50335
name: organic nitrogen anion
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic nitrogen anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:50344
name: avermectin
namespace: chebi_ontology
def: "Any of the macrolides obtained as fermentation products from the bacterium <em>Streptomyces avermitilis</em> and consisting of a 16-membered macrocyclic backbone that is fused both benzofuran and spiroketal functions and contains a disaccharide substituent. They have significant anthelmintic and insecticidal properties." []
subset: 3:STAR
synonym: "avermectin" RELATED [chebi]
synonym: "avermectins" RELATED [chebi]
is_a: CHEBI:25106 ! macrolide
is_a: CHEBI:59779 ! cyclic ketal
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:50346
name: emamectins
namespace: chebi_ontology
subset: 3:STAR
synonym: "emamectin" RELATED [chebi]
is_a: CHEBI:25106 ! macrolide
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:50406
name: probe
namespace: chebi_ontology
def: "A role played by a molecular entity used to study the microscopic environment." []
subset: 3:STAR
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:50471
name: primary arylamine
namespace: chebi_ontology
def: "A primary amine formally derived from ammonia by replacing one hydrogen atom by an aryl group. R-NH<small><sub>2</sub></small> where R is an aryl group." []
subset: 3:STAR
synonym: "an arylamine" RELATED [uniprot_ft]
synonym: "primary arylamine" RELATED [chebi]
is_a: CHEBI:32877 ! primary amine
is_a: CHEBI:33860 ! aromatic amine

[Term]
id: CHEBI:50492
name: thiocarbonyl compound
namespace: chebi_ontology
def: "Any compound containing the thiocarbonyl group, C=S." []
subset: 3:STAR
synonym: "thiocarbonyl compounds" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound
relationship: BFO:0000051 CHEBI:30256 ! has part thiocarbonyl group

[Term]
id: CHEBI:50525
name: phenolate anion
namespace: chebi_ontology
def: "An organic anion arising from deprotonation of the OH function of a phenol compound." []
subset: 3:STAR
synonym: "phenolate anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion

[Term]
id: CHEBI:50533
name: protein denaturant
namespace: chebi_ontology
subset: 1:STAR
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:50584
name: alkyl alcohol
namespace: chebi_ontology
alt_id: CHEBI:22937
alt_id: CHEBI:50581
def: "An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position." []
subset: 3:STAR
synonym: "alkyl alcohols" RELATED [chebi]
synonym: "hydroxyalkane" RELATED [chebi]
synonym: "hydroxyalkanes" RELATED [chebi]
is_a: CHEBI:2571 ! aliphatic alcohol

[Term]
id: CHEBI:50635
name: EC 3.5.1.5 (urease) inhibitor
namespace: chebi_ontology
def: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the activity of urease (EC 3.5.1.5), reducing hydrolysis." []
subset: 3:STAR
synonym: "EC 3.5.1.5 (urease) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.5 inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.5 inhibitors" RELATED [chebi]
synonym: "urea amidohydrolase inhibitor" RELATED [chebi]
synonym: "urea amidohydrolase inhibitors" RELATED [chebi]
synonym: "urease (EC 3.5.1.5) inhibitor" RELATED [chebi]
synonym: "urease (EC 3.5.1.5) inhibitors" RELATED [chebi]
synonym: "urease inhibitor" RELATED [chebi]
synonym: "urease inhibitors" RELATED [chebi]
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:50658
name: ampicillin(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
synonym: "ampicillinate" RELATED [chebi]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:28971 ! ampicillin

[Term]
id: CHEBI:50683
name: EC 1.5.1.3 (dihydrofolate reductase) inhibitor
namespace: chebi_ontology
def: "An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3)." []
subset: 3:STAR
synonym: "7,8-dihydrofolate reductase inhibitor" RELATED [chebi]
synonym: "7,8-dihydrofolate reductase inhibitors" RELATED [chebi]
synonym: "DHFR inhibitor" RELATED [chebi]
synonym: "DHFR inhibitors" RELATED [chebi]
synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitor" RELATED [chebi]
synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitors" RELATED [chebi]
synonym: "dihydrofolate reductase inhibitor" RELATED [chebi]
synonym: "dihydrofolate reductase inhibitors" RELATED [chebi]
synonym: "dihydrofolic acid reductase inhibitor" RELATED [chebi]
synonym: "dihydrofolic acid reductase inhibitors" RELATED [chebi]
synonym: "dihydrofolic reductase inhibitor" RELATED [chebi]
synonym: "dihydrofolic reductase inhibitors" RELATED [chebi]
synonym: "EC 1.5.1.3 (dihydrofolate reductase) inhibitors" RELATED [chebi]
synonym: "EC 1.5.1.3 inhibitor" RELATED [chebi]
synonym: "EC 1.5.1.3 inhibitors" RELATED [chebi]
synonym: "folic acid reductase inhibitor" RELATED [chebi]
synonym: "folic acid reductase inhibitors" RELATED [chebi]
synonym: "folic reductase inhibitor" RELATED [chebi]
synonym: "folic reductase inhibitors" RELATED [chebi]
synonym: "NADPH-dihydrofolate reductase inhibitor" RELATED [chebi]
synonym: "NADPH-dihydrofolate reductase inhibitors" RELATED [chebi]
synonym: "tetrahydrofolate dehydrogenase inhibitor" RELATED [chebi]
synonym: "tetrahydrofolate dehydrogenase inhibitors" RELATED [chebi]
is_a: CHEBI:73913 ! antifolate
is_a: CHEBI:76863 ! EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor

[Term]
id: CHEBI:50685
name: antitrichomonal drug
namespace: chebi_ontology
def: "A drug used to treat trichomonas infections." []
subset: 3:STAR
synonym: "antitrichomonal agent" RELATED [chebi]
is_a: CHEBI:35820 ! antiprotozoal drug

[Term]
id: CHEBI:50694
name: minocycline
namespace: chebi_ontology
alt_id: CHEBI:44053
alt_id: CHEBI:6939
def: "A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5." []
subset: 3:STAR
synonym: "(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" EXACT [PDBeChem]
synonym: "(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" RELATED [pdb-ccd]
synonym: "7-Dimethylamino-6-demethyl-6-deoxytetracycline" RELATED [chemidplus]
synonym: "Minocycline" RELATED [kegg.compound]
synonym: "minomycin" RELATED [chebi]
is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone
is_a: CHEBI:26895 ! tetracyclines
is_a: CHEBI:48132 ! tetracenomycin
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018034 CHEBI:71337 ! minocycline(1-)
relationship: RO:0018036 CHEBI:77906 ! minocycline zwitterion

[Term]
id: CHEBI:50695
name: monobactam
namespace: chebi_ontology
def: "Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotic. It lacks the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized." []
subset: 3:STAR
synonym: "monobactams" RELATED [chebi]
is_a: CHEBI:27933 ! beta-lactam antibiotic

[Term]
id: CHEBI:50696
name: EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.4.1.* (hexosyltransferase) inhibitor that interferes with the action of peptidoglycan glycosyltransferase (EC 2.4.1.129)." []
subset: 3:STAR
synonym: "[poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitor" RELATED [chebi]
synonym: "[poly-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase inhibitors" RELATED [chebi]
synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitor" RELATED [chebi]
synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.129 inhibitor" RELATED [chebi]
synonym: "EC 2.4.1.129 inhibitors" RELATED [chebi]
synonym: "PBP3 inhibitor" RELATED [chebi]
synonym: "penicillin binding protein 1B inhibitor" RELATED [chebi]
synonym: "penicillin binding protein 1B inhibitors" RELATED [chebi]
synonym: "penicillin binding protein 3 inhibitor" RELATED [chebi]
synonym: "penicillin binding protein 3 inhibitors" RELATED [chebi]
synonym: "peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitor" RELATED [chebi]
synonym: "peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitors" RELATED [chebi]
synonym: "peptidoglycan glycosyltransferase inhibitor" RELATED [chebi]
synonym: "peptidoglycan glycosyltransferase inhibitors" RELATED [chebi]
synonym: "peptidoglycan transglycosylase inhibitor" RELATED [chebi]
synonym: "peptidoglycan transglycosylase inhibitors" RELATED [chebi]
synonym: "PG-II inhibitor" RELATED [chebi]
synonym: "PG-II inhibitors" RELATED [chebi]
synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitor" RELATED [chebi]
synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor

[Term]
id: CHEBI:50699
name: oligosaccharide
namespace: chebi_ontology
alt_id: CHEBI:25679
alt_id: CHEBI:35319
alt_id: CHEBI:7758
def: "A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues." []
subset: 3:STAR
synonym: "O-glycosylglycoside" RELATED [chebi]
synonym: "O-glycosylglycosides" RELATED [chebi]
synonym: "oligosacarido" RELATED [chebi]
synonym: "oligosacaridos" RELATED [iupac]
synonym: "Oligosaccharide" RELATED [kegg.compound]
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:167559 ! glycan

[Term]
id: CHEBI:50733
name: nutraceutical
namespace: chebi_ontology
def: "A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance." []
subset: 3:STAR
synonym: "Dietary Supplement" RELATED [chebi]
synonym: "Food Supplementation" RELATED [chebi]
synonym: "Nutritional supplement" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:50750
name: EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
namespace: chebi_ontology
alt_id: CHEBI:132229
alt_id: CHEBI:50234
def: "A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." []
subset: 3:STAR
synonym: "DNA gyrase inhibitor" RELATED [chebi]
synonym: "DNA gyrase inhibitors" RELATED [chebi]
synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitor" RELATED [chebi]
synonym: "DNA topoisomerase (ATP-hydrolysing) (EC 5.99.1.3) inhibitors" RELATED [chebi]
synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitor" RELATED [chebi]
synonym: "DNA topoisomerase (ATP-hydrolysing) inhibitors" RELATED [chebi]
synonym: "DNA topoisomerase II inhibitor" RELATED [chebi]
synonym: "DNA topoisomerase II inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor" RELATED [chebi]
synonym: "EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.3 inhibitor" RELATED [chebi]
synonym: "EC 5.99.1.3 inhibitors" RELATED [chebi]
synonym: "inhibitor of type II topoisomerase" RELATED [chebi]
synonym: "inhibitors of type II topoisomerase" RELATED [chebi]
synonym: "topoisomerase II inhibitor" RELATED [chebi]
synonym: "topoisomerase II inhibitors" RELATED [chebi]
synonym: "topoisomerase-II inhibitor" RELATED [chebi]
synonym: "topoisomerase-II inhibitors" RELATED [chebi]
synonym: "type II DNA topoisomerase inhibitor" RELATED [chebi]
synonym: "type II DNA topoisomerase inhibitors" RELATED [chebi]
is_a: CHEBI:70727 ! topoisomerase inhibitor

[Term]
id: CHEBI:50845
name: doxycycline
namespace: chebi_ontology
alt_id: CHEBI:42135
alt_id: CHEBI:4713
def: "Tetracycline in which the 5β-hydrogen is replaced by a hydroxy group, while the 6α-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis." []
subset: 3:STAR
synonym: "(4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" EXACT [PDBeChem]
synonym: "(4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE" RELATED [pdb-ccd]
synonym: "5-hydroxy-alpha-6-deoxytetracycline" RELATED [chemidplus]
synonym: "6alpha-deoxy-5-oxytetracycline" RELATED [chemidplus]
synonym: "Doxycyclin" RELATED [chebi]
synonym: "Doxycycline" RELATED [kegg.compound]
synonym: "doxycycline (anhydrous)" RELATED [chemidplus]
is_a: CHEBI:26895 ! tetracyclines
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:38068 ! has role antimalarial
relationship: RO:0000087 CHEBI:50846 ! has role immunomodulator
relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent

[Term]
id: CHEBI:50846
name: immunomodulator
namespace: chebi_ontology
def: "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." []
subset: 3:STAR
synonym: "Biomodulator" RELATED [chebi]
synonym: "Immune factor" RELATED [chebi]
synonym: "Immunologic factor" RELATED [chebi]
synonym: "Immunological factor" RELATED [chebi]
synonym: "immunomodulators" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:50847
name: immunological adjuvant
namespace: chebi_ontology
def: "A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity." []
subset: 3:STAR
synonym: "Immunoactivator" RELATED [chebi]
synonym: "Immunoadjuvant" RELATED [chebi]
synonym: "Immunologic adjuvant" RELATED [chebi]
synonym: "Immunopotentiator" RELATED [chebi]
synonym: "Immunostimulant" RELATED [chebi]
is_a: CHEBI:50846 ! immunomodulator
is_a: CHEBI:60809 ! adjuvant

[Term]
id: CHEBI:50860
name: organic molecular entity
namespace: chebi_ontology
alt_id: CHEBI:25700
alt_id: CHEBI:33244
def: "Any molecular entity that contains carbon." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic compounds" RELATED [ChEBI]
synonym: "organic compounds" RELATED [chebi]
synonym: "organic entity" RELATED [chebi]
synonym: "organic entity" RELATED [ChEBI]
synonym: "organic molecular entities" RELATED [ChEBI]
synonym: "organic molecular entities" RELATED [chebi]
is_a: CHEBI:33582 ! carbon group molecular entity
relationship: BFO:0000051 CHEBI:27594 ! has part carbon atom

[Term]
id: CHEBI:50893
name: azaarene
namespace: chebi_ontology
subset: 3:STAR
synonym: "azaarenes" RELATED [chebi]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:50902
name: genotoxin
namespace: chebi_ontology
def: "A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells." []
subset: 3:STAR
synonym: "genotoxic agent" RELATED [chebi]
synonym: "genotoxic agents" RELATED [chebi]
synonym: "genotoxins" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50903
name: carcinogenic agent
namespace: chebi_ontology
def: "A role played by a chemical compound which is known to  induce a process of carcinogenesis  by corrupting  normal cellular pathways, leading to the acquistion of tumoral capabilities." []
subset: 3:STAR
synonym: "agente carcinogeno" RELATED [chebi]
synonym: "cancerigene" RELATED [chebi]
synonym: "cancerogene" RELATED [chebi]
synonym: "carcinogen" RELATED [chebi]
synonym: "carcinogene" RELATED [chebi]
synonym: "carcinogenic agents" RELATED [chebi]
synonym: "carcinogeno" RELATED [chebi]
synonym: "carcinogens" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50904
name: allergen
namespace: chebi_ontology
def: "A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy." []
subset: 3:STAR
synonym: "alergeno" RELATED [chebi]
synonym: "allergene" RELATED [chebi]
synonym: "allergenic agent" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50906
name: role
namespace: chebi_ontology
def: "A role is particular behaviour which a material entity may exhibit." []
subset: 3:STAR
subset: 3_STAR

[Term]
id: CHEBI:50908
name: hepatotoxic agent
namespace: chebi_ontology
def: "A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals." []
subset: 3:STAR
synonym: "agente hepatotoxico" RELATED [chebi]
synonym: "hepatotoxic agents" RELATED [chebi]
synonym: "hepatotoxicant" RELATED [chebi]
synonym: "hepatotoxicants" RELATED [chebi]
synonym: "hepatotoxin" RELATED [chebi]
synonym: "hepatotoxins" RELATED [chebi]
synonym: "hepatoxic agent" RELATED [chebi]
synonym: "hepatoxicant" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50909
name: nephrotoxic agent
namespace: chebi_ontology
def: "A role played by any chemical compound (natural or synthetic) exhibiting itself through the ability to induce damage to the kidneys." []
subset: 3:STAR
synonym: "agente nefrotoxico" RELATED [chebi]
synonym: "nephrotoxic agents" RELATED [chebi]
synonym: "nephrotoxicant" RELATED [chebi]
is_a: CHEBI:52209 ! aetiopathogenetic role

[Term]
id: CHEBI:50910
name: neurotoxin
namespace: chebi_ontology
alt_id: CHEBI:50911
def: "A poison that interferes with the functions of the nervous system." []
subset: 3:STAR
subset: 3_STAR
synonym: "agente neurotoxico" RELATED [chebi]
synonym: "agente neurotoxico" RELATED [ChEBI]
synonym: "nerve poison" RELATED [ChEBI]
synonym: "nerve poison" RELATED [chebi]
synonym: "nerve poisons" RELATED [ChEBI]
synonym: "nerve poisons" RELATED [chebi]
synonym: "neurotoxic agent" RELATED [ChEBI]
synonym: "neurotoxic agent" RELATED [chebi]
synonym: "neurotoxic agents" RELATED [chebi]
synonym: "neurotoxic agents" RELATED [ChEBI]
synonym: "neurotoxicant" RELATED [chebi]
synonym: "neurotoxicant" RELATED [ChEBI]
synonym: "neurotoxins" RELATED [chebi]
synonym: "neurotoxins" RELATED [ChEBI]
xref: Wikipedia:Neurotoxin
is_a: CHEBI:52209 ! aetiopathogenetic role
is_a: CHEBI:64909 ! poison

[Term]
id: CHEBI:50994
name: primary amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." []
subset: 3:STAR
synonym: "primary amino compounds" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound
relationship: RO:0018033 CHEBI:65296 ! primary ammonium ion

[Term]
id: CHEBI:50995
name: secondary amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups." []
subset: 3:STAR
synonym: "secondary amino compounds" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:50996
name: tertiary amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups." []
subset: 3:STAR
synonym: "tertiary amino compounds" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound
relationship: RO:0018033 CHEBI:137982 ! tertiary ammonium ion

[Term]
id: CHEBI:5100
name: flucytosine
namespace: chebi_ontology
def: "An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections." []
subset: 3:STAR
synonym: "5-FC" RELATED [kegg.drug]
synonym: "5-Fluorocystosine" RELATED [chemidplus]
synonym: "5-Fluorocytosine" RELATED [chemidplus]
synonym: "Ancobon (TN)" RELATED [kegg.drug]
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:38337 ! pyrimidone
is_a: CHEBI:38338 ! aminopyrimidine
is_a: CHEBI:60783 ! nucleoside analogue
is_a: CHEBI:87205 ! pyrimidine antifungal drug
relationship: RO:0000087 CHEBI:50266 ! has role prodrug
relationship: RO:0018038 CHEBI:16040 ! cytosine

[Term]
id: CHEBI:51026
name: macrocycle
namespace: chebi_ontology
def: "A cyclic compound containing nine or more atoms as part of the cyclic system." []
subset: 3:STAR
synonym: "macrocycles" RELATED [chebi]
synonym: "Makrocyclen" RELATED [chebi]
synonym: "makrocyclische Verbindungen" RELATED [chebi]
synonym: "Makrozyklen" RELATED [chebi]
synonym: "makrozyklische Verbindungen" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:51061
name: hormone receptor modulator
namespace: chebi_ontology
def: "A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." []
subset: 3:STAR
synonym: "hormone receptor modulators" RELATED [chebi]
is_a: CHEBI:90710 ! receptor modulator

[Term]
id: CHEBI:51086
name: chemical role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof within a chemical context." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:51121
name: fluorescent dye
namespace: chebi_ontology
subset: 3:STAR
synonym: "fluorescent dyes" RELATED [chebi]
is_a: CHEBI:37958 ! dye

[Term]
id: CHEBI:51143
name: nitrogen molecular entity
namespace: chebi_ontology
alt_id: CHEBI:25556
alt_id: CHEBI:7594
subset: 3:STAR
subset: 3_STAR
synonym: "nitrogen compounds" RELATED [ChEBI]
synonym: "nitrogen compounds" RELATED [chebi]
synonym: "nitrogen molecular entities" RELATED [ChEBI]
synonym: "nitrogen molecular entities" RELATED [chebi]
synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND]
synonym: "Nitrogenous compounds" RELATED [kegg.compound]
xref: KEGG:C06061
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: BFO:0000051 CHEBI:25555 ! has part nitrogen atom

[Term]
id: CHEBI:51144
name: nitrogen group
namespace: chebi_ontology
subset: 3:STAR
synonym: "nitrogen group" RELATED [chebi]
synonym: "nitrogen groups" RELATED [chebi]
synonym: "nitrogen-containing group" RELATED [chebi]
synonym: "nitrogenous group" RELATED [chebi]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:51151
name: dipolar compound
namespace: chebi_ontology
def: "An  organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." []
subset: 3:STAR
subset: 3_STAR
synonym: "dipolar compounds" RELATED [chebi]
synonym: "dipolar compounds" RELATED [ChEBI]
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:51208
name: mecillinam
namespace: chebi_ontology
def: "A penicillin in which the 6β substituent is [(azepan-1-yl)methylidene]amino; an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "amdinocillin" RELATED [chemidplus]
synonym: "penicillin HX" RELATED [chemidplus]
is_a: CHEBI:17334 ! penicillin
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CHEBI:51217
name: fluorochrome
namespace: chebi_ontology
def: "A fluorescent dye used to stain biological specimens." []
subset: 3:STAR
synonym: "fluorochromes" RELATED [chebi]
is_a: CHEBI:51121 ! fluorescent dye

[Term]
id: CHEBI:51256
name: amoxicillin(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:2676 ! amoxicillin

[Term]
id: CHEBI:51269
name: acenes
namespace: chebi_ontology
def: "Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives." []
subset: 3:STAR
is_a: CHEBI:33836 ! benzenoid aromatic compound

[Term]
id: CHEBI:51270
name: tetracenes
namespace: chebi_ontology
def: "Compounds containing a tetracene skeleton." []
subset: 3:STAR
synonym: "naphthacenes" RELATED [chebi]
is_a: CHEBI:51269 ! acenes

[Term]
id: CHEBI:51276
name: thioureas
namespace: chebi_ontology
def: "Compounds of general formula RR'NC(=S)NR''R'''." []
subset: 3:STAR
is_a: CHEBI:50492 ! thiocarbonyl compound

[Term]
id: CHEBI:51308
name: dinitrile
namespace: chebi_ontology
def: "A dinitrile is a compound containing two nitrile groups." []
subset: 3:STAR
synonym: "dinitrile" RELATED [chebi]
synonym: "dinitriles" RELATED [chebi]
is_a: CHEBI:18379 ! nitrile

[Term]
id: CHEBI:51336
name: metal sulfate
namespace: chebi_ontology
def: "Sulfate salts where the cation is a metal ion." []
subset: 3:STAR
synonym: "metal sulfates" RELATED [chebi]
is_a: CHEBI:24840 ! inorganic sulfate salt

[Term]
id: CHEBI:51337
name: organic sulfate salt
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic sulfate salts" RELATED [chebi]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:35175 ! sulfate salt

[Term]
id: CHEBI:51354
name: benzylpenicillin(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
synonym: "penicillin G" RELATED [uniprot_ft]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:18208 ! benzylpenicillin

[Term]
id: CHEBI:51356
name: penicillinate anion
namespace: chebi_ontology
alt_id: CHEBI:58108
def: "Any anion formed by loss of a proton from the carboxy group of a penicillin." []
subset: 3:STAR
synonym: "a penicillin" RELATED [uniprot_ft]
synonym: "penicillin anion" RELATED [chebi]
synonym: "penicillin anions" RELATED [chebi]
is_a: CHEBI:47811 ! penamcarboxylate
relationship: RO:0018033 CHEBI:17334 ! penicillin

[Term]
id: CHEBI:51373
name: GABA agonist
namespace: chebi_ontology
def: "A drug that binds to and activates γ-aminobutyric acid receptors." []
subset: 3:STAR
synonym: "GABA agonists" RELATED [chebi]
synonym: "GABA receptor agonist" RELATED [chebi]
synonym: "GABA receptor agonists" RELATED [chebi]
synonym: "gamma-aminobutyric acid receptor agonist" RELATED [chebi]
synonym: "gamma-aminobutyric acid receptor agonists" RELATED [chebi]
is_a: CHEBI:51374 ! GABA agent

[Term]
id: CHEBI:51374
name: GABA agent
namespace: chebi_ontology
def: "A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems." []
subset: 3:STAR
is_a: CHEBI:35942 ! neurotransmitter agent

[Term]
id: CHEBI:51402
name: phenylenediamine
namespace: chebi_ontology
def: "A benzene substituted with two amino groups." []
subset: 3:STAR
synonym: "diaminobenzene" RELATED [chebi]
is_a: CHEBI:33860 ! aromatic amine
is_a: CHEBI:35410 ! primary diamine

[Term]
id: CHEBI:51422
name: organodiyl group
namespace: chebi_ontology
def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." []
subset: 3:STAR
subset: 3_STAR
synonym: "organodiyl groups" RELATED [ChEBI]
synonym: "organodiyl groups" RELATED [chebi]
is_a: CHEBI:51446 ! organic divalent group

[Term]
id: CHEBI:51446
name: organic divalent group
namespace: chebi_ontology
subset: 1:STAR
subset: 1_STAR
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51447
name: organic univalent group
namespace: chebi_ontology
subset: 1:STAR
subset: 1_STAR
synonym: "organic monovalent group" RELATED [chebi]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51454
name: cyclopropanes
namespace: chebi_ontology
def: "Cyclopropane and its derivatives formed by substitution." []
subset: 3:STAR
is_a: CHEBI:33598 ! carbocyclic compound

[Term]
id: CHEBI:51683
name: methoxybenzenes
namespace: chebi_ontology
def: "Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups." []
subset: 3:STAR
synonym: "methoxybenzene" RELATED [chebi]
is_a: CHEBI:22712 ! benzenes
is_a: CHEBI:35618 ! aromatic ether

[Term]
id: CHEBI:51689
name: enone
namespace: chebi_ontology
def: "An α,β-unsaturated ketone of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)R<small><sup>4</small></sup> (R<small><sup>4</small></sup> ≠ H) in which the C=O function is conjugated to a C=C double bond at the α,β position." []
subset: 3:STAR
synonym: "enones" RELATED [chebi]
is_a: CHEBI:51721 ! alpha,beta-unsaturated ketone
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:51702
name: enoate ester
namespace: chebi_ontology
def: "An α,β-unsaturated carboxylic ester of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)OR<small><sup>4</small></sup> (R<small><sup>4</small></sup> ≠ H) in which the ester C=O function is conjugated to a C=C double bond at the α,β position." []
subset: 3:STAR
synonym: "enoate" RELATED [chebi]
synonym: "enoate esters" RELATED [chebi]
synonym: "enoates" RELATED [chebi]
is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:51721
name: alpha,beta-unsaturated ketone
namespace: chebi_ontology
def: "A ketone of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)R<small><sup>4</small></sup> (R<small><sup>4</small></sup> ≠ H) or R<small><sup>1</small></sup>C≡C‒C(=O)R<small><sup>2</small></sup> (R<small><sup>2</small></sup> ≠ H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the α,β position." []
subset: 3:STAR
synonym: "alpha,beta-unsaturated ketones" RELATED [chebi]
is_a: CHEBI:17087 ! ketone

[Term]
id: CHEBI:51737
name: alpha,beta-unsaturated carboxylic ester
namespace: chebi_ontology
def: "A carboxylic ester of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)OR<small><sup>4</small></sup> (R<small><sup>4</small></sup> ≠ H) or R<small><sup>1</small></sup>C≡C‒C(=O)OR<small><sup>2</small></sup> (R<small><sup>2</small></sup> ≠ H) in which the ester C=O function is conjugated to an unsaturated C-C bond at the α,β position." []
subset: 3:STAR
synonym: "alpha,beta-unsaturated carboxylic esters" RELATED [chebi]
is_a: CHEBI:33308 ! carboxylic ester

[Term]
id: CHEBI:51750
name: alpha,beta-unsaturated carboxylic acid amide
namespace: chebi_ontology
def: "A monocarboxylic amide of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)NR<small><sup>4</small></sup>R<small><sup>5</small></sup>  or R<small><sup>1</small></sup>C≡C‒C(=O)NR<small><sup>2</small></sup>R<small><sup>3</small></sup> in which the amide C=O function is conjugated to an unsaturated C-C bond at the α,β position." []
subset: 3:STAR
synonym: "alpha,beta-unsaturated amide" RELATED [chebi]
synonym: "alpha,beta-unsaturated carboxamide" RELATED [chebi]
synonym: "alpha,beta-unsaturated monocarboxylic acid amide" RELATED [chebi]
synonym: "alpha,beta-unsaturated monocarboxylic acid amides" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:51751
name: enamide
namespace: chebi_ontology
def: "An α,β-unsaturated carboxylic acid amide of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)NR<small><sup>4</small></sup>R<small><sup>5</small></sup> in which the amide C=O function is conjugated to a C=C double bond at the α,β position." []
subset: 3:STAR
synonym: "enamides" RELATED [chebi]
is_a: CHEBI:51750 ! alpha,beta-unsaturated carboxylic acid amide
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:51811
name: ticarcillin(2-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:9587 ! ticarcillin

[Term]
id: CHEBI:51867
name: methyl ketone
namespace: chebi_ontology
def: "A ketone of formula RC(=O)CH<small><sub>3</sub></small> (R ≠ H)." []
subset: 3:STAR
synonym: "methyl ketones" RELATED [chebi]
is_a: CHEBI:17087 ! ketone

[Term]
id: CHEBI:51897
name: carbenicillin(2-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[carboxylato(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:3393 ! carbenicillin

[Term]
id: CHEBI:5195
name: furazolidone
namespace: chebi_ontology
def: "A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an <em>N</em>-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera." []
subset: 3:STAR
synonym: "3-(5'-Nitrofurfuralamino)-2-oxazolidone" RELATED [chemidplus]
synonym: "3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone" RELATED [chemidplus]
synonym: "3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone" RELATED [chemidplus]
synonym: "3-[(5-Nitrofurylidene)amino]-2-oxazolidone" RELATED [chemidplus]
synonym: "3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone" RELATED [chemidplus]
synonym: "5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine" RELATED [nist]
synonym: "Furazolidone" RELATED [kegg.compound]
synonym: "Furoxone" RELATED [kegg.drug]
synonym: "FZL" RELATED [chebi]
synonym: "N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone" RELATED [chemidplus]
synonym: "N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one" RELATED [chemidplus, nist]
synonym: "Nitrofurazolidone" RELATED [drugbank]
synonym: "Nitrofurazolidonum" RELATED [drugbank]
is_a: CHEBI:38329 ! oxazolidines
is_a: CHEBI:87230 ! nitrofuran antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:38623 ! has role EC 1.4.3.4 (monoamine oxidase) inhibitor
relationship: RO:0000087 CHEBI:50685 ! has role antitrichomonal drug

[Term]
id: CHEBI:51958
name: organic polycyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic polycyclic compounds" RELATED [chebi]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:51959
name: organic tricyclic compound
namespace: chebi_ontology
subset: 3:STAR
synonym: "organic tricyclic compounds" RELATED [chebi]
is_a: CHEBI:51958 ! organic polycyclic compound

[Term]
id: CHEBI:52017
name: dicloxacillin(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:4511 ! dicloxacillin

[Term]
id: CHEBI:52064
name: methicillin(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [iupac]
synonym: "6beta-(2,6-dimethoxybenzamido)penicillanate" RELATED [chebi]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:6827 ! methicillin

[Term]
id: CHEBI:52090
name: methoxide
namespace: chebi_ontology
def: "An organic anion that is the conjugate base of methanol." []
subset: 3:STAR
synonym: "methoxide ion" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:17790 ! methanol

[Term]
id: CHEBI:52132
name: oxacillin(1-)
namespace: chebi_ontology
subset: 3:STAR
synonym: "6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanate" RELATED [chebi]
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:7809 ! oxacillin

[Term]
id: CHEBI:52206
name: biochemical role
namespace: chebi_ontology
def: "A biological role played by the molecular entity or part thereof within a biochemical context." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52208
name: biophysical role
namespace: chebi_ontology
subset: 1:STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52209
name: aetiopathogenetic role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." []
subset: 3:STAR
subset: 3_STAR
synonym: "etiopathogenetic agent" RELATED [ChEBI]
synonym: "etiopathogenetic agent" RELATED [chebi]
synonym: "etiopathogenetic role" RELATED [ChEBI]
synonym: "etiopathogenetic role" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52210
name: pharmacological role
namespace: chebi_ontology
def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." []
subset: 3:STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52211
name: physiological role
namespace: chebi_ontology
def: "A biological role relating to the normal mechanisms and their interactions within a living system." []
subset: 1:STAR
subset: 1_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52214
name: ligand
namespace: chebi_ontology
def: "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." []
subset: 3:STAR
synonym: "ligands" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:52217
name: pharmaceutical
namespace: chebi_ontology
alt_id: CHEBI:33293
alt_id: CHEBI:33294
def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." []
subset: 3:STAR
synonym: "farmaco" RELATED [chebi]
synonym: "medicament" RELATED [chebi]
synonym: "pharmaceuticals" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:52362
name: ortho-fused heteroarene
namespace: chebi_ontology
def: "An <em>ortho</em>-fused compound in which at least one of the rings contains at least one heteroatom." []
subset: 3:STAR
synonym: "ortho-fused heteroarenes" RELATED [chebi]
is_a: CHEBI:33637 ! ortho-fused compound
is_a: CHEBI:38180 ! polycyclic heteroarene

[Term]
id: CHEBI:52433
name: piperacillin(1-)
namespace: chebi_ontology
subset: 3:STAR
is_a: CHEBI:51356 ! penicillinate anion
relationship: RO:0018033 CHEBI:8232 ! piperacillin

[Term]
id: CHEBI:52440
name: cephalosporin carboxylic acid anion
namespace: chebi_ontology
subset: 3:STAR
synonym: "cephalosporin carboxylate" RELATED [chebi]
synonym: "cephalosporin carboxylates" RELATED [chebi]
synonym: "cephalosporin carboxylic acid anions" RELATED [chebi]
synonym: "cephalosporincarboxylate" RELATED [chebi]
is_a: CHEBI:29067 ! carboxylic acid anion

[Term]
id: CHEBI:52492
name: mancozeb
namespace: chebi_ontology
def: "A mixture composed from maneb and zineb, which is used as a broad-spectrum contact fungicide." []
subset: 3:STAR
synonym: "ethylenebis(dithiocarbamic acid) manganese zinc complex" RELATED [chemidplus]
synonym: "Mancozeb" RELATED [kegg.compound]
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:52497 ! has part maneb
relationship: BFO:0000051 CHEBI:52498 ! has part zineb
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:52497
name: maneb
namespace: chebi_ontology
def: "A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab." []
subset: 3:STAR
synonym: "manganese ethane-1,2-diyldicarbamodithioate" RELATED [iupac]
is_a: CHEBI:60027 ! polymer
relationship: BFO:0000051 CHEBI:35117 ! has part manganese coordination entity
relationship: BFO:0000051 CHEBI:83060 ! has part dithiocarbamate salt
relationship: RO:0000087 CHEBI:50910 ! has role neurotoxin
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:52498
name: zineb
namespace: chebi_ontology
def: "A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU." []
subset: 3:STAR
synonym: "zinc ethane-1,2-diyldicarbamodithioate" RELATED [iupac]
is_a: CHEBI:33839 ! macromolecule
is_a: CHEBI:36566 ! zinc coordination entity
is_a: CHEBI:83060 ! dithiocarbamate salt
relationship: BFO:0000051 CHEBI:77308 ! has part ethylenebis(dithiocarbamate)
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:52549
name: sordarin
namespace: chebi_ontology
def: "An antifungal metabolite of <em>Sordaria araneosa</em> that inhibits protein synthesis. It has a tetracyclic diterpene glycoside structure." []
subset: 3:STAR
synonym: "Antibiotic SL-2266" RELATED [chemidplus]
synonym: "sordarin B" RELATED [submitter]
is_a: CHEBI:24400 ! glycoside
is_a: CHEBI:52557 ! tetracyclic diterpenoid
is_a: CHEBI:63367 ! monosaccharide derivative
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor

[Term]
id: CHEBI:52557
name: tetracyclic diterpenoid
namespace: chebi_ontology
def: "A diterpenoid with a tetracyclic skeleton." []
subset: 3:STAR
synonym: "tetracyclic diterpenoids" RELATED [chebi]
is_a: CHEBI:23849 ! diterpenoid

[Term]
id: CHEBI:52646
name: leptomycin B
namespace: chebi_ontology
def: "A leptomycin having a (2<i>E</i>,10<i>E</i>,12<i>E</i>,16<i>Z</i>,18<i>E</i>)-double bond configuration as well as an ethyl substituent at position 17." []
subset: 3:STAR
synonym: "antibiotic ATS 1287B" RELATED [chebi]
synonym: "Antibiotic CI 940" RELATED [chemidplus]
synonym: "Antibiotic CL 1957A" RELATED [chemidplus]
synonym: "Antibiotic PD 114720" RELATED [chebi]
synonym: "ATS 1287B" RELATED [chebi]
synonym: "LMB" RELATED [chebi]
is_a: CHEBI:140345 ! hydroxy polyunsaturated fatty acid
is_a: CHEBI:52651 ! leptomycin
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:52651
name: leptomycin
namespace: chebi_ontology
def: "A complex, very long chain, polyunsaturated fatty acid whose core structure comprises 8-oxononadeca-2,10,12,16,18-pentaenoic acid having methyl substituents at positions 3, 5, 7, 9, 11 and 15 and a 3,6-dihydropyran-6-one-2-yl group at position 19." []
subset: 3:STAR
synonym: "leptomycins" RELATED [chebi]
is_a: CHEBI:24654 ! hydroxy fatty acid
is_a: CHEBI:25000 ! lactone
is_a: CHEBI:26208 ! polyunsaturated fatty acid
is_a: CHEBI:27283 ! very long-chain fatty acid
is_a: CHEBI:35819 ! branched-chain fatty acid
is_a: CHEBI:59644 ! oxo fatty acid
is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid
relationship: RO:0018038 CHEBI:28866 ! tetracosanoic acid

[Term]
id: CHEBI:52726
name: proteasome inhibitor
namespace: chebi_ontology
def: "A drug that blocks the action of proteasomes, cellular complexes that break down proteins." []
subset: 3:STAR
synonym: "proteasome inhibitors" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:5280
name: gatifloxacin
namespace: chebi_ontology
alt_id: CHEBI:101712
def: "A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes." []
subset: 3:STAR
synonym: "1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid" RELATED [chemidplus]
synonym: "1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid" RELATED [chembl]
synonym: "AM 1155" RELATED [kegg.compound]
is_a: CHEBI:23765 ! quinolone
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:86324 ! quinolone antibiotic
relationship: RO:0000087 CHEBI:35441 ! has role antiinfective agent
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor

[Term]
id: CHEBI:52898
name: azamacrocycle
namespace: chebi_ontology
def: "A cyclic macromolecule containing one or more nitrogen atoms in place of carbon either as the divalent group NH for the group CH2 or a single trivalent nitrogen atom for the group CH." []
subset: 3:STAR
synonym: "aza macrocycle" RELATED [submitter]
synonym: "aza macrocyclic compound" RELATED [submitter]
synonym: "aza-macrocycle" RELATED [submitter]
synonym: "azamacrocycles" RELATED [chebi]
is_a: CHEBI:51026 ! macrocycle

[Term]
id: CHEBI:53000
name: epitope
namespace: chebi_ontology
def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." []
subset: 3:STAR
synonym: "antigenic determinant" RELATED [chebi]
synonym: "epitope function" RELATED [chebi]
synonym: "epitope role" RELATED [chebi]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:53559
name: topoisomerase IV inhibitor
namespace: chebi_ontology
def: "A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands." []
subset: 3:STAR
synonym: "topoisomerase IV inhibitors" RELATED [chebi]
is_a: CHEBI:70727 ! topoisomerase inhibitor

[Term]
id: CHEBI:53628
name: 2,6-dideoxy-alpha-D-glucoside
namespace: chebi_ontology
def: "An α-<small>D</small>-glucoside deoxygenated at C-2 and C-6." []
subset: 3:STAR
is_a: CHEBI:22390 ! alpha-D-glucoside

[Term]
id: CHEBI:53634
name: neomycin C
namespace: chebi_ontology
def: "A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine C." []
subset: 3:STAR
is_a: CHEBI:47779 ! aminoglycoside
relationship: RO:0018033 CHEBI:65077 ! neomycin C(6+)

[Term]
id: CHEBI:53655
name: cefoxitin(1-)
namespace: chebi_ontology
def: "A cephalosporin carboxylic acid anion having methoxy, 2-thienylacetamido and carbamoyloxymethyl side-groups, formed by proton loss from the carboxy group of the semisynthetic cephamycin antibiotic cefoxitin." []
subset: 3:STAR
synonym: "(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [iupac]
is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion
relationship: RO:0018033 CHEBI:209807 ! cefoxitin

[Term]
id: CHEBI:53657
name: cefazolin(1-)
namespace: chebi_ontology
def: "A cephalosporin carboxylic acid anion having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1<em>H</em>-tetrazol-1-ylacetyl)amino side-groups, formed by proton loss from the carboxy group of cefazolin." []
subset: 3:STAR
synonym: "(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [iupac]
is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion
relationship: RO:0018033 CHEBI:474053 ! cefazolin

[Term]
id: CHEBI:53658
name: ceftriaxone(1-)
namespace: chebi_ontology
def: "A cephalosporin carboxylis acid anion having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups, formed by proton loss from the carboxy group of ceftriaxone." []
subset: 3:STAR
is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion
relationship: RO:0018033 CHEBI:29007 ! ceftriaxone

[Term]
id: CHEBI:53661
name: alexidine
namespace: chebi_ontology
def: "An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge." []
subset: 3:STAR
synonym: "1,1'-Hexamethylenebis(5-(2-ethylhexyl)biguanide)" RELATED [chemidplus]
synonym: "bisguadine" RELATED [chebi]
synonym: "N,N'-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide" RELATED [chemidplus]
is_a: CHEBI:53662 ! biguanides
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent

[Term]
id: CHEBI:53662
name: biguanides
namespace: chebi_ontology
alt_id: CHEBI:35529
def: "A class of oral hypoglycemic drugs used for diabetes mellitus or prediabetes treatment. They have a structure based on the 2-carbamimidoylguanidine skeleton." []
subset: 3:STAR
is_a: CHEBI:24436 ! guanidines
relationship: RO:0000087 CHEBI:35526 ! has role hypoglycemic agent

[Term]
id: CHEBI:53665
name: oxazinoquinoline
namespace: chebi_ontology
def: "Any organic heterotricyclic compound based on a skeleton comprised of an oxazine ring fused onto a quinoline system." []
subset: 3:STAR
synonym: "oxazinoquinolines" RELATED [chebi]
is_a: CHEBI:26979 ! organic heterotricyclic compound

[Term]
id: CHEBI:53670
name: cefotaxime(1-)
namespace: chebi_ontology
def: "A cephalosporin carboxylic acid anion having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups, formed by proton loss from the carboxy group of the cephalosporin cefotaxime." []
subset: 3:STAR
synonym: "(6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [iupac]
is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion
relationship: RO:0018033 CHEBI:204928 ! cefotaxime

[Term]
id: CHEBI:53676
name: ceftazidime(1-)
namespace: chebi_ontology
def: "A cephalosporin carboxylic acid anion formed by proton loss from the carboxy group of ceftazidime, a cephalosporin having 7β-[(2<i>Z</i>)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino and 3-pyridinium-1-ylmethyl side-groups." []
subset: 3:STAR
synonym: "(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxylatopropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate" RELATED [iupac]
is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion
relationship: RO:0018033 CHEBI:3508 ! ceftazidime

[Term]
id: CHEBI:5385
name: gliotoxin
namespace: chebi_ontology
def: "A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi." []
subset: 3:STAR
synonym: "Aspergillin" RELATED [chemidplus]
is_a: CHEBI:35489 ! organic disulfide
is_a: CHEBI:38163 ! organic heterotetracyclic compound
is_a: CHEBI:46761 ! dipeptide
is_a: CHEBI:64130 ! pyrazinoindole
relationship: RO:0000087 CHEBI:25442 ! has role mycotoxin
relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:52726 ! has role proteasome inhibitor
relationship: RO:0000087 CHEBI:64133 ! has role EC 2.5.1.58 (protein farnesyltransferase) inhibitor

[Term]
id: CHEBI:5435
name: piperidine-2,6-dione
namespace: chebi_ontology
def: "A dicarboximide that is piperidine which is substituted by oxo groups at positions 2 and 6." []
subset: 3:STAR
synonym: "2,6-Diketopiperidine" RELATED [kegg.compound]
synonym: "2,6-piperidinedione" RELATED [chemidplus]
synonym: "Glutarimide" RELATED [kegg.compound]
synonym: "Piperidine-2,6-dione" RELATED [kegg.compound]
is_a: CHEBI:35356 ! dicarboximide
is_a: CHEBI:48589 ! piperidones

[Term]
id: CHEBI:5530
name: gramicidin S
namespace: chebi_ontology
subset: 3:STAR
synonym: "Cyclo(L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl)" RELATED [chemidplus]
synonym: "gramicidin" RELATED [chebi]
synonym: "Gramicidin C" RELATED [chemidplus]
synonym: "Gramicidin S" RELATED [kegg.compound]
synonym: "Gramicin S 1" RELATED [chemidplus]
synonym: "Gramicin S-A" RELATED [chebi]
is_a: CHEBI:24613 ! homodetic cyclic peptide

[Term]
id: CHEBI:55346
name: anidulafungin
namespace: chebi_ontology
def: "A semisynthetic echinocandin anti-fungal drug. It is active against <em>Aspergillus</em> and <em>Candida</em> species and is used for the treatment of invasive candidiasis." []
subset: 3:STAR
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:52898 ! azamacrocycle
is_a: CHEBI:57248 ! echinocandin
is_a: CHEBI:72588 ! semisynthetic derivative
is_a: CHEBI:87113 ! antibiotic antifungal drug

[Term]
id: CHEBI:55370
name: imidazolidinone
namespace: chebi_ontology
def: "An imidazolidine containing one or more oxo groups." []
subset: 3:STAR
synonym: "imidazolidinones" RELATED [chebi]
is_a: CHEBI:38261 ! imidazolidines

[Term]
id: CHEBI:55373
name: isoxazoles
namespace: chebi_ontology
alt_id: CHEBI:46813
def: "Oxazoles in which the N and O atoms are adjacent." []
subset: 3:STAR
synonym: "1,2-oxazoles" RELATED [chebi]
synonym: "isoxazoles" RELATED [chebi]
is_a: CHEBI:35790 ! oxazole

[Term]
id: CHEBI:55374
name: oxazolidinone
namespace: chebi_ontology
def: "An oxazolidine containing one or more oxo groups." []
subset: 3:STAR
synonym: "oxazolidinedione" RELATED [chebi]
synonym: "oxazolidinediones" RELATED [chebi]
synonym: "oxazolidinones" RELATED [chebi]
is_a: CHEBI:38329 ! oxazolidines

[Term]
id: CHEBI:55429
name: cephamycin
namespace: chebi_ontology
def: "Any member of the cephamycin sub-group of cephem antibiotics, differing from cephalosporins in possessing a methoxy group at the 7α-position of the cephem nucleus, and in being resistant to β-lactamase." []
subset: 3:STAR
synonym: "cephamycins" RELATED [chebi]
is_a: CHEBI:38311 ! cephem

[Term]
id: CHEBI:55517
name: trichothecene
namespace: chebi_ontology
def: "Any one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain." []
subset: 3:STAR
synonym: "trichothecenes" RELATED [chebi]
is_a: CHEBI:26658 ! sesquiterpenoid
is_a: CHEBI:32955 ! epoxide
is_a: CHEBI:38166 ! organic heteropolycyclic compound
relationship: RO:0000087 CHEBI:25442 ! has role mycotoxin

[Term]
id: CHEBI:5653
name: hemiacetal
namespace: chebi_ontology
def: "A compound having the general formula RR'C(OH)OR'' (R'' ≠ H)." []
subset: 3:STAR
synonym: "Hemiacetal" RELATED [kegg.compound]
synonym: "hemiacetals" RELATED [chebi]
is_a: CHEBI:30879 ! alcohol

[Term]
id: CHEBI:5686
name: heterocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of at least two different elements." []
subset: 3:STAR
subset: 3_STAR
synonym: "compuesto heterociclico" RELATED [IUPAC]
synonym: "compuesto heterociclico" RELATED [iupac]
synonym: "compuestos heterociclicos" RELATED [iupac]
synonym: "compuestos heterociclicos" RELATED [IUPAC]
synonym: "heterocycle" RELATED [chebi]
synonym: "heterocycle" RELATED [ChEBI]
synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND]
synonym: "Heterocyclic compound" RELATED [kegg.compound]
synonym: "heterocyclic compounds" RELATED [ChEBI]
synonym: "heterocyclic compounds" RELATED [chebi]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:57248
name: echinocandin
namespace: chebi_ontology
def: "Any one of a family of large lipopeptides that are inhibitors of the enzyme 1,3-β-glucan synthase, thus damaging fungal cell walls. Echinocandins are fungicidal against most <em>Candida</em> spp and fungistatic against <em>Aspergillus</em> spp." []
subset: 3:STAR
synonym: "echinocandins" RELATED [chebi]
is_a: CHEBI:46895 ! lipopeptide
is_a: CHEBI:86478 ! antibiotic antifungal agent
relationship: RO:0000087 CHEBI:230471 ! has role EC 2.4.1.34 (1,3-beta-glucan synthase) inhibitor

[Term]
id: CHEBI:57726
name: D-proline zwitterion
namespace: chebi_ontology
def: "A <small>D</small>-α-amino acid zwitterion that is <small>D</small>-proline in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." []
subset: 3:STAR
synonym: "D-proline" RELATED [uniprot_ft]
is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion
relationship: RO:0018036 CHEBI:16313 ! D-proline

[Term]
id: CHEBI:57869
name: 6-aminopenicillanic acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of 6-aminopenicillanic acid arising from migration of a proton from the carboxy group to the 6-amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-azaniumyl-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate" RELATED [chebi]
synonym: "6-aminopenicillanate" RELATED [uniprot_ft]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018034 CHEBI:30938 ! 6-aminopenicillanate
relationship: RO:0018036 CHEBI:16705 ! 6-aminopenicillanic acid

[Term]
id: CHEBI:57971
name: hygromycin B(3+)
namespace: chebi_ontology
def: "An ammonium ion that is the trication of hygromycin B arising from protonation of the three amino groups; major species at pH 7.3." []
subset: 3:STAR
synonym: "hygromycin B" RELATED [uniprot_ft]
synonym: "hygromycin B trication" RELATED [chebi]
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:16976 ! hygromycin B

[Term]
id: CHEBI:58007
name: streptomycin(3+)
namespace: chebi_ontology
def: "Trication of streptomycin arising from protonation of the guanidino and secondary amino groups." []
subset: 3:STAR
synonym: "streptomycin" RELATED [uniprot_ft]
synonym: "streptomycin trication" RELATED [chebi]
is_a: CHEBI:60251 ! guanidinium ion
relationship: RO:0018034 CHEBI:17076 ! streptomycin

[Term]
id: CHEBI:58165
name: 3',5'-cyclic AMP(1-)
namespace: chebi_ontology
def: "An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3." []
subset: 3:STAR
synonym: "3',5'-cyclic AMP" RELATED [uniprot_ft]
synonym: "3',5'-cyclic AMP anion" RELATED [chebi]
synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [chebi]
synonym: "adenosine 3',5'-cyclic monophosphate anion" RELATED [chebi]
synonym: "adenosine 3',5'-cyclic monophosphate(1-)" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0018033 CHEBI:17489 ! 3',5'-cyclic AMP

[Term]
id: CHEBI:582124
name: myriocin
namespace: chebi_ontology
def: "An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity." []
subset: 3:STAR
synonym: "(2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic acid" RELATED [chebi]
synonym: "(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid" RELATED [chebi]
synonym: "antibiotic ISP-1" RELATED [chebi]
synonym: "antibiotic ISP-I" RELATED [chebi]
synonym: "ISP-1" RELATED [kegg.compound]
synonym: "ISP-I" RELATED [chebi]
synonym: "thermozymocidin" RELATED [chemidplus]
is_a: CHEBI:35785 ! sphingoid
is_a: CHEBI:35868 ! hydroxy monocarboxylic acid
is_a: CHEBI:59755 ! alpha-amino fatty acid
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:59647 ! has role EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer
relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite

[Term]
id: CHEBI:58214
name: kanamycin A(4+)
namespace: chebi_ontology
def: "A quadruply-charged organic cation arising from protonation of the four amino groups of kanamycin A; major species at pH 7.3." []
subset: 3:STAR
synonym: "kanamycin A" RELATED [uniprot_ft]
synonym: "kanamycin A tetracation" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018034 CHEBI:17630 ! kanamycin A

[Term]
id: CHEBI:5827
name: hymexazol
namespace: chebi_ontology
def: "A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by <em>Fusarium</em>, <em>Aphanomyces</em>, <em>Pythium</em>, and <em>Corticium</em> spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals." []
subset: 3:STAR
synonym: "3-Hydroxy-5-methylisoxazole" RELATED [chemidplus]
synonym: "5-Methyl-3(2H)-isoxazolone" RELATED [chemidplus]
synonym: "5-Methyl-3-hydroxyisoxazole" RELATED [chemidplus]
synonym: "5-Methylisoxazol-3-ol" RELATED [chemidplus]
synonym: "F 319" RELATED [chemidplus]
synonym: "F-319" RELATED [chemidplus]
synonym: "Hydroxyisoxazole" RELATED [chemidplus]
synonym: "Hymexazole" RELATED [chemidplus]
synonym: "NSC 217971" RELATED [chemidplus]
synonym: "SF-6505" RELATED [chemidplus]
is_a: CHEBI:55373 ! isoxazoles
is_a: CHEBI:74818 ! heteroaryl hydroxy compound
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:58464
name: nucleoside 3',5'-cyclic phosphate anion
namespace: chebi_ontology
def: "The conjugate base of a nucleoside 3',5'-cyclic phosphate." []
subset: 3:STAR
synonym: "a nucleoside 3',5'-cyclic phosphate" RELATED [uniprot_ft]
synonym: "nucleoside 3',5'-cyclic phosphate anions" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate

[Term]
id: CHEBI:58549
name: kanamycin B(5+)
namespace: chebi_ontology
def: "An organic cation that is the pentacation of kanamycin B, obtained by protonation of the primary amino groups." []
subset: 3:STAR
synonym: "kanamycin B" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:28098 ! kanamycin B

[Term]
id: CHEBI:58942
name: cationic amino-acid residue
namespace: chebi_ontology
def: "An amino-acid residue protonated on nitrogen." []
subset: 3:STAR
subset: 3_STAR
synonym: "amino acid cation residue" RELATED [chebi]
synonym: "amino acid cation residue" RELATED [ChEBI]
synonym: "amino acid cation residues" RELATED [chebi]
synonym: "amino acid cation residues" RELATED [ChEBI]
synonym: "amino-acid cation residue" RELATED [chebi]
synonym: "amino-acid cation residue" RELATED [ChEBI]
synonym: "amino-acid cation residues" RELATED [chebi]
synonym: "amino-acid cation residues" RELATED [ChEBI]
synonym: "cationic amino acid residue" RELATED [ChEBI]
synonym: "cationic amino acid residue" RELATED [chebi]
synonym: "cationic amino acid residues" RELATED [ChEBI]
synonym: "cationic amino acid residues" RELATED [chebi]
synonym: "cationic amino-acid residues" RELATED [chebi]
synonym: "cationic amino-acid residues" RELATED [ChEBI]
is_a: CHEBI:64769 ! organic cationic group
relationship: is_conjugate_acid_of CHEBI:33708 ! amino-acid residue
relationship: RO:0018034 CHEBI:33708 ! amino-acid residue

[Term]
id: CHEBI:58945
name: organophosphate oxoanion
namespace: chebi_ontology
def: "An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated." []
subset: 3:STAR
synonym: "organophosphate oxoanions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:26079 ! phosphoric acid derivative

[Term]
id: CHEBI:58950
name: very long-chain fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion with a chain length greater than C<small><sub>22</sub></small>." []
subset: 3:STAR
synonym: "a very long-chain fatty acid" RELATED [uniprot_ft]
synonym: "very long-chain fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:27283 ! very long-chain fatty acid

[Term]
id: CHEBI:58951
name: short-chain fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>)." []
subset: 3:STAR
synonym: "a short-chain fatty acid" RELATED [uniprot_ft]
synonym: "short-chain fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:26666 ! short-chain fatty acid

[Term]
id: CHEBI:58953
name: saturated fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion in which there is no C‒C unsaturation." []
subset: 3:STAR
synonym: "saturated fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion

[Term]
id: CHEBI:58954
name: straight-chain saturated fatty acid anion
namespace: chebi_ontology
def: "Any saturated fatty acid anion lacking a carbon side-chain." []
subset: 3:STAR
synonym: "straight-chain saturated fatty acid anions" RELATED [chebi]
is_a: CHEBI:58953 ! saturated fatty acid anion
relationship: RO:0018033 CHEBI:39418 ! straight-chain saturated fatty acid

[Term]
id: CHEBI:58955
name: branched-chain fatty acid anion
namespace: chebi_ontology
def: "Any fatty acid anion with a carbon side-chain or isopropyl termination." []
subset: 3:STAR
synonym: "branched-chain fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:35819 ! branched-chain fatty acid

[Term]
id: CHEBI:58958
name: organosulfate oxoanion
namespace: chebi_ontology
def: "An organic anion of general formula RS(=O)2O(−) where R is an organyl group." []
subset: 3:STAR
synonym: "organosulfate oxoanions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: RO:0018033 CHEBI:25704 ! organic sulfate
relationship: RO:0018038 CHEBI:16189 ! sulfate

[Term]
id: CHEBI:59062
name: polymyxin
namespace: chebi_ontology
def: "Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium <em>Bacillus polymyxa</em> and are selectively toxic for Gram-negative bacteria." []
subset: 3:STAR
synonym: "polymixin" RELATED [chebi]
synonym: "polymycin" RELATED [chebi]
synonym: "polymyxins" RELATED [chebi]
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:46895 ! lipopeptide
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent

[Term]
id: CHEBI:59064
name: colistin A
namespace: chebi_ontology
subset: 3:STAR
synonym: "Colistin A" RELATED [chemidplus]
synonym: "Colistin IV" RELATED [chemidplus]
synonym: "Polymixin E1" RELATED [chemidplus]
synonym: "Polymyxin E1" RELATED [chemidplus]
is_a: CHEBI:25903 ! peptide antibiotic
is_a: CHEBI:59062 ! polymyxin

[Term]
id: CHEBI:59066
name: oxolinate
namespace: chebi_ontology
def: "Conjugate base of oxolinic acid." []
subset: 3:STAR
synonym: "5-ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylate" RELATED [iupac]
is_a: CHEBI:38773 ! quinolinemonocarboxylate
relationship: RO:0018033 CHEBI:138856 ! oxolinic acid

[Term]
id: CHEBI:59107
name: EC 3.4.24.* (metalloendopeptidase) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:76786
def: "Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*)." []
subset: 3:STAR
synonym: "EC 3.4.24.* (metalloendopeptidase) inhibitors" RELATED [chebi]
synonym: "EC 3.4.24.* inhibitor" RELATED [chebi]
synonym: "EC 3.4.24.* inhibitors" RELATED [chebi]
synonym: "inhibitor of metalloendopeptidases" RELATED [chebi]
synonym: "inhibitor of metalloendopeptidases (EC 3.4.24.*)" RELATED [chebi]
synonym: "inhibitors of metalloendopeptidases" RELATED [chebi]
synonym: "inhibitors of metalloendopeptidases (EC 3.4.24.*)" RELATED [chebi]
synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitor" RELATED [chebi]
synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitors" RELATED [chebi]
synonym: "metalloendopeptidase inhibitors" RELATED [chebi]
is_a: CHEBI:37670 ! protease inhibitor

[Term]
id: CHEBI:59163
name: biomarker
namespace: chebi_ontology
def: "A substance used as an indicator  of a biological state." []
subset: 3:STAR
synonym: "biological marker" RELATED [chebi]
is_a: CHEBI:47867 ! indicator

[Term]
id: CHEBI:59202
name: straight-chain fatty acid
namespace: chebi_ontology
def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." []
subset: 3:STAR
synonym: "straight-chain fatty acids" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:59203 ! straight-chain fatty acid anion

[Term]
id: CHEBI:59203
name: straight-chain fatty acid anion
namespace: chebi_ontology
def: "A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid." []
subset: 3:STAR
synonym: "straight-chain FA anion" RELATED [chebi]
synonym: "straight-chain FA anions" RELATED [chebi]
synonym: "straight-chain fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:59202 ! straight-chain fatty acid

[Term]
id: CHEBI:59285
name: EC 1.14.13.132 (squalene monooxygenase) inhibitor
namespace: chebi_ontology
def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132)." []
subset: 3:STAR
synonym: "EC 1.14.13.132 (squalene monooxygenase) inhibitors" RELATED [chebi]
synonym: "squalene 2,3-oxidocyclase inhibitor" RELATED [chebi]
synonym: "squalene 2,3-oxidocyclase inhibitors" RELATED [chebi]
synonym: "squalene epoxidase inhibitor" RELATED [chebi]
synonym: "squalene epoxidase inhibitors" RELATED [chebi]
synonym: "squalene hydroxylase inhibitor" RELATED [chebi]
synonym: "squalene hydroxylase inhibitors" RELATED [chebi]
synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitor" RELATED [chebi]
synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitors" RELATED [chebi]
synonym: "squalene monooxygenase inhibitor" RELATED [chebi]
synonym: "squalene monooxygenase inhibitors" RELATED [chebi]
synonym: "squalene oxydocyclase inhibitor" RELATED [chebi]
synonym: "squalene oxydocyclase inhibitors" RELATED [chebi]
synonym: "squalene-2,3-epoxidase inhibitor" RELATED [chebi]
synonym: "squalene-2,3-epoxidase inhibitors" RELATED [chebi]
synonym: "squalene-2,3-epoxide cyclase inhibitor" RELATED [chebi]
synonym: "squalene-2,3-epoxide cyclase inhibitors" RELATED [chebi]
is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor

[Term]
id: CHEBI:59349
name: cefepime(1+)
namespace: chebi_ontology
def: "The conjugate acid of cefepime." []
subset: 3:STAR
synonym: "cefepime conjugate acid" RELATED [chebi]
is_a: CHEBI:23066 ! cephalosporin
relationship: RO:0018034 CHEBI:478164 ! cefepime

[Term]
id: CHEBI:59358
name: cefotetan(2-)
namespace: chebi_ontology
def: "The dianion formed by removal of a proton from each of the carboxylic acid groups of cefotetan." []
subset: 3:STAR
synonym: "cefotetan dianion" RELATED [chebi]
is_a: CHEBI:28965 ! dicarboxylic acid dianion
relationship: RO:0018033 CHEBI:3499 ! cefotetan

[Term]
id: CHEBI:59392
name: cephalexin(1-)
namespace: chebi_ontology
def: "The anion resulting from the removal of a proton from the carboxylic acid group of cephalexin." []
subset: 3:STAR
synonym: "cefalexin anion" RELATED [chebi]
synonym: "cefalexin(1-)" RELATED [chebi]
synonym: "cephalexin anion" RELATED [chebi]
is_a: CHEBI:52440 ! cephalosporin carboxylic acid anion
relationship: RO:0018033 CHEBI:3534 ! cephalexin

[Term]
id: CHEBI:59517
name: DNA synthesis inhibitor
namespace: chebi_ontology
def: "Any substance that inhibits the synthesis of DNA." []
subset: 3:STAR
synonym: "DNA synthesis inhibitors" RELATED [chebi]
is_a: CHEBI:76932 ! pathway inhibitor

[Term]
id: CHEBI:59635
name: organophosphonate oxoanion
namespace: chebi_ontology
def: "An organic phosphonic acid derivative in which one or more oxygen atoms of the phosphonate group(s) has been deprotonated." []
subset: 3:STAR
synonym: "organophosphonate oxoanions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives

[Term]
id: CHEBI:59644
name: oxo fatty acid
namespace: chebi_ontology
def: "Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group." []
subset: 3:STAR
synonym: "oxo fatty acids" RELATED [chebi]
is_a: CHEBI:25754 ! oxo carboxylic acid
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:59836 ! oxo fatty acid anion

[Term]
id: CHEBI:59647
name: EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of serine palmitoyltransferase (EC 2.3.1.50)." []
subset: 3:STAR
synonym: "3-oxosphinganine synthetase inhibitor" RELATED [chebi]
synonym: "3-oxosphinganine synthetase inhibitors" RELATED [chebi]
synonym: "acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitor" RELATED [chebi]
synonym: "acyl-CoA:serine C-2 acyltransferase (decarboxylating) inhibitors" RELATED [chebi]
synonym: "EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.3.1.50 inhibitor" RELATED [chebi]
synonym: "EC 2.3.1.50 inhibitors" RELATED [chebi]
synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitor" RELATED [chebi]
synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitors" RELATED [chebi]
synonym: "serine C-palmitoyltransferase (EC 2.3.1.50) inhibitor" RELATED [chebi]
synonym: "serine C-palmitoyltransferase (EC 2.3.1.50) inhibitors" RELATED [chebi]
synonym: "serine C-palmitoyltransferase inhibitor" RELATED [chebi]
synonym: "serine C-palmitoyltransferase inhibitors" RELATED [chebi]
synonym: "serine palmitoyltransferase inhibitor" RELATED [chebi]
synonym: "serine palmitoyltransferase inhibitors" RELATED [chebi]
synonym: "SPT inhibitor" RELATED [chebi]
synonym: "SPT inhibitors" RELATED [chebi]
is_a: CHEBI:76878 ! EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor

[Term]
id: CHEBI:59650
name: amino fatty acid
namespace: chebi_ontology
def: "A fatty acid containing at least one amino substituent." []
subset: 3:STAR
synonym: "amino FA" RELATED [chebi]
synonym: "amino fatty acids" RELATED [chebi]
synonym: "carboxylated base" RELATED [chebi]
synonym: "carboxylated bases" RELATED [chebi]
synonym: "lipoamino acid" RELATED [chebi]
synonym: "lipoamino acids" RELATED [chebi]
is_a: CHEBI:32952 ! amine
is_a: CHEBI:33709 ! amino acid
is_a: CHEBI:60690 ! nitrogen-containing fatty acid
relationship: RO:0018034 CHEBI:61007 ! amino fatty acid anion

[Term]
id: CHEBI:59668
name: nikkomycin
namespace: chebi_ontology
def: "A class of nucleoside-peptide antibiotics which inhibit fungal chitin biosynthesis by inhibiting chitin synthase. Generally consist of a heterocyclic moiety (usually a nucleobase), an amino hexuronic acid and an amino acid containing a pyridine ring." []
subset: 3:STAR
synonym: "nikkomycins" RELATED [chebi]
is_a: CHEBI:36988 ! 5'-deoxyribonucleoside
relationship: RO:0000087 CHEBI:25605 ! has role nucleoside antibiotic
relationship: RO:0000087 CHEBI:59672 ! has role EC 2.4.1.16 (chitin synthase) inhibitor

[Term]
id: CHEBI:59672
name: EC 2.4.1.16 (chitin synthase) inhibitor
namespace: chebi_ontology
def: "A EC 2.4.1.* (hexosyltransferase) inhibitor that inhibits the action of chitin synthase (EC 2.4.1.16)." []
subset: 3:STAR
synonym: "chitin synthase (EC 2.4.1.16) inhibitor" RELATED [chebi]
synonym: "chitin synthase (EC 2.4.1.16) inhibitors" RELATED [chebi]
synonym: "chitin synthase inhibitor" RELATED [chebi]
synonym: "chitin synthase inhibitors" RELATED [chebi]
synonym: "chitin synthesis inhibitor" RELATED [chebi]
synonym: "chitin synthesis inhibitors" RELATED [chebi]
synonym: "chitin synthetase inhibitor" RELATED [chebi]
synonym: "chitin synthetase inhibitors" RELATED [chebi]
synonym: "chitin-UDP acetyl-glucosaminyl transferase inhibitor" RELATED [chebi]
synonym: "chitin-UDP acetyl-glucosaminyl transferase inhibitors" RELATED [chebi]
synonym: "chitin-UDP N-acetylglucosaminyltransferase inhibitor" RELATED [chebi]
synonym: "chitin-UDP N-acetylglucosaminyltransferase inhibitors" RELATED [chebi]
synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase inhibitor" RELATED [chebi]
synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.16 (chitin synthase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.16 inhibitor" RELATED [chebi]
synonym: "EC 2.4.1.16 inhibitors" RELATED [chebi]
synonym: "trans-N-acetylglucosaminosylase inhibitor" RELATED [chebi]
synonym: "trans-N-acetylglucosaminosylase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase inhibitors" RELATED [chebi]
is_a: CHEBI:76789 ! EC 2.4.1.* (hexosyltransferase) inhibitor

[Term]
id: CHEBI:59673
name: colistin B
namespace: chebi_ontology
subset: 3:STAR
synonym: "polymyxin E2" RELATED [chebi]
is_a: CHEBI:25903 ! peptide antibiotic
is_a: CHEBI:59062 ! polymyxin

[Term]
id: CHEBI:59676
name: nystatins
namespace: chebi_ontology
def: "A class of polyene antifungal antibiotics produced by <em>Streptomyces noursei</em>, and other <em>Streptomyces</em> species." []
subset: 3:STAR
is_a: CHEBI:22507 ! aminoglycoside antibiotic
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:26191 ! polyol
is_a: CHEBI:36244 ! dicarboxylic acid monoester
is_a: CHEBI:48121 ! polyene
is_a: CHEBI:87113 ! antibiotic antifungal drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:59698
name: phosphoric acids
namespace: chebi_ontology
def: "Compounds containing one or more phosphoric acid units." []
subset: 3:STAR
is_a: CHEBI:33457 ! phosphorus oxoacid

[Term]
id: CHEBI:59740
name: nucleophilic reagent
namespace: chebi_ontology
def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." []
subset: 3:STAR
subset: 3_STAR
synonym: "nucleophile" RELATED [chebi]
synonym: "nucleophile" RELATED [ChEBI]
synonym: "nucleophiles" RELATED [ChEBI]
synonym: "nucleophiles" RELATED [chebi]
synonym: "nucleophilic reagents" RELATED [ChEBI]
synonym: "nucleophilic reagents" RELATED [chebi]
is_a: CHEBI:33893 ! reagent
is_a: CHEBI:39144 ! Lewis base

[Term]
id: CHEBI:59755
name: alpha-amino fatty acid
namespace: chebi_ontology
def: "A fatty acid with an amino substituent at position C-2." []
subset: 3:STAR
synonym: "a-amino fatty acid" RELATED [chebi]
synonym: "a-amino fatty acids" RELATED [chebi]
synonym: "alpha-amino FA" RELATED [chebi]
synonym: "alpha-amino fatty acids" RELATED [chebi]
is_a: CHEBI:59650 ! amino fatty acid
is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid

[Term]
id: CHEBI:59769
name: acetal
namespace: chebi_ontology
def: "An organooxygen compound having the structure RR'C(OR'')(OR''') (R'', R''' ≠ H). Mixed acetals have R'' and R''' groups which differ." []
subset: 3:STAR
synonym: "acetals" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:59770
name: cyclic acetal
namespace: chebi_ontology
def: "An acetal in the molecule of which the acetal carbon and one or both oxygen atoms thereon are members of a ring." []
subset: 3:STAR
synonym: "cyclic acetals" RELATED [chebi]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:59769 ! acetal

[Term]
id: CHEBI:59772
name: hemiketal
namespace: chebi_ontology
def: "A hemiacetal having the structure RR<small><sup>1</small></sup>C(OH)OR<small><sup>2</small></sup> (R, R<small><sup>1</small></sup>, R<small><sup>2</small></sup> ≠ H), derived from a ketone by formal addition of an alcohol to the carbonyl group." []
subset: 3:STAR
synonym: "hemiketals" RELATED [chebi]
is_a: CHEBI:5653 ! hemiacetal

[Term]
id: CHEBI:59777
name: ketal
namespace: chebi_ontology
def: "An acetal of formula R<small><sub>2</sub></small>C(OR)<small><sub>2</sub></small> (R ≠ H) derived from a ketone by replacement of the oxo group by two hydrocarbyloxy groups. The class name 'ketals', once abandoned by IUPAC, has been reinstated as a subclass of acetals." []
subset: 3:STAR
synonym: "ketals" RELATED [chebi]
is_a: CHEBI:59769 ! acetal

[Term]
id: CHEBI:59779
name: cyclic ketal
namespace: chebi_ontology
def: "A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring." []
subset: 3:STAR
synonym: "cyclic ketals" RELATED [chebi]
is_a: CHEBI:38104 ! oxacycle
is_a: CHEBI:59777 ! ketal

[Term]
id: CHEBI:59780
name: cyclic hemiketal
namespace: chebi_ontology
def: "A hemiacetal  having the structure R<small><sub>2</sub></small>C(OH)OR (R ≠ H), derived from a ketone by formal addition of an alcohol to the carbonyl group. The term 'cyclic hemiketals', once abandoned by IUPAC, has been reinstated as a subclass of hemiacetals." []
subset: 3:STAR
synonym: "cyclic hemiketals" RELATED [chebi]
is_a: CHEBI:38131 ! lactol
is_a: CHEBI:59772 ! hemiketal

[Term]
id: CHEBI:59792
name: thioacetal
namespace: chebi_ontology
def: "The sulfur analogue of 'acetal'.  The term includes monothioacetals having the structure R<small><sub>2</sub></small>C(OR')(SR') (subclass monothioketals, R ≠ H); and dithioacetals having the structure R<small><sub>2</sub></small>C(SR')<small><sub>2</sub></small> (subclass dithioketals, R ≠ H, R' ≠ H)." []
subset: 3:STAR
synonym: "thioacetals" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound

[Term]
id: CHEBI:59793
name: monothioacetal
namespace: chebi_ontology
def: "A thioacetal having the structure R<small><sub>2</sub></small>C(OR')(SR'). The term includes monothioketals, R ≠ H, as a subclass." []
subset: 3:STAR
synonym: "monothioacetals" RELATED [chebi]
synonym: "thioacetal" RELATED [chebi]
is_a: CHEBI:59792 ! thioacetal

[Term]
id: CHEBI:59814
name: L-alpha-amino acid anion
namespace: chebi_ontology
def: "Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group." []
subset: 3:STAR
synonym: "L-alpha-amino carboxylate" RELATED [chebi]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:15705 ! L-alpha-amino acid

[Term]
id: CHEBI:59831
name: enyne
namespace: chebi_ontology
def: "An  acetylenic and an olefinic  compound containing a carbon chain that contains a carbon-carbon double bond and a carbon-carbon triple bond." []
subset: 3:STAR
synonym: "enynes" RELATED [chebi]
is_a: CHEBI:73474 ! acetylenic compound
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:59835
name: hydroxy fatty acid anion
namespace: chebi_ontology
def: "The conjugate base of any hydroxy fatty acid, formed by deprotonation of the carboxylic acid moiety." []
subset: 3:STAR
synonym: "hydroxy fatty acid anions" RELATED [chebi]
synonym: "OH-FA anion" RELATED [chebi]
synonym: "OH-FA-anions" RELATED [chebi]
synonym: "OH-fatty acid anion" RELATED [chebi]
synonym: "OH-fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion
relationship: RO:0018033 CHEBI:24654 ! hydroxy fatty acid

[Term]
id: CHEBI:59836
name: oxo fatty acid anion
namespace: chebi_ontology
def: "A fatty acid anion carrying one or more oxo substituents" []
subset: 3:STAR
synonym: "oxo fatty acid anions" RELATED [chebi]
synonym: "oxo-FA anion" RELATED [chebi]
synonym: "oxo-FA anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
is_a: CHEBI:35903 ! oxo carboxylic acid anion
relationship: RO:0018033 CHEBI:59644 ! oxo fatty acid

[Term]
id: CHEBI:59864
name: depigmentation drug
namespace: chebi_ontology
def: "Any drug used to depigment skin, normally by decreasing the excretion of melanin from melanocytes." []
subset: 3:STAR
synonym: "depigmentation agent" RELATED [chebi]
synonym: "depigmentation agents" RELATED [chebi]
synonym: "depigmentation drugs" RELATED [chebi]
synonym: "depigmentor" RELATED [chebi]
synonym: "depigmentors" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:59869
name: L-alpha-amino acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group." []
subset: 3:STAR
synonym: "an L-alpha-amino acid" RELATED [uniprot_ft]
synonym: "L-alpha-amino acid zwitterions" RELATED [chebi]
is_a: CHEBI:78608 ! alpha-amino-acid zwitterion
relationship: RO:0018036 CHEBI:15705 ! L-alpha-amino acid

[Term]
id: CHEBI:59871
name: D-alpha-amino acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group." []
subset: 3:STAR
synonym: "a D-alpha-amino acid" RELATED [uniprot_ft]
synonym: "D-alpha-amino acid zwitterions" RELATED [chebi]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:16733 ! D-alpha-amino acid

[Term]
id: CHEBI:59999
name: chemical substance
namespace: chebi_ontology
def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." []
subset: 3:STAR
synonym: "Chemische Substanz" RELATED [chebi]
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:60004
name: mixture
namespace: chebi_ontology
def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." []
subset: 3:STAR
synonym: "Mischung" RELATED [chebi]
is_a: CHEBI:59999 ! chemical substance

[Term]
id: CHEBI:600103
name: daptomycin
namespace: chebi_ontology
alt_id: CHEBI:29570
alt_id: CHEBI:321017
alt_id: CHEBI:478132
alt_id: CHEBI:478255
def: "A polypeptide comprising <em>N</em>-decanoyltryptophan, asparagine, aspartic acid, threonine, glycine, ornithine, aspartic acid, <small>D</small>-alanine, aspartic acid, glycine, <small>D</small>-serine, <em>threo</em>-3-methylglutamic acid and 3-anthraniloylalanine (also known as kynurinine) coupled in sequence and lactonised by condensation of the carboxylic acid group of the 3-anthraniloylalanine  with the alcohol group of the threonine residue." []
subset: 3:STAR
synonym: "Daptomycin" RELATED [kegg.compound]
synonym: "daptomycin" RELATED [chembl]
synonym: "LY 146032" RELATED [chemidplus]
synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone" RELATED [chebi]
synonym: "N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone" RELATED [chemidplus]
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:25061 ! lipopeptide antibiotic
is_a: CHEBI:25106 ! macrolide
relationship: RO:0000087 CHEBI:140190 ! has role calcium-dependent antibiotics
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:60027
name: polymer
namespace: chebi_ontology
def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." []
subset: 3:STAR
synonym: "Kunststoff" RELATED [chebi]
synonym: "Polymer" RELATED [chebi]
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:33839 ! has part macromolecule

[Term]
id: CHEBI:60039
name: L-proline zwitterion
namespace: chebi_ontology
alt_id: CHEBI:58054
def: "The zwitterion formed from <small>L</small>-proline by proton transfer from the carboxy group to the ring nitrogen. It is the predominant species at physiological pH." []
subset: 3:STAR
synonym: "L-proline" EXACT [UniProt]
synonym: "L-proline" RELATED [uniprot_ft]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:17203 ! L-proline

[Term]
id: CHEBI:600520
name: micafungin
namespace: chebi_ontology
alt_id: CHEBI:473847
alt_id: CHEBI:530001
alt_id: CHEBI:533643
alt_id: CHEBI:533785
def: "A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-β-<small>D</small>-glucan, an integral component of the fungal cell wall. It is used as the sodium salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are intolerant of other therapy." []
subset: 3:STAR
synonym: "Mycamine" RELATED [chemidplus]
is_a: CHEBI:57248 ! echinocandin
is_a: CHEBI:87113 ! antibiotic antifungal drug

[Term]
id: CHEBI:60071
name: ertapenem(1-)
namespace: chebi_ontology
def: "The mono-anion resulting from the removal of a proton from one of the carboxyic acid groups of ertapenem." []
subset: 3:STAR
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:404903 ! ertapenem

[Term]
id: CHEBI:60240
name: divalent metal cation
namespace: chebi_ontology
def: "A metal cation with a valence of two." []
subset: 3:STAR
synonym: "a divalent metal cation" RELATED [uniprot_ft]
is_a: CHEBI:25213 ! metal cation
is_a: CHEBI:64641 ! divalent inorganic cation

[Term]
id: CHEBI:60242
name: monovalent inorganic cation
namespace: chebi_ontology
def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." []
subset: 3:STAR
subset: 3_STAR
synonym: "a monovalent cation" RELATED [UniProt]
synonym: "a monovalent cation" RELATED [uniprot_ft]
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:60251
name: guanidinium ion
namespace: chebi_ontology
def: "R = C or H. The iminium ion resulting from the protonation of one of the imine nitrogens of guanidine or its derivatives." []
subset: 3:STAR
synonym: "diaminomethaniminium ion" RELATED [chebi]
synonym: "diaminomethaniminium ions" RELATED [chebi]
synonym: "guanidinium ions" RELATED [chebi]
is_a: CHEBI:35286 ! iminium ion

[Term]
id: CHEBI:60258
name: EC 3.4.* (hydrolases acting on peptide bond) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:76763
def: "A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*)." []
subset: 3:STAR
synonym: "EC 3.4.* (hydrolase acting on peptide bond) inhibitor" RELATED [chebi]
synonym: "EC 3.4.* (hydrolase acting on peptide bonds) inhibitors" RELATED [chebi]
synonym: "EC 3.4.* (hydrolases acting on peptide bond) inhibitors" RELATED [chebi]
synonym: "EC 3.4.* (peptidase) inhibitor" RELATED [chebi]
synonym: "EC 3.4.* (peptidase) inhibitors" RELATED [chebi]
synonym: "EC 3.4.* inhibitor" RELATED [chebi]
synonym: "EC 3.4.* inhibitors" RELATED [chebi]
synonym: "inhibitor of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [chebi]
synonym: "inhibitors of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [chebi]
synonym: "peptidase inhibitors" RELATED [chebi]
synonym: "protease inhibitor" RELATED [chebi]
synonym: "protease inhibitors" RELATED [chebi]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:6030
name: isoniazide
namespace: chebi_ontology
def: "A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine." []
subset: 3:STAR
synonym: "4-pyridinecarbohydrazide" RELATED [chebi]
synonym: "Isoniazid" RELATED [kegg.compound]
synonym: "isoniazid" RELATED [uniprot_ft]
synonym: "isonicotinic acid hydrazide" RELATED [nist]
synonym: "isonicotinic hydrazide" RELATED [chebi]
synonym: "isonicotinohydrazide" RELATED [nist]
synonym: "isonicotinoylhydrazide" RELATED [iupac]
synonym: "Isonicotinsaeurehydrazid" RELATED [chebi]
synonym: "pyridine-4-carboxylic acid hydrazide" RELATED [chebi]
is_a: CHEBI:35363 ! carbohydrazide
relationship: RO:0000087 CHEBI:33231 ! has role antitubercular agent
relationship: RO:0000087 CHEBI:88188 ! has role drug allergen
relationship: RO:0018038 CHEBI:6032 ! isonicotinic acid

[Term]
id: CHEBI:6032
name: isonicotinic acid
namespace: chebi_ontology
def: "A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring." []
subset: 3:STAR
synonym: "4-carboxypyridine" RELATED [nist]
synonym: "4-pyridinecarboxylic acid" RELATED [nist]
synonym: "gamma-picolinic acid" RELATED [nist]
synonym: "gamma-pyridinecarboxylic acid" RELATED [chemidplus]
synonym: "Isonicotinic acid" RELATED [kegg.compound]
synonym: "p-pyridinecarboxylic acid" RELATED [chemidplus]
is_a: CHEBI:26420 ! pyridinemonocarboxylic acid
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
relationship: RO:0018034 CHEBI:38186 ! isonicotinate

[Term]
id: CHEBI:60334
name: peptide anion
namespace: chebi_ontology
def: "An anion formed by deprotonation of at least one peptide carboxy group." []
subset: 3:STAR
synonym: "peptide anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion

[Term]
id: CHEBI:60466
name: peptide zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." []
subset: 3:STAR
subset: 3_STAR
synonym: "a peptide" RELATED [UniProt]
synonym: "a peptide" RELATED [uniprot_ft]
synonym: "peptide zwitterions" RELATED [ChEBI]
synonym: "peptide zwitterions" RELATED [chebi]
is_a: CHEBI:27369 ! zwitterion
relationship: is_tautomer_of CHEBI:16670 ! peptide
relationship: RO:0018036 CHEBI:16670 ! peptide

[Term]
id: CHEBI:60600
name: amide fungicide
namespace: chebi_ontology
def: "Compounds that contain an amide group as a key feature of their structure and which have been used as fungicides." []
subset: 3:STAR
synonym: "amide fungicides" RELATED [chebi]
is_a: CHEBI:87012 ! amide antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:60643
name: NMDA receptor antagonist
namespace: chebi_ontology
alt_id: CHEBI:60797
def: "Any substance that inhibits the action of <em>N</em>-methyl-<small>D</small>-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs." []
subset: 3:STAR
synonym: "N-methyl-D-aspartate receptor antagonist" RELATED [chebi]
synonym: "N-methyl-D-aspartate receptor antagonists" RELATED [chebi]
synonym: "NMDA receptor antagonists" RELATED [chebi]
synonym: "NMDAR antagonist" RELATED [chebi]
synonym: "NMDAR antagonists" RELATED [chebi]
is_a: CHEBI:60798 ! excitatory amino acid antagonist

[Term]
id: CHEBI:60690
name: nitrogen-containing fatty acid
namespace: chebi_ontology
def: "Any fatty acid containing nitrogen as either a substituent or a replacement for a methylene carbon." []
subset: 3:STAR
synonym: "N-containing fatty acid" RELATED [chebi]
synonym: "N-containing fatty acids" RELATED [chebi]
synonym: "nitrogen-containing fatty acids" RELATED [chebi]
is_a: CHEBI:35366 ! fatty acid
relationship: RO:0018034 CHEBI:61008 ! nitrogen-containing fatty acid anion

[Term]
id: CHEBI:6076
name: itraconazole
namespace: chebi_ontology
def: "An <em>N</em>-arylpiperazine that is <i>cis</i>-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a <em>p</em>-[(±)1-<em>sec</em>-butyl-5-oxo-1,5-dihydro-4<em>H</em>-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis." []
subset: 3:STAR
synonym: "Itraconazole" RELATED [kegg.drug]
synonym: "itraconazole" RELATED [uniprot_ft]
synonym: "Itrizole (TN)" RELATED [kegg.drug]
synonym: "Oriconazole" RELATED [chemidplus]
synonym: "Sporanox (TN)" RELATED [kegg.drug]
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:39430 ! dioxolane
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:59779 ! cyclic ketal
is_a: CHEBI:87071 ! conazole antifungal drug
is_a: CHEBI:87101 ! triazole antifungal drug
relationship: RO:0000087 CHEBI:140921 ! has role Hedgehog signaling pathway inhibitor
relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor
relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor

[Term]
id: CHEBI:60783
name: nucleoside analogue
namespace: chebi_ontology
def: "An analogue of a nucleoside, being an <em>N</em>-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells." []
subset: 3:STAR
synonym: "nucleoside analogues" RELATED [chebi]
is_a: CHEBI:21731 ! N-glycosyl compound

[Term]
id: CHEBI:60798
name: excitatory amino acid antagonist
namespace: chebi_ontology
def: "Any substance which inhibits the action of receptors for excitatory amino acids." []
subset: 3:STAR
synonym: "EAA receptor antagonist" RELATED [chebi]
synonym: "EAA receptor antagonists" RELATED [chebi]
synonym: "excitatory amino acid antagonists" RELATED [chebi]
synonym: "excitatory amino acid receptor antagonist" RELATED [chebi]
synonym: "excitatory amino acid receptor antagonists" RELATED [chebi]
is_a: CHEBI:48706 ! antagonist

[Term]
id: CHEBI:60809
name: adjuvant
namespace: chebi_ontology
def: "Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself." []
subset: 3:STAR
synonym: "adjuvants" RELATED [chebi]
is_a: CHEBI:52217 ! pharmaceutical

[Term]
id: CHEBI:60832
name: tubulin modulator
namespace: chebi_ontology
def: "Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules." []
subset: 3:STAR
synonym: "tubulin modulators" RELATED [chebi]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:60895
name: D-alpha-amino acid anion
namespace: chebi_ontology
def: "Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration." []
subset: 3:STAR
synonym: "D-alpha-amino acid anions" RELATED [chebi]
synonym: "D-alpha-amino carboxylate" RELATED [chebi]
is_a: CHEBI:33558 ! alpha-amino-acid anion
relationship: RO:0018033 CHEBI:16733 ! D-alpha-amino acid

[Term]
id: CHEBI:60911
name: racemate
namespace: chebi_ontology
def: "A racemate is an equimolar mixture of a pair of enantiomers." []
subset: 3:STAR
synonym: "melange racemique" RELATED [chebi]
synonym: "racemates" RELATED [chebi]
synonym: "racemic mixture" RELATED [chebi]
is_a: CHEBI:60004 ! mixture

[Term]
id: CHEBI:60915
name: diastereoisomeric mixture
namespace: chebi_ontology
def: "A mixture composed of two or more diastereoisomers (stereoisomers not related as mirror images)." []
subset: 3:STAR
synonym: "diastereomeric mixture" RELATED [chebi]
is_a: CHEBI:60004 ! mixture

[Term]
id: CHEBI:60926
name: amino monosaccharide
namespace: chebi_ontology
def: "Any  amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." []
subset: 3:STAR
synonym: "amino monosaccharides" RELATED [chebi]
is_a: CHEBI:28963 ! amino sugar

[Term]
id: CHEBI:60979
name: alpha-glucoside
namespace: chebi_ontology
def: "A glucoside in which the anomeric carbon of the glycosidic bond is in an α configuration" []
subset: 3:STAR
synonym: "alpha-glucosides" RELATED [chebi]
is_a: CHEBI:24278 ! glucoside

[Term]
id: CHEBI:61007
name: amino fatty acid anion
namespace: chebi_ontology
def: "A nitrogen-containing fatty acid anion arising from deprotonation of the carboxy group of any amino fatty acid." []
subset: 3:STAR
synonym: "amino FA anion" RELATED [chebi]
synonym: "amino FA anions" RELATED [chebi]
synonym: "amino fatty acid anions" RELATED [chebi]
synonym: "NH2-FA anion" RELATED [chebi]
synonym: "NH2-FA anions" RELATED [chebi]
synonym: "NH2-fatty acid anion" RELATED [chebi]
synonym: "NH2-fatty acid anions" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
is_a: CHEBI:61008 ! nitrogen-containing fatty acid anion
relationship: RO:0018033 CHEBI:59650 ! amino fatty acid

[Term]
id: CHEBI:61008
name: nitrogen-containing fatty acid anion
namespace: chebi_ontology
def: "A fatty acid anion arising from deprotonation of the carboxylic acid group of any nitrogen-containing fatty acid." []
subset: 3:STAR
synonym: "N-containing FA anion" RELATED [chebi]
synonym: "N-containing FA anions" RELATED [chebi]
synonym: "N-containing fatty acid anions" RELATED [chebi]
synonym: "nitrogen-containing FA anion" RELATED [chebi]
synonym: "nitrogen-containing FA anions" RELATED [chebi]
synonym: "nitrogen-containing fatty acid anion" RELATED [chebi]
synonym: "nitrogen-containing fatty acid anions" RELATED [chebi]
is_a: CHEBI:28868 ! fatty acid anion
relationship: RO:0018033 CHEBI:60690 ! nitrogen-containing fatty acid

[Term]
id: CHEBI:61115
name: EC 3.5.1.98 (histone deacetylase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98)." []
subset: 3:STAR
synonym: "EC 3.5.1.98 (histone deacetylase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.98 inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.98 inhibitors" RELATED [chebi]
synonym: "HDAC inhibitor" RELATED [chebi]
synonym: "HDAC inhibitors" RELATED [chebi]
synonym: "HDACi" RELATED [chebi]
synonym: "HDACis" RELATED [chebi]
synonym: "HDI" RELATED [chebi]
synonym: "HDIs" RELATED [chebi]
synonym: "histone amidohydrolase inhibitor" RELATED [chebi]
synonym: "histone amidohydrolase inhibitors" RELATED [chebi]
synonym: "histone deacetylase (EC 3.5.1.98) inhibitor" RELATED [chebi]
synonym: "histone deacetylase (EC 3.5.1.98) inhibitors" RELATED [chebi]
synonym: "histone deacetylase inhibitor" RELATED [chebi]
synonym: "histone deacetylase inhibitors" RELATED [chebi]
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:61120
name: nucleobase-containing molecular entity
namespace: chebi_ontology
def: "Any compound that has a nucleobase as a part." []
subset: 3:STAR
subset: 3_STAR
synonym: "nucleobase-containing compound" RELATED [SUBMITTER]
synonym: "nucleobase-containing compound" RELATED [submitter]
synonym: "nucleobase-containing compounds" RELATED [ChEBI]
synonym: "nucleobase-containing compounds" RELATED [chebi]
synonym: "nucleobase-containing molecular entities" RELATED [chebi]
synonym: "nucleobase-containing molecular entities" RELATED [ChEBI]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: has_functional_parent CHEBI:18282 ! nucleobase
relationship: RO:0018038 CHEBI:18282 ! nucleobase

[Term]
id: CHEBI:61293
name: adenyl nucleotide
namespace: chebi_ontology
def: "A  nucleotide having adenine as the base." []
subset: 3:STAR
is_a: CHEBI:26395 ! purine nucleotide

[Term]
id: CHEBI:61296
name: adenyl ribonucleotide
namespace: chebi_ontology
def: "A purine riboncleotide where adenine is the purine." []
subset: 3:STAR
synonym: "adenine ribonucleotide" RELATED [submitter]
is_a: CHEBI:26400 ! purine ribonucleotide
is_a: CHEBI:61293 ! adenyl nucleotide

[Term]
id: CHEBI:61689
name: amino cyclitol
namespace: chebi_ontology
def: "Any cyclitol having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." []
subset: 3:STAR
synonym: "amino cyclitols" RELATED [chebi]
synonym: "aminocyclitol" RELATED [chebi]
synonym: "aminocyclitols" RELATED [chebi]
is_a: CHEBI:23451 ! cyclitol

[Term]
id: CHEBI:61739
name: aureobasidin A
namespace: chebi_ontology
def: "A cyclodepsipeptide antibiotic, which is isolated from the filamentous fungus <em>Aureobasidium pullulans</em> R106 and is toxic to yeast at low concentrations (0.1-0.5 ug/ml)." []
subset: 3:STAR
synonym: "(3S,6S,9S,12S,15S,18S,21S,24R,27S)-12,24-bis[(2R)-butan-2-yl]-15-(2-hydroxypropan-2-yl)-4,10,16,22-tetramethyl-18-(2-methylpropyl)-3,6-bis(phenylmethyl)-9,21-di(propan-2-yl)-13-oxa-1,4,7,10,16,19,22,25-octazabicyclo[25.3.0]triacontane-2,5,8,11,14,17,20,23,26-nonone" RELATED [submitter]
synonym: "Antibiotic R106I" RELATED [chebi]
synonym: "N-((2R,3R)-2-hydroxy-3-methylvaleryl)-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl-L- alloisoleucyl-N-methyl-L-valyl-L-leucyl-3-hydroxy-N-methyl- L-valine alpha1-lactone" RELATED [chemidplus]
is_a: CHEBI:25903 ! peptide antibiotic
is_a: CHEBI:35213 ! cyclodepsipeptide
relationship: RO:0000087 CHEBI:61774 ! has role inositol phosphorylceramide synthase inhibitor

[Term]
id: CHEBI:61774
name: inositol phosphorylceramide synthase inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that inhibits the action of inositol phosphorylceramide synthase." []
subset: 3:STAR
is_a: CHEBI:76881 ! EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor

[Term]
id: CHEBI:61951
name: microtubule-destabilising agent
namespace: chebi_ontology
def: "Any substance that interacts with tubulin to inhibit polymerisation of microtubules." []
subset: 3:STAR
synonym: "microtubule destabilising agent" RELATED [chebi]
synonym: "microtubule destabilising agents" RELATED [chebi]
synonym: "microtubule destabilising role" RELATED [chebi]
synonym: "microtubule destabilizing role" RELATED [submitter]
synonym: "microtubule-destabilising agents" RELATED [chebi]
synonym: "microtubule-destabilizing agent" RELATED [chebi]
synonym: "microtubule-destabilizing agents" RELATED [chebi]
is_a: CHEBI:60832 ! tubulin modulator
is_a: CHEBI:64911 ! antimitotic

[Term]
id: CHEBI:62031
name: polar amino acid zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group." []
subset: 2:STAR
synonym: "a polar amino acid" RELATED [uniprot_ft]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:26167 ! polar amino acid

[Term]
id: CHEBI:62070
name: nalidixic acid anion
namespace: chebi_ontology
def: "A monocarboxylic acid anion that is the conjugate base of nalidixic acid; major species at pH 7.3." []
subset: 3:STAR
synonym: "nalidixate" RELATED [chebi]
synonym: "nalidixate anion" RELATED [chebi]
synonym: "nalidixate(1-)" RELATED [chebi]
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: RO:0018033 CHEBI:100147 ! nalidixic acid

[Term]
id: CHEBI:62220
name: pyocyanine(1+)
namespace: chebi_ontology
def: "An organic cation resulting from the protonation of pyocyanin." []
subset: 3:STAR
synonym: "5-methylphenazin-1(5H)-one" RELATED [metacyc.compound]
synonym: "pyocyanin" RELATED [uniprot_ft]
synonym: "pyocyanin(1+)" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:39201 ! phenazines
relationship: RO:0018034 CHEBI:8653 ! pyocyanine

[Term]
id: CHEBI:62247
name: (1R,2S)-epoxypropylphosphonate(1-)
namespace: chebi_ontology
def: "An organophosphonate oxoanion obtained by deprotonation of one of the two phosphonate OH groups of (1<i>R</i>,2<i>S</i>)-epoxypropylphosphonic acid; major species at pH 7.3." []
subset: 3:STAR
synonym: "(1R,2S)-epoxypropylphosphonate" RELATED [uniprot_ft]
synonym: "fosfomycin(1-)" RELATED [chebi]
is_a: CHEBI:59635 ! organophosphonate oxoanion
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0018033 CHEBI:28915 ! fosfomycin
relationship: RO:0018034 CHEBI:62419 ! (1R,2S)-epoxypropylphosphonate(2-)

[Term]
id: CHEBI:623918
name: nikkomycin Z
namespace: chebi_ontology
alt_id: CHEBI:109145
alt_id: CHEBI:621961
def: "A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase." []
subset: 3:STAR
synonym: "(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-beta-D-allo-furanuronic acid" RELATED [chebi]
synonym: "(2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]acetic acid" RELATED [chebi]
synonym: "Neopolyoxin C" RELATED [chemidplus]
synonym: "Nikkomycin" RELATED [chemidplus]
is_a: CHEBI:59668 ! nikkomycin
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0018038 CHEBI:16704 ! uridine

[Term]
id: CHEBI:62419
name: (1R,2S)-epoxypropylphosphonate(2-)
namespace: chebi_ontology
def: "An organophosphonate oxoanion obtained by deprotonation of the two phosphonate OH groups of (1<i>R</i>,2<i>S</i>)-epoxypropylphosphonic acid." []
subset: 3:STAR
synonym: "(1R,2S)-epoxypropylphosphonate" RELATED [chebi]
synonym: "(1R,2S)-epoxypropylphosphonate dianion" RELATED [chebi]
synonym: "fosfomycin" RELATED [chebi]
synonym: "fosfomycin dianion" RELATED [chebi]
synonym: "fosfomycin(2-)" RELATED [chebi]
is_a: CHEBI:71285 ! organophosphonate(2-)
relationship: RO:0018033 CHEBI:62247 ! (1R,2S)-epoxypropylphosphonate(1-)

[Term]
id: CHEBI:62488
name: signalling molecule
namespace: chebi_ontology
def: "A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell." []
subset: 3:STAR
synonym: "signal molecule" RELATED [chebi]
synonym: "signal molecules" RELATED [chebi]
synonym: "signaling molecule" RELATED [chebi]
synonym: "signaling molecules" RELATED [chebi]
synonym: "signalling molecules" RELATED [chebi]
is_a: CHEBI:33280 ! molecular messenger

[Term]
id: CHEBI:62643
name: anionic phospholipid
namespace: chebi_ontology
def: "Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1−), phosphatidate(2−), phosphatidylglycerol(1−)." []
subset: 3:STAR
synonym: "anionic phospholipids" RELATED [chebi]
synonym: "phospholipid anion" RELATED [chebi]
synonym: "phospholipid anions" RELATED [chebi]
is_a: CHEBI:58945 ! organophosphate oxoanion
relationship: RO:0018033 CHEBI:16247 ! phospholipid

[Term]
id: CHEBI:62733
name: aromatic amide
namespace: chebi_ontology
def: "An amide in which the amide linkage is bonded directly to an aromatic system." []
subset: 3:STAR
synonym: "aromatic amides" RELATED [chebi]
is_a: CHEBI:32988 ! amide
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:62868
name: hepatoprotective agent
namespace: chebi_ontology
def: "Any compound that is able to prevent damage to the liver." []
subset: 3:STAR
synonym: "antihepatotoxic agent" RELATED [chebi]
synonym: "hepatoprotective agents" RELATED [chebi]
synonym: "hepatoprotector" RELATED [chebi]
is_a: CHEBI:50267 ! protective agent

[Term]
id: CHEBI:62872
name: EC 1.2.3.1 (aldehyde oxidase) inhibitor
namespace: chebi_ontology
def: "An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1)." []
subset: 3:STAR
synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitor" RELATED [chebi]
synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitors" RELATED [chebi]
synonym: "aldehyde oxidase inhibitor" RELATED [chebi]
synonym: "aldehyde oxidase inhibitors" RELATED [chebi]
synonym: "aldehyde:oxygen oxidoreductase inhibitor" RELATED [chebi]
synonym: "aldehyde:oxygen oxidoreductase inhibitors" RELATED [chebi]
synonym: "EC 1.2.3.1 (aldehyde oxidase) inhibitors" RELATED [chebi]
synonym: "EC 1.2.3.1 inhibitor" RELATED [chebi]
synonym: "EC 1.2.3.1 inhibitors" RELATED [chebi]
synonym: "quinoline oxidase inhibitor" RELATED [chebi]
synonym: "quinoline oxidase inhibitors" RELATED [chebi]
synonym: "retinal oxidase inhibitor" RELATED [chebi]
synonym: "retinal oxidase inhibitors" RELATED [chebi]
synonym: "retinoic acid synthase inhibitor" RELATED [chebi]
synonym: "retinoic acid synthase inhibitors" RELATED [chebi]
is_a: CHEBI:76853 ! EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor

[Term]
id: CHEBI:62913
name: EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of a NAD<small><sup>+</small></sup> ADP-ribosyltransferase (EC 2.4.2.30)." []
subset: 3:STAR
synonym: "ADP-ribosyltransferase (polymerising) inhibitor" RELATED [chebi]
synonym: "ADP-ribosyltransferase (polymerising) inhibitors" RELATED [chebi]
synonym: "ADP-ribosyltransferase (polymerizing) inhibitor" RELATED [chebi]
synonym: "ADP-ribosyltransferase (polymerizing) inhibitors" RELATED [chebi]
synonym: "EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.2.30 inhibitor" RELATED [chebi]
synonym: "EC 2.4.2.30 inhibitors" RELATED [chebi]
synonym: "NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitor" RELATED [chebi]
synonym: "NAD(+) ADP-ribosyltransferase (EC 2.4.2.30) inhibitors" RELATED [chebi]
synonym: "NAD(+) ADP-ribosyltransferase inhibitor" RELATED [chebi]
synonym: "NAD(+) ADP-ribosyltransferase inhibitors" RELATED [chebi]
synonym: "NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor" RELATED [chebi]
synonym: "NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors" RELATED [chebi]
synonym: "NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitor" RELATED [chebi]
synonym: "NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors" RELATED [chebi]
synonym: "PARP" RELATED [chebi]
synonym: "PARPs" RELATED [chebi]
synonym: "poly(adenosine diphosphate ribose) polymerase inhibitor" RELATED [chebi]
synonym: "poly(adenosine diphosphate ribose) polymerase inhibitors" RELATED [chebi]
synonym: "poly(ADP-ribose) polymerase inhibitor" RELATED [chebi]
synonym: "poly(ADP-ribose) polymerase inhibitors" RELATED [chebi]
synonym: "poly(ADP-ribose) synthase inhibitor" RELATED [chebi]
synonym: "poly(ADP-ribose) synthase inhibitors" RELATED [chebi]
synonym: "poly(ADP-ribose) synthetase inhibitor" RELATED [chebi]
synonym: "poly(ADP-ribose) synthetase inhibitors" RELATED [chebi]
is_a: CHEBI:76790 ! EC 2.4.2.* (pentosyltransferase) inhibitor

[Term]
id: CHEBI:63046
name: emulsifier
namespace: chebi_ontology
def: "The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability." []
subset: 3:STAR
synonym: "emulgent" RELATED [chebi]
synonym: "emulgents" RELATED [chebi]
synonym: "emulsifiers" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63161
name: glycosyl compound
namespace: chebi_ontology
def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." []
subset: 3:STAR
synonym: "glycosyl compounds" RELATED [chebi]
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:63247
name: reducing agent
namespace: chebi_ontology
def: "The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species." []
subset: 3:STAR
synonym: "reducer" RELATED [chebi]
synonym: "reducers" RELATED [chebi]
synonym: "reducing agents" RELATED [chebi]
synonym: "reductant" RELATED [chebi]
synonym: "reductants" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63248
name: oxidising agent
namespace: chebi_ontology
def: "A substance that removes electrons from another reactant in a redox reaction." []
subset: 3:STAR
synonym: "oxidant" RELATED [chebi]
synonym: "oxidants" RELATED [chebi]
synonym: "oxidiser" RELATED [chebi]
synonym: "oxidisers" RELATED [chebi]
synonym: "oxidising agents" RELATED [chebi]
synonym: "oxidizer" RELATED [chebi]
synonym: "oxidizers" RELATED [chebi]
synonym: "oxidizing agent" RELATED [chebi]
synonym: "oxidizing agents" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63299
name: carbohydrate derivative
namespace: chebi_ontology
def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." []
subset: 3:STAR
synonym: "carbohydrate derivatives" RELATED [chebi]
synonym: "derivatised carbohydrate" RELATED [chebi]
synonym: "derivatised carbohydrates" RELATED [chebi]
synonym: "derivatized carbohydrate" RELATED [chebi]
synonym: "derivatized carbohydrates" RELATED [chebi]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
relationship: RO:0018038 CHEBI:16646 ! carbohydrate

[Term]
id: CHEBI:63353
name: disaccharide derivative
namespace: chebi_ontology
def: "A carbohydrate derivative that is formally obtained from a disaccharide." []
subset: 3:STAR
synonym: "disaccharide derivatives" RELATED [chebi]
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0018038 CHEBI:36233 ! disaccharide

[Term]
id: CHEBI:63367
name: monosaccharide derivative
namespace: chebi_ontology
def: "A carbohydrate derivative that is formally obtained from a monosaccharide." []
subset: 3:STAR
synonym: "monosaccharide derivatives" RELATED [chebi]
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0018038 CHEBI:35381 ! monosaccharide

[Term]
id: CHEBI:63409
name: pentose derivative
namespace: chebi_ontology
def: "A monosaccharide derivative that is formally obtained from a pentose." []
subset: 3:STAR
synonym: "pentose derivatives" RELATED [chebi]
is_a: CHEBI:63367 ! monosaccharide derivative
relationship: RO:0018038 CHEBI:25901 ! pentose

[Term]
id: CHEBI:63473
name: aromatic amino-acid anion
namespace: chebi_ontology
def: "An aromatic amino acid whose α-carboxylic acid group is ionized (non-protonated)." []
subset: 3:STAR
synonym: "aromatic amino-acid anions" RELATED [chebi]
is_a: CHEBI:37022 ! amino-acid anion
relationship: RO:0018033 CHEBI:33856 ! aromatic amino acid

[Term]
id: CHEBI:63490
name: explosive
namespace: chebi_ontology
def: "A substance capable of undergoing rapid and highly exothermic decomposition." []
subset: 3:STAR
synonym: "explosive compound" RELATED [chebi]
synonym: "explosive compounds" RELATED [chebi]
synonym: "explosive material" RELATED [chebi]
synonym: "explosives" RELATED [chebi]
synonym: "explosives chemical" RELATED [chebi]
synonym: "explosives chemicals" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63598
name: levofloxacin
namespace: chebi_ontology
alt_id: CHEBI:6440
def: "An optically active form of ofloxacin having (<i>S</i>)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase." []
subset: 3:STAR
synonym: "(-)-Ofloxacin" RELATED [chemidplus]
synonym: "(-)-ofloxacin" RELATED [chebi]
synonym: "(3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid" RELATED [chebi]
synonym: "(S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid" RELATED [chebi]
synonym: "(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid" RELATED [chemidplus]
synonym: "(S)-ofloxacin" RELATED [chemidplus]
synonym: "DR 3355" RELATED [chebi]
synonym: "DR-3355" RELATED [chebi]
synonym: "L-ofloxacin" RELATED [drugbank]
synonym: "Ofloxacin S-(-)-form" RELATED [kegg.compound]
synonym: "S-(-)-ofloxacin" RELATED [chebi]
is_a: CHEBI:194135 ! 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0018034 CHEBI:231553 ! levofloxacin(1-)
relationship: RO:0018039 CHEBI:46577 ! dextrofloxacin

[Term]
id: CHEBI:63607
name: linezolid
namespace: chebi_ontology
alt_id: CHEBI:6477
def: "An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an <em>N</em>-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex." []
subset: 3:STAR
synonym: "Linezolid" RELATED [kegg.compound]
synonym: "N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide" RELATED [chemidplus]
is_a: CHEBI:22160 ! acetamides
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:38785 ! morpholines
is_a: CHEBI:55374 ! oxazolidinone
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor

[Term]
id: CHEBI:63611
name: moxifloxacin
namespace: chebi_ontology
alt_id: CHEBI:7007
def: "A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4a<i>S</i>,7a<i>S</i>)-octahydro-6<em>H</em>-pyrrolo[3,4-<em>b</em>]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents." []
subset: 3:STAR
synonym: "1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid" RELATED [chemidplus]
synonym: "Moxifloxacin" RELATED [kegg.compound]
is_a: CHEBI:23765 ! quinolone
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:51454 ! cyclopropanes
is_a: CHEBI:63697 ! pyrrolidinopiperidine
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018033 CHEBI:63699 ! moxifloxacinium(1+)

[Term]
id: CHEBI:63673
name: chemokine receptor 5 antagonist
namespace: chebi_ontology
def: "An antogonist that blocks chemokine receptor 5 (CCR5)." []
subset: 3:STAR
synonym: "C-C chemokine receptor 5 antagonist" RELATED [chebi]
synonym: "C-C chemokine receptor 5 antagonists" RELATED [chebi]
synonym: "CCR-5 antagonist" RELATED [chebi]
synonym: "CCR-5 antagonists" RELATED [chebi]
synonym: "CCR5 antagonist" RELATED [chebi]
synonym: "CCR5 antagonists" RELATED [chebi]
synonym: "chemokine receptor 5 antagonists" RELATED [chebi]
is_a: CHEBI:48706 ! antagonist

[Term]
id: CHEBI:63697
name: pyrrolidinopiperidine
namespace: chebi_ontology
def: "Any organic heterobicyclic compound containing <em>ortho</em>-fused pyrrolidine and piperidine rings." []
subset: 3:STAR
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:63699
name: moxifloxacinium(1+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of moxifloxacin." []
subset: 3:STAR
synonym: "moxifloxacin cation" RELATED [chebi]
synonym: "moxifloxacin(1+)" RELATED [chebi]
synonym: "moxifloxacinium" RELATED [chebi]
synonym: "moxifloxacinium cation" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:63611 ! moxifloxacin

[Term]
id: CHEBI:63726
name: neuroprotective agent
namespace: chebi_ontology
def: "Any compound that can be used for the treatment of neurodegenerative disorders." []
subset: 3:STAR
synonym: "neuroprotectant" RELATED [chebi]
synonym: "neuroprotectants" RELATED [chebi]
synonym: "neuroprotective agents" RELATED [chebi]
is_a: CHEBI:50267 ! protective agent

[Term]
id: CHEBI:63944
name: macrocyclic lactone
namespace: chebi_ontology
alt_id: CHEBI:50333
def: "Any lactone in which the cyclic carboxylic ester group forms a part of a cyclic macromolecule." []
subset: 3:STAR
synonym: "macrocyclic lactones" RELATED [chebi]
is_a: CHEBI:25000 ! lactone
is_a: CHEBI:51026 ! macrocycle

[Term]
id: CHEBI:63951
name: estrogen receptor agonist
namespace: chebi_ontology
def: "An agonist at the estrogen receptor." []
subset: 3:STAR
synonym: "estrogen receptor agonists" RELATED [chebi]
is_a: CHEBI:48705 ! agonist

[Term]
id: CHEBI:64047
name: food additive
namespace: chebi_ontology
def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." []
subset: 3:STAR
synonym: "food additives" RELATED [chebi]
is_a: CHEBI:747325 ! additive
is_a: CHEBI:78295 ! food component

[Term]
id: CHEBI:64049
name: food acidity regulator
namespace: chebi_ontology
def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." []
subset: 3:STAR
synonym: "acidity regulator" RELATED [chebi]
synonym: "acidity regulators" RELATED [chebi]
synonym: "food acidity regulators" RELATED [chebi]
synonym: "pH control agent" RELATED [chebi]
synonym: "pH control agents" RELATED [chebi]
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:64130
name: pyrazinoindole
namespace: chebi_ontology
def: "An organic heterotricyclic compound comprising a pyrazine ring fused to an indole ring system." []
subset: 3:STAR
synonym: "pyrazinoindoles" RELATED [chebi]
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:64133
name: EC 2.5.1.58 (protein farnesyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein farnesyltransferase (EC 2.5.1.58), one of the three enzymes in the prenyltransferase group." []
subset: 3:STAR
synonym: "EC 2.5.1.58 (protein farnesyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.5.1.58 inhibitor" RELATED [chebi]
synonym: "EC 2.5.1.58 inhibitors" RELATED [chebi]
synonym: "farnesyl transferase inhibitor" RELATED [chebi]
synonym: "farnesyl transferase inhibitors" RELATED [chebi]
synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitor" RELATED [chebi]
synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors" RELATED [chebi]
synonym: "farnesyltransferase inhibitor" RELATED [chebi]
synonym: "farnesyltransferase inhibitors" RELATED [chebi]
synonym: "FTase inhibitor" RELATED [chebi]
synonym: "FTase inhibitors" RELATED [chebi]
synonym: "protein farnesyltransferase (EC 2.5.1.58) inhibitor" RELATED [chebi]
synonym: "protein farnesyltransferase (EC 2.5.1.58) inhibitors" RELATED [chebi]
synonym: "protein farnesyltransferase inhibitor" RELATED [chebi]
synonym: "protein farnesyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor

[Term]
id: CHEBI:64228
name: tunicamycin A0
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by an 11-methyldodec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "tunicamycin I" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64237
name: EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor that interferes with the action of any UDP-<em>N</em>-acetylglucosamine—dolichyl-phosphate <em>N</em>-acetylglucosaminephosphotransferase (EC 2.7.8.15), preventing formation of <em>N</em>-acetylglucosamine lipid intermediates and glycosylation of newly synthesised glycoproteins." []
subset: 3:STAR
synonym: "chitobiosylpyrophosphoryldolichol synthase inhibitor" RELATED [chebi]
synonym: "chitobiosylpyrophosphoryldolichol synthase inhibitors" RELATED [chebi]
synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitor" RELATED [chebi]
synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase inhibitors" RELATED [chebi]
synonym: "EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.8.15 inhibitor" RELATED [chebi]
synonym: "EC 2.7.8.15 inhibitors" RELATED [chebi]
synonym: "GlcNAc-1-P transferase inhibitor" RELATED [chebi]
synonym: "GlcNAc-1-P transferase inhibitors" RELATED [chebi]
synonym: "N-acetylglucosamine phosphotransferase inhibitor" RELATED [chebi]
synonym: "N-acetylglucosamine transferase inhibitors" RELATED [chebi]
synonym: "N-acetylglucosamine-1-phosphate transferase inhibitor" RELATED [chebi]
synonym: "N-acetylglucosamine-1-phosphate transferase inhibitors" RELATED [chebi]
synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitor" RELATED [chebi]
synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine phosphotransferase inhibitors" RELATED [chebi]
synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitor" RELATED [chebi]
synonym: "UDP-acetylglucosamine--dolichol phosphate acetylglucosamine-1-phosphotransferase inhibitors" RELATED [chebi]
synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitor" RELATED [chebi]
synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase inhibitors" RELATED [chebi]
synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitor" RELATED [chebi]
synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitor" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) inhibitors" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase inhibitors" RELATED [chebi]
synonym: "uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitor" RELATED [chebi]
synonym: "uridine diphosphoacetylglucosamine--dolichyl phosphate acetylglucosamine-1-phosphotransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76816 ! EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor

[Term]
id: CHEBI:64245
name: tunicamycin A1
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 12-methyltridec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "tunicamycin A(1)" RELATED [uniprot_ft]
synonym: "tunicamycin C" RELATED [chebi]
synonym: "tunicamycin II" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64246
name: tunicamycin A2
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a tetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "tunicamycin III" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64248
name: tunicamycin B1
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a pentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "tunicamycin IV" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64250
name: tunicamycin B2
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 13-methyltetradec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "tunicamycin A" RELATED [chebi]
synonym: "tunicamycin V" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64255
name: tunicamycin B3
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by an 13-methyltetradecanoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "tunicamycin VI" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64256
name: tunicamycin C1
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 14-methylpentadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
synonym: "corynetoxin U-16I" RELATED [chemidplus]
synonym: "tunicamycin B" RELATED [chebi]
synonym: "tunicamycin VII" RELATED [chebi]
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0000087 CHEBI:76507 ! has role marine metabolite
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:64257
name: tunicamycin C2
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a hexadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64268
name: erythromycin A(1+)
namespace: chebi_ontology
def: "An erythromycin cation that is the conjugate acid of erythromycin A, arising from protonation of the tertiary amino group on the 3,4,6-trideoxy-3-(dimethylamino)-β-<small>D</small>-<i>xylo</i>-hexopyranosyl residue; major species at pH 7.3." []
subset: 3:STAR
synonym: "erythromycin A" RELATED [uniprot_ft]
synonym: "erythromycin A cation" RELATED [chebi]
is_a: CHEBI:64290 ! erythromycin cation
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018034 CHEBI:42355 ! erythromycin A

[Term]
id: CHEBI:64271
name: tunicamycin D1
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a heptadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64272
name: tunicamycin D2
namespace: chebi_ontology
def: "A nucleoside that is one of the homologues in the mixture that is tunicamycin, characterised by a 15-methylhexadec-2-enoyl fatty acyl substituent on the amino group of the tunicamine moiety." []
subset: 3:STAR
is_a: CHEBI:33838 ! nucleoside
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:64290
name: erythromycin cation
namespace: chebi_ontology
def: "An organic cation obtained by protonation of any erythromycin." []
subset: 3:STAR
synonym: "erythromycin cation" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018033 CHEBI:48923 ! erythromycin

[Term]
id: CHEBI:64355
name: posaconazole
namespace: chebi_ontology
def: "An <em>N</em>-arylpiperazine that consists of piperazine carrying two 4-substituted phenyl groups at positions 1 and 4. A triazole antifungal drug." []
subset: 3:STAR
synonym: "posaconazole" RELATED [uniprot_ft]
synonym: "Sch 56592" RELATED [chemidplus]
synonym: "SCH56592" RELATED [chebi]
synonym: "Schering 56592" RELATED [chebi]
is_a: CHEBI:26912 ! oxolanes
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:87071 ! conazole antifungal drug
is_a: CHEBI:87101 ! triazole antifungal drug
relationship: RO:0000087 CHEBI:36335 ! has role trypanocidal drug

[Term]
id: CHEBI:64383
name: pentamidinium(2+)
namespace: chebi_ontology
def: "A carboxamidinium ion obtained by protonation of both amindino groups of pentamidine." []
subset: 3:STAR
synonym: "pentamidine dication" RELATED [chebi]
synonym: "pentamidine(2+)" RELATED [chebi]
synonym: "pentamidinium cation" RELATED [chebi]
synonym: "pentamidinium dication" RELATED [chebi]
is_a: CHEBI:77718 ! carboxamidinium ion
relationship: RO:0018034 CHEBI:45081 ! pentamidine

[Term]
id: CHEBI:64459
name: biaryl
namespace: chebi_ontology
def: "An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond." []
subset: 3:STAR
synonym: "biaryls" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:64571
name: NMDA receptor agonist
namespace: chebi_ontology
def: "An excitatory amino acid agonist which binds to NMDA receptors and triggers a response." []
subset: 3:STAR
synonym: "N-methyl-D-aspartate receptor agonist" RELATED [chebi]
synonym: "N-methyl-D-aspartate receptor agonists" RELATED [chebi]
synonym: "NMDA receptor agonists" RELATED [chebi]
synonym: "NMDAR agonist" RELATED [chebi]
synonym: "NMDAR agonists" RELATED [chebi]
is_a: CHEBI:50103 ! excitatory amino acid agonist

[Term]
id: CHEBI:64577
name: flour treatment agent
namespace: chebi_ontology
def: "A food additive which is added to flour or dough to improve baking quality and/or colour." []
subset: 3:STAR
synonym: "dough improver" RELATED [chebi]
synonym: "dough improvers" RELATED [chebi]
synonym: "flour treatment agent" RELATED [chebi]
synonym: "improving agent" RELATED [chebi]
synonym: "improving agents" RELATED [chebi]
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:64641
name: divalent inorganic cation
namespace: chebi_ontology
def: "An inorganic cation with a valency of two." []
subset: 3:STAR
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:64708
name: one-carbon compound
namespace: chebi_ontology
def: "An organic molecular entity containing a single carbon atom (C1)." []
subset: 3:STAR
subset: 3_STAR
synonym: "one-carbon compounds" RELATED [chebi]
synonym: "one-carbon compounds" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:64709
name: organic acid
namespace: chebi_ontology
def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic acids" RELATED [chebi]
synonym: "organic acids" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:6472
name: lincomycin
namespace: chebi_ontology
def: "A carbohydrate-containing antibiotic produced by the actinomyces <em>Streptomyces lincolnensis</em>." []
subset: 3:STAR
synonym: "Cillimycin" RELATED [chemidplus]
synonym: "Lincomycin" RELATED [kegg.compound]
synonym: "Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside" RELATED [nist]
is_a: CHEBI:23007 ! carbohydrate-containing antibiotic
is_a: CHEBI:35275 ! S-glycosyl compound
is_a: CHEBI:46770 ! pyrrolidinecarboxamide
is_a: CHEBI:84186 ! L-proline derivative
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:64766
name: cationic group
namespace: chebi_ontology
def: "A group that carries an overall positive charge." []
subset: 3:STAR
subset: 3_STAR
synonym: "cationic groups" RELATED [ChEBI]
synonym: "cationic groups" RELATED [chebi]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:64767
name: anionic group
namespace: chebi_ontology
def: "A group that carries an overall negative charge." []
subset: 3:STAR
subset: 3_STAR
synonym: "anionic groups" RELATED [chebi]
synonym: "anionic groups" RELATED [ChEBI]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:64769
name: organic cationic group
namespace: chebi_ontology
def: "A cationic group that contains carbon." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic cationic groups" RELATED [ChEBI]
synonym: "organic cationic groups" RELATED [chebi]
is_a: CHEBI:64766 ! cationic group
relationship: is_conjugate_acid_of CHEBI:33247 ! organic group
relationship: RO:0018034 CHEBI:33247 ! organic group

[Term]
id: CHEBI:64775
name: organic anionic group
namespace: chebi_ontology
def: "An anionic group that contains carbon." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic anionic groups" RELATED [chebi]
synonym: "organic anionic groups" RELATED [ChEBI]
is_a: CHEBI:64767 ! anionic group
relationship: is_conjugate_base_of CHEBI:33247 ! organic group
relationship: RO:0018033 CHEBI:33247 ! organic group

[Term]
id: CHEBI:64898
name: anionic amino-acid residue
namespace: chebi_ontology
def: "An amino-acid residue carrying an overall negative charge." []
subset: 3:STAR
subset: 3_STAR
synonym: "amino acid anion residue" RELATED [ChEBI]
synonym: "amino acid anion residue" RELATED [chebi]
synonym: "amino acid anion residues" RELATED [chebi]
synonym: "amino acid anion residues" RELATED [ChEBI]
synonym: "amino-acid anion residue" RELATED [chebi]
synonym: "amino-acid anion residue" RELATED [ChEBI]
synonym: "amino-acid anion residues" RELATED [ChEBI]
synonym: "amino-acid anion residues" RELATED [chebi]
synonym: "anionic amino acid residue" RELATED [chebi]
synonym: "anionic amino acid residue" RELATED [ChEBI]
synonym: "anionic amino acid residues" RELATED [ChEBI]
synonym: "anionic amino acid residues" RELATED [chebi]
is_a: CHEBI:64775 ! organic anionic group
relationship: is_conjugate_base_of CHEBI:33708 ! amino-acid residue
relationship: RO:0018033 CHEBI:33708 ! amino-acid residue

[Term]
id: CHEBI:64909
name: poison
namespace: chebi_ontology
def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." []
subset: 3:STAR
subset: 3_STAR
synonym: "poisonous agent" RELATED [chebi]
synonym: "poisonous agent" RELATED [ChEBI]
synonym: "poisonous agents" RELATED [chebi]
synonym: "poisonous agents" RELATED [ChEBI]
synonym: "poisonous substance" RELATED [chebi]
synonym: "poisonous substance" RELATED [ChEBI]
synonym: "poisonous substances" RELATED [chebi]
synonym: "poisonous substances" RELATED [ChEBI]
synonym: "poisons" RELATED [chebi]
synonym: "poisons" RELATED [ChEBI]
synonym: "toxic agent" RELATED [ChEBI]
synonym: "toxic agent" RELATED [chebi]
synonym: "toxic agents" RELATED [ChEBI]
synonym: "toxic agents" RELATED [chebi]
synonym: "toxic substance" RELATED [ChEBI]
synonym: "toxic substance" RELATED [chebi]
synonym: "toxic substances" RELATED [ChEBI]
synonym: "toxic substances" RELATED [chebi]
xref: Wikipedia:Poison
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:64911
name: antimitotic
namespace: chebi_ontology
def: "Any compound that inhibits cell division (mitosis)." []
subset: 3:STAR
synonym: "antimitotics" RELATED [chebi]
synonym: "mitosis inhibitor" RELATED [chebi]
synonym: "mitosis inhibitors" RELATED [chebi]
synonym: "mitotic inhibitor" RELATED [chebi]
synonym: "mitotic inhibitors" RELATED [chebi]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:64912
name: antimycobacterial drug
namespace: chebi_ontology
def: "A drug used to treat or prevent infections caused by <em>Mycobacteria</em>, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy." []
subset: 3:STAR
synonym: "antimycobacterial agent" RELATED [chebi]
synonym: "antimycobacterial agents" RELATED [chebi]
synonym: "antimycobacterial drugs" RELATED [chebi]
synonym: "antimycobacterials" RELATED [chebi]
synonym: "antimycobacterium" RELATED [chebi]
is_a: CHEBI:36047 ! antibacterial drug

[Term]
id: CHEBI:64915
name: antiplasmodial drug
namespace: chebi_ontology
def: "An antiparasitic drug which is effective against Apicomplexan parasites in the genus <em>Plasmodium</em>. The genus contains over 200 species and includes those responsible for malaria." []
subset: 3:STAR
synonym: "antiplasmodial agent" RELATED [chebi]
synonym: "antiplasmodial agents" RELATED [chebi]
synonym: "antiplasmodial drugs" RELATED [chebi]
synonym: "antiplasmodium agent" RELATED [chebi]
synonym: "antiplasmodium agents" RELATED [chebi]
synonym: "antiplasmodium drug" RELATED [chebi]
synonym: "antiplasmodium drugs" RELATED [chebi]
is_a: CHEBI:35820 ! antiprotozoal drug

[Term]
id: CHEBI:64933
name: melanin synthesis inhibitor
namespace: chebi_ontology
def: "A depigmentation agent which inhibits the synthesis of melanin." []
subset: 3:STAR
synonym: "melanin biosynthesis inhibitor" RELATED [chebi]
synonym: "melanin biosynthesis inhibitors" RELATED [chebi]
synonym: "melanin synthesis inhibitors" RELATED [chebi]
synonym: "melanogenesis inhibitor" RELATED [chebi]
synonym: "melanogenesis inhibitors" RELATED [chebi]
is_a: CHEBI:59864 ! depigmentation drug

[Term]
id: CHEBI:64946
name: anti-HIV agent
namespace: chebi_ontology
def: "An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus." []
subset: 3:STAR
synonym: "anti-AIDS agent" RELATED [chebi]
synonym: "anti-AIDS agents" RELATED [chebi]
synonym: "anti-HIV agents" RELATED [chebi]
is_a: CHEBI:22587 ! antiviral agent

[Term]
id: CHEBI:64996
name: EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor
namespace: chebi_ontology
def: "A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33)." []
subset: 3:STAR
synonym: "15-lipoxygenase inhibitor" RELATED [chebi]
synonym: "15-lipoxygenase inhibitors" RELATED [chebi]
synonym: "15-LOX inhibitor" RELATED [chebi]
synonym: "15-LOX inhibitors" RELATED [chebi]
synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor" RELATED [chebi]
synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitors" RELATED [chebi]
synonym: "arachidonate 15-lipoxygenase inhibitor" RELATED [chebi]
synonym: "arachidonate 15-lipoxygenase inhibitors" RELATED [chebi]
synonym: "arachidonate:oxygen 15-oxidoreductase inhibitor" RELATED [chebi]
synonym: "arachidonate:oxygen 15-oxidoreductase inhibitors" RELATED [chebi]
synonym: "EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitors" RELATED [chebi]
synonym: "EC 1.13.11.33 inhibitor" RELATED [chebi]
synonym: "EC 1.13.11.33 inhibitors" RELATED [chebi]
synonym: "linoleic acid omega(6)-lipoxygenase inhibitor" RELATED [chebi]
synonym: "linoleic acid omega(6)-lipoxygenase inhibitors" RELATED [chebi]
synonym: "omega(6) lipoxygenase inhibitor" RELATED [chebi]
synonym: "omega(6) lipoxygenase inhibitors" RELATED [chebi]
is_a: CHEBI:35856 ! lipoxygenase inhibitor

[Term]
id: CHEBI:65001
name: EC 3.1.1.3 (triacylglycerol lipase) inhibitor
namespace: chebi_ontology
def: "Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3)." []
subset: 3:STAR
synonym: "butyrinase inhibitor" RELATED [chebi]
synonym: "butyrinase inhibitors" RELATED [chebi]
synonym: "cacordase inhibitor" RELATED [chebi]
synonym: "cacordase inhibitors" RELATED [chebi]
synonym: "capalase L inhibitor" RELATED [chebi]
synonym: "capalase L inhibitors" RELATED [chebi]
synonym: "EC 3.1.1.3 (triacylglycerol lipase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.1.3 inhibitor" RELATED [chebi]
synonym: "EC 3.1.1.3 inhibitors" RELATED [chebi]
synonym: "GEH inhibitor" RELATED [chebi]
synonym: "GEH inhibitors" RELATED [chebi]
synonym: "glycerol ester hydrolase inhibitor" RELATED [chebi]
synonym: "glycerol ester hydrolase inhibitors" RELATED [chebi]
synonym: "glycerol-ester hydrolase inhibitor" RELATED [chebi]
synonym: "glycerol-ester hydrolase inhibitors" RELATED [chebi]
synonym: "heparin releasable hepatic lipase inhibitor" RELATED [chebi]
synonym: "heparin releasable hepatic lipase inhibitors" RELATED [chebi]
synonym: "hepatic lipase inhibitor" RELATED [chebi]
synonym: "hepatic lipase inhibitors" RELATED [chebi]
synonym: "hepatic monoacylglycerol acyltransferase inhibitor" RELATED [chebi]
synonym: "hepatic monoacylglycerol acyltransferase inhibitors" RELATED [chebi]
synonym: "lipase inhibitor" RELATED [chebi]
synonym: "lipase inhibitors" RELATED [chebi]
synonym: "lipazin inhibitor" RELATED [chebi]
synonym: "lipazin inhibitors" RELATED [chebi]
synonym: "liver lipase inhibitor" RELATED [chebi]
synonym: "liver lipase inhibitors" RELATED [chebi]
synonym: "pancreatic lipase inhibitor" RELATED [chebi]
synonym: "pancreatic lipase inhibitors" RELATED [chebi]
synonym: "pancreatic triacylglycerol lipase inhibitor" RELATED [chebi]
synonym: "pancreatic triacylglycerol lipase inhibitors" RELATED [chebi]
synonym: "post-heparin plasma protamine-resistant lipase inhibitor" RELATED [chebi]
synonym: "post-heparin plasma protamine-resistant lipase inhibitors" RELATED [chebi]
synonym: "PPL inhibitor" RELATED [chebi]
synonym: "PPL inhibitors" RELATED [chebi]
synonym: "salt-resistant post-heparin lipase inhibitor" RELATED [chebi]
synonym: "salt-resistant post-heparin lipase inhibitors" RELATED [chebi]
synonym: "steapsin inhibitor" RELATED [chebi]
synonym: "steapsin inhibitors" RELATED [chebi]
synonym: "triacetinase inhibitor" RELATED [chebi]
synonym: "triacetinase inhibitors" RELATED [chebi]
synonym: "triacylglycerol ester hydrolase inhibitor" RELATED [chebi]
synonym: "triacylglycerol ester hydrolase inhibitors" RELATED [chebi]
synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitor" RELATED [chebi]
synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitors" RELATED [chebi]
synonym: "triacylglycerol lipase inhibitor" RELATED [chebi]
synonym: "triacylglycerol lipase inhibitors" RELATED [chebi]
synonym: "tributyrase inhibitor" RELATED [chebi]
synonym: "tributyrase inhibitors" RELATED [chebi]
synonym: "tributyrin esterase inhibitor" RELATED [chebi]
synonym: "tributyrin esterase inhibitors" RELATED [chebi]
synonym: "tributyrinase inhibitor" RELATED [chebi]
synonym: "tributyrinase inhibitors" RELATED [chebi]
synonym: "triglyceridase inhibitor" RELATED [chebi]
synonym: "triglyceridase inhibitors" RELATED [chebi]
synonym: "triglyceride hydrolase inhibitor" RELATED [chebi]
synonym: "triglyceride hydrolase inhibitors" RELATED [chebi]
synonym: "triglyceride lipase inhibitor" RELATED [chebi]
synonym: "triglyceride lipase inhibitors" RELATED [chebi]
synonym: "triolein hydrolase inhibitor" RELATED [chebi]
synonym: "triolein hydrolase inhibitors" RELATED [chebi]
synonym: "Tween hydrolase inhibitor" RELATED [chebi]
synonym: "Tween hydrolase inhibitors" RELATED [chebi]
synonym: "tween-hydrolysing esterase inhibitor" RELATED [chebi]
synonym: "tween-hydrolyzing esterase inhibitors" RELATED [chebi]
synonym: "Tweenase inhibitor" RELATED [chebi]
synonym: "Tweenase inhibitors" RELATED [chebi]
synonym: "Tweenesterase inhibitor" RELATED [chebi]
synonym: "Tweenesterase inhibitors" RELATED [chebi]
is_a: CHEBI:76773 ! EC 3.1.1.* (carboxylic ester hydrolase) inhibitor

[Term]
id: CHEBI:65023
name: anti-asthmatic agent
namespace: chebi_ontology
def: "Any compound that has anti-asthmatic effects." []
subset: 3:STAR
synonym: "anti-asthmatic agents" RELATED [chebi]
synonym: "antiasthmatic agent" RELATED [chebi]
synonym: "antiasthmatic agents" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:65076
name: neamine(4+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the four free amino groups of neamine; major species at pH 7.3." []
subset: 3:STAR
synonym: "neamine" RELATED [uniprot_ft]
synonym: "neaminium tetracation" RELATED [chebi]
synonym: "neaminium(4+)" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:7489 ! neamine

[Term]
id: CHEBI:65077
name: neomycin C(6+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the six free amino groups of neomycin C; major species at pH 7.3." []
subset: 3:STAR
synonym: "neomycin C" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:53634 ! neomycin C

[Term]
id: CHEBI:65212
name: polysaccharide derivative
namespace: chebi_ontology
def: "A carbohydrate derivative that is any derivative of a polysaccharide." []
subset: 3:STAR
synonym: "polysaccharide derivatives" RELATED [chebi]
is_a: CHEBI:167559 ! glycan
is_a: CHEBI:33694 ! biomacromolecule
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: RO:0018038 CHEBI:18154 ! polysaccharide

[Term]
id: CHEBI:65255
name: food preservative
namespace: chebi_ontology
def: "Substances which are added to food in order to prevent decomposition caused by  microbial growth or by undesirable chemical changes." []
subset: 3:STAR
synonym: "food preservatives" RELATED [chebi]
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:65256
name: antimicrobial food preservative
namespace: chebi_ontology
def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." []
subset: 3:STAR
synonym: "antimicrobial food preservatives" RELATED [chebi]
synonym: "antimicrobial preservative" RELATED [chebi]
synonym: "antimicrobial preservatives" RELATED [chebi]
is_a: CHEBI:33281 ! antimicrobial agent
is_a: CHEBI:65255 ! food preservative

[Term]
id: CHEBI:65259
name: GABA antagonist
namespace: chebi_ontology
def: "A compound that inhibits the action of γ-aminobutyric acid." []
subset: 3:STAR
synonym: "GABA antagonists" RELATED [chebi]
synonym: "gamma-aminobutyric acid receptor antagonist" RELATED [chebi]
synonym: "gamma-aminobutyric acid receptor antagonists" RELATED [chebi]
is_a: CHEBI:48706 ! antagonist
is_a: CHEBI:51374 ! GABA agent

[Term]
id: CHEBI:65296
name: primary ammonium ion
namespace: chebi_ontology
def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." []
subset: 3:STAR
synonym: "a primary amine" RELATED [uniprot_ft]
synonym: "substituted ammonium" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:50994 ! primary amino compound

[Term]
id: CHEBI:67079
name: anti-inflammatory agent
namespace: chebi_ontology
def: "Any compound that has anti-inflammatory effects." []
subset: 3:STAR
synonym: "anti-inflammatory agents" RELATED [chebi]
synonym: "antiinflammatory agent" RELATED [chebi]
synonym: "antiinflammatory agents" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:6827
name: methicillin
namespace: chebi_ontology
def: "A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "6beta-(2,6-dimethoxybenzamido)penicillanic acid" RELATED [chebi]
synonym: "Methicillin" RELATED [kegg.compound]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:52064 ! methicillin(1-)

[Term]
id: CHEBI:68452
name: azole
namespace: chebi_ontology
def: "Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen." []
subset: 3:STAR
synonym: "azoles" RELATED [chebi]
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38179 ! monocyclic heteroarene

[Term]
id: CHEBI:68481
name: mTOR inhibitor
namespace: chebi_ontology
def: "A protein kinase inhibitor of the <em>m</em>ammalian <em>t</em>arget <em>o</em>f <em>r</em>apamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer." []
subset: 3:STAR
synonym: "mammalian target of rapamycin inhibitor" RELATED [chebi]
synonym: "mammalian target of rapamycin inhibitors" RELATED [chebi]
synonym: "mTOR inhibitors" RELATED [chebi]
is_a: CHEBI:37699 ! protein kinase inhibitor

[Term]
id: CHEBI:68495
name: apoptosis inducer
namespace: chebi_ontology
def: "Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms." []
subset: 3:STAR
synonym: "apoptosis inducers" RELATED [chebi]
synonym: "Type I cell-death inducer" RELATED [chebi]
synonym: "Type I cell-death inducers" RELATED [chebi]
synonym: "Type I programmed cell-death inducer" RELATED [chebi]
synonym: "Type I programmed cell-death inducers" RELATED [chebi]
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:69136
name: latrunculin A
namespace: chebi_ontology
alt_id: CHEBI:43626
def: "A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge <em>Latrunculia magnifica</em> and from the Fiji Islands sponge <em>Cacospongia mycofijiensis</em>. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes." []
subset: 3:STAR
synonym: "(+)-latrunculin A" RELATED [chebi]
synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" EXACT [PDBeChem]
synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" RELATED [pdb-ccd]
synonym: "LAT-A" RELATED [chemidplus]
synonym: "LatA" RELATED [chebi]
synonym: "LATRUNCULIN A" RELATED [pdb-ccd]
synonym: "NSC 613011" RELATED [chemidplus]
is_a: CHEBI:25106 ! macrolide
is_a: CHEBI:46733 ! oxabicycloalkane
is_a: CHEBI:48891 ! thiazolidinone
is_a: CHEBI:59780 ! cyclic hemiketal
relationship: RO:0000087 CHEBI:27026 ! has role toxin
relationship: RO:0000087 CHEBI:70728 ! has role actin polymerisation inhibitor

[Term]
id: CHEBI:6923
name: miconazole
namespace: chebi_ontology
alt_id: CHEBI:108917
def: "A racemate composed of equimolar amounts of (<i>R</i>)- and (<i>S</i>)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes." []
subset: 3:STAR
synonym: "(+-)-miconazole" RELATED [chebi]
synonym: "(RS)-miconazole" RELATED [chebi]
synonym: "1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole" RELATED [chemidplus]
synonym: "1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole" RELATED [chembl]
synonym: "Daktarin IV" RELATED [chemidplus]
synonym: "Miconazole" RELATED [kegg.drug]
synonym: "Monistat IV (TN)" RELATED [kegg.drug]
synonym: "rac-miconazole" RELATED [chebi]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87069 ! imidazole antifungal drug
is_a: CHEBI:87071 ! conazole antifungal drug
relationship: BFO:0000051 CHEBI:82894 ! has part (R)-miconazole
relationship: BFO:0000051 CHEBI:82897 ! has part (S)-miconazole
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:82891 ! has role glucocorticoid receptor antagonist

[Term]
id: CHEBI:7025
name: mupirocin
namespace: chebi_ontology
alt_id: CHEBI:44038
def: "An α,β-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2<i>E</i>)-4-[(2<i>S</i>)-tetrahydro-2<em>H</em>-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2<i>S</i>,3<i>S</i>)-3-[(2<i>S</i>,3<i>S</i>)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium <em>Pseudomonas fluorescens</em>, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections." []
subset: 3:STAR
synonym: "Pseudomonic acid A" RELATED [chemidplus]
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:27136 ! triol
is_a: CHEBI:32955 ! epoxide
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:46942 ! oxanes
is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018034 CHEBI:145790 ! mupirocin(1-)

[Term]
id: CHEBI:70727
name: topoisomerase inhibitor
namespace: chebi_ontology
def: "An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA)." []
subset: 3:STAR
synonym: "topoisomerase inhibitors" RELATED [chebi]
is_a: CHEBI:76830 ! EC 5.99.1.* (miscellaneous isomerase) inhibitor

[Term]
id: CHEBI:70728
name: actin polymerisation inhibitor
namespace: chebi_ontology
def: "Any substance that inhibits the polymerisation of the protein actin." []
subset: 3:STAR
synonym: "actin polymerisation inhibitors" RELATED [chebi]
synonym: "actin polymerization inhibitor" RELATED [chebi]
synonym: "actin polymerization inhibitors" RELATED [chebi]
synonym: "inhibitor of actin polymerization" RELATED [chebi]
synonym: "inhibitors of actin polymerization" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor

[Term]
id: CHEBI:70977
name: alkane-alpha,omega-diammonium(2+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the amino groups of any alkane-α,ω-diamine; major species at pH 7.3." []
subset: 3:STAR
synonym: "an alkane-alpha,omega-diamine" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:35411 ! alkane-alpha,omega-diamine

[Term]
id: CHEBI:71181
name: Sir2 inhibitor
namespace: chebi_ontology
def: "An EC 3.5.1.98 (histone deacetylase) inhibitor that interferes with the action of Sir2." []
subset: 3:STAR
synonym: "Sir2 inhibitors" RELATED [chebi]
is_a: CHEBI:61115 ! EC 3.5.1.98 (histone deacetylase) inhibitor

[Term]
id: CHEBI:71285
name: organophosphonate(2-)
namespace: chebi_ontology
def: "An organophosphonate oxoanion obtained by deprotonation of both phosphonate OH groups of any phosphonic acid." []
subset: 3:STAR
synonym: "organophosphonate" RELATED [chebi]
synonym: "organophosphonate dianion" RELATED [chebi]
is_a: CHEBI:59635 ! organophosphonate oxoanion

[Term]
id: CHEBI:71300
name: EC 2.* (transferase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)" []
subset: 3:STAR
synonym: "EC 2 inhibitor" RELATED [chebi]
synonym: "EC 2 inhibitors" RELATED [chebi]
synonym: "EC 2.* (transferase) inhibitors" RELATED [chebi]
synonym: "EC 2.* inhibitor" RELATED [chebi]
synonym: "EC 2.* inhibitors" RELATED [chebi]
synonym: "transferase inhibitor" RELATED [chebi]
synonym: "transferase inhibitors" RELATED [chebi]
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:71321
name: fusidate
namespace: chebi_ontology
def: "A steroid acid anion that is the conjugate base of fusidic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3." []
subset: 3:STAR
synonym: "fusidate" RELATED [uniprot_ft]
synonym: "fusidine" RELATED [metacyc.compound]
synonym: "ramycin" RELATED [metacyc.compound]
is_a: CHEBI:50160 ! steroid acid anion
relationship: RO:0018033 CHEBI:29013 ! fusidic acid

[Term]
id: CHEBI:71337
name: minocycline(1-)
namespace: chebi_ontology
def: "An organic anion that is the conjugate base of minocycline, obtained by deprotonation of the two enolic hydroxy groups and protonation of the non-aromatic tertiary amino group." []
subset: 3:STAR
synonym: "minocycline anion" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0018033 CHEBI:50694 ! minocycline
relationship: RO:0018033 CHEBI:77906 ! minocycline zwitterion

[Term]
id: CHEBI:71339
name: novobiocin(1-)
namespace: chebi_ontology
def: "An organic anion that is the conjugate base of novobiocin." []
subset: 3:STAR
synonym: "novobiocin" RELATED [uniprot_ft]
synonym: "novobiocin anion" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0018033 CHEBI:28368 ! novobiocin

[Term]
id: CHEBI:71365
name: rifampicin zwitterion
namespace: chebi_ontology
def: "A zwitterion obtained by transfer of a proton from the 5-hydroxy group to the tertiary amino group of rifampicin; major species at pH 7.3." []
subset: 3:STAR
synonym: "rifampicin" RELATED [uniprot_ft]
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:28077 ! rifampicin

[Term]
id: CHEBI:71392
name: tetracycline(1-)
namespace: chebi_ontology
def: "An organic anion that is the conjugate base of tetracycline zwitterion obtained by deprotonation of the two enolic hydroxy groups and protonation of the tertiary amino group." []
subset: 3:STAR
synonym: "tetracycline anion" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
relationship: RO:0018033 CHEBI:77932 ! tetracycline zwitterion

[Term]
id: CHEBI:71415
name: nitrofurantoin
namespace: chebi_ontology
alt_id: CHEBI:7591
def: "An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA." []
subset: 3:STAR
synonym: "1-((5-Nitrofurfurylidene)amino)hydantoin" RELATED [chemidplus]
synonym: "1-(5-Nitro-2-furfurylidenamino)hydantoin" RELATED [chemidplus]
synonym: "1-(5-Nitro-2-furfurylideneamino)hydantoin" RELATED [chemidplus]
synonym: "1-[(5-Nitrofurfurylidene)amino]hydantoin" RELATED [nist]
synonym: "5-Nitrofurantoin" RELATED [nist]
synonym: "N-(5-Nitrofurfurylidene)-1-aminohydantoin" RELATED [chemidplus]
is_a: CHEBI:24628 ! imidazolidine-2,4-dione
is_a: CHEBI:87230 ! nitrofuran antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent
relationship: RO:0018038 CHEBI:28306 ! semicarbazide

[Term]
id: CHEBI:71543
name: rotenoid
namespace: chebi_ontology
def: "Members of the class of tetrahydrochromenochromene that consists of a <i>cis</i>-fused tetrahydrochromeno[3,4-<em>b</em>]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds." []
subset: 3:STAR
synonym: "rotenoids" RELATED [chebi]
is_a: CHEBI:72544 ! flavonoids
is_a: CHEBI:72579 ! tetrahydrochromenochromene

[Term]
id: CHEBI:71629
name: nisin
namespace: chebi_ontology
def: "A type-A lantibiotic containing 34 amino acid residues (including lanthionine (Lan), methyllanthionine (MeLan), didehydroalanine (Dha) and didehydroaminobutyric acid (Dhb)) and five thioether bridges. It is obtained by fermentation of the bacterium <em>Lactococcus lactis</em> and shows particular activity against <em>Clostridium botulinum</em>. It is used in the production of various processed foods to suppress Gram-positive spoilage and pathogenic bacteria and so extend shelf life." []
subset: 3:STAR
synonym: "E234" RELATED [chebi]
synonym: "EINECS 215-807-5" RELATED [chemidplus]
synonym: "NSC 112903" RELATED [chemidplus]
synonym: "NSC-112903" RELATED [chemidplus]
is_a: CHEBI:51026 ! macrocycle
is_a: CHEBI:71645 ! type A lantibiotic
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:65256 ! has role antimicrobial food preservative

[Term]
id: CHEBI:71644
name: lantibiotic
namespace: chebi_ontology
def: "A class of peptide antibiotic characterised by the presence of the rare thioether amino acids lanthionine or methyllanthionine, as well as the unsaturated amino acids dehydroalanine and 2-aminoisobutyric acid. In contrast to classical peptide antibiotics, lantibiotics are synthesised from precursor genes using the ribosomal pathway and the characteristic rare amino acids are introduced by posttranslational modification procedues into the lantibiotic precursor peptides ('prepeptides'). Lantibiotics are subdivided into two types: type A have long, flexible structures, while type B have rigid, globular structures." []
subset: 3:STAR
synonym: "lantibiotics" RELATED [chebi]
is_a: CHEBI:15841 ! polypeptide
is_a: CHEBI:25903 ! peptide antibiotic

[Term]
id: CHEBI:71645
name: type A lantibiotic
namespace: chebi_ontology
def: "Any lantibiotic which has which has a long, flexible structure." []
subset: 3:STAR
synonym: "type 1 lantibiotic" RELATED [chebi]
synonym: "type 1 lantibiotics" RELATED [chebi]
synonym: "type A lantibiotics" RELATED [chebi]
synonym: "type-A lantibiotic" RELATED [chebi]
synonym: "type-A lantibiotics" RELATED [chebi]
is_a: CHEBI:71644 ! lantibiotic

[Term]
id: CHEBI:71989
name: ortho ester
namespace: chebi_ontology
def: "Any organooxygen compound that has the general formula RC(OR<small><sup>1</small></sup>)(OR<small><sup>2</small></sup>)(OR<small><sup>3</small></sup>), where R<small><sup>1</small></sup>, R<small><sup>2</small></sup>, R<small><sup>3</small></sup> ≠ H." []
subset: 3:STAR
synonym: "ortho esters" RELATED [chebi]
synonym: "ortho-ester" RELATED [chebi]
synonym: "ortho-esters" RELATED [chebi]
synonym: "orthoester" RELATED [chebi]
synonym: "orthoesters" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:72316
name: virulence factor
namespace: chebi_ontology
def: "Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host." []
subset: 3:STAR
synonym: "virulence factors" RELATED [chebi]
is_a: CHEBI:27026 ! toxin

[Term]
id: CHEBI:72544
name: flavonoids
namespace: chebi_ontology
def: "Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C<small><sub>15</sub></small> or C<small><sub>16</sub></small> skeleton, or such a structure which is condensed with a C<small><sub>6</sub></small>-C<small><sub>3</sub></small> lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them." []
subset: 3:STAR
synonym: "flavonoid" RELATED [chebi]
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72579
name: tetrahydrochromenochromene
namespace: chebi_ontology
def: "Any chromenochromene resulting from the formal <i>cis</i>-fusion of two dihydro chromene rings, together with their substituted derivatives." []
subset: 3:STAR
synonym: "tetrahydrochromenochromenes" RELATED [chebi]
is_a: CHEBI:133135 ! chromenochromene

[Term]
id: CHEBI:72581
name: rotenones
namespace: chebi_ontology
def: "Members of the class of rotenoid which consists of a 6a,12a-dihydrochromeno[3,4-<em>b</em>]chromen-12(6<em>H</em>)-one skeleton and its substituted products." []
subset: 3:STAR
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:71543 ! rotenoid

[Term]
id: CHEBI:72588
name: semisynthetic derivative
namespace: chebi_ontology
def: "Any organic molecular entity derived from a natural product by partial chemical synthesis." []
subset: 3:STAR
synonym: "semi-synthetic compound" RELATED [chebi]
synonym: "semi-synthetic compounds" RELATED [chebi]
synonym: "semi-synthetic derivative" RELATED [chebi]
synonym: "semi-synthetic derivatives" RELATED [chebi]
synonym: "semisynthetic compound" RELATED [chebi]
synonym: "semisynthetic compounds" RELATED [chebi]
synonym: "semisynthetic derivatives" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72600
name: spiroketal
namespace: chebi_ontology
def: "A cyclic ketal in which the ketal carbon is the only common atom of two rings." []
subset: 3:STAR
synonym: "spiroacetal" RELATED [chebi]
synonym: "spiroacetals" RELATED [chebi]
synonym: "spiroketals" RELATED [chebi]
is_a: CHEBI:37948 ! oxaspiro compound
is_a: CHEBI:59779 ! cyclic ketal

[Term]
id: CHEBI:72695
name: organic molecule
namespace: chebi_ontology
def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." []
subset: 3:STAR
subset: 3_STAR
synonym: "organic compound" RELATED [ChEBI]
synonym: "organic compound" RELATED [chebi]
synonym: "organic compounds" RELATED [chebi]
synonym: "organic compounds" RELATED [ChEBI]
synonym: "organic molecules" RELATED [ChEBI]
synonym: "organic molecules" RELATED [chebi]
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72768
name: aryl hydrocarbon receptor agonist
namespace: chebi_ontology
def: "An agonist that binds to and activates aryl hydrocarbon receptors (AhRs)." []
subset: 3:STAR
synonym: "AHR agonist" RELATED [chebi]
synonym: "AhR agonist" RELATED [chebi]
synonym: "AHR agonists" RELATED [chebi]
synonym: "AhR agonists" RELATED [chebi]
synonym: "aryl hydrocarbon receptor agonists" RELATED [chebi]
is_a: CHEBI:48705 ! agonist

[Term]
id: CHEBI:73080
name: hemiaminal
namespace: chebi_ontology
def: "Any organic amino compound that has an amino group and a hydroxy group attached to the same carbon atom. Hemiaminals are intermediates in the formation of imines by addition of an amine to an aldehyde or ketone; those derived from primary amines are particularly unstable." []
subset: 3:STAR
synonym: "carbinolamine" RELATED [chebi]
synonym: "carbinolamines" RELATED [chebi]
synonym: "hemiaminals" RELATED [chebi]
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:73181
name: EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor
namespace: chebi_ontology
def: "An  EC 1.11.1.* (peroxidases) inhibitor that inhibits the action of <small>L</small>-ascorbate peroxidase (EC 1.11.1.11)." []
subset: 3:STAR
synonym: "ascorbate peroxidase inhibitor" RELATED [chebi]
synonym: "ascorbate peroxidase inhibitors" RELATED [chebi]
synonym: "ascorbic acid peroxidase inhibitor" RELATED [chebi]
synonym: "ascorbic acid peroxidase inhibitors" RELATED [chebi]
synonym: "EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors" RELATED [chebi]
synonym: "EC 1.11.1.11 inhibitor" RELATED [chebi]
synonym: "EC 1.11.1.11 inhibitors" RELATED [chebi]
synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitor" RELATED [chebi]
synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitors" RELATED [chebi]
synonym: "L-ascorbate peroxidase inhibitor" RELATED [chebi]
synonym: "L-ascorbate peroxidase inhibitors" RELATED [chebi]
synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitor" RELATED [chebi]
synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors" RELATED [chebi]
synonym: "L-ascorbic acid peroxidase inhibitor" RELATED [chebi]
synonym: "L-ascorbic acid peroxidase inhibitors" RELATED [chebi]
synonym: "L-ascorbic acid-specific peroxidase inhibitor" RELATED [chebi]
synonym: "L-ascorbic acid-specific peroxidase inhibitors" RELATED [chebi]
is_a: CHEBI:75381 ! EC 1.11.1.* (peroxidases) inhibitor

[Term]
id: CHEBI:73216
name: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:76765
def: "Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*)." []
subset: 3:STAR
synonym: "acid anhydride hydrolase inhibitor" RELATED [chebi]
synonym: "acid anhydride hydrolase inhibitors" RELATED [chebi]
synonym: "EC 3.6 inhibitor" RELATED [chebi]
synonym: "EC 3.6 inhibitors" RELATED [chebi]
synonym: "EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors" RELATED [chebi]
synonym: "EC 3.6.* inhibitor" RELATED [chebi]
synonym: "EC 3.6.* inhibitors" RELATED [chebi]
synonym: "EC 3.6.*.* inhibitor" RELATED [chebi]
synonym: "EC 3.6.*.* inhibitors" RELATED [chebi]
synonym: "inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [chebi]
synonym: "inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [chebi]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:73336
name: vulnerary
namespace: chebi_ontology
def: "A drug used in treating and healing of wounds." []
subset: 3:STAR
synonym: "vulneraries" RELATED [chebi]
synonym: "wound-healing agent" RELATED [chebi]
synonym: "wound-healing agents" RELATED [chebi]
synonym: "wound-healing drug" RELATED [chebi]
synonym: "wound-healing drugs" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:73474
name: acetylenic compound
namespace: chebi_ontology
def: "Any organic molecule containing a C≡C bond." []
subset: 3:STAR
synonym: "acetylenic compounds" RELATED [chebi]
synonym: "C#C containing compound" RELATED [chebi]
synonym: "C#C containing compounds" RELATED [chebi]
synonym: "C#C-containing compound" RELATED [chebi]
synonym: "C#C-containing compounds" RELATED [chebi]
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:73537
name: 1,8-naphthyridine derivative
namespace: chebi_ontology
def: "Any naphthyridine derivative that is a derivative of 1,8-naphthyridine." []
subset: 3:STAR
synonym: "1,8-naphthyridine derivatives" RELATED [chebi]
is_a: CHEBI:73539 ! naphthyridine derivative
relationship: RO:0018040 CHEBI:36628 ! 1,8-naphthyridine

[Term]
id: CHEBI:73539
name: naphthyridine derivative
namespace: chebi_ontology
def: "Any organonitrogen heterocyclic compound that is a derivative of a naphthyridine." []
subset: 3:STAR
synonym: "naphthyridine derivatives" RELATED [chebi]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
relationship: RO:0018040 CHEBI:36624 ! naphthyridine

[Term]
id: CHEBI:73678
name: tobramycin(5+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the five amino groups of tobramycin." []
subset: 3:STAR
synonym: "tobramycin" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:28864 ! tobramycin

[Term]
id: CHEBI:73754
name: thiosugar
namespace: chebi_ontology
def: "A carbohydrate derivative in which one or more of the oxygens or hydroxy groups of the parent carbohydrate is replaced by sulfur or -SR, where R can be hydrogen or any group." []
subset: 3:STAR
synonym: "thiosugars" RELATED [chebi]
is_a: CHEBI:33261 ! organosulfur compound
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:73913
name: antifolate
namespace: chebi_ontology
def: "An antimetabolite that impairs the action of folic acids" []
subset: 3:STAR
synonym: "antifolates" RELATED [chebi]
synonym: "folic acid antagonist" RELATED [chebi]
synonym: "folic acid antagonists" RELATED [chebi]
is_a: CHEBI:35221 ! antimetabolite

[Term]
id: CHEBI:74159
name: D-cycloserine zwitterion
namespace: chebi_ontology
def: "A zwitterion resulting from the transfer of a proton from the ring nitrogen to the primary amino group of <small>D</small>-cycloserine. The major species at pH 7.3." []
subset: 3:STAR
synonym: "(+)-4-amino-3-isoxazolidinone zwitterion" RELATED [chebi]
synonym: "(4R)-4-aminoisoxazolidin-3-one zwitterion" RELATED [chebi]
synonym: "alpha-cycloserine zwitterion" RELATED [chebi]
synonym: "cycloserine zwitterion" RELATED [chebi]
synonym: "D-4-amino-3-isoxazolidinone zwitterion" RELATED [chebi]
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018036 CHEBI:40009 ! D-cycloserine

[Term]
id: CHEBI:7451
name: naftifine
namespace: chebi_ontology
def: "A tertiary amine in which the nitrogen is substituted by methyl, α-naphthylmethyl, and (1<i>E</i>)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections." []
subset: 3:STAR
synonym: "(E)-N-cinnamyl-N-methyl-1-naphthalenemethylamine" RELATED [chemidplus]
synonym: "naftifin" RELATED [chemidplus]
synonym: "trans-N-cinnamyl-N-methyl-(1-naphthylmethyl)amine" RELATED [chebi]
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:32876 ! tertiary amine
is_a: CHEBI:87127 ! allylamine antifungal drug
relationship: RO:0000087 CHEBI:59285 ! has role EC 1.14.13.132 (squalene monooxygenase) inhibitor
relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor

[Term]
id: CHEBI:747204
name: reference compound
namespace: chebi_ontology
def: "Any well-characterized compound that serves as a standard for the identification, quantification, calibration, or quality control of substances in scientific analysis." []
subset: 3:STAR
synonym: "reference compounds" RELATED [chebi]
synonym: "reference standard" RELATED [chebi]
synonym: "reference standards" RELATED [chebi]
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:747325
name: additive
namespace: chebi_ontology
def: "a role for a chemical additive to a mixture" []
subset: 2:STAR
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:74783
name: astringent
namespace: chebi_ontology
def: "A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions." []
subset: 3:STAR
synonym: "adstringent" RELATED [chebi]
synonym: "adstringents" RELATED [chebi]
synonym: "astringents" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:74818
name: heteroaryl hydroxy compound
namespace: chebi_ontology
def: "Any organic aromatic compound having one or more hydroxy groups attached to a heteroarene ring." []
subset: 3:STAR
synonym: "hetaryl hydroxy compound" RELATED [chebi]
synonym: "hetaryl hydroxy compounds" RELATED [chebi]
synonym: "heteroaromatic hydroxy compound" RELATED [chebi]
synonym: "heteroaromatic hydroxy compounds" RELATED [chebi]
synonym: "heteroaryl hydroxy compounds" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:7489
name: neamine
namespace: chebi_ontology
alt_id: CHEBI:46591
alt_id: CHEBI:481318
def: "2-Deoxy-<small>D</small>-streptamine glycosylated at the 4-oxygen with a 6-amino-α-<small>D</small>-glucosaminyl group." []
subset: 3:STAR
synonym: "2-desoxy-4-O-(2,6-diamino-2,6-didesoxy-alpha-D-glucopyranosyl)-D-streptamin" RELATED [chemidplus]
synonym: "4-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine" RELATED [chemidplus]
synonym: "Neamine" RELATED [kegg.compound]
synonym: "neamine" RELATED [chembl]
synonym: "Neomycin A" RELATED [kegg.compound]
is_a: CHEBI:47779 ! aminoglycoside
is_a: CHEBI:53628 ! 2,6-dideoxy-alpha-D-glucoside
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0018033 CHEBI:65076 ! neamine(4+)

[Term]
id: CHEBI:7507
name: neomycin
namespace: chebi_ontology
def: "A broad-spectrum highly toxic antibiotic or mixture of antibiotics produced by a streptomyces (<em>Streptomyces fradiae</em>) and used medically especially to treat local infections." []
subset: 3:STAR
synonym: "Neomycin" RELATED [kegg.compound]
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic
relationship: BFO:0000051 CHEBI:53634 ! has part neomycin C
relationship: BFO:0000051 CHEBI:7489 ! has part neamine
relationship: BFO:0000051 CHEBI:7508 ! has part framycetin

[Term]
id: CHEBI:7508
name: framycetin
namespace: chebi_ontology
alt_id: CHEBI:44577
def: "A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B." []
subset: 3:STAR
synonym: "Fradiomycin B" RELATED [kegg.compound]
synonym: "Framycetin" RELATED [chemidplus, kegg.compound]
synonym: "Neomycin B" RELATED [kegg.compound]
is_a: CHEBI:47779 ! aminoglycoside
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50904 ! has role allergen
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0018033 CHEBI:87835 ! framycetin(6+)

[Term]
id: CHEBI:7528
name: netilmycin
namespace: chebi_ontology
subset: 3:STAR
synonym: "1-N-Ethylsisomicin" RELATED [chemidplus]
synonym: "Netilmicin" RELATED [kegg.compound]
synonym: "O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-N(1)-ethyl-D-streptamine" RELATED [chemidplus]
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic
is_a: CHEBI:28079 ! beta-L-arabinoside
is_a: CHEBI:63367 ! monosaccharide derivative
relationship: RO:0018038 CHEBI:27955 ! streptamine

[Term]
id: CHEBI:75282
name: ergosterol biosynthesis inhibitor
namespace: chebi_ontology
def: "Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol." []
subset: 3:STAR
synonym: "ergosterol biosynthesis inhibitors" RELATED [chebi]
is_a: CHEBI:83317 ! sterol biosynthesis inhibitor

[Term]
id: CHEBI:75283
name: miltefosine
namespace: chebi_ontology
def: "A phospholipid that is the hexadecyl monoester of phosphocholine." []
subset: 3:STAR
synonym: "Hexadecylphosphocholine" RELATED [chemidplus]
synonym: "Hexadecylphosphorylcholine" RELATED [chemidplus]
synonym: "monohexadecylphosphocholine" RELATED [chebi]
synonym: "monohexadecylphosphorylcholine" RELATED [chebi]
is_a: CHEBI:16247 ! phospholipid
is_a: CHEBI:36700 ! phosphocholines
relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug
relationship: RO:0000087 CHEBI:37699 ! has role protein kinase inhibitor
relationship: RO:0000087 CHEBI:50846 ! has role immunomodulator
relationship: RO:0000087 CHEBI:67079 ! has role anti-inflammatory agent
relationship: RO:0000087 CHEBI:68495 ! has role apoptosis inducer

[Term]
id: CHEBI:75381
name: EC 1.11.1.* (peroxidases) inhibitor
namespace: chebi_ontology
def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any of the peroxidases (EC 1.11.1.*)." []
subset: 3:STAR
synonym: "EC 1.11.1 inhibitor" RELATED [chebi]
synonym: "EC 1.11.1 inhibitors" RELATED [chebi]
synonym: "EC 1.11.1.* (peroxidase) inhibitor" RELATED [chebi]
synonym: "EC 1.11.1.* (peroxidase) inhibitors" RELATED [chebi]
synonym: "EC 1.11.1.* (peroxidases) inhibitors" RELATED [chebi]
synonym: "EC 1.11.1.* inhibitor" RELATED [chebi]
synonym: "EC 1.11.1.* inhibitors" RELATED [chebi]
synonym: "inhibitor of peroxidases" RELATED [chebi]
synonym: "inhibitors of peroxidases" RELATED [chebi]
synonym: "peroxidases inhibitors" RELATED [chebi]
is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor

[Term]
id: CHEBI:75592
name: L-cycloserine
namespace: chebi_ontology
def: "A 4-amino-1,2-oxazolidin-3-one that has <i>S</i> configuration. An antibiotic isolated from <em>Erwinia uredovora</em>." []
subset: 3:STAR
synonym: "(-)-4-amino-3-isoxazolidinone" RELATED [chemidplus]
synonym: "(-)-4-aminoisoxazolidin-3-one" RELATED [chebi]
synonym: "(-)-cycloserine" RELATED [chebi]
synonym: "(4S)-4-aminoisoxazolidin-3-one" RELATED [iupac]
synonym: "(S)-(-)-cycloserine" RELATED [chemidplus]
synonym: "(S)-4-amino-3-isoxazolidinone" RELATED [chemidplus]
synonym: "(S)-4-amino-isoxazolidin-3-one" RELATED [chebi]
synonym: "cyclo-L-serine" RELATED [chemidplus]
synonym: "L-4-aminoisoxazolidin-3-one" RELATED [chebi]
synonym: "L-CS" RELATED [chebi]
is_a: CHEBI:23503 ! 4-amino-1,2-oxazolidin-3-one
relationship: RO:0000087 CHEBI:35623 ! has role anticonvulsant
relationship: RO:0000087 CHEBI:59647 ! has role EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
relationship: RO:0000087 CHEBI:64946 ! has role anti-HIV agent
relationship: RO:0018039 CHEBI:40009 ! D-cycloserine

[Term]
id: CHEBI:75596
name: EC 5.* (isomerase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*)." []
subset: 3:STAR
synonym: "EC 5.* (isomerase) inhibitors" RELATED [chebi]
synonym: "EC 5.* inhibitor" RELATED [chebi]
synonym: "EC 5.* inhibitors" RELATED [chebi]
synonym: "EC 5.*.*.* inhibitor" RELATED [chebi]
synonym: "EC 5.*.*.* inhibitors" RELATED [chebi]
synonym: "isomerase (EC 5.*) inhibitor" RELATED [chebi]
synonym: "isomerase (EC 5.*) inhibitors" RELATED [chebi]
synonym: "isomerase inhibitor" RELATED [chebi]
synonym: "isomerase inhibitors" RELATED [chebi]
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:75606
name: hydroxamic acid ester
namespace: chebi_ontology
def: "A carboxamide that is a hydroxamic acid in which the hydrogen of the hydroxy group is replaced by an organyl group." []
subset: 3:STAR
synonym: "hydroxamate ester" RELATED [chebi]
synonym: "hydroxamate esters" RELATED [chebi]
synonym: "hydroxamic acid esters" RELATED [chebi]
synonym: "RC(O)NHOR'" RELATED [chebi]
synonym: "RCONHOR'" RELATED [chebi]
is_a: CHEBI:37622 ! carboxamide
relationship: RO:0018038 CHEBI:24650 ! hydroxamic acid

[Term]
id: CHEBI:75616
name: gentamicin C(5+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the five amino groups of any gentamicin C." []
subset: 3:STAR
synonym: "gentamicin C" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:28417 ! gentamycin C

[Term]
id: CHEBI:7566
name: Nifurtimox
namespace: chebi_ontology
subset: 2:STAR
synonym: "Bayer 2502" RELATED [drugcentral]
synonym: "lampit" RELATED [drugcentral]
synonym: "Nifurtimox" RELATED [kegg.compound]
is_a: CHEBI:87230 ! nitrofuran antibiotic

[Term]
id: CHEBI:75763
name: eukaryotic metabolite
namespace: chebi_ontology
def: "Any  metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." []
subset: 3:STAR
subset: 3_STAR
synonym: "eukaryotic metabolites" RELATED [ChEBI]
synonym: "eukaryotic metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:75767
name: animal metabolite
namespace: chebi_ontology
alt_id: CHEBI:77721
alt_id: CHEBI:77743
def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." []
subset: 3:STAR
subset: 3_STAR
synonym: "animal metabolites" RELATED [chebi]
synonym: "animal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:75768
name: mammalian metabolite
namespace: chebi_ontology
alt_id: CHEBI:77464
alt_id: CHEBI:77744
def: "Any animal metabolite produced during a metabolic reaction in mammals." []
subset: 3:STAR
subset: 3_STAR
synonym: "mammalian metabolites" RELATED [chebi]
synonym: "mammalian metabolites" RELATED [ChEBI]
is_a: CHEBI:75767 ! animal metabolite

[Term]
id: CHEBI:75769
name: B vitamin
namespace: chebi_ontology
def: "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B<small><sub>1</sub></small>, B<small><sub>2</sub></small>, B<small><sub>3</sub></small>, B<small><sub>5</sub></small>, B<small><sub>6</sub></small>, B<small><sub>7</sub></small>, B<small><sub>9</sub></small>, and B<small><sub>12</sub></small> (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." []
subset: 3:STAR
synonym: "B vitamins" RELATED [chebi]
synonym: "B-group vitamin" RELATED [chebi]
synonym: "B-group vitamins" RELATED [chebi]
synonym: "vitamin B" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: RO:0000087 CHEBI:27314 ! has role water-soluble vitamin (role)
relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical

[Term]
id: CHEBI:75771
name: mouse metabolite
namespace: chebi_ontology
def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (<em>Mus musculus</em>)." []
subset: 3:STAR
subset: 3_STAR
synonym: "mouse metabolites" RELATED [ChEBI]
synonym: "mouse metabolites" RELATED [chebi]
synonym: "Mus musculus metabolite" RELATED [ChEBI]
synonym: "Mus musculus metabolite" RELATED [chebi]
synonym: "Mus musculus metabolites" RELATED [ChEBI]
synonym: "Mus musculus metabolites" RELATED [chebi]
is_a: CHEBI:75768 ! mammalian metabolite

[Term]
id: CHEBI:75772
name: Saccharomyces cerevisiae metabolite
namespace: chebi_ontology
alt_id: CHEBI:76949
alt_id: CHEBI:76951
def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (<em>Saccharomyces cerevisiae </em>)." []
subset: 3:STAR
subset: 3_STAR
synonym: "baker's yeast metabolite" RELATED [ChEBI]
synonym: "baker's yeast metabolite" RELATED [chebi]
synonym: "baker's yeast metabolites" RELATED [chebi]
synonym: "baker's yeast metabolites" RELATED [ChEBI]
synonym: "baker's yeast secondary metabolite" RELATED [ChEBI]
synonym: "baker's yeast secondary metabolite" RELATED [chebi]
synonym: "baker's yeast secondary metabolites" RELATED [chebi]
synonym: "baker's yeast secondary metabolites" RELATED [ChEBI]
synonym: "S. cerevisiae metabolite" RELATED [ChEBI]
synonym: "S. cerevisiae metabolite" RELATED [chebi]
synonym: "S. cerevisiae metabolites" RELATED [chebi]
synonym: "S. cerevisiae metabolites" RELATED [ChEBI]
synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI]
synonym: "S. cerevisiae secondary metabolite" RELATED [chebi]
synonym: "S. cerevisiae secondary metabolites" RELATED [chebi]
synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae metabolites" RELATED [chebi]
synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [chebi]
is_a: CHEBI:76946 ! fungal metabolite

[Term]
id: CHEBI:75787
name: prokaryotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." []
subset: 3:STAR
subset: 3_STAR
synonym: "prokaryotic metabolites" RELATED [chebi]
synonym: "prokaryotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:75929
name: D-cycloserine(1+)
namespace: chebi_ontology
def: "An organic cation that is the conjugate acid of <small>D</small>-cycloserine, obtained by protonation of the amino group." []
subset: 3:STAR
synonym: "D-cycloserine" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:40009 ! D-cycloserine

[Term]
id: CHEBI:75954
name: vancomycin aglycone zwitterion
namespace: chebi_ontology
def: "A peptide zwitterion obtained by transfer of a proton from the carboxy to the amino group of vancomycin aglycone." []
subset: 3:STAR
is_a: CHEBI:60466 ! peptide zwitterion
relationship: RO:0018034 CHEBI:77981 ! vancomycin aglycone(1-)
relationship: RO:0018036 CHEBI:47724 ! vancomycin aglycone

[Term]
id: CHEBI:76042
name: aromatic amino-acid zwitterion
namespace: chebi_ontology
def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid." []
subset: 3:STAR
synonym: "an aromatic amino-acid" RELATED [uniprot_ft]
synonym: "aromatic amino-acid zwitterions" RELATED [chebi]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: RO:0018036 CHEBI:33856 ! aromatic amino acid

[Term]
id: CHEBI:76206
name: xenobiotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced by metabolism of a xenobiotic compound." []
subset: 3:STAR
synonym: "xenobiotic metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76395
name: EC 2.3.1.48 (histone acetyltransferase) inhibitor
namespace: chebi_ontology
def: "An  EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the function of histone acetyltransferase (EC 2.3.1.48)." []
subset: 3:STAR
synonym: "acetyl-CoA:histone acetyltransferase inhibitor" RELATED [chebi]
synonym: "acetyl-CoA:histone acetyltransferase inhibitors" RELATED [chebi]
synonym: "EC 2.3.1.48 (histone acetyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.3.1.48 inhibitor" RELATED [chebi]
synonym: "EC 2.3.1.48 inhibitors" RELATED [chebi]
synonym: "HAT inhibitor" RELATED [chebi]
synonym: "HAT inhibitors" RELATED [chebi]
synonym: "histone acetokinase inhibitor" RELATED [chebi]
synonym: "histone acetokinase inhibitors" RELATED [chebi]
synonym: "histone acetylase inhibitor" RELATED [chebi]
synonym: "histone acetylase inhibitors" RELATED [chebi]
synonym: "histone acetyltransferase (EC 2.3.1.48) inhibitor" RELATED [chebi]
synonym: "histone acetyltransferase (EC 2.3.1.48) inhibitors" RELATED [chebi]
synonym: "histone acetyltransferase inhibitor" RELATED [chebi]
synonym: "histone acetyltransferase inhibitors" RELATED [chebi]
synonym: "histone transacetylase inhibitor" RELATED [chebi]
synonym: "histone transacetylase inhibitors" RELATED [chebi]
synonym: "nucleosome-histone acetyltransferase inhibitor" RELATED [chebi]
synonym: "nucleosome-histone acetyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76878 ! EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor

[Term]
id: CHEBI:76507
name: marine metabolite
namespace: chebi_ontology
alt_id: CHEBI:77078
def: "Any metabolite produced during a metabolic reaction in marine macro- and microorganisms." []
subset: 3:STAR
synonym: "marine metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76567
name: polyunsaturated fatty acid anion
namespace: chebi_ontology
def: "Any unsaturated fatty acid anion containing more than one C-C unsaturated bond.  Major species at pH 7.3." []
subset: 3:STAR
synonym: "polyunsaturated fatty acid anions" RELATED [chebi]
synonym: "PUFA" RELATED [submitter]
is_a: CHEBI:2580 ! unsaturated fatty acid anion
relationship: RO:0018033 CHEBI:26208 ! polyunsaturated fatty acid

[Term]
id: CHEBI:7660
name: nystatin
namespace: chebi_ontology
def: "A heterogeneous mixture of polyene compounds produced by cultures of <em>Streptomyces noursei</em>. It mainly consists of three biologically active components designated nystatin A<small><sub>1</sub></small>, nystatin A<small><sub>2</sub></small>, and nystatin A<small><sub>3</sub></small>. It is used to treat oral and dermal fungal infections." []
subset: 3:STAR
is_a: CHEBI:22507 ! aminoglycoside antibiotic
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:26191 ! polyol
is_a: CHEBI:36244 ! dicarboxylic acid monoester
is_a: CHEBI:48121 ! polyene
is_a: CHEBI:60004 ! mixture
is_a: CHEBI:87113 ! antibiotic antifungal drug
relationship: BFO:0000051 CHEBI:192979 ! has part nystatin A2
relationship: BFO:0000051 CHEBI:31927 ! has part nystatin A3
relationship: BFO:0000051 CHEBI:473992 ! has part nystatin A1
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:76661
name: EC 2.3.* (acyltransferase) inhibitor
namespace: chebi_ontology
def: "A transferase inhibitor that interferes with the action of an acyltransferase (EC 2.3.*.*)." []
subset: 3:STAR
synonym: "acyltransferase inhibitor" RELATED [chebi]
synonym: "acyltransferase inhibitors" RELATED [chebi]
synonym: "EC 2.3.* (acyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.3.* inhibitor" RELATED [chebi]
synonym: "EC 2.3.* inhibitors" RELATED [chebi]
is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor

[Term]
id: CHEBI:76662
name: EC 2.4.* (glycosyltransferase) inhibitor
namespace: chebi_ontology
def: "A transferase inhibitor inhibiting the action of a glycosyltransferase (EC 2.4.*.*)." []
subset: 3:STAR
synonym: "EC 2.4.* (glycosyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.* inhibitor" RELATED [chebi]
synonym: "EC 2.4.* inhibitors" RELATED [chebi]
synonym: "glycosyltransferase (EC 2.4.*) inhibitor" RELATED [chebi]
synonym: "glycosyltransferase (EC 2.4.*) inhibitors" RELATED [chebi]
synonym: "glycosyltransferase inhibitor" RELATED [chebi]
synonym: "glycosyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor

[Term]
id: CHEBI:76663
name: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor
namespace: chebi_ontology
def: "A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*)." []
subset: 3:STAR
synonym: "alkyl/aryl (non-methyl) transferase inhibitor" RELATED [chebi]
synonym: "alkyl/aryl (non-methyl) transferase inhibitors" RELATED [chebi]
synonym: "EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [chebi]
synonym: "EC 2.5.1.* inhibitor" RELATED [chebi]
synonym: "EC 2.5.1.* inhibitors" RELATED [chebi]
synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor" RELATED [chebi]
synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors" RELATED [chebi]
synonym: "non-methyl alkyl/aryl transferase inhibitor" RELATED [chebi]
synonym: "non-methyl alkyl/aryl transferase inhibitors" RELATED [chebi]
synonym: "non-methyl-alkyl or aryl transferase inhibitor" RELATED [chebi]
synonym: "non-methyl-alkyl or aryl transferase inhibitors" RELATED [chebi]
is_a: CHEBI:76834 ! EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor

[Term]
id: CHEBI:76668
name: EC 2.7.* (P-containing group transferase) inhibitor
namespace: chebi_ontology
def: "A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*)." []
subset: 3:STAR
synonym: "EC 2.7.* (P-containing group transferase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitor" RELATED [chebi]
synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.* inhibitor" RELATED [chebi]
synonym: "EC 2.7.* inhibitors" RELATED [chebi]
synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitor" RELATED [chebi]
synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitors" RELATED [chebi]
synonym: "phosphorus-containing group transferase inhibitor" RELATED [chebi]
synonym: "phosphorus-containing group transferase inhibitors" RELATED [chebi]
is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor

[Term]
id: CHEBI:76697
name: EC 5.99.* (other isomerases) inhibitor
namespace: chebi_ontology
def: "An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*)." []
subset: 3:STAR
synonym: "EC 5.99.* (miscellaneous isomerases) inhibitor" RELATED [chebi]
synonym: "EC 5.99.* (miscellaneous isomerases) inhibitors" RELATED [chebi]
synonym: "EC 5.99.* (other isomerase) inhibitor" RELATED [chebi]
synonym: "EC 5.99.* (other isomerase) inhibitors" RELATED [chebi]
synonym: "EC 5.99.* (other isomerases) inhibitors" RELATED [chebi]
synonym: "EC 5.99.* inhibitor" RELATED [chebi]
synonym: "EC 5.99.* inhibitors" RELATED [chebi]
is_a: CHEBI:75596 ! EC 5.* (isomerase) inhibitor

[Term]
id: CHEBI:76710
name: EC 4.* (lyase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving <em>C</em>‒<em>C</em>, <em>C</em>‒<em>O</em>, <em>C</em>‒<em>N</em> and other bonds by other means than by hydrolysis or oxidation." []
subset: 3:STAR
synonym: "EC 4.* (lyase) inhibitors" RELATED [chebi]
synonym: "EC 4.* inhibitor" RELATED [chebi]
synonym: "EC 4.* inhibitors" RELATED [chebi]
synonym: "EC 4.*.*.* inhibitor" RELATED [chebi]
synonym: "EC 4.*.*.* inhibitors" RELATED [chebi]
synonym: "lyase (EC 4.*) inhibitor" RELATED [chebi]
synonym: "lyase (EC 4.*) inhibitorS" RELATED [chebi]
synonym: "lyase inhibitor" RELATED [chebi]
synonym: "lyase inhibitors" RELATED [chebi]
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76712
name: EC 4.2.* (C-O lyase) inhibitor
namespace: chebi_ontology
def: "A lyase inhibitor which inhibits the action of a <em>C</em>‒<em>O</em> lyase (EC 4.2.*.*)." []
subset: 3:STAR
synonym: "C-O lyase (EC 4.2.*) inhibitor" RELATED [chebi]
synonym: "C-O lyase (EC 4.2.*) inhibitors" RELATED [chebi]
synonym: "C-O lyase inhibitor" RELATED [chebi]
synonym: "C-O lyase inhibitors" RELATED [chebi]
synonym: "EC 4.2.* (C-O lyase) inhibitors" RELATED [chebi]
synonym: "EC 4.2.* inhibitor" RELATED [chebi]
synonym: "EC 4.2.* inhibitors" RELATED [chebi]
is_a: CHEBI:76710 ! EC 4.* (lyase) inhibitor

[Term]
id: CHEBI:76725
name: EC 1.* (oxidoreductase) inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." []
subset: 3:STAR
synonym: "EC 1.* (oxidoreductase) inhibitors" RELATED [chebi]
synonym: "EC 1.* inhibitor" RELATED [chebi]
synonym: "EC 1.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase (EC 1.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase (EC 1.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase inhibitor" RELATED [chebi]
synonym: "oxidoreductase inhibitors" RELATED [chebi]
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76727
name: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*)." []
subset: 3:STAR
synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor" RELATED [chebi]
synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors" RELATED [chebi]
synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors" RELATED [chebi]
synonym: "EC 1.2.* inhibitor" RELATED [chebi]
synonym: "EC 1.2.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76729
name: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*)." []
subset: 3:STAR
synonym: "EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors" RELATED [chebi]
synonym: "EC 1.3.* inhibitor" RELATED [chebi]
synonym: "EC 1.3.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-CH group of donor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-CH group of donors" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-CH group of donor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-CH group of donors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-CH group inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76730
name: EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH‒NH<small><sub>2</sub></small> group of donors (EC 1.4.*.*)." []
subset: 3:STAR
synonym: "EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor" RELATED [chebi]
synonym: "EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitors" RELATED [chebi]
synonym: "EC 1.4.* inhibitor" RELATED [chebi]
synonym: "EC 1.4.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-NH2 group of donor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-NH2 group of donors" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-NH2 group of donor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-NH2 group of donors" RELATED [chebi]
synonym: "oxidoreductase acting on CH-NH2 group of donor inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on CH-NH2 group of donor inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on CH-NH2 group of donors (EC 1.4.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76731
name: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*)." []
subset: 3:STAR
synonym: "EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors" RELATED [chebi]
synonym: "EC 1.5.* inhibitor" RELATED [chebi]
synonym: "EC 1.5.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-NH group of donor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-NH group of donors" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-NH group of donor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-NH group of donors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76733
name: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on  NADH or NADPH (EC 1.6.*.*)." []
subset: 3:STAR
synonym: "EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on NADH or NADPH" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on NADH or NADPH" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [chebi]
synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on NADH or NADPH inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on NADH or NADPH inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76736
name: EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on a heme group of donors (EC 1.9.*.*)." []
subset: 3:STAR
synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitor" RELATED [chebi]
synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors" RELATED [chebi]
synonym: "EC 1.9.* (oxidoreductase acting on donor heme group) inhibitors" RELATED [chebi]
synonym: "EC 1.9.* inhibitor" RELATED [chebi]
synonym: "EC 1.9.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76738
name: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on peroxide as donors (EC 1.11.*.*)." []
subset: 3:STAR
synonym: "EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitors" RELATED [chebi]
synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitor" RELATED [chebi]
synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors" RELATED [chebi]
synonym: "EC 1.11.* inhibitor" RELATED [chebi]
synonym: "EC 1.11.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76740
name: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*." []
subset: 3:STAR
synonym: "EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors" RELATED [chebi]
synonym: "EC 1.13.* inhibitor" RELATED [chebi]
synonym: "EC 1.13.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76741
name: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor
namespace: chebi_ontology
def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*)." []
subset: 3:STAR
synonym: "EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors" RELATED [chebi]
synonym: "EC 1.14.* inhibitor" RELATED [chebi]
synonym: "EC 1.14.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [chebi]
synonym: "inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [chebi]
synonym: "inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors" RELATED [chebi]
is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor

[Term]
id: CHEBI:76759
name: EC 3.* (hydrolase) inhibitor
namespace: chebi_ontology
def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." []
subset: 3:STAR
subset: 3_STAR
synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.* (hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.* inhibitor" RELATED [chebi]
synonym: "EC 3.* inhibitors" RELATED [chebi]
synonym: "EC 3.* inhibitors" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitor" RELATED [chebi]
synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitors" RELATED [chebi]
synonym: "hydrolase (EC 3.*) inhibitor" RELATED [chebi]
synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI]
synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI]
synonym: "hydrolase (EC 3.*) inhibitors" RELATED [chebi]
synonym: "hydrolase inhibitor" RELATED [ChEBI]
synonym: "hydrolase inhibitor" RELATED [chebi]
synonym: "hydrolase inhibitors" RELATED [ChEBI]
synonym: "hydrolase inhibitors" RELATED [chebi]
xref: Wikipedia:Hydrolase
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76760
name: EC 3.1.* (ester hydrolase) inhibitor
namespace: chebi_ontology
def: "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." []
subset: 3:STAR
synonym: "EC 3.1.* (ester hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.* inhibitor" RELATED [chebi]
synonym: "EC 3.1.* inhibitors" RELATED [chebi]
synonym: "ester hydrolase (EC 3.1.*) inhibitor" RELATED [chebi]
synonym: "ester hydrolase (EC 3.1.*) inhibitors" RELATED [chebi]
synonym: "ester hydrolase inhibitor" RELATED [chebi]
synonym: "ester hydrolase inhibitors" RELATED [chebi]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:76764
name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
namespace: chebi_ontology
def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." []
subset: 3:STAR
subset: 3_STAR
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [chebi]
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [chebi]
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [chebi]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [chebi]
synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [chebi]
synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitor" RELATED [chebi]
synonym: "EC 3.5.* inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitors" RELATED [chebi]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:76773
name: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*)." []
subset: 3:STAR
synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitor" RELATED [chebi]
synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitors" RELATED [chebi]
synonym: "EC 3.1.1.* (carboxylic ester hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.1.* inhibitor" RELATED [chebi]
synonym: "EC 3.1.1.* inhibitors" RELATED [chebi]
is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor

[Term]
id: CHEBI:76775
name: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*)." []
subset: 3:STAR
synonym: "EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.1.3.* inhibitor" RELATED [chebi]
synonym: "EC 3.1.3.* inhibitors" RELATED [chebi]
synonym: "inhibitor of phosphoric monoester hydrolase" RELATED [chebi]
synonym: "inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [chebi]
synonym: "inhibitors of phosphoric monoester hydrolase" RELATED [chebi]
synonym: "inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [chebi]
synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor" RELATED [chebi]
synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors" RELATED [chebi]
synonym: "phosphoric monoester hydrolase inhibitor" RELATED [chebi]
synonym: "phosphoric monoester hydrolase inhibitors" RELATED [chebi]
is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor

[Term]
id: CHEBI:76789
name: EC 2.4.1.* (hexosyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any hexosyltransferase (EC 2.4.1.*)." []
subset: 3:STAR
synonym: "EC 2.4.1.* (hexosyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.1.* inhibitor" RELATED [chebi]
synonym: "EC 2.4.1.* inhibitors" RELATED [chebi]
synonym: "hexosyltransferase (EC 2.4.1.*) inhibitor" RELATED [chebi]
synonym: "hexosyltransferase (EC 2.4.1.*) inhibitors" RELATED [chebi]
synonym: "hexosyltransferase inhibitor" RELATED [chebi]
synonym: "hexosyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76662 ! EC 2.4.* (glycosyltransferase) inhibitor

[Term]
id: CHEBI:76790
name: EC 2.4.2.* (pentosyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.4.* (glycosyltransferase) inhibitor that interferes with the action of any pentosyltransferase (EC 2.4.2.*)." []
subset: 3:STAR
synonym: "EC 2.4.2.* (pentosyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.4.2.* inhibitor" RELATED [chebi]
synonym: "EC 2.4.2.* inhibitors" RELATED [chebi]
synonym: "pentosyltransferase (EC 2.4.2.*) inhibitor" RELATED [chebi]
synonym: "pentosyltransferase (EC 2.4.2.*) inhibitors" RELATED [chebi]
synonym: "pentosyltransferase inhibitor" RELATED [chebi]
synonym: "pentosyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76662 ! EC 2.4.* (glycosyltransferase) inhibitor

[Term]
id: CHEBI:76807
name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." []
subset: 3:STAR
subset: 3_STAR
synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.1.* inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.* inhibitors" RELATED [chebi]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [chebi]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor

[Term]
id: CHEBI:76808
name: EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*)." []
subset: 3:STAR
synonym: "EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.2.* inhibitor" RELATED [chebi]
synonym: "EC 3.5.2.* inhibitors" RELATED [chebi]
synonym: "non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitor" RELATED [chebi]
synonym: "non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitors" RELATED [chebi]
synonym: "non-peptide cyclic amide C-N hydrolase inhibitor" RELATED [chebi]
synonym: "non-peptide cyclic amide C-N hydrolase inhibitors" RELATED [chebi]
is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor

[Term]
id: CHEBI:76812
name: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (<em>P</em>-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*)." []
subset: 3:STAR
synonym: "EC 2.7.11.* (protein-serine/threonine kinase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.11.* inhibitor" RELATED [chebi]
synonym: "EC 2.7.11.* inhibitors" RELATED [chebi]
synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitor" RELATED [chebi]
synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitors" RELATED [chebi]
synonym: "protein-serine/threonine kinase inhibitor" RELATED [chebi]
synonym: "protein-serine/threonine kinase inhibitors" RELATED [chebi]
is_a: CHEBI:37699 ! protein kinase inhibitor

[Term]
id: CHEBI:76815
name: EC 2.7.7.* (nucleotidyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (<em>P</em>-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*)." []
subset: 3:STAR
synonym: "EC 2.7.7.* (nucleotidyltransferase) inhibitors" RELATED [chebi]
synonym: "inhibitor of nucleotidyltransferases" RELATED [chebi]
synonym: "inhibitor of nucleotidyltransferases (EC 2.7.7.*)" RELATED [chebi]
synonym: "inhibitors of nucleotidyltransferases" RELATED [chebi]
synonym: "inhibitors of nucleotidyltransferases (EC 2.7.7.*)" RELATED [chebi]
synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitor" RELATED [chebi]
synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitors" RELATED [chebi]
synonym: "nucleotidyltransferase inhibitor" RELATED [chebi]
synonym: "nucleotidyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor

[Term]
id: CHEBI:76816
name: EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (<em>P</em>-containing group transferase) inhibitor that interferes with any enzyme in the EC 2.7.8.* (transferases for other substituted phosphate groups) category." []
subset: 3:STAR
synonym: "EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitors" RELATED [chebi]
synonym: "EC 2.7.8.* inhibitor" RELATED [chebi]
synonym: "EC 2.7.8.* inhibitors" RELATED [chebi]
is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor

[Term]
id: CHEBI:76830
name: EC 5.99.1.* (miscellaneous isomerase) inhibitor
namespace: chebi_ontology
def: "An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class." []
subset: 3:STAR
synonym: "EC 5.99.1.* (miscellaneous isomerase) inhibitors" RELATED [chebi]
synonym: "EC 5.99.1.* inhibitor" RELATED [chebi]
synonym: "EC 5.99.1.* inhibitors" RELATED [chebi]
is_a: CHEBI:76697 ! EC 5.99.* (other isomerases) inhibitor

[Term]
id: CHEBI:76834
name: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*)." []
subset: 3:STAR
synonym: "EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [chebi]
synonym: "EC 2.5.* inhibitor" RELATED [chebi]
synonym: "EC 2.5.* inhibitors" RELATED [chebi]
synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor" RELATED [chebi]
synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors" RELATED [chebi]
is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor

[Term]
id: CHEBI:76837
name: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor
namespace: chebi_ontology
def: "An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*)." []
subset: 3:STAR
synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor" RELATED [chebi]
synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors" RELATED [chebi]
synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors" RELATED [chebi]
synonym: "EC 1.13.11.* inhibitor" RELATED [chebi]
synonym: "EC 1.13.11.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76740 ! EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor

[Term]
id: CHEBI:76838
name: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor
namespace: chebi_ontology
def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*)." []
subset: 3:STAR
synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [chebi]
synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor" RELATED [chebi]
synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [chebi]
synonym: "EC 1.14.14.* inhibitor" RELATED [chebi]
synonym: "EC 1.14.14.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor

[Term]
id: CHEBI:76841
name: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
namespace: chebi_ontology
def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*)." []
subset: 3:STAR
synonym: "EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors" RELATED [chebi]
synonym: "EC 1.14.13.* inhibitor" RELATED [chebi]
synonym: "EC 1.14.13.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor

[Term]
id: CHEBI:76842
name: vancomycin(1+)
namespace: chebi_ontology
def: "An organic cation that is the conjugate acid of vancomycin, obtained by deprotonation of the carboxy group and protonation of the two amino functions; major species at pH 7.3." []
subset: 3:STAR
synonym: "vancomycin" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
relationship: RO:0018034 CHEBI:28001 ! vancomycin

[Term]
id: CHEBI:76853
name: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*)." []
subset: 3:STAR
synonym: "EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.2.3.* inhibitor" RELATED [chebi]
synonym: "EC 1.2.3.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76727 ! EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor

[Term]
id: CHEBI:76857
name: EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> as acceptor (EC 1.3.1.*)." []
subset: 3:STAR
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.* inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor

[Term]
id: CHEBI:76861
name: EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.4.* (oxidoreductase acting on donor CH-NH<small><sub>2</sub></small> group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.4.3.*)." []
subset: 3:STAR
synonym: "EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.4.3.* inhibitor" RELATED [chebi]
synonym: "EC 1.4.3.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76730 ! EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor

[Term]
id: CHEBI:76863
name: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> as acceptor (EC 1.5.1.*)." []
subset: 3:STAR
synonym: "EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.5.1.* inhibitor" RELATED [chebi]
synonym: "EC 1.5.1.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76731 ! EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor

[Term]
id: CHEBI:76866
name: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*)." []
subset: 3:STAR
synonym: "EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.6.5.* inhibitor" RELATED [chebi]
synonym: "EC 1.6.5.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76733 ! EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor

[Term]
id: CHEBI:76870
name: EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.9.3.*)." []
subset: 3:STAR
synonym: "EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.9.3.* inhibitor" RELATED [chebi]
synonym: "EC 1.9.3.* inhibitors" RELATED [chebi]
synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76736 ! EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor

[Term]
id: CHEBI:76878
name: EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor
namespace: chebi_ontology
def: "An EC 2.3.* (acyltransferase) inhibitor that inhibits the action of any acyltransferase transferring groups other than amino-acyl groups (EC 2.3.1.*)." []
subset: 3:STAR
synonym: "acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitor" RELATED [chebi]
synonym: "acyltransferase transferring other than amino-acyl group EC 2.3.1.* inhibitors" RELATED [chebi]
synonym: "EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors" RELATED [chebi]
synonym: "EC 2.3.1.* inhibitor" RELATED [chebi]
synonym: "EC 2.3.1.* inhibitors" RELATED [chebi]
is_a: CHEBI:76661 ! EC 2.3.* (acyltransferase) inhibitor

[Term]
id: CHEBI:76881
name: EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.* (<em>P</em>-containing group transferase) inhibitor that interferes with the action of any phosphotransferase with an alcohol group as acceptor (EC 2.7.1.*)." []
subset: 3:STAR
synonym: "EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 2.7.1.* inhibitor" RELATED [chebi]
synonym: "EC 2.7.1.* inhibitors" RELATED [chebi]
synonym: "phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitor" RELATED [chebi]
synonym: "phosphotransferases with an alcohol group as acceptor (EC 2.7.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor

[Term]
id: CHEBI:76895
name: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor
namespace: chebi_ontology
def: "An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*)." []
subset: 3:STAR
synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor" RELATED [chebi]
synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors" RELATED [chebi]
synonym: "EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors" RELATED [chebi]
synonym: "EC 3.6.3.* inhibitor" RELATED [chebi]
synonym: "EC 3.6.3.* inhibitors" RELATED [chebi]
is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor

[Term]
id: CHEBI:76898
name: EC 1.14.14.1 (unspecific monooxygenase) inhibitor
namespace: chebi_ontology
def: "An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1)." []
subset: 3:STAR
synonym: "aryl hydrocarbon hydroxylase inhibitor" RELATED [chebi]
synonym: "aryl hydrocarbon hydroxylase inhibitors" RELATED [chebi]
synonym: "aryl-4-monooxygenase inhibitor" RELATED [chebi]
synonym: "aryl-4-monooxygenase inhibitors" RELATED [chebi]
synonym: "EC 1.14.14.1 (unspecific monooxygenase) inhibitors" RELATED [chebi]
synonym: "EC 1.14.14.1 inhibitor" RELATED [chebi]
synonym: "EC 1.14.14.1 inhibitors" RELATED [chebi]
synonym: "flavoprotein monooxygenase inhibitor" RELATED [chebi]
synonym: "flavoprotein monooxygenase inhibitors" RELATED [chebi]
synonym: "flavoprotein-linked monooxygenase inhibitor" RELATED [chebi]
synonym: "flavoprotein-linked monooxygenase inhibitors" RELATED [chebi]
synonym: "microsomal monooxygenase inhibitor" RELATED [chebi]
synonym: "microsomal monooxygenase inhibitors" RELATED [chebi]
synonym: "microsomal P-450 inhibitor" RELATED [chebi]
synonym: "microsomal P-450 inhibitors" RELATED [chebi]
synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor" RELATED [chebi]
synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors" RELATED [chebi]
synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitor" RELATED [chebi]
synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitors" RELATED [chebi]
synonym: "unspecific monooxygenase inhibitor" RELATED [chebi]
synonym: "unspecific monooxygenase inhibitors" RELATED [chebi]
synonym: "xenobiotic monooxygenase inhibitor" RELATED [chebi]
synonym: "xenobiotic monooxygenase inhibitors" RELATED [chebi]
is_a: CHEBI:76838 ! EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor

[Term]
id: CHEBI:76907
name: EC 4.2.1.* (hydro-lyases) inhibitor
namespace: chebi_ontology
def: "An EC 4.2.* (<em>C</em>‒<em>O</em> lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*)." []
subset: 3:STAR
synonym: "EC 4.2.1.* (hydro-lyase) inhibitor" RELATED [chebi]
synonym: "EC 4.2.1.* (hydro-lyase) inhibitors" RELATED [chebi]
synonym: "EC 4.2.1.* (hydro-lyases) inhibitors" RELATED [chebi]
synonym: "EC 4.2.1.* inhibitor" RELATED [chebi]
synonym: "EC 4.2.1.* inhibitors" RELATED [chebi]
synonym: "hydro-lyase (EC 4.2.1.*) inhibitor" RELATED [chebi]
synonym: "hydro-lyase (EC 4.2.1.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76712 ! EC 4.2.* (C-O lyase) inhibitor

[Term]
id: CHEBI:76924
name: plant metabolite
namespace: chebi_ontology
alt_id: CHEBI:75766
alt_id: CHEBI:76925
def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." []
subset: 3:STAR
synonym: "plant metabolites" RELATED [chebi]
synonym: "plant secondary metabolites" RELATED [chebi]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:76932
name: pathway inhibitor
namespace: chebi_ontology
def: "An enzyme inhibitor that interferes with one or more steps in a metabolic pathway." []
subset: 3:STAR
synonym: "metabolic pathway inhibitor" RELATED [chebi]
synonym: "metabolic pathway inhibitors" RELATED [chebi]
synonym: "pathway inhibitors" RELATED [chebi]
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76946
name: fungal metabolite
namespace: chebi_ontology
alt_id: CHEBI:75765
alt_id: CHEBI:76947
def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." []
subset: 3:STAR
subset: 3_STAR
synonym: "fungal metabolites" RELATED [chebi]
synonym: "fungal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:76964
name: Penicillium metabolite
namespace: chebi_ontology
alt_id: CHEBI:76205
alt_id: CHEBI:76963
def: "Any fungal metabolite produced during a metabolic reaction in <em>Penicillium</em>." []
subset: 3:STAR
synonym: "Penicillium metabolites" RELATED [chebi]
is_a: CHEBI:76946 ! fungal metabolite

[Term]
id: CHEBI:76967
name: human xenobiotic metabolite
namespace: chebi_ontology
def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." []
subset: 3:STAR
synonym: "human xenobiotic metabolites" RELATED [chebi]
is_a: CHEBI:76206 ! xenobiotic metabolite
is_a: CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:76969
name: bacterial metabolite
namespace: chebi_ontology
alt_id: CHEBI:75760
alt_id: CHEBI:76970
def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." []
subset: 3:STAR
subset: 3_STAR
is_a: CHEBI:75787 ! prokaryotic metabolite

[Term]
id: CHEBI:76971
name: Escherichia coli metabolite
namespace: chebi_ontology
def: "Any bacterial metabolite produced during a metabolic reaction in <em>Escherichia coli</em>." []
subset: 3:STAR
subset: 3_STAR
synonym: "E.coli metabolite" RELATED [chebi]
synonym: "E.coli metabolite" RELATED [ChEBI]
synonym: "E.coli metabolites" RELATED [chebi]
synonym: "E.coli metabolites" RELATED [ChEBI]
synonym: "Escherichia coli metabolites" RELATED [chebi]
synonym: "Escherichia coli metabolites" RELATED [ChEBI]
is_a: CHEBI:76969 ! bacterial metabolite

[Term]
id: CHEBI:77047
name: tylosin(1+)
namespace: chebi_ontology
def: "An organic cation that is the conjugate acid of tylosin, obtained by protonation of the tertiary amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "tylosin" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:17658 ! tylosin

[Term]
id: CHEBI:77053
name: closantel
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections." []
subset: 3:STAR
synonym: "5'-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2',4'-salicyloxylidide" RELATED [chemidplus]
synonym: "R 31,520" RELATED [chemidplus]
synonym: "R 31520" RELATED [chemidplus]
is_a: CHEBI:60911 ! racemate
relationship: BFO:0000051 CHEBI:77056 ! has part (R)-closantel
relationship: BFO:0000051 CHEBI:77057 ! has part (S)-closantel
relationship: RO:0000087 CHEBI:35444 ! has role antinematodal drug

[Term]
id: CHEBI:77054
name: N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide
namespace: chebi_ontology
def: "An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively." []
subset: 3:STAR
is_a: CHEBI:18379 ! nitrile
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:37142 ! organoiodine compound
is_a: CHEBI:62733 ! aromatic amide
is_a: CHEBI:83403 ! monochlorobenzenes

[Term]
id: CHEBI:77056
name: (R)-closantel
namespace: chebi_ontology
def: "An <em>N</em>-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has <i>R</i> configuration." []
subset: 3:STAR
is_a: CHEBI:77054 ! N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide

[Term]
id: CHEBI:77057
name: (S)-closantel
namespace: chebi_ontology
def: "An <em>N</em>-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide that has <i>S</i> configuration." []
subset: 3:STAR
is_a: CHEBI:77054 ! N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide

[Term]
id: CHEBI:77102
name: EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor
namespace: chebi_ontology
def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the action of any such enzyme using a quinone or related compound as acceptor (EC 1.3.5.*)." []
subset: 3:STAR
synonym: "EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitors" RELATED [chebi]
synonym: "EC 1.3.5.* inhibitor" RELATED [chebi]
synonym: "EC 1.3.5.* inhibitors" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor" RELATED [chebi]
synonym: "inhibitor of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor" RELATED [chebi]
synonym: "inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*)" RELATED [chebi]
synonym: "oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitor" RELATED [chebi]
synonym: "oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor (EC 1.3.5.*) inhibitors" RELATED [chebi]
is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor

[Term]
id: CHEBI:77194
name: EC 2.7.1.33 (pantothenate kinase) inhibitor
namespace: chebi_ontology
def: "An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pantothenate kinase (EC 2.7.1.33)." []
subset: 3:STAR
synonym: "ATP:(R)-pantothenate 4'-phosphotransferase inhibitor" RELATED [chebi]
synonym: "ATP:(R)-pantothenate 4'-phosphotransferase inhibitors" RELATED [chebi]
synonym: "ATP:pantothenate 4'-phosphotransferase inhibitor" RELATED [chebi]
synonym: "ATP:pantothenate 4'-phosphotransferase inhibitors" RELATED [chebi]
synonym: "D-pantothenate kinase inhibitor" RELATED [chebi]
synonym: "D-pantothenate kinase inhibitors" RELATED [chebi]
synonym: "EC 2.7.1.33 (pantothenate kinase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.1.33 inhibitor" RELATED [chebi]
synonym: "EC 2.7.1.33 inhibitors" RELATED [chebi]
synonym: "pantothenate kinase (EC 2.7.1.33) inhibitor" RELATED [chebi]
synonym: "pantothenate kinase (EC 2.7.1.33) inhibitors" RELATED [chebi]
synonym: "pantothenate kinase (phosphorylating) inhibitor" RELATED [chebi]
synonym: "pantothenate kinase (phosphorylating) inhibitors" RELATED [chebi]
synonym: "pantothenic acid kinase inhibitor" RELATED [chebi]
synonym: "pantothenic acid kinase inhibitors" RELATED [chebi]
is_a: CHEBI:76881 ! EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor

[Term]
id: CHEBI:77255
name: EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor
namespace: chebi_ontology
def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83)." []
subset: 3:STAR
synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitor" RELATED [chebi]
synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors" RELATED [chebi]
synonym: "EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitors" RELATED [chebi]
synonym: "EC 3.4.24.83 inhibitor" RELATED [chebi]
synonym: "EC 3.4.24.83 inhibitors" RELATED [chebi]
synonym: "lethal toxin inhibitor" RELATED [chebi]
synonym: "lethal toxin inhibitors" RELATED [chebi]
is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor

[Term]
id: CHEBI:77308
name: ethylenebis(dithiocarbamate)
namespace: chebi_ontology
def: "A member of the class of dithiocarbamate anions resulting from the deprotonation of both of the dithiocarbamic acid moieties of ethylenebis(dithiocarbamic acid). The major species at pH 7.3." []
subset: 3:STAR
synonym: "ethylenebis(dithiocarbamic acid)(2-)" RELATED [chebi]
is_a: CHEBI:84292 ! dithiocarbamate anions
relationship: RO:0018033 CHEBI:83986 ! ethylenebis(dithiocarbamic acid)

[Term]
id: CHEBI:7731
name: ofloxacin
namespace: chebi_ontology
alt_id: CHEBI:100146
def: "A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication." []
subset: 3:STAR
synonym: "(+-)-ofloxacin" RELATED [chebi]
synonym: "(3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid" RELATED [iupac]
synonym: "DL 8280" RELATED [chemidplus]
synonym: "DL-8280" RELATED [chemidplus]
synonym: "HOE 280" RELATED [drugbank]
synonym: "HOE-280" RELATED [drugbank]
synonym: "OFLX" RELATED [kegg.drug]
synonym: "ORF 18489" RELATED [chemidplus]
synonym: "rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid" RELATED [chebi]
synonym: "rac-ofloxacin" RELATED [chebi]
synonym: "racemic ofloxacin" RELATED [chebi]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: BFO:0000051 CHEBI:46577 ! has part dextrofloxacin
relationship: BFO:0000051 CHEBI:63598 ! has part levofloxacin
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50750 ! has role EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor

[Term]
id: CHEBI:77315
name: spectinomycin(2+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the secondary amino groups of spectinomycin." []
subset: 3:STAR
synonym: "spectinomycin dication" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:146260 ! spectinomycin(1+)
relationship: RO:0018034 CHEBI:9215 ! spectinomycin

[Term]
id: CHEBI:77318
name: pregnane X receptor agonist
namespace: chebi_ontology
def: "An agonist that selectively binds to and activates a pregnane X receptor." []
subset: 3:STAR
synonym: "pregnane X receptor agonists" RELATED [chebi]
synonym: "PXR agonist" RELATED [chebi]
synonym: "PXR agonists" RELATED [chebi]
is_a: CHEBI:48705 ! agonist

[Term]
id: CHEBI:77569
name: trovafloxacin(1+)
namespace: chebi_ontology
def: "An organic cation that is the conjugate acid of trovafloxacin, obtained by protonation of the primary amino group." []
subset: 3:STAR
synonym: "trovafloxacin cation" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:9763 ! trovafloxacin

[Term]
id: CHEBI:77615
name: terbinafine(1+)
namespace: chebi_ontology
def: "An organic cation that is the conjugate acid of terbinafine, obtained by protonation of the amino group; major species at pH 7.3." []
subset: 3:STAR
synonym: "terbinafine cation" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:9448 ! terbinafine

[Term]
id: CHEBI:77718
name: carboxamidinium ion
namespace: chebi_ontology
def: "Any iminium ion resulting from the protonation of a carboxamidine." []
subset: 3:STAR
synonym: "carboxamidinium ions" RELATED [chebi]
is_a: CHEBI:35286 ! iminium ion

[Term]
id: CHEBI:77733
name: 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile
namespace: chebi_ontology
def: "A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group." []
subset: 3:STAR
is_a: CHEBI:18379 ! nitrile
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:46774 ! polyether
is_a: CHEBI:50996 ! tertiary amino compound

[Term]
id: CHEBI:77734
name: dexverapamil
namespace: chebi_ontology
def: "A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has <i>R</i> configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil." []
subset: 3:STAR
synonym: "(+)-(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [chebi]
synonym: "(+)-(R)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile" RELATED [chemidplus]
synonym: "(+)-(R)-verapamil" RELATED [chebi]
synonym: "(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [chebi]
synonym: "(+)-3-(3,4-dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile" RELATED [chebi]
synonym: "(+)-verapamil" RELATED [chebi]
synonym: "(2R)-(+)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [chebi]
synonym: "(R)-(+)-verapamil" RELATED [chebi]
synonym: "(R)-verapamil" RELATED [chebi]
is_a: CHEBI:77733 ! 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
relationship: RO:0018033 CHEBI:77737 ! dexverapamil(1+)
relationship: RO:0018039 CHEBI:77736 ! (S)-verapamil

[Term]
id: CHEBI:77736
name: (S)-verapamil
namespace: chebi_ontology
def: "A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has <i>S</i> configuration." []
subset: 3:STAR
synonym: "(-)-(S)-verapamil" RELATED [chebi]
synonym: "(-)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile" RELATED [chebi]
synonym: "(-)-verapamil" RELATED [chebi]
synonym: "(S)-(-)-verapamil" RELATED [chebi]
is_a: CHEBI:77733 ! 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
relationship: RO:0018033 CHEBI:77738 ! (S)-verapamil(1+)
relationship: RO:0018039 CHEBI:77734 ! dexverapamil

[Term]
id: CHEBI:77737
name: dexverapamil(1+)
namespace: chebi_ontology
def: "An ammonium ion resulting from the protonation of the tertiary amino group of dexverapamil." []
subset: 3:STAR
synonym: "(R)-verapamil(1+)" RELATED [chebi]
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:77734 ! dexverapamil
relationship: RO:0018039 CHEBI:77738 ! (S)-verapamil(1+)

[Term]
id: CHEBI:77738
name: (S)-verapamil(1+)
namespace: chebi_ontology
def: "An ammonium ion resulting from the protonation of the tertiary amino group of (<i>S</i>)-verapamil." []
subset: 3:STAR
synonym: "(S)-verapamil(1+)" RELATED [chebi]
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:77736 ! (S)-verapamil
relationship: RO:0018039 CHEBI:77737 ! dexverapamil(1+)

[Term]
id: CHEBI:77745
name: EC 3.4.24.18 (meprin A) inhibitor
namespace: chebi_ontology
def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that inhibits the action of meprin A (EC 3.4.24.18)." []
subset: 3:STAR
synonym: "EC 3.4.24.18 (meprin A) inhibitors" RELATED [chebi]
synonym: "EC 3.4.24.18 inhibitor" RELATED [chebi]
synonym: "EC 3.4.24.18 inhibitors" RELATED [chebi]
synonym: "endopeptidase-2 inhibitor" RELATED [chebi]
synonym: "endopeptidase-2 inhibitors" RELATED [chebi]
synonym: "meprin A (EC 3.4.24.18) inhibitor" RELATED [chebi]
synonym: "meprin A (EC 3.4.24.18) inhibitors" RELATED [chebi]
synonym: "meprin A inhibitor" RELATED [chebi]
synonym: "meprin A inhibitors" RELATED [chebi]
synonym: "meprin inhibitor" RELATED [chebi]
synonym: "meprin inhibitors" RELATED [chebi]
synonym: "meprin-a inhibitor" RELATED [chebi]
synonym: "meprin-a inhibitors" RELATED [chebi]
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitor" RELATED [chebi]
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitors" RELATED [chebi]
synonym: "PABA-peptide hydrolase inhibitor" RELATED [chebi]
synonym: "PABA-peptide hydrolase inhibitors" RELATED [chebi]
synonym: "PPH inhibitor" RELATED [chebi]
synonym: "PPH inhibitors" RELATED [chebi]
is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor

[Term]
id: CHEBI:77746
name: human metabolite
namespace: chebi_ontology
alt_id: CHEBI:75770
alt_id: CHEBI:77123
def: "Any mammalian metabolite  produced during a metabolic reaction in humans (<em>Homo sapiens</em>)." []
subset: 3:STAR
subset: 3_STAR
synonym: "H. sapiens metabolite" RELATED [ChEBI]
synonym: "H. sapiens metabolite" RELATED [chebi]
synonym: "H. sapiens metabolites" RELATED [chebi]
synonym: "H. sapiens metabolites" RELATED [ChEBI]
synonym: "Homo sapiens metabolite" RELATED [ChEBI]
synonym: "Homo sapiens metabolite" RELATED [chebi]
synonym: "Homo sapiens metabolites" RELATED [ChEBI]
synonym: "Homo sapiens metabolites" RELATED [chebi]
is_a: CHEBI:75768 ! mammalian metabolite

[Term]
id: CHEBI:77747
name: EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor
namespace: chebi_ontology
def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of phospholipid-translocating ATPase (EC 3.6.3.1)." []
subset: 3:STAR
synonym: "aminophospholipid-transporting ATPase inhibitor" RELATED [chebi]
synonym: "aminophospholipid-transporting ATPase inhibitors" RELATED [chebi]
synonym: "ATP phosphohydrolase (phospholipid-flipping) inhibitor" RELATED [chebi]
synonym: "ATP phosphohydrolase (phospholipid-flipping) inhibitors" RELATED [chebi]
synonym: "EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitors" RELATED [chebi]
synonym: "EC 3.6.3.1 inhibitor" RELATED [chebi]
synonym: "EC 3.6.3.1 inhibitors" RELATED [chebi]
synonym: "flippase inhibitor" RELATED [chebi]
synonym: "flippase inhibitors" RELATED [chebi]
synonym: "magnesium-ATPase inhibitor" RELATED [chebi]
synonym: "magnesium-ATPase inhibitors" RELATED [chebi]
synonym: "Mg(2)(+)-ATPase inhibitor" RELATED [chebi]
synonym: "Mg(2)(+)-ATPase inhibitors" RELATED [chebi]
synonym: "phospholipid-translocating ATPase (EC 3.6.3.1) inhibitor" RELATED [chebi]
synonym: "phospholipid-translocating ATPase (EC 3.6.3.1) inhibitors" RELATED [chebi]
synonym: "phospholipid-translocating ATPase inhibitor" RELATED [chebi]
synonym: "phospholipid-translocating ATPase inhibitors" RELATED [chebi]
synonym: "phospholipid-transporting ATPase inhibitor" RELATED [chebi]
synonym: "phospholipid-transporting ATPase inhibitors" RELATED [chebi]
is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor

[Term]
id: CHEBI:77748
name: EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
namespace: chebi_ontology
def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of xenobiotic-transporting ATPase (EC 3.6.3.44)." []
subset: 3:STAR
synonym: "ATP phosphohydrolase (steroid-exporting) inhibitor" RELATED [chebi]
synonym: "ATP phosphohydrolase (steroid-exporting) inhibitors" RELATED [chebi]
synonym: "ATP phosphohydrolase (xenobiotic-exporting) inhibitor" RELATED [chebi]
synonym: "ATP phosphohydrolase (xenobiotic-exporting) inhibitors" RELATED [chebi]
synonym: "EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitors" RELATED [chebi]
synonym: "EC 3.6.3.44 inhibitor" RELATED [chebi]
synonym: "EC 3.6.3.44 inhibitors" RELATED [chebi]
synonym: "MDR protein inhibitor" RELATED [chebi]
synonym: "MDR protein inhibitors" RELATED [chebi]
synonym: "multidrug-resistance protein inhibitor" RELATED [chebi]
synonym: "multidrug-resistance protein inhibitors" RELATED [chebi]
synonym: "P-glycoprotein inhibitor" RELATED [chebi]
synonym: "P-glycoprotein inhibitors" RELATED [chebi]
synonym: "PDR protein inhibitor" RELATED [chebi]
synonym: "PDR protein inhibitors" RELATED [chebi]
synonym: "pleiotropic-drug-resistance protein inhibitor" RELATED [chebi]
synonym: "pleiotropic-drug-resistance protein inhibitors" RELATED [chebi]
synonym: "steroid-transporting ATPase inhibitor" RELATED [chebi]
synonym: "steroid-transporting ATPase inhibitors" RELATED [chebi]
synonym: "xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor" RELATED [chebi]
synonym: "xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitors" RELATED [chebi]
synonym: "xenobiotic-transporting ATPase inhibitor" RELATED [chebi]
synonym: "xenobiotic-transporting ATPase inhibitors" RELATED [chebi]
is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor

[Term]
id: CHEBI:77853
name: persistent organic pollutant
namespace: chebi_ontology
def: "Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains." []
subset: 3:STAR
synonym: "persistent organic pollutants" RELATED [chebi]
synonym: "POP" RELATED [chebi]
synonym: "POPs" RELATED [chebi]
is_a: CHEBI:78298 ! environmental contaminant

[Term]
id: CHEBI:77884
name: EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
namespace: chebi_ontology
def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14α-demethylase)." []
subset: 3:STAR
synonym: "cytochrome P450 51 inhibitor" RELATED [chebi]
synonym: "cytochrome P450 51 inhibitors" RELATED [chebi]
synonym: "EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitors" RELATED [chebi]
synonym: "EC 1.14.13.70 inhibitor" RELATED [chebi]
synonym: "EC 1.14.13.70 inhibitors" RELATED [chebi]
synonym: "lanosterol 14-demethylase inhibitor" RELATED [chebi]
synonym: "lanosterol 14-demethylase inhibitors" RELATED [chebi]
synonym: "lanosterol 14alpha-demethylase inhibitor" RELATED [chebi]
synonym: "lanosterol 14alpha-demethylase inhibitors" RELATED [chebi]
synonym: "obtusufoliol 14-demethylase inhibitor" RELATED [chebi]
synonym: "obtusufoliol 14-demethylase inhibitors" RELATED [chebi]
synonym: "sterol 14-demethylase inhibitor" RELATED [chebi]
synonym: "sterol 14-demethylase inhibitors" RELATED [chebi]
synonym: "sterol 14alpha-demethylase inhibitor" RELATED [chebi]
synonym: "sterol 14alpha-demethylase inhibitors" RELATED [chebi]
synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitor" RELATED [chebi]
synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) inhibitors" RELATED [chebi]
is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor
is_a: CHEBI:83734 ! sterol demethylation inhibitor

[Term]
id: CHEBI:77906
name: minocycline zwitterion
namespace: chebi_ontology
def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of minocycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." []
subset: 3:STAR
synonym: "minocycline" RELATED [uniprot_ft]
is_a: CHEBI:144644 ! a tetracycline zwitterion
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0018034 CHEBI:71337 ! minocycline(1-)
relationship: RO:0018036 CHEBI:50694 ! minocycline

[Term]
id: CHEBI:77932
name: tetracycline zwitterion
namespace: chebi_ontology
def: "A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of tetracycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." []
subset: 3:STAR
synonym: "tetracycline" RELATED [uniprot_ft]
is_a: CHEBI:144644 ! a tetracycline zwitterion
is_a: CHEBI:27369 ! zwitterion
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:48001 ! has role protein synthesis inhibitor
relationship: RO:0018034 CHEBI:71392 ! tetracycline(1-)
relationship: RO:0018036 CHEBI:27902 ! tetracycline

[Term]
id: CHEBI:77941
name: EC 3.5.1.4 (amidase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." []
subset: 3:STAR
subset: 3_STAR
synonym: "acylamidase inhibitor" RELATED [chebi]
synonym: "acylamidase inhibitor" RELATED [ChEBI]
synonym: "acylamidase inhibitors" RELATED [chebi]
synonym: "acylamidase inhibitors" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitor" RELATED [chebi]
synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitors" RELATED [chebi]
synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI]
synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [chebi]
synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [chebi]
synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI]
synonym: "amidase inhibitor" RELATED [chebi]
synonym: "amidase inhibitor" RELATED [ChEBI]
synonym: "amidase inhibitors" RELATED [ChEBI]
synonym: "amidase inhibitors" RELATED [chebi]
synonym: "amidohydrolase inhibitor" RELATED [ChEBI]
synonym: "amidohydrolase inhibitor" RELATED [chebi]
synonym: "amidohydrolase inhibitors" RELATED [chebi]
synonym: "amidohydrolase inhibitors" RELATED [ChEBI]
synonym: "deaminase inhibitor" RELATED [ChEBI]
synonym: "deaminase inhibitor" RELATED [chebi]
synonym: "deaminase inhibitors" RELATED [chebi]
synonym: "deaminase inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.4 inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.1.4 inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI]
synonym: "fatty acylamidase inhibitor" RELATED [chebi]
synonym: "fatty acylamidase inhibitor" RELATED [ChEBI]
synonym: "fatty acylamidase inhibitors" RELATED [chebi]
synonym: "fatty acylamidase inhibitors" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitor" RELATED [chebi]
synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitors" RELATED [chebi]
xref: Wikipedia:Amidase
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:77981
name: vancomycin aglycone(1-)
namespace: chebi_ontology
def: "A peptide anion that is the conjugate base of vancomycin aglycone and the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." []
subset: 3:STAR
synonym: "vancomycin aglycone" RELATED [uniprot_ft]
is_a: CHEBI:50525 ! phenolate anion
is_a: CHEBI:60334 ! peptide anion
relationship: RO:0018033 CHEBI:47724 ! vancomycin aglycone
relationship: RO:0018033 CHEBI:75954 ! vancomycin aglycone zwitterion

[Term]
id: CHEBI:7809
name: oxacillin
namespace: chebi_ontology
def: "A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6β." []
subset: 3:STAR
synonym: "(2S,5R,6R)-3,3-dimethyl-6-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "(5-methyl-3-phenyl-4-isoxazolyl)penicillin" RELATED [chemidplus]
synonym: "5-methyl-3-phenyl-4-isoxazolyl-penicillin" RELATED [chemidplus]
synonym: "6beta-(5-methyl-3-phenylisoxazol-4-yl)penicillanic acid" RELATED [chebi]
synonym: "Oxacillin" RELATED [kegg.compound]
synonym: "oxazocillin" RELATED [chemidplus]
is_a: CHEBI:17334 ! penicillin
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:52132 ! oxacillin(1-)

[Term]
id: CHEBI:78128
name: fatty acid anion 24:0
namespace: chebi_ontology
def: "Any saturated fatty acid anion containing 24 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3." []
subset: 3:STAR
synonym: "fatty acid 24:0" RELATED [uniprot_ft]
is_a: CHEBI:58953 ! saturated fatty acid anion

[Term]
id: CHEBI:78295
name: food component
namespace: chebi_ontology
def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." []
subset: 3:STAR
subset: 3_STAR
synonym: "dietary component" RELATED [ChEBI]
synonym: "dietary component" RELATED [chebi]
synonym: "dietary components" RELATED [chebi]
synonym: "dietary components" RELATED [ChEBI]
synonym: "food components" RELATED [chebi]
synonym: "food components" RELATED [ChEBI]
is_a: CHEBI:52211 ! physiological role

[Term]
id: CHEBI:78298
name: environmental contaminant
namespace: chebi_ontology
def: "Any minor or unwanted substance introduced into the environment that can have undesired effects." []
subset: 3:STAR
synonym: "environmental contaminants" RELATED [chebi]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:78379
name: EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
namespace: chebi_ontology
def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of UDP-<em>N</em>-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7)." []
subset: 3:STAR
synonym: "EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitors" RELATED [chebi]
synonym: "EC 2.5.1.7 inhibitor" RELATED [chebi]
synonym: "EC 2.5.1.7 inhibitors" RELATED [chebi]
synonym: "enoylpyruvate transferase inhibitor" RELATED [chebi]
synonym: "enoylpyruvate transferase inhibitors" RELATED [chebi]
synonym: "MurA transferase inhibitor" RELATED [chebi]
synonym: "MurA transferase inhibitors" RELATED [chebi]
synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitor" RELATED [chebi]
synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase inhibitors" RELATED [chebi]
synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitor" RELATED [chebi]
synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase inhibitors" RELATED [chebi]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitor" RELATED [chebi]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-alpha-D-glucosamine 1-carboxyvinyltransferase inhibitors" RELATED [chebi]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitor" RELATED [chebi]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase inhibitors" RELATED [chebi]
synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitor" RELATED [chebi]
synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase inhibitors" RELATED [chebi]
synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitor" RELATED [chebi]
synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase inhibitors" RELATED [chebi]
synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitor" RELATED [chebi]
synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase inhibitors" RELATED [chebi]
synonym: "pyruvate-UDP-acetylglucosamine transferase inhibitor" RELATED [chebi]
synonym: "pyruvate-UDP-acetylglucosamine transferase inhibitors" RELATED [chebi]
synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitor" RELATED [chebi]
synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase inhibitors" RELATED [chebi]
synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitor" RELATED [chebi]
synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitors" RELATED [chebi]
synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitor" RELATED [chebi]
synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitor" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) inhibitors" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyltransferase inhibitors" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitor" RELATED [chebi]
synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase inhibitors" RELATED [chebi]
is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor

[Term]
id: CHEBI:78433
name: refrigerant
namespace: chebi_ontology
def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." []
subset: 3:STAR
subset: 3_STAR
synonym: "refrigerants" RELATED [chebi]
synonym: "refrigerants" RELATED [ChEBI]
xref: Wikipedia:Refrigerant
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:78608
name: alpha-amino-acid zwitterion
namespace: chebi_ontology
alt_id: CHEBI:83409
def: "An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." []
subset: 3:STAR
subset: 3_STAR
synonym: "alpha-amino acid zwitterion" RELATED [chebi]
synonym: "alpha-amino acid zwitterion" RELATED [ChEBI]
synonym: "alpha-amino acid zwitterions" RELATED [chebi]
synonym: "alpha-amino acid zwitterions" RELATED [ChEBI]
synonym: "alpha-amino-acid zwitterions" RELATED [ChEBI]
synonym: "alpha-amino-acid zwitterions" RELATED [chebi]
synonym: "an alpha-amino acid" RELATED [uniprot_ft]
synonym: "an alpha-amino acid" RELATED [UniProt]
is_a: CHEBI:35238 ! amino-acid zwitterion
relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid
relationship: RO:0018036 CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:78616
name: carbohydrates and carbohydrate derivatives
namespace: chebi_ontology
def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>; carbohydrate derivatives may contain other elements by substitution or condensation." []
subset: 3:STAR
synonym: "carbohydrates and derivatives" RELATED [chebi]
synonym: "carbohydrates and their derivatives" RELATED [chebi]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:78675
name: fundamental metabolite
namespace: chebi_ontology
def: "Any metabolite produced by all living cells." []
subset: 3:STAR
synonym: "essential metabolite" RELATED [chebi]
synonym: "essential metabolites" RELATED [chebi]
synonym: "fundamental metabolites" RELATED [chebi]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:78692
name: 1-[biphenyl-4-yl(phenyl)methyl]imidazole
namespace: chebi_ontology
def: "A member of the class of imidazoles carrying an α-(biphenyl-4-yl)benzyl substituent at position 1." []
subset: 3:STAR
is_a: CHEBI:22888 ! biphenyls
is_a: CHEBI:24780 ! imidazoles

[Term]
id: CHEBI:78693
name: (R)-bifonazole
namespace: chebi_ontology
def: "A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the <i>R</i>-enantiomer of bifonazole." []
subset: 3:STAR
synonym: "(-)-bifonazole" RELATED [chebi]
synonym: "(R)-(-)-bifonazole" RELATED [chebi]
is_a: CHEBI:78692 ! 1-[biphenyl-4-yl(phenyl)methyl]imidazole
relationship: RO:0018039 CHEBI:78694 ! (S)-bifonazole

[Term]
id: CHEBI:78694
name: (S)-bifonazole
namespace: chebi_ontology
def: "A 1-[biphenyl-4-yl(phenyl)methyl]imidazole that is the <i>S</i>-enantiomer of bifonazole." []
subset: 3:STAR
synonym: "(+)-bifonazole" RELATED [chebi]
synonym: "(S)-(+)-bifonazole" RELATED [chebi]
is_a: CHEBI:78692 ! 1-[biphenyl-4-yl(phenyl)methyl]imidazole
relationship: RO:0018039 CHEBI:78693 ! (R)-bifonazole

[Term]
id: CHEBI:78696
name: cercosporamide
namespace: chebi_ontology
def: "A member of the class of dibenzofurans that is a potent broad spectrum antifungal agent isolated from the fungus <em>Cercosporidium henningsii</em>." []
subset: 3:STAR
is_a: CHEBI:26195 ! polyphenol
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:38922 ! dibenzofurans
is_a: CHEBI:51867 ! methyl ketone
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:38231 ! has role phytotoxin
relationship: RO:0000087 CHEBI:76946 ! has role fungal metabolite
relationship: RO:0000087 CHEBI:79091 ! has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor

[Term]
id: CHEBI:78787
name: dithiocarbamic acids
namespace: chebi_ontology
def: "Any organic acid in which both oxygens of a carbamic acid have been replaced by sulfur." []
subset: 3:STAR
synonym: "dithiocarbamic acid" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:50492 ! thiocarbonyl compound
is_a: CHEBI:64709 ! organic acid
relationship: RO:0018034 CHEBI:84292 ! dithiocarbamate anions

[Term]
id: CHEBI:78840
name: olefinic compound
namespace: chebi_ontology
def: "Any organic molecular entity that contains at least one C=C bond." []
subset: 3:STAR
synonym: "olefinic compounds" RELATED [chebi]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:79020
name: alpha,beta-unsaturated monocarboxylic acid
namespace: chebi_ontology
def: "A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C≡C bond." []
subset: 3:STAR
synonym: "2,3-unsaturated monocarboxylic acid" RELATED [chebi]
synonym: "2,3-unsaturated monocarboxylic acids" RELATED [chebi]
synonym: "alpha,beta-unsaturated monocarboxylic acids" RELATED [chebi]
is_a: CHEBI:25384 ! monocarboxylic acid

[Term]
id: CHEBI:79091
name: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
namespace: chebi_ontology
alt_id: CHEBI:75997
def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24)." []
subset: 3:STAR
synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitor" RELATED [chebi]
synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitors" RELATED [chebi]
synonym: "c-Jun N-terminal kinase inhibitor" RELATED [chebi]
synonym: "c-Jun N-terminal kinase inhibitors" RELATED [chebi]
synonym: "Dp38 inhibitor" RELATED [chebi]
synonym: "Dp38 inhibitors" RELATED [chebi]
synonym: "EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors" RELATED [chebi]
synonym: "EC 2.7.11.24 inhibitor" RELATED [chebi]
synonym: "EC 2.7.11.24 inhibitors" RELATED [chebi]
synonym: "ERK inhibitor" RELATED [chebi]
synonym: "ERK inhibitors" RELATED [chebi]
synonym: "ERK1 inhibitor" RELATED [chebi]
synonym: "ERK1 inhibitors" RELATED [chebi]
synonym: "ERK2 inhibitor" RELATED [chebi]
synonym: "ERK2 inhibitors" RELATED [chebi]
synonym: "extracellular signal-regulated kinase inhibitor" RELATED [chebi]
synonym: "extracellular signal-regulated kinase inhibitors" RELATED [chebi]
synonym: "JNK inhibitor" RELATED [chebi]
synonym: "JNK inhibitors" RELATED [chebi]
synonym: "JNK3alpha1 inhibitor" RELATED [chebi]
synonym: "JNK3alpha1 inhibitors" RELATED [chebi]
synonym: "LeMPK3 inhibitor" RELATED [chebi]
synonym: "LeMPK3 inhibitors" RELATED [chebi]
synonym: "MAP kinase inhibitor" RELATED [chebi]
synonym: "MAP kinase inhibitors" RELATED [chebi]
synonym: "MAP-2 kinase inhibitor" RELATED [chebi]
synonym: "MAP-2 kinase inhibitors" RELATED [chebi]
synonym: "MAPK inhibitor" RELATED [chebi]
synonym: "MAPK inhibitors" RELATED [chebi]
synonym: "MBP kinase I inhibitor" RELATED [chebi]
synonym: "MBP kinase I inhibitors" RELATED [chebi]
synonym: "MBP kinase II inhibitor" RELATED [chebi]
synonym: "MBP kinase II inhibitors" RELATED [chebi]
synonym: "MEK inhibitor" RELATED [chebi]
synonym: "MEK inhibitors" RELATED [chebi]
synonym: "microtubule-associated protein 2 kinase inhibitor" RELATED [chebi]
synonym: "microtubule-associated protein 2 kinase inhibitors" RELATED [chebi]
synonym: "microtubule-associated protein kinase inhibitor" RELATED [chebi]
synonym: "microtubule-associated protein kinase inhibitors" RELATED [chebi]
synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitor" RELATED [chebi]
synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitors" RELATED [chebi]
synonym: "mitogen-activated protein kinase inhibitor" RELATED [chebi]
synonym: "mitogen-activated protein kinase inhibitors" RELATED [chebi]
synonym: "myelin basic protein kinase inhibitor" RELATED [chebi]
synonym: "myelin basic protein kinase inhibitors" RELATED [chebi]
synonym: "p38-2 inhibitor" RELATED [chebi]
synonym: "p38-2 inhibitors" RELATED [chebi]
synonym: "p38delta inhibitor" RELATED [chebi]
synonym: "p38delta inhibitors" RELATED [chebi]
synonym: "p42 mitogen-activated protein kinase inhibitor" RELATED [chebi]
synonym: "p42 mitogen-activated protein kinase inhibitors" RELATED [chebi]
synonym: "p42(mapk) inhibitor" RELATED [chebi]
synonym: "p42(mapk) inhibitors" RELATED [chebi]
synonym: "p44mpk inhibitor" RELATED [chebi]
synonym: "p44mpk inhibitors" RELATED [chebi]
synonym: "PMK-1 inhibitor" RELATED [chebi]
synonym: "PMK-1 inhibitors" RELATED [chebi]
synonym: "PMK-2 inhibitor" RELATED [chebi]
synonym: "PMK-2 inhibitors" RELATED [chebi]
synonym: "PMK-3 inhibitor" RELATED [chebi]
synonym: "PMK-3 inhibitors" RELATED [chebi]
synonym: "pp42 inhibitor" RELATED [chebi]
synonym: "pp42 inhibitors" RELATED [chebi]
synonym: "pp44(mapk) inhibitor" RELATED [chebi]
synonym: "pp44(mapk) inhibitors" RELATED [chebi]
synonym: "SAPK inhibitor" RELATED [chebi]
synonym: "SAPK inhibitors" RELATED [chebi]
synonym: "STK26 inhibitor" RELATED [chebi]
synonym: "STK26 inhibitors" RELATED [chebi]
synonym: "stress-activated protein kinase inhibitor" RELATED [chebi]
synonym: "stress-activated protein kinase inhibitors" RELATED [chebi]
is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor

[Term]
id: CHEBI:79092
name: EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor
namespace: chebi_ontology
def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any such enzyme using H<small><sub>2</sub></small>O<small><sub>2</sub></small> as acceptor and incorporating one oxygen atom of the H<small><sub>2</sub></small>O<small><sub>2</sub></small> into the product (EC 1.11.2.*)." []
subset: 3:STAR
synonym: "EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitors" RELATED [chebi]
synonym: "EC 1.11.2.* inhibitor" RELATED [chebi]
synonym: "EC 1.11.2.* inhibitors" RELATED [chebi]
is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor

[Term]
id: CHEBI:79093
name: EC 1.11.2.2 (myeloperoxidase) inhibitor
namespace: chebi_ontology
def: "An EC 1.11.2.* (oxidoreductase with H<small><sub>2</sub></small>O<small><sub>2</sub></small> as acceptor, incorporating 1 O atom into product) inhibitor that interferes with the action of myeloperoxidase (EC 1.11.2.2)." []
subset: 3:STAR
synonym: "chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitor" RELATED [chebi]
synonym: "chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitors" RELATED [chebi]
synonym: "EC 1.11.2.2 (myeloperoxidase) inhibitors" RELATED [chebi]
synonym: "EC 1.11.2.2 inhibitor" RELATED [chebi]
synonym: "EC 1.11.2.2 inhibitors" RELATED [chebi]
synonym: "MPO inhibitor" RELATED [chebi]
synonym: "MPO inhibitors" RELATED [chebi]
synonym: "myeloperoxidase (EC 1.11.2.2) inhibitor" RELATED [chebi]
synonym: "myeloperoxidase (EC 1.11.2.2) inhibitors" RELATED [chebi]
synonym: "myeloperoxidase inhibitor" RELATED [chebi]
synonym: "myeloperoxidase inhibitors" RELATED [chebi]
synonym: "verdoperoxidase inhibitor" RELATED [chebi]
synonym: "verdoperoxidase inhibitors" RELATED [chebi]
is_a: CHEBI:79092 ! EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor

[Term]
id: CHEBI:79314
name: flame retardant
namespace: chebi_ontology
def: "Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire." []
subset: 3:STAR
synonym: "flame retardants" RELATED [chebi]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:7934
name: paromomycin
namespace: chebi_ontology
alt_id: CHEBI:44703
def: "An amino cyclitol glycoside that is the 1-<em>O</em>-(2-amino-2-deoxy-α-<small>D</small>-glucopyranoside) and the 3-<em>O</em>-(2,6-diamino-2,6-dideoxy-β-<small>L</small>-idopyranosyl)-β-<small>D</small>-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1<i>R</i>,2<i>R</i>,3<i>S</i>,4<i>R</i>,6<i>S</i> diastereoisomer). It is obtained from various <em>Streptomyces</em> species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis." []
subset: 3:STAR
synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside" EXACT [PDBeChem]
synonym: "(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside" RELATED [pdb-ccd]
synonym: "Aminosidin" RELATED [kegg.compound]
synonym: "aminosidine" RELATED [chemidplus]
synonym: "Catenulin" RELATED [kegg.compound]
synonym: "crestomycin" RELATED [chemidplus]
synonym: "estomycin" RELATED [chemidplus]
synonym: "Hydroxymycin" RELATED [kegg.compound]
synonym: "hydroxymycin" RELATED [chemidplus]
synonym: "Monomycin A" RELATED [kegg.compound]
synonym: "Neomycin E" RELATED [kegg.compound]
synonym: "neomycin E" RELATED [chemidplus]
synonym: "PAROMOMYCIN" RELATED [pdb-ccd]
synonym: "Paromomycin" RELATED [kegg.compound]
synonym: "Paromomycin I" RELATED [kegg.compound]
synonym: "paucimycin" RELATED [chemidplus]
synonym: "paucimycinum" RELATED [chemidplus]
synonym: "R 400" RELATED [chemidplus]
synonym: "R-400" RELATED [chebi]
synonym: "Zygomycin A1" RELATED [kegg.compound]
is_a: CHEBI:22479 ! amino cyclitol glycoside
is_a: CHEBI:22507 ! aminoglycoside antibiotic
relationship: RO:0000087 CHEBI:35443 ! has role anthelminthic drug
relationship: RO:0000087 CHEBI:35820 ! has role antiprotozoal drug
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018033 CHEBI:233202 ! paromomycin(5+)
relationship: RO:0018038 CHEBI:27955 ! streptamine

[Term]
id: CHEBI:79387
name: trivalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of three." []
subset: 3:STAR
synonym: "trivalent inorganic anions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:79388
name: divalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of two." []
subset: 3:STAR
subset: 3_STAR
synonym: "divalent inorganic anions" RELATED [chebi]
synonym: "divalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:79389
name: monovalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of one." []
subset: 3:STAR
subset: 3_STAR
synonym: "monovalent inorganic anions" RELATED [ChEBI]
synonym: "monovalent inorganic anions" RELATED [chebi]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:81758
name: cyproconazole
namespace: chebi_ontology
def: "A diastereoisomeric mixture composed of the enantiomeric pair (2<i>R</i>,3<i>S</i>)- and (2<i>S</i>,3<i>R</i>)-cyproconazole in ratio 1:1 with the enantiomeric pair (2<i>R</i>,3<i>R</i>)- and (2<i>S</i>,3<i>S</i>)-cyproconazole. A broad spectrum fungicide, it is used on cereals and other field crops used to control Septoria, rust, powdery mildew and other diseases." []
subset: 3:STAR
synonym: "alpha-(4-chlorophenyl)-alpha-(1-cyclopropylethyl)-1N-1,2,4-triazole-1-ethanol" RELATED [pesticides]
is_a: CHEBI:60915 ! diastereoisomeric mixture
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: BFO:0000051 CHEBI:83749 ! has part (2R,3S)-cyproconazole
relationship: BFO:0000051 CHEBI:83750 ! has part (2S,3S)-cyproconazole
relationship: BFO:0000051 CHEBI:83752 ! has part (2S,3R)-cyproconazole
relationship: BFO:0000051 CHEBI:83753 ! has part (2R,3R)-cyproconazole
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81760
name: difenoconazole
namespace: chebi_ontology
def: "A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups.  A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms." []
subset: 3:STAR
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:39430 ! dioxolane
is_a: CHEBI:59779 ! cyclic ketal
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81763
name: fludioxonil
namespace: chebi_ontology
def: "A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including <em>Fusarium</em>, <em>Rhizoctonia</em> and <em>Alternaria </em>." []
subset: 3:STAR
is_a: CHEBI:18379 ! nitrile
is_a: CHEBI:26455 ! pyrroles
is_a: CHEBI:37143 ! organofluorine compound
is_a: CHEBI:38298 ! benzodioxoles
relationship: RO:0000087 CHEBI:35497 ! has role androgen antagonist
relationship: RO:0000087 CHEBI:63951 ! has role estrogen receptor agonist
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81781
name: tebuconazole
namespace: chebi_ontology
alt_id: CHEBI:83566
def: "A racemate composed of equimolar amounts of (<i>R</i>)- and (<i>S</i>)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops." []
subset: 3:STAR
synonym: "(RS)-1-p-chlorophenyl-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol" RELATED [pesticides]
synonym: "Ethyltrianol" RELATED [chemidplus]
synonym: "Fenetrazole" RELATED [chemidplus]
synonym: "Terbuconazole" RELATED [chemidplus]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: BFO:0000051 CHEBI:83780 ! has part (S)-tebuconazole
relationship: BFO:0000051 CHEBI:83781 ! has part (R)-tebuconazole
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81783
name: tricyclazole
namespace: chebi_ontology
def: "A triazolobenzothiazole that is [1,2,4]triazolo[3,4-<em>b</em>][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union." []
subset: 3:STAR
synonym: "5-methyl-1,2,4-triazolo[3,4-b]benzothiazole" RELATED [pesticides]
synonym: "5-methyl-striazolo-[3,4-b]benzothiazole" RELATED [chebi]
is_a: CHEBI:48908 ! triazolobenzothiazole
relationship: RO:0000087 CHEBI:64933 ! has role melanin synthesis inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018033 CHEBI:41032 ! 5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazol-1-ium

[Term]
id: CHEBI:81822
name: boscalid
namespace: chebi_ontology
def: "A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including <em>Botrytis</em> spp., <em>Alternaria</em> spp. and <em>Sclerotinia</em> spp. for use on a wide range of crops including fruit, vegetables and ornamentals." []
subset: 3:STAR
synonym: "2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide" RELATED [pesticides]
synonym: "2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide" RELATED [pesticides]
is_a: CHEBI:22888 ! biphenyls
is_a: CHEBI:25529 ! pyridinecarboxamide
is_a: CHEBI:83403 ! monochlorobenzenes
is_a: CHEBI:87015 ! anilide fungicide
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:83072 ! has role EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018038 CHEBI:15940 ! nicotinic acid

[Term]
id: CHEBI:81853
name: fenhexamid
namespace: chebi_ontology
def: "An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol." []
subset: 3:STAR
synonym: "2',3'-dichloro-4'-hydroxy-1-methylcyclohexanecarboxanilide" RELATED [chebi]
synonym: "fenhexamide" RELATED [chebi]
synonym: "KBR 2738" RELATED [chemidplus]
synonym: "KBR-2738" RELATED [chebi]
synonym: "N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexane-1-carboxamide" RELATED [pesticides]
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:29347 ! monocarboxylic acid amide
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:62733 ! aromatic amide
is_a: CHEBI:87015 ! anilide fungicide
relationship: RO:0000087 CHEBI:83316 ! has role EC 1.14.13.72 (methylsterol monooxygenase) inhibitor
relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81913
name: diniconazole
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts." []
subset: 3:STAR
synonym: "(+-)-diniconazole" RELATED [chebi]
synonym: "(betaE)-beta-[(2,4-dichlorophenyl)methylene]-alpha-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol" RELATED [pesticides]
synonym: "(E)-1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol" RELATED [chemidplus]
synonym: "(RS)-diniconazole" RELATED [chebi]
synonym: "1-(2,4-Dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol" RELATED [nist]
synonym: "rac-diniconazole" RELATED [chebi]
synonym: "racemic diniconazole" RELATED [chebi]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: BFO:0000051 CHEBI:83906 ! has part (S)-diniconazole
relationship: BFO:0000051 CHEBI:83911 ! has part diniconazole-M
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81917
name: fenpropidin
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-fenpropidin. A systemic fungicide, it is used for the control of foliar diseases in cereals and sugar beet." []
subset: 3:STAR
synonym: "(+-)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" RELATED [chebi]
synonym: "(RS)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine" RELATED [chebi]
synonym: "fenpropidine" RELATED [chemidplus]
synonym: "Ro 12-3049" RELATED [chemidplus]
synonym: "Ro-12-3049" RELATED [nist]
is_a: CHEBI:60911 ! racemate
relationship: BFO:0000051 CHEBI:83293 ! has part (R)-fenpropidin
relationship: BFO:0000051 CHEBI:83294 ! has part (S)-fenpropidin
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor
relationship: RO:0000087 CHEBI:83319 ! has role EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:81923
name: flutriafol
namespace: chebi_ontology
def: "A racemate comprising an equimolar mixture of (<i>R</i>)- and (<i>S</i>)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops." []
subset: 3:STAR
synonym: "(+-)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol" RELATED [chebi]
synonym: "(+-)-flutriafol" RELATED [chebi]
synonym: "(RS)-2,4'-difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol" RELATED [pesticides]
synonym: "alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol" RELATED [pesticides]
synonym: "PP 450" RELATED [nist]
synonym: "R 152450" RELATED [nist]
synonym: "rac flutriafol" RELATED [chebi]
synonym: "rac-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol" RELATED [pesticides]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: BFO:0000051 CHEBI:83708 ! has part (R)-flutriafol
relationship: BFO:0000051 CHEBI:83709 ! has part (S)-flutriafol
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:8232
name: piperacillin
namespace: chebi_ontology
alt_id: CHEBI:472443
alt_id: CHEBI:475140
alt_id: CHEBI:505944
def: "A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "Piperacillin" RELATED [kegg.compound]
synonym: "Piperacillin anhydrous" RELATED [kegg.compound]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:52433 ! piperacillin(1-)

[Term]
id: CHEBI:8269
name: Pleuromutilin
namespace: chebi_ontology
subset: 2:STAR
synonym: "Pleuromutilin" RELATED [kegg.compound]
is_a: CHEBI:33308 ! carboxylic ester
is_a: CHEBI:38032 ! carbotricyclic compound
is_a: CHEBI:3992 ! cyclic ketone

[Term]
id: CHEBI:8273
name: plumbagin
namespace: chebi_ontology
def: "A  hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively." []
subset: 3:STAR
synonym: "2-methyl-5-hydroxy-1,4-naphthoquinone" RELATED [chemidplus]
synonym: "2-methyljuglone" RELATED [chebi]
synonym: "5-hydroxy-2-methyl-1,4-naphthalenedione" RELATED [chemidplus]
synonym: "5-hydroxy-2-methyl-1,4-naphthoquinone" RELATED [chebi]
synonym: "plumbaein" RELATED [chebi]
synonym: "Plumbagin" RELATED [kegg.compound]
synonym: "plumbagine" RELATED [metacyc.compound]
synonym: "plumbagone" RELATED [chebi]
is_a: CHEBI:132157 ! hydroxy-1,4-naphthoquinone
is_a: CHEBI:33853 ! phenols
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:50249 ! has role anticoagulant
relationship: RO:0000087 CHEBI:50847 ! has role immunological adjuvant

[Term]
id: CHEBI:82891
name: glucocorticoid receptor antagonist
namespace: chebi_ontology
def: "An antagonist that binds to and deactivates glucocorticoid receptors." []
subset: 3:STAR
synonym: "glucocorticoid receptor antagonists" RELATED [chebi]
is_a: CHEBI:48706 ! antagonist

[Term]
id: CHEBI:82892
name: 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole
namespace: chebi_ontology
def: "A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group." []
subset: 3:STAR
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:24780 ! imidazoles
is_a: CHEBI:25698 ! ether

[Term]
id: CHEBI:82894
name: (R)-miconazole
namespace: chebi_ontology
def: "A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has <i>R</i> configuration." []
subset: 3:STAR
synonym: "(R)-miconazole" RELATED [uniprot_ft]
is_a: CHEBI:82892 ! 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole
relationship: RO:0018039 CHEBI:82897 ! (S)-miconazole

[Term]
id: CHEBI:82897
name: (S)-miconazole
namespace: chebi_ontology
def: "A 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole that has <i>S</i>) configuration." []
subset: 3:STAR
synonym: "(S)-miconazole" RELATED [uniprot_ft]
is_a: CHEBI:82892 ! 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole
relationship: RO:0018039 CHEBI:82894 ! (R)-miconazole

[Term]
id: CHEBI:83039
name: crustacean metabolite
namespace: chebi_ontology
def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." []
subset: 3:STAR
synonym: "crustacean metabolites" RELATED [chebi]
is_a: CHEBI:75767 ! animal metabolite

[Term]
id: CHEBI:83056
name: Daphnia magna metabolite
namespace: chebi_ontology
def: "A <em>Daphnia</em> metabolite produced by the species <em>Daphnia magna</em>." []
subset: 3:STAR
synonym: "Daphnia magna metabolites" RELATED [chebi]
is_a: CHEBI:83057 ! Daphnia metabolite

[Term]
id: CHEBI:83057
name: Daphnia metabolite
namespace: chebi_ontology
def: "A crustacean metabolite produced by the genus of small planktonic arthropods, <em>Daphnia</em>" []
subset: 3:STAR
synonym: "Daphnia metabolites" RELATED [chebi]
is_a: CHEBI:83039 ! crustacean metabolite

[Term]
id: CHEBI:83060
name: dithiocarbamate salt
namespace: chebi_ontology
def: "Any salt derived from a member of the class of dithiocarbamic acids by the formal replacement of the hydrogen of the dithiocarboxy group by a metal." []
subset: 3:STAR
synonym: "dithiocarbamate salts" RELATED [chebi]
is_a: CHEBI:24868 ! organic salt
relationship: BFO:0000051 CHEBI:84292 ! has part dithiocarbamate anions

[Term]
id: CHEBI:83072
name: EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
namespace: chebi_ontology
def: "An EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor that interferes with the action of succinate dehydrogenase (quinone), EC 1.3.5.1." []
subset: 3:STAR
synonym: "complex II inhibitor" RELATED [chebi]
synonym: "complex II inhibitors" RELATED [chebi]
synonym: "EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitors" RELATED [chebi]
synonym: "EC 1.3.5.1 inhibitor" RELATED [chebi]
synonym: "EC 1.3.5.1 inhibitors" RELATED [chebi]
synonym: "SDH inhibitor" RELATED [chebi]
synonym: "SDH inhibitors" RELATED [chebi]
synonym: "succinate dehydrogenase (ubiquinone) inhibitor" RELATED [chebi]
synonym: "succinate dehydrogenase (ubiquinone) inhibitors" RELATED [chebi]
synonym: "succinate dehydrogenase complex inhibitor" RELATED [chebi]
synonym: "succinate dehydrogenase complex inhibitors" RELATED [chebi]
synonym: "succinate dehydrogenase inhibitor" RELATED [chebi]
synonym: "succinate dehydrogenase inhibitors" RELATED [chebi]
synonym: "succinate:quinone oxidoreductase inhibitor" RELATED [chebi]
synonym: "succinate:quinone oxidoreductase inhibitors" RELATED [chebi]
synonym: "succinate:ubiquinone oxidoreductase inhibitor" RELATED [chebi]
synonym: "succinate:ubiquinone oxidoreductase inhibitors" RELATED [chebi]
synonym: "succinic dehydrogenase inhibitor" RELATED [chebi]
synonym: "succinic dehydrogenase inhibitors" RELATED [chebi]
is_a: CHEBI:77102 ! EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor

[Term]
id: CHEBI:8309
name: polymyxin B1
namespace: chebi_ontology
subset: 3:STAR
synonym: "polymycin B" RELATED [chebi]
synonym: "Polymyxin B(1)" RELATED [chebi]
synonym: "polymyxin B1" RELATED [chebi]
is_a: CHEBI:59062 ! polymyxin

[Term]
id: CHEBI:83146
name: Daphnia tenebrosa metabolite
namespace: chebi_ontology
def: "A <em>Daphnia</em> metabolite produced by the species <em>Daphnia tenebrosa</em>." []
subset: 3:STAR
synonym: "Daphnia tenebrosa metabolites" RELATED [chebi]
is_a: CHEBI:83057 ! Daphnia metabolite

[Term]
id: CHEBI:83291
name: 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine
namespace: chebi_ontology
def: "A member of the class of piperidines that is <em>N</em>-isobutylpiperidine in which a hydrogen of one of the methyl groups is replaced by a <em>p</em>-<em>tert</em>-butylphenyl group." []
subset: 3:STAR
synonym: "1-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)piperidine" RELATED [chemidplus]
is_a: CHEBI:26151 ! piperidines
is_a: CHEBI:32876 ! tertiary amine

[Term]
id: CHEBI:83293
name: (R)-fenpropidin
namespace: chebi_ontology
def: "A 1-[3-(4-<em>tert</em>-butylphenyl)-2-methylpropyl]piperidine that has <i>R</i> configuration." []
subset: 3:STAR
is_a: CHEBI:83291 ! 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine
relationship: RO:0018039 CHEBI:83294 ! (S)-fenpropidin

[Term]
id: CHEBI:83294
name: (S)-fenpropidin
namespace: chebi_ontology
def: "A 1-[3-(4-<em>tert</em>-butylphenyl)-2-methylpropyl]piperidine that has <i>S</i> configuration." []
subset: 3:STAR
is_a: CHEBI:83291 ! 1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine
relationship: RO:0018039 CHEBI:83293 ! (R)-fenpropidin

[Term]
id: CHEBI:83297
name: 4-dodecyl-2,6-dimethylmorpholine
namespace: chebi_ontology
alt_id: CHEBI:83369
def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a dodecyl group. The configuration at positions 2 and 6 is unknown or unspecified." []
subset: 3:STAR
synonym: "2,6-dimethyl-4-dodecylmorpholine" RELATED [chemidplus]
synonym: "4-dodecyl-2,6-dimethylmorpholine" RELATED [iupac]
synonym: "N-dodecyl-2,6-dimethylmorpholine" RELATED [chebi]
is_a: CHEBI:38785 ! morpholines
is_a: CHEBI:50996 ! tertiary amino compound
relationship: BFO:0000051 CHEBI:23870 ! has part dodecyl group
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:83316
name: EC 1.14.13.72 (methylsterol monooxygenase) inhibitor
namespace: chebi_ontology
def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of methylsterol monooxygenase (EC 1.14.13.72)." []
subset: 3:STAR
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitor" RELATED [chebi]
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating) inhibitors" RELATED [chebi]
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitor" RELATED [chebi]
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating) inhibitors" RELATED [chebi]
synonym: "4-methylsterol oxidase inhibitor" RELATED [chebi]
synonym: "4-methylsterol oxidase inhibitors" RELATED [chebi]
synonym: "EC 1.14.13.72 (ethylsterol monooxygenase) inhibitors" RELATED [chebi]
synonym: "EC 1.14.13.72 inhibitor" RELATED [chebi]
synonym: "EC 1.14.13.72 inhibitors" RELATED [chebi]
synonym: "methylsterol hydroxylase inhibitor" RELATED [chebi]
synonym: "methylsterol hydroxylase inhibitors" RELATED [chebi]
synonym: "methylsterol monooxygenase (EC 1.14.13.72) inhibitor" RELATED [chebi]
synonym: "methylsterol monooxygenase (EC 1.14.13.72) inhibitors" RELATED [chebi]
synonym: "methylsterol monooxygenase inhibitor" RELATED [chebi]
synonym: "methylsterol monooxygenase inhibitors" RELATED [chebi]
is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor

[Term]
id: CHEBI:83317
name: sterol biosynthesis inhibitor
namespace: chebi_ontology
def: "Any compound that inhibits the biosynthesis of any sterol." []
subset: 3:STAR
synonym: "sterol biosynthesis inhibitors" RELATED [chebi]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:83319
name: EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor
namespace: chebi_ontology
def: "An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> as acceptor) inhibitor that interferes with the action of Δ<small><sup>14</small></sup>-sterol reductase (EC 1.3.1.70)." []
subset: 3:STAR
synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitor" RELATED [chebi]
synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP(+) Delta(14)-oxidoreductase inhibitors" RELATED [chebi]
synonym: "C-14 sterol reductase inhibitor" RELATED [chebi]
synonym: "C-14 sterol reductase inhibitors" RELATED [chebi]
synonym: "Delta(14)-sterol reductase (EC 1.3.1.70) inhibitor" RELATED [chebi]
synonym: "Delta(14)-sterol reductase (EC 1.3.1.70) inhibitors" RELATED [chebi]
synonym: "Delta(14)-sterol reductase inhibitor" RELATED [chebi]
synonym: "Delta(14)-sterol reductase inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitors" RELATED [chebi]
synonym: "EC 1.3.1.70 inhibitor" RELATED [chebi]
synonym: "EC 1.3.1.70 inhibitors" RELATED [chebi]
synonym: "sterol C14-reductase inhibitor" RELATED [chebi]
synonym: "sterol C14-reductase inhibitors" RELATED [chebi]
is_a: CHEBI:76857 ! EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor

[Term]
id: CHEBI:83365
name: 2,6-dimethyl-4-tridecylmorpholine
namespace: chebi_ontology
def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a tridecyl group. The configuration at positions 2 and 6 is unknown or unspecified." []
subset: 3:STAR
synonym: "N-tridecyl-2,6-dimethylmorpholine" RELATED [chebi]
is_a: CHEBI:38785 ! morpholines
is_a: CHEBI:50996 ! tertiary amino compound
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:83368
name: 2,6-dimethyl-4-undecylmorpholine
namespace: chebi_ontology
def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by an undecyl group. The configuration at positions 2 and 6 is unknown or unspecified." []
subset: 3:STAR
synonym: "2,6-dimethyl-N-undecylmorpholine" RELATED [chebi]
is_a: CHEBI:38785 ! morpholines
is_a: CHEBI:50996 ! tertiary amino compound
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:83370
name: 2,6-dimethyl-4-tetradecylmorpholine
namespace: chebi_ontology
def: "A member of the class of morpholines that is 2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a tetradecyl group. The configuration at positions 2 and 6 is unknown or unspecified." []
subset: 3:STAR
synonym: "N-tetradecyl-2,6-dimethylmorpholine" RELATED [chebi]
is_a: CHEBI:38785 ! morpholines
is_a: CHEBI:50996 ! tertiary amino compound
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:83399
name: marine xenobiotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced by metabolism of a xenobiotic compound in marine macro- and microorganisms." []
subset: 3:STAR
synonym: "marine xenobiotic metabolites" RELATED [chebi]
is_a: CHEBI:76206 ! xenobiotic metabolite
is_a: CHEBI:76507 ! marine metabolite

[Term]
id: CHEBI:83403
name: monochlorobenzenes
namespace: chebi_ontology
def: "Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine." []
subset: 3:STAR
is_a: CHEBI:23132 ! chlorobenzenes

[Term]
id: CHEBI:83414
name: alkyl sulfate(1-)
namespace: chebi_ontology
def: "An organosulfate oxoanion obtained by deprotonation of the sulfo group of any alkyl sulfate; major species at pH 7.3." []
subset: 3:STAR
synonym: "alkyl sulfate anion" RELATED [chebi]
synonym: "an alkyl sulfate" RELATED [uniprot_ft]
is_a: CHEBI:58958 ! organosulfate oxoanion
relationship: RO:0018033 CHEBI:29281 ! alkyl sulfate

[Term]
id: CHEBI:83575
name: monofluorobenzenes
namespace: chebi_ontology
def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying a single fluorine substitutent." []
subset: 3:STAR
synonym: "monofluorobenzenes" RELATED [chebi]
is_a: CHEBI:35496 ! fluorobenzenes

[Term]
id: CHEBI:83628
name: N-acylammonia
namespace: chebi_ontology
def: "A carboxamide obtained by the formal condensation of the carboxy group of any carboxylic acid with ammonia." []
subset: 3:STAR
synonym: "a monocarboxylic acid amide" RELATED [uniprot_ft]
is_a: CHEBI:37622 ! carboxamide

[Term]
id: CHEBI:83686
name: (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol
namespace: chebi_ontology
def: "A member of the class of pyrimidines that is pyrimidin-5-ylmethanol in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 2-chlorophenyl group while the other is replaced by a 4-chlorophenyl group." []
subset: 3:STAR
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:39447 ! pyrimidines
is_a: CHEBI:83403 ! monochlorobenzenes

[Term]
id: CHEBI:83688
name: (R)-fenarimol
namespace: chebi_ontology
def: "A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has <i>R</i> configuration." []
subset: 3:STAR
is_a: CHEBI:83686 ! (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol
relationship: RO:0018039 CHEBI:83689 ! (S)-fenarimol

[Term]
id: CHEBI:83689
name: (S)-fenarimol
namespace: chebi_ontology
def: "A (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol that has <i>S</i> configuration." []
subset: 3:STAR
is_a: CHEBI:83686 ! (2-chlorophenyl)(4-chlorophenyl)pyrimidin-5-ylmethanol
relationship: RO:0018039 CHEBI:83688 ! (R)-fenarimol

[Term]
id: CHEBI:83707
name: 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
namespace: chebi_ontology
def: "A tertiary alcohol that is ethanol in which one of the hydrogens at position 1 is replaced by an <em>p</em>-fluorophenyl group, the other hydrogen at position 1 is replaced by a <em>p</em>-fluorophenyl group, and one of the hydrogens at position 2 is replaced by a 1<em>H</em>-1,2,4-triazol-1-yl group." []
subset: 3:STAR
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:35727 ! triazoles
is_a: CHEBI:83575 ! monofluorobenzenes

[Term]
id: CHEBI:83708
name: (R)-flutriafol
namespace: chebi_ontology
subset: 3:STAR
synonym: "(-)-flutriafol" RELATED [chebi]
synonym: "(R)-(-)-flutriafol" RELATED [chebi]
is_a: CHEBI:83707 ! 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
relationship: RO:0018039 CHEBI:83709 ! (S)-flutriafol

[Term]
id: CHEBI:83709
name: (S)-flutriafol
namespace: chebi_ontology
subset: 3:STAR
synonym: "(+)-flutriafol" RELATED [chebi]
synonym: "(S)-(+)-flutriafol" RELATED [chebi]
is_a: CHEBI:83707 ! 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
relationship: RO:0018039 CHEBI:83708 ! (R)-flutriafol

[Term]
id: CHEBI:83732
name: 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione
namespace: chebi_ontology
def: "A member of the class of oxazolidinones that is 5-ethenyl-5-methyl-2,4-oxazolidinedione in which the imide hydrogen is replaced by a 3,5-dichlorophenyl group." []
subset: 3:STAR
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:35356 ! dicarboximide
is_a: CHEBI:55374 ! oxazolidinone
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:83733
name: (R)-vinclozolin
namespace: chebi_ontology
def: "A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (<i>R</i>)-enantiomer of vinclozolin." []
subset: 3:STAR
is_a: CHEBI:83732 ! 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione
relationship: RO:0018039 CHEBI:83735 ! (S)-vinclozolin

[Term]
id: CHEBI:83734
name: sterol demethylation inhibitor
namespace: chebi_ontology
def: "A sterol biosynthesis inhibitor that acts by inhibiting the C14 demethylation step within fungal steroid biosynthesis." []
subset: 3:STAR
synonym: "sterol demethylation inhibitors" RELATED [chebi]
is_a: CHEBI:35718 ! antifungal agent
is_a: CHEBI:83317 ! sterol biosynthesis inhibitor

[Term]
id: CHEBI:83735
name: (S)-vinclozolin
namespace: chebi_ontology
def: "A 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione that is the (<i>S</i>)-enantiomer of vinclozolin." []
subset: 3:STAR
is_a: CHEBI:83732 ! 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione
relationship: RO:0018039 CHEBI:83733 ! (R)-vinclozolin

[Term]
id: CHEBI:83748
name: 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
namespace: chebi_ontology
def: "A tertiary alcohol that is butan-2-ol substituted by a 4-chlorophenyl group at position 2, a cyclopropyl group at position 3 and a 1<em>H</em>-1,2,4-triazol-1-yl group at position 1." []
subset: 3:STAR
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:35727 ! triazoles
is_a: CHEBI:51454 ! cyclopropanes
is_a: CHEBI:83403 ! monochlorobenzenes

[Term]
id: CHEBI:83749
name: (2R,3S)-cyproconazole
namespace: chebi_ontology
def: "The (2<i>R</i>,3<i>S</i>)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1<em>H</em>-1,2,4-triazol-1-yl)butan-2-ol." []
subset: 3:STAR
is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
relationship: RO:0018039 CHEBI:83752 ! (2S,3R)-cyproconazole

[Term]
id: CHEBI:83750
name: (2S,3S)-cyproconazole
namespace: chebi_ontology
def: "The (2<i>S</i>,3<i>S</i>)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1<em>H</em>-1,2,4-triazol-1-yl)butan-2-ol." []
subset: 3:STAR
is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
relationship: RO:0018039 CHEBI:83753 ! (2R,3R)-cyproconazole

[Term]
id: CHEBI:83752
name: (2S,3R)-cyproconazole
namespace: chebi_ontology
def: "The (2<i>S</i>,3<i>R</i>)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1<em>H</em>-1,2,4-triazol-1-yl)butan-2-ol." []
subset: 3:STAR
is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
relationship: RO:0018039 CHEBI:83749 ! (2R,3S)-cyproconazole

[Term]
id: CHEBI:83753
name: (2R,3R)-cyproconazole
namespace: chebi_ontology
def: "The (2<i>R</i>,3<i>R</i>)-stereoisomer of 2-(4-chlorophenyl)-3-cyclopropyl-1-(1<em>H</em>-1,2,4-triazol-1-yl)butan-2-ol." []
subset: 3:STAR
is_a: CHEBI:83748 ! 2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
relationship: RO:0018039 CHEBI:83750 ! (2S,3S)-cyproconazole

[Term]
id: CHEBI:83758
name: 1-\{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl\}-1H-1,2,4-triazole
namespace: chebi_ontology
def: "An  epoxide that is oxirane substituted by a 2-chlorophenyl, 4-fluorophenyl and a 1<em>H</em>-1,2,4-triazol-1-ylmethyl groups." []
subset: 3:STAR
is_a: CHEBI:32955 ! epoxide
is_a: CHEBI:35727 ! triazoles
is_a: CHEBI:83403 ! monochlorobenzenes
is_a: CHEBI:83575 ! monofluorobenzenes

[Term]
id: CHEBI:83759
name: (2S,3R)-epoxiconazole
namespace: chebi_ontology
def: "The (2<i>S</i>,3<i>R</i>)-stereoisomer of 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1<em>H</em>-1,2,4-triazole." []
subset: 3:STAR
is_a: CHEBI:83758 ! 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole
relationship: RO:0018039 CHEBI:83761 ! (2R,3S)-epoxiconazole

[Term]
id: CHEBI:83761
name: (2R,3S)-epoxiconazole
namespace: chebi_ontology
def: "The (2<i>R</i>,3<i>S</i>)-stereoisomer of 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1<em>H</em>-1,2,4-triazole." []
subset: 3:STAR
is_a: CHEBI:83758 ! 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole
relationship: RO:0018039 CHEBI:83759 ! (2S,3R)-epoxiconazole

[Term]
id: CHEBI:83779
name: 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol
namespace: chebi_ontology
def: "A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1<em>H</em>-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively." []
subset: 3:STAR
is_a: CHEBI:26878 ! tertiary alcohol
is_a: CHEBI:35727 ! triazoles
is_a: CHEBI:83403 ! monochlorobenzenes

[Term]
id: CHEBI:83780
name: (S)-tebuconazole
namespace: chebi_ontology
def: "The (<i>S</i>)-enantiomer of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1<em>H</em>-1,2,4-triazol-1-ylmethyl)pentan-3-ol." []
subset: 3:STAR
is_a: CHEBI:83779 ! 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol
relationship: RO:0018039 CHEBI:83781 ! (R)-tebuconazole

[Term]
id: CHEBI:83781
name: (R)-tebuconazole
namespace: chebi_ontology
def: "The (<i>R</i>)-enantiomer of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1<em>H</em>-1,2,4-triazol-1-ylmethyl)pentan-3-ol." []
subset: 3:STAR
is_a: CHEBI:83779 ! 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol
relationship: RO:0018039 CHEBI:83780 ! (S)-tebuconazole

[Term]
id: CHEBI:83811
name: proteinogenic amino acid derivative
namespace: chebi_ontology
def: "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." []
subset: 3:STAR
synonym: "canonical amino acid derivative" RELATED [chebi]
synonym: "canonical amino acid derivatives" RELATED [chebi]
synonym: "canonical amino-acid derivative" RELATED [chebi]
synonym: "canonical amino-acid derivatives" RELATED [chebi]
synonym: "proteinogenic amino acid derivatives" RELATED [chebi]
synonym: "proteinogenic amino-acid derivative" RELATED [chebi]
synonym: "proteinogenic amino-acid derivatives" RELATED [chebi]
is_a: CHEBI:83821 ! amino-acid derivative
relationship: RO:0018038 CHEBI:83813 ! proteinogenic amino acid

[Term]
id: CHEBI:83813
name: proteinogenic amino acid
namespace: chebi_ontology
def: "Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration." []
subset: 3:STAR
synonym: "canonical amino acid" RELATED [chebi]
synonym: "canonical amino acids" RELATED [chebi]
synonym: "proteinogenic amino acids" RELATED [chebi]
is_a: CHEBI:33709 ! amino acid

[Term]
id: CHEBI:83820
name: non-proteinogenic amino acid
namespace: chebi_ontology
def: "Any amino-acid that is not naturally encoded in the genetic code of any organism." []
subset: 3:STAR
synonym: "non-canonical amino acid" RELATED [chebi]
synonym: "non-canonical amino acids" RELATED [chebi]
synonym: "non-canonical amino-acid" RELATED [chebi]
synonym: "non-canonical amino-acids" RELATED [chebi]
synonym: "non-coded amino acid" RELATED [chebi]
synonym: "non-coded amino acids" RELATED [chebi]
synonym: "non-coded amino-acid" RELATED [chebi]
synonym: "non-coded amino-acids" RELATED [chebi]
synonym: "non-proteinogenic amino acids" RELATED [chebi]
synonym: "non-proteinogenic amino-acid" RELATED [chebi]
synonym: "non-proteinogenic amino-acids" RELATED [chebi]
is_a: CHEBI:33709 ! amino acid

[Term]
id: CHEBI:83821
name: amino-acid derivative
namespace: chebi_ontology
alt_id: CHEBI:25359
def: "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." []
subset: 3:STAR
synonym: "amino acid derivative" RELATED [chebi]
synonym: "amino acid derivatives" RELATED [chebi]
synonym: "amino-acid derivatives" RELATED [chebi]
synonym: "modified amino acids" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:83876
name: cationic sphingoid
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the amino function of any sphingoid" []
subset: 3:STAR
synonym: "cationic sphingoids" RELATED [chebi]
synonym: "sphingoid cation" RELATED [chebi]
synonym: "sphingoid cations" RELATED [chebi]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:35785 ! sphingoid

[Term]
id: CHEBI:83906
name: (S)-diniconazole
namespace: chebi_ontology
def: "A (1<i>E</i>)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the (<i>S</i>)-enantiomer of diniconazole." []
subset: 3:STAR
synonym: "(+)-diniconazole" RELATED [chebi]
synonym: "diniconazole (+)-form" RELATED [chemidplus]
synonym: "S-(+)-diniconazole" RELATED [chebi]
is_a: CHEBI:83909 ! (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol
relationship: RO:0018039 CHEBI:83911 ! diniconazole-M

[Term]
id: CHEBI:83909
name: (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol
namespace: chebi_ontology
def: "A member of the class of triazoles that is 4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol substituted at position 1 by a 2,4-dichlorophenyl group." []
subset: 3:STAR
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:35727 ! triazoles
is_a: CHEBI:78840 ! olefinic compound

[Term]
id: CHEBI:83911
name: diniconazole-M
namespace: chebi_ontology
def: "A (1<i>E</i>)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol that is the active <i>R</i>-enantiomer of diniconazole. A fungicide used to control a range of diseases including mildew, bunts and smuts." []
subset: 3:STAR
synonym: "(-)-diniconazole" RELATED [chebi]
synonym: "(E)-(R)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol" RELATED [pesticides]
synonym: "(R)-diniconazole" RELATED [chebi]
synonym: "diniconazole (-)" RELATED [chemidplus]
synonym: "R-(-)-diniconazole" RELATED [chebi]
is_a: CHEBI:83909 ! (1E)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)pent-1-en-3-ol
is_a: CHEBI:87067 ! conazole fungicide
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical
relationship: RO:0018039 CHEBI:83906 ! (S)-diniconazole

[Term]
id: CHEBI:83925
name: non-proteinogenic alpha-amino acid
namespace: chebi_ontology
def: "Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids." []
subset: 3:STAR
synonym: "non-proteinogenic alpha-amino acids" RELATED [chebi]
synonym: "non-proteinogenic alpha-amino-acid" RELATED [chebi]
synonym: "non-proteinogenic alpha-amino-acids" RELATED [chebi]
is_a: CHEBI:33704 ! alpha-amino acid
is_a: CHEBI:83820 ! non-proteinogenic amino acid

[Term]
id: CHEBI:83955
name: 2-saturated fatty acid anion
namespace: chebi_ontology
def: "A fatty acid anion obtained by deprotonation of the carboxy group of any 2-saturated fatty acid." []
subset: 3:STAR
synonym: "1,2-saturated fatty acid anion" RELATED [chebi]
synonym: "a 1,2-saturated fatty acid" RELATED [uniprot_ft]
is_a: CHEBI:28868 ! fatty acid anion

[Term]
id: CHEBI:83986
name: ethylenebis(dithiocarbamic acid)
namespace: chebi_ontology
def: "A dithiocarbamic acid resulting from the formal addition of a molecule of carbon disulfide to each amino group of ethylenediamine." []
subset: 3:STAR
synonym: "ethylenebisdithiocarbamic acid" RELATED [chemidplus]
synonym: "N,N'-(ethylene)bisdithiocarbamic acid" RELATED [chebi]
synonym: "N,N'-ethanediylbis(dithiocarbamic acid)" RELATED [chebi]
is_a: CHEBI:78787 ! dithiocarbamic acids
relationship: RO:0018034 CHEBI:77308 ! ethylenebis(dithiocarbamate)
relationship: RO:0018038 CHEBI:30347 ! ethylenediamine

[Term]
id: CHEBI:84002
name: 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one
namespace: chebi_ontology
def: "A member of the class of triazoles that is 1-hydroxy-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one in which the hydroxyl hydrogen is replaced by a 4-chlorophenyl group." []
subset: 3:STAR
is_a: CHEBI:141498 ! hemiaminal ether
is_a: CHEBI:17087 ! ketone
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:35727 ! triazoles
is_a: CHEBI:83403 ! monochlorobenzenes

[Term]
id: CHEBI:84003
name: (R)-triadimefon
namespace: chebi_ontology
def: "A 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one that is the (<i>R</i>)-enantiomer of triadimefon." []
subset: 3:STAR
is_a: CHEBI:84002 ! 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one
relationship: RO:0018039 CHEBI:84004 ! (S)-triadimefon

[Term]
id: CHEBI:84004
name: (S)-triadimefon
namespace: chebi_ontology
def: "A 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one that is the (<i>S</i>)-enantiomer of triadimefon." []
subset: 3:STAR
is_a: CHEBI:84002 ! 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one
relationship: RO:0018039 CHEBI:84003 ! (R)-triadimefon

[Term]
id: CHEBI:84055
name: pentose phosphate
namespace: chebi_ontology
def: "Any phospho sugar that is the phosphate derivative of pentose." []
subset: 3:STAR
synonym: "pentose phosphates" RELATED [chebi]
is_a: CHEBI:33447 ! phospho sugar
is_a: CHEBI:63409 ! pentose derivative

[Term]
id: CHEBI:84087
name: human urinary metabolite
namespace: chebi_ontology
def: "Any metabolite (endogenous or exogenous) found in human urine samples." []
subset: 3:STAR
synonym: "human urinary metabolites" RELATED [chebi]
is_a: CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:84186
name: L-proline derivative
namespace: chebi_ontology
def: "A proteinogenic amino acid derivative resulting from reaction of <small>L</small>-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of <small>L</small>-proline  by a heteroatom." []
subset: 3:STAR
synonym: "L-proline derivatives" RELATED [chebi]
is_a: CHEBI:26273 ! proline derivative
is_a: CHEBI:83811 ! proteinogenic amino acid derivative
relationship: RO:0018038 CHEBI:17203 ! L-proline

[Term]
id: CHEBI:84264
name: EC 3.5.1.19 (nicotinamidase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of nicotinamidase (EC 3.5.1.19)." []
subset: 3:STAR
synonym: "EC 3.5.1.19 (nicotinamidase) inhibitors" RELATED [chebi]
synonym: "EC 3.5.1.19 inhibitor" RELATED [chebi]
synonym: "EC 3.5.1.19 inhibitors" RELATED [chebi]
synonym: "nicotinamidase (EC 3.5.1.19) inhibitor" RELATED [chebi]
synonym: "nicotinamidase (EC 3.5.1.19) inhibitors" RELATED [chebi]
synonym: "nicotinamidase inhibitor" RELATED [chebi]
synonym: "nicotinamidase inhibitors" RELATED [chebi]
synonym: "nicotinamide amidase inhibitor" RELATED [chebi]
synonym: "nicotinamide amidase inhibitors" RELATED [chebi]
synonym: "nicotinamide amidohydrolase inhibitor" RELATED [chebi]
synonym: "nicotinamide amidohydrolase inhibitors" RELATED [chebi]
synonym: "nicotinamide deaminase inhibitor" RELATED [chebi]
synonym: "nicotinamide deaminase inhibitors" RELATED [chebi]
synonym: "YNDase inhibitor" RELATED [chebi]
synonym: "YNDase inhibitors" RELATED [chebi]
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:84291
name: organic sulfur anion
namespace: chebi_ontology
def: "An organic anion in which the charge resides on a sulfur atom." []
subset: 3:STAR
synonym: "organic sulfur anions" RELATED [chebi]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:84292
name: dithiocarbamate anions
namespace: chebi_ontology
def: "Any organic sulfur anion resulting from the removal of a proton from any <em>N</em>-substituted dithiocarbamic acid." []
subset: 3:STAR
is_a: CHEBI:84291 ! organic sulfur anion
relationship: RO:0018033 CHEBI:78787 ! dithiocarbamic acids

[Term]
id: CHEBI:8434
name: prochloraz
namespace: chebi_ontology
def: "A member of the class of ureas that is 1<em>H</em>-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables." []
subset: 3:STAR
is_a: CHEBI:27096 ! trichlorobenzene
is_a: CHEBI:35618 ! aromatic ether
is_a: CHEBI:47857 ! ureas
is_a: CHEBI:60600 ! amide fungicide
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87068 ! imidazole fungicide
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:84735
name: algal metabolite
namespace: chebi_ontology
def: "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." []
subset: 3:STAR
synonym: "algal metabolites" RELATED [chebi]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:84739
name: amikacin(4+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the four free amino groups of amikacin; major species at pH 7.3." []
subset: 3:STAR
synonym: "amikacin" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:2637 ! amikacin

[Term]
id: CHEBI:8489
name: propiconazole
namespace: chebi_ontology
alt_id: CHEBI:658576
def: "The cyclic ketal obtained by formal condensation of 1-(2,4-dichlorophenyl)-2-(1<em>H</em>-1,2,4-triazol-1-yl)ethanone with pentane-1,2-diol. A triazole fungicide, it is used commercially as a diastereoisomeric mixture on soft fruit (including apricots, peaches, nectarines, plums and prunes), nuts (including peanuts, pecans and almonds), mushrooms, and grasses grown for seeds." []
subset: 3:STAR
synonym: "(+-)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole" RELATED [chebi]
synonym: "Propiconazole" RELATED [kegg.compound]
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:59779 ! cyclic ketal
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:85251
name: teicoplanin A2-2
namespace: chebi_ontology
def: "A teicoplanin A<small><sub>2</sub></small> that has 8-methylnonanoyl as the variable <em>N</em>-acyl group." []
subset: 3:STAR
synonym: "34-O-(2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-(2-deoxy-2-((8-methyl-1-oxononyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chemidplus]
synonym: "34-O-[2-(acetamido)-2-deoxy-beta-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-{2-deoxy-2-[(8-methyl-1-oxononyl)amino]-beta-D-glucopyranosyl}-42-O-alpha-D-mannopyranosylristomycin A aglycone" RELATED [chebi]
synonym: "teichomycin A2 factor 2" RELATED [chemidplus]
synonym: "teicoplanin A2-2" RELATED [chemidplus]
is_a: CHEBI:34994 ! teicoplanin A2
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:86323
name: conazole antifungal agent
namespace: chebi_ontology
alt_id: CHEBI:60593
def: "A compound that has a structure that is related to miconazole, contains an azole (imidazole or triazole) moiety, and has significant systemic antifungal properties.  They inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function." []
subset: 3:STAR
synonym: "azole antibiotic" RELATED [chebi]
synonym: "azole antibiotics" RELATED [chebi]
synonym: "conazole antifungal agents" RELATED [chebi]
is_a: CHEBI:68452 ! azole
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent
relationship: RO:0000087 CHEBI:75282 ! has role ergosterol biosynthesis inhibitor

[Term]
id: CHEBI:86324
name: quinolone antibiotic
namespace: chebi_ontology
def: "An organonitrogen heterocyclic antibiotic whose structure contains a quinolone or quinolone-related skeleton." []
subset: 3:STAR
synonym: "quinolone antibiotics" RELATED [chebi]
is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic

[Term]
id: CHEBI:86327
name: antifungal drug
namespace: chebi_ontology
def: "Any antifungal agent used to prevent or treat fungal infections in humans or animals." []
subset: 3:STAR
synonym: "anti-fungal drug" RELATED [chebi]
synonym: "anti-fungal drugs" RELATED [chebi]
synonym: "anti-fungal medication" RELATED [chebi]
synonym: "anti-fungal medications" RELATED [chebi]
synonym: "antifungal drugs" RELATED [chebi]
synonym: "antifungal medication" RELATED [chebi]
synonym: "antifungal medications" RELATED [chebi]
synonym: "pharmaceutical fungicide" RELATED [chebi]
synonym: "pharmaceutical fungicides" RELATED [chebi]
is_a: CHEBI:35441 ! antiinfective agent
is_a: CHEBI:35718 ! antifungal agent

[Term]
id: CHEBI:86328
name: antifungal agrochemical
namespace: chebi_ontology
def: "Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties." []
subset: 3:STAR
synonym: "agrichemical fungicide" RELATED [chebi]
synonym: "agrichemical fungicides" RELATED [chebi]
synonym: "agrochemical fungicide" RELATED [chebi]
synonym: "agrochemical fungicides" RELATED [chebi]
synonym: "anti-fungal agrichemical" RELATED [chebi]
synonym: "anti-fungal agrichemicals" RELATED [chebi]
synonym: "anti-fungal agrochemical" RELATED [chebi]
synonym: "anti-fungal agrochemicals" RELATED [chebi]
synonym: "antifungal agrichemical" RELATED [chebi]
synonym: "antifungal agrichemicals" RELATED [chebi]
synonym: "antifungal agrochemicals" RELATED [chebi]
is_a: CHEBI:24127 ! fungicide
is_a: CHEBI:33286 ! agrochemical

[Term]
id: CHEBI:86411
name: cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine
namespace: chebi_ontology
def: "Either of the two diastereoisomers of 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1<em>H</em>-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine in which the imidazol-1-ylmethyl group and the aryloxymethyl group are in a <i>cis</i> relationship to each other - i.e. they are both on the same side of the plane of the dioxolane ring. The antifungal drug ketoconazole is a racemic mixture of the two <i>cis</i> diastereoisomers." []
subset: 3:STAR
is_a: CHEBI:48339 ! 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine

[Term]
id: CHEBI:86420
name: imidazole antifungal agent
namespace: chebi_ontology
def: "A compound that has significant antifungal properties whose structure contains an imidazole moiety." []
subset: 3:STAR
synonym: "imidazole antifungal agents" RELATED [chebi]
is_a: CHEBI:24780 ! imidazoles
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:86426
name: triazole antifungal agent
namespace: chebi_ontology
def: "A member of the class of triazole that has significant antifungal properties." []
subset: 3:STAR
synonym: "triazole antifungal agents" RELATED [chebi]
is_a: CHEBI:35727 ! triazoles
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:86478
name: antibiotic antifungal agent
namespace: chebi_ontology
def: "Heteroorganic entities that are microbial metabolites (or compounds derived from them) which have significant antifungal properties." []
subset: 3:STAR
synonym: "antibiotic antifungal agents" RELATED [chebi]
is_a: CHEBI:33285 ! heteroorganic entity
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:86482
name: strobilurin antifungal agent
namespace: chebi_ontology
def: "Any antibiotic antifungal agents whose structure is based on the antifungal agents originally isolated from the fungus <em>Strobilurus tenacellus</em>." []
subset: 3:STAR
synonym: "strobilurin antifungal agents" RELATED [chebi]
is_a: CHEBI:86478 ! antibiotic antifungal agent

[Term]
id: CHEBI:86484
name: methoxyacrylate strobilurin antifungal agent
namespace: chebi_ontology
def: "Any strobilurin antifungal agent that contains a methoxyacrylate group." []
subset: 3:STAR
synonym: "methoxyacrylate strobilurin antifungal agents" RELATED [chebi]
is_a: CHEBI:25248 ! methyl ester
is_a: CHEBI:51702 ! enoate ester
is_a: CHEBI:86482 ! strobilurin antifungal agent

[Term]
id: CHEBI:8653
name: pyocyanine
namespace: chebi_ontology
alt_id: CHEBI:137500
def: "An iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group. An antibiotic pigment produced by <em>Pseudomonas aeruginosa</em>." []
subset: 3:STAR
synonym: "pyocyanin" RELATED [chebi]
is_a: CHEBI:35285 ! iminium betaine
is_a: CHEBI:39201 ! phenazines
relationship: RO:0000087 CHEBI:26130 ! has role biological pigment
relationship: RO:0000087 CHEBI:33282 ! has role antibacterial agent
relationship: RO:0000087 CHEBI:72316 ! has role virulence factor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018033 CHEBI:62220 ! pyocyanine(1+)

[Term]
id: CHEBI:8674
name: pyrimethanil
namespace: chebi_ontology
def: "A member of the class of aminopyrimidines that is <em>N</em>-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6.  A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control <em>Botrytis cinerea</em> throughout the winemaking process in grapes, must, fermenting must and wine." []
subset: 3:STAR
synonym: "2-Anilino-4,6-dimethylpyrimidine" RELATED [hmdb]
synonym: "4,6-Dimethyl-N-phenyl-2-pyrimidinamine" RELATED [hmdb]
synonym: "N-(4,6-dimethylpyrimidin-2-yl)aniline" RELATED [pesticides]
is_a: CHEBI:38338 ! aminopyrimidine
is_a: CHEBI:50995 ! secondary amino compound
is_a: CHEBI:87208 ! anilinopyrimidine fungicide
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:72768 ! has role aryl hydrocarbon receptor agonist
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:87012
name: amide antifungal agent
namespace: chebi_ontology
def: "A compound that has significant antifungal properties whose structure contains an amide moiety." []
subset: 3:STAR
synonym: "amide antifungal agents" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:87015
name: anilide fungicide
namespace: chebi_ontology
def: "Any amide fungicide whose structure contains an anilide group." []
subset: 3:STAR
synonym: "anilide fungicides" RELATED [chebi]
is_a: CHEBI:60600 ! amide fungicide

[Term]
id: CHEBI:87034
name: aromatic fungicide
namespace: chebi_ontology
def: "An organic aromatic compound that has been used as a fungicide." []
subset: 3:STAR
synonym: "aromatic fungicides" RELATED [chebi]
is_a: CHEBI:33659 ! organic aromatic compound
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87036
name: benzimidazole fungicide
namespace: chebi_ontology
def: "Compounds that contain a benzimidazole moiety as a key feature of their structure and which have been used as fungicides." []
subset: 3:STAR
synonym: "benzimidazole fungicides" RELATED [chebi]
is_a: CHEBI:22715 ! benzimidazoles
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87037
name: benzimidazole precursor fungicide
namespace: chebi_ontology
def: "Compounds based on 1,2-phenylenediamine in which one or both of the primary amino groups have been derivatised so as to permit subsequent benzimidazole formation, and which have been used as fungicides." []
subset: 3:STAR
synonym: "benzimidazole precursor fungicides" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:24127 ! has role fungicide
relationship: RO:0018038 CHEBI:34043 ! 1,2-phenylenediamine

[Term]
id: CHEBI:87061
name: carbamate fungicide
namespace: chebi_ontology
def: "Compounds that contain a carbamate ester moiety as a key feature of their structure and which have been used as fungicides." []
subset: 3:STAR
synonym: "carbamate fungicides" RELATED [chebi]
is_a: CHEBI:23003 ! carbamate ester
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87064
name: benzimidazolylcarbamate fungicide
namespace: chebi_ontology
def: "Any carbamate fungicide that contains a benzimidazolyl group attached to the nitrogen of the carbamate moiety." []
subset: 3:STAR
synonym: "benzimidazolylcarbamate fungicides" RELATED [chebi]
is_a: CHEBI:22715 ! benzimidazoles
is_a: CHEBI:87061 ! carbamate fungicide

[Term]
id: CHEBI:87066
name: carbanilate fungicide
namespace: chebi_ontology
def: "Any carbamate fungicide that has a phenyl or substituted-phenyl group attached to the nitrogen of the carbamate group." []
subset: 3:STAR
synonym: "carbanilate fungicides" RELATED [chebi]
is_a: CHEBI:87061 ! carbamate fungicide

[Term]
id: CHEBI:87067
name: conazole fungicide
namespace: chebi_ontology
def: "Any conazole antifungal agent that has been used as a fungicide." []
subset: 3:STAR
synonym: "conazole fungicides" RELATED [chebi]
is_a: CHEBI:86323 ! conazole antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87068
name: imidazole fungicide
namespace: chebi_ontology
def: "Any imidazole antifungal agent that has been used as a fungicide." []
subset: 3:STAR
synonym: "imidazole fungicides" RELATED [chebi]
is_a: CHEBI:86420 ! imidazole antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87069
name: imidazole antifungal drug
namespace: chebi_ontology
def: "Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals." []
subset: 3:STAR
synonym: "imidazole antifungal drugs" RELATED [chebi]
is_a: CHEBI:86420 ! imidazole antifungal agent
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug

[Term]
id: CHEBI:87071
name: conazole antifungal drug
namespace: chebi_ontology
def: "Any conazole antifungal agent that has been used for the treatment of fungal infections in animals or humans." []
subset: 3:STAR
synonym: "conazole antifungal drugs" RELATED [chebi]
is_a: CHEBI:86323 ! conazole antifungal agent
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug

[Term]
id: CHEBI:87100
name: triazole fungicide
namespace: chebi_ontology
def: "Any triazole antifungal agent that has been used as a fungicide." []
subset: 3:STAR
synonym: "triazole fungicides" RELATED [chebi]
is_a: CHEBI:86426 ! triazole antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87101
name: triazole antifungal drug
namespace: chebi_ontology
def: "Any triazole antifungal agent that has been used for the treatment of fungal infections in humans or animals." []
subset: 3:STAR
synonym: "triazole antifungal drugs" RELATED [chebi]
is_a: CHEBI:86426 ! triazole antifungal agent
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug

[Term]
id: CHEBI:87113
name: antibiotic antifungal drug
namespace: chebi_ontology
def: "Any antibiotic antifungal agent used to treat fungal infections in humans or animals." []
subset: 3:STAR
synonym: "antibiotic antifungal drugs" RELATED [chebi]
is_a: CHEBI:86478 ! antibiotic antifungal agent
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug

[Term]
id: CHEBI:87114
name: antibiotic fungicide
namespace: chebi_ontology
def: "Any antibiotic antifungal agent that has been used as a fungicide." []
subset: 3:STAR
synonym: "antibiotic fungicides" RELATED [chebi]
is_a: CHEBI:86478 ! antibiotic antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87127
name: allylamine antifungal drug
namespace: chebi_ontology
def: "An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug." []
subset: 3:STAR
synonym: "allylamine antifungal drugs" RELATED [chebi]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug

[Term]
id: CHEBI:87132
name: morpholine antifungal agent
namespace: chebi_ontology
def: "A member of the class of morpholines that has significant antifungal properties." []
subset: 3:STAR
synonym: "morpholine antifungal agents" RELATED [chebi]
is_a: CHEBI:38785 ! morpholines
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:87134
name: morpholine fungicide
namespace: chebi_ontology
def: "Any morpholine antifungal agent used as a fungicide." []
subset: 3:STAR
synonym: "morpholine fungicides" RELATED [chebi]
is_a: CHEBI:87132 ! morpholine antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87185
name: florfenicol
namespace: chebi_ontology
def: "A carboxamide that is the <em>N</em>-dichloroacetyl derivative of (1<i>R</i>,2<i>S</i>)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture." []
subset: 3:STAR
synonym: "(-)-Florfenicol" RELATED [chemidplus]
synonym: "D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide" RELATED [chemidplus]
synonym: "Sch 25298" RELATED [chemidplus]
synonym: "Sch-25298" RELATED [chemidplus]
is_a: CHEBI:140325 ! secondary carboxamide
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:35850 ! sulfone
is_a: CHEBI:36683 ! organochlorine compound
is_a: CHEBI:37143 ! organofluorine compound
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent
relationship: RO:0018038 CHEBI:36386 ! dichloroacetic acid

[Term]
id: CHEBI:87195
name: dicarboximide fungicide
namespace: chebi_ontology
def: "Any dicarboximide antifungal agent used as a fungicide." []
subset: 3:STAR
synonym: "dicarboximide fungicides" RELATED [chebi]
is_a: CHEBI:87200 ! dicarboximide antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87197
name: dichlorophenyl dicarboximide fungicide
namespace: chebi_ontology
def: "A dicarboximide fungicide in which the nitrogen of the dicarboximide group is substituted by a dichlorophenyl group." []
subset: 3:STAR
synonym: "dichlorophenyl dicarboximide fungicides" RELATED [chebi]
is_a: CHEBI:23697 ! dichlorobenzene
is_a: CHEBI:87195 ! dicarboximide fungicide

[Term]
id: CHEBI:87198
name: phthalimide fungicide
namespace: chebi_ontology
def: "A dicarboximide fungicide whose structure contains a phthalimide derivative." []
subset: 3:STAR
synonym: "phthalimide fungicides" RELATED [chebi]
is_a: CHEBI:87195 ! dicarboximide fungicide

[Term]
id: CHEBI:87200
name: dicarboximide antifungal agent
namespace: chebi_ontology
def: "A compound that has significant antifungal properties whose structure contains a dicarboximide moiety." []
subset: 3:STAR
synonym: "dicarboximide antifungal agents" RELATED [chebi]
is_a: CHEBI:35356 ! dicarboximide
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:87204
name: pyrimidine antifungal agent
namespace: chebi_ontology
def: "A member of the class of pyrimidines that has significant antifungal properties." []
subset: 3:STAR
synonym: "pyrimidine antifungal agents" RELATED [chebi]
is_a: CHEBI:39447 ! pyrimidines
relationship: RO:0000087 CHEBI:35718 ! has role antifungal agent

[Term]
id: CHEBI:87205
name: pyrimidine antifungal drug
namespace: chebi_ontology
def: "Any pyrimidine antifungal agent that has been used for the treatment of fungal infections in humans or animals." []
subset: 3:STAR
synonym: "pyrimidine antifungal drugs" RELATED [chebi]
is_a: CHEBI:87204 ! pyrimidine antifungal agent
relationship: RO:0000087 CHEBI:86327 ! has role antifungal drug

[Term]
id: CHEBI:87207
name: pyrimidine fungicide
namespace: chebi_ontology
def: "Any pyrimidine antifungal agent that has been used as a fungicide." []
subset: 3:STAR
synonym: "pyrimidine fungicides" RELATED [chebi]
is_a: CHEBI:87204 ! pyrimidine antifungal agent
relationship: RO:0000087 CHEBI:24127 ! has role fungicide

[Term]
id: CHEBI:87208
name: anilinopyrimidine fungicide
namespace: chebi_ontology
def: "Any pyrimidine fungicide in which the pyrimidine ring is substituted by the nitrogen of an aniline moiety." []
subset: 3:STAR
synonym: "anilinopyrimidine fungicides" RELATED [chebi]
is_a: CHEBI:87207 ! pyrimidine fungicide

[Term]
id: CHEBI:87209
name: virginiamycin
namespace: chebi_ontology
def: "A mixture of cyclic polypeptide streptogramin antibiotics produced by <em>Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus,</em> and others. The two major components are virginiamycin M<small><sub>1</sub></small> (also known as  pristinamycin IIA) and virginiamycin S<small><sub>1</sub></small>. Virginiamycin has been widely used as a growth promotion agent in livestock and has been to have bacteriostatic activity against Gram-positive organisms such as staphylococci and streptococci." []
subset: 3:STAR
synonym: "virginiamycins" RELATED [chebi]
is_a: CHEBI:60004 ! mixture
relationship: BFO:0000051 CHEBI:46416 ! has part virginiamycin S1
relationship: BFO:0000051 CHEBI:9997 ! has part pristinamycin IIA
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:87211
name: fluoroquinolone antibiotic
namespace: chebi_ontology
def: "An organonitrogen heterocyclic antibiotic containing a quinolone (or quinolone-like) moiety and which have a fluorine atom attached to the central ring system." []
subset: 3:STAR
synonym: "fluoroquinolone antibiotics" RELATED [chebi]
is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic
is_a: CHEBI:37143 ! organofluorine compound

[Term]
id: CHEBI:87228
name: sulfonamide antibiotic
namespace: chebi_ontology
def: "A class of sulfonamides whose members generally have bacteriostatic antibiotic properties." []
subset: 3:STAR
synonym: "sulfonamide antibiotics" RELATED [chebi]
synonym: "sulfonamide antimicrobial agent" RELATED [chebi]
synonym: "sulfonamide antimicrobial agents" RELATED [chebi]
synonym: "sulphonamide antibiotic" RELATED [chebi]
synonym: "sulphonamide antibiotics" RELATED [chebi]
is_a: CHEBI:35358 ! sulfonamide
relationship: RO:0000087 CHEBI:33281 ! has role antimicrobial agent

[Term]
id: CHEBI:87230
name: nitrofuran antibiotic
namespace: chebi_ontology
def: "A member of the class of furans in which the furan ring is substituted by a nitro group and which also has significant antibiotic properties." []
subset: 3:STAR
synonym: "nitrofuran antibiotics" RELATED [chebi]
synonym: "nitrofuran antimicrobial agent" RELATED [chebi]
synonym: "nitrofuran antimicrobial agents" RELATED [chebi]
is_a: CHEBI:24129 ! furans
is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic
is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic
is_a: CHEBI:35716 ! C-nitro compound

[Term]
id: CHEBI:8733
name: Quinupristin-dalfopristin
namespace: chebi_ontology
subset: 2:STAR
synonym: "Quinupristin-dalfopristin" RELATED [kegg.compound]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:87835
name: framycetin(6+)
namespace: chebi_ontology
def: "An organic cation obtained by protonation of the  six amino groups of framycetin; major species at pH 7.3." []
subset: 3:STAR
synonym: "neomycin B" RELATED [uniprot_ft]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: RO:0018034 CHEBI:7508 ! framycetin

[Term]
id: CHEBI:88061
name: polyamine
namespace: chebi_ontology
def: "Any organic amino compound that contains two or more amino groups." []
subset: 3:STAR
synonym: "polyamines" RELATED [chebi]
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:88184
name: metal allergen
namespace: chebi_ontology
def: "Any metal which causes the onset of an allergic reaction." []
subset: 3:STAR
synonym: "allergenic metal" RELATED [chebi]
synonym: "allergenic metals" RELATED [chebi]
synonym: "metal allergens" RELATED [chebi]
is_a: CHEBI:33521 ! metal atom
relationship: RO:0000087 CHEBI:50904 ! has role allergen

[Term]
id: CHEBI:88187
name: penicillin allergen
namespace: chebi_ontology
def: "Any penicillin which causes the onset of an allergic reaction." []
subset: 3:STAR
synonym: "allergenic penicillin" RELATED [chebi]
synonym: "allergenic penicillin compound" RELATED [chebi]
synonym: "allergenic penicillin compounds" RELATED [chebi]
synonym: "allergenic penicillins" RELATED [chebi]
synonym: "penicillin allergens" RELATED [chebi]
is_a: CHEBI:17334 ! penicillin

[Term]
id: CHEBI:88188
name: drug allergen
namespace: chebi_ontology
def: "Any drug which causes the onset of an allergic reaction." []
subset: 3:STAR
synonym: "allergenic drug" RELATED [chebi]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:50904 ! allergen

[Term]
id: CHEBI:88225
name: beta-lactam antibiotic allergen
namespace: chebi_ontology
def: "Any β-lactam antibiotic which causes the onset of an allergic reaction." []
subset: 3:STAR
synonym: "allergenic beta-lactam antibiotic" RELATED [chebi]
synonym: "allergenic beta-lactam antibiotics" RELATED [chebi]
synonym: "beta-lactam antibiotic allergens" RELATED [chebi]
is_a: CHEBI:27933 ! beta-lactam antibiotic
relationship: RO:0000087 CHEBI:50904 ! has role allergen

[Term]
id: CHEBI:88227
name: potassium ionophore
namespace: chebi_ontology
def: "Any ionophore capable of transportation of potassium ions across membranes." []
subset: 3:STAR
synonym: "potassium ionophores" RELATED [chebi]
is_a: CHEBI:24869 ! ionophore

[Term]
id: CHEBI:8984
name: sodium dodecyl sulfate
namespace: chebi_ontology
def: "An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate." []
subset: 3:STAR
synonym: "SDS" RELATED [kegg.compound]
synonym: "SLS" RELATED [chemidplus]
synonym: "Sodium dodecyl sulfate" RELATED [kegg.compound]
synonym: "sodium dodecyl sulphate" RELATED [chemidplus]
synonym: "sodium dodecylsulfate" RELATED [chemidplus]
synonym: "Sodium lauryl sulfate" RELATED [kegg.compound]
synonym: "sodium lauryl sulphate" RELATED [chemidplus]
is_a: CHEBI:38700 ! organic sodium salt
relationship: BFO:0000051 CHEBI:23872 ! has part dodecyl sulfate
relationship: RO:0000087 CHEBI:27780 ! has role detergent
relationship: RO:0000087 CHEBI:50533 ! has role protein denaturant

[Term]
id: CHEBI:90710
name: receptor modulator
namespace: chebi_ontology
alt_id: CHEBI:189678
def: "A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors." []
subset: 3:STAR
synonym: "receptor modulators" RELATED [chebi]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:90799
name: dipeptide zwitterion
namespace: chebi_ontology
def: "Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3." []
subset: 3:STAR
synonym: "a dipeptide" RELATED [uniprot_ft]
is_a: CHEBI:60466 ! peptide zwitterion
relationship: RO:0018036 CHEBI:46761 ! dipeptide

[Term]
id: CHEBI:91007
name: aromatic carboxylate
namespace: chebi_ontology
def: "A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3." []
subset: 3:STAR
synonym: "an aromatic carboxylate" RELATED [uniprot_ft]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: RO:0018033 CHEBI:33859 ! aromatic carboxylic acid

[Term]
id: CHEBI:9168
name: sirolimus
namespace: chebi_ontology
alt_id: CHEBI:45276
alt_id: CHEBI:67812
def: "A macrolide lactam isolated from <em>Streptomyces hygroscopicus</em> consisting of a 29-membered ring containing 4 <i>trans</i> double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent." []
subset: 3:STAR
synonym: "(-)-Rapamycin" RELATED [chemidplus]
synonym: "(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone" RELATED [iupac]
synonym: "Antibiotic AY 22989" RELATED [drugbank]
synonym: "rapamycin" RELATED [chebi]
synonym: "Sirolimus" RELATED [kegg.compound]
is_a: CHEBI:145565 ! macrolide lactam
is_a: CHEBI:25698 ! ether
is_a: CHEBI:26979 ! organic heterotricyclic compound
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:59770 ! cyclic acetal
is_a: CHEBI:87113 ! antibiotic antifungal drug
relationship: RO:0000087 CHEBI:149553 ! has role anticoronaviral agent
relationship: RO:0000087 CHEBI:176497 ! has role geroprotector
relationship: RO:0000087 CHEBI:35610 ! has role antineoplastic agent
relationship: RO:0000087 CHEBI:35705 ! has role immunosuppressive agent
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:68481 ! has role mTOR inhibitor
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite

[Term]
id: CHEBI:9212
name: sparfloxacin
namespace: chebi_ontology
subset: 3:STAR
synonym: "cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid" RELATED [kegg.compound]
synonym: "Sparfloxacin" RELATED [kegg.compound]
is_a: CHEBI:23765 ! quinolone
is_a: CHEBI:26512 ! quinolinemonocarboxylic acid
is_a: CHEBI:46848 ! N-arylpiperazine
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic

[Term]
id: CHEBI:9215
name: spectinomycin
namespace: chebi_ontology
alt_id: CHEBI:45551
def: "A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium <em>Streptomyces spectabilis</em>." []
subset: 3:STAR
synonym: "Antibiotic 2233wp" RELATED [chemidplus]
is_a: CHEBI:146295 ! pyranobenzodioxin
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:50995 ! secondary amino compound
is_a: CHEBI:59770 ! cyclic acetal
is_a: CHEBI:59780 ! cyclic hemiketal
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
relationship: RO:0018033 CHEBI:146260 ! spectinomycin(1+)
relationship: RO:0018033 CHEBI:77315 ! spectinomycin(2+)

[Term]
id: CHEBI:9242
name: spiroxamine
namespace: chebi_ontology
alt_id: CHEBI:546779
def: "The spiroketal resulting from the formal condensation of 4-<em>tert</em>-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powdery mildew in the production of cereals, bananas and grapes." []
subset: 3:STAR
synonym: "(8-tert-Butyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-ethyl-propyl-amine" RELATED [chembl]
synonym: "8-(1,1-dimethylethyl)-N-ethyl-N-propyl-1,4-dioxaspiro(4.5)decane-2-methanamine" RELATED [chebi]
synonym: "KWG4168" RELATED [kegg.compound]
synonym: "Spiroxamine" RELATED [kegg.compound]
is_a: CHEBI:39430 ! dioxolane
is_a: CHEBI:50996 ! tertiary amino compound
is_a: CHEBI:72600 ! spiroketal
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:9321
name: sulbactam
namespace: chebi_ontology
subset: 3:STAR
synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide" RELATED [chemidplus]
synonym: "(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide" RELATED [iupac]
synonym: "CP 45899" RELATED [drugbank]
synonym: "CP-45899" RELATED [drugbank]
synonym: "CP45899" RELATED [drugbank]
synonym: "penicillanic acid 1,1-dioxide" RELATED [chebi]
synonym: "penicillanic acid sulfone" RELATED [chebi]
is_a: CHEBI:25865 ! penicillanic acids
relationship: RO:0018034 CHEBI:229543 ! sulbactam(1-)

[Term]
id: CHEBI:9448
name: terbinafine
namespace: chebi_ontology
def: "A tertiary amine that is <em>N</em>-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(<em>tert</em>butylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections." []
subset: 3:STAR
synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine" RELATED [chemidplus]
synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine" RELATED [chemidplus]
synonym: "terbinafine" RELATED [who_mednet]
is_a: CHEBI:25477 ! naphthalenes
is_a: CHEBI:32876 ! tertiary amine
is_a: CHEBI:59831 ! enyne
is_a: CHEBI:87127 ! allylamine antifungal drug
relationship: RO:0000087 CHEBI:50183 ! has role P450 inhibitor
relationship: RO:0000087 CHEBI:59285 ! has role EC 1.14.13.132 (squalene monooxygenase) inhibitor
relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor
relationship: RO:0018033 CHEBI:77615 ! terbinafine(1+)

[Term]
id: CHEBI:94759
name: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
namespace: chebi_ontology
subset: 2:STAR
synonym: "fasinex" RELATED [drugcentral]
is_a: CHEBI:35618 ! aromatic ether

[Term]
id: CHEBI:9587
name: ticarcillin
namespace: chebi_ontology
def: "A penicillin compound having a 6β-[(2<i>R</i>)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group." []
subset: 3:STAR
synonym: "(2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" RELATED [iupac]
synonym: "alpha-carboxy-3-thienylmethylpenicillin" RELATED [patent]
is_a: CHEBI:88187 ! penicillin allergen
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0018034 CHEBI:51811 ! ticarcillin(2-)

[Term]
id: CHEBI:9665
name: triadimefon
namespace: chebi_ontology
def: "A racemate comprising equal amounts of (<i>R</i>)- and (<i>S</i>)-triadimefon. A fungicide used to control powdery mildew, rusts and other infections in crops." []
subset: 3:STAR
synonym: "(+-)-triadimefon" RELATED [chebi]
synonym: "(RS)-triadimefon" RELATED [chebi]
synonym: "1-(1,2,4-Triazoyl-1)-1-(4-chloro-phenoxy)-3,3-dimethylbutanone" RELATED [chemidplus]
synonym: "1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one" RELATED [chemidplus]
synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butanone" RELATED [nist]
synonym: "1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone" RELATED [pesticides]
synonym: "rac-triadimefon" RELATED [chebi]
synonym: "racemic triadimefon" RELATED [chebi]
synonym: "triadimefone" RELATED [metacyc.compound]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87067 ! conazole fungicide
is_a: CHEBI:87100 ! triazole fungicide
relationship: BFO:0000051 CHEBI:84003 ! has part (R)-triadimefon
relationship: BFO:0000051 CHEBI:84004 ! has part (S)-triadimefon
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:77884 ! has role EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:9700
name: tridemorph
namespace: chebi_ontology
def: "A mixture of 4-alkyl-2,6-dimethylmorpholines, where 'alkyl' is a mixture of C<small><sub>11</sub></small> to C<small><sub>14</sub></small> homologues of which 60-70% is tridecyl. A systemic fungicide, it is no longer approved for use within the European Union." []
subset: 3:STAR
synonym: "BAS 2203F" RELATED [chemidplus]
synonym: "Tridemorph" RELATED [kegg.compound]
synonym: "tridemorphe" RELATED [chebi]
is_a: CHEBI:60004 ! mixture
is_a: CHEBI:87134 ! morpholine fungicide
relationship: BFO:0000051 CHEBI:83297 ! has part 4-dodecyl-2,6-dimethylmorpholine
relationship: BFO:0000051 CHEBI:83365 ! has part 2,6-dimethyl-4-tridecylmorpholine
relationship: BFO:0000051 CHEBI:83368 ! has part 2,6-dimethyl-4-undecylmorpholine
relationship: BFO:0000051 CHEBI:83370 ! has part 2,6-dimethyl-4-tetradecylmorpholine
relationship: RO:0000087 CHEBI:83317 ! has role sterol biosynthesis inhibitor
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:9763
name: trovafloxacin
namespace: chebi_ontology
def: "A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and  6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure." []
subset: 3:STAR
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:33709 ! amino acid
is_a: CHEBI:38295 ! azabicycloalkane
is_a: CHEBI:38582 ! difluorobenzene
is_a: CHEBI:50994 ! primary amino compound
is_a: CHEBI:50996 ! tertiary amino compound
is_a: CHEBI:73537 ! 1,8-naphthyridine derivative
is_a: CHEBI:86324 ! quinolone antibiotic
is_a: CHEBI:87211 ! fluoroquinolone antibiotic
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug
relationship: RO:0000087 CHEBI:50908 ! has role hepatotoxic agent
relationship: RO:0000087 CHEBI:53559 ! has role topoisomerase IV inhibitor
relationship: RO:0000087 CHEBI:59517 ! has role DNA synthesis inhibitor
relationship: RO:0018033 CHEBI:77569 ! trovafloxacin(1+)

[Term]
id: CHEBI:9948
name: verapamil
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of dexverapamil and (<i>S</i>)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine." []
subset: 3:STAR
synonym: "Verapamil" RELATED [kegg.compound]
is_a: CHEBI:60911 ! racemate
relationship: BFO:0000051 CHEBI:77734 ! has part dexverapamil
relationship: BFO:0000051 CHEBI:77736 ! has part (S)-verapamil
relationship: RO:0000087 CHEBI:35620 ! has role vasodilator agent
relationship: RO:0000087 CHEBI:35674 ! has role antihypertensive agent
relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
relationship: RO:0000087 CHEBI:38070 ! has role anti-arrhythmia drug
relationship: RO:0000087 CHEBI:38215 ! has role calcium channel blocker
relationship: RO:0000087 CHEBI:62872 ! has role EC 1.2.3.1 (aldehyde oxidase) inhibitor
relationship: RO:0000087 CHEBI:77255 ! has role EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor
relationship: RO:0000087 CHEBI:77745 ! has role EC 3.4.24.18 (meprin A) inhibitor
relationship: RO:0000087 CHEBI:77747 ! has role EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor
relationship: RO:0000087 CHEBI:77748 ! has role EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant

[Term]
id: CHEBI:9986
name: vinclozolin
namespace: chebi_ontology
def: "A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-vinclozolin.  A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control <em>Botrytis</em>, <em>Sclerotinia</em> and <em>Monilia</em> spp." []
subset: 3:STAR
synonym: "(+-)-vinclozolin" RELATED [chebi]
synonym: "(RS)-vinclozolin" RELATED [chebi]
synonym: "3-(3,5-Dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione" RELATED [chemidplus]
synonym: "3-(3,5-Dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione" RELATED [chemidplus]
synonym: "N-3,5-Dichlorophenyl-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione" RELATED [nist]
synonym: "rac-vinclozolin" RELATED [chebi]
synonym: "racemic vinclozolin" RELATED [chebi]
synonym: "Vinchlozoline" RELATED [chemidplus]
synonym: "Vinclozoline" RELATED [chemidplus]
is_a: CHEBI:60911 ! racemate
is_a: CHEBI:87197 ! dichlorophenyl dicarboximide fungicide
relationship: BFO:0000051 CHEBI:83733 ! has part (R)-vinclozolin
relationship: BFO:0000051 CHEBI:83735 ! has part (S)-vinclozolin
relationship: RO:0000087 CHEBI:35497 ! has role androgen antagonist
relationship: RO:0000087 CHEBI:86328 ! has role antifungal agrochemical

[Term]
id: CHEBI:9997
name: pristinamycin IIA
namespace: chebi_ontology
alt_id: CHEBI:46395
def: "A macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by <em>Streptomyces pristinaespiralis</em>. Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin-resistant <em>Staphylococcus aureus</em>." []
subset: 3:STAR
synonym: "Mikamycin A" RELATED [kegg.compound]
synonym: "Ostreogrycin a" RELATED [chemidplus]
synonym: "Streptogramin A" RELATED [kegg.compound]
synonym: "Virginiamycin factor M1" RELATED [chemidplus]
synonym: "Virginiamycin M1" RELATED [kegg.compound]
is_a: CHEBI:140325 ! secondary carboxamide
is_a: CHEBI:140326 ! tertiary carboxamide
is_a: CHEBI:23763 ! pyrroline
is_a: CHEBI:24995 ! lactam
is_a: CHEBI:25105 ! macrolide antibiotic
is_a: CHEBI:35681 ! secondary alcohol
is_a: CHEBI:3992 ! cyclic ketone
is_a: CHEBI:46812 ! 1,3-oxazoles
is_a: CHEBI:51751 ! enamide
relationship: RO:0000087 CHEBI:131604 ! has role Mycoplasma genitalium metabolite
relationship: RO:0000087 CHEBI:36047 ! has role antibacterial drug

[Term]
id: CL:0000000
name: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
subset: ubprop:upper_level
xref: CALOHA:TS-2035
xref: FMA:68646
xref: GO:0005623
xref: KUPO:0000002
xref: MESH:D002477
xref: VHOG:0001533
xref: WBbt:0004017
xref: XAO:0003012
is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
disjoint_from: GO:0031012 ! extracellular matrix
disjoint_from: GO:0032991 ! protein-containing complex
disjoint_from: GO:0043226 ! organelle
disjoint_from: GO:0044423 ! virion component
relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus
relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus
relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms

[Term]
id: CL:0000005
name: neural crest derived fibroblast
def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432]
subset: human_subset
subset: mouse_subset
synonym: "fibroblast neural crest derived" EXACT []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell

[Term]
id: CL:0000006
name: neuronal receptor cell
def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception

[Term]
id: CL:0000007
name: early embryonic cell (metazoa)
def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0002321 ! embryonic cell (metazoa)

[Term]
id: CL:0000008
name: migratory cranial neural crest cell
def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091]
subset: human_subset
subset: mouse_subset
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000011
name: migratory trunk neural crest cell
def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095]
subset: human_subset
subset: mouse_subset
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000014
name: germ line stem cell
def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016]
subset: human_subset
subset: mouse_subset
synonym: "germline stem cell" EXACT []
is_a: CL:0000034 ! stem cell
is_a: CL:0000039 ! germ line cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division

[Term]
id: CL:0000021
name: female germ cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: MA:0000388
xref: ncithesaurus:Egg
xref: VHOG:0001530
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis
relationship: RO:0002215 GO:0048477 ! capable of oogenesis

[Term]
id: CL:0000022
name: female germ line stem cell
def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016]
subset: human_subset
subset: mouse_subset
is_a: CL:0000014 ! germ line stem cell
is_a: CL:0000021 ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division

[Term]
id: CL:0000023
name: oocyte
def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "oogonium" RELATED []
xref: BTO:0000964
xref: CALOHA:TS-0711
xref: FMA:18644
xref: MESH:D009865
xref: WBbt:0006797
is_a: CL:0000021 ! female germ cell
relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division

[Term]
id: CL:0000024
name: oogonial cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:83673
is_a: CL:0000021 ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: RO:0002215 GO:0000278 ! capable of mitotic cell cycle
relationship: RO:0002202 CL:0000670 ! develops from primordial germ cell
relationship: RO:0002215 GO:0000278 ! capable of mitotic cell cycle

[Term]
id: CL:0000025
name: egg cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544]
subset: human_subset
subset: mouse_subset
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
xref: BTO:0000369
xref: BTO:0003801
xref: CALOHA:TS-2191
xref: FMA:67343
xref: MESH:D010063
is_a: CL:0000675 ! female gamete
relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division
relationship: RO:0002202 CL:0000023 ! develops from oocyte

[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432]
subset: human_subset
subset: mouse_subset
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell

[Term]
id: CL:0000029
name: neural crest derived neuron
def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neuron neural crest derived" EXACT []
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
relationship: RO:0002202 CL:0002676 ! develops from neural crest derived neuroblast

[Term]
id: CL:0000030
name: glioblast
def: "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes." [PMID:37824650, Wikipedia:Glioblast]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell

[Term]
id: CL:0000031
name: neuroblast (sensu Vertebrata)
def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neuroblast" EXACT []
xref: BTO:0000930
xref: FMA:70563
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>

[Term]
id: CL:0000034
name: stem cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234]
comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "animal stem cell" EXACT []
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
relationship: RO:0002215 GO:0017145 ! capable of stem cell division

[Term]
id: CL:0000035
name: single fate stem cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
xref: FMA:70569
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001400 ! bearer of unipotent
intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division
relationship: RO:0000053 PATO:0001400 ! bearer of unipotent

[Term]
id: CL:0000036
name: epithelial fate stem cell
def: "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues." [doi:/10.1038/sj.eye.6700575, PMID:17289566]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "epithelial stem cell" EXACT []
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: RO:0002215 GO:0030855 ! capable of epithelial cell differentiation
relationship: RO:0002215 GO:0030855 ! capable of epithelial cell differentiation

[Term]
id: CL:0000037
name: hematopoietic stem cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770]
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:86475
xref: MESH:D006412
xref: VHOG:0001485
is_a: CL:0000723 ! somatic stem cell
is_a: CL:0008001 ! hematopoietic precursor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation
intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: RO:0002202 CL:0000566 ! develops from angioblastic mesenchymal cell
relationship: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation

[Term]
id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000039
name: germ line cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children.
subset: general_cell_types_upper_slim
subset: human_subset
subset: mouse_subset
subset: ubprop:upper_level
is_a: CL:0000000 ! cell
relationship: RO:0002215 GO:0022414 ! capable of reproductive process

[Term]
id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
subset: human_subset
subset: mouse_subset
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin
intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation
relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
relationship: BFO:0000051 GO:0000791 ! has part euchromatin
relationship: BFO:0000051 GO:0005730 ! has part nucleolus
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002202 CL:0002009 ! develops from macrophage dendritic cell progenitor

[Term]
id: CL:0000047
name: neural stem cell
def: "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types." [PMID:30639325]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neuronal stem cell" EXACT [PMID:16305818]
synonym: "NSC" EXACT []
xref: BTO:0002881
xref: CALOHA:TS-2360
xref: FMA:86684
is_a: CL:0002319 ! neural cell
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell

[Term]
id: CL:0000048
name: multi fate stem cell
def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add]
subset: human_subset
subset: mouse_subset
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
xref: FMA:84789
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001402 ! bearer of multipotent
intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division
relationship: RO:0000053 PATO:0001402 ! bearer of multipotent

[Term]
id: CL:0000049
name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor.  For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
xref: BTO:0004730
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell
disjoint_from: CL:0000051 ! common lymphoid progenitor
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell

[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566]
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation
intersection_of: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation
disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell
disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor
relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation
relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation

[Term]
id: CL:0000051
name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation
relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation

[Term]
id: CL:0000052
name: totipotent stem cell
def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "totipotential stem cell" EXACT []
xref: FMA:84790
xref: MESH:D039901
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000056
name: myoblast
def: "A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0000222
xref: CALOHA:TS-0650
xref: FMA:70335
xref: VHOG:0001529
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000057
name: fibroblast
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347]
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0000452
xref: CALOHA:TS-0362
xref: FMA:63877
xref: NCIT:C12482
xref: VHOG:0001482
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000058
name: chondroblast
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
is_a: CL:0002320 ! connective tissue cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0007009 ! develops from prechondroblast
relationship: RO:0003000 UBERON:0002418 ! produces cartilage tissue

[Term]
id: CL:0000064
name: ciliated cell
def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: VHOG:0001532
xref: XAO:0000031
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000051 GO:0005929 ! has part cilium
relationship: BFO:0000051 GO:0005929 ! has part cilium

[Term]
id: CL:0000065
name: ependymal cell
def: "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile." [doi:/10.3389/fncel.2021.703951, GOC:tfm, https://www.britannica.com/science/ependymal-cell, JB:jb, PMID:34335193, PMID:37008045, PMID:9550134]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "ependymocyte" NARROW [doi:10.53347/rID-51713]
xref: BTO:0001724
xref: FMA:70550
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0000125 ! glial cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004670 ! part of ependyma
relationship: BFO:0000050 UBERON:0004670 ! part of ependyma
relationship: RO:0002207 CL:0000681 ! directly develops from radial glial cell

[Term]
id: CL:0000066
name: epithelial cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "epitheliocyte" EXACT []
xref: BTO:0000414
xref: CALOHA:TS-2026
xref: CARO:0000077
xref: FMA:66768
xref: WBbt:0003672
is_a: CL:0000255 ! eukaryotic cell
disjoint_from: CL:0000738 ! leukocyte
relationship: BFO:0000050 UBERON:0000483 ! part of epithelium

[Term]
id: CL:0000067
name: ciliated epithelial cell
def: "An epithelial cell that has a cilia." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:70605
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000051 GO:0005929 ! has part cilium

[Term]
id: CL:0000068
name: duct epithelial cell
def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000058 ! part of duct
relationship: BFO:0000050 UBERON:0000058 ! part of duct

[Term]
id: CL:0000069
name: branched duct epithelial cell
subset: human_subset
subset: mouse_subset
is_a: CL:0000068 ! duct epithelial cell

[Term]
id: CL:0000071
name: blood vessel endothelial cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel
relationship: BFO:0000050 UBERON:0004638 ! part of blood vessel endothelium

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000076
name: squamous epithelial cell
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: CALOHA:TS-1249
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000077
name: mesothelial cell
def: "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." [GOC:tfm, ISBN:0721662544, PMID:26106328]
comment: Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. {xref="PMID:26106328"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "mesotheliocyte" EXACT []
xref: FMA:66773
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
relationship: BFO:0000050 UBERON:0001136 ! part of mesothelium

[Term]
id: CL:0000078
name: peridermal cell
def: "Any squamous epithelial cell that is part of some periderm." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000362 ! epidermal cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0003055 ! part of periderm
relationship: BFO:0000050 UBERON:0003055 ! part of periderm

[Term]
id: CL:0000080
name: circulating cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid
relationship: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid

[Term]
id: CL:0000081
name: blood cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:62844
xref: MESH:D001773
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation
relationship: RO:0002215 GO:0008015 ! capable of blood circulation

[Term]
id: CL:0000082
name: epithelial cell of lung
def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium
relationship: BFO:0000050 UBERON:0000115 ! part of lung epithelium

[Term]
id: CL:0000084
name: T cell
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
xref: BTO:0000782
xref: CALOHA:TS-1001
xref: FMA:62870
xref: MESH:D013601
xref: VHOG:0001479
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: RO:0002215 GO:0002456 ! capable of T cell mediated immunity
relationship: RO:0002202 CL:0000827 ! develops from pro-T cell
relationship: RO:0002215 GO:0002456 ! capable of T cell mediated immunity

[Term]
id: CL:0000092
name: osteoclast
def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158]
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "chondroclast" RELATED []
xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
xref: MESH:D010010
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element
intersection_of: BFO:0000051 PR:000001850 ! has part cathepsin K
intersection_of: BFO:0000051 PR:000001937 ! has part tartrate-resistant acid phosphatase type 5
intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
intersection_of: BFO:0000051 PR:000007597 ! has part protein c-Fos
intersection_of: BFO:0000051 PR:000011178 ! has part nuclear factor NF-kappa-B p100 subunit
intersection_of: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
intersection_of: RO:0002215 GO:0045453 ! capable of bone resorption
relationship: BFO:0000051 PR:000001850 ! has part cathepsin K
relationship: BFO:0000051 PR:000001937 ! has part tartrate-resistant acid phosphatase type 5
relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
relationship: BFO:0000051 PR:000007597 ! has part protein c-Fos
relationship: BFO:0000051 PR:000011178 ! has part nuclear factor NF-kappa-B p100 subunit
relationship: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0002202 CL:0000576 ! develops from monocyte
relationship: RO:0002215 GO:0045453 ! capable of bone resorption

[Term]
id: CL:0000094
name: granulocyte
def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "granular leucocyte" EXACT []
synonym: "granular leukocyte" EXACT []
synonym: "polymorphonuclear leukocyte" EXACT []
xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000051 GO:0030141 ! has part secretory granule
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8
intersection_of: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor
intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation
relationship: BFO:0000051 GO:0030141 ! has part secretory granule
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001332 ! has plasma membrane part cell adhesion molecule CEACAM8
relationship: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasminogen activator surface receptor

[Term]
id: CL:0000095
name: neuron associated cell
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0002319 ! neural cell
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell

[Term]
id: CL:0000098
name: sensory epithelial cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
subset: human_subset
subset: mouse_subset
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception

[Term]
id: CL:0000099
name: interneuron
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "CNS interneuron" RELATED []
xref: BTO:0003811
xref: FMA:67313
xref: WBbt:0005113
is_a: CL:2000029 ! central nervous system neuron
relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system

[Term]
id: CL:0000100
name: motor neuron
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "motoneuron" EXACT []
xref: BTO:0000312
xref: FMA:83617
xref: WBbt:0005409
is_a: CL:0000527 ! efferent neuron

[Term]
id: CL:0000101
name: sensory neuron
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0001037
xref: FMA:84649
xref: MESH:D011984
xref: WBbt:0005759
is_a: CL:0000526 ! afferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception
relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception

[Term]
id: CL:0000107
name: autonomic neuron
def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:80121
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system
relationship: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system

[Term]
id: CL:0000108
name: cholinergic neuron
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0004902
xref: FMA:84796
xref: MESH:D059329
xref: WBbt:0006840
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission
relationship: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission

[Term]
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0001433
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate

[Term]
id: CL:0000114
name: surface ectodermal cell
def: "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024)." [doi:/10.1101/2024.07.02.601324, PMID:7892198, Wikipedia:Surface_ectoderm]
subset: human_subset
subset: mouse_subset
synonym: "cell of surface ectoderm" EXACT []
synonym: "surface ectoderm cell" EXACT [doi:/10.1101/2024.07.02.601324]
xref: FMA:72552
is_a: CL:0000221 ! ectodermal cell
intersection_of: CL:0000221 ! ectodermal cell
intersection_of: BFO:0000050 UBERON:0000076 ! part of external ectoderm
relationship: BFO:0000050 UBERON:0000076 ! part of external ectoderm

[Term]
id: CL:0000115
name: endothelial cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341]
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "endotheliocyte" EXACT []
xref: BTO:0001176
xref: CALOHA:TS-0278
xref: FMA:66772
is_a: CL:0000255 ! eukaryotic cell
relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell

[Term]
id: CL:0000118
name: basket cell
def: "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." [WikipediaVersioned:Basket_cell&oldid=951703880]
subset: BDS_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0000053 PATO:0070002 ! bearer of basket cell morphology
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
relationship: RO:0000053 PATO:0070002 ! bearer of basket cell morphology

[Term]
id: CL:0000119
name: cerebellar Golgi cell
def: "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004." [NIFSTD:sao1415726815]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cerebellar Golgi neuron" EXACT []
synonym: "cerebellum Golgi cell" EXACT []
synonym: "Golgi cell" EXACT []
synonym: "Golgi neuron" EXACT []
xref: MESH:D000080906
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
relationship: RO:0002100 UBERON:0002956 ! has soma location granular layer of cerebellar cortex
relationship: RO:0002113 UBERON:0002956 ! has presynaptic terminal in granular layer of cerebellar cortex
relationship: RO:0002360 UBERON:0002974 ! has dendrite location molecular layer of cerebellar cortex

[Term]
id: CL:0000120
name: granule cell
def: "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb." [https://medical-dictionary.thefreedictionary.com/granule+cell]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0003393
is_a: CL:2000029 ! central nervous system neuron

[Term]
id: CL:0000121
name: Purkinje cell
def: "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress." [MESH:D011689, PMID:12907269, PMID:14568361, PMID:31424738, PMID:33288911, PMID:38168772]
comment: Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024). {xref="PMID:27215193", xref="PMID:17535929", xref="PMID:37426070", xref="https://doi.org/10.1016/j.stem.2023.11.013"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cerebellar Purkinje cell" EXACT [https://doi.org/10.1016/j.proghi.2004.07.002]
synonym: "Purkinje neuron" EXACT [PMID:28821816]
xref: BTO:0001011
xref: CALOHA:TS-0845
xref: FMA:67969
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:1001611 ! cerebellar neuron
relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex

[Term]
id: CL:0000122
name: stellate neuron
def: "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." [ISBN:9780123973481]
subset: BDS_subset
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0002316
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0000053 PATO:0070010 ! bearer of stellate morphology
relationship: RO:0000053 PATO:0070010 ! bearer of stellate morphology

[Term]
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000095 ! neuron associated cell
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>

[Term]
id: CL:0000125
name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
xref: CALOHA:TS-0415
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell

[Term]
id: CL:0000126
name: macroglial cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "macrogliocyte" EXACT []
xref: BTO:0000771
xref: CALOHA:TS-2027
xref: FMA:54538
is_a: CL:0000125 ! glial cell
relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata)

[Term]
id: CL:0000127
name: astrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978]
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "astrocytic glia" EXACT []
xref: BTO:0000099
xref: CALOHA:TS-0060
xref: FMA:54537
is_a: CL:0000126 ! macroglial cell

[Term]
id: CL:0000128
name: oligodendrocyte
def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:D009836]
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "oligodendroglia" RELATED []
synonym: "OLs" EXACT [PMID:8734446]
xref: BTO:0000962
xref: CALOHA:TS-0709
xref: FMA:54540
is_a: CL:0000126 ! macroglial cell
is_a: CL:4023154 ! myelinating glial cell
relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system
relationship: RO:0002202 CL:0002453 ! develops from oligodendrocyte precursor cell

[Term]
id: CL:0000129
name: microglial cell
def: "A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275]
comment: Unlike macroglial cells, microglial cells  arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. {xref="PMID:23616747"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "brain macrophage" BROAD []
synonym: "brain-resident macrophage" EXACT []
synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/]
synonym: "MF.microglia.CNS" RELATED []
synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/]
xref: BTO:0000078
xref: BTO:0000962
xref: FMA:54539
is_a: CL:0000125 ! glial cell
is_a: CL:0000878 ! central nervous system macrophage
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin
intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin
relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell
relationship: RO:0002215 GO:0045087 ! capable of innate immune response

[Term]
id: CL:0000131
name: gut endothelial cell
def: "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream." [PMID:26564856]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract
relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract
relationship: RO:0002202 CL:0000223 ! develops from endodermal cell

[Term]
id: CL:0000133
name: neurectodermal cell
def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "bone marrow stromal cells" NARROW []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
xref: BTO:0002625
xref: BTO:0003298
xref: FMA:70546
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002320 ! connective tissue cell

[Term]
id: CL:0000136
name: adipocyte
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "adipose cell" EXACT []
synonym: "fat cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell

[Term]
id: CL:0000138
name: chondrocyte
def: "A skeletogenic cell that secretes a specialized, avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902, PMID:32491508]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cartilage cell" EXACT []
xref: BTO:0000249
xref: CALOHA:TS-0138
xref: FMA:66782
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000667 ! collagen secreting cell
is_a: CL:0007001 ! skeletogenic cell
relationship: RO:0001025 UBERON:0002418 ! located in cartilage tissue
relationship: RO:0002202 CL:0000058 ! develops from chondroblast

[Term]
id: CL:0000145
name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: CL:0000147
name: pigment cell
def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
xref: VHOG:0001678
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000149
name: visual pigment cell
subset: human_subset
subset: mouse_subset
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000150
name: glandular secretory epithelial cell
def: "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." [GOC:tfm, ORCID:0000-0002-7073-9172]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "glandular epithelial cell" EXACT []
xref: CALOHA:TS-2085
xref: FMA:86494
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002530 ! part of gland
relationship: BFO:0000050 UBERON:0002530 ! part of gland

[Term]
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell
relationship: RO:0002215 GO:0032940 ! capable of secretion by cell

[Term]
id: CL:0000152
name: exocrine cell
def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:16014
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland
relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland

[Term]
id: CL:0000153
name: glycosaminoglycan secreting cell
def: "A cell that secretes glycosaminoglycans." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "GAG secreting cell" EXACT []
synonym: "hyaluronic acid secreting cell" NARROW []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell

[Term]
id: CL:0000154
name: protein secreting cell
def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0009306 ! capable of protein secretion
relationship: RO:0002215 GO:0009306 ! capable of protein secretion

[Term]
id: CL:0000159
name: seromucus secreting cell
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000163
name: endocrine cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "endocrinocyte" EXACT []
xref: FMA:83809
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system

[Term]
id: CL:0000165
name: neuroendocrine cell
def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099]
comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "neurosecretory cell" RELATED []
synonym: "neurosecretory neuron" RELATED []
xref: BTO:0002691
xref: FMA:83810
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000527 ! efferent neuron
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0046879 ! capable of hormone secretion

[Term]
id: CL:0000166
name: chromaffin cell
def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:D019439]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "phaeochromocyte" EXACT []
xref: BTO:0000259
xref: FMA:69263
is_a: CL:0000029 ! neural crest derived neuron
is_a: CL:0000568 ! amine precursor uptake and decarboxylation cell

[Term]
id: CL:0000167
name: peptide hormone secreting cell
def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0030072 ! capable of peptide hormone secretion
relationship: RO:0002215 GO:0030072 ! capable of peptide hormone secretion

[Term]
id: CL:0000174
name: steroid hormone secreting cell
def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035929 ! capable of steroid hormone secretion
relationship: RO:0002215 GO:0035929 ! capable of steroid hormone secretion

[Term]
id: CL:0000183
name: contractile cell
def: "A cell whose primary function is to shorten." [FB:ma]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell

[Term]
id: CL:0000187
name: muscle cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_subset
subset: mouse_subset
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
xref: BTO:0000888
xref: BTO:0000902
xref: CALOHA:TS-2032
xref: FMA:67328
xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000393 ! electrically responsive cell
relationship: RO:0002202 CL:0000056 ! develops from myoblast

[Term]
id: CL:0000188
name: cell of skeletal muscle
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "skeletal muscle cell" EXACT []
xref: BTO:0004392
xref: CALOHA:TS-2158
xref: FMA:9727
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue
relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue

[Term]
id: CL:0000192
name: smooth muscle cell
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "myocytes, smooth muscle" EXACT [MESH:D032389]
synonym: "non-striated muscle cell" BROAD []
synonym: "SMCs" EXACT [PMID:9315361]
synonym: "smooth muscle fiber" EXACT []
xref: BTO:0004576
xref: CALOHA:TS-2159
xref: FMA:14072
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
relationship: RO:0002202 CL:0000514 ! develops from smooth muscle myoblast

[Term]
id: CL:0000197
name: sensory receptor cell
def: "A cell that is capable of detection of a stimulus involved in sensory perception." []
subset: human_subset
subset: mouse_subset
synonym: "receptor cell" EXACT []
xref: MESH:D011984
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system
intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception
relationship: BFO:0000050 UBERON:0001032 ! part of sensory system
relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception

[Term]
id: CL:0000206
name: chemoreceptor cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628]
subset: human_subset
subset: mouse_subset
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception
relationship: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception

[Term]
id: CL:0000209
name: taste receptor cell
def: "A specialized cell involved in gustatory sensory perception." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "taste bud cell" EXACT []
xref: FMA:67910
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000206 ! chemoreceptor cell
intersection_of: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste
relationship: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus involved in sensory perception of taste

[Term]
id: CL:0000210
name: photoreceptor cell
def: "A cell specialized in detecting light stimuli that are involved in visual perception." [MESH:D010786]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0001060
xref: CALOHA:TS-0868
xref: FMA:86740
is_a: CL:0000101 ! sensory neuron
is_a: CL:0008028 ! visual system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception
relationship: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception

[Term]
id: CL:0000211
name: electrically active cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell

[Term]
id: CL:0000214
name: synovial cell
def: "A cell located in the synovial joint." []
subset: human_subset
subset: mouse_subset
synonym: "synoviocyte" EXACT []
xref: CALOHA:TS-0995
is_a: CL:0002078 ! meso-epithelial cell
relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint

[Term]
id: CL:0000218
name: myelinating Schwann cell
def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:D012583]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neurilemmal cell" EXACT []
synonym: "peripheral neuroglial cell" BROAD []
synonym: "Schwann cell" BROAD []
xref: CALOHA:TS-0898
xref: FMA:62121
is_a: CL:0002573 ! Schwann cell
is_a: CL:4023154 ! myelinating glial cell
relationship: RO:0002202 CL:0002377 ! develops from immature Schwann cell

[Term]
id: CL:0000219
name: motile cell
def: "A cell that moves by its own activities." [FB:ma]
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0048870 ! capable of cell motility
relationship: RO:0002215 GO:0048870 ! capable of cell motility

[Term]
id: CL:0000221
name: ectodermal cell
def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "ectoderm cell" EXACT []
xref: FMA:72549
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm

[Term]
id: CL:0000222
name: mesodermal cell
def: "A cell of the middle germ layer of the embryo." [MESH:D008648]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
xref: FMA:72554
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm

[Term]
id: CL:0000223
name: endodermal cell
def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "endoderm cell" EXACT []
xref: FMA:72555
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000925 ! part of endoderm

[Term]
id: CL:0000225
name: anucleate cell
def: "A cell that lacks a nucleus." [FB:ma]
synonym: "non-nucleated cell" EXACT []
xref: FMA:68647
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001405 ! bearer of anucleate
relationship: RO:0000053 PATO:0001405 ! bearer of anucleate

[Term]
id: CL:0000226
name: single nucleate cell
def: "A cell with a single nucleus." [FB:ma, GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate
relationship: RO:0000053 PATO:0001407 ! bearer of mononucleate

[Term]
id: CL:0000228
name: multinucleate cell
def: "A cell with more than one nucleus." [FB:ma, Wikipedia:Multinucleate]
subset: human_subset
subset: mouse_subset
synonym: "multinucleated cells" EXACT [Wikipedia:Multinucleate]
synonym: "polynuclear cells" EXACT [Wikipedia:Multinucleate]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
relationship: RO:0000053 PATO:0001908 ! bearer of multinucleate

[Term]
id: CL:0000232
name: erythrocyte
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: BTO:0000424
xref: CALOHA:TS-0290
xref: FMA:81100
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: RO:0000053 PATO:0002039 ! bearer of biconcave
intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation
intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport
relationship: CL:4030045 GO:0005840 ! lacks_part ribosome
relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
relationship: RO:0000053 PATO:0002039 ! bearer of biconcave
relationship: RO:0002202 CL:0000558 ! develops from reticulocyte

[Term]
id: CL:0000234
name: phagocyte
def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0001044
xref: FMA:83806
xref: MESH:D010586
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis
relationship: RO:0002215 GO:0006909 ! capable of phagocytosis

[Term]
id: CL:0000235
name: macrophage
def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437]
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "histiocyte" EXACT []
xref: BTO:0000801
xref: CALOHA:TS-0587
xref: FMA:63261
xref: FMA:83585
xref: MESH:D008264
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
is_a: CL:0000766 ! myeloid leukocyte
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis
intersection_of: RO:0002215 GO:0031268 ! capable of pseudopodium organization
relationship: RO:0002202 CL:0000576 ! develops from monocyte
relationship: RO:0002215 GO:0031268 ! capable of pseudopodium organization

[Term]
id: CL:0000239
name: brush border epithelial cell
def: "An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption." []
comment: All brush border cells are columnar-cuboidal.  The formal logical definition of this term asserts this. Brush border epithelial cells are predominantly found lining the small intestine and the proximal tubules of the kidneys.
subset: human_subset
subset: mouse_subset
xref: https://doi.org/10.1152/ajpgi.00005.2011
xref: PMID:25422372
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000051 GO:0005903 ! has part brush border
relationship: BFO:0000051 GO:0005903 ! has part brush border

[Term]
id: CL:0000255
name: eukaryotic cell
def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
xref: MESH:D005057
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: CL:0000287
name: eye photoreceptor cell
def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000970 ! part of eye
relationship: BFO:0000050 UBERON:0000970 ! part of eye

[Term]
id: CL:0000295
name: somatotropin secreting cell
def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl]
subset: human_subset
subset: mouse_subset
synonym: "growth hormone secreting cell" EXACT []
synonym: "somatotrophin secreting cell" EXACT []
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0030252 ! capable of growth hormone secretion
relationship: RO:0002215 GO:0030252 ! capable of growth hormone secretion

[Term]
id: CL:0000300
name: gamete
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544]
subset: human_subset
subset: mouse_subset
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: CALOHA:TS-0395
xref: FMA:18649
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: RO:0000053 PATO:0001375 ! bearer of haploid
intersection_of: RO:0002215 GO:0009566 ! capable of fertilization
relationship: RO:0002215 GO:0009566 ! capable of fertilization

[Term]
id: CL:0000306
name: crystallin accumulating cell
subset: eye_upper_slim
subset: human_subset
subset: mouse_subset
synonym: "lens cell" EXACT []
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000307
name: tracheal epithelial cell
def: "An epithelial cell found in the trachea." [GOC:tfm]
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
subset: human_subset
subset: mouse_subset
synonym: "tracheocyte" EXACT []
xref: FMA:74793
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea
relationship: BFO:0000050 UBERON:0003126 ! part of trachea
relationship: RO:0002202 CL:0000377 ! develops from tracheoblast

[Term]
id: CL:0000313
name: serous secreting cell
def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "serous cell" EXACT []
xref: BTO:0003687
xref: FMA:62511
is_a: CL:0000159 ! seromucus secreting cell

[Term]
id: CL:0000325
name: stuff accumulating cell
def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma]
subset: human_subset
subset: mouse_subset
subset: ubprop:upper_level
is_a: CL:0000000 ! cell

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000329
name: oxygen accumulating cell
def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport
relationship: RO:0002215 GO:0015671 ! capable of oxygen transport

[Term]
id: CL:0000333
name: migratory neural crest cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017]
subset: human_subset
subset: mouse_subset
xref: FMA:86667
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
is_a: CL:0011026 ! progenitor cell
relationship: RO:0002202 CL:0007004 ! develops from premigratory neural crest cell

[Term]
id: CL:0000335
name: mesenchyme condensation cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0008019 ! mesenchymal cell

[Term]
id: CL:0000339
name: glioblast (sensu Vertebrata)
def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "spongioblast" EXACT []
xref: FMA:70564
is_a: CL:0000030 ! glioblast
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)

[Term]
id: CL:0000347
name: scleral cell
def: "A cell of the sclera of the eye." [GOC:add]
subset: eye_upper_slim
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera
relationship: BFO:0000050 UBERON:0001773 ! part of sclera
relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell

[Term]
id: CL:0000348
name: choroidal cell of the eye
def: "A cell that is part of optic choroid." [GOC:add]
subset: eye_upper_slim
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid
relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid
relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural crest cell

[Term]
id: CL:0000349
name: extraembryonic cell
def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure
relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure

[Term]
id: CL:0000351
name: trophoblast cell
def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [doi:10.1007/978-3-030-84725-8, GOC:tfm, MESH:D014327, PMID:37630754]
subset: human_subset
subset: mouse_subset
synonym: "trophoblastic cell" EXACT [doi:10.1007/978-3-030-84725-8]
xref: FMA:83028
is_a: CL:0000349 ! extraembryonic cell
relationship: RO:0002202 CL:1000274 ! develops from trophectodermal cell

[Term]
id: CL:0000352
name: epiblast cell
def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256]
subset: human_subset
subset: mouse_subset
is_a: CL:0000052 ! totipotent stem cell

[Term]
id: CL:0000353
name: blastoderm cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756]
subset: human_subset
subset: mouse_subset
synonym: "blastomere" EXACT []
xref: BTO:0001473
xref: FMA:72551
is_a: CL:0000007 ! early embryonic cell (metazoa)

[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570]
comment: Multi-potency demonstrated ex vivo.  At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
subset: human_subset
subset: mouse_subset
xref: FMA:86767
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue

[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
is_a: CL:0000192 ! smooth muscle cell
is_a: CL:4033054 ! perivascular cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002049 ! part of vasculature
relationship: BFO:0000050 UBERON:0002049 ! part of vasculature

[Term]
id: CL:0000362
name: epidermal cell
def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cell of epidermis" EXACT [FMA:62411]
synonym: "epithelial cell of skin" NARROW [FMA:62411]
xref: BTO:0001470
xref: CALOHA:TS-0283
xref: FMA:62411
xref: MESH:D000078404
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0007376 ! part of outer epithelium
relationship: BFO:0000050 UBERON:0007376 ! part of outer epithelium

[Term]
id: CL:0000365
name: animal zygote
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208]
subset: human_subset
subset: mouse_subset
synonym: "zygote" BROAD []
xref: BTO:0000854
xref: EHDAA2:0004546
xref: FMA:72395
is_a: CL:0000007 ! early embryonic cell (metazoa)
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0010017 ! zygote
intersection_of: CL:0010017 ! zygote
intersection_of: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: CL:0000377
name: tracheoblast
subset: human_subset
subset: mouse_subset
is_a: CL:0000069 ! branched duct epithelial cell

[Term]
id: CL:0000388
name: tendon cell
def: "An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance." [GOC:NV, GOC:tfm, PMID:37894875, PMID:957445]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "muscle attachment cell" EXACT []
synonym: "tenocyte" RELATED []
is_a: CL:1000307 ! fibroblast of dense regular elastic tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000043 ! part of tendon
relationship: BFO:0000050 UBERON:0000043 ! part of tendon

[Term]
id: CL:0000393
name: electrically responsive cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
subset: human_subset
subset: mouse_subset
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000397
name: ganglion interneuron
def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000045 ! has soma location ganglion
relationship: RO:0002100 UBERON:0000045 ! has soma location ganglion

[Term]
id: CL:0000404
name: electrically signaling cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma]
subset: human_subset
subset: mouse_subset
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000413
name: haploid cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001375 ! bearer of haploid
relationship: RO:0000053 PATO:0001375 ! bearer of haploid

[Term]
id: CL:0000438
name: luteinizing hormone secreting cell
def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0032275 ! capable of luteinizing hormone secretion
relationship: RO:0002215 GO:0032275 ! capable of luteinizing hormone secretion

[Term]
id: CL:0000439
name: prolactin secreting cell
def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl]
subset: human_subset
subset: mouse_subset
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0070459 ! capable of prolactin secretion
relationship: RO:0002215 GO:0070459 ! capable of prolactin secretion

[Term]
id: CL:0000440
name: melanocyte stimulating hormone secreting cell
def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl]
subset: human_subset
subset: mouse_subset
synonym: "melanotrope" EXACT []
synonym: "melanotroph" EXACT []
xref: BTO:0002277
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone secretion
relationship: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone secretion

[Term]
id: CL:0000447
name: carbohydrate secreting cell
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
xref: BTO:0002042
xref: CALOHA:TS-0194
xref: FMA:83036
xref: MESH:D003713
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: BFO:0000051 GO:0042613 ! has part MHC class II protein complex
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate
intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production
intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: RO:0002215 GO:0019882 ! capable of antigen processing and presentation
intersection_of: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation
disjoint_from: CL:0000542 ! lymphocyte
relationship: BFO:0000051 GO:0042613 ! has part MHC class II protein complex
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002215 GO:0001816 ! capable of cytokine production
relationship: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation

[Term]
id: CL:0000457
name: biogenic amine secreting cell
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000458
name: serotonin secreting cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576]
subset: human_subset
subset: mouse_subset
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0001820 ! capable of serotonin secretion
relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion

[Term]
id: CL:0000459
name: noradrenergic cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0048243 ! capable of norepinephrine secretion
relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion

[Term]
id: CL:0000467
name: adrenocorticotropic hormone secreting cell
def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl]
subset: human_subset
subset: mouse_subset
synonym: "ACTH secreting cell" EXACT [GO:0051458]
synonym: "adrenocorticotrophic hormone secreting cell" EXACT []
synonym: "corticotrophin hormone secreting cell" EXACT []
synonym: "corticotropin hormone secreting cell" EXACT []
synonym: "corticotropin secreting cell" EXACT [GO:0051458]
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0051458 ! capable of corticotropin secretion
relationship: RO:0002215 GO:0051458 ! capable of corticotropin secretion

[Term]
id: CL:0000488
name: visible light photoreceptor cell
def: "A photoreceptor cell that detects visible light." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: RO:0002215 GO:0009584 ! capable of detection of visible light
relationship: RO:0002215 GO:0009584 ! capable of detection of visible light

[Term]
id: CL:0000498
name: inhibitory interneuron
def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:84776
is_a: CL:0000099 ! interneuron

[Term]
id: CL:0000499
name: stromal cell
def: "A connective tissue cell of an organ found in the loose connective tissue." [GOC:tfm, MESH:D017154]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0002064
xref: FMA:83624
is_a: CL:0002320 ! connective tissue cell
relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell

[Term]
id: CL:0000513
name: cardiac muscle myoblast
def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cardiac muscle progenitor cell" EXACT []
synonym: "cardiomyocyte progenitor cell" EXACT []
xref: FMA:84797
is_a: CL:0002494 ! cardiocyte
is_a: CL:0010021 ! cardiac myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue
intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell
relationship: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue

[Term]
id: CL:0000514
name: smooth muscle myoblast
def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "myoblast, smooth muscle" EXACT [MESH:D032390]
synonym: "satellite cell" RELATED []
xref: FMA:84798
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0000192 ! develops into smooth muscle cell
relationship: RO:0002203 CL:0000192 ! develops into smooth muscle cell

[Term]
id: CL:0000515
name: skeletal muscle myoblast
def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "skeletal myoblast" EXACT []
xref: FMA:84799
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber
relationship: RO:0002202 CL:0000355 ! develops from multi-potent skeletal muscle stem cell
relationship: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber

[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000234 ! phagocyte
is_a: CL:0000255 ! eukaryotic cell
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>

[Term]
id: CL:0000521
name: fungal cell
def: "Any cell that in taxon some Fungi." [FBC:Autogenerated]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002162 NCBITaxon:4751 ! in taxon Fungi
relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "plasmidotrophoblast cell" RELATED []
synonym: "syncytial trophoblast cell" EXACT [PMID:11787150]
synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368]
synonym: "syntrophoblast cell" RELATED []
xref: FMA:83043
is_a: CL:0000351 ! trophoblast cell
is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
relationship: BFO:0000050 UBERON:0000371 ! part of syncytiotrophoblast

[Term]
id: CL:0000526
name: afferent neuron
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "input neuron" EXACT []
xref: FMA:87653
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000527
name: efferent neuron
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "output neuron" EXACT []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000540
name: neuron
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474]
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "nerve cell" EXACT []
xref: BTO:0000938
xref: CALOHA:TS-0683
xref: FMA:54527
xref: VHOG:0001483
xref: WBbt:0003679
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: RO:0002202 CL:0000031 {gci_filler="NCBITaxon:7742", gci_relation="RO:0002162", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! develops from neuroblast (sensu Vertebrata)
relationship: RO:0002215 GO:0019226 ! capable of transmission of nerve impulse

[Term]
id: CL:0000542
name: lymphocyte
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149]
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0000775
xref: CALOHA:TS-0583
xref: FMA:62863
xref: MESH:D008214
xref: VHOG:0001535
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm
intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate
intersection_of: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio
disjoint_from: CL:0000766 ! myeloid leukocyte
relationship: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm
relationship: BFO:0000051 GO:0000792 ! has part heterochromatin
relationship: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio
relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor

[Term]
id: CL:0000547
name: proerythroblast
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
xref: FMA:83518
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated
intersection_of: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
relationship: BFO:0000051 GO:0005730 ! has part nucleolus
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: RO:0002202 CL:0000038 ! develops from erythroid progenitor cell

[Term]
id: CL:0000549
name: basophilic erythroblast
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "basophilic normoblast" EXACT [ISBN:0721601464]
synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
xref: FMA:83505
is_a: CL:0000765 ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
relationship: BFO:0000051 GO:0000792 ! has part heterochromatin
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1

[Term]
id: CL:0000550
name: polychromatophilic erythroblast
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "intermediate erythroblast" EXACT [ISBN:0721601464]
synonym: "intermediate normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464]
synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
xref: FMA:83506
is_a: CL:0000765 ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm
intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm
relationship: BFO:0000051 GO:0000792 ! has part heterochromatin
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: RO:0002202 CL:0000549 ! develops from basophilic erythroblast

[Term]
id: CL:0000552
name: orthochromatic erythroblast
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "late erythoblast" EXACT []
synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464]
synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464]
xref: FMA:84646
is_a: CL:0000765 ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm
intersection_of: RO:0000056 GO:0030263 ! participates in apoptotic chromosome condensation
relationship: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm
relationship: RO:0000056 GO:0030263 ! participates in apoptotic chromosome condensation
relationship: RO:0002202 CL:0000550 ! develops from polychromatophilic erythroblast

[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
synonym: "colony-forming unit-megakaryocyte" EXACT []
synonym: "Meg-CFC" EXACT [PMCID:PMC1794060]
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498]
synonym: "MkP" EXACT [PMID:21116988]
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
xref: BTO:0001164
xref: CALOHA:TS-0610
xref: FMA:84235
xref: MESH:D055016
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle
intersection_of: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: RO:0002202 CL:0000050 ! develops from megakaryocyte-erythroid progenitor cell
relationship: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle
relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation

[Term]
id: CL:0000556
name: megakaryocyte
def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076]
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
xref: BTO:0000843
xref: CALOHA:TS-0611
xref: FMA:83555
is_a: CL:0000763 ! myeloid cell
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: RO:0000053 PATO:0001393 ! bearer of euploid
relationship: RO:0002202 CL:0000553 ! develops from megakaryocyte progenitor cell

[Term]
id: CL:0000557
name: granulocyte monocyte progenitor cell
def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566]
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow
intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
intersection_of: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor
intersection_of: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2
intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
intersection_of: RO:0002215 GO:0030225 ! capable of macrophage differentiation
intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation
relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
relationship: CL:4030045 PR:000007857 ! lacks_part erythroid transcription factor
relationship: CL:4030045 PR:000007858 ! lacks_part endothelial transcription factor GATA-2
relationship: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation
relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation

[Term]
id: CL:0000558
name: reticulocyte
def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0001173
xref: CALOHA:TS-0864
xref: MESH:D012156
is_a: CL:0000764 ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
intersection_of: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: RO:0002202 CL:0000552 ! develops from orthochromatic erythroblast
relationship: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly

[Term]
id: CL:0000559
name: promonocyte
def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464]
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0004657
xref: FMA:83551
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation
relationship: BFO:0000051 GO:0042582 ! has part azurophil granule
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002202 CL:0000040 ! develops from monoblast

[Term]
id: CL:0000562
name: nucleate erythrocyte
def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm]
subset: human_subset
subset: mouse_subset
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000232 ! erythrocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000232 ! erythrocyte
intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated
relationship: RO:0002202 CL:0002421 ! develops from nucleated reticulocyte

[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
subset: human_subset
subset: mouse_subset
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: RO:0002202 CL:0000134 ! develops from mesenchymal stem cell

[Term]
id: CL:0000568
name: amine precursor uptake and decarboxylation cell
def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544]
subset: human_subset
subset: mouse_subset
synonym: "APUD cell" EXACT []
xref: BTO:0003866
xref: FMA:83114
xref: MESH:D001078
is_a: CL:0000165 ! neuroendocrine cell

[Term]
id: CL:0000569
name: cardiac mesenchymal cell
def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0008019 ! mesenchymal cell
is_a: CL:2000073 ! migratory cardiac neural crest cell
intersection_of: CL:0008019 ! mesenchymal cell
intersection_of: RO:0002203 CL:0002494 ! develops into cardiocyte
relationship: RO:0002203 CL:0002494 ! develops into cardiocyte

[Term]
id: CL:0000573
name: retinal cone cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001036
xref: CALOHA:TS-0866
xref: FMA:67748
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: RO:0002202 CL:0002672 ! develops from retinal progenitor cell

[Term]
id: CL:0000575
name: corneal epithelial cell
def: "An epithelial cell of the cornea." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "epithelial cell of cornea" EXACT [FMA:70551]
xref: BTO:0004298
xref: CALOHA:TS-0173
xref: FMA:70551
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0001772 ! part of corneal epithelium
relationship: BFO:0000050 UBERON:0001772 ! part of corneal epithelium

[Term]
id: CL:0000576
name: monocyte
def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000]
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0000876
xref: CALOHA:TS-0638
xref: FMA:62864
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate
intersection_of: RO:0002215 GO:0030225 ! capable of macrophage differentiation
intersection_of: RO:0002215 GO:0030316 ! capable of osteoclast differentiation
intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation
relationship: RO:0002202 CL:0000559 ! develops from promonocyte
relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation
relationship: RO:0002215 GO:0030316 ! capable of osteoclast differentiation
relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation

[Term]
id: CL:0000586
name: germ cell
def: "The reproductive cell in multicellular organisms." [MESH:D005854]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0000535
xref: NCIT:C12597
xref: VHOG:0001534
xref: WBbt:0006796
is_a: CL:0000039 ! germ line cell
relationship: RO:0002216 GO:0009566 ! capable of part of fertilization

[Term]
id: CL:0000593
name: androgen secreting cell
def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0035935 ! capable of androgen secretion
relationship: RO:0002215 GO:0035935 ! capable of androgen secretion

[Term]
id: CL:0000596
name: sexual spore
def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt]
synonym: "meiotically-derived spore" EXACT []
xref: FAO:0000017
is_a: CL:0002369 ! fungal spore

[Term]
id: CL:0000598
name: pyramidal neuron
def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:D017966]
subset: BDS_subset
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "projection neuron" EXACT []
synonym: "pyramidal cell" EXACT []
xref: BTO:0003102
xref: FMA:67310
xref: FMA:86775
xref: NIFSTD:sao862606388
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0000053 PATO:0070015 ! bearer of pyramidal family morphology
relationship: RO:0000053 PATO:0070015 ! bearer of pyramidal family morphology

[Term]
id: CL:0000604
name: retinal rod cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001024
xref: CALOHA:TS-0870
xref: FMA:67747
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: RO:0002202 CL:0002672 ! develops from retinal progenitor cell

[Term]
id: CL:0000605
name: fungal asexual spore
def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt]
xref: FAO:0000023
is_a: CL:0002369 ! fungal spore

[Term]
id: CL:0000617
name: GABAergic neuron
def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "GABA-ergic neuron" EXACT []
xref: FMA:84788
xref: MESH:D059330
xref: WBbt:0005190
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
relationship: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission

[Term]
id: CL:0000622
name: acinar cell
def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "acinic cell" EXACT []
synonym: "acinous cell" EXACT []
xref: FMA:83625
xref: MESH:D061354
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000154 ! protein secreting cell
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: CL:0000154 ! protein secreting cell
intersection_of: BFO:0000050 UBERON:0009842 ! part of glandular acinus
relationship: BFO:0000050 UBERON:0009842 ! part of glandular acinus

[Term]
id: CL:0000630
name: supporting cell
def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "supportive cell" EXACT []
xref: BTO:0002315
is_a: CL:0000000 ! cell

[Term]
id: CL:0000637
name: chromophil cell of anterior pituitary gland
def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256]
subset: human_subset
subset: mouse_subset
xref: FMA:83089
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000166 ! chromaffin cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0012001 ! neuron of the forebrain
is_a: CL:2000004 ! pituitary gland cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0002196 ! part of adenohypophysis
relationship: BFO:0000050 UBERON:0002196 ! part of adenohypophysis

[Term]
id: CL:0000638
name: acidophil cell of pars distalis of adenohypophysis
def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars anterior of adenohypophysis" EXACT []
synonym: "acidophil of pars distalis of adenohypophysis" EXACT []
synonym: "pituitary alpha cell" EXACT []
xref: FMA:83093
is_a: CL:0000637 ! chromophil cell of anterior pituitary gland
relationship: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis

[Term]
id: CL:0000642
name: folliculostellate cell
def: "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." [doi:10.23937/2572-407X.1510006, JB:jb, PMID:10495875, PMID:15961560]
comment: Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets. {xref="doi:10.23937/2572-407X.1510006", xref="PMID:34734454", xref="PMID:31620083", xref="PMID:18287078"}
subset: human_subset
subset: mouse_subset
synonym: "folliculo-stellate cell" EXACT [doi:10.23937/2572-407X.1510006]
synonym: "pituitary folliculostellate cell" EXACT [PMID:34734454]
synonym: "Sox2-positive stem cell" RELATED [PMID:34734454]
is_a: CL:0000630 ! supporting cell
is_a: CL:2000004 ! pituitary gland cell
relationship: BFO:0000050 UBERON:0002196 ! part of adenohypophysis

[Term]
id: CL:0000644
name: Bergmann glial cell
def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "Bergmann astrocyte" EXACT []
synonym: "Bergmann glial cell of cerebellum" EXACT []
xref: FMA:54559
is_a: CL:0002603 ! astrocyte of the cerebellum
relationship: BFO:0000050 UBERON:0002979 ! part of Purkinje cell layer of cerebellar cortex

[Term]
id: CL:0000652
name: pinealocyte
def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0001068
xref: FMA:83417
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002319 ! neural cell
relationship: BFO:0000050 UBERON:0001905 ! part of pineal body
relationship: RO:0002215 GO:0030187 ! capable of melatonin biosynthetic process

[Term]
id: CL:0000666
name: fenestrated endothelial cell
def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "window cell" EXACT []
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: RO:0000053 PATO:0002064 ! bearer of fenestrated
relationship: RO:0000053 PATO:0002064 ! bearer of fenestrated

[Term]
id: CL:0000667
name: collagen secreting cell
def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000670
name: primordial germ cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "gonocyte" EXACT []
synonym: "primitive germ cell" EXACT []
xref: FMA:70567
is_a: CL:0000039 ! germ line cell
is_a: CL:0000219 ! motile cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo
intersection_of: RO:0002215 GO:0048870 ! capable of cell motility
relationship: BFO:0000050 UBERON:0000922 ! part of embryo

[Term]
id: CL:0000675
name: female gamete
def: "A mature sexual reproductive cell of the female germline." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000021 ! female germ cell
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000679
name: glutamatergic neuron
def: "A neuron that is capable of some neurotansmission by glutamate secretion." []
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: WBbt:0006829
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission
relationship: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:0000680
name: muscle precursor cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: RO:0002203 CL:0000187 ! develops into muscle cell
relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell
relationship: RO:0002203 CL:0000187 ! develops into muscle cell

[Term]
id: CL:0000681
name: radial glial cell
def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph]
comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "forebrain radial glial cell" NARROW []
is_a: CL:0000125 ! glial cell
relationship: RO:0002202 CL:0000710 ! develops from neurecto-epithelial cell

[Term]
id: CL:0000686
name: cerebrospinal fluid secreting cell
def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion
relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion

[Term]
id: CL:0000691
name: stellate interneuron
def: "Any interneuron that has characteristic some stellate morphology." [FBC:Autogenerated]
subset: BDS_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000099 ! interneuron
is_a: CL:0000122 ! stellate neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0000053 PATO:0070010 ! bearer of stellate morphology

[Term]
id: CL:0000700
name: dopaminergic neuron
def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "dopaminergic cell" EXACT []
xref: BTO:0004032
xref: FMA:84787
xref: MESH:D059290
xref: WBbt:0006746
is_a: CL:4033050 ! catecholaminergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061527 ! capable of dopamine secretion, neurotransmission
relationship: RO:0002215 GO:0061527 ! capable of dopamine secretion, neurotransmission

[Term]
id: CL:0000706
name: choroid plexus epithelial cell
def: "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF." [GOC:add, GOC:tfm, JB:jb, PMID:15561411, PMID:9550134]
comment: A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions. {xref="PMID:25729351"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "choroid plexus cell" BROAD [DOI:10.1101/2022.10.12.511898]
synonym: "epithelial cell of choroid plexus" EXACT []
xref: FMA:70549
is_a: CL:0000065 ! ependymal cell
is_a: CL:0000239 ! brush border epithelial cell
intersection_of: CL:0000065 ! ependymal cell
intersection_of: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium
relationship: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium
relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion

[Term]
id: CL:0000710
name: neurecto-epithelial cell
def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm]
comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
subset: human_subset
subset: mouse_subset
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
xref: FMA:70557
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
intersection_of: CL:0002077 ! ecto-epithelial cell
intersection_of: RO:0002202 CL:0000133 ! develops from neurectodermal cell
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell

[Term]
id: CL:0000723
name: somatic stem cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: CALOHA:TS-2086
xref: MESH:D053687
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000034 ! stem cell
intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division
relationship: RO:0002215 GO:0048103 ! capable of somatic stem cell division

[Term]
id: CL:0000737
name: striated muscle cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544]
subset: human_subset
subset: mouse_subset
xref: BTO:0002916
xref: CALOHA:TS-2157
xref: FMA:86936
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere
intersection_of: RO:0000053 PATO:0001410 ! bearer of striated
disjoint_from: CL:0008000 ! non-striated muscle cell
relationship: BFO:0000051 GO:0030017 ! has part sarcomere
relationship: RO:0000053 PATO:0001410 ! bearer of striated

[Term]
id: CL:0000738
name: leukocyte
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "immune cell" RELATED []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
xref: BTO:0000751
xref: CALOHA:TS-0549
xref: FMA:62852
xref: MESH:D007962
xref: NCIT:C12529
is_a: CL:0000219 ! motile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated
intersection_of: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration
relationship: BFO:0000050 UBERON:0002405 ! part of immune system
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell
relationship: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration

[Term]
id: CL:0000740
name: retinal ganglion cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
is_a: CL:0000540 ! neuron
relationship: RO:0002100 UBERON:0000966 ! has soma location retina

[Term]
id: CL:0000746
name: cardiac muscle cell
def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263]
comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods.  The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein).  According to these refs, the cells participating in heart contraction in all cases are transversely striated.  Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "cardiac muscle fiber" EXACT [GO:0048739]
synonym: "cardiac myocyte" EXACT []
synonym: "cardiocyte" BROAD []
synonym: "cardiomyocyte" EXACT []
synonym: "heart muscle cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:14067
xref: MESH:D032383
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ
intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere
intersection_of: RO:0000053 PATO:0002478 ! bearer of transversely striated
intersection_of: RO:0000056 GO:0060047 ! participates in heart contraction
relationship: RO:0000053 PATO:0002478 ! bearer of transversely striated
relationship: RO:0000056 GO:0060047 ! participates in heart contraction
relationship: RO:0002202 CL:0000513 ! develops from cardiac muscle myoblast

[Term]
id: CL:0000763
name: myeloid cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0001441
xref: CALOHA:TS-0647
xref: MESH:D022423
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor
relationship: RO:0002202 CL:0000049 ! develops from common myeloid progenitor

[Term]
id: CL:0000764
name: erythroid lineage cell
def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm]
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "erythropoietic cell" EXACT []
xref: CALOHA:TS-0290
xref: FMA:62845
xref: FMA:83516
is_a: CL:0000763 ! myeloid cell

[Term]
id: CL:0000765
name: erythroblast
def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "normoblast" EXACT []
xref: BTO:0001571
xref: CALOHA:TS-0289
xref: FMA:83504
xref: MESH:D004900
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: BFO:0000051 GO:0005634 ! has part nucleus
intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation
relationship: BFO:0000051 GO:0005634 ! has part nucleus
relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: RO:0002202 CL:0000547 ! develops from proerythroblast
relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation

[Term]
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000738 ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor

[Term]
id: CL:0000778
name: mononuclear osteoclast
def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452]
comment: Morphology: mononuclear, highly vesicular.
subset: human_subset
subset: mouse_subset
is_a: CL:0000092 ! osteoclast
is_a: CL:0000113 ! mononuclear phagocyte
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate

[Term]
id: CL:0000779
name: multinuclear osteoclast
def: "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:29379067, PMID:38903088, PMID:9415452]
comment: Morphology: multinucleated, highly vesicular.
subset: human_subset
subset: mouse_subset
synonym: "multinucleated osteoclast" EXACT []
is_a: CL:0000092 ! osteoclast
is_a: CL:0000783 ! multinucleated phagocyte
is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
relationship: RO:0002202 CL:0000778 ! develops from mononuclear osteoclast

[Term]
id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
synonym: "veiled cell" BROAD []
xref: BTO:0004721
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
intersection_of: RO:0002202 CL:0000763 ! develops from myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: RO:0002202 CL:0000763 ! develops from myeloid cell

[Term]
id: CL:0000783
name: multinucleated phagocyte
def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate

[Term]
id: CL:0000827
name: pro-T cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030217 ! capable of T cell differentiation
relationship: RO:0002202 CL:0000051 ! develops from common lymphoid progenitor
relationship: RO:0002215 GO:0030217 ! capable of T cell differentiation

[Term]
id: CL:0000835
name: myeloblast
def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464]
subset: human_subset
subset: mouse_subset
xref: BTO:0000187
xref: FMA:83524
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin
intersection_of: CL:4030045 GO:0042582 ! lacks_part azurophil granule
intersection_of: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio
relationship: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
relationship: BFO:0000051 GO:0000791 ! has part euchromatin
relationship: CL:4030045 GO:0042582 ! lacks_part azurophil granule
relationship: RO:0000053 PATO:0040072 ! bearer of high nuclear/cytoplasmic ratio
relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell

[Term]
id: CL:0000837
name: hematopoietic multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770]
comment: Markers differ between mouse and human.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0000053 PATO:0001402 ! bearer of multipotent
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: RO:0000053 PATO:0001402 ! bearer of multipotent
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell

[Term]
id: CL:0000838
name: lymphoid lineage restricted progenitor cell
def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm]
comment: Note that this is a class of cell types, not an identified single cell type.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "lymphoid progenitor cell" BROAD []
xref: BTO:0004731
xref: CALOHA:TS-2025
xref: FMA:70338
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation
disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation

[Term]
id: CL:0000839
name: myeloid lineage restricted progenitor cell
def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770]
comment: Note that this is a class of cell types, not an identified single cell type.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "myeloid progenitor cell" BROAD []
xref: BTO:0004730
xref: CALOHA:TS-2099
xref: FMA:70339
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation
relationship: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation

[Term]
id: CL:0000842
name: mononuclear leukocyte
def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "mononuclear cell" EXACT []
synonym: "peripheral blood mononuclear cell" NARROW []
xref: BTO:0000878
xref: CALOHA:TS-0768
xref: FMA:86713
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate

[Term]
id: CL:0000850
name: serotonergic neuron
def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
xref: MESH:D059326
xref: WBbt:0006837
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0060096 ! capable of serotonin secretion, neurotransmission
relationship: RO:0002215 GO:0060096 ! capable of serotonin secretion, neurotransmission

[Term]
id: CL:0000860
name: classical monocyte
def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168]
comment: Markers: CCR2+CXCCR1<low> (human, mouse, rat).
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "inflammatory monocyte" EXACT []
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis
intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis
intersection_of: RO:0002215 GO:0006954 ! capable of inflammatory response
intersection_of: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis
relationship: RO:0002215 GO:0006954 ! capable of inflammatory response
relationship: RO:0015015 PR:000001199 ! has high plasma membrane amount C-C chemokine receptor type 2

[Term]
id: CL:0000861
name: elicited macrophage
def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589]
comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "free macrophage" EXACT []
synonym: "wandering histiocyte" EXACT []
xref: FMA:84643
xref: FMA:84645
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: RO:0000056 GO:0006954 ! participates in inflammatory response
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
intersection_of: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin
relationship: RO:0000056 GO:0006954 ! participates in inflammatory response
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
relationship: RO:0002104 PR:000002064 ! has plasma membrane part macrosialin
relationship: RO:0002202 CL:0000860 ! develops from classical monocyte

[Term]
id: CL:0000862
name: suppressor macrophage
def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419]
comment: Markers: May express: IL10, TGFbeta.
subset: human_subset
subset: mouse_subset
is_a: CL:0000861 ! elicited macrophage
intersection_of: CL:0000861 ! elicited macrophage
intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response
relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune response

[Term]
id: CL:0000864
name: tissue-resident macrophage
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "fixed macrophage" EXACT []
synonym: "resting histiocyte" EXACT []
xref: FMA:84642
xref: FMA:84644
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: BFO:0000050 UBERON:0000479 ! part of tissue
relationship: BFO:0000050 UBERON:0000479 ! part of tissue

[Term]
id: CL:0000878
name: central nervous system macrophage
def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "CNS macrophage" EXACT []
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system
relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system

[Term]
id: CL:0000988
name: hematopoietic cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_subset
subset: mouse_subset
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
xref: BTO:0000574
xref: CALOHA:TS-2017
xref: FMA:70366
xref: FMA:83598
is_a: CL:0000000 ! cell

[Term]
id: CL:0000990
name: conventional dendritic cell
def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "cDC" EXACT []
synonym: "DC1" EXACT []
synonym: "dendritic reticular cell" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
xref: FMA:84191
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X
relationship: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X

[Term]
id: CL:0000995
name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).
subset: human_subset
subset: mouse_subset
synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD []
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
is_a: CL:0011026 ! progenitor cell
union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor
union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor

[Term]
id: CL:0001012
name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).
subset: human_subset
subset: mouse_subset
is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative
is_a: CL:0011026 ! progenitor cell
union_of: CL:0000557 ! granulocyte monocyte progenitor cell
union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell

[Term]
id: CL:0001019
name: CD115-positive monocyte OR common dendritic progenitor
comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617).
subset: human_subset
subset: mouse_subset
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
union_of: CL:0001022 ! CD115-positive monocyte
union_of: CL:0001029 ! common dendritic progenitor

[Term]
id: CL:0001021
name: CD34-positive, CD38-positive common lymphoid progenitor
def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770]
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).
subset: human_subset
subset: mouse_subset
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin
relationship: RO:0002202 CL:0002043 ! develops from CD34-positive, CD38-negative multipotent progenitor cell

[Term]
id: CL:0001022
name: CD115-positive monocyte
def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617).
subset: human_subset
subset: mouse_subset
is_a: CL:0000576 ! monocyte
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0000576 ! monocyte
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0002202 CL:0002001 ! develops from CD34-positive, CD38-positive granulocyte monocyte progenitor

[Term]
id: CL:0001024
name: CD34-positive, CD38-negative hematopoietic stem cell
def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721]
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871]
xref: CALOHA:TS-0448
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
intersection_of: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1
intersection_of: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein
intersection_of: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
relationship: CL:4030046 PR:000001892 ! lacks_plasma_membrane_part CD33 molecule
relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001786 ! has plasma membrane part prominin-1
relationship: RO:0002104 PR:000001809 ! has plasma membrane part CD59-like glycoprotein
relationship: RO:0002104 PR:000001843 ! has plasma membrane part Thy-1 membrane glycoprotein

[Term]
id: CL:0001026
name: CD34-positive, CD38-positive common myeloid progenitor
def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251]
comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).
subset: human_subset
subset: mouse_subset
synonym: "CD71-positive common myeloid precursor" NARROW []
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
is_a: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
intersection_of: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha
intersection_of: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
relationship: CL:4030046 PR:000001867 ! lacks_plasma_membrane_part interleukin-5 receptor subunit alpha
relationship: CL:4030046 PR:000001898 ! lacks_plasma_membrane_part neprilysin
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002202 CL:0002043 ! develops from CD34-positive, CD38-negative multipotent progenitor cell
relationship: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain

[Term]
id: CL:0001027
name: CD7-negative lymphoid progenitor cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).
subset: human_subset
subset: mouse_subset
synonym: "CD7-negative lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002202 CL:0001021 ! develops from CD34-positive, CD38-positive common lymphoid progenitor

[Term]
id: CL:0001028
name: CD7-positive lymphoid progenitor cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).
subset: human_subset
subset: mouse_subset
synonym: "CD7-positive lymphoid precursor" EXACT []
is_a: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule
relationship: RO:0002202 CL:0001027 ! develops from CD7-negative lymphoid progenitor cell

[Term]
id: CL:0001029
name: common dendritic progenitor
def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519]
comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "CDP" EXACT [PMID:21219184]
synonym: "common dendritic precursor" EXACT []
synonym: "pro-DCs" EXACT [PMID:21219184]
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
relationship: RO:0002202 CL:0002009 ! develops from macrophage dendritic cell progenitor
relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor

[Term]
id: CL:0001031
name: cerebellar granule cell
def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." [doi:10.12688/f1000research.15021.1, doi:10.3389/fncir.2020.611841, GOC:mah]
comment: It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells. {xref="doi:10.3389/fncir.2020.611841"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "granule cell of the cerebellum" EXACT [doi:10.3389/fncir.2020.611841]
xref: BTO:0004278
is_a: CL:0000120 ! granule cell
is_a: CL:2000028 ! cerebellum glutamatergic neuron
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
relationship: RO:0002207 CL:0002362 ! directly develops from cerebellar granule cell precursor

[Term]
id: CL:0001032
name: cortical granule cell
def: "Granule cell that is part of the cerebral cortex." [GOC:mah]
subset: human_subset
subset: mouse_subset
is_a: CL:0000120 ! granule cell
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex

[Term]
id: CL:0001035
name: bone cell
def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add]
subset: general_cell_types_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element
relationship: BFO:0000050 UBERON:0001474 ! part of bone element
creation_date: 2011-11-16T04:28:16Z

[Term]
id: CL:0001054
name: CD14-positive monocyte
def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "monocyte" NARROW [PMID:22343568]
is_a: CL:0000576 ! monocyte
intersection_of: CL:0000576 ! monocyte
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: RO:0002104 PR:000001889 ! has plasma membrane part CD14 molecule

[Term]
id: CL:0001059
name: common myeloid progenitor, CD34-positive
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566]
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: human_subset
subset: mouse_subset
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
is_a: CL:0000049 ! common myeloid progenitor
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000049 ! common myeloid progenitor
intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor
intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002215 GO:0002573 ! capable of myeloid leukocyte differentiation
intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation
relationship: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
relationship: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
relationship: BFO:0000051 PR:000007857 ! has part erythroid transcription factor
relationship: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation

[Term]
id: CL:0001060
name: hematopoietic oligopotent progenitor cell, lineage-negative
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770]
subset: human_subset
subset: mouse_subset
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0000053 PATO:0001401 ! bearer of oligopotent
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0001061
name: abnormal cell
def: "A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models." [GOC:add, GOC:cg, GOC:wdd]
comment: https://github.com/obophenotype/cell-ontology/issues/448
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0000460 ! bearer of abnormal
relationship: RO:0000053 PATO:0000460 ! bearer of abnormal

[Term]
id: CL:0001065
name: innate lymphoid cell
def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: RO:0002215 GO:0001816 ! capable of cytokine production
intersection_of: RO:0002215 GO:0045087 ! capable of innate immune response
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: RO:0002215 GO:0001816 ! capable of cytokine production
relationship: RO:0002215 GO:0045087 ! capable of innate immune response

[Term]
id: CL:0001066
name: erythroid progenitor cell, mammalian
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000038 ! erythroid progenitor cell
intersection_of: CL:0000038 ! erythroid progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
intersection_of: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin receptor protein 1
relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation

[Term]
id: CL:0002001
name: CD34-positive, CD38-positive granulocyte monocyte progenitor
def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770]
comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population.
subset: human_subset
subset: mouse_subset
is_a: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: RO:0002104 PR:000001865 ! has plasma membrane part interleukin-3 receptor class 2 alpha chain
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: RO:0002202 CL:0001026 ! develops from CD34-positive, CD38-positive common myeloid progenitor
creation_date: 2010-01-13T03:19:22Z

[Term]
id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700]
comment: Markers are associated with human cell type.
subset: human_subset
subset: mouse_subset
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
creation_date: 2010-01-13T03:43:10Z

[Term]
id: CL:0002009
name: macrophage dendritic cell progenitor
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "MDP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation
intersection_of: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation
relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progenitor cell
relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation
relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation
creation_date: 2010-01-19T02:51:58Z

[Term]
id: CL:0002010
name: pre-conventional dendritic cell
def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002202 CL:0001029 ! develops from common dendritic progenitor
creation_date: 2010-01-19T03:39:30Z

[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770]
subset: blood_and_immune_upper_slim
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001400 ! bearer of unipotent
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: RO:0000053 PATO:0001400 ! bearer of unipotent
relationship: RO:0002202 CL:0002032 ! develops from hematopoietic oligopotent progenitor cell
creation_date: 2010-01-06T03:43:20Z

[Term]
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770]
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell.  For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001401 ! bearer of oligopotent
relationship: RO:0000053 PATO:0001401 ! bearer of oligopotent
relationship: RO:0002202 CL:0000837 ! develops from hematopoietic multipotent progenitor cell
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0002043
name: CD34-positive, CD38-negative multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770]
comment: Cell markers are associated with human hematopoietic multipotent progenitor cells.
subset: human_subset
subset: mouse_subset
is_a: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
intersection_of: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
relationship: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
relationship: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
relationship: CL:4030046 PR:000001843 ! lacks_plasma_membrane_part Thy-1 membrane glycoprotein
relationship: RO:0002202 CL:0001024 ! develops from CD34-positive, CD38-negative hematopoietic stem cell
creation_date: 2010-01-12T11:14:15Z

[Term]
id: CL:0002068
name: Purkinje myocyte
def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "myocytus conducens cardiacus" EXACT []
synonym: "Purkinje cell fiber" EXACT []
synonym: "Purkinje muscle cell" EXACT []
xref: BTO:0001032
xref: FMA:14146
is_a: CL:0002086 ! specialized cardiac myocyte
creation_date: 2010-06-28T08:36:15Z

[Term]
id: CL:0002072
name: nodal myocyte
def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "cardiac pacemaker cell" EXACT [GOC:pr]
synonym: "myocytus nodalis" EXACT []
synonym: "P cell" EXACT []
synonym: "pacemaker cell" BROAD []
xref: BTO:0004190
xref: FMA:67101
is_a: CL:0002086 ! specialized cardiac myocyte
creation_date: 2010-06-29T11:41:37Z

[Term]
id: CL:0002073
name: transitional myocyte
def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:67142
is_a: CL:0002086 ! specialized cardiac myocyte
creation_date: 2010-06-29T02:39:32Z

[Term]
id: CL:0002074
name: myocardial endocrine cell
def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:67111
is_a: CL:0000163 ! endocrine cell
is_a: CL:0002086 ! specialized cardiac myocyte
creation_date: 2010-06-29T11:50:47Z

[Term]
id: CL:0002076
name: endo-epithelial cell
def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:69075
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002202 CL:0000223 ! develops from endodermal cell
relationship: RO:0002202 CL:0000223 ! develops from endodermal cell
creation_date: 2010-06-29T03:38:14Z

[Term]
id: CL:0002077
name: ecto-epithelial cell
def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:69074
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002202 CL:0000221 ! develops from ectodermal cell
relationship: RO:0002202 CL:0000221 ! develops from ectodermal cell
creation_date: 2010-06-29T03:38:22Z

[Term]
id: CL:0002078
name: meso-epithelial cell
def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: RO:0002202 CL:0000222 ! develops from mesodermal cell
relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell
creation_date: 2010-06-29T03:49:14Z

[Term]
id: CL:0002085
name: tanycyte
def: "A specialized elongated ventricular ependymal cell with one or more processes that extend into the brain parenchyma or associated blood vessels where they contact blood vessel endothelial cells and/or neurons. These cells are found in the ventricles and circumventricular organs of the brain. They are involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte, PMID:29351662]
comment: This class includes cells that are sometimes referred to as tanycyte-like cells,  located in circumventricular organs (Langlet et al., 2023) as well as tanycytes located in the ventricles. {xref="PMID:23649873"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "stretch cell" EXACT [PMID:29351662]
synonym: "tanycyte-like cell" NARROW [PMID:23649873]
xref: BTO:0001953
xref: FMA:54560
is_a: CL:0000065 ! ependymal cell
creation_date: 2010-07-15T11:21:11Z

[Term]
id: CL:0002086
name: specialized cardiac myocyte
def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:67968
is_a: CL:0000746 ! cardiac muscle cell
creation_date: 2010-07-21T01:33:38Z

[Term]
id: CL:0002087
name: nongranular leukocyte
def: "A leukocyte that lacks granules." [GOC:tfm]
subset: blood_and_immune_upper_slim
subset: human_subset
subset: mouse_subset
synonym: "agranular leukocyte" EXACT []
xref: FMA:62855
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule
relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule
creation_date: 2010-07-22T11:30:33Z

[Term]
id: CL:0002092
name: bone marrow cell
def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256]
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0004850
xref: FMA:83621
xref: MESH:D001854
is_a: CL:0001035 ! bone cell
intersection_of: CL:0001035 ! bone cell
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow
relationship: BFO:0000050 UBERON:0002371 ! part of bone marrow
creation_date: 2010-07-22T04:48:15Z

[Term]
id: CL:0002095
name: hilus cell of ovary
def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "hilar cell of ovary" EXACT []
xref: FMA:18710
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002132 ! stromal cell of ovary
creation_date: 2010-08-23T11:18:18Z

[Term]
id: CL:0002132
name: stromal cell of ovary
def: "A stomal cell of the ovary" [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "ovarian stromal cell" EXACT [GOC:cjm]
xref: FMA:72299
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary
relationship: BFO:0000050 UBERON:0000992 ! part of ovary
creation_date: 2010-08-23T12:10:31Z

[Term]
id: CL:0002139
name: endothelial cell of vascular tree
def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cubodial endothelial cell of vascular tree" NARROW []
synonym: "vascular endothelial cell" EXACT []
xref: BTO:0001854
xref: CALOHA:TS-1106
xref: FMA:67755
is_a: CL:0000115 ! endothelial cell
creation_date: 2010-08-24T02:06:40Z

[Term]
id: CL:0002144
name: capillary endothelial cell
def: "An endothelial cell found in capillaries." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0004956
xref: CALOHA:TS-0112
xref: FMA:67756
is_a: CL:0002653 ! squamous endothelial cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary
relationship: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary
creation_date: 2010-08-24T10:15:00Z

[Term]
id: CL:0002159
name: general ecto-epithelial cell
def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:70556
is_a: CL:0002077 ! ecto-epithelial cell
creation_date: 2010-08-26T08:31:08Z

[Term]
id: CL:0002177
name: folliculostellate cell of pars distalis of adenohypophysis
def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT []
xref: FMA:83102
is_a: CL:0000642 ! folliculostellate cell
is_a: CL:0000710 ! neurecto-epithelial cell
intersection_of: CL:0000642 ! folliculostellate cell
intersection_of: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis
relationship: BFO:0000050 UBERON:0006964 ! part of pars distalis of adenohypophysis
creation_date: 2010-08-25T03:10:10Z

[Term]
id: CL:0002191
name: granulocytopoietic cell
def: "A cell involved in the formation of a granulocyte." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:83519
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation
relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation
creation_date: 2010-08-30T12:54:27Z

[Term]
id: CL:0002194
name: monopoietic cell
def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:83552
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation
relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation
creation_date: 2010-08-30T01:27:48Z

[Term]
id: CL:0002202
name: epithelial cell of tracheobronchial tree
def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:66816
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium
relationship: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium
creation_date: 2010-09-02T02:09:14Z

[Term]
id: CL:0002209
name: intermediate epitheliocyte
def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651]
subset: human_subset
subset: mouse_subset
synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT []
xref: FMA:69060
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
creation_date: 2010-09-02T02:53:59Z

[Term]
id: CL:0002220
name: interstitial cell of pineal gland
def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651]
subset: human_subset
subset: mouse_subset
xref: FMA:86575
is_a: CL:0000710 ! neurecto-epithelial cell
creation_date: 2010-09-02T04:28:41Z

[Term]
id: CL:0002222
name: vertebrate lens cell
def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544]
subset: eye_upper_slim
subset: human_subset
subset: mouse_subset
xref: FMA:70950
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000306 ! crystallin accumulating cell
relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye
creation_date: 2010-09-07T10:38:03Z

[Term]
id: CL:0002224
name: lens epithelial cell
def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:67559
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002222 ! vertebrate lens cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: BFO:0000050 UBERON:0001803 ! part of epithelium of lens
relationship: BFO:0000050 UBERON:0001803 ! part of epithelium of lens
creation_date: 2010-09-07T10:45:47Z

[Term]
id: CL:0002240
name: marrow fibroblast
def: "A fibroblast in the bone marrow." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:84377
is_a: CL:0000057 ! fibroblast
is_a: CL:0010001 ! stromal cell of bone marrow
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow
creation_date: 2010-09-07T02:25:18Z

[Term]
id: CL:0002242
name: nucleate cell
def: "A cell containing at least one nucleus." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:67513
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated
relationship: RO:0000053 PATO:0002505 ! bearer of nucleated
creation_date: 2010-09-07T03:32:33Z

[Term]
id: CL:0002246
name: peripheral blood stem cell
def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "PBSC" EXACT []
xref: BTO:0002669
xref: FMA:86711
xref: MESH:D000072916
is_a: CL:0000037 ! hematopoietic stem cell
is_a: CL:0000080 ! circulating cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: BFO:0000050 UBERON:0000178 ! part of blood
relationship: BFO:0000050 UBERON:0000178 ! part of blood
creation_date: 2010-09-07T03:57:09Z

[Term]
id: CL:0002251
name: epithelial cell of alimentary canal
def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544]
subset: human_subset
subset: mouse_subset
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium
relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium
creation_date: 2010-09-08T09:26:53Z

[Term]
id: CL:0002252
name: epithelial cell of esophagus
def: "An epithelial cell of the lining of the esophagus." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:63071
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus
relationship: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus
creation_date: 2010-09-08T09:28:20Z

[Term]
id: CL:0002262
name: endothelial cell of sinusoid
def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:63134
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0003909 ! part of sinusoid
relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid
creation_date: 2010-09-14T10:57:26Z

[Term]
id: CL:0002308
name: epithelial cell of skin gland
def: "An epithelial cell of a skin gland." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "epithelial cell of gland of skin" EXACT []
xref: FMA:70657
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002419 ! part of skin gland
relationship: BFO:0000050 UBERON:0002419 ! part of skin gland
creation_date: 2010-09-14T12:00:07Z

[Term]
id: CL:0002312
name: somatotroph
def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl]
subset: human_subset
subset: mouse_subset
synonym: "somatotrope" EXACT []
synonym: "somatotropic cell" EXACT []
synonym: "somatrophic cell" EXACT []
xref: FMA:83095
xref: MESH:D052683
is_a: CL:0000295 ! somatotropin secreting cell
is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis
creation_date: 2010-09-14T02:33:09Z

[Term]
id: CL:0002319
name: neural cell
def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_subset
subset: mouse_subset
xref: CALOHA:TS-2040
xref: FMA:70333
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system
relationship: BFO:0000050 UBERON:0001016 ! part of nervous system
creation_date: 2010-09-15T01:34:57Z

[Term]
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest." [GOC:tfm, ISBN:0618947256, PMID:19198652, PMID:26043871, PMID:31194383]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_subset
subset: mouse_subset
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue
relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue
creation_date: 2010-09-15T03:01:54Z

[Term]
id: CL:0002321
name: embryonic cell (metazoa)
def: "A cell of the embryo." [FMA:0618947256]
subset: human_subset
subset: mouse_subset
xref: CALOHA:TS-0263
xref: FMA:82840
xref: WBbt:0007028
is_a: CL:0000000 ! cell
creation_date: 2010-09-15T03:39:21Z

[Term]
id: CL:0002328
name: bronchial epithelial cell
def: "An epithelial cell of the bronchus." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0002922
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus
relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus
creation_date: 2010-09-20T02:00:00Z

[Term]
id: CL:0002333
name: neural crest derived adipocyte
def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398]
subset: human_subset
subset: mouse_subset
is_a: CL:0000136 ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
relationship: RO:0002202 CL:0000005 ! develops from neural crest derived fibroblast
creation_date: 2010-09-20T02:25:25Z

[Term]
id: CL:0002350
name: endocardial cell
def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "endocardial endothelial cell" EXACT []
synonym: "endothelial cell of endocardium" EXACT [FMA:75621]
xref: FMA:75621
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium
relationship: BFO:0000050 UBERON:0002165 ! part of endocardium
creation_date: 2010-09-21T04:33:05Z

[Term]
id: CL:0002352
name: gestational hematopoietic stem cell
def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6]
subset: human_subset
subset: mouse_subset
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo
relationship: BFO:0000050 UBERON:0000922 ! part of embryo
creation_date: 2010-09-22T09:05:13Z

[Term]
id: CL:0002362
name: cerebellar granule cell precursor
def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [GOC:tfm, PMID:14745007]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "granule cell precursor" BROAD [doi:10.3389/fncir.2020.611841]
synonym: "granule cell progenitor" BROAD [doi:10.3389/fncir.2020.611841]
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
is_a: CL:0002319 ! neural cell
relationship: BFO:0000050 UBERON:0009841 ! part of upper rhombic lip
creation_date: 2010-09-22T01:40:44Z

[Term]
id: CL:0002363
name: keratocyte
def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "corneal fibroblast" EXACT []
synonym: "corneal keratocyte" EXACT []
is_a: CL:0000005 ! neural crest derived fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea
relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea
creation_date: 2010-09-22T01:57:40Z

[Term]
id: CL:0002368
name: respiratory tract epithelial cell
def: "An epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "airway epithelial cell" EXACT []
synonym: "respiratory epithelial cell" EXACT []
xref: BTO:0004533
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium
relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium
creation_date: 2010-09-23T04:38:49Z

[Term]
id: CL:0002369
name: fungal spore
def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm]
xref: MESH:D013172
is_a: CL:0000521 ! fungal cell
creation_date: 2010-10-01T09:02:42Z

[Term]
id: CL:0002372
name: myotube
def: "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "myofiber" EXACT [FBbt:00005812]
synonym: "myofibril" EXACT [FBbt:00005812]
is_a: CL:0000737 ! striated muscle cell
is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
intersection_of: RO:0000053 PATO:0002478 ! bearer of transversely striated
relationship: RO:0000053 PATO:0002478 ! bearer of transversely striated
creation_date: 2010-09-24T01:13:01Z

[Term]
id: CL:0002375
name: Schwann cell precursor
def: "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." [GOC:tfm, PMID:15580626, PMID:30971890, PMID:35815410]
comment: Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. {xref="PMID:35815410"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "Schwann cell precursor cell" EXACT []
is_a: CL:0011026 ! progenitor cell
relationship: RO:0000053 PATO:0001402 ! bearer of multipotent
relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
relationship: RO:0002387 CL:0002573 ! has potential to develop into Schwann cell
creation_date: 2010-09-24T02:06:10Z

[Term]
id: CL:0002377
name: immature Schwann cell
def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "Schwann cell" BROAD []
is_a: CL:0002573 ! Schwann cell
relationship: RO:0002202 CL:0002375 ! develops from Schwann cell precursor
creation_date: 2010-09-24T02:10:31Z

[Term]
id: CL:0002397
name: CD14-positive, CD16-positive monocyte
def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568]
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+).
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "CD16+ monocyte" EXACT [PMID:22343568]
is_a: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:0001054 ! CD14-positive monocyte
intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2
intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
relationship: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part C-C chemokine receptor type 2
relationship: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
creation_date: 2010-10-04T12:49:47Z

[Term]
id: CL:0002421
name: nucleated reticulocyte
def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052]
subset: human_subset
subset: mouse_subset
is_a: CL:0000558 ! reticulocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000558 ! reticulocyte
intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated
creation_date: 2010-10-15T09:24:05Z

[Term]
id: CL:0002453
name: oligodendrocyte precursor cell
def: "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2." [GOC:tfm, PMID:16367798, PMID:20142420, PMID:31583586, PMID:31726662, PMID:37653126]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "NG2 cell" RELATED [PMID:14501223]
synonym: "Polydendrocyte" RELATED [PMID:23516142]
xref: MESH:D000073637
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
relationship: BFO:0000050 CL:0000125 ! part of glial cell
relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system
relationship: RO:0002202 CL:0000047 ! develops from neural stem cell
relationship: RO:0002202 CL:0000339 ! develops from glioblast (sensu Vertebrata)
relationship: RO:0002203 CL:4023059 ! develops into committed oligodendrocyte precursor
creation_date: 2010-11-10T02:51:34Z

[Term]
id: CL:0002454
name: CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell
def: "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
synonym: "DC.8-4-11b+" EXACT []
synonym: "spleen double-negative dendritic cell" EXACT []
is_a: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:0002465 ! CD11b-positive dendritic cell
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
creation_date: 2010-11-22T01:10:28Z

[Term]
id: CL:0002462
name: adipose dendritic cell
def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0000990 ! conventional dendritic cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue
intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1
relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue
relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1
relationship: RO:0002202 CL:0002010 ! develops from pre-conventional dendritic cell
creation_date: 2010-11-23T01:38:21Z

[Term]
id: CL:0002463
name: SIRPa-positive adipose dendritic cell
def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
synonym: "DC.SIRPa+.Ad" EXACT []
is_a: CL:0002462 ! adipose dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1
relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1
creation_date: 2010-11-23T01:40:44Z

[Term]
id: CL:0002464
name: SIRPa-negative adipose dendritic cell
def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
synonym: "DC.SIRPa-.Ad" EXACT []
is_a: CL:0002462 ! adipose dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part tyrosine-protein phosphatase non-receptor type substrate 1
relationship: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part tyrosine-protein phosphatase non-receptor type substrate 1
creation_date: 2010-11-23T01:40:46Z

[Term]
id: CL:0002465
name: CD11b-positive dendritic cell
def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
is_a: CL:0000990 ! conventional dendritic cell
intersection_of: CL:0000990 ! conventional dendritic cell
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
relationship: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
creation_date: 2010-11-23T01:50:05Z

[Term]
id: CL:0002477
name: adipose macrophage
def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
intersection_of: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1
relationship: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
relationship: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
relationship: RO:0002104 PR:000001968 ! has plasma membrane part tyrosine-protein phosphatase non-receptor type substrate 1
creation_date: 2010-11-23T04:31:28Z

[Term]
id: CL:0002478
name: F4/80-negative adipose macrophage
def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
synonym: "MF.Autofl.Ad" EXACT []
is_a: CL:0002477 ! adipose macrophage
intersection_of: CL:0002477 ! adipose macrophage
intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1
intersection_of: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
relationship: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1
relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex
creation_date: 2010-11-23T04:40:50Z

[Term]
id: CL:0002479
name: F4/80-positive adipose macrophage
def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_subset
subset: mouse_subset
synonym: "MF.F480+.Ad" EXACT []
is_a: CL:0002477 ! adipose macrophage
intersection_of: CL:0002477 ! adipose macrophage
intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
relationship: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
relationship: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
creation_date: 2010-11-23T04:35:53Z

[Term]
id: CL:0002494
name: cardiocyte
def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm]
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.
subset: human_subset
subset: mouse_subset
synonym: "heart cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:83808
xref: FMA:84791
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ
relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ
creation_date: 2010-12-07T09:37:22Z

[Term]
id: CL:0002503
name: adventitial cell
def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0002441
xref: FMA:84639
is_a: CL:0000630 ! supporting cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: BFO:0000050 UBERON:0005742 ! part of adventitia
relationship: BFO:0000050 UBERON:0005742 ! part of adventitia
creation_date: 2010-12-07T04:03:56Z

[Term]
id: CL:0002521
name: subcutaneous adipocyte
def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "subcutaneous fat cell" EXACT []
is_a: CL:0000136 ! adipocyte
intersection_of: CL:0000136 ! adipocyte
intersection_of: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue
relationship: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue
creation_date: 2011-02-21T02:51:22Z

[Term]
id: CL:0002539
name: aortic smooth muscle cell
def: "A smooth muscle cell of the aorta." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0004577
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue
relationship: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue
creation_date: 2011-02-28T01:42:12Z

[Term]
id: CL:0002540
name: mesenchymal stem cell of the bone marrow
def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow
creation_date: 2011-02-28T01:47:47Z

[Term]
id: CL:0002543
name: vein endothelial cell
def: "An endothelial cell that is part of the vein." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "endothelial cell of vein" EXACT []
synonym: "venous endothelial cell" EXACT []
xref: FMA:62104
xref: KUPO:0001099
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0001638 ! part of vein
relationship: BFO:0000050 UBERON:0001638 ! part of vein
creation_date: 2011-02-28T03:48:11Z

[Term]
id: CL:0002547
name: fibroblast of the aortic adventitia
def: "A fibroblast of the aortic adventitia." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:1000306 ! fibroblast of tunica adventitia of artery
intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery
intersection_of: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia
relationship: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia
creation_date: 2011-02-28T04:43:41Z

[Term]
id: CL:0002548
name: fibroblast of cardiac tissue
def: "A fibroblast that is part of the heart." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cardiac fibroblast" EXACT []
is_a: CL:0000057 ! fibroblast
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000948 ! part of heart
relationship: BFO:0000050 UBERON:0000948 ! part of heart
creation_date: 2011-02-28T04:57:44Z

[Term]
id: CL:0002549
name: fibroblast of choroid plexus
def: "A fibroblast that is part of the choroid plexus." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus
relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus
creation_date: 2011-02-28T05:01:39Z

[Term]
id: CL:0002551
name: fibroblast of dermis
def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis
relationship: BFO:0000050 UBERON:0002067 ! part of dermis
creation_date: 2011-02-28T05:05:33Z

[Term]
id: CL:0002553
name: fibroblast of lung
def: "A fibroblast that is part of lung." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: BTO:0000764
xref: CALOHA:TS-0575
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000050 UBERON:0002048 ! part of lung
creation_date: 2011-02-28T05:11:03Z

[Term]
id: CL:0002557
name: fibroblast of pulmonary artery
def: "A fibroblast of pulmonary artery." [GOC:tfm]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery
relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery
creation_date: 2011-02-28T05:22:27Z

[Term]
id: CL:0002570
name: mesenchymal stem cell of adipose tissue
def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "mesenchymal stem cell of adipose" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue
relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue
creation_date: 2011-03-01T09:57:17Z

[Term]
id: CL:0002573
name: Schwann cell
def: "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." [GOC:tfm, PMID:16807057]
comment: A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle. {xref="PMID:16807057"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "neurolemmocyte" EXACT [PMID:32119275, PMID:38638689]
xref: BTO:0001220
xref: CALOHA:TS-0898
xref: MESH:D012583
is_a: CL:0000125 ! glial cell
relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system
creation_date: 2011-03-02T01:19:27Z

[Term]
id: CL:0002585
name: retinal blood vessel endothelial cell
def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0000966 ! part of retina
relationship: BFO:0000050 UBERON:0000966 ! part of retina
creation_date: 2011-03-06T03:28:27Z

[Term]
id: CL:0002589
name: smooth muscle cell of the brachiocephalic vasculature
def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery
relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery
creation_date: 2011-03-06T05:00:58Z

[Term]
id: CL:0002590
name: smooth muscle cell of the brain vasculature
def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0000955 ! part of brain
relationship: BFO:0000050 UBERON:0000955 ! part of brain
creation_date: 2011-03-06T05:01:20Z

[Term]
id: CL:0002591
name: smooth muscle cell of the pulmonary artery
def: "A smooth muscle of the pulmonary artery." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0003336
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery
relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery
creation_date: 2011-03-06T05:01:28Z

[Term]
id: CL:0002595
name: smooth muscle cell of the subclavian artery
def: "A smooth muscle cell of the subclavian artery." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery
relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery
creation_date: 2011-03-06T05:01:52Z

[Term]
id: CL:0002596
name: smooth muscle cell of the carotid artery
def: "Smooth muscle cell of the carotid artery." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment
relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment
creation_date: 2011-03-06T05:01:56Z

[Term]
id: CL:0002598
name: bronchial smooth muscle cell
def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0004402
is_a: CL:0019019 ! tracheobronchial smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus
relationship: BFO:0000050 UBERON:0002185 ! part of bronchus
creation_date: 2011-03-06T05:46:39Z

[Term]
id: CL:0002599
name: smooth muscle cell of the esophagus
def: "A smooth muscle cell of the esophagus." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus
relationship: BFO:0000050 UBERON:0001043 ! part of esophagus
creation_date: 2011-03-06T05:48:17Z

[Term]
id: CL:0002600
name: smooth muscle cell of trachea
def: "A smooth muscle cell of the trachea." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0019019 ! tracheobronchial smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea
relationship: BFO:0000050 UBERON:0003126 ! part of trachea
creation_date: 2011-03-06T05:50:28Z

[Term]
id: CL:0002603
name: astrocyte of the cerebellum
def: "An astrocyte of the cerebellum." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000127 ! astrocyte
is_a: CL:2000005 ! brain macroglial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0002037 ! part of cerebellum
relationship: BFO:0000050 UBERON:0002037 ! part of cerebellum
creation_date: 2011-03-06T06:57:27Z

[Term]
id: CL:0002605
name: astrocyte of the cerebral cortex
def: "A transcriptomically distinct astrocyte that is found in the cerebral cortex." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0012000 ! astrocyte of the forebrain
is_a: CL:1001579 ! cerebral cortex glial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex
creation_date: 2011-03-06T06:57:36Z

[Term]
id: CL:0002606
name: astrocyte of the spinal cord
def: "An astrocyte of the spinal cord." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0000127 ! astrocyte
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord
relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord
creation_date: 2011-03-06T07:11:26Z

[Term]
id: CL:0002610
name: raphe nuclei neuron
def: "A neuron of the raphe nuclei." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei
relationship: RO:0002100 UBERON:0004684 ! has soma location raphe nuclei
creation_date: 2011-03-06T07:42:06Z

[Term]
id: CL:0002612
name: neuron of the ventral spinal cord
def: "A neuron of the ventral spinal cord." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord
relationship: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spinal cord
creation_date: 2011-03-06T07:46:03Z

[Term]
id: CL:0002613
name: striatum neuron
def: "A neuron of the striatum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002435 ! has soma location striatum
relationship: RO:0002100 UBERON:0002435 ! has soma location striatum
creation_date: 2011-03-06T07:47:12Z

[Term]
id: CL:0002620
name: skin fibroblast
def: "A fibroblast of skin." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: BTO:0001255
xref: CALOHA:TS-0935
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body
relationship: BFO:0000050 UBERON:0002097 ! part of skin of body
creation_date: 2011-03-14T12:31:49Z

[Term]
id: CL:0002632
name: epithelial cell of lower respiratory tract
def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0002368 ! respiratory tract epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium
relationship: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium
creation_date: 2011-06-21T12:29:31Z

[Term]
id: CL:0002653
name: squamous endothelial cell
def: "A squamous shaped endothelial cell." [GOC:dos]
subset: human_subset
subset: mouse_subset
is_a: CL:0000115 ! endothelial cell
creation_date: 2011-07-08T03:31:25Z

[Term]
id: CL:0002657
name: glandular cell of esophagus
def: "A glandular epithelial cell of the esophagus." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: FMA:86548
is_a: CL:0000150 ! glandular secretory epithelial cell
is_a: CL:0002252 ! epithelial cell of esophagus
intersection_of: CL:0000150 ! glandular secretory epithelial cell
intersection_of: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus
creation_date: 2011-07-08T03:55:57Z

[Term]
id: CL:0002663
name: myocardial endocrine cell of atrium
def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:83389
is_a: CL:0002074 ! myocardial endocrine cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium
relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium
creation_date: 2011-07-11T02:45:39Z

[Term]
id: CL:0002664
name: cardioblast
def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164]
comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.
subset: human_subset
subset: mouse_subset
synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164]
is_a: CL:0000048 ! multi fate stem cell
creation_date: 2011-07-11T03:15:38Z

[Term]
id: CL:0002672
name: retinal progenitor cell
def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000048 ! multi fate stem cell
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell
creation_date: 2011-08-16T02:38:01Z

[Term]
id: CL:0002673
name: tongue muscle cell
def: "A skeletal muscle cell that is part of the tongue." [GOC:tfm, PMID:18816858]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: BFO:0000050 UBERON:0000378 ! part of tongue muscle
relationship: BFO:0000050 UBERON:0000378 ! part of tongue muscle
creation_date: 2011-08-16T03:10:02Z

[Term]
id: CL:0002676
name: neural crest derived neuroblast
def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019]
subset: human_subset
subset: mouse_subset
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
creation_date: 2011-08-22T09:24:15Z

[Term]
id: CL:0005000
name: spinal cord interneuron
def: "A CNS interneuron located in the spinal cord." [CL:CVS]
comment: Is_a interneuron, part_of UBERON:0002240.
subset: human_subset
subset: mouse_subset
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord
relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord

[Term]
id: CL:0005024
name: somatomotor neuron
def: "A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic." [ZFIN:CVS]
subset: human_subset
subset: mouse_subset
synonym: "somatic motor neuron" EXACT []
is_a: CL:0000100 ! motor neuron
is_a: CL:0000108 ! cholinergic neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber
relationship: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber

[Term]
id: CL:0007001
name: skeletogenic cell
def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034]
comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)
subset: human_subset
subset: mouse_subset
synonym: "scleroblast" EXACT [GO_REF:0000034]
is_a: CL:0000000 ! cell
creation_date: 2012-06-15T02:51:27Z

[Term]
id: CL:0007004
name: premigratory neural crest cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0011012 ! neural crest cell
relationship: BFO:0000050 UBERON:0002342 ! part of neural crest
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell
creation_date: 2012-06-27T08:27:35Z

[Term]
id: CL:0007009
name: prechondroblast
def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034]
subset: human_subset
subset: mouse_subset
is_a: CL:0011026 ! progenitor cell
creation_date: 2012-06-27T10:44:01Z

[Term]
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
subset: human_subset
subset: mouse_subset
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0008001
name: hematopoietic precursor cell
def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000988 ! hematopoietic cell

[Term]
id: CL:0008002
name: skeletal muscle fiber
def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: MESH:D018485
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0002372 ! myotube
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue
intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
intersection_of: RO:0000053 PATO:0002478 ! bearer of transversely striated
relationship: RO:0002202 CL:0000515 ! develops from skeletal muscle myoblast

[Term]
id: CL:0008007
name: visceral muscle cell
def: "A muscle cell that is part of some visceral muscle." [GOC:dos]
subset: human_subset
subset: mouse_subset
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue
relationship: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue

[Term]
id: CL:0008008
name: striated visceral muscle cell
def: "A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods." [GOC:dos]
subset: human_subset
subset: mouse_subset
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! bearer of striated

[Term]
id: CL:0008009
name: transversely striated visceral muscle cell
def: "A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods." [GOC:dos]
subset: human_subset
subset: mouse_subset
is_a: CL:0008008 ! striated visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! bearer of transversely striated
relationship: RO:0000053 PATO:0002478 ! bearer of transversely striated

[Term]
id: CL:0008017
name: adult skeletal muscle myoblast
def: "A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905]
comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "myogenic precursor cell" BROAD [PMID:23303905]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue
intersection_of: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber

[Term]
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: BFO:0000050 UBERON:0003104 ! part of mesenchyme
relationship: RO:0002215 GO:0016477 ! capable of cell migration

[Term]
id: CL:0008022
name: endocardial cushion cell
def: "A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864]
subset: human_subset
subset: mouse_subset
is_a: CL:0000569 ! cardiac mesenchymal cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000569 ! cardiac mesenchymal cell
intersection_of: BFO:0000050 UBERON:0002062 ! part of endocardial cushion
relationship: BFO:0000050 UBERON:0002062 ! part of endocardial cushion

[Term]
id: CL:0008025
name: noradrenergic neuron
def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos]
subset: human_subset
subset: mouse_subset
is_a: CL:0000459 ! noradrenergic cell
is_a: CL:4033050 ! catecholaminergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission
relationship: RO:0002215 GO:0061533 ! capable of norepinephrine secretion, neurotransmission

[Term]
id: CL:0008028
name: visual system neuron
def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002216 GO:0007601 ! capable of part of visual perception
relationship: RO:0002216 GO:0007601 ! capable of part of visual perception
creation_date: 2017-07-09T19:12:36Z

[Term]
id: CL:0008031
name: cortical interneuron
def: "An interneuron that has its soma located in the cerebral cortex." []
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cerebral cortex interneuron" EXACT []
is_a: CL:0000099 ! interneuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex

[Term]
id: CL:0008034
name: mural cell
def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194]
subset: added_for_HCA
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:4033054 ! perivascular cell
creation_date: 2020-02-29T17:33:55Z

[Term]
id: CL:0008035
name: microcirculation associated smooth muscle cell
def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0008034 ! mural cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel
relationship: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel
creation_date: 2020-02-29T17:37:00Z

[Term]
id: CL:0008042
name: tanycyte of subfornical organ
def: "A tanycyte of the subfornical organ (SFO).  These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SFO, where they form a dense network surrounding these capillaries." [PMID:23649873]
subset: human_subset
subset: mouse_subset
synonym: "tanycyte-like cell of subfornical organ" EXACT [PMID:23649873]
is_a: CL:0002085 ! tanycyte
intersection_of: CL:0002085 ! tanycyte
intersection_of: BFO:0000050 UBERON:0002219 ! part of subfornical organ
relationship: BFO:0000050 UBERON:0002219 ! part of subfornical organ

[Term]
id: CL:0008045
name: tanycyte of subcommissural organ
def: "A tanycyte of the subcommisural organ (SCO).  These cells extend long and slender fibers extending from their cell bodies in the ependyma toward fenestrated capillaries associated with the SCO, where they form a dense network surrounding these capillaries." [PMID:23649873]
subset: human_subset
subset: mouse_subset
synonym: "tanycyte-like cell of subcommissural organ" EXACT [PMID:23649873]
is_a: CL:0002085 ! tanycyte
intersection_of: CL:0002085 ! tanycyte
intersection_of: BFO:0000050 UBERON:0002139 ! part of subcommissural organ
relationship: BFO:0000050 UBERON:0002139 ! part of subcommissural organ

[Term]
id: CL:0008053
name: circumventricular organ capillary endothelial cell
def: "A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans." [PMID:26578857, PMID:35726097]
subset: human_subset
subset: mouse_subset
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000044 ! brain microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: BFO:0000050 UBERON:0005408 ! part of circumventricular organ
relationship: BFO:0000050 UBERON:0005408 ! part of circumventricular organ

[Term]
id: CL:0008055
name: respiratory tract secretory epithelial cell
def: "A secretory epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin." [DOI:10.1038/s41591-023-02327-2.]
subset: human_subset
subset: mouse_subset
is_a: CL:0002368 ! respiratory tract epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium

[Term]
id: CL:0008059
name: GABA-Gly neuron
def: "A neuron that releases both gamma-aminobutyric acid and glycine as vesicular neurotransmitters.  Examples include types of amacrine cell and types of cerebellar inhibitory neurons." [PMID:18677503, PMID:37124720]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:1001509 ! glycinergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission

[Term]
id: CL:0008060
name: GABA-Glut neuron
def: "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters." [PMID:29924991, PMID:37124720, PMID:38092916]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0000679 ! glutamatergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:0008061
name: GABA-Chol neuron
def: "A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters.  Examples include some types of striatal interneuron." [PMID:29651049]
subset: human_subset
subset: mouse_subset
is_a: CL:0000108 ! cholinergic neuron
is_a: CL:0000617 ! GABAergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0014055 ! capable of acetylcholine secretion, neurotransmission
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission

[Term]
id: CL:0009000
name: sensory neuron of spinal nerve
def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr]
subset: human_subset
subset: mouse_subset
synonym: "spinal sensory neuron" EXACT []
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve
relationship: RO:0002100 UBERON:0001780 ! has soma location spinal nerve

[Term]
id: CL:0009001
name: compound eye retinal cell
def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." []
xref: GOC:pr
xref: PMID:12021768
is_a: CL:0009004 ! retinal cell

[Term]
id: CL:0009004
name: retinal cell
def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: PMID:10702418
is_a: CL:0002319 ! neural cell
intersection_of: CL:0002319 ! neural cell
intersection_of: BFO:0000050 UBERON:0005388 ! part of photoreceptor array
relationship: BFO:0000050 UBERON:0005388 ! part of photoreceptor array

[Term]
id: CL:0009097
name: embryonic skeletal muscle fiber
def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501]
subset: human_subset
subset: mouse_subset
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage
relationship: RO:0002491 UBERON:0000068 ! existence starts and ends during embryo stage

[Term]
id: CL:0010001
name: stromal cell of bone marrow
def: "A stromal cell that is part_of a bone marrow." []
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "bone marrow stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow

[Term]
id: CL:0010004
name: mononuclear cell of bone marrow
def: "A mononuclear cell that is part_of a bone marrow." []
subset: human_subset
subset: mouse_subset
synonym: "bone marrow mononuclear cell" EXACT []
is_a: CL:0000842 ! mononuclear leukocyte
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000842 ! mononuclear leukocyte
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow

[Term]
id: CL:0010006
name: cardiac blood vessel endothelial cell
def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0000948 ! part of heart

[Term]
id: CL:0010007
name: His-Purkinje system cell
def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system
relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system

[Term]
id: CL:0010008
name: cardiac endothelial cell
def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000948 ! part of heart
relationship: BFO:0000050 UBERON:0000948 ! part of heart

[Term]
id: CL:0010009
name: camera-type eye photoreceptor cell
def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
synonym: "camera type eye photoreceptor cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye
relationship: BFO:0000050 UBERON:0000966 ! part of retina

[Term]
id: CL:0010010
name: cerebellar stellate cell
def: "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling." [PMID:31110133, PMID:5042759]
subset: human_subset
subset: mouse_subset
is_a: CL:0000691 ! stellate interneuron
is_a: CL:4042035 ! molecular layer interneuron
intersection_of: CL:0000122 ! stellate neuron
intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex

[Term]
id: CL:0010011
name: cerebral cortex GABAergic interneuron
def: "A GABAergic interneuron whose soma is located in the cerebral cortex." [GOC:dos]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0008031 ! cortical interneuron
is_a: CL:0011005 ! GABAergic interneuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex

[Term]
id: CL:0010012
name: cerebral cortex neuron
def: "A CNS neuron of the cerebral cortex." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "cortical neuron" EXACT []
synonym: "neuron of cerebral cortex" EXACT []
xref: BTO:0004102
xref: FMA:84104
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex

[Term]
id: CL:0010017
name: zygote
def: "A zygote in a plant or an animal." []
subset: human_subset
subset: mouse_subset
xref: MESH:D015053
is_a: CL:0000000 ! cell

[Term]
id: CL:0010020
name: cardiac glial cell
def: "Any glial cell that is part of some heart." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
is_a: CL:0000125 ! glial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0000948 ! part of heart
relationship: BFO:0000050 UBERON:0000948 ! part of heart

[Term]
id: CL:0010021
name: cardiac myoblast
def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated]
subset: human_subset
subset: mouse_subset
xref: MESH:D032386
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: RO:0002203 CL:0000746 ! develops into cardiac muscle cell
relationship: RO:0002203 CL:0000746 ! develops into cardiac muscle cell

[Term]
id: CL:0010022
name: cardiac neuron
def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764]
comment: This term is used in 3 GO terms that were created as part of the heart development focus project.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart
relationship: RO:0002100 UBERON:0000948 ! has soma location heart

[Term]
id: CL:0011001
name: spinal cord motor neuron
def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000100 ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord
relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord

[Term]
id: CL:0011005
name: GABAergic interneuron
def: "An interneuron that uses GABA as a vesicular neurotransmitter.  These interneurons are inhibitory" [GOC:CellBLAST, GOC:nv, PMID:29724907]
comment: The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges.
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "GABAergic inhibitory interneuron" EXACT []
is_a: CL:0000498 ! inhibitory interneuron
is_a: CL:0000617 ! GABAergic neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission

[Term]
id: CL:0011006
name: Lugaro cell
def: "A cerebellar interneuron characterized by a spindle-shaped or triangular soma, parasagittally oriented and located at the border between the granular layer and the Purkinje cell layer. The Lugaro cell extends dendrites predominantly in the parasagittal plane, forming synaptic interactions with basket, stellate, and Golgi cells. Its axonal projections extend upward into the molecular layer, where they form a parasagittal plexus and emit long transverse collaterals that run parallel to the long axis of the cerebellar folia. The Lugaro cell is capable of co-releasing GABA and glycine, as evidenced by the expression of glutamate decarboxylase (GAD65/67) and the glycine transporter GlyT2." [GOC:nv, PMID:18677503, PMID:2273099]
subset: human_subset
subset: mouse_subset
synonym: "globular cell" RELATED [PMID:34194302]
is_a: CL:0008059 ! GABA-Gly neuron
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
relationship: RO:0002100 UBERON:0002956 ! has soma location granular layer of cerebellar cortex

[Term]
id: CL:0011007
name: paraxial cell
def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "paraxial mesoderm cell" EXACT []
synonym: "presomitic mesoderm cell" NARROW []
synonym: "somitic mesoderm cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
intersection_of: CL:0000222 ! mesodermal cell
intersection_of: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm
relationship: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm

[Term]
id: CL:0011012
name: neural crest cell
def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002321 ! embryonic cell (metazoa)

[Term]
id: CL:0011019
name: mesothelial cell of epicardium
def: "A mesothelial cell that is part of the epicardium." []
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002348 ! part of epicardium
relationship: BFO:0000050 UBERON:0002348 ! part of epicardium

[Term]
id: CL:0011021
name: fibroblast of upper back skin
def: "A fibroblast that is part of upper back skin." []
subset: human_subset
subset: mouse_subset
is_a: CL:0011022 ! fibroblast of skin of back
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0009015 ! part of upper back skin
relationship: BFO:0000050 UBERON:0009015 ! part of upper back skin

[Term]
id: CL:0011022
name: fibroblast of skin of back
def: "A fibroblast that is part of skin of back." []
subset: human_subset
subset: mouse_subset
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001068 ! part of skin of back
relationship: BFO:0000050 UBERON:0001068 ! part of skin of back

[Term]
id: CL:0011026
name: progenitor cell
def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: RO:0002202 CL:0000034 ! develops from stem cell
relationship: RO:0002202 CL:0000034 ! develops from stem cell

[Term]
id: CL:0011027
name: skeletal muscle fibroblast
def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "skeleton muscle fibroblast" EXACT []
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:1001609 ! muscle fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue

[Term]
id: CL:0011028
name: olfactory ensheathing cell
def: "A neural-crest derived glial cell that supports the growth and survival of primary olfactory neuroons from the neuroepithelium in the nasal cavity to the brain by encasing large bundles of numerous unmyelinated axons." [PMID:22456085]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "OEC" EXACT []
xref: BTO:0002771
is_a: CL:0000125 ! glial cell

[Term]
id: CL:0011030
name: dermal microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity]
subset: human_subset
subset: mouse_subset
synonym: "dermal microvascular endothelium cell" EXACT []
synonym: "DMEC cell" EXACT []
is_a: CL:2000008 ! microvascular endothelial cell
is_a: CL:2000010 ! dermis blood vessel endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis

[Term]
id: CL:0011111
name: hypothalamic gonadotropin-releasing hormone neuron
def: "a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation." [GOC:NV, PMID:20807514, PMID:21828096, PMID:26053743, PMID:34128468, PMID:35067985]
subset: human_subset
subset: mouse_subset
synonym: "GnRH neuron" EXACT []
synonym: "GnRH-secreting neuron" EXACT []
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0012001 ! neuron of the forebrain
relationship: RO:0002596 GO:0032274 ! capable of regulating gonadotropin secretion

[Term]
id: CL:0011115
name: precursor cell
def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos]
comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0030154 ! capable of cell differentiation
relationship: RO:0002215 GO:0030154 ! capable of cell differentiation

[Term]
id: CL:0012000
name: astrocyte of the forebrain
def: "An astrocyte of the forebrain." []
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "forebrain astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte
is_a: CL:2000005 ! brain macroglial cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain
relationship: BFO:0000050 UBERON:0001890 ! part of forebrain

[Term]
id: CL:0012001
name: neuron of the forebrain
def: "A CNS neuron of the forebrain." []
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "forebrain neuron" EXACT []
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001890 ! has soma location forebrain
relationship: RO:0002100 UBERON:0001890 ! has soma location forebrain

[Term]
id: CL:0013000
name: forebrain radial glial cell
def: "Any radial glial cell that is part of some forebrain." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain
relationship: BFO:0000050 UBERON:0001890 ! part of forebrain

[Term]
id: CL:0017500
name: neutrophillic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0070046 ! bearer of neutrophillic
relationship: RO:0000053 PATO:0070046 ! bearer of neutrophillic
creation_date: 2010-05-25T01:36:34Z

[Term]
id: CL:0017502
name: acidophilic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add]
synonym: "eosinophilic" NARROW []
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0002418 ! bearer of acidophilic
relationship: RO:0000053 PATO:0002418 ! bearer of acidophilic
creation_date: 2009-12-22T04:23:25Z

[Term]
id: CL:0017503
name: basophilic cytoplasm
def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0002094 ! bearer of basophilic
relationship: RO:0000053 PATO:0002094 ! bearer of basophilic
creation_date: 2009-12-22T04:24:54Z

[Term]
id: CL:0017504
name: polychromatophilic cytoplasm
def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: RO:0000053 PATO:0070047 ! bearer of polychromatophilic
relationship: RO:0000053 PATO:0070047 ! bearer of polychromatophilic
creation_date: 2009-12-28T04:25:23Z

[Term]
id: CL:0019001
name: tracheobronchial serous cell
def: "Any serous secreting cell that is part of the tracheobronchial epithelium." []
subset: added_for_HCA
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "serous cell of tracheobronchial tree" EXACT []
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000313 ! serous secreting cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree
relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree

[Term]
id: CL:0019002
name: tracheobronchial chondrocyte
def: "Any chondrocyte that is part of the tracheobronchial tree." []
subset: added_for_HCA
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "chondrocyte of tracheobronchial tree" EXACT []
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree
relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree

[Term]
id: CL:0019018
name: blood vessel smooth muscle cell
def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "smooth muscle cell of blood vessel" EXACT []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel
relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel

[Term]
id: CL:0019019
name: tracheobronchial smooth muscle cell
def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867]
comment: The marker set ACTA2, TAGLN can identify the Human cell type tracheobronchial smooth muscle cell in the lung with a confidence of 0.69 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "smooth muscle cell of tracheobronchial tree" EXACT []
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree
relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree
relationship: RO:0015004 CLM:1000056 ! has characterizing marker set NS forest marker set of tracheobronchial smooth muscle cell (Human lung).

[Term]
id: CL:0020003
name: internal globus pallidus core projecting neuron
def: "A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi) of primates, in the central “core” region. It expresses parvalbumin, is primarily GABAergic, and projects to motor thalamic nuclei including the ventral anterior, ventrolateral, and ventromedial nuclei. In the rodent homolog (entopeduncular nucleus), the core subregion is characterized by concentrated parvalbumin-positive neurons targeting the ventral anterior-ventral lateral thalamic nucleus and receives inputs from the dorsolateral striatum innervated by sensorimotor cortices (Miyamoto & Fukuda, 2022). This neuron corresponds to the sensorimotor output population of the GPi, as demonstrated in human tissue and cross-species comparative studies (Wallace et al., 2017) and by classic tracing in primates (Parent & De Bellefeuille, 1982; Parent et al., 2001)." [PMID:11596046, PMID:28384468, PMID:28949036, PMID:35927027, PMID:7127069]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0012001 ! neuron of the forebrain
relationship: RO:0002100 UBERON:0002477 ! has soma location medial globus pallidus
relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha

[Term]
id: CL:0020004
name: internal globus pallidus shell projection neuron
def: "A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi), in the peripheral 'shell' region. In mice and primates, it expresses somatostatin and shows dual expression of GABAergic and glutamatergic markers, enabling co-release of GABA and glutamate (Wallace et al., 2017). It projects primarily to the lateral habenula (Parent & De Bellefeuille, 1982; Wallace et al., 2017), forming the limbic/aversive output stream of the GPi." [doi:10.1101/2022.03.16.484460, PMID:11596046, PMID:28384468, PMID:30755721, PMID:33787995, PMID:7127069]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0012001 ! neuron of the forebrain
relationship: RO:0002100 UBERON:0002477 ! has soma location medial globus pallidus
relationship: RO:0002292 PR:000015665 ! expresses somatostatin
creation_date: 2025-09-30T14:21:41Z

[Term]
id: CL:0020006
name: OB-Dopa-GABA
def: "A transcriptomically defined GABAergic neuron coexpressing dopamine located in the olfactory bulb and part of the striatum." [PMID:35322231]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0000700 ! dopaminergic neuron
is_a: CL:0002613 ! striatum neuron

[Term]
id: CL:0020007
name: dorso-striatal cholinergic-GABAergic neuron
def: "A transcriptomically defined GABAergic neuron in the dorsal striatum. In mice and primates, it is defined by the coexpression of choline acetyltransferase (ChAT) together with the GABAergic markers glutamate decarboxylase 65 (GAD65/Gad2) and vesicular GABA transporter (VGAT/Slc32a1) (Lozovaya et al., 2018)." [PMID:10934256, PMID:19855026, PMID:29651049, PMID:37464873]
subset: human_subset
subset: mouse_subset
is_a: CL:0002613 ! striatum neuron
is_a: CL:0008061 ! GABA-Chol neuron
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:0020008
name: striatal cholinergic-GABAergic neuron
def: "A large aspiny interneuron of the striatum that serves as the principal intrinsic source of acetylcholine while simultaneously releasing GABA. It is defined by coexpression of cholinergic markers (ChAT and VAChT/Slc18a3) and GABAergic markers (GAD65/Gad2 and VGAT/Slc32a1) (Lozovaya et al., 2018). This MGE-derived neuron maintains Lhx6 expression associated with dual-transmitter identity (Fragkouli et al., 2009; Marin et al., 2000). Morphologically, it possesses a large soma (20–50 μm diameter), 2–4 thick aspiny dendrites extending radially ~1 mm, and locally ramified axons with hundreds of thousands of varicosities (Wilson et al., 1990; Lim et al., 2014)." [PMID:10377365, PMID:10934256, PMID:21925242, PMID:2329464, PMID:25374536, PMID:25876458, PMID:29651049, PMID:37905876]
subset: human_subset
subset: mouse_subset
is_a: CL:0002613 ! striatum neuron
is_a: CL:0008061 ! GABA-Chol neuron
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:0020009
name: prototypic neuron
def: "A GABAergic neuron located in the external globus pallidus (GPe) that constitutes approximately two-thirds of all GPe neurons (Mallet et al., 2012, Dodson et al., 2015). Derived from the medial ganglionic eminence, this cell selectively expresses Nkx2-1, with roughly two-thirds co-expressing parvalbumin (PV) and one-third lacking it in mice (Mallet et al., 2012; Dodson et al., 2015)." [doi:10.1101/2022.03.16.484460, PMID:22726837, PMID:25843402, PMID:25926446, PMID:27194328, PMID:37336974]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0012001 ! neuron of the forebrain
relationship: RO:0002100 UBERON:0002476 ! has soma location lateral globus pallidus
relationship: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence
relationship: RO:0002292 PR:000011241 ! expresses homeobox protein Nkx-2.1
creation_date: 2025-10-17T09:12:54Z

[Term]
id: CL:0020010
name: arkypallidal neuron
def: "A GABAergic projection neuron located in the external segment of the globus pallidus (GPe) and defined by its exclusive projection to the dorsal striatum rather than to the subthalamic nucleus or basal ganglia output nuclei. In rodents and primates, it is characterized molecularly by expression of FOXP2, MEIS2, and NPAS1, and lacks expression of canonical pallidal markers NKX2-1 and LHX6 (Dodson et al., 2015; Abdi et al., 2015; Courtney et al., 2023). This neuron is GABAergic (GAD1/2⁺, SLC32A1/VGAT⁺) and typically PV⁻, forming the transcriptionally and developmentally LGE-derived subclass of GPe neurons (Dodson et al., 2015; Mallet et al., 2012)." [PMID:22726837, PMID:25843402, PMID:25926446, PMID:27194328, PMID:37336974]
subset: human_subset
subset: mouse_subset
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0012001 ! neuron of the forebrain
is_a: CL:4023035 ! lateral ganglionic eminence derived neuron
relationship: RO:0002100 UBERON:0002476 ! has soma location lateral globus pallidus
creation_date: 2025-10-16T10:21:41Z

[Term]
id: CL:1000042
name: forebrain neuroblast
def: "Any neuroblast (sensu Vertebrata) that is part of some forebrain." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata)
intersection_of: BFO:0000050 UBERON:0001890 ! part of forebrain
relationship: BFO:0000050 UBERON:0001890 ! part of forebrain

[Term]
id: CL:1000073
name: spinal cord radial glial cell
def: "Any radial glial cell that is part of some spinal cord." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000681 ! radial glial cell
intersection_of: CL:0000681 ! radial glial cell
intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord
relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord

[Term]
id: CL:1000223
name: pulmonary neuroendocrine cell
def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253]
comment: The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "lung neuroendocrine cell" EXACT [PMID:15018448]
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000051 GO:0031045 ! has part dense core granule
relationship: RO:0002215 GO:0070483 ! capable of detection of hypoxia
relationship: RO:0015004 CLM:1000043 ! has characterizing marker set NS forest marker set of pulmonary neuroendocrine cell (Human lung).

[Term]
id: CL:1000272
name: lung secretory cell
def: "Any secretory cell that is part of some lung." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000050 UBERON:0002048 ! part of lung

[Term]
id: CL:1000274
name: trophectodermal cell
def: "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange." [PMID:22918806]
subset: human_subset
subset: mouse_subset
synonym: "trophectoderm cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell
intersection_of: CL:0000349 ! extraembryonic cell
intersection_of: BFO:0000050 UBERON:0004345 ! part of trophectoderm
relationship: BFO:0000050 UBERON:0004345 ! part of trophectoderm
relationship: RO:0002203 CL:0000351 ! develops into trophoblast cell

[Term]
id: CL:1000298
name: mesothelial cell of dura mater
def: "A mesothelial cell that is part of the dura mater." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "squamous mesothelial cell of dura mater" EXACT [FMA:256516]
xref: FMA:256516
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002363 ! part of dura mater
relationship: BFO:0000050 UBERON:0002363 ! part of dura mater

[Term]
id: CL:1000303
name: fibroblast of areolar connective tissue
def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:261279
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue
relationship: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue

[Term]
id: CL:1000306
name: fibroblast of tunica adventitia of artery
def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:261285
is_a: CL:4052030 ! adventitial fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0007240 ! part of tunica adventitia of artery
relationship: BFO:0000050 UBERON:0007240 ! part of tunica adventitia of artery

[Term]
id: CL:1000307
name: fibroblast of dense regular elastic tissue
def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:261287
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue
relationship: BFO:0000050 UBERON:0002521 ! part of elastic tissue
relationship: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue

[Term]
id: CL:1000309
name: epicardial adipocyte
def: "An adipocyte that is part of the epicardial fat." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "adipocyte of epicardial fat" EXACT [FMA:261293]
synonym: "epicardial fat cell" EXACT [FMA:261293]
xref: FMA:261293
is_a: CL:0000136 ! adipocyte
is_a: CL:0002494 ! cardiocyte
relationship: BFO:0000050 UBERON:0002348 ! part of epicardium

[Term]
id: CL:1000310
name: adipocyte of epicardial fat of right ventricle
def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297]
synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297]
xref: FMA:261297
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle
relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle

[Term]
id: CL:1000311
name: adipocyte of epicardial fat of left ventricle
def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300]
synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300]
xref: FMA:261300
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle
relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle

[Term]
id: CL:1000330
name: serous cell of epithelium of trachea
def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:263078
is_a: CL:0019001 ! tracheobronchial serous cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea
relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea

[Term]
id: CL:1000331
name: serous cell of epithelium of bronchus
def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:263080
is_a: CL:0019001 ! tracheobronchial serous cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus
relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus

[Term]
id: CL:1000361
name: transitional myocyte of interatrial septum
def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:263152
is_a: CL:0002073 ! transitional myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: BFO:0000050 UBERON:0002085 ! part of interatrial septum
relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum

[Term]
id: CL:1000362
name: transitional myocyte of interventricular septum
def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:263154
is_a: CL:0002073 ! transitional myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum
relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum

[Term]
id: CL:1000376
name: Purkinje myocyte of interventricular septum
def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:263182
is_a: CL:0002068 ! Purkinje myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum
relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum

[Term]
id: CL:1000409
name: myocyte of sinoatrial node
def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "SA nodal myocyte" EXACT [FMA:67102]
synonym: "SA node cardiac muscle cell" EXACT [GOC:pr]
synonym: "sinoatrial node cell" EXACT [GOC:pr]
synonym: "sinoatrial node myocyte" EXACT []
synonym: "sinuatrial node myocyte" EXACT [FMA:67102]
xref: FMA:67102
is_a: CL:0002072 ! nodal myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node
relationship: BFO:0000050 UBERON:0002351 ! part of sinoatrial node

[Term]
id: CL:1000410
name: myocyte of atrioventricular node
def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "atrioventricular node cell" EXACT [GOC:pr]
synonym: "atrioventricular node myocyte" EXACT [FMA:67106]
synonym: "AV nodal myocyte" EXACT [FMA:67106]
synonym: "AV node cardiac muscle cell" EXACT [GOC:pr]
synonym: "AV node cell" EXACT [GOC:pr]
xref: FMA:67106
is_a: CL:0002072 ! nodal myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node
relationship: BFO:0000050 UBERON:0002352 ! part of atrioventricular node

[Term]
id: CL:1000412
name: endothelial cell of arteriole
def: "An endothelial cell that is part of the arteriole." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:67760
xref: KUPO:0001097
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole
relationship: BFO:0000050 UBERON:0001980 ! part of arteriole

[Term]
id: CL:1000413
name: endothelial cell of artery
def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "arterial endothelial cell" EXACT []
xref: BTO:0004758
xref: FMA:67761
xref: KUPO:0001095
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001637 ! part of artery
relationship: BFO:0000050 UBERON:0001917 ! part of endothelium of artery

[Term]
id: CL:1000414
name: endothelial cell of venule
def: "An endothelial cell that is part of the venule." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:67762
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: BFO:0000050 UBERON:0001979 ! part of venule
relationship: BFO:0000050 UBERON:0001979 ! part of venule

[Term]
id: CL:1000428
name: stem cell of epidermis
def: "A somatic stem cell that is part of the epidermis." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "epidermal stem cell" EXACT [FMA:70541]
xref: FMA:70541
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis
relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis

[Term]
id: CL:1000443
name: ciliary muscle cell
def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_subset
subset: mouse_subset
synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610]
xref: FMA:70610
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body
relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body

[Term]
id: CL:1000444
name: mesothelial cell of anterior chamber of eye
def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:70615
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball
relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball

[Term]
id: CL:1000456
name: mesothelial cell of parietal peritoneum
def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:72142
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum
relationship: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum

[Term]
id: CL:1000457
name: mesothelial cell of visceral peritoneum
def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:72143
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum
relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum

[Term]
id: CL:1000465
name: chromaffin cell of ovary
def: "A chromaffin cell that is part of the ovary." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:74319
is_a: CL:0000166 ! chromaffin cell
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary
relationship: BFO:0000050 UBERON:0000992 ! part of ovary

[Term]
id: CL:1000466
name: chromaffin cell of right ovary
def: "A chromaffin cell that is part of the right ovary." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:74320
is_a: CL:1000465 ! chromaffin cell of ovary
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0002118 ! part of right ovary
relationship: BFO:0000050 UBERON:0002118 ! part of right ovary

[Term]
id: CL:1000467
name: chromaffin cell of left ovary
def: "A chromaffin cell that is part of the left ovary." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:74321
is_a: CL:1000465 ! chromaffin cell of ovary
intersection_of: CL:0000166 ! chromaffin cell
intersection_of: BFO:0000050 UBERON:0002119 ! part of left ovary
relationship: BFO:0000050 UBERON:0002119 ! part of left ovary

[Term]
id: CL:1000478
name: transitional myocyte of sinoatrial node
def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "transitinal myocyte of sinuatrial node" EXACT []
xref: FMA:83384
is_a: CL:0002073 ! transitional myocyte
is_a: CL:1000409 ! myocyte of sinoatrial node
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node

[Term]
id: CL:1000479
name: Purkinje myocyte of atrioventricular node
def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:83386
is_a: CL:0002068 ! Purkinje myocyte
is_a: CL:1000410 ! myocyte of atrioventricular node
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node

[Term]
id: CL:1000482
name: myocardial endocrine cell of interventricular septum
def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:83390
is_a: CL:0002074 ! myocardial endocrine cell
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum
relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum

[Term]
id: CL:1000490
name: mesothelial cell of peritoneum
def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm]
subset: human_subset
subset: mouse_subset
synonym: "peritoneal mesothelial cell" EXACT [FMA:86736]
xref: FMA:86736
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum
relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum

[Term]
id: CL:1000491
name: mesothelial cell of pleura
def: "A mesothelial cell that is part of the pleura." [GOC:tfm]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "pleural mesothelial cell" EXACT [FMA:86737]
xref: FMA:86737
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura
relationship: BFO:0000050 UBERON:0000977 ! part of pleura

[Term]
id: CL:1000492
name: mesothelial cell of parietal pleura
def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm]
subset: human_subset
subset: mouse_subset
xref: FMA:86738
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002400 ! part of parietal pleura
relationship: BFO:0000050 UBERON:0002400 ! part of parietal pleura

[Term]
id: CL:1000493
name: mesothelial cell of visceral pleura
def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: FMA:86739
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: BFO:0000050 UBERON:0002401 ! part of visceral pleura
relationship: BFO:0000050 UBERON:0002401 ! part of visceral pleura

[Term]
id: CL:1001474
name: medium spiny neuron
def: "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus." [doi:10.1073/pnas.242428599, MP:0008462]
comment: Direct genetic lineage tracing in mice, including Dlx-based and Sp9-Cre fate mapping, demonstrates that medium spiny neurons (MSNs) originate from progenitors in the lateral ganglionic eminence (LGE), with labeled cells migrating from LGE to the striatum and expressing MSN markers such as FOXP1 and CTIP2. {xref="doi:10.1523/JNEUROSCI.20-16-06063.2000", xref="doi:10.1038/s41420-022-01088-0"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "gamma-aminobutyric acid (GABA)ergic spiny projection neuron" EXACT [doi:10.1073/pnas.242428599]
synonym: "gamma-aminobutyric acid ergic spiny projection neuron" EXACT [doi:10.1073/pnas.242428599]
synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778]
synonym: "striatal medium spiny neuron" EXACT [GO:0021773]
xref: BTO:0004778
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:4023035 ! lateral ganglionic eminence derived neuron
relationship: RO:0002100 UBERON:0000369 ! has soma location corpus striatum

[Term]
id: CL:1001509
name: glycinergic neuron
def: "The neurons that utilize glycine as a neurotransmitter." [MP:0010385]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission
relationship: RO:0002215 GO:0061537 ! capable of glycine secretion, neurotransmission

[Term]
id: CL:1001567
name: lung endothelial cell
def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "endothelial cell of lung" RELATED []
synonym: "pulmonary vessel endothelial cell" RELATED []
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000050 UBERON:0000102 ! part of lung vasculature

[Term]
id: CL:1001568
name: pulmonary artery endothelial cell
def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "PAEC cell" RELATED [BTO:0001141]
xref: BTO:0001141
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery
relationship: BFO:0000050 UBERON:0005317 ! part of pulmonary artery endothelium

[Term]
id: CL:1001576
name: oral mucosa squamous cell
def: "Squamous cell of oral epithelium." [NPX:PDR]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252]
synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252]
xref: CALOHA:TS-1252
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: BFO:0000050 UBERON:0002424 ! part of oral epithelium
relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium

[Term]
id: CL:1001579
name: cerebral cortex glial cell
def: "Glial cell of cerebral cortex." [NPX:PDR]
subset: human_subset
subset: mouse_subset
synonym: "brain cortex glial cell" RELATED [CALOHA:TS-1256]
synonym: "cerebral cortex glial cells" RELATED [CALOHA:TS-1256]
synonym: "cerebrum cortex glial cell" RELATED [CALOHA:TS-1256]
xref: CALOHA:TS-1256
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex
relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex

[Term]
id: CL:1001581
name: lateral ventricle glial cell
def: "Glial cell of lateral ventricle." [NPX:PDR]
subset: human_subset
subset: mouse_subset
synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258]
xref: CALOHA:TS-1258
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle
relationship: BFO:0000050 UBERON:0002285 ! part of telencephalic ventricle

[Term]
id: CL:1001582
name: lateral ventricle neuron
def: "Neuron of lateral ventricle." [NPX:PDR]
subset: human_subset
subset: mouse_subset
synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261]
xref: CALOHA:TS-1261
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle
relationship: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle

[Term]
id: CL:1001602
name: cerebral cortex endothelial cell
def: "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." [NPX:PDR]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372]
synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372]
xref: CALOHA:TS-2372
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000956 ! part of cerebral cortex
relationship: BFO:0000050 UBERON:0000956 ! part of cerebral cortex
relationship: BFO:0000050 UBERON:0013694 ! part of brain endothelium

[Term]
id: CL:1001603
name: lung macrophage
def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [HPA:HPA, NPX:PDR]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "lung macrophages" RELATED [CALOHA:TS-0576]
xref: CALOHA:TS-0576
is_a: CL:0000235 ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000050 UBERON:0002048 ! part of lung

[Term]
id: CL:1001609
name: muscle fibroblast
def: "Fibroblast from muscle organ." [NPX:PDR]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
xref: CALOHA:TS-0643
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ
relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ

[Term]
id: CL:1001610
name: bone marrow hematopoietic cell
def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR]
subset: human_subset
subset: mouse_subset
synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109]
synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109]
xref: CALOHA:TS-2109
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow
relationship: BFO:0000050 UBERON:0012429 ! part of hematopoietic tissue

[Term]
id: CL:1001611
name: cerebellar neuron
def: "Neuron of the cerebellum." [NPX:PDR]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359]
xref: CALOHA:TS-2359
xref: FMA:84665
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum

[Term]
id: CL:1100001
name: secretory epithelial cell
def: "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." [https://orcid.org/0000-0002-7073-9172]
subset: human_subset
subset: mouse_subset
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: CL:0000151 ! secretory cell

[Term]
id: CL:2000001
name: peripheral blood mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000080 ! circulating cell
is_a: CL:0000842 ! mononuclear leukocyte
intersection_of: CL:0000842 ! mononuclear leukocyte
intersection_of: BFO:0000050 UBERON:0000178 ! part of blood
relationship: BFO:0000050 UBERON:0000178 ! part of blood
creation_date: 2014-02-11T17:29:04Z

[Term]
id: CL:2000004
name: pituitary gland cell
def: "Any cell that is part of a pituitary gland." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000007 ! part of pituitary gland
relationship: BFO:0000050 UBERON:0000007 ! part of pituitary gland
creation_date: 2014-03-26T22:14:56Z

[Term]
id: CL:2000005
name: brain macroglial cell
def: "Any macroglial cell that is part of a brain." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0000126 ! macroglial cell
intersection_of: CL:0000126 ! macroglial cell
intersection_of: BFO:0000050 UBERON:0000955 ! part of brain
relationship: BFO:0000050 UBERON:0000955 ! part of brain
creation_date: 2014-03-28T21:35:27Z

[Term]
id: CL:2000008
name: microvascular endothelial cell
def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium
relationship: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium
creation_date: 2014-06-04T15:07:42Z

[Term]
id: CL:2000010
name: dermis blood vessel endothelial cell
def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis
relationship: BFO:0000050 UBERON:0002067 ! part of dermis
creation_date: 2014-06-04T15:12:06Z

[Term]
id: CL:2000013
name: fibroblast of skin of abdomen
def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: BFO:0000050 UBERON:0001416 ! part of skin of abdomen
relationship: BFO:0000050 UBERON:0001416 ! part of skin of abdomen
creation_date: 2014-06-04T15:18:16Z

[Term]
id: CL:2000016
name: lung microvascular endothelial cell
def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:1001567 ! lung endothelial cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:1001567 ! lung endothelial cell
intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium
creation_date: 2014-06-04T16:00:56Z

[Term]
id: CL:2000019
name: compound eye photoreceptor cell
def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie]
is_a: CL:0000287 ! eye photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000018 ! part of compound eye
relationship: BFO:0000050 UBERON:0000018 ! part of compound eye
creation_date: 2014-06-24T23:16:45Z

[Term]
id: CL:2000020
name: inner cell mass cell
def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000087 ! part of inner cell mass
relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass
creation_date: 2014-06-24T23:16:53Z

[Term]
id: CL:2000022
name: cardiac septum cell
def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum
relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum
creation_date: 2014-06-24T23:17:07Z

[Term]
id: CL:2000025
name: spinal cord oligodendrocyte
def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0000128 ! oligodendrocyte
intersection_of: CL:0000128 ! oligodendrocyte
intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord
relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord
creation_date: 2014-06-25T00:23:50Z

[Term]
id: CL:2000027
name: cerebellar basket cell
def: "A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions." [PMID:32990595, PMID:8915580]
subset: human_subset
subset: mouse_subset
synonym: "cerebellum basket cell" EXACT []
is_a: CL:0000118 ! basket cell
is_a: CL:4042035 ! molecular layer interneuron
intersection_of: CL:0000118 ! basket cell
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
creation_date: 2014-06-25T00:24:03Z

[Term]
id: CL:2000028
name: cerebellum glutamatergic neuron
def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0000679 ! glutamatergic neuron
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
creation_date: 2014-06-25T00:24:10Z

[Term]
id: CL:2000029
name: central nervous system neuron
def: "Any neuron that is part of a central nervous system." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0001017 ! has soma location central nervous system
relationship: RO:0002100 UBERON:0001017 ! has soma location central nervous system
creation_date: 2014-06-25T01:17:43Z

[Term]
id: CL:2000030
name: hypothalamus cell
def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001898 ! part of hypothalamus
relationship: BFO:0000050 UBERON:0001898 ! part of hypothalamus
creation_date: 2014-06-25T01:17:50Z

[Term]
id: CL:2000032
name: peripheral nervous system neuron
def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "peripheral neuron" EXACT []
synonym: "PNS neuron" EXACT []
xref: FMA:84664
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
creation_date: 2014-06-25T02:28:17Z

[Term]
id: CL:2000042
name: embryonic fibroblast
def: "Any fibroblast that is part of a embryo." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo
relationship: BFO:0000050 UBERON:0000922 ! part of embryo
creation_date: 2014-07-09T00:12:00Z

[Term]
id: CL:2000044
name: brain microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0002319 ! neural cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: BFO:0000050 UBERON:0000955 ! part of brain
relationship: BFO:0000050 UBERON:0000955 ! part of brain
creation_date: 2014-07-09T00:24:53Z

[Term]
id: CL:2000046
name: ventricular cardiac muscle cell
def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle
relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle
creation_date: 2014-08-12T20:50:28Z

[Term]
id: CL:2000047
name: brainstem motor neuron
def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000100 ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: RO:0002100 UBERON:0002298 ! has soma location brainstem
relationship: RO:0002100 UBERON:0002298 ! has soma location brainstem
creation_date: 2014-10-02T23:52:53Z

[Term]
id: CL:2000063
name: ovarian fibroblast
def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
is_a: CL:0002132 ! stromal cell of ovary
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary
creation_date: 2014-10-07T17:57:42Z

[Term]
id: CL:2000066
name: cardiac ventricle fibroblast
def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle
relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle
creation_date: 2014-10-07T18:35:38Z

[Term]
id: CL:2000067
name: cardiac atrium fibroblast
def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium
relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium
creation_date: 2014-10-07T18:36:54Z

[Term]
id: CL:2000068
name: pericardium fibroblast
def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium
relationship: BFO:0000050 UBERON:0002407 ! part of pericardium
creation_date: 2014-10-07T18:38:06Z

[Term]
id: CL:2000070
name: optic choroid fibroblast
def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620
subset: human_subset
subset: mouse_subset
is_a: CL:0000005 ! neural crest derived fibroblast
is_a: CL:0000348 ! choroidal cell of the eye
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid
creation_date: 2014-10-07T18:50:43Z

[Term]
id: CL:2000072
name: adipose microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200
subset: human_subset
subset: mouse_subset
is_a: CL:0002320 ! connective tissue cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue
relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue
creation_date: 2014-10-07T22:13:45Z

[Term]
id: CL:2000073
name: migratory cardiac neural crest cell
def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
synonym: "cardiac neural crest cell" EXACT [PMID:33060096]
is_a: CL:0000333 ! migratory neural crest cell
intersection_of: CL:0000333 ! migratory neural crest cell
intersection_of: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest
relationship: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest
creation_date: 2014-11-05T01:18:43Z

[Term]
id: CL:2000080
name: mesenchymal stem cell of abdominal adipose tissue
def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
synonym: "mesenchymal stem cell of abdominal adipose" EXACT []
is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen
relationship: BFO:0000050 UBERON:0000916 ! part of abdomen
creation_date: 2014-12-02T19:10:34Z

[Term]
id: CL:2000086
name: neocortex basket cell
def: "Any basket cell that is part of a neocortex." [GOC:TermGenie]
subset: human_subset
subset: mouse_subset
is_a: CL:0000118 ! basket cell
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
intersection_of: CL:0000118 ! basket cell
intersection_of: RO:0002100 UBERON:0001950 ! has soma location neocortex
relationship: RO:0002100 UBERON:0001950 ! has soma location neocortex
creation_date: 2014-12-24T00:37:19Z

[Term]
id: CL:2000093
name: bronchus fibroblast of lung
def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0002553 ! fibroblast of lung
intersection_of: CL:0002553 ! fibroblast of lung
intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus
relationship: BFO:0000050 UBERON:0002185 ! part of bronchus
creation_date: 2015-03-31T21:16:22Z

[Term]
id: CL:2000097
name: midbrain dopaminergic neuron
def: "Any dopaminergic neuron that is part of a midbrain." [GOC:TermGenie]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000700 ! dopaminergic neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000700 ! dopaminergic neuron
intersection_of: RO:0002100 UBERON:0001891 ! has soma location midbrain
relationship: RO:0002100 UBERON:0001891 ! has soma location midbrain
creation_date: 2015-12-03T16:42:40Z

[Term]
id: CL:3000004
name: peripheral sensory neuron
def: "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing." [GOC:CellBLAST, https://www.britannica.com/science/sensory-neuron, https://www.ncbi.nlm.nih.gov/books/NBK539846/, PMID:30096314, PMID:31554486, PMID:35858549, Wikipedia:Sensory_neuron]
comment: Typically, a sensory neuron has a pseudounipolar morphology. {xref="Wikipedia:Sensory_neuron"}
subset: human_subset
subset: mouse_subset
is_a: CL:0000101 ! sensory neuron
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception
creation_date: 2019-02-25T19:34:33Z

[Term]
id: CL:4023011
name: lamp5 GABAergic interneuron
def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:30382198, PMID:37824655]
comment: The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic interneuron in the neocortex with a confidence of 0.814687838 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: BDS_subset
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
xref: ILX:0770149
is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002292 PR:000032148 ! expresses lysosome-associated membrane glycoprotein 5
relationship: RO:0002292 PR:000032148 ! expresses lysosome-associated membrane glycoprotein 5
relationship: RO:0015004 CLM:1000074 ! has characterizing marker set NS forest marker set of lamp5 GABAergic interneuron (Human neocortex).

[Term]
id: CL:4023016
name: VIP GABAergic interneuron
def: "A transcriptomically distinct GABAergic neuron derived from the CGE and that expresses the vasoactive intestinal polypeptide. Its soma is located in the forebrain." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:33186530, PMID:37824655]
comment: The marker set VIP can identify the Human cell type VIP GABAergic interneuron in the neocortex with a confidence of 0.855531344 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: BDS_subset
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "Vip" RELATED [ILX:0770151]
synonym: "Vip GABAergic neuron" BROAD [ILX:0770151]
synonym: "VIP interneuron" BROAD [PMID:33108272]
synonym: "VIP neuron" BROAD [PMID:33108272]
synonym: "VIP neuron" RELATED [PMID:36384143]
synonym: "VIP type" RELATED [PMID:37824655]
synonym: "VIP-Expressing GABAergic Neuron" BROAD [PMID:35221922]
synonym: "VIP-IN" RELATED [PMID:33794534]
xref: ILX:0770151
is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002292 PR:000017299 ! expresses VIP peptides
relationship: RO:0002292 PR:000017299 ! expresses VIP peptides
relationship: RO:0015004 CLM:1000085 ! has characterizing marker set NS forest marker set of VIP GABAergic interneuron (Human neocortex).

[Term]
id: CL:4023017
name: sst GABAergic interneuron
def: "A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst) and derived from the MGE." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:27477017, PMID:33742131, PMID:37824655]
comment: The marker set SST, PLCH1 can identify the Human cell type sst GABAergic interneuron in the neocortex with a confidence of 0.842367005 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: BDS_subset
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "SOM+ inhibitory interneuron" RELATED [PMID:30001424]
synonym: "somatostatin-expressing inhibitory interneuron" RELATED [PMID:30001424]
synonym: "SST+ IN" RELATED [PMID:33742131]
xref: ILX:0770152
is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron
intersection_of: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002292 PR:000015665 ! expresses somatostatin
relationship: RO:0002292 PR:000015665 ! expresses somatostatin
relationship: RO:0015004 CLM:1000082 ! has characterizing marker set NS forest marker set of sst GABAergic interneuron (Human neocortex).

[Term]
id: CL:4023026
name: direct pathway medium spiny neuron
def: "A GABAergic medium spiny neuron located in the striatum that gives rise to the direct basal ganglia pathway. It projects directly to the GPi and SNr, where it inhibits tonically active GABAergic output neurons to disinhibit thalamic and brainstem motor targets (Gerfen. 2023). In mice and humans, this cell selectively expresses the D1 dopamine receptor (DRD1), which couples to stimulatory G-proteins (Gs/Gαolf) to increase cAMP and activate PKA-dependent signaling cascades (Gerfen et al., 1990; Kebabian & Calne, 1979). Functionally, activation of this cell promotes selected motor actions by disinhibiting thalamic and midbrain motor centers (Mink, 1996; Cui et al., 2013)." [PMID:2147780, PMID:215920, PMID:23354054, PMID:34727523, PMID:36741471, PMID:9004351, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850]
comment: Despite the direct and indirect circuits are often described not only as functionally opposing but also as anatomically segregated there are several anatomical and functional studies that have challenged this notion of pure segregation based on extensive collateral projections between pathways, dual-projection neurons, simultaneous co-activation during behavior. {xref="PMID:29737578", xref="PMID:26018615"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "dopamine 1 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596]
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor

[Term]
id: CL:4023029
name: indirect pathway medium spiny neuron
def: "A GABAergic medium spiny neuron located in the striatum that gives rise to the indirect basal ganglia pathway. It projects to the GPe, where its axon typically ramifies in two regions but does not extend beyond this nucleus (Gerfen et al., 2022). It selectively expresses the D2 dopamine receptor (DRD2), which couples to inhibitory G-proteins (Gi/o) to decrease cAMP and suppress PKA-mediated signaling (Gerfen et al., 2022). Morphologically, this cell displays fewer and shorter dendrites than the MSN-D1 and receives fewer glutamatergic inputs, yet it exhibits significantly higher intrinsic excitability (Gertler et al., 2022). Functionally, activation of this cell suppresses competing or alternative motor actions by inhibiting GPe neurons, leading through STN and other GPe circuits to increased GPi/SNr output and stronger inhibition of thalamic and brainstem targets (Mink, 1996; Tecuapetla et al., 2016)." [PMID:27453468, PMID:34727523, PMID:36741471, PMID:9004351, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850]
comment: Despite the direct and indirect circuits are often described not only as functionally opposing but also as anatomically segregated there are several anatomical and functional studies that have challenged this notion of pure segregation based on extensive collateral projections between pathways, dual-projection neurons, simultaneous co-activation during behavior. {xref="PMID:29737578", xref="PMID:26018615"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "dopamine 2 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596]
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor

[Term]
id: CL:4023035
name: lateral ganglionic eminence derived neuron
def: "A neuron that is derived from a precursor cell in the lateral ganglion eminence." [wikipediaversioned:Ganglionic_eminence&oldid=1186824360]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "LGE-derived neuron" EXACT [PMID:10377350]
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002202 UBERON:0004025 ! develops from lateral ganglionic eminence
relationship: RO:0002202 UBERON:0004025 ! develops from lateral ganglionic eminence

[Term]
id: CL:4023051
name: vascular leptomeningeal cell
def: "A transcriptomically distinct type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Non-neuronal cells', Author Categories: 'CrossArea_subclass', clusters VLMC." [https://cellxgene.cziscience.com/e/5346f9c6-755e-4336-94cc-38706ec00c2f.cxg/, PMID:27284195, PMID:29443965, PMID:30096314, PMID:37824655]
subset: BDS_subset
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "VLMC" EXACT []
xref: ILX:0770143
is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx
relationship: RO:0002202 CL:0011012 ! develops from neural crest cell

[Term]
id: CL:4023054
name: mesothelial fibroblast
def: "A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell." [PMID:26106328]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
relationship: RO:0002202 CL:0000077 ! develops from mesothelial cell

[Term]
id: CL:4023057
name: cerebellar inhibitory GABAergic interneuron
def: "A GABAergic interneuron whose soma is located in the cerebellar cortex." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0011005 ! GABAergic interneuron
is_a: CL:1001611 ! cerebellar neuron
intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex
relationship: RO:0002100 UBERON:0002129 ! has soma location cerebellar cortex

[Term]
id: CL:4023058
name: mesothelial fibroblast of the leptomeninx
def: "A mesothelial fibroblast found in the leptomeninx." []
subset: human_subset
subset: mouse_subset
is_a: CL:0002319 ! neural cell
is_a: CL:4023054 ! mesothelial fibroblast
intersection_of: CL:4023054 ! mesothelial fibroblast
intersection_of: BFO:0000050 UBERON:0000391 ! part of leptomeninx
relationship: BFO:0000050 UBERON:0000391 ! part of leptomeninx

[Term]
id: CL:4023059
name: committed oligodendrocyte precursor
def: "An oligodendrocyte precursor cell that is committed to differentiate." [PMID:32066987]
comment: COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from. {xref="PMID:27284195"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "differentiation-committed oligodendrocyte precursor" EXACT []
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
relationship: RO:0002202 CL:0002453 ! develops from oligodendrocyte precursor cell

[Term]
id: CL:4023063
name: medial ganglionic eminence derived interneuron
def: "An interneuron that is derived from the medial ganglionic eminence." [DOI:10.1101/2022.10.12.511898]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "MGE interneuron" EXACT []
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence
relationship: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence

[Term]
id: CL:4023064
name: caudal ganglionic eminence derived interneuron
def: "An interneuron that is derived from the caudal ganglionic eminence." [PMID:20130169, PMID:37824655, PMID:37824663]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "caudal ganglionic eminence derived GABAergic interneuron" EXACT [PMID:20130169]
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
is_a: CL:4042039 ! caudal ganglionic eminence derived neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002202 UBERON:0004026 ! develops from caudal ganglionic eminence

[Term]
id: CL:4023068
name: thalamic excitatory neuron
def: "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response." [PMID:30083593, PMID:31196673, PMID:35278647, PMID:37163009, PMID:37824663, PMID:38739251]
comment: Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease. {xref="PMID:11532718", xref="PMID:30083593", xref="PMID:38739251"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0012001 ! neuron of the forebrain
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0010225 ! has soma location thalamic complex
intersection_of: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotransmission
relationship: RO:0002100 UBERON:0010225 ! has soma location thalamic complex

[Term]
id: CL:4023069
name: medial ganglionic eminence derived GABAergic interneuron
def: "A GABAergic interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex." [PMID:12637172]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
is_a: CL:4023063 ! medial ganglionic eminence derived interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminence
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission

[Term]
id: CL:4023072
name: brain vascular cell
def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0008998 ! part of vasculature of brain
relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain

[Term]
id: CL:4023079
name: midbrain-derived inhibitory neuron
def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:2000029 ! central nervous system neuron
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002202 UBERON:0001891 ! develops from midbrain
relationship: RO:0002202 UBERON:0001891 ! develops from midbrain

[Term]
id: CL:4023097
name: arachnoid barrier cell
def: "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." [PMID:23298861]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx
relationship: BFO:0000050 UBERON:0000437 ! part of arachnoid barrier layer

[Term]
id: CL:4023111
name: cerebral cortex pyramidal neuron
def: "A pyramidal neuron with soma located in the cerebral cortex." [PMID:30715238]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:0010012 ! cerebral cortex neuron
intersection_of: CL:0000598 ! pyramidal neuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex

[Term]
id: CL:4023121
name: sst chodl GABAergic interneuron
def: "A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection." [https://cellxgene.cziscience.com/e/9c63201d-bfd9-41a8-bbbc-18d947556f3d.cxg/, PMID:15845086, PMID:31209381, PMID:33372656, PMID:37824655]
comment: The marker set NPY can identify the Human cell type sst chodl GABAergic interneuron in the neocortex with a confidence of 0.894026187 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "long-range GABAergic interneuron" BROAD [PMID:33372656]
is_a: CL:4023017 ! sst GABAergic interneuron
relationship: RO:0002292 PR:000005444 ! expresses chondrolectin
relationship: RO:0015004 CLM:1000083 ! has characterizing marker set NS forest marker set of sst chodl GABAergic interneuron (Human neocortex).

[Term]
id: CL:4023154
name: myelinating glial cell
def: "A glial cell that myelinates axonal processes." [DOI:10.1007/3-540-29623-9_3240]
subset: human_subset
subset: mouse_subset
is_a: CL:0000125 ! glial cell
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000051 GO:0043209 ! has part myelin sheath
relationship: BFO:0000051 GO:0043209 ! has part myelin sheath

[Term]
id: CL:4023161
name: unipolar brush cell
def: "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." [PMID:9193142, WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "neuronal brush cell" EXACT []
is_a: CL:0000099 ! interneuron
is_a: CL:0000679 ! glutamatergic neuron
relationship: BFO:0000051 GO:0044293 ! has part dendriole
relationship: RO:0000053 PATO:0070025 ! bearer of unipolar neuron morphology
relationship: RO:0002100 UBERON:0002028 ! has soma location hindbrain

[Term]
id: CL:4023168
name: somatosensory neuron
def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660]
subset: human_subset
subset: mouse_subset
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: BFO:0000050 UBERON:0003942 ! part of somatosensory system
intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system
relationship: BFO:0000050 UBERON:0003942 ! part of somatosensory system

[Term]
id: CL:4023181
name: hypendymal cell
def: "A neurecto-epithelial cell that is part of the basal layer of the subcommissural organ and specializes in the secretion of proteins into the subarachnoid space. Hypendymal cells have similar characteristics to ependymal cells and express SCO-spondin." [https://orcid.org/0000-0001-7258-9596, PMID:26778959, PMID:9579598]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:0002319 ! neural cell
relationship: BFO:0000050 UBERON:0002139 ! part of subcommissural organ
relationship: RO:0002292 PR:000015658 ! expresses SCO-spondin

[Term]
id: CL:4028001
name: pulmonary capillary endothelial cell
def: "Any capillary endothelial cell that is part of a lung." []
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
synonym: "lung capillary endothelial cell" EXACT []
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000016 ! lung microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000050 UBERON:0016405 ! part of pulmonary capillary
creation_date: 2021-11-23T02:31:40Z

[Term]
id: CL:4030029
name: blood lymphocyte
def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331]
subset: blood_and_immune_upper_slim
subset: human_subset
subset: mouse_subset
is_a: CL:0000542 ! lymphocyte
is_a: CL:2000001 ! peripheral blood mononuclear cell
intersection_of: CL:0000542 ! lymphocyte
intersection_of: BFO:0000050 UBERON:0000178 ! part of blood

[Term]
id: CL:4030043
name: matrix D1 medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002613 ! striatum neuron
is_a: CL:4023026 ! direct pathway medium spiny neuron

[Term]
id: CL:4030047
name: matrix D2 medium spiny neuron
def: "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002613 ! striatum neuron
is_a: CL:4023029 ! indirect pathway medium spiny neuron

[Term]
id: CL:4030048
name: striosomal D1 medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "striosome D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
is_a: CL:0002613 ! striatum neuron
is_a: CL:4023026 ! direct pathway medium spiny neuron

[Term]
id: CL:4030049
name: striosomal D2 medium spiny neuron
def: "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "striosome D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
is_a: CL:0002613 ! striatum neuron
is_a: CL:4023029 ! indirect pathway medium spiny neuron

[Term]
id: CL:4030051
name: nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "NAc shell and OT D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
is_a: CL:0002613 ! striatum neuron
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor

[Term]
id: CL:4030052
name: nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron
def: "A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "NAc shell and OT D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
is_a: CL:0002613 ! striatum neuron
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum
relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor

[Term]
id: CL:4030053
name: Islands of Calleja granule cell
def: "A GABAergic neuron that resides in the islands of calleja and shows the cytoarchitectural and molecular features characteristic of this granule-like cell population. In mice and primates, it expresses D1 and D3 dopamine receptors (Drd1; Drd3), GABAergic markers (GAD1/2) and form densely packed granule cell clusters in the olfactory tubercle within the ventral striatum. Moreover it receives dense dopaminergic input from the VTA, and functionally associated with self-grooming behaviors and depression-like behaviors." [doi:10.1016/j.cub.2021.10.015, PMID:34795450, PMID:37898623]
comment: In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4. {xref="doi:10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
is_a: CL:0000120 ! granule cell
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0002613 ! striatum neuron
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor

[Term]
id: CL:4030054
name: D1-NUDAP medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei." [PMID:34727523]
comment: Regarding the abbreviation D1-NUDAP, NUDAP stands for "neurochemically unique domains in the accumbens and putamen". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions. {xref="PMID:34727523"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "RXFP1-positive interface island D1-medium spiny neuron" EXACT [PMID:34727523]
is_a: CL:0002613 ! striatum neuron
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor
relationship: RO:0002292 PR:000001666 ! expresses relaxin receptor 1

[Term]
id: CL:4033008
name: vein endothelial cell of respiratory system
def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0002543 ! vein endothelial cell
intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system
relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system

[Term]
id: CL:4033015
name: retinal astrocyte
def: "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons." [PMID:25236977, PMID:33796062]
comment: In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive. {xref="PMID:33796062", xref="PMID:32555229"}
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_subset
subset: mouse_subset
is_a: CL:0000127 ! astrocyte
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000127 ! astrocyte
intersection_of: BFO:0000050 UBERON:0000966 ! part of retina
relationship: BFO:0000050 UBERON:0000966 ! part of retina

[Term]
id: CL:4033018
name: lung megakaryocyte
def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "lung resident megakaryocyte" EXACT [PMID:36524131]
synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131]
is_a: CL:0000556 ! megakaryocyte
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: BFO:0000050 UBERON:0000114 ! part of lung connective tissue
relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue

[Term]
id: CL:4033049
name: taste receptor cell of tongue
def: "A taste receptor cell that is part of a taste bud of a tongue." [DOI:10.1111/j.1096-3642.1981.tb01137.x, http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf, PMID:10052456, PMID:28655883]
subset: human_subset
subset: mouse_subset
synonym: "gustatory cell of tongue" RELATED [DOI:10.1016/s0022-5320(69)80043-2]
is_a: CL:0000209 ! taste receptor cell
is_a: CL:0002319 ! neural cell
intersection_of: CL:0000209 ! taste receptor cell
intersection_of: BFO:0000050 UBERON:0014451 ! part of tongue taste bud
relationship: BFO:0000050 UBERON:0014451 ! part of tongue taste bud

[Term]
id: CL:4033050
name: catecholaminergic neuron
def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209]
comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002215 GO:0160043 ! capable of catecholamine secretion, neurotransmission
relationship: RO:0002215 GO:0160043 ! capable of catecholamine secretion, neurotransmission

[Term]
id: CL:4033054
name: perivascular cell
def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329]
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002220 UBERON:0002049 ! adjacent to vasculature
relationship: RO:0002220 UBERON:0002049 ! adjacent to vasculature

[Term]
id: CL:4033093
name: limbal epithelial stem cell of cornea
def: "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023)." [PMID:20614614, PMID:29105366, PMID:36983561, PMID:37768272]
subset: human_subset
subset: mouse_subset
synonym: "limbal epithelial stem cell" EXACT [PMID:20614614]
synonym: "limbal stem cell" EXACT [PMID:17562792]
is_a: CL:0000036 ! epithelial fate stem cell
intersection_of: CL:0000034 ! stem cell
intersection_of: BFO:0000050 UBERON:0006761 ! part of corneo-scleral junction
relationship: BFO:0000050 UBERON:0000482 ! part of basal lamina of epithelium
relationship: BFO:0000050 UBERON:0006761 ! part of corneo-scleral junction
relationship: RO:0002203 CL:0000575 ! develops into corneal epithelial cell

[Term]
id: CL:4040004
name: mesenchymal stem cell of orbital adipose tissue
def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473]
subset: human_subset
subset: mouse_subset
synonym: "OAMSC" EXACT [PMID:31377878]
synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878]
synonym: "Orbital ASCs" EXACT [PMID:30210548]
is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region
relationship: BFO:0000050 UBERON:0004088 ! part of orbital region

[Term]
id: CL:4042001
name: TAC3-positive striatal interneuron
def: "A GABAergic interneuron that has its soma located in the striatum and that has an enriched expression of the genes TAC3 and LHX6." [PMID:32999462, PMID:34727523]
subset: cellxgene_subset
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "TAC3 interneuron" EXACT [PMID:34727523]
is_a: CL:0002613 ! striatum neuron
is_a: CL:0011005 ! GABAergic interneuron
relationship: RO:0002104 PR:000016004 ! has plasma membrane part tachykinin-3

[Term]
id: CL:4042003
name: border associated macrophage
def: "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier." [PMID:37232741, PMID:37626977]
comment: In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169. {xref="PMID:29426702", xref="PMID:37232741"}
subset: human_subset
subset: mouse_subset
synonym: "CNS-associated macrophage" RELATED [PMID:37232741]
is_a: CL:0000878 ! central nervous system macrophage

[Term]
id: CL:4042013
name: Lamp5 Lhx6 neuron
def: "A transcriptomically distinct GABAergic interneuron marked by Lamp5 and Lhx6 expression, derived from the Medial Ganglionic Eminence (MGE), and located in the pallium." [https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/, PMID:34004146, PMID:36007006, PMID:37824655, PMID:37824669]
comment: The marker set CHST9, LAMP5 can identify the Human cell type Lamp5 Lhx6 neuron in the neocortex with a confidence of 0.821678322 (NS-Forest FBeta value). {xref="https://doi.org/10.5281/zenodo.11165918"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "Ivy cell" EXACT [PMID:36007006]
synonym: "Lamp5-Lhx6 type" EXACT [PMID:30382198]
is_a: CL:4023011 ! lamp5 GABAergic interneuron
is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic interneuron
relationship: RO:0002292 PR:000032533 ! expresses LIM/homeobox protein Lhx6
relationship: RO:0015004 CLM:1000075 ! has characterizing marker set NS forest marker set of Lamp5 Lhx6 neuron (Human neocortex).

[Term]
id: CL:4042017
name: alpha1-tanycyte
def: "The dorsal-most tanycyte type of the third venticle.  These cells projects into the ventromedial or dorsomedial nucleus of the hypothalamus. This type of tanycyte extends its protrusions close to parenchymal neurons without contacting blood vessels. It expresses the glial marker S-100β." [PMID:16344112, PMID:26578855, wikipedia:Tanycyte]
comment: In rodents, a1 tanycytes are known to express DARPP-32, GPR50, NA Vimentin, Connexin 43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018). {xref="PMID:26578855"}
subset: human_subset
subset: mouse_subset
synonym: "DMH tanycyte" RELATED [PMID:29351662]
synonym: "VMH tanycyte" RELATED [PMID:29351662]
is_a: CL:0002085 ! tanycyte
relationship: BFO:0000050 UBERON:0004642 ! part of third ventricle ependyma
relationship: RO:0002292 PR:000014419 ! expresses protein S100-B

[Term]
id: CL:4042018
name: alpha2-tanycyte
def: "Tanycyte of the third ventricle, located immediately ventral to alpha-1 tanycytes. These cells project to the ventromedial and arcuate nuclei of the hypothalamus and express the glial marker S-100β." [PMID:16344112, PMID:26578855, PMID:29351662, wikipedia:Tanycyte]
comment: In rodents, this type of tanycyte is more developmentally advanced than alpha1 tanycytes, shows a high neurogenic competence and expresses the following markers DARPP-32, Vimentin, GPR50, Connexin-43, GLT-1, GLUT1(+) (Goodman and Hajihosseini 2015; Prevot et al., 2018) {xref="PMID:26578855"}
subset: human_subset
subset: mouse_subset
synonym: "dmARH tanycyte" RELATED [PMID:29351662]
is_a: CL:0002085 ! tanycyte
relationship: RO:0002131 UBERON:0001932 ! overlaps arcuate nucleus of hypothalamus
relationship: RO:0002292 PR:000014419 ! expresses protein S100-B

[Term]
id: CL:4042019
name: beta1-tanycyte
def: "A type of tanycyte located in ventral part of the lateral wall of the third ventricle and in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending into the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." [PMID:16344112, PMID:26578855, PMID:29351662, Wikipedia:Tanycyte]
subset: human_subset
subset: mouse_subset
synonym: "vmARH tanycyte" RELATED [PMID:29351662]
is_a: CL:0002085 ! tanycyte
is_a: CL:1100001 ! secretory epithelial cell
relationship: BFO:0000050 UBERON:0006250 ! part of infundibular recess of 3rd ventricle
relationship: RO:0002131 UBERON:0002197 ! overlaps median eminence of neurohypophysis
relationship: RO:0002215 GO:0032274 ! capable of gonadotropin secretion
relationship: RO:0002292 PR:000007479 ! expresses fibroblast growth factor 1
relationship: RO:0002292 PR:000007489 ! expresses fibroblast growth factor 2

[Term]
id: CL:4042020
name: beta2-tanycyte
def: "A type of tanycyte located in the floor of third ventricle and the infindibular recess. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH)." [PMID:16344112, PMID:26578855, PMID:29351662, wikipedia:Tanycyte]
subset: human_subset
subset: mouse_subset
synonym: "ME tanycyte" RELATED [PMID:29351662]
is_a: CL:0002085 ! tanycyte
relationship: BFO:0000050 UBERON:0006250 ! part of infundibular recess of 3rd ventricle
relationship: RO:0002131 UBERON:0002197 ! overlaps median eminence of neurohypophysis
relationship: RO:0002292 PR:000007479 ! expresses fibroblast growth factor 1
relationship: RO:0002292 PR:000007489 ! expresses fibroblast growth factor 2

[Term]
id: CL:4042023
name: striatal pthlh-expressing interneuron
def: "A GABAergic interneuron expressing PTHLH and PVALB that has its soma in a striatum. This GABAergic interneuron type presents a spatial expression gradient of PVALB in the mouse striatum." [PMID:30134177, PMID:37292997]
comment: According to spatial transcriptomic data in the human striatum, pthlh-expressing interneurons are one of the most abundant population of interneurons in the striatum (Leonardo D. Garma, et al., 2024). {xref="PMID:37292997"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
synonym: "PTHLH/PVALB cell" RELATED [PMID:37292997]
synonym: "PTHLH +/PVALB+ interneuron" RELATED [PMID:37292997]
is_a: CL:0002613 ! striatum neuron
is_a: CL:0011005 ! GABAergic interneuron
relationship: RO:0002292 PR:000013433 ! expresses parathyroid hormone-related protein
relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha

[Term]
id: CL:4042035
name: molecular layer interneuron
def: "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties." [PMID:30742002, PMID:33075461, PMID:34616064, PMID:38692278]
subset: human_subset
subset: mouse_subset
synonym: "MLI" RELATED [PMID:33075461] {RELATED="OMO:0003000"}
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
relationship: RO:0002100 UBERON:0002974 ! has soma location molecular layer of cerebellar cortex

[Term]
id: CL:4042039
name: caudal ganglionic eminence derived neuron
def: "A neuron of the central nervous system that develops from a caudal ganglionic eminence." [https://www.ncbi.nlm.nih.gov/books/NBK98190/, PMID:12593982, PMID:12637172, PMID:20130169]
comment: Neurons derived from the caudal ganglionic eminence consist mostly of neurons populating the cortical layers of the brain and some subcortical areas such as the globus pallidus, the striatus and the hippocampus. Amongst neurons derived from the caudal ganglionic eminence there are cortical GABAergic neurons such as Pax6, Lamp5, VIP, sncg, GABAergic; in the hippocampus, mossy fibers, pyramidal neurons, granule neurons and interneurons; in the striatum and globus pallidus, medium spiny projection neurons. {xref="https://www.ncbi.nlm.nih.gov/books/NBK98190/", xref="PMID:12637172", xref="PMID:12593982", xref="PMID:20130169"}
subset: human_subset
subset: mouse_subset
is_a: CL:2000029 ! central nervous system neuron
relationship: RO:0002202 UBERON:0004026 ! develops from caudal ganglionic eminence

[Term]
id: CL:4042040
name: glutamatergic neuron of the basal ganglia
def: "A glutametergic neuron with its soma located in a basal ganglia. This neuron type is involved in motor control, decision making and learning." [DOI:10.1016/j.jocn.2021.05.056, PMID:11307040, PMID:16276355]
comment: The glutametergic neurons in the basal ganglia are part of a series of different circuits such as the corticolstriatal circuit, which is involved in regulating voluntary movements. The subthalamic nucleus circuit, which is involved in modulating the output of the basal ganglia, particularly in controlling movement initiation and inhibition. The thalamocortical loop, which is involved in refining motor movements and integrating sensory information with motor commanding. {xref="PMID:30498197", xref="PMID:22498715", xref="PMID:33785138"}
subset: human_reference_atlas
subset: human_subset
subset: mouse_subset
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:2000029 ! central nervous system neuron
relationship: RO:0002100 UBERON:0002420 ! has soma location basal ganglion

[Term]
id: CL:4052002
name: syncytial cell
def: "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." [PMID:20851884, Wikipedia:Syncytium]
subset: human_subset
subset: mouse_subset
synonym: "syncytium" EXACT [WBbt:0008074]
is_a: CL:0000228 ! multinucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
intersection_of: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion
relationship: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion

[Term]
id: CL:4052015
name: endocrine gland capillary endothelial cell
def: "Any capillary endothelial cell that is part of an endocrine gland." [PMID:18480313]
subset: human_subset
subset: mouse_subset
is_a: CL:0002144 ! capillary endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: BFO:0000050 UBERON:0002368 ! part of endocrine gland
relationship: BFO:0000050 UBERON:0002368 ! part of endocrine gland

[Term]
id: CL:4052016
name: pituitary gland capillary endothelial cell
def: "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling." [PMID:10810312, PMID:32910242]
comment: In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure. {xref="PMID:4899902"}
subset: human_subset
subset: mouse_subset
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:2000004 ! pituitary gland cell
is_a: CL:2000044 ! brain microvascular endothelial cell
is_a: CL:4052015 ! endocrine gland capillary endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: BFO:0000050 UBERON:0000007 ! part of pituitary gland

[Term]
id: CL:4052017
name: choroid plexus capillary endothelial cell
def: "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF)." [https://www.ncbi.nlm.nih.gov/books/NBK27998/, PMID:18480313, PMID:32375819]
subset: human_subset
subset: mouse_subset
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000044 ! brain microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus
relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus

[Term]
id: CL:4052030
name: adventitial fibroblast
def: "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression" [PMID:28705796, PMID:36718802]
comment: Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice. {xref="PMID:36718802"}
subset: cellxgene_subset
subset: human_subset
subset: mouse_subset
is_a: CL:0000057 ! fibroblast
is_a: CL:0000151 ! secretory cell
is_a: CL:0002503 ! adventitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood vessel
relationship: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood vessel
relationship: RO:0002215 GO:0001816 ! capable of cytokine production
relationship: RO:0002215 GO:0070278 ! capable of extracellular matrix constituent secretion

[Term]
id: CL:4052045
name: steroidogenic stromal cell of ovary
def: "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones." [doi:/10.1101/2024.12.15.628550, PMID:36205477]
subset: human_subset
subset: mouse_subset
synonym: "Enpp2− interstitial cell" RELATED [PMID:36205477]
synonym: "steroidogenic interstitial stromal cell" BROAD [PMID:36205477]
synonym: "steroidogenic stromal cell" BROAD [PMID:36205477]
is_a: CL:0002132 ! stromal cell of ovary
intersection_of: CL:0000499 ! stromal cell
intersection_of: BFO:0000050 UBERON:0006960 ! part of ovary stroma
intersection_of: RO:0002215 GO:0120178 ! capable of steroid hormone biosynthetic process
relationship: BFO:0000050 UBERON:0006960 ! part of ovary stroma
relationship: RO:0002215 GO:0120178 ! capable of steroid hormone biosynthetic process

[Term]
id: CL:4072001
name: newly formed oligodendrocyte
def: "A post-mitotic oligodendrocyte that has exited the cell cycle and begun early stage differentiation. The cell begins to acquire oligodendrocyte-like characteristics but has not yet initiated myelination. In mice, NFOL is marked by the expression of Tcf7l2 and Cemip2 (also known as Tmem2), among other early myelin-related genes. These markers highlight cells transitioning from a precursor to a more differentiated, pre-myelinating state." [PMID:27284195, PMID:39233334]
subset: human_subset
subset: mouse_subset
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0000128 ! oligodendrocyte
relationship: RO:0002207 CL:4023059 ! directly develops from committed oligodendrocyte precursor

[Term]
id: CL:4072002
name: myelin-forming oligodendrocyte
def: "A postmitotic and differentiated oligodendrocyte derived from a oligodendrocyte progenitor cell. A myelin-forming oligodendrocyte begins the expression of myelin genes and actively engages in the myelination process. In mice and humans, it is characterized by the upregulation of the key myelin-associated markers Mbp and Opalin. Additionally, Ctps (CTP synthase) shows peak expression at this stage, suggesting a heightened demand for nucleotide biosynthesis during membrane expansion and myelin production." [PMID:27284195, PMID:30837646, PMID:39233334, PMID:9473608]
subset: human_subset
subset: mouse_subset
is_a: CL:0000128 ! oligodendrocyte
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: RO:0002207 CL:4072001 ! directly develops from newly formed oligodendrocyte
relationship: RO:0002215 GO:0032289 ! capable of central nervous system myelin formation

[Term]
id: CL:4072003
name: mature myelinating oligodendrocyte
def: "A post-mitotic oligodendrocyte derived from a myelin-forming oligodendrocyte (MFOL). A mature Myelinating Oligodendrocyte is a fully differentiated cell that is actively engaged in myelination. In addition to high expression of canonical myelin genes (e.g., Mbp, Plp1, Mog), a MOL can be distinguished by the expression of stage-enriched genes Grm3, Klk6, Ptgds, Anxa5, and Hopx in mice. These markers reflect the functional specialization of a mature oligodendrocyte, including roles in signalling, lipid metabolism, and myelin maintenance." [PMID:27284195, PMID:33203872]
subset: human_subset
subset: mouse_subset
is_a: CL:0000128 ! oligodendrocyte
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: RO:0002207 CL:4072002 ! directly develops from myelin-forming oligodendrocyte
relationship: RO:0002215 GO:0032289 ! capable of central nervous system myelin formation

[Term]
id: CL:4072102
name: Purkinje layer interneuron
def: "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex." [PMID:35803588]
subset: human_subset
subset: mouse_subset
is_a: CL:4023057 ! cerebellar inhibitory GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex
relationship: RO:0002100 UBERON:0002979 ! has soma location Purkinje cell layer of cerebellar cortex

[Term]
id: CL:4300028
name: cerebellar GABAergic neuron (Mmus)
def: "A cerebellar neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:28 CB GABA." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "28 CB GABA" EXACT []
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:1001611 ! cerebellar neuron
relationship: RO:0002100 MBA:512 ! has soma location Cerebellum
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4300029
name: cerebellar glutamatergic neuron (Mmus)
def: "A cerebellum glutamatergic neuron of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:29 CB Glut." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "29 CB Glut" EXACT []
is_a: CL:2000028 ! cerebellum glutamatergic neuron
relationship: RO:0002100 MBA:512 ! has soma location Cerebellum
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4300031
name: OPC-Oligo cell (Mmus)
def: "A cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Class:31 OPC-Oligo." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "31 OPC-Oligo" EXACT []
is_a: CL:0000255 ! eukaryotic cell
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4300101
name: STR D1 Gaba direct pathway medium spiny neuron (Mmus)
def: "A direct pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prkch (Mmus), Slc32a1 (Mmus), Drd1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:061 STR D1 Gaba." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "061 STR D1 Gaba" EXACT []
is_a: CL:4023026 ! direct pathway medium spiny neuron

[Term]
id: CL:4300102
name: STR D2 Gaba indirect pathway medium spiny neuron (Mmus)
def: "A indirect pathway medium spiny neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Adora2a (Mmus), Phactr1 (Mmus), Pcp4l1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:062 STR D2 Gaba." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "062 STR D2 Gaba" EXACT []
is_a: CL:4023029 ! indirect pathway medium spiny neuron

[Term]
id: CL:4300348
name: DCO Il22 Gly-Gaba cerebellar neuron (Mmus)
def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem204 (Mmus), Slc6a5 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:308 DCO Il22 Gly-Gaba." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "308 DCO Il22 Gly-Gaba" EXACT []
is_a: CL:0008059 ! GABA-Gly neuron
is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus)

[Term]
id: CL:4300349
name: Purkinje layer interneuron (Mmus)
def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Rgs6 (Mmus), Slc6a5 (Mmus), Shisa9 (Mmus), Zic1 (Mmus), Bmp6 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:309 CB PLI Gly-Gaba." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "309 CB PLI Gly-Gaba" EXACT []
is_a: CL:4072102 ! Purkinje layer interneuron
is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus)

[Term]
id: CL:4300351
name: CBX MLI Megf11 Gaba molecular layer interneuron (Mmus)
def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Homer3 (Mmus), Tfap2b (Mmus), Sorcs3 (Mmus), Cacna1e (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:311 CBX MLI Megf11 Gaba." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "311 CBX MLI Megf11 Gaba" EXACT []
is_a: CL:4042035 ! molecular layer interneuron
is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus)

[Term]
id: CL:4300353
name: Purkinje cell (Mmus)
def: "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:313 CBX Purkinje Gaba." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "313 CBX Purkinje Gaba" EXACT []
is_a: CL:0000121 ! Purkinje cell
is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus)

[Term]
id: CL:4300354
name: cerebellar granule cell (Mmus)
def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Ror1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:314 CB Granule Glut." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "314 CB Granule Glut" EXACT []
is_a: CL:0001031 ! cerebellar granule cell
is_a: CL:4300029 ! cerebellar glutamatergic neuron (Mmus)

[Term]
id: CL:4300358
name: subcortical astrocyte (Mmus)
def: "A transcriptomically defined type of astrocyte located predominantly in the ventral and posterior subcortical areas.   It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Cd38 (Mmus), Agt (Mmus), Itih3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:318 Astro-NT NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "318 Astro-NT NN" EXACT []
synonym: "non-telencephalic astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:4300359
name: astrocyte of cerebrum (Mmus)
def: "A transcritpomically defined type of astrocytes primarily restricted to the dorsal regions of the cerebrum. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Lhx2 (Mmus), Gpc5 (Mmus), Nr2f1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:319 Astro-TE NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "319 Astro-TE NN" EXACT []
synonym: "telencephalic astrocyte" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:4300360
name: olfactory areas astrocyte (Mmus)
def: "A transcriptomically defined type of astrocyte located exclusively in the olfactory areas. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:320 Astro-OLF NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "320 Astro-OLF NN" EXACT []
is_a: CL:0000127 ! astrocyte

[Term]
id: CL:4300362
name: tanycyte (Mmus)
def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Apoe (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:322 Tanycyte NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "322 Tanycyte NN" EXACT []
is_a: CL:0002085 ! tanycyte

[Term]
id: CL:4300363
name: ependymal cell (Mmus)
def: "A ependymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Tmem212 (Mmus), Rarres2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:323 Ependymal NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "323 Ependymal NN" EXACT []
is_a: CL:0000065 ! ependymal cell

[Term]
id: CL:4300366
name: oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:326 OPC NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "326 OPC NN" EXACT []
is_a: CL:0002453 ! oligodendrocyte precursor cell
is_a: CL:4300031 ! OPC-Oligo cell (Mmus)

[Term]
id: CL:4300367
name: oligodendrocyte (Mmus)
def: "A oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Gjc3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:327 Oligo NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "327 Oligo NN" EXACT []
is_a: CL:0000128 ! oligodendrocyte
is_a: CL:4300031 ! OPC-Oligo cell (Mmus)

[Term]
id: CL:4300370
name: VLMC NN vascular leptomeningeal cell (Mmus)
def: "A vascular leptomeningeal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Slc6a13 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Subclass:330 VLMC NN." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "330 VLMC NN" EXACT []
is_a: CL:4023051 ! vascular leptomeningeal cell
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4301571
name: DCO Il22 Gly-Gaba_1 cerebellar neuron (Mmus)
def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Rftn1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1141 DCO Il22 Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1141 DCO Il22 Gly-Gaba_1" EXACT []
is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus)

[Term]
id: CL:4301573
name: DCO Il22 Gly-Gaba_3 cerebellar neuron (Mmus)
def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fat2 (Mmus), Slc6a5 (Mmus), Cgnl1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1143 DCO Il22 Gly-Gaba_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1143 DCO Il22 Gly-Gaba_3" EXACT []
is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus)

[Term]
id: CL:4301574
name: CB PLI Gly-Gaba_1 Purkinje layer interneuron (Mmus)
def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hmga2 (Mmus), Afap1l2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1144 CB PLI Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1144 CB PLI Gly-Gaba_1" EXACT []
is_a: CL:4300349 ! Purkinje layer interneuron (Mmus)

[Term]
id: CL:4301575
name: Lugaro cell (Mmus)
def: "A Lugaro cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pthlh (Mmus), Tfap2b (Mmus), Rspo2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1145 CB PLI Gly-Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Rationale for assigning this type to reference data: Mapping of this cell type is supported by analysis: https://github.com/Cellular-Semantics/cellular_semantics_notebooks Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1145 CB PLI Gly-Gaba_2" EXACT []
is_a: CL:0011006 ! Lugaro cell
is_a: CL:4300349 ! Purkinje layer interneuron (Mmus)

[Term]
id: CL:4301576
name: CB PLI Gly-Gaba_3 Purkinje layer interneuron (Mmus)
def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pax2 (Mmus), C1ql3 (Mmus), Tfap2b (Mmus), Gabrb1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1146 CB PLI Gly-Gaba_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1146 CB PLI Gly-Gaba_3" EXACT []
is_a: CL:4300349 ! Purkinje layer interneuron (Mmus)

[Term]
id: CL:4301578
name: cerebellar Golgi cell (Mmus)
def: "A cerebellar Golgi cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Zfp385c (Mmus), Tfap2b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1148 CBX Golgi Gly-Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1148 CBX Golgi Gly-Gaba_1" EXACT []
synonym: "310 CBX Golgi Gly-Gaba" EXACT []
is_a: CL:0000119 ! cerebellar Golgi cell
is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus)

[Term]
id: CL:4301579
name: CBX MLI Megf11 Gaba_1 molecular layer interneuron (Mmus)
def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dnah11 (Mmus), Sla (Mmus), Gldc (Mmus), Sdk2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1149 CBX MLI Megf11 Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1149 CBX MLI Megf11 Gaba_1" EXACT []
is_a: CL:4300351 ! CBX MLI Megf11 Gaba molecular layer interneuron (Mmus)

[Term]
id: CL:4301580
name: CBX MLI Megf11 Gaba_2 molecular layer interneuron (Mmus)
def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Pvalb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1150 CBX MLI Megf11 Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1150 CBX MLI Megf11 Gaba_2" EXACT []
is_a: CL:4300351 ! CBX MLI Megf11 Gaba molecular layer interneuron (Mmus)

[Term]
id: CL:4301582
name: CBX Purkinje Gaba_1 Purkinje cell (Mmus)
def: "A Purkinje cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pcp2 (Mmus), Stk17b (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1152 CBX Purkinje Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1152 CBX Purkinje Gaba_1" EXACT []
is_a: CL:4300353 ! Purkinje cell (Mmus)

[Term]
id: CL:4301583
name: CBX Purkinje Gaba_2 Purkinje cell (Mmus)
def: "A Purkinje cell of the Mus musculus brain. Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1153 CBX Purkinje Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1153 CBX Purkinje Gaba_2" EXACT []
is_a: CL:4300353 ! Purkinje cell (Mmus)

[Term]
id: CL:4301584
name: CB Granule Glut_1 cerebellar granule cell (Mmus)
def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1154 CB Granule Glut_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1154 CB Granule Glut_1" EXACT []
is_a: CL:4300354 ! cerebellar granule cell (Mmus)

[Term]
id: CL:4301585
name: CB Granule Glut_2 cerebellar granule cell (Mmus)
def: "A cerebellar granule cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gabra6 (Mmus), Gap43 (Mmus), Rab37 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1155 CB Granule Glut_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1155 CB Granule Glut_2" EXACT []
is_a: CL:4300354 ! cerebellar granule cell (Mmus)

[Term]
id: CL:4301586
name: unipolar brush cell (Mmus)
def: "A unipolar brush cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sln (Mmus), Lmx1a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1156 DCO UBC Glut_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1156 DCO UBC Glut_1" EXACT []
synonym: "315 DCO UBC Glut" EXACT []
is_a: CL:4023161 ! unipolar brush cell
is_a: CL:4300029 ! cerebellar glutamatergic neuron (Mmus)

[Term]
id: CL:4301589
name: Astro-NT NN_1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Lhfpl3 (Mmus), Gria1 (Mmus), Hopx (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1159 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1159 Astro-NT NN_1" EXACT []
is_a: CL:4300358 ! subcortical astrocyte (Mmus)

[Term]
id: CL:4301590
name: Astro-NT NN_2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Itih3 (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1160 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1160 Astro-NT NN_2" EXACT []
is_a: CL:4300358 ! subcortical astrocyte (Mmus)

[Term]
id: CL:4301591
name: Astro-TE NN_1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Camk2a (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1161 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1161 Astro-TE NN_1" EXACT []
is_a: CL:4300359 ! astrocyte of cerebrum (Mmus)

[Term]
id: CL:4301592
name: Astro-TE NN_2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Hepacam (Mmus), E330013P04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1162 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1162 Astro-TE NN_2" EXACT []
is_a: CL:4300359 ! astrocyte of cerebrum (Mmus)

[Term]
id: CL:4301593
name: Astro-TE NN_3 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Grin2c (Mmus), Dcc (Mmus), Slc7a10 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1163 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1163 Astro-TE NN_3" EXACT []
is_a: CL:4300359 ! astrocyte of cerebrum (Mmus)

[Term]
id: CL:4301595
name: Astro-TE NN_5 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Thbs4 (Mmus), Kcnk10 (Mmus), Pak1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1165 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1165 Astro-TE NN_5" EXACT []
is_a: CL:4300359 ! astrocyte of cerebrum (Mmus)

[Term]
id: CL:4301596
name: Astro-OLF NN_1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Igfbp2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1166 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1166 Astro-OLF NN_1" EXACT []
is_a: CL:4300360 ! olfactory areas astrocyte (Mmus)

[Term]
id: CL:4301597
name: Astro-OLF NN_2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Hs3st3a1 (Mmus), Slco1c1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1167 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1167 Astro-OLF NN_2" EXACT []
is_a: CL:4300360 ! olfactory areas astrocyte (Mmus)

[Term]
id: CL:4301598
name: Astro-OLF NN_3 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ednrb (Mmus), Hs3st3a1 (Mmus), C230072F16Rik (Mmus), Gria2 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1168 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1168 Astro-OLF NN_3" EXACT []
is_a: CL:4300360 ! olfactory areas astrocyte (Mmus)

[Term]
id: CL:4301602
name: Tanycyte NN_1 tanycyte (Mmus)
def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Lpl (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1172 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1172 Tanycyte NN_1" EXACT []
is_a: CL:4300362 ! tanycyte (Mmus)

[Term]
id: CL:4301603
name: Tanycyte NN_2 tanycyte (Mmus)
def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Ccdc170 (Mmus), Nkx2-4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1173 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1173 Tanycyte NN_2" EXACT []
is_a: CL:4300362 ! tanycyte (Mmus)

[Term]
id: CL:4301608
name: choroid plexus epithelial cell (Mmus)
def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1178 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1178 CHOR NN_1" EXACT []
synonym: "325 CHOR NN" EXACT []
is_a: CL:0000706 ! choroid plexus epithelial cell

[Term]
id: CL:4301611
name: commited oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1181 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463]
comment: Rationale for assigning this type to reference data: Mapping of this cell set to a differentiation-committed oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Gpr17, Bmp4, Neu4, Fyn in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"}
subset: mouse_subset
synonym: "1181 COP NN_1" EXACT []
is_a: CL:4023059 ! committed oligodendrocyte precursor
is_a: CL:4300367 ! oligodendrocyte (Mmus)

[Term]
id: CL:4301612
name: newly formed oligodendrocyte (Mmus)
def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ptprb (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1182 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463]
comment: Rationale for assigning this type to reference data: Mapping of this cell set to a newly formed oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Tcf7l2, Klk6, Cemip2, Casr in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"}
subset: mouse_subset
synonym: "1182 NFOL NN_2" EXACT []
is_a: CL:4072001 ! newly formed oligodendrocyte
is_a: CL:4300367 ! oligodendrocyte (Mmus)

[Term]
id: CL:4301613
name: myelin-forming oligodendrocyte (Mmus)
def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Sec14l5 (Mmus), 9630013A20Rik (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1183 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463]
comment: Rationale for assigning this type to reference data: Mapping of this cell set to a myelin-forming oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Ctps, Cldn11 in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"}
subset: mouse_subset
synonym: "1183 MFOL NN_3" EXACT []
is_a: CL:4072002 ! myelin-forming oligodendrocyte
is_a: CL:4300367 ! oligodendrocyte (Mmus)

[Term]
id: CL:4301614
name: mature myelinating oligodendrocyte (Mmus)
def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), Anln (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1184 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1126/science.aaf6463]
comment: Rationale for assigning this type to reference data: Mapping of this cell set to a mature myelinating oligodendrocyte is supported by spatial transcriptomic evidence and specific expression of Klk6 in the context of oligodendrocyte lineage cells. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1126/science.aaf6463"}
subset: mouse_subset
synonym: "1184 MOL NN_4" EXACT []
is_a: CL:4072003 ! mature myelinating oligodendrocyte
is_a: CL:4300367 ! oligodendrocyte (Mmus)

[Term]
id: CL:4301615
name: olfactory ensheathing cell (Mmus)
def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Npy (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1185 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1185 OEC NN_1" EXACT []
synonym: "32 OEC" EXACT []
synonym: "328 OEC NN" EXACT []
is_a: CL:0011028 ! olfactory ensheathing cell
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4301616
name: arachnoid barrier cell (Mmus)
def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Thbd (Mmus), Ccn3 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1186 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1186 ABC NN_1" EXACT []
synonym: "329 ABC NN" EXACT []
is_a: CL:4023097 ! arachnoid barrier cell
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4301625
name: border associated macrophage (Mmus)
def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Maf (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Supertype:1195 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1195 BAM NN_1" EXACT []
synonym: "335 BAM NN" EXACT []
is_a: CL:4042003 ! border associated macrophage
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4304384
name: hypothalamic gonadotropin-releasing hormone neuron (Mmus)
def: "A hypothalamic gonadotropin-releasing hormone neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gnrh1 (Mmus). It is glutamatergic (inferred from expression of Gad1, Slc17a6, Gad2). These cells are located in the Hypothalamus, Olfactory areas, Pallidum, brain , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part, Medial septal nucleus, Diagonal band nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:2564 HY Gnrh1 Glut_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "0628 HY Gnrh1 Glut_1" EXACT []
synonym: "142 HY Gnrh1 Glut" EXACT []
synonym: "15 HY Gnrh1 Glut" EXACT []
synonym: "2564 HY Gnrh1 Glut_1" EXACT []
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0011111 ! hypothalamic gonadotropin-releasing hormone neuron
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4306426
name: pinealocyte (Mmus)
def: "A pinealocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cngb3 (Mmus), Ush2a (Mmus). It is glutamatergic (inferred from expression of Ddc, Slc17a6, Slc17a7). These cells are located in the brain , in or close to the regions: third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:4606 Pineal Crx Glut_1." [https://doi.org/10.1038/s41586-023-06812-z, https://doi.org/10.1111/j.1600-079x.1996.tb00284.x, https://doi.org/10.3389/fendo.2019.00590]
comment: Rationale for assigning this type to reference data: Consistent with this cell set being composed of Pinealocytes, a combination of Pinealocyte markers Gngt1 and Crx can identify the cells in this cluster with a confidence (F-beta score) of 0.91 in the context of glutamatergic cells (Pinealocytes release glutamate) from the hippocampal formation dissection (which includes the pineal gland). Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1111/j.1600-079x.1996.tb00284.x", xref="https://doi.org/10.3389/fendo.2019.00590"}
subset: mouse_subset
synonym: "1030 Pineal Crx Glut_1" EXACT []
synonym: "25 Pineal Glut" EXACT []
synonym: "262 Pineal Crx Glut" EXACT []
synonym: "4606 Pineal Crx Glut_1" EXACT []
is_a: CL:0000652 ! pinealocyte
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus
relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Ddc, Slc17a6, Slc17a7"} ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:4306992
name: DCO Il22 Gly-Gaba_2 cerebellar neuron (Mmus)
def: "A cerebellar neuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Il22 (Mmus), Edaradd (Mmus). It is distinguished from other DCO Il22 Gly-Gaba cells by expression of Ppp1r17. It is GABAergic and glycinergic (inferred from expression of Slc32a1, Hdc, Slc6a5, Gad2, Gad1). These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Paraflocculus, arbor vitae, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5172 DCO Il22 Gly-Gaba_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1142 DCO Il22 Gly-Gaba_2" EXACT []
synonym: "5172 DCO Il22 Gly-Gaba_2" EXACT []
is_a: CL:4300348 ! DCO Il22 Gly-Gaba cerebellar neuron (Mmus)

[Term]
id: CL:4307005
name: CB PLI GABA Ly6d Purkinje layer interneuron
def: "A Purkinje layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ly6d (Mmus), Kit (Mmus). It is distinguished from other CB PLI Gly-Gaba cells by expression of Ly6d. It is GABAergic (inferred from expression of Gad1, Gad2, Slc32a1). These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae, Interposed nucleus, Nodulus (X) . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5185 CB PLI Gly-Gaba_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. Warning: Despite its name, CB PLI Gly-Gaba_4 does not secrete the neurotransmitter Gly, as assessed by expression of multiple marker genes.
subset: mouse_subset
synonym: "1147 CB PLI Gly-Gaba_4" EXACT []
synonym: "5185 CB PLI Gly-Gaba_4" EXACT []
is_a: CL:4300349 ! Purkinje layer interneuron (Mmus)

[Term]
id: CL:4307012
name: CBX MLI Cdh22 Gaba molecular layer interneuron (Mmus)
def: "A molecular layer interneuron of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cdh1 (Mmus), Acvr1c (Mmus), Adamts15 (Mmus), Pax2 (Mmus). It is distinguished from other CB GABA cells by expression of Cdh1, Acvr1c, Adamts15, Pax2. It is GABAergic (inferred from expression of Gad1, Gad2, Slc32a1). These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5192 CBX MLI Cdh22 Gaba_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1151 CBX MLI Cdh22 Gaba_1" EXACT []
synonym: "312 CBX MLI Cdh22 Gaba" EXACT []
synonym: "5192 CBX MLI Cdh22 Gaba_1" EXACT []
is_a: CL:4042035 ! molecular layer interneuron
is_a: CL:4300028 ! cerebellar GABAergic neuron (Mmus)

[Term]
id: CL:4307026
name: Bergmann glial cell (Mmus)
def: "A Bergmann glial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr37l1 (Mmus), Ctxn3 (Mmus). It is distinguished from other Astro-Epen cells by expression of Gpr37l1, Ctxn3. These cells are located in the Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5206 Bergmann NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1157 Bergmann NN_1" EXACT []
synonym: "316 Bergmann NN" EXACT []
synonym: "5206 Bergmann NN_1" EXACT []
is_a: CL:0000644 ! Bergmann glial cell

[Term]
id: CL:4307027
name: cerebellar astrocyte (Mmus)
def: "A transcriptomically defined type of astrocyte localized exclusively in the cerebellum beneath the Purkinje cell layer. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Efemp1 (Mmus). Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5207 Astro-CB NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1158 Astro-CB NN_1" EXACT []
synonym: "317 Astro-CB NN" EXACT []
synonym: "5207 Astro-CB NN_1" EXACT []
is_a: CL:0002603 ! astrocyte of the cerebellum

[Term]
id: CL:4307028
name: Astro-NT NN_1 Galnt15 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Galnt15 (Mmus), Agt (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Galnt15. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5208 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5208 Astro-NT NN_1" EXACT []
is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus)

[Term]
id: CL:4307029
name: Astro-NT NN_1 Slc36a2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Slc36a2 (Mmus), Sfrp5 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Slc36a2, Sfrp5. These cells are located in the Midbrain, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5209 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5209 Astro-NT NN_1" EXACT []
is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus)

[Term]
id: CL:4307030
name: Astro-NT NN_1 Nuf2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Sfrp5 (Mmus), Cldn10 (Mmus), Riiad1 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Nuf2, Shroom3. These cells are located in the Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5210 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5210 Astro-NT NN_1" EXACT []
is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus)

[Term]
id: CL:4307031
name: Astro-NT NN_1 Six3os1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Six3os1 (Mmus), Slc36a2 (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Six3os1. These cells are located in the Striatum-like amygdalar nuclei, Olfactory areas, brain , in or close to the regions: Medial amygdalar nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5211 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5211 Astro-NT NN_1" EXACT []
is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus)

[Term]
id: CL:4307032
name: Astro-NT NN_1 Kcnk10 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Agt (Mmus), Prss35 (Mmus), C4b (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Kcnk10, C4b. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5212 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5212 Astro-NT NN_1" EXACT []
is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus)

[Term]
id: CL:4307033
name: Astro-NT NN_1 Mecom astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dao (Mmus), Mecom (Mmus), Fbln5 (Mmus), Prelp (Mmus). It is distinguished from other Astro-NT NN_1 cells by expression of Mecom, Prelp. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, Paraflocculus, Flocculus, Dorsal cochlear nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5213 Astro-NT NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5213 Astro-NT NN_1" EXACT []
is_a: CL:4301589 ! Astro-NT NN_1 astrocyte (Mmus)

[Term]
id: CL:4307034
name: Astro-NT NN_2 Fzd2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Sfrp5 (Mmus), Gria2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fzd2, Gria2, Ttll3. These cells are located in the Midbrain, Thalamus, Pons , in or close to the regions: Midbrain reticular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5214 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5214 Astro-NT NN_2" EXACT []
is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus)

[Term]
id: CL:4307035
name: Astro-NT NN_2 Sez6l astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), A330076C08Rik (Mmus), Otx2 (Mmus), Unc13c (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Sez6l, Unc13c. These cells are located in the Thalamus , in or close to the regions: Posterior complex of the thalamus, Ventral posteromedial nucleus of the thalamus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5215 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5215 Astro-NT NN_2" EXACT []
is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus)

[Term]
id: CL:4307036
name: Astro-NT NN_2 Fam227b astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc7a10 (Mmus), Cyp26b1 (Mmus), Igfbp2 (Mmus), Shroom3 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Fam227b, Shroom3. These cells are located in the Midbrain, Medulla, Pons . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5216 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5216 Astro-NT NN_2" EXACT []
is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus)

[Term]
id: CL:4307037
name: Astro-NT NN_2 Gm30524 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), A330076C08Rik (Mmus), Fbln5 (Mmus), Mdga2 (Mmus). It is distinguished from other Astro-NT NN_2 cells by expression of Gm30524. These cells are located in the Medulla, Cerebellum, brain , in or close to the regions: Ventral cochlear nucleus, arbor vitae . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5217 Astro-NT NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5217 Astro-NT NN_2" EXACT []
is_a: CL:4301590 ! Astro-NT NN_2 astrocyte (Mmus)

[Term]
id: CL:4307038
name: Astro-TE NN_1 Myoc astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Lhx2 (Mmus), Kcne1l (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Kcne1l, Alpk1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5218 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5218 Astro-TE NN_1" EXACT []
is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus)

[Term]
id: CL:4307039
name: Astro-TE NN_1 Rasl10b astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gfap (Mmus), Ddn (Mmus), Myoc (Mmus), Rasl10b (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Rasl10b, Igfbp5. These cells are located in the Hippocampal region, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5219 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5219 Astro-TE NN_1" EXACT []
is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus)

[Term]
id: CL:4307040
name: Astro-TE NN_1 Lncpint astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Dio2 (Mmus), Lncpint (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Lncpint. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5220 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5220 Astro-TE NN_1" EXACT []
is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus)

[Term]
id: CL:4307041
name: Astro-TE NN_1 Jph4 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Myoc (Mmus), Sptbn2 (Mmus), Alpk1 (Mmus). It is distinguished from other Astro-TE NN_1 cells by expression of Myoc, Jph4, Alpk1. It is glutamatergic (inferred from expression of Aldh1a1, Slc17a7). These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5221 Astro-TE NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5221 Astro-TE NN_1" EXACT []
is_a: CL:0000151 ! secretory cell
is_a: CL:4301591 ! Astro-TE NN_1 astrocyte (Mmus)
relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Aldh1a1, Slc17a7"} ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:4307042
name: Astro-TE NN_2 Clstn2 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gm6145 (Mmus), E330013P04Rik (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Clstn2. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Field CA3, stratum oriens, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5222 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5222 Astro-TE NN_2" EXACT []
is_a: CL:4301592 ! Astro-TE NN_2 astrocyte (Mmus)

[Term]
id: CL:4307043
name: Astro-TE NN_2 Mcm6 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mcm6 (Mmus), Egfr (Mmus), Pcsk6 (Mmus). It is distinguished from other Astro-TE NN_2 cells by expression of Mcm6. These cells are located in the Hippocampal region , in or close to the regions: Dentate gyrus, molecular layer, Dentate gyrus, polymorph layer, Dentate gyrus, granule cell layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5223 Astro-TE NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5223 Astro-TE NN_2" EXACT []
is_a: CL:4301592 ! Astro-TE NN_2 astrocyte (Mmus)

[Term]
id: CL:4307044
name: Astro-TE NN_3 Cxcl5 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Cxcl5 (Mmus), Ddn (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Cxcl5, Kif5a. These cells are located in the Hippocampal region, Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5224 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5224 Astro-TE NN_3" EXACT []
is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus)

[Term]
id: CL:4307045
name: Astro-TE NN_3 Fam163a astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Fam163a (Mmus), Kcnq3 (Mmus), Kcnq1ot1 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Fam163a, Nr2f1, Kcnq1ot1. These cells are located in the Isocortex, Olfactory areas . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5225 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5225 Astro-TE NN_3" EXACT []
is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus)

[Term]
id: CL:4307046
name: Astro-TE NN_3 Zic4 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Ranbp3l (Mmus), Emx2os (Mmus), Zic4 (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Zic4. These cells are located in the Lateral septal complex, Isocortex, Olfactory areas , in or close to the regions: Lateral septal nucleus, rostral (rostroventral) part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5226 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5226 Astro-TE NN_3" EXACT []
is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus)

[Term]
id: CL:4307047
name: Astro-TE NN_3 Crym astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Crym (Mmus), Grin2c (Mmus). It is distinguished from other Astro-TE NN_3 cells by expression of Crym, Gabbr2. These cells are located in the Striatum dorsal region, Striatum ventral region , in or close to the regions: Nucleus accumbens, Caudoputamen . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5227 Astro-TE NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5227 Astro-TE NN_3" EXACT []
is_a: CL:4301593 ! Astro-TE NN_3 astrocyte (Mmus)

[Term]
id: CL:4307048
name: Astro-TE NN_4 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Gm29683 (Mmus), Slc39a12 (Mmus). It is distinguished from other Astro-TE NN cells by expression of Gm29683. These cells are located in the Cortical subplate, brain , in or close to the regions: Lateral amygdalar nucleus, external capsule . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5228 Astro-TE NN_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1164 Astro-TE NN_4" EXACT []
synonym: "5228 Astro-TE NN_4" EXACT []
is_a: CL:4300359 ! astrocyte of cerebrum (Mmus)

[Term]
id: CL:4307049
name: Astro-TE NN_5 Hs3st3a1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Thbs4 (Mmus), Hs3st3a1 (Mmus), Sfrp1 (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Hs3st3a1, Sfrp1. These cells are located in the Olfactory areas, brain , in or close to the regions: Anterior olfactory nucleus, corpus callosum, body, lateral ventricle, corpus callosum, anterior forceps . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5229 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5229 Astro-TE NN_5" EXACT []
is_a: CL:4301595 ! Astro-TE NN_5 astrocyte (Mmus)

[Term]
id: CL:4307050
name: Astro-TE NN_5 Adamts18 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Adamts18 (Mmus), Crym (Mmus). It is distinguished from other Astro-TE NN_5 cells by expression of Adamts18. These cells are located in the Lateral septal complex, Striatum dorsal region, brain , in or close to the regions: Nucleus accumbens, Caudoputamen, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5230 Astro-TE NN_5." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5230 Astro-TE NN_5" EXACT []
is_a: CL:4301595 ! Astro-TE NN_5 astrocyte (Mmus)

[Term]
id: CL:4307051
name: Astro-OLF NN_1 Greb1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gja1 (Mmus), Chrdl1 (Mmus), Ano1 (Mmus), Il33 (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Greb1, Il33. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5231 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5231 Astro-OLF NN_1" EXACT []
is_a: CL:4301596 ! Astro-OLF NN_1 astrocyte (Mmus)

[Term]
id: CL:4307052
name: Astro-OLF NN_1 Stk32a astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Prss23 (Mmus), Stk32a (Mmus). It is distinguished from other Astro-OLF NN_1 cells by expression of Stk32a. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5232 Astro-OLF NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5232 Astro-OLF NN_1" EXACT []
is_a: CL:4301596 ! Astro-OLF NN_1 astrocyte (Mmus)

[Term]
id: CL:4307053
name: Astro-OLF NN_2 Slc25a34 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Aqp4 (Mmus), Hs3st3a1 (Mmus), Slc25a34 (Mmus), C4b (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Slc25a34, C4b. These cells are located in the Olfactory areas, brain , in or close to the regions: Main olfactory bulb, outer plexiform layer, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5233 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5233 Astro-OLF NN_2" EXACT []
is_a: CL:4301597 ! Astro-OLF NN_2 astrocyte (Mmus)

[Term]
id: CL:4307054
name: Astro-OLF NN_2 Alk astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), Chrdl1 (Mmus), Sfrp1 (Mmus), Atp13a4 (Mmus). It is distinguished from other Astro-OLF NN_2 cells by expression of Alk, Atp13a4. These cells are located in the Olfactory areas , in or close to the regions: Anterior olfactory nucleus, Main olfactory bulb, granule layer, Main olfactory bulb, mitral layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5234 Astro-OLF NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5234 Astro-OLF NN_2" EXACT []
is_a: CL:4301597 ! Astro-OLF NN_2 astrocyte (Mmus)

[Term]
id: CL:4307055
name: Astro-OLF NN_3 Ecrg4 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Dipk1c (Mmus), Ecrg4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Ecrg4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5235 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5235 Astro-OLF NN_3" EXACT []
is_a: CL:4301598 ! Astro-OLF NN_3 astrocyte (Mmus)

[Term]
id: CL:4307056
name: Astro-OLF NN_3 Sfrp1 astrocyte (Mmus)
def: "A astrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of S1pr1 (Mmus), 6530411M01Rik (Mmus), Sfrp1 (Mmus), Aqp4 (Mmus). It is distinguished from other Astro-OLF NN_3 cells by expression of Sfrp1, Aqp4. These cells are located in the Olfactory areas , in or close to the regions: Main olfactory bulb, granule layer, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5236 Astro-OLF NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5236 Astro-OLF NN_3" EXACT []
is_a: CL:4301598 ! Astro-OLF NN_3 astrocyte (Mmus)

[Term]
id: CL:4307063
name: Tanycyte NN_1 Cnmd tanycyte of subfornical organ (Mmus)
def: "A tanycyte of subfornical organ of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cnmd (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Cnmd. These cells are located in the brain , in or close to the regions: choroid plexus, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5243 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Rationale for assigning this type to reference data: Mapping to tanycyte of subfornical organ based on spatial transcriptomics evidence. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5243 Tanycyte NN_1" EXACT []
is_a: CL:0008042 ! tanycyte of subfornical organ
is_a: CL:4301602 ! Tanycyte NN_1 tanycyte (Mmus)

[Term]
id: CL:4307064
name: Tanycyte NN_1 Glp1r tanycyte (Mmus)
def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C230072F16Rik (Mmus), Glp1r (Mmus). It is distinguished from other Tanycyte NN_1 cells by expression of Glp1r. These cells are located in the Hypothalamus, brain , in or close to the regions: Anteroventral periventricular nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5244 Tanycyte NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5244 Tanycyte NN_1" EXACT []
is_a: CL:4301602 ! Tanycyte NN_1 tanycyte (Mmus)

[Term]
id: CL:4307065
name: Tanycyte NN_2 Mylk3 alpha1-tanycyte (Mmus)
def: "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Dynlrb2 (Mmus), Mylk3 (Mmus), Sfta3-ps (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mylk3. It is glutamatergic (inferred from expression of Slc17a8). These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5245 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5245 Tanycyte NN_2" EXACT []
is_a: CL:1100001 ! secretory epithelial cell
is_a: CL:4042017 ! alpha1-tanycyte
is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus)
relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8"} ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:4307066
name: Tanycyte NN_2 Mroh5 alpha1-tanycyte (Mmus)
def: "A alpha1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc170 (Mmus), Nkx2-4 (Mmus), Dock8 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Mroh5. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, intermediate part, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5246 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5246 Tanycyte NN_2" EXACT []
is_a: CL:4042017 ! alpha1-tanycyte
is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus)

[Term]
id: CL:4307067
name: alpha2-tanycyte (Mmus)
def: "A alpha2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdzph1 (Mmus), Wdr63 (Mmus), Dscaml1 (Mmus), P3h2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Dscaml1, P3h2. These cells are located in the Hypothalamus , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5247 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5247 Tanycyte NN_2" EXACT []
is_a: CL:4042018 ! alpha2-tanycyte
is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus)

[Term]
id: CL:4307068
name: Tanycyte NN_2 Otx2 tanycyte (Mmus)
def: "A tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Ccdc146 (Mmus), Tbx3 (Mmus), Otx2 (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Otx2, Nkx2-4. These cells are located in the Hypothalamus, brain , in or close to the regions: Periventricular hypothalamic nucleus, posterior part, third ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5248 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5248 Tanycyte NN_2" EXACT []
is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus)

[Term]
id: CL:4307069
name: beta1-tancyte (Mmus)
def: "A beta1-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr50 (Mmus), Frzb (Mmus), Foxd2os (Mmus). It is distinguished from other Tanycyte NN_2 cells by expression of Col25a1, C230072F16Rik. These cells are located in the Hypothalamus, brain , in or close to the regions: third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5249 Tanycyte NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5249 Tanycyte NN_2" EXACT []
is_a: CL:4042019 ! beta1-tanycyte
is_a: CL:4301603 ! Tanycyte NN_2 tanycyte (Mmus)

[Term]
id: CL:4307070
name: beta-2 tanycyte (Mmus)
def: "A beta2-tanycyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Fndc3c1 (Mmus), Ecrg4 (Mmus). It is distinguished from other Tanycyte NN cells by expression of Ecrg4. These cells are located in the Hypothalamus, brain , in or close to the regions: Median eminence, third ventricle, Arcuate hypothalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5250 Tanycyte NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "1174 Tanycyte NN_3" EXACT []
synonym: "5250 Tanycyte NN_3" EXACT []
is_a: CL:4042020 ! beta2-tanycyte
is_a: CL:4300362 ! tanycyte (Mmus)

[Term]
id: CL:4307083
name: hypendemal cell (Mmus)
def: "A hypendymal cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Sspo (Mmus), Wfdc2 (Mmus). It is distinguished from other Astro-Epen cells by expression of Sspo, Wfdc2. These cells are located in the Midbrain, brain , in or close to the regions: third ventricle, posterior commissure, Subcommissural organ . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5263 Hypendymal NN_1." [doi:10.3389/fncel.2015.00480, https://doi.org/10.1038/s41586-023-06812-z]
comment: Rationale for assigning this type to reference data: Mapping of this cell set to the hypendemal cell type is supported by its location to the subcommisural organ (from spatial transcriptomics), its expression of Sspo and its general transcriptomic classification in a class (Astro-Epen) along with epdendymal cells, tanycytes and astrocytes. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="doi:10.3389/fncel.2015.00480"}
subset: human_subset
subset: mouse_subset
synonym: "1177 Hypendymal NN_1" EXACT []
synonym: "324 Hypendymal NN" EXACT []
synonym: "5263 Hypendymal NN_1" EXACT []
is_a: CL:4023181 ! hypendymal cell

[Term]
id: CL:4307084
name: CHOR NN_1 Tbc1d1 choroid plexus epithelial cell (Mmus)
def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Tbc1d1 (Mmus). It is distinguished from other CHOR NN cells by expression of Tbc1d1. These cells are located in the Cerebellum, brain , in or close to the regions: Paraflocculus, choroid plexus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5264 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5264 CHOR NN_1" EXACT []
is_a: CL:4301608 ! choroid plexus epithelial cell (Mmus)

[Term]
id: CL:4307085
name: CHOR NN_1 Slc17a8 choroid plexus epithelial cell (Mmus)
def: "A choroid plexus epithelial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 2900040C04Rik (Mmus), Slc17a8 (Mmus). It is distinguished from other CHOR NN cells by expression of Slc17a8. It is glutamatergic (inferred from expression of Slc17a8). These cells are located in the brain , in or close to the regions: choroid plexus, lateral ventricle . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5265 CHOR NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "5265 CHOR NN_1" EXACT []
is_a: CL:0000686 ! cerebrospinal fluid secreting cell
is_a: CL:4301608 ! choroid plexus epithelial cell (Mmus)
relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a8"} ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:4307086
name: OPC NN_1 Neil3 oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Mki67 (Mmus), Foxg1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Foxg1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5266 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5266 OPC NN_1" EXACT []
is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus)

[Term]
id: CL:4307087
name: OPC NN_1 Irx2 oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Pclaf (Mmus), Irx2 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Neil3, Irx2. These cells are located in the Cerebellum, brain, Midbrain, Pons, Medulla . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5267 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5267 OPC NN_1" EXACT []
is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus)

[Term]
id: CL:4307088
name: OPC NN_1 Mms22l oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Mms22l (Mmus), Top2a (Mmus). It is distinguished from other OPC NN_1 cells by expression of Mms22l, Foxg1, Top2a. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5268 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5268 OPC NN_1" EXACT []
is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus)

[Term]
id: CL:4307089
name: OPC NN_1 Col27a1 oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Col27a1. These cells are located in the Midbrain, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5269 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5269 OPC NN_1" EXACT []
is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus)

[Term]
id: CL:4307090
name: OPC NN_1 Rmi2 oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Olig1 (Mmus), Rmi2 (Mmus), Col27a1 (Mmus). It is distinguished from other OPC NN_1 cells by expression of Rmi2, Col27a1. These cells are located in the Hypothalamus, Midbrain, Pallidum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5270 OPC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5270 OPC NN_1" EXACT []
is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus)

[Term]
id: CL:4307091
name: OPC NN_2 oligodendrocyte precursor cell (Mmus)
def: "A oligodendrocyte precursor cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Pdgfra (Mmus), Cenpf (Mmus), Cenpa (Mmus). It is distinguished from other OPC NN cells by expression of Cenpa. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5271 OPC NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1180 OPC NN_2" EXACT []
synonym: "5271 OPC NN_2" EXACT []
is_a: CL:4300366 ! oligodendrocyte precursor cell (Mmus)

[Term]
id: CL:4307092
name: COP NN_1 Rgcc committed oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bmp4 (Mmus), Zfp36l1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, Plpp4. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5272 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5272 COP NN_1" EXACT []
is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus)

[Term]
id: CL:4307093
name: COP NN_1 9130019P16Rik committed oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Gp1bb (Mmus), Pdzd2 (Mmus), Plekhg1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Rgcc, 9130019P16Rik. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5273 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5273 COP NN_1" EXACT []
is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus)

[Term]
id: CL:4307094
name: COP NN_1 C1ql1 committed oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Gpr17 (Mmus), Bgn (Mmus), Gstp1 (Mmus), C1ql1 (Mmus). It is distinguished from other COP NN_1 cells by expression of C1ql1, Gstp1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5274 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5274 COP NN_1" EXACT []
is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus)

[Term]
id: CL:4307095
name: COP NN_1 Bmp4 committed oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Mob3b (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Mob3b. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5275 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5275 COP NN_1" EXACT []
is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus)

[Term]
id: CL:4307096
name: COP NN_1 Vwc2 committed oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rab32 (Mmus), Opalin (Mmus). It is distinguished from other COP NN_1 cells by expression of Vwc2, Opalin. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5276 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5276 COP NN_1" EXACT []
is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus)

[Term]
id: CL:4307097
name: COP NN_1 Cck committed oligodendrocyte precursor (Mmus)
def: "A committed oligodendrocyte precursor of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Bmp4 (Mmus), Cck (Mmus), Ptger1 (Mmus). It is distinguished from other COP NN_1 cells by expression of Bmp4, Cck, Ptger1. These cells are located in the Isocortex, Olfactory areas, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5277 COP NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5277 COP NN_1" EXACT []
is_a: CL:4301611 ! commited oligodendrocyte precursor (Mmus)

[Term]
id: CL:4307098
name: NFOL NN_2 9630013A20Rik newly formed oligodendrocyte (Mmus)
def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Grin2b (Mmus). It is distinguished from other NFOL NN_2 cells by expression of 9630013A20Rik, Grin2b. These cells are located in the Midbrain, Thalamus, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5278 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5278 NFOL NN_2" EXACT []
is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus)

[Term]
id: CL:4307099
name: NFOL NN_2 Dbx2 newly formed oligodendrocyte (Mmus)
def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Dbx2 (Mmus), Rassf10 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Dbx2, Rassf10. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5279 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5279 NFOL NN_2" EXACT []
is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus)

[Term]
id: CL:4307100
name: NFOL NN_2 Rgs16 newly formed oligodendrocyte (Mmus)
def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Rgs16 (Mmus), Rhbdl2 (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Rgs16, Rhbdl2. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5280 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5280 NFOL NN_2" EXACT []
is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus)

[Term]
id: CL:4307101
name: NFOL NN_2 Il23a newly formed oligodendrocyte (Mmus)
def: "A newly formed oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Piezo2 (Mmus), Ptprb (Mmus). It is distinguished from other NFOL NN_2 cells by expression of Il23a, Opalin, Ptprb. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5281 NFOL NN_2." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5281 NFOL NN_2" EXACT []
is_a: CL:4301612 ! newly formed oligodendrocyte (Mmus)

[Term]
id: CL:4307102
name: MFOL NN_3 Cxcl12 myelin-forming oligodendrocyte (Mmus)
def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Cxcl12 (Mmus), Efhd1 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Cxcl12, Efhd1. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5282 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5282 MFOL NN_3" EXACT []
is_a: CL:4301613 ! myelin-forming oligodendrocyte (Mmus)

[Term]
id: CL:4307103
name: MFOL NN_3 Il23a myelin-forming oligodendrocyte (Mmus)
def: "A myelin-forming oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of 9630013A20Rik (Mmus), Ppp1r14a (Mmus), Mroh3 (Mmus). It is distinguished from other MFOL NN_3 cells by expression of Il23a, Ppp1r14a. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5283 MFOL NN_3." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5283 MFOL NN_3" EXACT []
is_a: CL:4301613 ! myelin-forming oligodendrocyte (Mmus)

[Term]
id: CL:4307104
name: MOL NN_4 Plin3 mature myelinating oligodendrocyte (Mmus)
def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prr5l (Mmus), Hapln2 (Mmus), Enpp6 (Mmus), Grm7 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Plin3, Grm7. These cells are located in the Medulla, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5284 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5284 MOL NN_4" EXACT []
is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus)

[Term]
id: CL:4307105
name: MOL NN_4 Spock3 mature myelinating oligodendrocyte (Mmus)
def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn11 (Mmus), A230001M10Rik (Mmus), Spock3 (Mmus), Rhoj (Mmus). It is distinguished from other MOL NN_4 cells by expression of Spock3, Rhoj. These cells are located in the Midbrain, Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5285 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5285 MOL NN_4" EXACT []
is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus)

[Term]
id: CL:4307106
name: MOL NN_4 Art3 mature myelinating oligodendrocyte (Mmus)
def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Klk6 (Mmus), Dlc1 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Art3. These cells are located in the Medulla, Pons, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5286 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5286 MOL NN_4" EXACT []
is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus)

[Term]
id: CL:4307107
name: MOL NN_4 Il33 mature myelinating oligodendrocyte (Mmus)
def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Opalin (Mmus), Grm3 (Mmus), Gm5087 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Il33, Gm5087. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5287 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5287 MOL NN_4" EXACT []
is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus)

[Term]
id: CL:4307108
name: MOL NN_4 Sspo mature myelinating oligodendrocyte (Mmus)
def: "A mature myelinating oligodendrocyte of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mog (Mmus), Anln (Mmus), Gm32633 (Mmus). It is distinguished from other MOL NN_4 cells by expression of Sspo, Selenop. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5288 MOL NN_4." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5288 MOL NN_4" EXACT []
is_a: CL:4301614 ! mature myelinating oligodendrocyte (Mmus)

[Term]
id: CL:4307109
name: OEC NN_1 Adamts12 olfactory ensheathing cell (Mmus)
def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Cldn5 (Mmus), Adamts12 (Mmus). It is distinguished from other OEC cells by expression of Adamts12. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5289 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5289 OEC NN_1" EXACT []
is_a: CL:4301615 ! olfactory ensheathing cell (Mmus)

[Term]
id: CL:4307110
name: OEC NN_1 Gdpd4 olfactory ensheathing cell (Mmus)
def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Aqp1 (Mmus), Cldn5 (Mmus). It is distinguished from other OEC cells by expression of Gdpd4, Cldn5. These cells are located in the brain , in or close to the regions: olfactory nerve layer of main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5290 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5290 OEC NN_1" EXACT []
is_a: CL:4301615 ! olfactory ensheathing cell (Mmus)

[Term]
id: CL:4307111
name: OEC NN_1 A330076C08Rik olfactory ensheathing cell (Mmus)
def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Syk (Mmus). It is distinguished from other OEC cells by expression of A330076C08Rik. These cells are located in the Olfactory areas, brain , in or close to the regions: olfactory nerve layer of main olfactory bulb, Main olfactory bulb . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5291 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5291 OEC NN_1" EXACT []
is_a: CL:4301615 ! olfactory ensheathing cell (Mmus)

[Term]
id: CL:4307112
name: OEC NN_1 Rasgef1c olfactory ensheathing cell (Mmus)
def: "A olfactory ensheathing cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Apod (Mmus), Mybpc1 (Mmus), Rasgef1c (Mmus). It is distinguished from other OEC cells by expression of Rasgef1c. It is glutamatergic (inferred from expression of Slc17a7). These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5292 OEC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5292 OEC NN_1" EXACT []
is_a: CL:0000151 ! secretory cell
is_a: CL:4301615 ! olfactory ensheathing cell (Mmus)
relationship: RO:0002215 GO:0061535 {comment="Inferred to be glutamate secretion, neurotransmission based on expression of Slc17a7"} ! capable of glutamate secretion, neurotransmission

[Term]
id: CL:4307113
name: ABC NN_1 Pde11a arachnoid barrier cell (Mmus)
def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Pde11a (Mmus). It is distinguished from other ABC NN cells by expression of Pde11a. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5293 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5293 ABC NN_1" EXACT []
is_a: CL:4301616 ! arachnoid barrier cell (Mmus)

[Term]
id: CL:4307114
name: ABC NN_1 Dapl1 arachnoid barrier cell (Mmus)
def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Slc47a1 (Mmus), Dapl1 (Mmus). It is distinguished from other ABC NN cells by expression of Dapl1. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5294 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5294 ABC NN_1" EXACT []
is_a: CL:4301616 ! arachnoid barrier cell (Mmus)

[Term]
id: CL:4307115
name: ABC NN_1 Cubn arachnoid barrier cell (Mmus)
def: "A arachnoid barrier cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Prg4 (Mmus), Cubn (Mmus). It is distinguished from other ABC NN cells by expression of Cubn. These cells are located in the brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5295 ABC NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5295 ABC NN_1" EXACT []
is_a: CL:4301616 ! arachnoid barrier cell (Mmus)

[Term]
id: CL:4307132
name: microglial cell (Mmus)
def: "A microglial cell of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of C1qa (Mmus), Tmem119 (Mmus). It is distinguished from other Immune cells by expression of C1qa, Tmem119. These cells are located in the Isocortex, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5312 Microglia NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "1194 Microglia NN_1" EXACT []
synonym: "334 Microglia NN" EXACT []
synonym: "5312 Microglia NN_1" EXACT []
is_a: CL:0000129 ! microglial cell
relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus

[Term]
id: CL:4307133
name: BAM NN_1 Mrc1 border associated macrophage (Mmus)
def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus). It is distinguished from other BAM NN cells by expression of Mrc1, Pf4. These cells are located in the Medulla, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5313 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5313 BAM NN_1" EXACT []
is_a: CL:4301625 ! border associated macrophage (Mmus)

[Term]
id: CL:4307134
name: BAM NN_1 Fos border associated macrophage (Mmus)
def: "A border associated macrophage of the Mus musculus brain. It is distinguished from other cells in the brain by selective expression of Mrc1 (Mmus), Pf4 (Mmus), Fos (Mmus). It is distinguished from other BAM NN cells by expression of Fos. These cells are located in the Isocortex, Cerebellum, brain . Reference transcriptomic data for this type can be found in the dataset/taxonomy - Yao et al. (2023), Whole Mouse Brain in cell set Cluster:5314 BAM NN_1." [https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: mouse_subset
synonym: "5314 BAM NN_1" EXACT []
is_a: CL:4301625 ! border associated macrophage (Mmus)

[Term]
id: CL:4310083
name: GPin-BF cholinergic-GABAergic neuron (Primate)
def: "A GABA-Chol neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPin-BF Cholinergic GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "GPin-BF Cholinergic GABA" EXACT []
is_a: CL:0008061 ! GABA-Chol neuron

[Term]
id: CL:4310084
name: striatal LAMP5 CXCL14 GABAergic interneuron (Primate)
def: "A lamp5 GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:LAMP5-CXCL14 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of LAMP5 GABAergic neurons located in the striatum. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "CN LAMP5-CXCL14 GABA" EXACT []
synonym: "LAMP5" EXACT []
synonym: "LAMP5-CXCL14 GABA" EXACT []
is_a: CL:4023011 ! lamp5 GABAergic interneuron

[Term]
id: CL:4310085
name: striatal LAMP5 LHX6 GABAergic interneuron (Primate)
def: "A Lamp5 Lhx6 neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:LAMP5-LHX6 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of LAMP5 LHX6 GABAergic neurons located in the striatum. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "CN LAMP5-LHX6 GABA" EXACT []
synonym: "LAMP5-LHX6 GABA" EXACT []
is_a: CL:4042013 ! Lamp5 Lhx6 neuron

[Term]
id: CL:4310088
name: BF SKOR1 Glut glutamatergic neuron of the basal ganglia (Primate)
def: "A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:BF SKOR1 Glut." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "BF SKOR1 Glut" EXACT []
is_a: CL:4042040 ! glutamatergic neuron of the basal ganglia

[Term]
id: CL:4310093
name: arkypallidal neuron (Primate)
def: "A arkypallidal neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe MEIS2-SOX6 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2015.03.007, https://doi.org/10.1038/s41593-023-01368-7, https://doi.org/10.1523/JNEUROSCI.4662-14.2015]
comment: Rationale for assigning this type to reference data: Mapping to the arkypallidal neuron is based on location (GPe), expression of GAD1/2, FOXP2, MEIS2, and NPAS1 and lack of expression of canonical pallidal markers NKX2-1 and LHX6, SST and PV. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41593-023-01368-7", xref="https://doi.org/10.1016/j.neuron.2015.03.007", xref="https://doi.org/10.1523/JNEUROSCI.4662-14.2015"}
subset: human_subset
subset: mouse_subset
synonym: "CN MEIS2 GABA" EXACT []
synonym: "GPe MEIS2-SOX6 GABA" EXACT []
is_a: CL:0020010 ! arkypallidal neuron

[Term]
id: CL:4310094
name: prototypic neuron (Primate)
def: "A prototypic neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe SOX6-CTXND1 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2015.03.007]
comment: Rationale for assigning this type to reference data: Mapping to the general type of prototypic neuron is based on location (GPe) and expression of Nkx2-1. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.neuron.2015.03.007"}
subset: human_subset
subset: mouse_subset
synonym: "GPe SOX6-CTXND1 GABA" EXACT []
is_a: CL:0020009 ! prototypic neuron

[Term]
id: CL:4310095
name: GPi Core neuron (Primate)
def: "A internal globus pallidus core projecting neuron of the Primates brain. These cells are located in the internal segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPi Core." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2017.03.017, https://doi.org/10.1523/ENEURO.0208-22.2022]
comment: Rationale for assigning this type to reference data: Mapping to the general GPi core cell type is based on location (to GPi, nested inside GPi shell neurons), predicted neurotransmitter (GABA), and expression of Pvalb. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1523/ENEURO.0208-22.2022", xref="https://doi.org/10.1016/j.neuron.2017.03.017"}
subset: human_subset
subset: mouse_subset
synonym: "CN ONECUT1 GABA" EXACT []
synonym: "GPi Core" EXACT []
is_a: CL:0020003 ! internal globus pallidus core projecting neuron

[Term]
id: CL:4310096
name: GPi Shell neuron (Primate)
def: "A internal globus pallidus shell projection neuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus, internal segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPi Shell." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.neuron.2017.03.017, https://doi.org/10.1523/ENEURO.0208-22.2022]
comment: Rationale for assigning this type to reference data: Mapping to the general type GPi shell neuron (internal globus pallidus shell projection neuron) is based on soma location (to GPi & surrounding GPi core neurons), neurotransmitter (dual GABA-Glut), expression of sst, Sst,Tbr1,Slc17a6 and absence of Pvalb expression. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1523/ENEURO.0208-22.2022", xref="https://doi.org/10.1016/j.neuron.2017.03.017"}
subset: human_subset
synonym: "CN GABA-Glut" EXACT []
synonym: "GPi Shell" EXACT []
synonym: "Subpallium GABA-Glut" EXACT []
is_a: CL:0020004 ! internal globus pallidus shell projection neuron
relationship: RO:0002162 NCBITaxon:9443 ! in taxon Primates

[Term]
id: CL:4310100
name: GPe-NDB-SI LHX6-LHX8-GBX1 GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum, external segment of globus pallidus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:GPe-NDB-SI LHX6-LHX8-GBX1 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "GPe-NDB-SI LHX6-LHX8-GBX1 GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310104
name: Islands of Calleja granule cell (Primate)
def: "A Island of Calleja granule cell of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OT D1 ICj." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D1-ICj (Islands of Calleja)" EXACT []
synonym: "OT D1 ICj" EXACT []
synonym: "OT Granular GABA" EXACT []
is_a: CL:4030053 ! Islands of Calleja granule cell

[Term]
id: CL:4310109
name: SN-VTR CALB1 Dopa substantia nigra dopaminergic neuron (Primate)
def: "A substantia nigra dopaminergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR CALB1 Dopa." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41467-020-17876-0]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41467-020-17876-0"}
subset: human_subset
subset: mouse_subset
synonym: "SN-VTR CALB1 Dopa" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:4310110
name: SN EBF2 GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN EBF2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "SN EBF2 GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310111
name: SN-VTR GAD2 Dopa dopaminergic neuron (Primate)
def: "A dopaminergic neuron of the Primates brain. These cells are located in the striatum, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR GAD2 Dopa." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1101/2024.06.06.597807]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1101/2024.06.06.597807"}
subset: human_subset
subset: mouse_subset
synonym: "SN-VTR GAD2 Dopa" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:4310112
name: SN GATA3-PAX8 GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN GATA3-PAX8 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.3389/fnins.2022.976209]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.3389/fnins.2022.976209"}
subset: human_subset
subset: mouse_subset
synonym: "pSNpr" EXACT []
synonym: "SN GATA3-PAX8 GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310113
name: SN GATA3-PVALB GABA GABAergic neuron (Primate)
def: "A GABAergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN GATA3-PVALB GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.3389/fnins.2022.976209]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.3389/fnins.2022.976209"}
subset: human_subset
subset: mouse_subset
synonym: "aSNpr" EXACT []
synonym: "SN GATA3-PVALB GABA" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:4310114
name: SN SEMA5A GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum, subthalamic nucleus, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN SEMA5A GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "SN SEMA5A GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310115
name: SN SOX6 Dopa substantia nigra dopaminergic neuron (Primate)
def: "A substantia nigra dopaminergic neuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN SOX6 Dopa." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41593-022-01061-1]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41593-022-01061-1"}
subset: human_subset
subset: mouse_subset
synonym: "SN SOX6 Dopa" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:4310117
name: SN-VTR-HTH GATA3-TCF7L2 GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:SN-VTR-HTH GATA3-TCF7L2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "SN-VTR-HTH GATA3-TCF7L2 GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310118
name: STH PVALB-PITX2 Glut glutamatergic neuron of the basal ganglia (Primate)
def: "A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the subthalamic nucleus . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STH PVALB-PITX2 Glut." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-023-06812-z]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-023-06812-z"}
subset: human_subset
subset: mouse_subset
synonym: "STH PVALB-PITX2 Glut" EXACT []
is_a: CL:4042040 ! glutamatergic neuron of the basal ganglia

[Term]
id: CL:4310120
name: striatal pthlh-expressing interneuron (Primate)
def: "A striatal pthlh-expressing interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR FS PTHLH-PVALB GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.celrep.2018.07.053]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.celrep.2018.07.053"}
subset: human_subset
subset: mouse_subset
synonym: "FS" EXACT []
synonym: "Pvalb Pthlh" EXACT []
synonym: "STR FS PTHLH-PVALB GABA" EXACT []
is_a: CL:4042023 ! striatal pthlh-expressing interneuron

[Term]
id: CL:4310121
name: striatal SST-LYPD6-RSPO2 GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR LYPD6-RSPO2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STR LYPD6-RSPO2 GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310122
name: striatal SST-ADARB2 GABAergic interneuron (Primate)
def: "A sst GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-ADARB2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STR SST GABA" EXACT []
synonym: "STR SST-ADARB2 GABA" EXACT []
is_a: CL:4023017 ! sst GABAergic interneuron

[Term]
id: CL:4310123
name: striatal SST-CHODL GABAergic interneuron (Primate)
def: "A sst chodl GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-CHODL GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-020-2874-8]
comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of SST CHODL GABAergic neurons located in the striatum. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-020-2874-8"}
subset: human_subset
subset: mouse_subset
synonym: "LTS" EXACT []
synonym: "Sst Chodl" EXACT []
synonym: "STR SST-CHODL GABA" EXACT []
is_a: CL:4023121 ! sst chodl GABAergic interneuron

[Term]
id: CL:4310124
name: striatal SST-RSPO2 GABAergic interneuron (Primate)
def: "A sst GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR SST-RSPO2 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STR SST-RSPO2 GABA" EXACT []
is_a: CL:4023017 ! sst GABAergic interneuron

[Term]
id: CL:4310125
name: STR TAC3-PLPP4 GABA TAC3-positive striatal interneuron (Primate)
def: "A TAC3-positive striatal interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR TAC3-PLPP4 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-020-2874-8]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-020-2874-8"}
subset: human_subset
subset: mouse_subset
synonym: "LHX6 TAC3" EXACT []
synonym: "STR TAC3-PLPP4 GABA" EXACT []
is_a: CL:4042001 ! TAC3-positive striatal interneuron

[Term]
id: CL:4310126
name: STR-BF TAC3-PLPP4-LHX8 GABA TAC3-positive striatal interneuron (Primate)
def: "A TAC3-positive striatal interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR-BF TAC3-PLPP4-LHX8 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STR-BF TAC3-PLPP4-LHX8 GABA" EXACT []
is_a: CL:4042001 ! TAC3-positive striatal interneuron

[Term]
id: CL:4310127
name: striatal VIP GABAergic interneuron (Primate)
def: "A VIP GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:VIP GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1038/s41586-020-2874-8]
comment: Based on annotation transfer evidence with MapMyCells, this may not represent a transcriptomicallly distinct cell type, but rather the population of VIP GABAergic neurons located in the striatum. Rationale for assigning this type to reference data: Mapping to the general type VIP GABAergic neuron is supported by MapMyCells heirarchical annotation transfer mapping to 046 Vip Gaba in the whole mouse brain taxonomy v1. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1038/s41586-020-2874-8"}
subset: human_subset
subset: mouse_subset
synonym: "CN VIP GABA" EXACT []
synonym: "VIP" EXACT []
synonym: "VIP GABA" EXACT []
is_a: CL:4023016 ! VIP GABAergic interneuron

[Term]
id: CL:4310128
name: STRd cholinergic-GABAergic neuron (Primate)
def: "A dorso-striatal cholinergic-GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd Cholinergic GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STRd Cholinergic GABA" EXACT []
is_a: CL:0020007 ! dorso-striatal cholinergic-GABAergic neuron

[Term]
id: CL:4310129
name: STRd D1 Matrix medium spiny neuron (Primate)
def: "A matrix D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D1 Matrix MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D1-Matrix" EXACT []
synonym: "STRd D1 Matrix MSN" EXACT []
is_a: CL:4030043 ! matrix D1 medium spiny neuron

[Term]
id: CL:4310130
name: striosomal D1 medium spiny neuron (Primate)
def: "A striosomal D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D1 Striosome MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D1-Striosome" EXACT []
synonym: "STRd D1 Striosome MSN" EXACT []
is_a: CL:4030048 ! striosomal D1 medium spiny neuron

[Term]
id: CL:4310131
name: STRd D1/D2-hybrid medium spiny neuron (Primate)
def: "A D1/D2-hybrid medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR D1D2 Hybrid MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D1/D2 Hybrid" EXACT []
synonym: "STR D1D2 Hybrid MSN" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:4310132
name: STRd D2 Matrix medium spiny neuron (Primate)
def: "A matrix D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 Matrix MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D2-Matrix" EXACT []
synonym: "STRd D2 Matrix MSN" EXACT []
is_a: CL:4030047 ! matrix D2 medium spiny neuron

[Term]
id: CL:4310133
name: STRd D2 Striomat hybrid medium spiny neuron (Primate)
def: "A indirect pathway medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 StrioMat Hybrid MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STRd D2 StrioMat Hybrid MSN" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CL:4310134
name: striosomal D2 medium spiny neuron (Primate)
def: "A striosomal D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRd D2 Striosome MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D2-Striosome" EXACT []
synonym: "STRd D2 Striosome MSN" EXACT []
is_a: CL:4030049 ! striosomal D2 medium spiny neuron

[Term]
id: CL:4310135
name: STR cholinergic-GABAergic neuron (Primate)
def: "A striatal cholinergic-GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STR Cholinergic GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Despite the name, this type is not a parent type to STRd cholinergic-GABAergic neuron (Primate), but is instead a transcriptomically distinct sibling. Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "STR Cholinergic GABA" EXACT []
is_a: CL:0020008 ! striatal cholinergic-GABAergic neuron

[Term]
id: CL:4310136
name: STRv D1 medium spiny neuron (Primate)
def: "A nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D1 MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D1-Shell/OT" EXACT []
synonym: "STRv D1 MSN" EXACT []
is_a: CL:4030051 ! nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron

[Term]
id: CL:4310137
name: STRv D1-NUDAP medium spiny neuron (Primate)
def: "A D1-NUDAP medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D1 NUDAP MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D1-NUDAP" EXACT []
synonym: "STRv D1 NUDAP MSN" EXACT []
is_a: CL:4030054 ! D1-NUDAP medium spiny neuron

[Term]
id: CL:4310138
name: STRv D2 medium spiny neuron (Primate)
def: "A nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:STRv D2 MSN." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/, https://doi.org/10.1016/j.cub.2021.10.015]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions. {xref="https://doi.org/10.1016/j.cub.2021.10.015"}
subset: human_subset
subset: mouse_subset
synonym: "D2-Shell/OT" EXACT []
synonym: "STRv D2 MSN" EXACT []
is_a: CL:4030052 ! nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron

[Term]
id: CL:4310143
name: ZI-HTH GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:ZI-HTH GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "ZI-HTH GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310144
name: VTR-HTH Glut glutamatergic neuron of the basal ganglia (Primate)
def: "A glutamatergic neuron of the basal ganglia of the Primates brain. These cells are located in the striatum, subthalamic nucleus, substantia nigra . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:VTR-HTH Glut." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "F M Glut" EXACT []
synonym: "VTR-HTH Glut" EXACT []
is_a: CL:4042040 ! glutamatergic neuron of the basal ganglia

[Term]
id: CL:4310145
name: AMY-SLEA-BNST D1 GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:AMY-SLEA-BNST D1 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "AMY-SLEA-BNST D1 GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310146
name: AMY-SLEA-BNST GABA GABAergic interneuron (Primate)
def: "A GABAergic interneuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:AMY-SLEA-BNST GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "AMY-SLEA-BNST GABA" EXACT []
is_a: CL:0011005 ! GABAergic interneuron

[Term]
id: CL:4310147
name: OB Dopa-GABA neuron (Primate)
def: "A OB-Dopa-GABA of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OB Dopa-GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "OB Dopa-GABA" EXACT []
is_a: CL:0020006 ! OB-Dopa-GABA

[Term]
id: CL:4310148
name: OB FRMD7 GABA GABAergic neuron (Primate)
def: "A GABAergic neuron of the Primates brain. These cells are located in the striatum . Reference transcriptomic data for this type can be found in the dataset/taxonomy - HMBA Basal Ganglia Consensus Taxonomy in cell set Group:OB FRMD7 GABA." [https://alleninstitute.github.io/HMBA_BasalGanglia_Consensus_Taxonomy/]
comment: Location is inferred from registration of MerFish Data. Registration may be inaccurate, giving misleading location to adjacent anatomical regions.
subset: human_subset
subset: mouse_subset
synonym: "OB FRMD7 GABA" EXACT []
is_a: CL:0000000 ! cell

[Term]
id: CLM:1000043
name: NS forest marker set of pulmonary neuroendocrine cell (Human lung).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100604 ! has part CHGA
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000134443 ! has part GRP

[Term]
id: CLM:1000056
name: NS forest marker set of tracheobronchial smooth muscle cell (Human lung).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000107796 ! has part ACTA2
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000149591 ! has part TAGLN

[Term]
id: CLM:1000074
name: NS forest marker set of lamp5 GABAergic interneuron (Human neocortex).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000157404 ! has part KIT
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000235665 ! has part LINC00298

[Term]
id: CLM:1000075
name: NS forest marker set of Lamp5 Lhx6 neuron (Human neocortex).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000125869 ! has part LAMP5
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000154080 ! has part CHST9

[Term]
id: CLM:1000082
name: NS forest marker set of sst GABAergic interneuron (Human neocortex).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000114805 ! has part PLCH1
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000157005 ! has part SST

[Term]
id: CLM:1000083
name: NS forest marker set of sst chodl GABAergic interneuron (Human neocortex).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000122585 ! has part NPY

[Term]
id: CLM:1000085
name: NS forest marker set of VIP GABAergic interneuron (Human neocortex).
is_a: SO:0001260 ! sequence_collection
relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000146469 ! has part VIP

[Term]
id: GO:0000001
name: mitochondrion inheritance
namespace: biological_process
def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
synonym: "mitochondrial inheritance" EXACT []
is_a: GO:0048308 ! organelle inheritance
is_a: GO:0048311 ! mitochondrion distribution
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: GOREL:0002003 GO:0005739 ! results in distribution of mitochondrion
relationship: GOREL:0002003 GO:0005739 ! results in distribution of mitochondrion

[Term]
id: GO:0000003
name: obsolete reproduction
namespace: biological_process
def: "OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is that this term is equivalent to reproductive process.
synonym: "reproductive physiological process" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0000011
name: vacuole inheritance
namespace: biological_process
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: GOREL:0002003 GO:0005773 ! results in distribution of vacuole
relationship: GOREL:0002003 GO:0005773 ! results in distribution of vacuole

[Term]
id: GO:0000045
name: autophagosome assembly
namespace: biological_process
def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]
synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "autophagic vacuole formation" RELATED [GOC:mah]
synonym: "autophagosome biosynthesis" EXACT []
synonym: "autophagosome formation" EXACT []
synonym: "PAS formation" NARROW []
is_a: GO:0070925 ! organelle assembly
is_a: GO:1905037 ! autophagosome organization
relationship: BFO:0000051 GO:0019778 ! has part Atg12 activating enzyme activity
relationship: BFO:0000051 GO:0019786 ! has part protein-phosphatidylethanolamide deconjugating activity
relationship: BFO:0000051 GO:0061651 ! has part Atg12 conjugating enzyme activity
relationship: BFO:0000051 GO:0061660 ! has part Atg12 ligase activity
relationship: BFO:0000051 GO:1904745 ! has part Atg1/ULK1 kinase complex assembly

[Term]
id: GO:0000048
name: peptidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme." [PMID:11433365, PMID:9242921]
xref: EC:2.3.2.12
xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
xref: Reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA"
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140101 ! catalytic activity, acting on a tRNA

[Term]
id: GO:0000049
name: tRNA binding
namespace: molecular_function
def: "Binding to a transfer RNA." [GOC:ai]
synonym: "base pairing with tRNA" NARROW []
xref: Reactome:R-HSA-2408509 "Sec-tRNA(Sec) binds to EEFSEC:GTP"
is_a: GO:0003723 ! RNA binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:17843 ! has primary input
relationship: RO:0004009 CHEBI:17843 ! has primary input

[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
subset: goslim_pombe
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
xref: Reactome:R-HSA-2500257 "Resolution of Sister Chromatid Cohesion"
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: BFO:0000050 GO:0140014 ! part of mitotic nuclear division
relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
synonym: "Golgi apparatus membrane" EXACT []
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus
relationship: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_pombe
synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton
relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
intersection_of: GO:0005694 ! chromosome
intersection_of: BFO:0000050 GO:0005634 ! part of nucleus
relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen

[Term]
id: GO:0000262
name: mitochondrial chromosome
namespace: cellular_component
def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]
synonym: "mitochondrial DNA" NARROW []
synonym: "mitochondrial genome" RELATED []
synonym: "mtDNA" NARROW []
xref: NIF_Subcellular:sao1186327184
is_a: GO:0005694 ! chromosome
intersection_of: GO:0005694 ! chromosome
intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion
relationship: BFO:0000050 GO:0042645 ! part of mitochondrial nucleoid

[Term]
id: GO:0000266
name: mitochondrial fission
namespace: biological_process
def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
synonym: "mitochondrial division" EXACT []
synonym: "mitochondrial proliferation" RELATED []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: GOREL:0002004 GO:0005739 ! results in fission of mitochondrion
relationship: GOREL:0002004 GO:0005739 ! results in fission of mitochondrion

[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators]
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18154 ! has primary output polysaccharide
relationship: RO:0004008 CHEBI:18154 ! has primary output polysaccharide

[Term]
id: GO:0000272
name: polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]
synonym: "multicellular organismal polysaccharide catabolic process" NARROW []
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide

[Term]
id: GO:0000278
name: mitotic cell cycle
namespace: biological_process
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194]
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_yeast
synonym: "mitosis" RELATED []
xref: Reactome:R-HSA-69278 "Cell Cycle, Mitotic"
xref: Wikipedia:Mitosis
is_a: GO:0007049 ! cell cycle
intersection_of: GO:0007049 ! cell cycle
intersection_of: BFO:0000051 GO:0140014 ! has part mitotic nuclear division
relationship: BFO:0000051 GO:0140014 ! has part mitotic nuclear division

[Term]
id: GO:0000279
name: M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M-phase" EXACT []
xref: Wikipedia:M_phase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: GOREL:0002004 GO:0005634 ! results in fission of nucleus
relationship: GOREL:0002004 GO:0005634 ! results in fission of nucleus

[Term]
id: GO:0000302
name: response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
synonym: "response to active oxygen species" EXACT []
synonym: "response to AOS" EXACT []
synonym: "response to reactive oxidative species" EXACT []
synonym: "response to reactive oxygen intermediate" EXACT []
synonym: "response to ROI" EXACT []
synonym: "response to ROS" EXACT []
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:26523 ! has primary input reactive oxygen species
relationship: RO:0004009 CHEBI:26523 ! has primary input reactive oxygen species

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: BFO:0000050 GO:0043226 ! part of organelle
relationship: BFO:0000050 GO:0043226 ! part of organelle

[Term]
id: GO:0000323
name: lytic vacuole
namespace: cellular_component
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000740
name: nuclear membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane
relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane

[Term]
id: GO:0000741
name: karyogamy
namespace: biological_process
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048284 ! organelle fusion
intersection_of: GO:0048284 ! organelle fusion
intersection_of: RO:0012008 GO:0005634 ! results in fusion of nucleus
relationship: BFO:0000050 GO:0006997 ! part of nucleus organization
relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus

[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
is_a: GO:0006949 ! syncytium formation
is_a: GO:0140253 ! cell-cell fusion
intersection_of: GO:0006949 ! syncytium formation
intersection_of: BFO:0000051 GO:0045026 ! has part plasma membrane fusion

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
synonym: "chromosome scaffold" RELATED []
synonym: "cytoplasmic chromatin" NARROW []
synonym: "nuclear chromatin" NARROW []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005694 ! part of chromosome

[Term]
id: GO:0000791
name: euchromatin
namespace: cellular_component
def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]
synonym: "nuclear euchromatin" RELATED []
synonym: "transcriptionally active chromatin" EXACT []
xref: NIF_Subcellular:sao445485807
xref: Wikipedia:Euchromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]
synonym: "nuclear heterochromatin" NARROW []
synonym: "transcriptionally inactive chromatin" EXACT []
synonym: "transcriptionally silent chromatin" EXACT []
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000803
name: sex chromosome
namespace: cellular_component
def: "A chromosome involved in sex determination." [GOC:elh]
is_a: GO:0005694 ! chromosome
relationship: RO:0002216 GO:0007530 ! capable of part of sex determination

[Term]
id: GO:0000819
name: sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0000902
name: cell morphogenesis
namespace: biological_process
def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell
relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell

[Term]
id: GO:0000957
name: mitochondrial RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
xref: Reactome:R-HSA-9836573 "Mitochondrial RNA degradation"
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006401 ! RNA catabolic process
intersection_of: GO:0006401 ! RNA catabolic process
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion

[Term]
id: GO:0000959
name: mitochondrial RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0016070 ! RNA metabolic process
intersection_of: GO:0016070 ! RNA metabolic process
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0000960
name: regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000957 ! regulates mitochondrial RNA catabolic process
relationship: RO:0002211 GO:0000957 ! regulates mitochondrial RNA catabolic process

[Term]
id: GO:0000961
name: negative regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:1902369 ! negative regulation of RNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000957 ! negatively regulates mitochondrial RNA catabolic process
relationship: RO:0002212 GO:0000957 ! negatively regulates mitochondrial RNA catabolic process

[Term]
id: GO:0000962
name: positive regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000957 ! positively regulates mitochondrial RNA catabolic process
relationship: RO:0002213 GO:0000957 ! positively regulates mitochondrial RNA catabolic process

[Term]
id: GO:0001101
name: response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "response to acid" BROAD []
synonym: "response to acid anion" RELATED []
synonym: "response to oxoanion" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0001402
name: signal transduction involved in filamentous growth
namespace: biological_process
def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395]
synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED []
synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: BFO:0000050 GO:0030447 ! part of filamentous growth
relationship: BFO:0000050 GO:0030447 ! part of filamentous growth

[Term]
id: GO:0001501
name: skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system
relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria
relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal system

[Term]
id: GO:0001503
name: ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0032501 ! multicellular organismal process
intersection_of: GO:0032501 ! multicellular organismal process
intersection_of: RO:0002297 UBERON:0001474 ! results in formation of bone element
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002297 UBERON:0001474 ! results in formation of bone element

[Term]
id: GO:0001507
name: acetylcholine catabolic process in synaptic cleft
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai]
synonym: "acetylcholine breakdown in synaptic cleft" EXACT []
synonym: "acetylcholine degradation in synaptic cleft" EXACT []
is_a: GO:0006581 ! acetylcholine catabolic process
intersection_of: GO:0006581 ! acetylcholine catabolic process
intersection_of: BFO:0000066 GO:0043083 ! occurs in synaptic cleft
relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic
relationship: BFO:0000066 GO:0043083 ! occurs in synaptic cleft

[Term]
id: GO:0001508
name: action potential
namespace: biological_process
def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0001525
name: angiogenesis
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
xref: Wikipedia:Angiogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel
relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis
relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel

[Term]
id: GO:0001539
name: cilium or flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "ciliary or bacterial-type flagellar motility" RELATED []
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0001555
name: oocyte growth
namespace: biological_process
def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 CL:0000023 ! results in growth of oocyte
relationship: BFO:0000050 GO:0048599 ! part of oocyte development
relationship: RO:0002343 CL:0000023 ! results in growth of oocyte

[Term]
id: GO:0001556
name: oocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000023 ! results in maturation of oocyte
relationship: BFO:0000050 GO:0048599 ! part of oocyte development
relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte

[Term]
id: GO:0001558
name: regulation of cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016049 ! regulates cell growth
relationship: RO:0002211 GO:0016049 ! regulates cell growth

[Term]
id: GO:0001560
name: regulation of cell growth by extracellular stimulus
namespace: biological_process
def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "interpretation of external signals that regulate cell growth" EXACT []
synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT []
synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT []
synonym: "regulation of growth by exogenous signal" EXACT []
synonym: "regulation of growth by exogenous stimuli" EXACT []
synonym: "regulation of growth by exogenous stimulus" EXACT []
synonym: "regulation of growth by external signal" EXACT []
synonym: "regulation of growth by external stimuli" EXACT []
synonym: "regulation of growth by external stimulus" EXACT []
is_a: GO:0001558 ! regulation of cell growth
intersection_of: GO:0001558 ! regulation of cell growth
intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus
relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus

[Term]
id: GO:0001568
name: blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel
relationship: BFO:0000050 GO:0001944 ! part of vasculature development
relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel

[Term]
id: GO:0001569
name: branching involved in blood vessel morphogenesis
namespace: biological_process
def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "patterning of blood vessels" BROAD [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis
relationship: BFO:0000050 GO:0001525 ! part of angiogenesis

[Term]
id: GO:0001570
name: vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel
relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis
relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel

[Term]
id: GO:0001578
name: microtubule bundle formation
namespace: biological_process
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: RO:0000057 GO:0005874 ! has participant microtubule
relationship: RO:0002297 GO:0097427 ! results in formation of microtubule bundle

[Term]
id: GO:0001653
name: peptide receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
synonym: "endogenous peptide receptor activity" NARROW []
synonym: "exogenous peptide receptor activity" NARROW []
is_a: GO:0038023 ! signaling receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: BFO:0000051 GO:0042277 ! has part peptide binding
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion

[Term]
id: GO:0001654
name: eye development
namespace: biological_process
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye
relationship: BFO:0000050 GO:0150063 ! part of visual system development
relationship: RO:0002296 UBERON:0000970 ! results in development of eye

[Term]
id: GO:0001659
name: temperature homeostasis
namespace: biological_process
def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0001664
name: G protein-coupled receptor binding
namespace: molecular_function
def: "Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]
synonym: "G protein coupled receptor binding" EXACT []
synonym: "G protein coupled receptor ligand" NARROW []
synonym: "G-protein coupled receptor binding" EXACT [GOC:bf]
synonym: "G-protein-coupled receptor ligand" NARROW []
xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer"
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0001666
name: response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to intermittent hypoxia" NARROW []
synonym: "response to lowered oxygen tension" EXACT []
synonym: "response to sustained hypoxia" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0001667
name: ameboidal-type cell migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
comment: Note that this term refers to a mode of migration rather than to any particular cell type.
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: BFO:0000050 CL:0000021 ! part of female germ cell
relationship: BFO:0000050 CL:0000021 ! part of female germ cell

[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
namespace: biological_process
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex
relationship: BFO:0000050 GO:0006413 ! part of translational initiation
relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex

[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching
relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta

[Term]
id: GO:0001701
name: in utero embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development
relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria <mammals>

[Term]
id: GO:0001704
name: formation of primary germ layer
namespace: biological_process
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000923 ! results in formation of germ layer
relationship: BFO:0000050 GO:0007369 ! part of gastrulation
relationship: RO:0002297 UBERON:0000923 ! results in formation of germ layer

[Term]
id: GO:0001705
name: ectoderm formation
namespace: biological_process
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000924 ! results in formation of ectoderm
relationship: BFO:0000050 GO:0007398 ! part of ectoderm development
relationship: RO:0002297 UBERON:0000924 ! results in formation of ectoderm

[Term]
id: GO:0001706
name: endoderm formation
namespace: biological_process
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
xref: Reactome:R-HSA-9823730 "Formation of definitive endoderm"
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000925 ! results in formation of endoderm
relationship: BFO:0000050 GO:0007492 ! part of endoderm development
relationship: RO:0002297 UBERON:0000925 ! results in formation of endoderm

[Term]
id: GO:0001707
name: mesoderm formation
namespace: biological_process
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000926 ! results in formation of mesoderm
relationship: BFO:0000050 GO:0048332 ! part of mesoderm morphogenesis
relationship: RO:0002297 UBERON:0000926 ! results in formation of mesoderm

[Term]
id: GO:0001739
name: sex chromatin
namespace: cellular_component
def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732]
is_a: GO:0000792 ! heterochromatin
intersection_of: GO:0000792 ! heterochromatin
intersection_of: BFO:0000050 GO:0000803 ! part of sex chromosome
relationship: BFO:0000050 GO:0000803 ! part of sex chromosome

[Term]
id: GO:0001743
name: lens placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
synonym: "optic placode formation" RELATED []
is_a: GO:0060788 ! ectodermal placode formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003073 ! results in formation of lens placode
relationship: BFO:0000050 GO:0048598 ! part of embryonic morphogenesis
relationship: RO:0002297 UBERON:0003073 ! results in formation of lens placode

[Term]
id: GO:0001745
name: compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye
relationship: BFO:0000050 GO:0048749 ! part of compound eye development
relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye

[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell
relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis
relationship: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell

[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell
relationship: BFO:0000050 GO:0048592 ! part of eye morphogenesis
relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell

[Term]
id: GO:0001755
name: neural crest cell migration
namespace: biological_process
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0090497 ! mesenchymal cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell
relationship: BFO:0000050 GO:0014032 ! part of neural crest cell development
relationship: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell

[Term]
id: GO:0001756
name: somitogenesis
namespace: biological_process
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]
xref: Reactome:R-HSA-9824272 "Somitogenesis"
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0035282 ! segmentation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002329 ! results in formation of somite
relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development
relationship: BFO:0000050 GO:0061053 ! part of somite development
relationship: RO:0002297 UBERON:0002329 ! results in formation of somite

[Term]
id: GO:0001763
name: morphogenesis of a branching structure
namespace: biological_process
def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001764
name: neuron migration
namespace: biological_process
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
synonym: "neuron chemotaxis" EXACT []
synonym: "neuron guidance" RELATED []
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000540 ! results in movement of neuron
relationship: BFO:0000050 GO:0048699 ! part of generation of neurons
relationship: RO:0002565 CL:0000540 ! results in movement of neuron

[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
namespace: biological_process
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte
relationship: BFO:0000050 GO:0046649 ! part of lymphocyte activation
relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte

[Term]
id: GO:0001768
name: establishment of T cell polarity
namespace: biological_process
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: BFO:0000050 GO:0042110 ! part of T cell activation
relationship: BFO:0000066 CL:0000084 ! occurs in T cell

[Term]
id: GO:0001773
name: myeloid dendritic cell activation
namespace: biological_process
def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell
relationship: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell

[Term]
id: GO:0001774
name: microglial cell activation
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
is_a: GO:0002269 ! leukocyte activation involved in inflammatory response
is_a: GO:0042116 ! macrophage activation
is_a: GO:0061900 ! glial cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000129 ! has primary input microglial cell
relationship: RO:0004009 CL:0000129 ! has primary input microglial cell

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0032501 ! multicellular organismal process
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte

[Term]
id: GO:0001777
name: T cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000050 GO:0042592 ! part of homeostatic process
intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell
relationship: BFO:0000050 GO:0043029 ! part of T cell homeostasis

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cytokine biosynthetic process" NARROW []
synonym: "cytokine metabolic process" NARROW []
synonym: "cytokine secretion" NARROW []
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interferon secretion" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0010467 ! gene expression
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001817
name: regulation of cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "regulation of cytokine anabolism" EXACT []
synonym: "regulation of cytokine biosynthesis" EXACT []
synonym: "regulation of cytokine biosynthetic process" NARROW []
synonym: "regulation of cytokine formation" EXACT []
synonym: "regulation of cytokine secretion" NARROW []
synonym: "regulation of cytokine synthesis" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001816 ! regulates cytokine production
relationship: RO:0002211 GO:0001816 ! regulates cytokine production

[Term]
id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "down regulation of cytokine biosynthetic process" EXACT []
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine biosynthetic process" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine biosynthetic process" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine biosynthetic process" NARROW []
synonym: "inhibition of cytokine production" NARROW []
synonym: "negative regulation of cytokine anabolism" EXACT []
synonym: "negative regulation of cytokine biosynthesis" EXACT []
synonym: "negative regulation of cytokine biosynthetic process" NARROW []
synonym: "negative regulation of cytokine formation" EXACT []
synonym: "negative regulation of cytokine secretion" NARROW []
synonym: "negative regulation of cytokine synthesis" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001816 ! negatively regulates cytokine production
relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production

[Term]
id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "activation of cytokine production" NARROW []
synonym: "positive regulation of cytokine biosynthetic process" NARROW []
synonym: "positive regulation of cytokine secretion" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001816 ! positively regulates cytokine production
relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production

[Term]
id: GO:0001820
name: serotonin secretion
namespace: biological_process
def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
synonym: "serotonin release" RELATED [GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0023061 ! signal release
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:350546 ! has primary input

[Term]
id: GO:0001824
name: blastocyst development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
synonym: "blastula development" RELATED []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst
relationship: BFO:0000050 GO:0001701 ! part of in utero embryonic development
relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst

[Term]
id: GO:0001825
name: blastocyst formation
namespace: biological_process
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
synonym: "blastula formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000358 ! results in formation of blastocyst
relationship: BFO:0000050 GO:0001824 ! part of blastocyst development
relationship: RO:0002297 UBERON:0000358 ! results in formation of blastocyst

[Term]
id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell
relationship: BFO:0000050 GO:0001825 ! part of blastocyst formation
relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell

[Term]
id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell
relationship: BFO:0000050 GO:0001825 ! part of blastocyst formation
relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell

[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell
relationship: BFO:0000050 GO:0001829 ! part of trophectodermal cell differentiation
relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectodermal cell

[Term]
id: GO:0001832
name: blastocyst growth
namespace: biological_process
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
synonym: "blastula growth" RELATED []
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst
relationship: BFO:0000050 GO:0001824 ! part of blastocyst development
relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst

[Term]
id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell
relationship: BFO:0000050 GO:0001832 ! part of blastocyst growth
relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell

[Term]
id: GO:0001834
name: trophectodermal cell proliferation
namespace: biological_process
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell
relationship: BFO:0000050 GO:0001832 ! part of blastocyst growth
relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell

[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
xref: Reactome:R-HSA-9758919 "Epithelial-Mesenchymal Transition (EMT) during gastrulation"
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell
intersection_of: RO:0004009 CL:0000066 ! has primary input epithelial cell
relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell

[Term]
id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0072175 ! epithelial tube formation
relationship: BFO:0000050 GO:0016331 ! part of morphogenesis of embryonic epithelium

[Term]
id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate
relationship: BFO:0000050 GO:0001840 ! part of neural plate development
relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate

[Term]
id: GO:0001840
name: neural plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate
relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development
relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate

[Term]
id: GO:0001841
name: neural tube formation
namespace: biological_process
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001049 ! results in formation of neural tube
relationship: BFO:0000050 GO:0021915 ! part of neural tube development
relationship: RO:0002297 UBERON:0001049 ! results in formation of neural tube

[Term]
id: GO:0001842
name: neural fold formation
namespace: biological_process
def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
synonym: "neural groove formation" RELATED [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005062 ! results in formation of neural fold
relationship: BFO:0000050 GO:0014020 ! part of primary neural tube formation
relationship: RO:0002297 UBERON:0005062 ! results in formation of neural fold

[Term]
id: GO:0001873
name: polysaccharide immune receptor activity
namespace: molecular_function
def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091]
synonym: "polysaccharide receptor activity" BROAD []
is_a: GO:0038187 ! pattern recognition receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: BFO:0000051 GO:0030247 ! has part polysaccharide binding
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide

[Term]
id: GO:0001885
name: endothelial cell development
namespace: biological_process
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell
relationship: BFO:0000050 GO:0045446 ! part of endothelial cell differentiation
relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell

[Term]
id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell
relationship: BFO:0000050 GO:0001885 ! part of endothelial cell development
relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell

[Term]
id: GO:0001894
name: tissue homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]
synonym: "tissue maintenance" NARROW [GOC:add]
is_a: GO:0060249 ! anatomical structure homeostasis
relationship: BFO:0000050 GO:0048871 ! part of multicellular organismal-level homeostasis

[Term]
id: GO:0001932
name: regulation of protein phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0042325 ! regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006468 ! regulates protein phosphorylation
relationship: RO:0002211 GO:0006468 ! regulates protein phosphorylation

[Term]
id: GO:0001933
name: negative regulation of protein phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein amino acid phosphorylation" EXACT []
synonym: "down-regulation of protein amino acid phosphorylation" EXACT []
synonym: "downregulation of protein amino acid phosphorylation" EXACT []
synonym: "inhibition of protein amino acid phosphorylation" NARROW []
synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0042326 ! negative regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation
relationship: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylation

[Term]
id: GO:0001934
name: positive regulation of protein phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein amino acid phosphorylation" NARROW []
synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid phosphorylation" NARROW []
synonym: "up regulation of protein amino acid phosphorylation" EXACT []
synonym: "up-regulation of protein amino acid phosphorylation" EXACT []
synonym: "upregulation of protein amino acid phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation
relationship: RO:0002213 GO:0006468 ! positively regulates protein phosphorylation

[Term]
id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell
relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell

[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation
relationship: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation

[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation
relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell proliferation

[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation
relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell proliferation

[Term]
id: GO:0001941
name: postsynaptic membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]
synonym: "post-synaptic membrane organization" EXACT []
synonym: "postsynaptic membrane organisation" EXACT []
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane
relationship: BFO:0000050 GO:0099173 ! part of postsynapse organization
relationship: RO:0002592 GO:0045211 ! results in organization of postsynaptic membrane

[Term]
id: GO:0001944
name: vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature
relationship: BFO:0000050 GO:0072359 ! part of circulatory system development
relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature

[Term]
id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel
relationship: BFO:0000050 GO:0001568 ! part of blood vessel development
relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel

[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion
relationship: RO:0002213 GO:0007269 ! positively regulates neurotransmitter secretion

[Term]
id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "dermal ossification" NARROW [GO_REF:0000034]
synonym: "intramembranous bone ossification" RELATED [GOC:cjm]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0036072 ! direct ossification

[Term]
id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cytokine mediated signalling pathway" EXACT []
xref: Reactome:R-HSA-8939247 "RUNX1 regulates transcription of genes involved in interleukin signaling"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019221 ! regulates cytokine-mediated signaling pathway
relationship: RO:0002211 GO:0019221 ! regulates cytokine-mediated signaling pathway

[Term]
id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "down regulation of cytokine mediated signaling pathway" EXACT []
synonym: "down-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "downregulation of cytokine mediated signaling pathway" EXACT []
synonym: "inhibition of cytokine mediated signaling pathway" NARROW []
synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway
relationship: RO:0002212 GO:0019221 ! negatively regulates cytokine-mediated signaling pathway

[Term]
id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]
synonym: "activation of cytokine mediated signaling pathway" NARROW []
synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of cytokine mediated signalling pathway" EXACT []
synonym: "stimulation of cytokine mediated signaling pathway" NARROW []
synonym: "up regulation of cytokine mediated signaling pathway" EXACT []
synonym: "up-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "upregulation of cytokine mediated signaling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway
relationship: RO:0002213 GO:0019221 ! positively regulates cytokine-mediated signaling pathway

[Term]
id: GO:0001963
name: synaptic transmission, dopaminergic
namespace: biological_process
def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph]
synonym: "dopaminergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission
relationship: RO:0000057 CHEBI:59905 ! has participant
relationship: RO:0000057 CL:0000700 ! has participant dopaminergic neuron

[Term]
id: GO:0001976
name: nervous system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by neurological process" EXACT []
synonym: "fast control of arterial pressure" RELATED []
synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT []
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure
relationship: BFO:0000050 GO:0003073 ! part of regulation of systemic arterial blood pressure

[Term]
id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by hormone" EXACT []
synonym: "hormonal control of blood pressure" RELATED []
synonym: "hormonal regulation of blood pressure" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
is_a: GO:0050886 ! endocrine process

[Term]
id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by vasopressin" EXACT []
synonym: "vasopressin control of blood pressure" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
synonym: "epithelium morphogenesis" EXACT []
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium
relationship: BFO:0000050 GO:0060429 ! part of epithelium development
relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium

[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet
relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet

[Term]
id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002036
name: regulation of L-glutamate import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
synonym: "regulation of L-glutamate transport" BROAD []
synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098712 ! regulates L-glutamate import across plasma membrane
relationship: RO:0002211 GO:0098712 ! regulates L-glutamate import across plasma membrane
creation_date: 2012-06-13T07:34:08Z

[Term]
id: GO:0002037
name: negative regulation of L-glutamate import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down regulation of L-glutamate transport" BROAD []
synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "down-regulation of L-glutamate transport" BROAD []
synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "downregulation of L-glutamate transport" BROAD []
synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "inhibition of L-glutamate transport" NARROW []
synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "negative regulation of L-glutamate import" BROAD []
synonym: "negative regulation of L-glutamate transport" BROAD []
synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane
relationship: RO:0002212 GO:0098712 ! negatively regulates L-glutamate import across plasma membrane
creation_date: 2012-06-13T07:34:30Z

[Term]
id: GO:0002038
name: positive regulation of L-glutamate import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie]
synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie]
synonym: "activation of L-glutamate transport" NARROW []
synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie]
synonym: "positive regulation of L-glutamate import" BROAD []
synonym: "positive regulation of L-glutamate transport" BROAD []
synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "stimulation of L-glutamate transport" NARROW []
synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up regulation of L-glutamate transport" BROAD []
synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "up-regulation of L-glutamate transport" EXACT []
synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamate transport" BROAD []
synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane
relationship: RO:0002213 GO:0098712 ! positively regulates L-glutamate import across plasma membrane
creation_date: 2012-06-13T07:34:38Z

[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation
relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferation

[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation
relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell proliferation

[Term]
id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte
relationship: BFO:0000050 GO:0051216 ! part of cartilage development
relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte

[Term]
id: GO:0002063
name: chondrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte
relationship: BFO:0000050 GO:0002062 ! part of chondrocyte differentiation
relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte

[Term]
id: GO:0002064
name: epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell
relationship: BFO:0000050 GO:0030855 ! part of epithelial cell differentiation
relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell

[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell
relationship: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell

[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell
relationship: BFO:0000050 GO:0002065 ! part of columnar/cuboidal epithelial cell differentiation
relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell

[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell
relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glandular secretory epithelial cell

[Term]
id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell
relationship: BFO:0000050 GO:0002067 ! part of glandular epithelial cell differentiation
relationship: RO:0002296 CL:0000150 ! results in development of glandular secretory epithelial cell

[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell
relationship: BFO:0000050 GO:0002066 ! part of columnar/cuboidal epithelial cell development
relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell

[Term]
id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell
relationship: BFO:0000050 GO:0002064 ! part of epithelial cell development
relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell

[Term]
id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell
relationship: BFO:0000050 GO:0002068 ! part of glandular epithelial cell development
relationship: RO:0002299 CL:0000150 ! results in maturation of glandular secretory epithelial cell

[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup
relationship: BFO:0000050 GO:0060900 ! part of embryonic camera-type eye formation
relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup

[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation
relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell differentiation

[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by nervous system process
namespace: biological_process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT []
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system

[Term]
id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye
relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development
relationship: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye

[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye
relationship: BFO:0000050 GO:0002088 ! part of lens development in camera-type eye
relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis
relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye

[Term]
id: GO:0002158
name: osteoclast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]
is_a: GO:0070661 ! leukocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000092 ! acts on population of osteoclast
relationship: RO:0012003 CL:0000092 ! acts on population of osteoclast
creation_date: 2010-02-03T01:50:37Z

[Term]
id: GO:0002181
name: cytoplasmic translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]
comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms.
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0006412 ! translation
intersection_of: GO:0006412 ! translation
intersection_of: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome
relationship: RO:0002608 GO:0022626 ! process has causal agent cytosolic ribosome
creation_date: 2011-06-09T03:11:53Z

[Term]
id: GO:0002182
name: cytoplasmic translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd]
is_a: GO:0006414 ! translational elongation
intersection_of: GO:0006414 ! translational elongation
intersection_of: BFO:0000050 GO:0002181 ! part of cytoplasmic translation
relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation
creation_date: 2011-06-09T03:14:42Z

[Term]
id: GO:0002183
name: cytoplasmic translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]
is_a: GO:0006413 ! translational initiation
intersection_of: GO:0006413 ! translational initiation
intersection_of: BFO:0000050 GO:0002181 ! part of cytoplasmic translation
relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation
creation_date: 2011-06-09T03:15:48Z

[Term]
id: GO:0002184
name: cytoplasmic translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd]
is_a: GO:0006415 ! translational termination
intersection_of: GO:0006415 ! translational termination
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
relationship: BFO:0000050 GO:0002181 ! part of cytoplasmic translation
relationship: BFO:0000066 GO:0005829 ! occurs in cytosol
creation_date: 2011-06-09T03:17:13Z

[Term]
id: GO:0002213
name: defense response to insect
namespace: biological_process
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0006952 ! defense response
intersection_of: RO:0004009 NCBITaxon:50557 ! has primary input Insecta
relationship: RO:0004009 NCBITaxon:50557 ! has primary input Insecta

[Term]
id: GO:0002227
name: innate immune response in mucosa
namespace: biological_process
def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response
intersection_of: GO:0045087 ! innate immune response
intersection_of: BFO:0000066 UBERON:0000344 ! occurs in mucosa
relationship: BFO:0000066 UBERON:0000344 ! occurs in mucosa
relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata

[Term]
id: GO:0002232
name: leukocyte chemotaxis involved in inflammatory response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during inflammatory response" RELATED []
synonym: "leucocyte chemotaxis during inflammatory response" RELATED []
synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph]
is_a: GO:0002523 ! leukocyte migration involved in inflammatory response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response

[Term]
id: GO:0002233
name: leukocyte chemotaxis involved in immune response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during immune response" EXACT []
synonym: "leucocyte chemotaxis during immune response" EXACT []
is_a: GO:0002522 ! leukocyte migration involved in immune response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002244
name: hematopoietic progenitor cell differentiation
namespace: biological_process
def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell
relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis
relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell

[Term]
id: GO:0002250
name: adaptive immune response
namespace: biological_process
def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "acquired immune response" EXACT [ISBN:068340007X]
synonym: "immune memory response" EXACT [GOC:add]
xref: Reactome:R-HSA-1280218 "Adaptive Immune System"
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal]
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
namespace: biological_process
def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte
relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte

[Term]
id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000763 ! acts on population of myeloid cell
relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell

[Term]
id: GO:0002263
name: cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0001775 ! cell activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response
relationship: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002264
name: endothelial cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0042118 ! endothelial cell activation
intersection_of: GO:0042118 ! endothelial cell activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002265
name: astrocyte activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]
synonym: "astrocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0048143 ! astrocyte activation
intersection_of: GO:0048143 ! astrocyte activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002269
name: leukocyte activation involved in inflammatory response
namespace: biological_process
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during inflammatory response" RELATED []
synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response
relationship: BFO:0000050 GO:0006954 ! part of inflammatory response

[Term]
id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte
relationship: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte

[Term]
id: GO:0002275
name: myeloid cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002274 ! myeloid leukocyte activation
is_a: GO:0002366 ! leukocyte activation involved in immune response

[Term]
id: GO:0002277
name: myeloid dendritic cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002275 ! myeloid cell activation involved in immune response
intersection_of: GO:0001773 ! myeloid dendritic cell activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002280
name: monocyte activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245]
synonym: "monocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042117 ! monocyte activation
intersection_of: GO:0042117 ! monocyte activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002281
name: macrophage activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "macrophage activation during immune response" RELATED [GOC:tb]
synonym: "macrophage polarization involved in immune response" EXACT []
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0042116 ! macrophage activation
intersection_of: GO:0042116 ! macrophage activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response
relationship: BFO:0000050 GO:0002275 ! part of myeloid cell activation involved in immune response

[Term]
id: GO:0002282
name: microglial cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "microglial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001774 ! microglial cell activation
is_a: GO:0002281 ! macrophage activation involved in immune response
intersection_of: GO:0001774 ! microglial cell activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002284
name: myeloid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb]
is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response
is_a: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "lymphocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0046649 ! lymphocyte activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002286
name: T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell activation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte activation during immune response" RELATED []
synonym: "T-cell activation during immune response" RELATED []
synonym: "T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0042110 ! T cell activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002292
name: T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development involved in immune response" RELATED [GOC:add]
synonym: "T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte differentiation during immune response" RELATED []
synonym: "T-cell differentiation during immune response" RELATED []
synonym: "T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0030217 ! T cell differentiation
intersection_of: GO:0030217 ! T cell differentiation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002309
name: T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte proliferation during immune response" RELATED []
synonym: "T-cell proliferation during immune response" RELATED []
synonym: "T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0042098 ! T cell proliferation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell
relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell

[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell
relationship: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell

[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "serotonin production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during immune response" RELATED []
synonym: "leucocyte activation during immune response" RELATED []
synonym: "leukocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cytokine biosynthetic process involved in immune response" NARROW []
synonym: "cytokine production during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion involved in immune response" RELATED []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
intersection_of: GO:0001816 ! cytokine production
intersection_of: BFO:0000050 GO:0006955 ! part of immune response
relationship: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000451 ! process has causal agent dendritic cell
relationship: RO:0002608 CL:0000451 ! process has causal agent dendritic cell

[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002371 ! dendritic cell cytokine production
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0061082 ! myeloid leukocyte cytokine production
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell
relationship: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic cell

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase

[Term]
id: GO:0002385
name: mucosal immune response
namespace: biological_process
def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
synonym: "immune response in MALT" NARROW []
synonym: "immune response in mucosal-associated lymphoid tissue" NARROW []
synonym: "immune response in urogenital tract" NARROW []
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
is_a: GO:0065003 ! protein-containing complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex
relationship: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex

[Term]
id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex
relationship: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex

[Term]
id: GO:0002407
name: dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0036336 ! dendritic cell migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell

[Term]
id: GO:0002408
name: myeloid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0002407 ! dendritic cell chemotaxis
is_a: GO:0097529 ! myeloid leukocyte migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell
relationship: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic cell

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002376 ! immune system process
is_a: GO:0010467 ! gene expression

[Term]
id: GO:0002442
name: serotonin secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb]
synonym: "serotonin secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001820 ! serotonin secretion
intersection_of: GO:0001820 ! serotonin secretion
intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response
relationship: BFO:0000050 GO:0002351 ! part of serotonin production involved in inflammatory response

[Term]
id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte

[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte
relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000542 ! process has causal agent lymphocyte
relationship: RO:0002608 CL:0000542 ! process has causal agent lymphocyte

[Term]
id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0002376 ! immune system process
intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell
relationship: RO:0002608 CL:0000084 ! process has causal agent T cell

[Term]
id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: BFO:0000050 GO:0002456 ! part of T cell mediated immunity
relationship: BFO:0000066 CL:0000084 ! occurs in T cell

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell
relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell

[Term]
id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell
relationship: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell

[Term]
id: GO:0002471
name: monocyte antigen processing and presentation
namespace: biological_process
def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000576 ! occurs in monocyte
relationship: BFO:0000066 CL:0000576 ! occurs in monocyte

[Term]
id: GO:0002472
name: macrophage antigen processing and presentation
namespace: biological_process
def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage
relationship: BFO:0000066 CL:0000235 ! occurs in macrophage

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002520
name: immune system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002405 ! results in development of immune system
relationship: RO:0002296 UBERON:0002405 ! results in development of immune system

[Term]
id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte
relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis
relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte

[Term]
id: GO:0002522
name: leukocyte migration involved in immune response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: BFO:0000050 GO:0006955 ! part of immune response
relationship: BFO:0000050 GO:0006955 ! part of immune response

[Term]
id: GO:0002523
name: leukocyte migration involved in inflammatory response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" RELATED []
synonym: "immune cell trafficking during inflammatory response" RELATED []
synonym: "leucocyte migration during inflammatory response" RELATED []
synonym: "leucocyte trafficking during inflammatory response" RELATED []
synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph]
synonym: "leukocyte trafficking during inflammatory response" RELATED []
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response
relationship: BFO:0000050 GO:0006954 ! part of inflammatory response

[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "production of cellular mediator of acute inflammation" RELATED []
synonym: "production of molecular mediator involved in acute inflammatory response" BROAD []
is_a: GO:0032501 ! multicellular organismal process
relationship: BFO:0000050 GO:0006954 ! part of inflammatory response

[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
subset: gocheck_do_not_annotate
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
intersection_of: GO:0001816 ! cytokine production
intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response

[Term]
id: GO:0002548
name: monocyte chemotaxis
namespace: biological_process
def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000576 ! results in movement of monocyte
relationship: RO:0002565 CL:0000576 ! results in movement of monocyte

[Term]
id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]
synonym: "pro-T lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell
relationship: BFO:0000050 GO:0030217 ! part of T cell differentiation
relationship: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte
relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myeloid leukocyte

[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019882 ! regulates antigen processing and presentation
relationship: RO:0002211 GO:0019882 ! regulates antigen processing and presentation

[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation
relationship: RO:0002212 GO:0019882 ! negatively regulates antigen processing and presentation

[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation
relationship: RO:0002213 GO:0019882 ! positively regulates antigen processing and presentation

[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: RO:0002212 GO:0002504 ! negatively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: RO:0002213 GO:0002504 ! positively regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation
relationship: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation

[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation
relationship: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antigen processing and presentation

[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation
relationship: RO:0002213 GO:0002468 ! positively regulates dendritic cell antigen processing and presentation

[Term]
id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation
relationship: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation
relationship: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation
relationship: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002613
name: regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation
relationship: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation

[Term]
id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "down regulation of monocyte antigen processing and presentation" EXACT []
synonym: "down-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "downregulation of monocyte antigen processing and presentation" EXACT []
synonym: "inhibition of monocyte antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation
relationship: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen processing and presentation

[Term]
id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "activation of monocyte antigen processing and presentation" NARROW []
synonym: "stimulation of monocyte antigen processing and presentation" NARROW []
synonym: "up regulation of monocyte antigen processing and presentation" EXACT []
synonym: "up-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "upregulation of monocyte antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation
relationship: RO:0002213 GO:0002471 ! positively regulates monocyte antigen processing and presentation

[Term]
id: GO:0002616
name: regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation
relationship: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation

[Term]
id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "down regulation of macrophage antigen processing and presentation" EXACT []
synonym: "down-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "downregulation of macrophage antigen processing and presentation" EXACT []
synonym: "inhibition of macrophage antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation
relationship: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen processing and presentation

[Term]
id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "activation of macrophage antigen processing and presentation" NARROW []
synonym: "stimulation of macrophage antigen processing and presentation" NARROW []
synonym: "up regulation of macrophage antigen processing and presentation" EXACT []
synonym: "up-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "upregulation of macrophage antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation
relationship: RO:0002213 GO:0002472 ! positively regulates macrophage antigen processing and presentation

[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002457 ! regulates T cell antigen processing and presentation
relationship: RO:0002211 GO:0002457 ! regulates T cell antigen processing and presentation

[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation
relationship: RO:0002212 GO:0002457 ! negatively regulates T cell antigen processing and presentation

[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation
relationship: RO:0002213 GO:0002457 ! positively regulates T cell antigen processing and presentation

[Term]
id: GO:0002679
name: respiratory burst involved in defense response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499]
is_a: GO:0002252 ! immune effector process
is_a: GO:0045730 ! respiratory burst
intersection_of: GO:0045730 ! respiratory burst
intersection_of: BFO:0000050 GO:0006952 ! part of defense response
relationship: BFO:0000050 GO:0006952 ! part of defense response

[Term]
id: GO:0002682
name: regulation of immune system process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002376 ! regulates immune system process
relationship: RO:0002211 GO:0002376 ! regulates immune system process

[Term]
id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002376 ! negatively regulates immune system process
relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process

[Term]
id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002376 ! positively regulates immune system process
relationship: RO:0002213 GO:0002376 ! positively regulates immune system process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050900 ! regulates leukocyte migration
relationship: RO:0002211 GO:0050900 ! regulates leukocyte migration

[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration
relationship: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050900 ! positively regulates leukocyte migration
relationship: RO:0002213 GO:0050900 ! positively regulates leukocyte migration

[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "regulation of immune cell chemotaxis" EXACT []
synonym: "regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis
relationship: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis

[Term]
id: GO:0002689
name: negative regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "down regulation of leukocyte chemotaxis" EXACT []
synonym: "down-regulation of leukocyte chemotaxis" EXACT []
synonym: "downregulation of leukocyte chemotaxis" EXACT []
synonym: "inhibition of leukocyte chemotaxis" NARROW []
synonym: "negative regulation of immune cell chemotaxis" EXACT []
synonym: "negative regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050922 ! negative regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis
relationship: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis

[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "activation of leukocyte chemotaxis" NARROW []
synonym: "positive regulation of immune cell chemotaxis" EXACT []
synonym: "positive regulation of leucocyte chemotaxis" EXACT []
synonym: "stimulation of leukocyte chemotaxis" NARROW []
synonym: "up regulation of leukocyte chemotaxis" EXACT []
synonym: "up-regulation of leukocyte chemotaxis" EXACT []
synonym: "upregulation of leukocyte chemotaxis" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis
relationship: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis

[Term]
id: GO:0002694
name: regulation of leukocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045321 ! regulates leukocyte activation
relationship: RO:0002211 GO:0045321 ! regulates leukocyte activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation
relationship: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045321 ! positively regulates leukocyte activation
relationship: RO:0002213 GO:0045321 ! positively regulates leukocyte activation

[Term]
id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002252 ! regulates immune effector process
relationship: RO:0002211 GO:0002252 ! regulates immune effector process

[Term]
id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002252 ! negatively regulates immune effector process
relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002252 ! positively regulates immune effector process
relationship: RO:0002213 GO:0002252 ! positively regulates immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0010468 ! regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response
relationship: RO:0002211 GO:0002440 ! regulates production of molecular mediator of immune response

[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010629 ! negative regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response
relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecular mediator of immune response

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010628 ! positive regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response
relationship: RO:0002213 GO:0002440 ! positively regulates production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity
relationship: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity

[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity
relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated immunity

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity
relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity
relationship: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity

[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity
relationship: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity
relationship: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated immunity

[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002456 ! regulates T cell mediated immunity
relationship: RO:0002211 GO:0002456 ! regulates T cell mediated immunity

[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity
relationship: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immunity

[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity
relationship: RO:0002213 GO:0002456 ! positively regulates T cell mediated immunity

[Term]
id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response
relationship: RO:0002211 GO:0002367 ! regulates cytokine production involved in immune response

[Term]
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "negative regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response
relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production involved in immune response

[Term]
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "positive regulation of cytokine secretion involved in immune response" NARROW []
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
synonym: "upregulation of cytokine production during immune response" RELATED []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response
relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production involved in immune response

[Term]
id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002369 ! regulates T cell cytokine production
relationship: RO:0002211 GO:0002369 ! regulates T cell cytokine production

[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production
relationship: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine production

[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production
relationship: RO:0002213 GO:0002369 ! positively regulates T cell cytokine production

[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine production
relationship: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine production

[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production
relationship: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytokine production

[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production
relationship: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytokine production

[Term]
id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine production
relationship: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine production

[Term]
id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production
relationship: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cell cytokine production

[Term]
id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "activation of myeloid dendritic cell cytokine production" NARROW []
synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW []
synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production
relationship: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cell cytokine production

[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation
relationship: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiation

[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation
relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte differentiation

[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation
relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte differentiation

[Term]
id: GO:0002790
name: peptide secretion
namespace: biological_process
def: "The controlled release of a peptide from a cell or a tissue." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion

[Term]
id: GO:0002791
name: regulation of peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002790 ! regulates peptide secretion
relationship: RO:0002211 GO:0002790 ! regulates peptide secretion

[Term]
id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002790 ! negatively regulates peptide secretion
relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion

[Term]
id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002790 ! positively regulates peptide secretion
relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion

[Term]
id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002250 ! regulates adaptive immune response
relationship: RO:0002211 GO:0002250 ! regulates adaptive immune response

[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response
relationship: RO:0002212 GO:0002250 ! negatively regulates adaptive immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002250 ! positively regulates adaptive immune response
relationship: RO:0002213 GO:0002250 ! positively regulates adaptive immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata <vertebrates>
relationship: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: RO:0002212 GO:0002460 ! negatively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: RO:0002213 GO:0002460 ! positively regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009607 ! regulates response to biotic stimulus
relationship: RO:0002211 GO:0009607 ! regulates response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus
relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus
relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic stimulus

[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity
relationship: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity

[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity
relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte mediated immunity

[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity
relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte mediated immunity

[Term]
id: GO:0002932
name: tendon sheath development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath
relationship: BFO:0000050 GO:0035989 ! part of tendon development
relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheath
creation_date: 2012-04-23T02:11:22Z

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0003006
name: developmental process involved in reproduction
namespace: biological_process
def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
synonym: "puberty" NARROW [GOC:dph]
synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process
intersection_of: GO:0022414 ! reproductive process
intersection_of: GO:0032502 ! developmental process

[Term]
id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ

[Term]
id: GO:0003008
name: system process
namespace: biological_process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue
relationship: BFO:0000050 GO:0050881 ! part of musculoskeletal movement
relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue

[Term]
id: GO:0003012
name: muscle system process
namespace: biological_process
def: "An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
subset: goslim_drosophila
subset: goslim_generic
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003013
name: circulatory system process
namespace: biological_process
def: "An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
subset: goslim_chembl
subset: goslim_generic
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
namespace: biological_process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003016
name: respiratory system process
namespace: biological_process
def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
subset: goslim_generic
synonym: "respiratory gaseous exchange" EXACT []
is_a: GO:0003008 ! system process
relationship: BFO:0000050 GO:0007585 ! part of respiratory gaseous exchange by respiratory system

[Term]
id: GO:0003032
name: detection of oxygen
namespace: biological_process
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
namespace: biological_process
def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation mediated by a chemical signal" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003073
name: regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell
intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell
relationship: RO:0002231 CL:0000222 ! has start location mesodermal cell
relationship: RO:0002232 CL:0000223 ! has end location endodermal cell
creation_date: 2009-09-22T03:07:34Z

[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell
intersection_of: RO:0002232 CL:0000222 ! has end location mesodermal cell
relationship: RO:0002231 CL:0000223 ! has start location endodermal cell
relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell
creation_date: 2009-09-22T03:10:29Z

[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate
creation_date: 2009-09-22T04:12:18Z

[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0035050 ! part of embryonic heart tube development
relationship: BFO:0000050 GO:0048562 ! part of embryonic organ morphogenesis
relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube
creation_date: 2009-09-22T04:21:17Z

[Term]
id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004141 ! results in formation of heart tube
relationship: BFO:0000050 GO:0003143 ! part of embryonic heart tube morphogenesis
relationship: RO:0002297 UBERON:0004141 ! results in formation of heart tube
creation_date: 2009-09-22T04:22:34Z

[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation
creation_date: 2009-09-22T04:26:03Z

[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: BFO:0000050 GO:0060914 ! part of heart formation
relationship: BFO:0000050 GO:0061308 ! part of cardiac neural crest cell development involved in heart development
creation_date: 2009-09-22T04:29:55Z

[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum
relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum
creation_date: 2009-09-22T07:51:01Z

[Term]
id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part
relationship: BFO:0000050 GO:0060412 ! part of ventricular septum morphogenesis
relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part
creation_date: 2009-09-22T07:51:41Z

[Term]
id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part
relationship: BFO:0000050 GO:0060412 ! part of ventricular septum morphogenesis
relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part
creation_date: 2009-09-22T07:53:28Z

[Term]
id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract
creation_date: 2009-09-22T07:59:24Z

[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: BFO:0000050 GO:0003144 ! part of embryonic heart tube formation
relationship: BFO:0000050 GO:0003145 ! part of embryonic heart tube formation via epithelial folding
creation_date: 2009-09-23T10:10:24Z

[Term]
id: GO:0003156
name: regulation of animal organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048645 ! regulates animal organ formation
relationship: RO:0002211 GO:0048645 ! regulates animal organ formation
creation_date: 2009-09-30T11:21:09Z

[Term]
id: GO:0003157
name: endocardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium
creation_date: 2009-10-01T12:42:27Z

[Term]
id: GO:0003158
name: endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium
relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium
creation_date: 2009-10-01T12:50:57Z

[Term]
id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium
relationship: BFO:0000050 GO:0003158 ! part of endothelium development
relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium
creation_date: 2009-10-01T01:34:06Z

[Term]
id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium
relationship: BFO:0000050 GO:0003157 ! part of endocardium development
relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium
creation_date: 2009-10-01T01:37:26Z

[Term]
id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart
relationship: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart
creation_date: 2009-10-01T01:57:16Z

[Term]
id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node
relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development
relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node
creation_date: 2009-10-01T02:05:13Z

[Term]
id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0003228 ! atrial cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node
relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development
relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node
creation_date: 2009-10-01T02:06:09Z

[Term]
id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system
relationship: BFO:0000050 GO:0003161 ! part of cardiac conduction system development
relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system
creation_date: 2009-10-01T02:07:12Z

[Term]
id: GO:0003165
name: Purkinje myocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber development" EXACT []
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber
relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development
relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber
creation_date: 2009-10-01T02:07:50Z

[Term]
id: GO:0003168
name: Purkinje myocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber cell differentiation" EXACT []
is_a: GO:0060932 ! His-Purkinje system cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte
relationship: BFO:0000050 GO:0003165 ! part of Purkinje myocyte development
relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte
creation_date: 2009-10-01T02:49:54Z

[Term]
id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein
relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac vein
creation_date: 2009-10-08T10:45:41Z

[Term]
id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion
creation_date: 2009-10-08T01:17:43Z

[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003197 ! part of endocardial cushion development
relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion
creation_date: 2009-10-08T01:43:22Z

[Term]
id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton
creation_date: 2009-10-13T09:05:04Z

[Term]
id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber
creation_date: 2009-10-13T09:11:18Z

[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003205 ! part of cardiac chamber development
relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber
creation_date: 2009-10-13T09:14:51Z

[Term]
id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004151 ! results in formation of cardiac chamber
relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis
relationship: RO:0002297 UBERON:0004151 ! results in formation of cardiac chamber
creation_date: 2009-10-13T09:29:13Z

[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle
relationship: BFO:0000050 GO:0003231 ! part of cardiac ventricle development
relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle
creation_date: 2009-10-13T09:38:44Z

[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium
relationship: BFO:0000050 GO:0003230 ! part of cardiac atrium development
relationship: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium
creation_date: 2009-10-13T09:39:44Z

[Term]
id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium
relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis
relationship: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium
creation_date: 2009-10-13T09:44:25Z

[Term]
id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventricle
relationship: BFO:0000050 GO:0003208 ! part of cardiac ventricle morphogenesis
relationship: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventricle
creation_date: 2009-10-13T09:46:27Z

[Term]
id: GO:0003212
name: cardiac left atrium morphogenesis
namespace: biological_process
def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium
relationship: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium
creation_date: 2009-10-13T09:48:16Z

[Term]
id: GO:0003213
name: cardiac right atrium morphogenesis
namespace: biological_process
def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium
relationship: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium
creation_date: 2009-10-13T09:49:03Z

[Term]
id: GO:0003214
name: cardiac left ventricle morphogenesis
namespace: biological_process
def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle
relationship: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle
creation_date: 2009-10-13T09:50:08Z

[Term]
id: GO:0003215
name: cardiac right ventricle morphogenesis
namespace: biological_process
def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle
relationship: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle
creation_date: 2009-10-13T09:50:57Z

[Term]
id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002079 ! results in formation of left cardiac atrium
relationship: BFO:0000050 GO:0003212 ! part of cardiac left atrium morphogenesis
relationship: RO:0002297 UBERON:0002079 ! results in formation of left cardiac atrium
creation_date: 2009-10-13T09:52:31Z

[Term]
id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002078 ! results in formation of right cardiac atrium
relationship: BFO:0000050 GO:0003213 ! part of cardiac right atrium morphogenesis
relationship: RO:0002297 UBERON:0002078 ! results in formation of right cardiac atrium
creation_date: 2009-10-13T09:53:12Z

[Term]
id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002084 ! results in formation of heart left ventricle
relationship: BFO:0000050 GO:0003214 ! part of cardiac left ventricle morphogenesis
relationship: RO:0002297 UBERON:0002084 ! results in formation of heart left ventricle
creation_date: 2009-10-13T09:54:33Z

[Term]
id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002080 ! results in formation of heart right ventricle
relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis
relationship: RO:0002297 UBERON:0002080 ! results in formation of heart right ventricle
creation_date: 2009-10-13T09:55:38Z

[Term]
id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle
relationship: BFO:0000050 GO:0003214 ! part of cardiac left ventricle morphogenesis
relationship: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle
creation_date: 2009-10-13T10:18:05Z

[Term]
id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle
relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis
relationship: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle
creation_date: 2009-10-13T10:26:33Z

[Term]
id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "atrial myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium
relationship: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium
creation_date: 2009-10-13T10:53:18Z

[Term]
id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle
relationship: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle
creation_date: 2009-10-13T10:56:01Z

[Term]
id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium
relationship: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium
creation_date: 2009-10-13T11:02:07Z

[Term]
id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle
relationship: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle
creation_date: 2009-10-13T11:03:16Z

[Term]
id: GO:0003235
name: sinus venosus development
namespace: biological_process
def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002063 ! results in development of sinus venosus
relationship: RO:0002296 UBERON:0002063 ! results in development of sinus venosus
creation_date: 2009-10-13T11:12:34Z

[Term]
id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus
relationship: BFO:0000050 GO:0003235 ! part of sinus venosus development
relationship: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus
creation_date: 2009-10-13T11:16:52Z

[Term]
id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus
relationship: BFO:0000050 GO:0003236 ! part of sinus venosus morphogenesis
relationship: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus
creation_date: 2009-10-13T11:18:34Z

[Term]
id: GO:0003241
name: growth involved in heart morphogenesis
namespace: biological_process
def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
intersection_of: GO:0040007 ! growth
intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0060419 ! part of heart growth
creation_date: 2009-10-13T11:28:46Z

[Term]
id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0055017 ! cardiac muscle tissue growth
intersection_of: GO:0055017 ! cardiac muscle tissue growth
intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0055008 ! part of cardiac muscle tissue morphogenesis
creation_date: 2009-10-13T11:44:21Z

[Term]
id: GO:0003248
name: heart capillary growth
namespace: biological_process
def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary
relationship: BFO:0000050 GO:0060419 ! part of heart growth
relationship: BFO:0000050 GO:0060976 ! part of coronary vasculature development
relationship: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary
creation_date: 2009-10-13T11:53:12Z

[Term]
id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
relationship: BFO:0000050 GO:0061309 ! part of cardiac neural crest cell development involved in outflow tract morphogenesis
creation_date: 2009-10-13T02:14:16Z

[Term]
id: GO:0003260
name: cardioblast migration
namespace: biological_process
def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0002664 ! results in movement of cardioblast
relationship: RO:0002565 CL:0002664 ! results in movement of cardioblast
creation_date: 2009-10-15T01:52:25Z

[Term]
id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002062 ! results in formation of endocardial cushion
relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
relationship: RO:0002297 UBERON:0002062 ! results in formation of endocardial cushion
creation_date: 2009-10-20T08:53:19Z

[Term]
id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0003272 ! part of endocardial cushion formation
relationship: BFO:0000050 GO:0003272 ! part of endocardial cushion formation
creation_date: 2009-10-20T09:08:44Z

[Term]
id: GO:0003274
name: endocardial cushion fusion
namespace: biological_process
def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart]
is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
creation_date: 2009-10-20T09:26:32Z

[Term]
id: GO:0003275
name: apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in outflow tract morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
creation_date: 2009-10-20T09:30:01Z

[Term]
id: GO:0003277
name: apoptotic process involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
creation_date: 2009-10-20T09:37:03Z

[Term]
id: GO:0003278
name: apoptotic process involved in heart morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in heart morphogenesis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
creation_date: 2009-10-20T09:40:22Z

[Term]
id: GO:0003279
name: cardiac septum development
namespace: biological_process
def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
synonym: "heart septum development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002099 ! results in development of cardiac septum
relationship: BFO:0000050 GO:0003205 ! part of cardiac chamber development
relationship: RO:0002296 UBERON:0002099 ! results in development of cardiac septum
creation_date: 2009-10-20T09:45:13Z

[Term]
id: GO:0003281
name: ventricular septum development
namespace: biological_process
def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]
synonym: "interventricular septum development" EXACT [GOC:mtg_heart]
synonym: "septum inferius development" NARROW [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002094 ! results in development of interventricular septum
relationship: BFO:0000050 GO:0003231 ! part of cardiac ventricle development
relationship: RO:0002296 UBERON:0002094 ! results in development of interventricular septum
creation_date: 2009-10-20T10:04:51Z

[Term]
id: GO:0003283
name: atrial septum development
namespace: biological_process
def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002085 ! results in development of interatrial septum
relationship: BFO:0000050 GO:0003230 ! part of cardiac atrium development
relationship: RO:0002296 UBERON:0002085 ! results in development of interatrial septum
creation_date: 2009-10-20T10:10:38Z

[Term]
id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell
relationship: BFO:0000050 GO:0003279 ! part of cardiac septum development
relationship: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell
creation_date: 2009-10-20T11:03:46Z

[Term]
id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]
is_a: GO:0014896 ! muscle hypertrophy
creation_date: 2009-10-22T09:24:51Z

[Term]
id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]
is_a: GO:0014897 ! striated muscle hypertrophy
creation_date: 2009-10-22T10:33:56Z

[Term]
id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
is_a: GO:0003298 ! physiological muscle hypertrophy
is_a: GO:0003300 ! cardiac muscle hypertrophy
relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth
creation_date: 2009-10-22T10:38:10Z

[Term]
id: GO:0003313
name: heart rudiment development
namespace: biological_process
def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]
synonym: "heart cone development" EXACT [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004291 ! results in development of heart rudiment
relationship: BFO:0000050 GO:0035050 ! part of embryonic heart tube development
relationship: RO:0002296 UBERON:0004291 ! results in development of heart rudiment
creation_date: 2009-10-27T08:32:40Z

[Term]
id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]
synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003313 ! part of heart rudiment development
relationship: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudiment
creation_date: 2009-10-27T08:38:04Z

[Term]
id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]
synonym: "heart cone formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment
relationship: BFO:0000050 GO:0003314 ! part of heart rudiment morphogenesis
relationship: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment
creation_date: 2009-10-27T08:43:37Z

[Term]
id: GO:0003330
name: regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion
relationship: RO:0002211 GO:0070278 ! regulates extracellular matrix constituent secretion
creation_date: 2009-11-02T02:07:40Z

[Term]
id: GO:0003331
name: positive regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion
relationship: RO:0002213 GO:0070278 ! positively regulates extracellular matrix constituent secretion
creation_date: 2009-11-02T02:11:22Z

[Term]
id: GO:0003332
name: negative regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion
relationship: RO:0002212 GO:0070278 ! negatively regulates extracellular matrix constituent secretion
creation_date: 2009-11-02T02:13:49Z

[Term]
id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "amino acid membrane transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
creation_date: 2009-11-02T02:36:11Z

[Term]
id: GO:0003341
name: cilium movement
namespace: biological_process
def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliary motility" RELATED []
synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "flagellar motility" RELATED []
synonym: "flagellar movement" NARROW [GOC:bf]
synonym: "flagellum movement" NARROW []
synonym: "microtubule-based flagellum movement" EXACT []
is_a: GO:0007018 ! microtubule-based movement
intersection_of: GO:0007018 ! microtubule-based movement
intersection_of: RO:0002565 GO:0005929 ! results in movement of cilium
intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
relationship: RO:0002565 GO:0005929 ! results in movement of cilium
creation_date: 2009-11-24T09:56:26Z

[Term]
id: GO:0003342
name: proepicardium development
namespace: biological_process
def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004160 ! results in development of proepicardium
relationship: BFO:0000050 GO:0003343 ! part of septum transversum development
relationship: RO:0002296 UBERON:0004160 ! results in development of proepicardium
creation_date: 2009-12-01T10:30:17Z

[Term]
id: GO:0003343
name: septum transversum development
namespace: biological_process
def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004161 ! results in development of septum transversum
relationship: RO:0002296 UBERON:0004161 ! results in development of septum transversum
creation_date: 2009-12-01T10:40:17Z

[Term]
id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium
relationship: BFO:0000050 GO:0060039 ! part of pericardium development
relationship: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardium
creation_date: 2009-12-01T10:46:34Z

[Term]
id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0045446 ! endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell
relationship: RO:0002315 CL:0010008 ! results in acquisition of features of cardiac endothelial cell
creation_date: 2009-12-01T11:12:05Z

[Term]
id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "regulation of flagellum movement" RELATED []
synonym: "regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003341 ! regulates cilium movement
relationship: RO:0002211 GO:0003341 ! regulates cilium movement
creation_date: 2009-12-03T10:12:00Z

[Term]
id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "positive regulation of flagellum movement" RELATED []
synonym: "positive regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003341 ! positively regulates cilium movement
relationship: RO:0002213 GO:0003341 ! positively regulates cilium movement
creation_date: 2009-12-03T10:16:10Z

[Term]
id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "negative regulation of flagellum movement" RELATED []
synonym: "negative regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003341 ! negatively regulates cilium movement
relationship: RO:0002212 GO:0003341 ! negatively regulates cilium movement
creation_date: 2009-12-03T10:17:47Z

[Term]
id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]
synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron
relationship: RO:0002315 CL:0008025 ! results in acquisition of features of noradrenergic neuron
creation_date: 2009-12-03T10:34:30Z

[Term]
id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron
relationship: BFO:0000050 GO:0003357 ! part of noradrenergic neuron differentiation
relationship: RO:0002296 CL:0008025 ! results in development of noradrenergic neuron
creation_date: 2009-12-03T10:38:37Z

[Term]
id: GO:0003360
name: brainstem development
namespace: biological_process
def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002298 ! results in development of brainstem
relationship: RO:0002296 UBERON:0002298 ! results in development of brainstem
creation_date: 2009-12-03T10:47:20Z

[Term]
id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: BFO:0000050 GO:0003360 ! part of brainstem development
relationship: BFO:0000050 GO:0003360 ! part of brainstem development
creation_date: 2009-12-03T10:53:30Z

[Term]
id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration
relationship: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration
creation_date: 2009-12-08T04:50:41Z

[Term]
id: GO:0003367
name: cell-cell adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration
relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration
relationship: RO:0000053 PATO:0002487 ! bearer of single organismal process quality
creation_date: 2009-12-08T05:15:49Z

[Term]
id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration
relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity involved in ameboidal cell migration
creation_date: 2009-12-08T05:42:46Z

[Term]
id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation
relationship: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation
creation_date: 2009-12-09T06:54:44Z

[Term]
id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation
relationship: BFO:0000050 GO:0003379 ! part of establishment of cell polarity involved in gastrulation cell migration
creation_date: 2009-12-09T07:10:57Z

[Term]
id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0003382 ! epithelial cell morphogenesis
intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation
relationship: BFO:0000050 GO:0007369 ! part of gastrulation
creation_date: 2009-12-09T07:18:53Z

[Term]
id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell
relationship: BFO:0000050 GO:0002064 ! part of epithelial cell development
relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell
creation_date: 2009-12-09T07:21:06Z

[Term]
id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle
relationship: BFO:0000050 GO:0003404 ! part of optic vesicle morphogenesis
relationship: BFO:0000050 GO:0060900 ! part of embryonic camera-type eye formation
relationship: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle
creation_date: 2009-12-21T01:42:37Z

[Term]
id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle
relationship: BFO:0000050 GO:0048596 ! part of embryonic camera-type eye morphogenesis
relationship: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesicle
creation_date: 2009-12-21T01:54:34Z

[Term]
id: GO:0003407
name: neural retina development
namespace: biological_process
def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer
relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye
relationship: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer
creation_date: 2009-12-21T02:15:14Z

[Term]
id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis
relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis
creation_date: 2009-12-21T03:04:27Z

[Term]
id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002062 ! chondrocyte differentiation
intersection_of: GO:0002062 ! chondrocyte differentiation
intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis
relationship: BFO:0000050 GO:0060351 ! part of cartilage development involved in endochondral bone morphogenesis
creation_date: 2009-12-22T08:39:58Z

[Term]
id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090171 ! chondrocyte morphogenesis
intersection_of: GO:0090171 ! chondrocyte morphogenesis
intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis
relationship: BFO:0000050 GO:0003433 ! part of chondrocyte development involved in endochondral bone morphogenesis
creation_date: 2009-12-22T08:42:55Z

[Term]
id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098868 ! bone growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone
relationship: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone
creation_date: 2009-12-22T08:52:55Z

[Term]
id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002063 ! chondrocyte development
intersection_of: GO:0002063 ! chondrocyte development
intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis
relationship: BFO:0000050 GO:0003413 ! part of chondrocyte differentiation involved in endochondral bone morphogenesis
creation_date: 2009-12-22T12:42:44Z

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "molecular function" EXACT []
is_a: BFO:0000015 ! process
disjoint_from: GO:0005575 ! cellular_component
disjoint_from: GO:0008150 ! biological_process

[Term]
id: GO:0003676
name: nucleic acid binding
namespace: molecular_function
alt_id: GO:0000496
def: "Binding to a nucleic acid." [GOC:jl]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
synonym: "base pairing" NARROW []
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
alt_id: GO:0043566
def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
synonym: "structure specific DNA binding" RELATED []
synonym: "structure-specific DNA binding" RELATED []
is_a: GO:0003676 ! nucleic acid binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:16991 ! has primary input
relationship: RO:0004009 CHEBI:16991 ! has primary input

[Term]
id: GO:0003682
name: chromatin binding
namespace: molecular_function
def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "lamin/chromatin binding" NARROW []
synonym: "microtubule/chromatin interaction" NARROW []
synonym: "nuclear membrane vesicle binding to chromatin" NARROW []
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0000785 ! has primary input chromatin
relationship: RO:0004009 GO:0000785 ! has primary input chromatin

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
alt_id: GO:0000498
alt_id: GO:0044822
def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "base pairing with RNA" NARROW []
synonym: "poly(A) RNA binding" RELATED []
synonym: "poly(A)-RNA binding" RELATED []
synonym: "poly-A RNA binding" RELATED []
xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA"
is_a: GO:0003676 ! nucleic acid binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Enzyme
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0004518
name: nuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of ester linkages within nucleic acids." [ISBN:0198547684]
comment: Most nucleases are classed as hydrolases, though a minority are classed as lyases.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_plant
subset: goslim_yeast
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid

[Term]
id: GO:0004536
name: DNA nuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
synonym: "caspase-activated deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activity" EXACT []
xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40"
xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2"
xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)"
is_a: GO:0004518 ! nuclease activity
is_a: GO:0140097 ! catalytic activity, acting on DNA
relationship: BFO:0000050 GO:0006259 ! part of DNA metabolic process

[Term]
id: GO:0004553
name: hydrolase activity, hydrolyzing O-glycosyl compounds
namespace: molecular_function
alt_id: GO:0016800
def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
synonym: "O-glucosyl hydrolase activity" EXACT []
xref: EC:3.2.1.-
xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG"
xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP"
xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL"
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0004568
name: chitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [GOC:bf, GOC:kah, GOC:pde, PMID:11468293]
xref: Reactome:R-HSA-6786421 "CHIA hydrolyses chitin"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004888
name: transmembrane signaling receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling]
synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex"
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0004896
name: cytokine receptor activity
namespace: molecular_function
def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED []
synonym: "IL receptor" NARROW []
synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0140375 ! immune receptor activity
relationship: BFO:0000050 GO:0019221 ! part of cytokine-mediated signaling pathway
relationship: BFO:0000051 GO:0019955 ! has part cytokine binding

[Term]
id: GO:0004925
name: prolactin receptor activity
namespace: molecular_function
def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
is_a: GO:0004896 ! cytokine receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 PR:000013246 ! has primary input prolactin
relationship: BFO:0000050 GO:0038161 ! part of prolactin signaling pathway
relationship: RO:0004009 PR:000013246 ! has primary input prolactin

[Term]
id: GO:0004930
name: G protein-coupled receptor activity
namespace: molecular_function
def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, Wikipedia:GPCR]
subset: goslim_chembl
synonym: "EBV-induced receptor" NARROW []
synonym: "Epstein-Barr Virus-induced receptor activity" NARROW []
synonym: "G protein coupled receptor activity" EXACT []
synonym: "G protein linked receptor activity" EXACT []
synonym: "G-protein coupled receptor activity" EXACT []
synonym: "G-protein coupled receptor activity, unknown ligand" NARROW []
synonym: "G-protein linked receptor activity" EXACT []
synonym: "GPCR activity" EXACT []
synonym: "ligand-dependent GPCR activity" EXACT []
synonym: "Mas proto-oncogene receptor activity" NARROW []
synonym: "orphan G protein coupled receptor activity" NARROW []
synonym: "orphan G-protein coupled receptor activity" NARROW []
synonym: "orphan GPCR activity" NARROW []
synonym: "RDC1 receptor activity" NARROW []
synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "SREB receptor" NARROW []
synonym: "super conserved receptor expressed in brain receptor activity" NARROW []
xref: Reactome:R-HSA-114552 "Thrombin-activated PARs activate G12/13"
xref: Reactome:R-HSA-114558 "Thrombin-activated PARs activate Gq"
xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein"
xref: Reactome:R-HSA-381706 "GLP1R:GLP1 activates G(s)"
xref: Wikipedia:GPCR
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: BFO:0000050 GO:0007186 ! part of G protein-coupled receptor signaling pathway

[Term]
id: GO:0004977
name: melanocortin receptor activity
namespace: molecular_function
def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity

[Term]
id: GO:0004978
name: corticotropin receptor activity
namespace: molecular_function
def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai]
synonym: "ACTH receptor activity" EXACT []
synonym: "adrenocorticotropic hormone receptor activity" EXACT []
synonym: "adrenocorticotropin receptor activity" EXACT []
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:3892 ! has primary input
relationship: BFO:0000051 GO:0042562 ! has part hormone binding
relationship: RO:0004009 CHEBI:3892 ! has primary input

[Term]
id: GO:0004993
name: G protein-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]
synonym: "5-HT receptor" EXACT []
synonym: "5-hydroxytryptamine receptor" EXACT []
synonym: "G protein coupled serotonin receptor activity" EXACT []
synonym: "G-protein coupled serotonin receptor activity" EXACT []
xref: Wikipedia:5-HT_receptor
is_a: GO:0008227 ! G protein-coupled amine receptor activity
intersection_of: GO:0008227 ! G protein-coupled amine receptor activity
intersection_of: RO:0004009 CHEBI:350546 ! has primary input
relationship: BFO:0000050 GO:0098664 ! part of G protein-coupled serotonin receptor signaling pathway
relationship: BFO:0000051 GO:0051378 ! has part serotonin binding
relationship: RO:0004009 CHEBI:350546 ! has primary input

[Term]
id: GO:0005000
name: vasopressin receptor activity
namespace: molecular_function
def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW []
is_a: GO:0008528 ! G protein-coupled peptide receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:9937 ! has primary input
relationship: RO:0004009 CHEBI:9937 ! has primary input

[Term]
id: GO:0005102
name: signaling receptor binding
namespace: molecular_function
def: "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]
comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_plant
synonym: "receptor binding" BROAD []
synonym: "receptor ligand" NARROW []
synonym: "receptor-associated protein activity" RELATED []
xref: Wikipedia:Ligand_(biochemistry)
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005126
name: cytokine receptor binding
namespace: molecular_function
def: "Binding to a cytokine receptor." [GOC:mah, GOC:vw]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW []
is_a: GO:0005102 ! signaling receptor binding

[Term]
id: GO:0005172
name: vascular endothelial growth factor receptor binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor receptor." [GOC:ai]
synonym: "vascular endothelial growth factor" NARROW []
synonym: "vascular endothelial growth factor receptor ligand" NARROW []
synonym: "VEGF receptor binding" EXACT []
synonym: "VEGFR binding" EXACT []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000001971 ! has primary input vascular endothelial growth factor receptor
relationship: RO:0004009 PR:000001971 ! has primary input vascular endothelial growth factor receptor

[Term]
id: GO:0005173
name: stem cell factor receptor binding
namespace: molecular_function
def: "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217]
synonym: "KIT binding" NARROW []
synonym: "SCF" NARROW []
synonym: "SCFR binding" EXACT []
synonym: "stem cell factor" NARROW []
synonym: "stem cell factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000002065 ! has primary input mast/stem cell growth factor receptor
relationship: RO:0004009 PR:000002065 ! has primary input mast/stem cell growth factor receptor

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf]
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "carrier" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005275
name: amine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "amine/amide/polyamine channel activity" BROAD []
synonym: "amine/polyamine transmembrane transporter activity" EXACT []
synonym: "amino acid-polyamine transmembrane transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: BFO:0000050 GO:0015837 ! part of amine transport
relationship: RO:0004009 CHEBI:32952 ! has primary input amine

[Term]
id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles"
is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:1901375 ! acetate ester transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: RO:0004009 CHEBI:15355 ! has primary input

[Term]
id: GO:0005313
name: L-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "glutamate transmembrane transporter activity" BROAD []
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-glutamate transporter activity" BROAD []
xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle"
xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+"
xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+"
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
relationship: BFO:0000050 GO:0015813 ! part of L-glutamate transmembrane transport
relationship: RO:0004009 CHEBI:29985 ! has primary input

[Term]
id: GO:0005319
name: lipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
synonym: "apolipoprotein" RELATED []
synonym: "lipophorin" NARROW []
xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux"
xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx"
xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:R-HSA-5334794 "FABPs bind LCFAs"
xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region"
xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region"
xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane"
xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL"
xref: Reactome:R-HSA-8873834 "STARD10 transports PC from ER membrane to lamellar body membrane"
is_a: GO:0005215 ! transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: BFO:0000050 GO:0006869 ! part of lipid transport
relationship: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0005326
name: neurotransmitter transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
synonym: "neurotransmitter transporter activity" RELATED []
xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline"
xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft"
is_a: GO:0022857 ! transmembrane transporter activity
relationship: BFO:0000050 GO:0006836 ! part of neurotransmitter transport
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa

[Term]
id: GO:0005488
name: binding
namespace: molecular_function
def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]
subset: goslim_pir
subset: goslim_plant
synonym: "ligand" NARROW []
xref: Wikipedia:Binding_(molecular)
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005496
name: steroid binding
namespace: molecular_function
def: "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0008289 ! lipid binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:35341 ! has primary input steroid
relationship: RO:0004009 CHEBI:35341 ! has primary input steroid

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0001948
alt_id: GO:0045308
def: "Binding to a protein." [GOC:go_curators]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "glycoprotein binding" NARROW []
synonym: "protein amino acid binding" EXACT []
xref: Reactome:R-HSA-9866132 "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH"
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0005518
name: collagen binding
namespace: molecular_function
def: "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]
is_a: GO:0044877 ! protein-containing complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer
relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer

[Term]
id: GO:0005539
name: glycosaminoglycan binding
namespace: molecular_function
def: "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
is_a: GO:0097367 ! carbohydrate derivative binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:18085 ! has primary input
relationship: RO:0004009 CHEBI:18085 ! has primary input

[Term]
id: GO:0005540
name: hyaluronic acid binding
namespace: molecular_function
def: "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl]
synonym: "hyaluronan binding" EXACT []
is_a: GO:0005539 ! glycosaminoglycan binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:16336 ! has primary input
relationship: RO:0004009 CHEBI:16336 ! has primary input

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell or subcellular entity" EXACT []
synonym: "cellular component" EXACT []
synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315]
xref: NIF_Subcellular:sao1337158144
is_a: BFO:0000040 ! material entity
disjoint_from: GO:0008150 ! biological_process

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]
synonym: "fibrinogen" EXACT []
synonym: "fibrinogen alpha chain" NARROW []
synonym: "fibrinogen beta chain" NARROW []
synonym: "fibrinogen gamma chain" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: BFO:0000050 GO:0005615 ! part of extracellular space

[Term]
id: GO:0005581
name: collagen trimer
namespace: cellular_component
def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen
is_a: GO:0032991 ! protein-containing complex
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0005583
name: fibrillar collagen trimer
namespace: cellular_component
def: "Any triple helical collagen trimer that forms fibrils." [PMID:21421911]
is_a: GO:0005581 ! collagen trimer
intersection_of: GO:0005581 ! collagen trimer
intersection_of: BFO:0000050 GO:0098643 ! part of fibrillar collagen
disjoint_from: GO:0030936 ! transmembrane collagen trimer
relationship: BFO:0000050 GO:0098643 ! part of fibrillar collagen

[Term]
id: GO:0005585
name: collagen type II trimer
namespace: cellular_component
def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [PMID:21421911]
xref: Wikipedia:Collagen_type_II
is_a: GO:0005583 ! fibrillar collagen trimer

[Term]
id: GO:0005587
name: collagen type IV trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen_type_IV
is_a: GO:0098642 ! network-forming collagen trimer
relationship: BFO:0000050 GO:0140154 ! part of chicken-wire-like collagen network

[Term]
id: GO:0005604
name: basement membrane
namespace: cellular_component
def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [PMID:22505934, PMID:33605520, PMID:39223427]
comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.
synonym: "basal lamina" RELATED []
synonym: "basement lamina" RELATED []
synonym: "lamina densa" RELATED []
xref: Wikipedia:Basement_membrane
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0005614
name: interstitial matrix
namespace: cellular_component
def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:33605520, PMID:39223427, PMID:8450001]
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0005615
name: extracellular space
namespace: cellular_component
def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
synonym: "intercellular space" RELATED []
xref: NIF_Subcellular:sao1425028079
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005576 ! part of extracellular region

[Term]
id: GO:0005622
name: intracellular anatomical structure
namespace: cellular_component
def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
synonym: "internal to cell" EXACT []
synonym: "intracellular" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757]
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
disjoint_from: GO:0005737 ! cytoplasm
disjoint_from: GO:0005829 ! cytosol
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0005635
name: nuclear envelope
namespace: cellular_component
alt_id: GO:0005636
def: "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport." [ISBN:0198547684, PMID:16164970]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: Wikipedia:Nuclear_envelope
is_a: GO:0031967 ! organelle envelope
relationship: BFO:0000050 GO:0005634 ! part of nucleus
relationship: BFO:0000050 GO:0012505 ! part of endomembrane system

[Term]
id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]
synonym: "nucleus outer envelope" EXACT []
synonym: "perinuclear membrane" EXACT []
xref: NIF_Subcellular:sao1617136075
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0031968 ! organelle outer membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005634 ! bounding layer of nucleus
relationship: BFO:0000050 GO:0042175 ! part of nuclear outer membrane-endoplasmic reticulum membrane network
relationship: RO:0002007 GO:0005634 ! bounding layer of nucleus

[Term]
id: GO:0005677
name: chromatin silencing complex
namespace: cellular_component
def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah]
is_a: GO:0140513 ! nuclear protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002216 GO:0031507 ! capable of part of heterochromatin formation
relationship: RO:0002216 GO:0031507 ! capable of part of heterochromatin formation

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
xref: Wikipedia:Cytoplasm
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: NIF_Subcellular:sao1860313010
xref: Wikipedia:Mitochondrion
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0031967 ! organelle envelope
relationship: BFO:0000050 GO:0005739 ! part of mitochondrion

[Term]
id: GO:0005741
name: mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
synonym: "mitochondrion outer membrane" EXACT []
synonym: "outer mitochondrial membrane" EXACT []
synonym: "outer mitochondrion membrane" EXACT []
xref: NIF_Subcellular:sao1289741256
xref: Wikipedia:Outer_mitochondrial_membrane
is_a: GO:0031966 ! mitochondrial membrane
is_a: GO:0031968 ! organelle outer membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005739 ! bounding layer of mitochondrion
relationship: RO:0002007 GO:0005739 ! bounding layer of mitochondrion

[Term]
id: GO:0005759
name: mitochondrial matrix
namespace: cellular_component
def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]
synonym: "mitochondrial lumen" EXACT []
synonym: "mitochondrial stroma" NARROW []
xref: NIF_Subcellular:sao1804523077
xref: Wikipedia:Mitochondrial_matrix
is_a: GO:0070013 ! intracellular organelle lumen
relationship: BFO:0000050 GO:0005739 ! part of mitochondrion

[Term]
id: GO:0005761
name: mitochondrial ribosome
namespace: cellular_component
def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]
synonym: "55S ribosome, mitochondrial" NARROW []
is_a: GO:0000313 ! organellar ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: BFO:0000050 GO:0005759 ! part of mitochondrial matrix
relationship: BFO:0000050 GO:0005759 ! part of mitochondrial matrix

[Term]
id: GO:0005764
name: lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao585356902
xref: Wikipedia:Lysosome
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0005765
name: lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
synonym: "lysosome membrane" EXACT []
is_a: GO:0098852 ! lytic vacuole membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005764 ! bounding layer of lysosome
relationship: RO:0002007 GO:0005764 ! bounding layer of lysosome

[Term]
id: GO:0005766
name: primary lysosome
namespace: cellular_component
def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194]
xref: NIF_Subcellular:sao1140587416
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005773 ! bounding layer of vacuole
relationship: RO:0002007 GO:0005773 ! bounding layer of vacuole

[Term]
id: GO:0005775
name: vacuolar lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732]
is_a: GO:0070013 ! intracellular organelle lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: BFO:0000050 GO:0005773 ! part of vacuole
relationship: BFO:0000050 GO:0005773 ! part of vacuole

[Term]
id: GO:0005776
name: autophagosome
namespace: cellular_component
def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]
synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959]
synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959]
xref: NIF_Subcellular:sao8663416959
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732, PMID:9695800]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm
relationship: BFO:0000050 GO:0012505 ! part of endomembrane system
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0005798
name: Golgi-associated vesicle
namespace: cellular_component
def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
synonym: "Golgi vesicle" RELATED []
synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748]
xref: NIF_Subcellular:sao819927218
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0005811
name: lipid droplet
namespace: cellular_component
def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.
subset: goslim_chembl
subset: goslim_generic
synonym: "adiposome" EXACT []
synonym: "lipid body" EXACT []
synonym: "lipid particle" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005829
name: cytosol
namespace: cellular_component
def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
xref: NIF_Subcellular:sao101633890
xref: Wikipedia:Cytosol
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046]
synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653]
synonym: "ribosomal RNA" RELATED []
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
is_a: GO:0043232 ! intracellular membraneless organelle
relationship: BFO:0000051 CHEBI:33697 ! has part ribonucleic acid
relationship: BFO:0000051 PR:000000001 ! has part protein
relationship: RO:0002216 GO:0006412 ! capable of part of translation

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_yeast
xref: Wikipedia:Cytoskeleton
is_a: GO:0043232 ! intracellular membraneless organelle

[Term]
id: GO:0005874
name: microtubule
namespace: cellular_component
def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
subset: goslim_metagenomics
synonym: "microtubuli" EXACT []
synonym: "microtubulus" EXACT []
synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196]
xref: NIF_Subcellular:sao1846835077
xref: Wikipedia:Microtubule
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton

[Term]
id: GO:0005879
name: axonemal microtubule
namespace: cellular_component
def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194]
is_a: GO:0005881 ! cytoplasmic microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: BFO:0000050 GO:0005930 ! part of axoneme
relationship: BFO:0000050 GO:0005930 ! part of axoneme

[Term]
id: GO:0005880
name: nuclear microtubule
namespace: cellular_component
def: "Any microtubule in the nucleus of a cell." [GOC:mah]
is_a: GO:0005874 ! microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: BFO:0000050 GO:0005634 ! part of nucleus
relationship: BFO:0000050 GO:0005634 ! part of nucleus

[Term]
id: GO:0005881
name: cytoplasmic microtubule
namespace: cellular_component
def: "Any microtubule in the cytoplasm of a cell." [GOC:mah]
synonym: "non-spindle-associated astral microtubule" NARROW []
is_a: GO:0005874 ! microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0005884
name: actin filament
namespace: cellular_component
def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
synonym: "microfilament" EXACT []
xref: FMA:63850
xref: NIF_Subcellular:sao1588493326
xref: Wikipedia:Actin
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005887
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645]
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "integral component of plasma membrane" NARROW []
synonym: "integral to plasma membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: NIF_Subcellular:sao1663586795
xref: Wikipedia:Cell_membrane
is_a: GO:0016020 ! membrane
relationship: BFO:0000050 GO:0071944 ! part of cell periphery

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]
comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
subset: goslim_pir
synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673]
xref: NIF_Subcellular:sao671419673
xref: Wikipedia:Microvillus
is_a: GO:0098858 ! actin-based cell projection
relationship: BFO:0000050 CL:0000066 ! part of epithelial cell
relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle

[Term]
id: GO:0005903
name: brush border
namespace: cellular_component
def: "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Brush_border
is_a: GO:0098862 ! cluster of actin-based cell projections
relationship: BFO:0000050 CL:0000066 ! part of epithelial cell
relationship: BFO:0000050 GO:0045177 ! part of apical part of cell
relationship: BFO:0000051 GO:0005902 ! has part microvillus

[Term]
id: GO:0005911
name: cell-cell junction
namespace: cellular_component
def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
synonym: "cell-cell contact region" BROAD []
synonym: "cell-cell contact zone" BROAD []
synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368]
xref: NIF_Subcellular:sao1922892319
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0005923
name: bicellular tight junction
namespace: cellular_component
def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
synonym: "zonula occludens" EXACT []
xref: NIF_Subcellular:sao1939999134
xref: Wikipedia:Tight_junction
is_a: GO:0070160 ! tight junction
relationship: BFO:0000050 GO:0043296 ! part of apical junction complex

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
synonym: "eukaryotic flagellum" EXACT []
synonym: "flagellum" RELATED []
synonym: "microtubule-based flagellum" EXACT []
synonym: "primary cilium" NARROW []
xref: FMA:67181
xref: NIF_Subcellular:sao787716553
xref: Wikipedia:Cilium
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: BFO:0000051 GO:0030990 ! has part intraciliary transport particle
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0005930
name: axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
subset: goslim_pir
synonym: "ciliary axoneme" EXACT []
synonym: "cilium axoneme" EXACT []
synonym: "flagellar axoneme" EXACT []
synonym: "flagellum axoneme" EXACT []
xref: Wikipedia:Axoneme
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton
relationship: BFO:0000050 GO:0097014 ! part of ciliary plasm
relationship: BFO:0000051 GO:0005874 ! has part microtubule

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "ectoplasm" NARROW []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0071944 ! part of cell periphery
relationship: BFO:0000050 GO:0071944 ! part of cell periphery

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "carbohydrate metabolism" EXACT []
xref: Reactome:R-HSA-71387 "Metabolism of carbohydrates"
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0044238 ! primary metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:16646 ! has primary input or output carbohydrate
relationship: RO:0004007 CHEBI:16646 ! has primary input or output carbohydrate
creation_date: 2012-10-23T15:40:34Z

[Term]
id: GO:0005976
name: polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684]
subset: goslim_pir
synonym: "glycan metabolic process" NARROW []
synonym: "glycan metabolism" NARROW []
synonym: "multicellular organismal polysaccharide metabolic process" NARROW []
synonym: "polysaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:18154 ! has primary input or output polysaccharide
relationship: RO:0004007 CHEBI:18154 ! has primary input or output polysaccharide

[Term]
id: GO:0006022
name: aminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan
relationship: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan

[Term]
id: GO:0006023
name: aminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan anabolism" EXACT []
synonym: "aminoglycan biosynthesis" EXACT []
synonym: "aminoglycan formation" EXACT []
synonym: "aminoglycan synthesis" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:22506 ! has primary output aminoglycan
relationship: RO:0004008 CHEBI:22506 ! has primary output aminoglycan

[Term]
id: GO:0006024
name: glycosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384]
synonym: "glycosaminoglycan anabolism" EXACT []
synonym: "glycosaminoglycan biosynthesis" EXACT []
synonym: "glycosaminoglycan formation" EXACT []
synonym: "glycosaminoglycan synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18085 ! has primary output
relationship: RO:0004008 CHEBI:18085 ! has primary output

[Term]
id: GO:0006026
name: aminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan breakdown" EXACT []
synonym: "aminoglycan catabolism" EXACT []
synonym: "aminoglycan degradation" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:22506 ! has primary input aminoglycan
relationship: RO:0004009 CHEBI:22506 ! has primary input aminoglycan

[Term]
id: GO:0006027
name: glycosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384]
synonym: "glycosaminoglycan breakdown" EXACT []
synonym: "glycosaminoglycan catabolism" EXACT []
synonym: "glycosaminoglycan degradation" EXACT []
xref: Reactome:R-HSA-2024101 "CS/DS degradation"
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:18085 ! has primary input
relationship: RO:0004009 CHEBI:18085 ! has primary input

[Term]
id: GO:0006033
name: chitin localization
namespace: biological_process
def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "chitin localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chitin localization" EXACT []
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0006066
name: alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
synonym: "alcohol metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006082
name: organic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: goslim_pir
synonym: "organic acid metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:64709 ! has primary input or output organic acid
relationship: RO:0004007 CHEBI:64709 ! has primary input or output organic acid

[Term]
id: GO:0006109
name: regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
synonym: "regulation of carbohydrate metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process
relationship: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process

[Term]
id: GO:0006139
name: nucleobase-containing compound metabolic process
namespace: biological_process
alt_id: GO:0055134
def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
subset: goslim_pir
subset: goslim_plant
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0044238 ! primary metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:61120 ! has primary input or output nucleobase-containing molecular entity
relationship: RO:0004007 CHEBI:61120 ! has primary input or output nucleobase-containing molecular entity

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "cellular DNA metabolism" EXACT []
synonym: "DNA metabolism" EXACT []
is_a: GO:0090304 ! nucleic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:16991 ! has primary input or output
relationship: RO:0004007 CHEBI:16991 ! has primary input or output

[Term]
id: GO:0006308
name: DNA catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]
synonym: "DNA breakdown" EXACT []
synonym: "DNA catabolism" EXACT []
synonym: "DNA degradation" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0141188 ! nucleic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:16991 ! has primary input
relationship: BFO:0000051 GO:0004536 ! has part DNA nuclease activity
relationship: RO:0004009 CHEBI:16991 ! has primary input

[Term]
id: GO:0006309
name: apoptotic DNA fragmentation
namespace: biological_process
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis]
synonym: "DNA catabolic process during apoptosis" EXACT []
synonym: "DNA catabolism during apoptosis" EXACT []
synonym: "DNA fragmentation" BROAD []
synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb]
synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT []
xref: Reactome:R-HSA-140342 "Apoptosis induced DNA fragmentation"
is_a: GO:0006308 ! DNA catabolic process
intersection_of: GO:0006308 ! DNA catabolic process
intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes
relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes

[Term]
id: GO:0006325
name: chromatin organization
namespace: biological_process
def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "chromatin assembly" NARROW []
synonym: "chromatin assembly or disassembly" RELATED []
synonym: "chromatin assembly/disassembly" RELATED []
synonym: "chromatin maintenance" BROAD []
synonym: "chromatin modification" RELATED []
synonym: "chromatin organisation" EXACT [GOC:mah]
synonym: "DNA replication-independent chromatin assembly" NARROW []
synonym: "DNA replication-independent chromatin organization" NARROW []
synonym: "DNA replication-independent nucleosome organisation" NARROW []
synonym: "DNA replication-independent nuclesome assembly" NARROW []
synonym: "establishment of chromatin architecture" EXACT [GOC:mah]
synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah]
synonym: "transcription-coupled nucleosome assembly" NARROW []
xref: Reactome:R-HSA-4839726 "Chromatin organization"
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin
relationship: RO:0002592 GO:0000785 ! results in organization of chromatin

[Term]
id: GO:0006338
name: chromatin remodeling
namespace: biological_process
def: "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
synonym: "ATP-dependent chromatin remodeling" NARROW []
synonym: "ATP-dependent chromatin remodelling" NARROW []
synonym: "chromatin modeling" EXACT []
synonym: "chromatin modelling" EXACT []
synonym: "chromatin remodelling" EXACT []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0006399
name: tRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
synonym: "tRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0006401
name: RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_yeast
synonym: "RNA breakdown" EXACT []
synonym: "RNA catabolism" EXACT []
synonym: "RNA degradation" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0141188 ! nucleic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid

[Term]
id: GO:0006403
name: RNA localization
namespace: biological_process
def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
subset: goslim_drosophila
synonym: "establishment and maintenance of RNA localization" EXACT []
synonym: "RNA localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0006404
name: RNA import into nucleus
namespace: biological_process
def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma]
synonym: "RNA import into cell nucleus" EXACT []
synonym: "RNA transport from cytoplasm to nucleus" EXACT []
synonym: "RNA-nucleus import" EXACT []
is_a: GO:0050658 ! RNA transport
is_a: GO:0051170 ! import into nucleus
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid

[Term]
id: GO:0006405
name: RNA export from nucleus
namespace: biological_process
def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "RNA export from cell nucleus" EXACT []
synonym: "RNA export out of nucleus" EXACT []
synonym: "RNA transport from nucleus to cytoplasm" EXACT []
synonym: "RNA-nucleus export" EXACT []
is_a: GO:0050658 ! RNA transport
is_a: GO:0051168 ! nuclear export
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid

[Term]
id: GO:0006409
name: tRNA export from nucleus
namespace: biological_process
def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "tRNA export from cell nucleus" EXACT []
synonym: "tRNA export out of nucleus" EXACT []
synonym: "tRNA transport from nucleus to cytoplasm" EXACT []
synonym: "tRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051031 ! tRNA transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0004009 CHEBI:17843 ! has primary input

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein biosynthetic process" EXACT []
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Reactome:R-HSA-72766 "Translation"
xref: Wikipedia:Translation_(genetics)
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: BFO:0000050 GO:0010467 ! part of gene expression
intersection_of: BFO:0000050 GO:0010467 ! part of gene expression
intersection_of: BFO:0000051 GO:0000048 ! has part peptidyltransferase activity
intersection_of: RO:0004008 CHEBI:36080 ! has primary output protein
intersection_of: RO:0004008 PR:000000001 ! has primary output protein
relationship: BFO:0000050 GO:0160307 ! part of protein biosynthetic process
relationship: BFO:0000051 GO:0000048 ! has part peptidyltransferase activity
relationship: BFO:0000051 GO:0006414 ! has part translational elongation
relationship: RO:0002224 GO:0006413 ! starts with translational initiation
relationship: RO:0002230 GO:0006415 ! ends with translational termination
relationship: RO:0004008 CHEBI:36080 ! has primary output protein
relationship: RO:0004008 PR:000000001 ! has primary output protein

[Term]
id: GO:0006413
name: translational initiation
namespace: biological_process
alt_id: GO:0006440
alt_id: GO:0006454
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
subset: goslim_yeast
synonym: "biopolymerisation" BROAD []
synonym: "biopolymerization" BROAD []
synonym: "protein synthesis initiation" BROAD []
synonym: "translation initiation" EXACT []
xref: Reactome:R-HSA-72613 "Eukaryotic Translation Initiation"
is_a: GO:0008152 ! metabolic process
relationship: BFO:0000050 GO:0006412 ! part of translation
relationship: RO:0002224 GO:0001677 ! starts with formation of translation initiation ternary complex

[Term]
id: GO:0006414
name: translational elongation
namespace: biological_process
alt_id: GO:0006442
alt_id: GO:0006455
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
subset: goslim_yeast
synonym: "protein synthesis elongation" BROAD []
synonym: "translation elongation" EXACT []
xref: Reactome:R-HSA-156842 "Eukaryotic Translation Elongation"
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: BFO:0000050 GO:0006412 ! part of translation

[Term]
id: GO:0006415
name: translational termination
namespace: biological_process
alt_id: GO:0006443
alt_id: GO:0006456
def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
synonym: "protein synthesis termination" BROAD []
synonym: "translation termination" EXACT []
synonym: "translational complex disassembly" EXACT []
xref: Reactome:R-HSA-72764 "Eukaryotic Translation Termination"
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: BFO:0000050 GO:0006412 ! part of translation

[Term]
id: GO:0006417
name: regulation of translation
namespace: biological_process
alt_id: GO:0006445
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]
subset: goslim_yeast
synonym: "regulation of protein anabolism" EXACT []
synonym: "regulation of protein biosynthesis" EXACT []
synonym: "regulation of protein formation" EXACT []
synonym: "regulation of protein synthesis" EXACT []
is_a: GO:0010608 ! post-transcriptional regulation of gene expression
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006412 ! regulates translation
relationship: RO:0002211 GO:0006412 ! regulates translation

[Term]
id: GO:0006446
name: regulation of translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation
relationship: RO:0002211 GO:0006413 ! regulates translational initiation

[Term]
id: GO:0006448
name: regulation of translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006414 ! regulates translational elongation
relationship: RO:0002211 GO:0006414 ! regulates translational elongation

[Term]
id: GO:0006449
name: regulation of translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006415 ! regulates translational termination
relationship: RO:0002211 GO:0006415 ! regulates translational termination

[Term]
id: GO:0006468
name: protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a protein." [GOC:hb]
subset: gocheck_obsoletion_candidate
subset: goslim_yeast
synonym: "protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0016310 ! phosphorylation
is_a: GO:0036211 ! protein modification process

[Term]
id: GO:0006508
name: proteolysis
namespace: biological_process
def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing.
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
synonym: "ATP-dependent proteolysis" NARROW [GOC:mah]
synonym: "peptidolysis" EXACT []
xref: Wikipedia:Proteolysis
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0006516
name: glycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
synonym: "glycoprotein breakdown" EXACT []
synonym: "glycoprotein catabolism" EXACT []
synonym: "glycoprotein degradation" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:0030163 ! protein catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:17089 ! has primary input
relationship: RO:0004009 CHEBI:17089 ! has primary input

[Term]
id: GO:0006518
name: peptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]
subset: goslim_pir
synonym: "peptide metabolism" EXACT []
xref: Reactome:R-HSA-2980736 "Peptide hormone metabolism"
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:60466 ! has primary input or output peptide zwitterion
relationship: RO:0004007 CHEBI:60466 ! has primary input or output peptide zwitterion

[Term]
id: GO:0006520
name: amino acid metabolic process
namespace: biological_process
alt_id: GO:0006519
def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "amino acid and derivative metabolism" RELATED []
synonym: "cellular amino acid and derivative metabolic process" RELATED []
synonym: "cellular amino acid metabolic process" EXACT []
synonym: "cellular amino acid metabolism" EXACT []
is_a: GO:0044238 ! primary metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:35238 ! has primary input or output amino-acid zwitterion
relationship: RO:0004007 CHEBI:35238 ! has primary input or output amino-acid zwitterion

[Term]
id: GO:0006521
name: regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators]
synonym: "regulation of amino acid metabolism" EXACT []
xref: Reactome:R-HSA-350562 "Regulation of ornithine decarboxylase (ODC)"
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006520 ! regulates amino acid metabolic process
relationship: RO:0002211 GO:0006520 ! regulates amino acid metabolic process

[Term]
id: GO:0006536
name: glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
synonym: "glutamate metabolism" EXACT []
synonym: "glutamic acid metabolic process" EXACT []
synonym: "glutamic acid metabolism" EXACT []
xref: Wikipedia:Glutamic_acid
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:14321 ! has primary input or output
relationship: RO:0004007 CHEBI:14321 ! has primary input or output

[Term]
id: GO:0006537
name: glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
synonym: "glutamate anabolism" EXACT []
synonym: "glutamate biosynthesis" EXACT []
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate formation" EXACT []
synonym: "glutamate synthesis" EXACT []
synonym: "glutamic acid biosynthesis" EXACT []
synonym: "glutamic acid biosynthetic process" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:14321 ! has primary output
relationship: RO:0004008 CHEBI:14321 ! has primary output

[Term]
id: GO:0006538
name: L-glutamate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
synonym: "glutamate breakdown" EXACT []
synonym: "glutamate catabolism" EXACT []
synonym: "glutamate deamidation" RELATED []
synonym: "glutamate degradation" EXACT []
synonym: "glutamic acid catabolic process" EXACT []
synonym: "glutamic acid catabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0170035 ! L-amino acid catabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
relationship: RO:0004009 CHEBI:29985 ! has primary input

[Term]
id: GO:0006544
name: glycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine metabolism" EXACT []
is_a: GO:0170039 ! proteinogenic amino acid metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:57305 ! has primary input or output
relationship: RO:0004007 CHEBI:57305 ! has primary input or output

[Term]
id: GO:0006545
name: glycine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine anabolism" EXACT []
synonym: "glycine biosynthesis" EXACT []
synonym: "glycine formation" EXACT []
synonym: "glycine synthesis" EXACT []
xref: MetaCyc:GLYCINE-SYN2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:57305 ! has primary output
relationship: RO:0004008 CHEBI:57305 ! has primary output

[Term]
id: GO:0006546
name: glycine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine breakdown" EXACT []
synonym: "glycine catabolism" EXACT []
synonym: "glycine degradation" EXACT []
xref: Reactome:R-HSA-6783984 "Glycine degradation"
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0170040 ! proteinogenic amino acid catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
relationship: RO:0004009 CHEBI:57305 ! has primary input

[Term]
id: GO:0006553
name: lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
synonym: "lysine metabolism" EXACT []
xref: Wikipedia:Lysine
is_a: GO:1901605 ! alpha-amino acid metabolic process

[Term]
id: GO:0006576
name: biogenic amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
synonym: "biogenic amine metabolism" EXACT []
synonym: "cellular biogenic amine metabolic process" EXACT []
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0006581
name: acetylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine breakdown" EXACT []
synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: RO:0004009 CHEBI:15355 ! has primary input

[Term]
id: GO:0006584
name: catecholamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33567 ! has primary input or output
relationship: RO:0004007 CHEBI:33567 ! has primary input or output

[Term]
id: GO:0006606
name: protein import into nucleus
namespace: biological_process
def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah]
synonym: "protein import into cell nucleus" EXACT []
synonym: "protein nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0034504 ! protein localization to nucleus
is_a: GO:0051170 ! import into nucleus
is_a: GO:0072594 ! establishment of protein localization to organelle
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0006611
name: protein export from nucleus
namespace: biological_process
def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
synonym: "copper-induced protein export from nucleus" RELATED [GOC:al]
synonym: "protein export from cell nucleus" EXACT []
synonym: "protein export out of nucleus" EXACT []
synonym: "protein transport from nucleus to cytoplasm" EXACT []
synonym: "protein-nucleus export" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0051168 ! nuclear export
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "lipid metabolism" EXACT []
xref: Reactome:R-HSA-556833 "Metabolism of lipids"
xref: Wikipedia:Lipid_metabolism
is_a: GO:0044238 ! primary metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output lipid
relationship: RO:0004007 CHEBI:18059 ! has primary input or output lipid

[Term]
id: GO:0006643
name: membrane lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
synonym: "membrane lipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane
intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output lipid
relationship: BFO:0000066 GO:0016020 ! occurs in membrane

[Term]
id: GO:0006694
name: steroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
synonym: "steroid anabolism" EXACT []
synonym: "steroid biosynthesis" EXACT []
synonym: "steroid formation" EXACT []
synonym: "steroid synthesis" EXACT []
synonym: "steroidogenesis" EXACT []
xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:35341 ! has primary output steroid
relationship: RO:0004008 CHEBI:35341 ! has primary output steroid

[Term]
id: GO:0006706
name: steroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]
synonym: "steroid breakdown" EXACT []
synonym: "steroid catabolism" EXACT []
synonym: "steroid degradation" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016042 ! lipid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:35341 ! has primary input steroid
relationship: RO:0004009 CHEBI:35341 ! has primary input steroid

[Term]
id: GO:0006714
name: sesquiterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684]
synonym: "sesquiterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0006720
name: isoprenoid metabolic process
namespace: biological_process
alt_id: GO:0016096
def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]
synonym: "isoprenoid metabolism" EXACT []
synonym: "polyisoprenoid metabolic process" NARROW []
synonym: "polyisoprenoid metabolism" NARROW []
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0006721
name: terpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732]
synonym: "terpenoid metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0006793
name: phosphorus metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]
subset: goslim_pir
synonym: "phosphorus metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26082 ! has primary input or output phosphorus molecular entity
relationship: RO:0004007 CHEBI:26082 ! has primary input or output phosphorus molecular entity

[Term]
id: GO:0006796
name: phosphate-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
synonym: "phosphate metabolic process" RELATED []
synonym: "phosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26020 ! has primary input or output phosphate
relationship: RO:0004007 CHEBI:26020 ! has primary input or output phosphate

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
alt_id: GO:0044765
def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "single-organism transport" RELATED []
xref: Reactome:R-HSA-382551 "Transport of small molecules"
is_a: GO:0051234 ! establishment of localization
created_by: jl
creation_date: 2012-12-13T16:25:32Z

[Term]
id: GO:0006811
name: monoatomic ion transport
namespace: biological_process
def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "ion transport" BROAD []
xref: Reactome:R-HSA-425393 "Transport of inorganic cations/anions and amino acids/oligopeptides"
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion
relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion

[Term]
id: GO:0006835
name: dicarboxylic acid transport
namespace: biological_process
def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sodium:dicarboxylate transport" RELATED []
is_a: GO:0046942 ! carboxylic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion
relationship: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion

[Term]
id: GO:0006836
name: neurotransmitter transport
namespace: biological_process
def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
subset: goslim_pir
synonym: "sodium:neurotransmitter transport" NARROW []
xref: Reactome:R-HSA-181429 "Serotonin Neurotransmitter Release Cycle"
xref: Reactome:R-HSA-181430 "Norepinephrine Neurotransmitter Release Cycle"
xref: Reactome:R-HSA-210500 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:R-HSA-212676 "Dopamine Neurotransmitter Release Cycle"
xref: Reactome:R-HSA-264642 "Acetylcholine Neurotransmitter Release Cycle"
is_a: GO:0006810 ! transport
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0006837
name: serotonin transport
namespace: biological_process
def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:350546 ! has primary input
relationship: RO:0004009 CHEBI:350546 ! has primary input

[Term]
id: GO:0006839
name: mitochondrial transport
namespace: biological_process
def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai]
subset: goslim_drosophila
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002344 GO:0005739 ! results in transport to from or in mitochondrion
relationship: RO:0002344 GO:0005739 ! results in transport to from or in mitochondrion

[Term]
id: GO:0006858
name: extracellular transport
namespace: biological_process
def: "The transport of substances that occurs outside cells." [GOC:go_curators]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region
relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region

[Term]
id: GO:0006860
name: extracellular amino acid transport
namespace: biological_process
def: "The directed extracellular movement of amino acids." [GOC:ai]
is_a: GO:0006858 ! extracellular transport
is_a: GO:0006865 ! amino acid transport
intersection_of: GO:0006865 ! amino acid transport
intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region

[Term]
id: GO:0006865
name: amino acid transport
namespace: biological_process
alt_id: GO:0006866
def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
xref: Reactome:R-HSA-352230 "Amino acid transport across the plasma membrane"
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0006869
name: lipid transport
namespace: biological_process
def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
xref: Reactome:R-HSA-1369062 "ABC transporters in lipid homeostasis"
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: BFO:0000050 GO:0010876 ! part of lipid localization
relationship: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0006886
name: intracellular protein transport
namespace: biological_process
alt_id: GO:0032779
def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "copper-induced intracellular protein transport" RELATED [GOC:al]
is_a: GO:0015031 ! protein transport
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: BFO:0000050 GO:0008104 ! part of intracellular protein localization

[Term]
id: GO:0006887
name: exocytosis
namespace: biological_process
def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]
subset: goslim_yeast
synonym: "nonselective vesicle exocytosis" RELATED []
synonym: "vesicle exocytosis" EXACT []
xref: Wikipedia:Exocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle
relationship: BFO:0000051 GO:0099500 ! has part vesicle fusion to plasma membrane
relationship: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle

[Term]
id: GO:0006892
name: post-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]
synonym: "post-Golgi transport" EXACT []
xref: Reactome:R-HSA-199992 "trans-Golgi Network Vesicle Budding"
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006893
name: Golgi to plasma membrane transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]
synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus

[Term]
id: GO:0006896
name: Golgi to vacuole transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai]
synonym: "Golgi to vacuole vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0007034 ! vacuolar transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole
relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
relationship: RO:0002339 GO:0005773 ! has target end location vacuole

[Term]
id: GO:0006897
name: endocytosis
namespace: biological_process
alt_id: GO:0016193
alt_id: GO:0016196
alt_id: GO:0098701
def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]
subset: goslim_yeast
synonym: "endocytic import into cell" EXACT []
synonym: "nonselective vesicle endocytosis" RELATED []
synonym: "plasma membrane invagination" NARROW []
synonym: "vesicle endocytosis" EXACT []
xref: Wikipedia:Endocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0098657 ! import into cell
relationship: BFO:0000051 GO:0006900 ! has part vesicle budding from membrane
relationship: BFO:0000051 GO:0010324 ! has part membrane invagination
relationship: RO:0002339 GO:0031410 ! has target end location cytoplasmic vesicle

[Term]
id: GO:0006900
name: vesicle budding from membrane
namespace: biological_process
alt_id: GO:0006902
alt_id: GO:1902591
def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]
synonym: "membrane evagination" EXACT []
synonym: "nonselective vesicle assembly" RELATED []
synonym: "single organism membrane budding" RELATED [GOC:TermGenie]
synonym: "single-organism membrane budding" RELATED []
synonym: "vesicle biosynthesis" EXACT []
synonym: "vesicle budding" RELATED []
synonym: "vesicle formation" EXACT []
is_a: GO:0016050 ! vesicle organization
is_a: GO:0061024 ! membrane organization
relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport
created_by: jl
creation_date: 2013-12-19T15:26:17Z

[Term]
id: GO:0006903
name: vesicle targeting
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]
is_a: GO:0009987 ! cellular process
relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport
relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localization

[Term]
id: GO:0006906
name: vesicle fusion
namespace: biological_process
def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane
relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport
relationship: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane

[Term]
id: GO:0006909
name: phagocytosis
namespace: biological_process
def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
xref: Reactome:R-HSA-9664417 "Leishmania phagocytosis"
xref: Wikipedia:Phagocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006913
name: nucleocytoplasmic transport
namespace: biological_process
def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
synonym: "nucleocytoplasmic shuttling" NARROW []
is_a: GO:0051169 ! nuclear transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0002344 GO:0005829 ! results in transport to from or in cytosol
intersection_of: RO:0002344 GO:0031981 ! results in transport to from or in nuclear lumen
relationship: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
relationship: RO:0002344 GO:0005829 ! results in transport to from or in cytosol
relationship: RO:0002344 GO:0031981 ! results in transport to from or in nuclear lumen

[Term]
id: GO:0006914
name: autophagy
namespace: biological_process
alt_id: GO:0016238
def: "The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
xref: Reactome:R-HSA-9612973 "Autophagy"
xref: Wikipedia:Autophagy_(cellular)
is_a: GO:0009056 ! catabolic process
is_a: GO:0061919 ! process utilizing autophagic mechanism
relationship: BFO:0000051 GO:0055085 ! has part transmembrane transport

[Term]
id: GO:0006915
name: apoptotic process
namespace: biological_process
def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
synonym: "activation of apoptosis" NARROW []
synonym: "apoptosis" NARROW []
synonym: "apoptosis activator activity" RELATED []
synonym: "apoptosis signaling" NARROW []
synonym: "apoptotic cell death" EXACT [GOC:sl]
synonym: "apoptotic program" NARROW [GOC:add]
synonym: "apoptotic programmed cell death" EXACT []
synonym: "caspase-dependent programmed cell death" RELATED []
synonym: "cell suicide" BROAD []
synonym: "cellular suicide" BROAD []
synonym: "commitment to apoptosis" RELATED []
synonym: "induction of apoptosis" RELATED []
synonym: "induction of apoptosis by p53" RELATED []
synonym: "programmed cell death by apoptosis" EXACT []
synonym: "signaling (initiator) caspase activity" RELATED []
synonym: "type I programmed cell death" NARROW []
xref: Reactome:R-HSA-109581 "Apoptosis"
xref: Wikipedia:Apoptosis
is_a: GO:0012501 ! programmed cell death
relationship: RO:0002224 GO:0097190 ! starts with apoptotic signaling pathway
relationship: RO:0002230 GO:0097194 ! ends with execution phase of apoptosis

[Term]
id: GO:0006921
name: cellular component disassembly involved in execution phase of apoptosis
namespace: biological_process
def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb]
synonym: "cellular component disassembly involved in apoptosis" NARROW []
synonym: "cellular component disassembly involved in apoptotic process" BROAD []
synonym: "disassembly of cell structures" BROAD []
is_a: GO:0022411 ! cellular component disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis
relationship: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis

[Term]
id: GO:0006925
name: inflammatory cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis]
synonym: "apoptosis of inflammatory cells" EXACT []
synonym: "inflammatory cell apoptosis" NARROW []
synonym: "inflammatory cell programmed cell death by apoptosis" EXACT []
synonym: "killing of inflammatory cells" EXACT []
synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT []
synonym: "programmed cell death, inflammatory cells" EXACT []
xref: Reactome:R-HSA-168277 "Influenza Virus Induced Apoptosis"
is_a: GO:0006915 ! apoptotic process

[Term]
id: GO:0006935
name: chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]
synonym: "taxis in response to chemical stimulus" EXACT []
xref: Wikipedia:Chemotaxis
is_a: GO:0042330 ! taxis
relationship: BFO:0000050 GO:0042221 ! part of response to chemical

[Term]
id: GO:0006936
name: muscle contraction
namespace: biological_process
def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
subset: goslim_pir
xref: Reactome:R-HSA-445355 "Smooth Muscle Contraction"
xref: Wikipedia:Muscle_contraction
is_a: GO:0003012 ! muscle system process
relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue

[Term]
id: GO:0006937
name: regulation of muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006936 ! regulates muscle contraction
relationship: RO:0002211 GO:0006936 ! regulates muscle contraction

[Term]
id: GO:0006939
name: smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "visceral muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue
relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue

[Term]
id: GO:0006940
name: regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006939 ! regulates smooth muscle contraction
relationship: RO:0002211 GO:0006939 ! regulates smooth muscle contraction

[Term]
id: GO:0006941
name: striated muscle contraction
namespace: biological_process
def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "sarcomeric muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction
relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue

[Term]
id: GO:0006942
name: regulation of striated muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006941 ! regulates striated muscle contraction
relationship: RO:0002211 GO:0006941 ! regulates striated muscle contraction

[Term]
id: GO:0006949
name: syncytium formation
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 CL:0000228 ! results in formation of multinucleate cell
relationship: RO:0002297 CL:0000228 ! results in formation of multinucleate cell

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006952
name: defense response
namespace: biological_process
alt_id: GO:0002217
alt_id: GO:0042829
def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
synonym: "antimicrobial peptide activity" RELATED []
synonym: "defence response" EXACT []
synonym: "defense/immunity protein activity" RELATED []
synonym: "physiological defense response" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006954
name: inflammatory response
namespace: biological_process
def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732]
subset: goslim_generic
synonym: "inflammation" BROAD []
xref: Wikipedia:Inflammation
is_a: GO:0006952 ! defense response
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>

[Term]
id: GO:0006955
name: immune response
namespace: biological_process
def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006979
name: response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
subset: goslim_yeast
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
alt_id: GO:1902589
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "organelle organisation" EXACT []
synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah]
synonym: "single organism organelle organization" EXACT [GOC:TermGenie]
synonym: "single-organism organelle organization" RELATED []
xref: Reactome:R-HSA-1852241 "Organelle biogenesis and maintenance"
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0043226 ! results in organization of organelle
relationship: RO:0002592 GO:0043226 ! results in organization of organelle
created_by: jl
creation_date: 2013-12-19T15:25:51Z

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT []
synonym: "nuclear organization" EXACT []
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005634 ! results in organization of nucleus
relationship: RO:0002592 GO:0005634 ! results in organization of nucleus

[Term]
id: GO:0006998
name: nuclear envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
synonym: "nuclear envelope organisation" EXACT [GOC:mah]
synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005635 ! results in organization of nuclear envelope
relationship: BFO:0000050 GO:0006997 ! part of nucleus organization
relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization
relationship: RO:0002592 GO:0005635 ! results in organization of nuclear envelope

[Term]
id: GO:0007000
name: nucleolus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
synonym: "nucleolus organisation" EXACT []
synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005730 ! results in organization of nucleolus
relationship: RO:0002592 GO:0005730 ! results in organization of nucleolus

[Term]
id: GO:0007005
name: mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "mitochondria organization" EXACT [GOC:mah]
synonym: "mitochondrial biogenesis" EXACT []
synonym: "mitochondrial organization" EXACT []
synonym: "mitochondrion biogenesis" EXACT []
synonym: "mitochondrion morphogenesis" RELATED []
synonym: "mitochondrion organisation" EXACT [GOC:mah]
synonym: "mitochondrion organization and biogenesis" RELATED []
xref: Reactome:R-HSA-1592230 "Mitochondrial biogenesis"
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005739 ! results in organization of mitochondrion
relationship: RO:0002592 GO:0005739 ! results in organization of mitochondrion

[Term]
id: GO:0007006
name: mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "mitochondrial membrane organisation" EXACT []
synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0061024 ! membrane organization
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0007008
name: outer mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'.
synonym: "outer mitochondrial membrane organisation" EXACT []
synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007006 ! mitochondrial membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005741 ! results in organization of mitochondrial outer membrane
relationship: RO:0002592 GO:0005741 ! results in organization of mitochondrial outer membrane

[Term]
id: GO:0007009
name: plasma membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
synonym: "plasma membrane organisation" EXACT []
synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005886 ! results in organization of plasma membrane
relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization
relationship: RO:0002592 GO:0005886 ! results in organization of plasma membrane

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT []
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005856 ! results in organization of cytoskeleton
relationship: RO:0002592 GO:0005856 ! results in organization of cytoskeleton

[Term]
id: GO:0007015
name: actin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
synonym: "actin filament organisation" EXACT []
synonym: "regulation of actin filament localization" NARROW []
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005884 ! results in organization of actin filament
relationship: BFO:0000050 GO:0030036 ! part of actin cytoskeleton organization
relationship: RO:0002592 GO:0005884 ! results in organization of actin filament

[Term]
id: GO:0007017
name: microtubule-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_chembl
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule
relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule

[Term]
id: GO:0007018
name: microtubule-based movement
namespace: biological_process
def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]
subset: goslim_drosophila
subset: goslim_generic
xref: Reactome:R-HSA-983189 "Kinesins"
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0007019
name: microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule depolymerization during nuclear congression" NARROW []
synonym: "microtubule disassembly" EXACT []
synonym: "microtubule shortening" EXACT []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005874 ! results in disassembly of microtubule
relationship: RO:0002590 GO:0005874 ! results in disassembly of microtubule

[Term]
id: GO:0007020
name: microtubule nucleation
namespace: biological_process
def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]
xref: Wikipedia:Microtubule_nucleation
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: BFO:0000050 GO:0046785 ! part of microtubule polymerization

[Term]
id: GO:0007026
name: negative regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
synonym: "down regulation of microtubule depolymerization" EXACT []
synonym: "down-regulation of microtubule depolymerization" EXACT []
synonym: "downregulation of microtubule depolymerization" EXACT []
synonym: "inhibition of microtubule depolymerization" NARROW []
synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of microtubule disassembly" EXACT []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901880 ! negative regulation of protein depolymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization
relationship: RO:0002212 GO:0007019 ! negatively regulates microtubule depolymerization

[Term]
id: GO:0007027
name: negative regulation of axonemal microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah]
synonym: "axonemal microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph]
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization
relationship: RO:0002212 GO:0060404 ! negatively regulates axonemal microtubule depolymerization

[Term]
id: GO:0007028
name: cytoplasm organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "cytoplasm organisation" EXACT []
synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005737 ! results in organization of cytoplasm
relationship: RO:0002592 GO:0005737 ! results in organization of cytoplasm

[Term]
id: GO:0007030
name: Golgi organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "Golgi apparatus organization" EXACT []
synonym: "Golgi organisation" EXACT []
synonym: "Golgi organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus
relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization
relationship: RO:0002592 GO:0005794 ! results in organization of Golgi apparatus

[Term]
id: GO:0007033
name: vacuole organization
namespace: biological_process
alt_id: GO:0044086
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "vacuolar assembly" NARROW [GOC:mah]
synonym: "vacuole biogenesis" RELATED [GOC:mah]
synonym: "vacuole organisation" EXACT []
synonym: "vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005773 ! results in organization of vacuole
relationship: RO:0002592 GO:0005773 ! results in organization of vacuole

[Term]
id: GO:0007034
name: vacuolar transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai]
subset: goslim_chembl
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole
relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole

[Term]
id: GO:0007039
name: protein catabolic process in the vacuole
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw]
synonym: "vacuolar protein breakdown" RELATED []
synonym: "vacuolar protein catabolic process" RELATED []
synonym: "vacuolar protein catabolism" RELATED []
synonym: "vacuolar protein degradation" RELATED []
is_a: GO:0030163 ! protein catabolic process
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole
relationship: BFO:0000066 GO:0005773 ! occurs in vacuole

[Term]
id: GO:0007040
name: lysosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
subset: goslim_generic
synonym: "lysosome organisation" EXACT []
synonym: "lysosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0080171 ! lytic vacuole organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005764 ! results in organization of lysosome
relationship: RO:0002592 GO:0005764 ! results in organization of lysosome

[Term]
id: GO:0007041
name: lysosomal transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai]
is_a: GO:0007034 ! vacuolar transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002344 GO:0005764 ! results in transport to from or in lysosome
relationship: RO:0002344 GO:0005764 ! results in transport to from or in lysosome

[Term]
id: GO:0007043
name: cell-cell junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
synonym: "intercellular junction assembly" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0045216 ! cell-cell junction organization
intersection_of: GO:0034329 ! cell junction assembly
intersection_of: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction
relationship: RO:0002588 GO:0005911 ! results in assembly of cell-cell junction

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cell-division cycle" EXACT []
xref: Reactome:R-HSA-1640170 "Cell Cycle"
xref: Wikipedia:Cell_cycle
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007059
name: chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "chromosome division" EXACT []
synonym: "chromosome transmission" RELATED []
xref: Wikipedia:Chromosome_segregation
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0007076
name: mitotic chromosome condensation
namespace: biological_process
def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
xref: Reactome:R-HSA-2299718 "Condensation of Prophase Chromosomes"
xref: Reactome:R-HSA-2514853 "Condensation of Prometaphase Chromosomes"
is_a: GO:0030261 ! chromosome condensation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0030261 ! chromosome condensation
intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle
relationship: BFO:0000050 GO:0000070 ! part of mitotic sister chromatid segregation

[Term]
id: GO:0007077
name: mitotic nuclear membrane disassembly
namespace: biological_process
def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252]
synonym: "local NEB" BROAD []
synonym: "mitotic nuclear envelope breakdown" EXACT []
synonym: "mitotic nuclear envelope catabolism" RELATED []
synonym: "mitotic nuclear envelope degradation" RELATED []
synonym: "mitotic nuclear envelope disassembly" RELATED []
synonym: "NEB" BROAD []
synonym: "nuclear envelope breakdown" BROAD []
xref: Reactome:R-HSA-2980766 "Nuclear Envelope Breakdown"
is_a: GO:0051081 ! nuclear membrane disassembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle

[Term]
id: GO:0007088
name: regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "regulation of mitosis" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0140014 ! regulates mitotic nuclear division
relationship: RO:0002211 GO:0140014 ! regulates mitotic nuclear division

[Term]
id: GO:0007097
name: nuclear migration
namespace: biological_process
alt_id: GO:0040023
def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
synonym: "establishment of cell nucleus localization" RELATED []
synonym: "establishment of localization of nucleus" RELATED []
synonym: "establishment of nucleus localisation" RELATED [GOC:mah]
synonym: "establishment of nucleus localization" RELATED []
synonym: "establishment of position of nucleus" EXACT []
synonym: "nuclear movement" EXACT []
synonym: "nuclear positioning" EXACT []
synonym: "nucleus migration" EXACT []
synonym: "nucleus positioning" EXACT []
synonym: "positioning of nucleus" EXACT []
is_a: GO:0046907 ! intracellular transport
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus

[Term]
id: GO:0007113
name: endomitotic cell cycle
namespace: biological_process
def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins.
synonym: "endomitosis" RELATED []
xref: Wikipedia:Mitosis#Endomitosis
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007127
name: meiosis I
namespace: biological_process
def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]
synonym: "meiosis I nuclear division" EXACT []
xref: Wikipedia:Meiosis#Meiosis_I
is_a: GO:0061982 ! meiosis I cell cycle process
is_a: GO:0140013 ! meiotic nuclear division
relationship: RO:0002093 GO:0007134 ! ends during meiotic telophase I

[Term]
id: GO:0007134
name: meiotic telophase I
namespace: biological_process
def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0051326 ! telophase
is_a: GO:0098764 ! meiosis I cell cycle phase

[Term]
id: GO:0007135
name: meiosis II
namespace: biological_process
def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684]
synonym: "meiosis II nuclear division" EXACT []
xref: Wikipedia:Meiosis#Meiosis_II
is_a: GO:0061983 ! meiosis II cell cycle process
is_a: GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0007143
name: female meiotic nuclear division
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw]
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'.
synonym: "female meiosis" BROAD []
synonym: "female meiotic division" BROAD []
is_a: GO:0140013 ! meiotic nuclear division
intersection_of: GO:0000280 ! nuclear division
intersection_of: BFO:0000050 GO:0007292 ! part of female gamete generation
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle
relationship: BFO:0000050 GO:0007292 ! part of female gamete generation

[Term]
id: GO:0007147
name: female meiosis II
namespace: biological_process
def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah]
synonym: "female meiosis II nuclear division" EXACT []
is_a: GO:0007135 ! meiosis II
is_a: GO:0007143 ! female meiotic nuclear division
intersection_of: GO:0007135 ! meiosis II
intersection_of: BFO:0000050 GO:0007292 ! part of female gamete generation
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle

[Term]
id: GO:0007154
name: cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
subset: goslim_pir
subset: goslim_plant
xref: Wikipedia:Cell_signaling
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cell adhesion molecule activity" RELATED []
synonym: "single organism cell adhesion" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0009987 ! cellular process
creation_date: 2014-04-15T15:59:10Z

[Term]
id: GO:0007159
name: leukocyte cell-cell adhesion
namespace: biological_process
def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators]
synonym: "leukocyte adhesion" EXACT []
synonym: "leukocyte cell adhesion" EXACT []
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: RO:0000057 CL:0000738 ! has participant leukocyte
relationship: RO:0000057 CL:0000738 ! has participant leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>

[Term]
id: GO:0007162
name: negative regulation of cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "cell adhesion receptor inhibitor activity" RELATED []
synonym: "down regulation of cell adhesion" EXACT []
synonym: "down-regulation of cell adhesion" EXACT []
synonym: "downregulation of cell adhesion" EXACT []
synonym: "inhibition of cell adhesion" NARROW []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007155 ! negatively regulates cell adhesion
relationship: RO:0002212 GO:0007155 ! negatively regulates cell adhesion

[Term]
id: GO:0007163
name: establishment or maintenance of cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cell polarity" RELATED [GOC:mah, GOC:vw]
synonym: "establishment and/or maintenance of cell polarity" RELATED []
synonym: "establishment and/or maintenance of cell polarization" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
alt_id: GO:0023014
alt_id: GO:0023015
alt_id: GO:0023016
alt_id: GO:0023033
alt_id: GO:0023045
def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "signaling cascade" NARROW []
synonym: "signaling pathway" RELATED []
synonym: "signalling cascade" NARROW []
synonym: "signalling pathway" RELATED []
xref: Reactome:R-HSA-212718 "EGFR interacts with phospholipase C-gamma"
xref: Wikipedia:Signal_transduction
is_a: GO:0009987 ! cellular process
is_a: GO:0050794 ! regulation of cellular process
relationship: BFO:0000050 GO:0007154 ! part of cell communication
relationship: BFO:0000050 GO:0023052 ! part of signaling
relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus

[Term]
id: GO:0007166
name: cell surface receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]
subset: goslim_drosophila
synonym: "cell surface receptor linked signal transduction" EXACT []
synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf]
synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah]
xref: Reactome:R-HSA-73887 "Death Receptor Signaling"
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0007186
name: G protein-coupled receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
subset: goslim_drosophila
synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW []
synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah]
synonym: "G protein coupled receptor protein signaling pathway" EXACT []
synonym: "G protein coupled receptor protein signalling pathway" EXACT []
synonym: "G-protein coupled receptor protein signal transduction" EXACT []
synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf]
synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf]
synonym: "G-protein coupled receptor signalling pathway" EXACT []
synonym: "G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "GPCR signaling pathway" EXACT []
synonym: "GPCR signalling pathway" EXACT []
xref: Reactome:R-HSA-373076 "Class A/1 (Rhodopsin-like receptors)"
xref: Reactome:R-HSA-388396 "GPCR downstream signalling"
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002224 GO:0004930 ! starts with G protein-coupled receptor activity
relationship: RO:0002224 GO:0004930 ! starts with G protein-coupled receptor activity

[Term]
id: GO:0007213
name: G protein-coupled acetylcholine receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]
synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT []
synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT []
synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0095500 ! acetylcholine receptor signaling pathway
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002224 GO:0016907 ! starts with G protein-coupled acetylcholine receptor activity
relationship: RO:0002224 GO:0016907 ! starts with G protein-coupled acetylcholine receptor activity

[Term]
id: GO:0007214
name: gamma-aminobutyric acid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell." [GOC:mah]
synonym: "4-aminobutanoate signaling pathway" EXACT []
synonym: "4-aminobutanoate signalling pathway" EXACT []
synonym: "4-aminobutyrate signaling pathway" EXACT []
synonym: "4-aminobutyrate signalling pathway" EXACT []
synonym: "GABA signaling pathway" EXACT []
synonym: "GABA signalling pathway" EXACT []
synonym: "gamma-aminobutyric acid signalling pathway" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002224 GO:0016917 ! starts with GABA receptor activity
relationship: RO:0002224 GO:0016917 ! starts with GABA receptor activity

[Term]
id: GO:0007215
name: glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252]
synonym: "glutamate signaling pathway" EXACT [GOC:bf]
synonym: "glutamate signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002224 GO:0008066 ! starts with glutamate receptor activity
relationship: RO:0002224 GO:0008066 ! starts with glutamate receptor activity

[Term]
id: GO:0007216
name: G protein-coupled glutamate receptor signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252]
synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT []
synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf]
synonym: "metabotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
is_a: GO:0007215 ! glutamate receptor signaling pathway
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002224 GO:0098988 ! starts with G protein-coupled glutamate receptor activity
relationship: RO:0002224 GO:0098988 ! starts with G protein-coupled glutamate receptor activity

[Term]
id: GO:0007218
name: neuropeptide signaling pathway
namespace: biological_process
def: "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]
synonym: "neuropeptide signalling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway

[Term]
id: GO:0007267
name: cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]
subset: goslim_chembl
subset: goslim_plant
synonym: "cell-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling

[Term]
id: GO:0007268
name: chemical synaptic transmission
namespace: biological_process
def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]
subset: goslim_synapse
synonym: "neurotransmission" RELATED [GOC:dph]
synonym: "signal transmission across a synapse" BROAD []
synonym: "synaptic transmission" BROAD []
xref: Reactome:R-HSA-112316 "Neuronal System"
xref: Reactome:R-HSA-442720 "CREB1 phosphorylation through the activation of Adenylate Cyclase"
xref: Reactome:R-HSA-442729 "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"
xref: Reactome:R-HSA-442742 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"
xref: Reactome:R-HSA-451307 "Activation of Na-permeable kainate receptors"
xref: Reactome:R-HSA-451308 "Activation of Ca-permeable Kainate Receptor"
xref: Reactome:R-HSA-9619229 "Activation of RAC1 downstream of NMDARs"
xref: Reactome:R-HSA-9619483 "Activation of AMPK downstream of NMDARs"
xref: Reactome:R-HSA-9620244 "Long-term potentiation"
xref: Wikipedia:Neurotransmission
is_a: GO:0098916 ! anterograde trans-synaptic signaling
relationship: RO:0000057 GO:0045202 ! has participant synapse

[Term]
id: GO:0007269
name: neurotransmitter secretion
namespace: biological_process
def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph]
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
xref: Reactome:R-HSA-112310 "Neurotransmitter release cycle"
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
relationship: RO:0002338 GO:0098793 ! has target start location presynapse
relationship: RO:0002339 GO:0043083 ! has target end location synaptic cleft

[Term]
id: GO:0007271
name: synaptic transmission, cholinergic
namespace: biological_process
def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic]
synonym: "cholinergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission
relationship: RO:0000057 CHEBI:15355 ! has participant

[Term]
id: GO:0007272
name: ensheathment of neurons
namespace: biological_process
def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "ionic insulation of neurons by glial cells" RELATED []
is_a: GO:0009987 ! cellular process
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0000057 CL:0000125 ! has participant glial cell
relationship: RO:0000057 CL:0000540 ! has participant neuron

[Term]
id: GO:0007275
name: multicellular organism development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
comment: Note that this term was 'developmental process'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism
relationship: RO:0002295 UBERON:0000468 ! results in developmental progression of multicellular organism

[Term]
id: GO:0007276
name: gamete generation
namespace: biological_process
def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]
synonym: "gametogenesis" RELATED []
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction

[Term]
id: GO:0007281
name: germ cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
synonym: "gametogenesis" NARROW []
synonym: "germ-cell development" EXACT []
synonym: "primordial germ cell development" NARROW []
xref: Reactome:R-HSA-9827857 "Specification of primordial germ cells"
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000586 ! results in development of germ cell
relationship: BFO:0000050 GO:0007276 ! part of gamete generation
relationship: RO:0002296 CL:0000586 ! results in development of germ cell

[Term]
id: GO:0007292
name: female gamete generation
namespace: biological_process
def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0007293
name: germarium-derived egg chamber formation
namespace: biological_process
def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: BFO:0000050 GO:0048477 ! part of oogenesis
relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda

[Term]
id: GO:0007308
name: oocyte construction
namespace: biological_process
def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]
synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002297 CL:0000023 ! results in formation of oocyte
relationship: BFO:0000050 GO:0048599 ! part of oocyte development
relationship: RO:0002297 CL:0000023 ! results in formation of oocyte

[Term]
id: GO:0007338
name: single fertilization
namespace: biological_process
def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]
synonym: "zygote biosynthesis" RELATED []
synonym: "zygote formation" RELATED []
xref: Reactome:R-HSA-1187000 "Fertilization"
is_a: GO:0009566 ! fertilization
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0007343
name: egg activation
namespace: biological_process
def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
xref: Wikipedia:Egg_activation
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000025 ! has primary input egg cell
relationship: BFO:0000050 GO:0007338 ! part of single fertilization
relationship: RO:0004009 CL:0000025 ! has primary input egg cell

[Term]
id: GO:0007346
name: regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "mitotic cell cycle modulation" EXACT []
synonym: "mitotic cell cycle regulation" EXACT []
synonym: "mitotic cell cycle regulator" RELATED []
synonym: "modulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
xref: Reactome:R-HSA-2465910 "MASTL Facilitates Mitotic Progression"
xref: Reactome:R-HSA-68911 "G2 Phase"
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000278 ! regulates mitotic cell cycle
relationship: RO:0002211 GO:0000278 ! regulates mitotic cell cycle

[Term]
id: GO:0007350
name: blastoderm segmentation
namespace: biological_process
def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
is_a: GO:0035282 ! segmentation

[Term]
id: GO:0007369
name: gastrulation
namespace: biological_process
def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
subset: goslim_drosophila
xref: Reactome:R-HSA-9758941 "Gastrulation"
xref: Wikipedia:Gastrulation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: BFO:0000051 GO:0001705 ! has part ectoderm formation
relationship: BFO:0000051 GO:0001706 ! has part endoderm formation
relationship: BFO:0000051 GO:0001707 ! has part mesoderm formation

[Term]
id: GO:0007389
name: pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
subset: goslim_drosophila
synonym: "pattern biosynthesis" RELATED []
synonym: "pattern formation" RELATED []
is_a: GO:0032501 ! multicellular organismal process
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development

[Term]
id: GO:0007398
name: ectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000924 ! results in development of ectoderm
relationship: RO:0002296 UBERON:0000924 ! results in development of ectoderm

[Term]
id: GO:0007399
name: nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
subset: goslim_drosophila
synonym: "pan-neural process" RELATED []
xref: Reactome:R-HSA-9675108 "Nervous system development"
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001016 ! results in development of nervous system
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 UBERON:0001016 ! results in development of nervous system

[Term]
id: GO:0007405
name: neuroblast proliferation
namespace: biological_process
def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata)
relationship: BFO:0000050 GO:0048699 ! part of generation of neurons
relationship: RO:0012003 CL:0000031 ! acts on population of neuroblast (sensu Vertebrata)

[Term]
id: GO:0007406
name: negative regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
synonym: "down regulation of neuroblast proliferation" EXACT []
synonym: "down-regulation of neuroblast proliferation" EXACT []
synonym: "downregulation of neuroblast proliferation" EXACT []
synonym: "inhibition of neuroblast proliferation" NARROW []
synonym: "suppression of neuroblast proliferation" EXACT []
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation
relationship: RO:0002212 GO:0007405 ! negatively regulates neuroblast proliferation

[Term]
id: GO:0007407
name: neuroblast activation
namespace: biological_process
def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata)
relationship: BFO:0000050 GO:0048699 ! part of generation of neurons
relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata)

[Term]
id: GO:0007409
name: axonogenesis
namespace: biological_process
def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon).
synonym: "axon growth" NARROW []
synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308]
is_a: GO:0048812 ! neuron projection morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 GO:0030424 ! results in morphogenesis of axon
relationship: BFO:0000050 GO:0048667 ! part of cell morphogenesis involved in neuron differentiation
relationship: BFO:0000050 GO:0061564 ! part of axon development
relationship: RO:0002298 GO:0030424 ! results in morphogenesis of axon

[Term]
id: GO:0007416
name: synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]
subset: goslim_synapse
synonym: "synapse biogenesis" EXACT [GOC:mah]
synonym: "synaptogenesis" EXACT [GOC:mah]
xref: Wikipedia:Synaptogenesis
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0050808 ! synapse organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002588 GO:0045202 ! results in assembly of synapse
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002588 GO:0045202 ! results in assembly of synapse

[Term]
id: GO:0007417
name: central nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
synonym: "CNS development" EXACT []
xref: Wikipedia:Neural_development
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001017 ! results in development of central nervous system
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria
relationship: RO:0002296 UBERON:0001017 ! results in development of central nervous system

[Term]
id: GO:0007418
name: ventral midline development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0009571 ! results in development of ventral midline
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002296 UBERON:0009571 ! results in development of ventral midline

[Term]
id: GO:0007420
name: brain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000955 ! results in development of brain
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: BFO:0000050 GO:0060322 ! part of head development
relationship: RO:0002296 UBERON:0000955 ! results in development of brain

[Term]
id: GO:0007422
name: peripheral nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002296 UBERON:0000010 ! results in development of peripheral nervous system

[Term]
id: GO:0007423
name: sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
subset: goslim_drosophila
synonym: "sense organ development" EXACT [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000020 ! results in development of sense organ
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 UBERON:0000020 ! results in development of sense organ

[Term]
id: GO:0007439
name: ectodermal digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators]
synonym: "ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002297 UBERON:0004906 ! results in formation of ectodermal part of digestive tract
relationship: BFO:0000050 GO:0048565 ! part of digestive tract development
relationship: RO:0002297 UBERON:0004906 ! results in formation of ectodermal part of digestive tract

[Term]
id: GO:0007440
name: foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut
relationship: BFO:0000050 GO:0048546 ! part of digestive tract morphogenesis
relationship: RO:0002298 UBERON:0001041 ! results in morphogenesis of foregut

[Term]
id: GO:0007492
name: endoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000925 ! results in development of endoderm
relationship: RO:0002296 UBERON:0000925 ! results in development of endoderm

[Term]
id: GO:0007498
name: mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
subset: goslim_drosophila
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000926 ! results in development of mesoderm
relationship: RO:0002296 UBERON:0000926 ! results in development of mesoderm

[Term]
id: GO:0007506
name: gonadal mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme
relationship: BFO:0000050 GO:0008406 ! part of gonad development
relationship: RO:0002296 UBERON:0003855 ! results in development of gonad mesenchyme

[Term]
id: GO:0007507
name: heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
synonym: "cardiac development" RELATED []
synonym: "dorsal vessel development" NARROW []
xref: Wikipedia:Heart_development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ
relationship: BFO:0000050 GO:0072359 ! part of circulatory system development
relationship: RO:0002296 UBERON:0007100 ! results in development of primary circulatory organ

[Term]
id: GO:0007517
name: muscle organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
is_a: GO:0048513 ! animal organ development
is_a: GO:0061061 ! muscle structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001630 ! results in development of muscle organ
relationship: RO:0002296 UBERON:0001630 ! results in development of muscle organ

[Term]
id: GO:0007519
name: skeletal muscle tissue development
namespace: biological_process
def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
synonym: "myogenesis" RELATED []
is_a: GO:0014706 ! striated muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue
relationship: BFO:0000050 GO:0060538 ! part of skeletal muscle organ development
relationship: RO:0002296 UBERON:0001134 ! results in development of skeletal muscle tissue

[Term]
id: GO:0007528
name: neuromuscular junction development
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
synonym: "neuromuscular junction organization" EXACT []
synonym: "neuromuscular junction stability" RELATED [GOC:pr]
synonym: "NMJ stability" RELATED [GOC:pr]
is_a: GO:0050808 ! synapse organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction
relationship: RO:0002592 GO:0031594 ! results in organization of neuromuscular junction

[Term]
id: GO:0007530
name: sex determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732]
xref: Wikipedia:Sex-determination_system
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007548
name: sex differentiation
namespace: biological_process
def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai]
xref: Wikipedia:Sexual_differentiation
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007565
name: female pregnancy
namespace: biological_process
def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825]
subset: goslim_chembl
synonym: "carrying of young" RELATED []
synonym: "gestation" EXACT []
xref: Wikipedia:Gestation
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia

[Term]
id: GO:0007566
name: embryo implantation
namespace: biological_process
def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, PMID:10882512]
synonym: "blastocyst implantation" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development
relationship: BFO:0000050 GO:0007565 ! part of female pregnancy

[Term]
id: GO:0007585
name: respiratory gaseous exchange by respiratory system
namespace: biological_process
def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732]
subset: goslim_chembl
synonym: "breathing" BROAD []
synonym: "respiration" BROAD []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007586
name: digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
xref: Reactome:R-HSA-8935690 "Digestion"
xref: Wikipedia:Digestion
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007589
name: body fluid secretion
namespace: biological_process
def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0046903 ! secretion
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007600
name: sensory perception
namespace: biological_process
def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]
subset: goslim_drosophila
xref: Reactome:R-HSA-9709957 "Sensory Perception"
xref: Wikipedia:Perception
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0007601
name: visual perception
namespace: biological_process
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
synonym: "sense of sight" EXACT []
synonym: "sensory visual perception" EXACT []
synonym: "vision" EXACT []
xref: Wikipedia:Visual_perception
is_a: GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0007605
name: sensory perception of sound
namespace: biological_process
def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
synonym: "hearing" EXACT []
synonym: "perception of sound" EXACT []
xref: Reactome:R-HSA-9659379 "Sensory processing of sound"
xref: Wikipedia:Hearing_(sense)
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0007606
name: sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemosensory perception" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0007610
name: behavior
namespace: biological_process
def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
synonym: "behavioral response to stimulus" EXACT []
synonym: "behaviour" EXACT []
synonym: "behavioural response to stimulus" EXACT []
synonym: "single-organism behavior" RELATED []
xref: Wikipedia:Behavior
is_a: GO:0032501 ! multicellular organismal process
disjoint_from: GO:0032502 ! developmental process
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
relationship: RO:0002608 UBERON:0001016 ! process has causal agent nervous system
creation_date: 2012-09-20T14:06:08Z

[Term]
id: GO:0007611
name: learning or memory
namespace: biological_process
def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]
is_a: GO:0007610 ! behavior
is_a: GO:0050890 ! cognition

[Term]
id: GO:0007613
name: memory
namespace: biological_process
def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089]
xref: Wikipedia:Memory
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0008015
name: blood circulation
namespace: biological_process
def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]
subset: goslim_pir
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0008016
name: regulation of heart contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of cardiac contraction" EXACT []
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060047 ! regulates heart contraction
relationship: RO:0002211 GO:0060047 ! regulates heart contraction

[Term]
id: GO:0008017
name: microtubule binding
namespace: molecular_function
def: "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]
synonym: "microtubule severing activity" RELATED []
synonym: "microtubule/chromatin interaction" RELATED []
xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs"
is_a: GO:0015631 ! tubulin binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0005874 ! has primary input microtubule
relationship: RO:0004009 GO:0005874 ! has primary input microtubule

[Term]
id: GO:0008028
name: monocarboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]
synonym: "monocarboxylate carrier" NARROW []
synonym: "prostaglandin/thromboxane transporter activity" NARROW []
xref: Reactome:R-HSA-429749 "SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:25384 ! has primary input monocarboxylic acid
relationship: BFO:0000050 GO:0015718 ! part of monocarboxylic acid transport
relationship: RO:0004009 CHEBI:25384 ! has primary input monocarboxylic acid

[Term]
id: GO:0008053
name: mitochondrial fusion
namespace: biological_process
def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]
synonym: "mitochondrial membrane fusion" RELATED []
synonym: "mitochondrion fusion" EXACT []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0048284 ! organelle fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0005739 ! results in fusion of mitochondrion
relationship: RO:0012008 GO:0005739 ! results in fusion of mitochondrion
creation_date: 2015-01-21T06:58:18Z

[Term]
id: GO:0008061
name: chitin binding
namespace: molecular_function
def: "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: goslim_drosophila
is_a: GO:0097367 ! carbohydrate derivative binding

[Term]
id: GO:0008066
name: glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]
is_a: GO:0004888 ! transmembrane signaling receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:14321 ! has primary input
relationship: BFO:0000051 GO:0016595 ! has part glutamate binding
relationship: RO:0004009 CHEBI:14321 ! has primary input

[Term]
id: GO:0008078
name: mesodermal cell migration
namespace: biological_process
def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]
synonym: "mesoderm cell migration" EXACT []
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000222 ! results in movement of mesodermal cell
relationship: RO:0002565 CL:0000222 ! results in movement of mesodermal cell

[Term]
id: GO:0008088
name: axo-dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" NARROW []
synonym: "axonal transport" NARROW []
synonym: "axoplasmic transport" NARROW []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0010970 ! transport along microtubule
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:0043005 ! occurs in neuron projection
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0008089
name: anterograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" EXACT []
is_a: GO:0098930 ! axonal transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
relationship: RO:0002339 GO:0098793 ! has target end location presynapse

[Term]
id: GO:0008090
name: retrograde axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" EXACT []
is_a: GO:0098930 ! axonal transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
relationship: RO:0002338 GO:0098793 ! has target start location presynapse

[Term]
id: GO:0008092
name: cytoskeletal protein binding
namespace: molecular_function
def: "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_prokaryote
subset: goslim_yeast
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008104
name: intracellular protein localization
namespace: biological_process
alt_id: GO:0008105
alt_id: GO:0016249
alt_id: GO:0034613
def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
subset: goslim_drosophila
synonym: "asymmetric protein localisation" RELATED [GOC:mah]
synonym: "asymmetric protein localization" RELATED []
synonym: "cellular protein localisation" EXACT [GOC:mah]
synonym: "cellular protein localization" EXACT []
synonym: "channel localizer activity" NARROW [GOC:mah]
synonym: "establishment and maintenance of asymmetric protein localization" RELATED []
synonym: "establishment and maintenance of protein localization" RELATED []
synonym: "protein localisation" EXACT [GOC:mah]
synonym: "protein localization" BROAD []
xref: Reactome:R-HSA-9609507 "Protein localization"
is_a: GO:0070727 ! cellular macromolecule localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0008134
name: transcription factor binding
namespace: molecular_function
def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]
comment: Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "TF binding" EXACT []
synonym: "transcription regulator binding" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
alt_id: GO:0044699
def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
synonym: "biological process" EXACT []
synonym: "physiological process" EXACT []
synonym: "single organism process" RELATED []
synonym: "single-organism process" RELATED []
xref: Wikipedia:Biological_process
is_a: BFO:0000015 ! process
created_by: jl
creation_date: 2012-09-19T15:05:24Z

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
alt_id: GO:0044236
alt_id: GO:0044710
def: "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote_ribbon
synonym: "metabolism" EXACT []
xref: Reactome:R-HSA-1430728 "Metabolism"
xref: Wikipedia:Metabolism
is_a: GO:0009987 ! cellular process
disjoint_from: GO:0044848 ! biological phase
disjoint_from: GO:0051179 ! localization
created_by: jl
creation_date: 2012-10-17T15:46:40Z

[Term]
id: GO:0008188
name: neuropeptide receptor activity
namespace: molecular_function
def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G protein-coupled peptide receptor activity
relationship: BFO:0000050 GO:0007218 ! part of neuropeptide signaling pathway
relationship: BFO:0000051 GO:0042923 ! has part neuropeptide binding

[Term]
id: GO:0008202
name: steroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]
synonym: "steroid metabolism" EXACT []
xref: Reactome:R-HSA-8957322 "Metabolism of steroids"
xref: Wikipedia:Steroid_metabolism
is_a: GO:0006629 ! lipid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:35341 ! has primary input or output steroid
relationship: RO:0004007 CHEBI:35341 ! has primary input or output steroid

[Term]
id: GO:0008217
name: regulation of blood pressure
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure homeostasis" RELATED []
synonym: "blood pressure regulation" EXACT []
synonym: "control of blood pressure" RELATED []
xref: Wikipedia:Blood_pressure#Regulation
is_a: GO:0065008 ! regulation of biological quality
relationship: BFO:0000050 GO:0008015 ! part of blood circulation

[Term]
id: GO:0008219
name: cell death
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]
comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.
subset: gocheck_do_not_annotate
synonym: "accidental cell death" RELATED []
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008227
name: G protein-coupled amine receptor activity
namespace: molecular_function
def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "biogenic amine receptor" NARROW []
synonym: "G-protein coupled amine receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
intersection_of: GO:0004930 ! G protein-coupled receptor activity
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
alt_id: GO:0070010
alt_id: GO:0070011
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [EC:3.4.-.-, GOC:jl]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptidase activity, acting on D-amino acid peptides" NARROW []
synonym: "peptidase activity, acting on L-amino acid peptides" NARROW []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" NARROW []
xref: EC:3.4.-.-
xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6"
xref: Reactome:R-HSA-3000243 "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl"
xref: Reactome:R-HSA-3000263 "TCN2:RCbl is degraded to release RCbl"
xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA"
xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs"
xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion"
xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT"
xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB"
xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)"
xref: Reactome:R-HSA-5655483 "USP1 autocleavage"
xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB"
xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC"
xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)"
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0008277
name: regulation of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]
synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of GPCR protein signaling pathway" EXACT []
synonym: "regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007186 ! regulates G protein-coupled receptor signaling pathway
relationship: RO:0002211 GO:0007186 ! regulates G protein-coupled receptor signaling pathway

[Term]
id: GO:0008283
name: cell population proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "cell proliferation" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008284
name: positive regulation of cell population proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "activation of cell proliferation" NARROW []
synonym: "positive regulation of cell proliferation" RELATED []
synonym: "stimulation of cell proliferation" NARROW []
synonym: "up regulation of cell proliferation" EXACT []
synonym: "up-regulation of cell proliferation" EXACT []
synonym: "upregulation of cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008283 ! positively regulates cell population proliferation
relationship: RO:0002213 GO:0008283 ! positively regulates cell population proliferation

[Term]
id: GO:0008285
name: negative regulation of cell population proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "down regulation of cell proliferation" EXACT []
synonym: "down-regulation of cell proliferation" EXACT []
synonym: "downregulation of cell proliferation" EXACT []
synonym: "inhibition of cell proliferation" NARROW []
synonym: "negative regulation of cell proliferation" RELATED []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation
relationship: RO:0002212 GO:0008283 ! negatively regulates cell population proliferation

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Binding to a lipid." [GOC:ai]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0008291
name: acetylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:15355 ! has primary input or output
relationship: RO:0004007 CHEBI:15355 ! has primary input or output

[Term]
id: GO:0008292
name: acetylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine anabolism" EXACT []
synonym: "acetylcholine biosynthesis" EXACT []
synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:15355 ! has primary output
relationship: RO:0004008 CHEBI:15355 ! has primary output

[Term]
id: GO:0008299
name: isoprenoid biosynthetic process
namespace: biological_process
alt_id: GO:0009241
def: "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]
synonym: "isoprenoid anabolism" EXACT []
synonym: "isoprenoid biosynthesis" EXACT []
synonym: "isoprenoid formation" EXACT []
synonym: "isoprenoid synthesis" EXACT []
synonym: "polyisoprenoid anabolism" NARROW []
synonym: "polyisoprenoid biosynthesis" NARROW []
synonym: "polyisoprenoid biosynthetic process" NARROW []
synonym: "polyisoprenoid formation" NARROW []
synonym: "polyisoprenoid synthesis" NARROW []
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
xref: MetaCyc:POLYISOPRENSYN-PWY
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0008320
name: protein transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl]
synonym: "protein channel activity" RELATED []
xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space"
xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix"
xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex"
xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane"
xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria"
xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol"
xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen"
xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol"
xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane"
xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol"
xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation"
xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation"
xref: Reactome:R-HSA-9760705 "GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space"
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:0140318 ! protein transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: BFO:0000050 GO:0071806 ! part of protein transmembrane transport

[Term]
id: GO:0008347
name: glial cell migration
namespace: biological_process
def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
synonym: "glia cell migration" EXACT []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000125 ! results in movement of glial cell
relationship: BFO:0000050 GO:0042063 ! part of gliogenesis
relationship: RO:0002565 CL:0000125 ! results in movement of glial cell

[Term]
id: GO:0008354
name: germ cell migration
namespace: biological_process
def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
synonym: "germ-cell migration" EXACT []
synonym: "pole cell migration" NARROW []
synonym: "primordial germ cell migration" RELATED []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000586 ! results in movement of germ cell
relationship: BFO:0000050 GO:0007276 ! part of gamete generation
relationship: RO:0002565 CL:0000586 ! results in movement of germ cell

[Term]
id: GO:0008356
name: asymmetric cell division
namespace: biological_process
def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
synonym: "asymmetric cytokinesis" RELATED []
synonym: "asymmetrical cell division" EXACT []
synonym: "asymmetrical cytokinesis" RELATED []
xref: Wikipedia:Asymmetric_cell_division
is_a: GO:0051301 ! cell division

[Term]
id: GO:0008366
name: axon ensheathment
namespace: biological_process
def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
synonym: "cellular axon ensheathment" EXACT []
synonym: "cellular nerve ensheathment" RELATED []
synonym: "nerve ensheathment" RELATED []
is_a: GO:0007272 ! ensheathment of neurons
relationship: RO:0000057 GO:0030424 ! has participant axon

[Term]
id: GO:0008406
name: gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
synonym: "gonadogenesis" EXACT [GOC:cjm]
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000991 ! results in development of gonad
relationship: BFO:0000050 GO:0045137 ! part of development of primary sexual characteristics
relationship: RO:0002296 UBERON:0000991 ! results in development of gonad

[Term]
id: GO:0008502
name: melatonin receptor activity
namespace: molecular_function
def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732]
is_a: GO:0004930 ! G protein-coupled receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:16796 ! has primary input
relationship: RO:0004009 CHEBI:16796 ! has primary input

[Term]
id: GO:0008504
name: monoamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah]
xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles"
xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol"
xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles"
xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse"
xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol"
is_a: GO:0022804 ! active transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:63534 ! has primary input
relationship: BFO:0000050 GO:0015844 ! part of monoamine transport
relationship: RO:0004009 CHEBI:63534 ! has primary input

[Term]
id: GO:0008528
name: G protein-coupled peptide receptor activity
namespace: molecular_function
def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]
synonym: "G protein coupled peptide receptor activity" EXACT []
synonym: "G-protein coupled peptide receptor activity" EXACT []
synonym: "peptide receptor activity, G protein coupled" EXACT []
synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0001653 ! peptide receptor activity
is_a: GO:0004930 ! G protein-coupled receptor activity

[Term]
id: GO:0008544
name: epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0008585
name: female gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
synonym: "ovarian development" RELATED [GOC:sl]
synonym: "ovary development" RELATED [GOC:sl]
is_a: GO:0008406 ! gonad development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000992 ! results in development of ovary
relationship: BFO:0000050 GO:0046545 ! part of development of primary female sexual characteristics
relationship: RO:0002296 UBERON:0000992 ! results in development of ovary

[Term]
id: GO:0008594
name: photoreceptor cell morphogenesis
namespace: biological_process
def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
synonym: "photoreceptor development" RELATED []
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell
relationship: BFO:0000050 GO:0042461 ! part of photoreceptor cell development
relationship: RO:0002298 CL:0000210 ! results in morphogenesis of photoreceptor cell

[Term]
id: GO:0008610
name: lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
synonym: "lipid anabolism" EXACT []
synonym: "lipid biosynthesis" EXACT []
synonym: "lipid formation" EXACT []
synonym: "lipid synthesis" EXACT []
synonym: "lipogenesis" EXACT [GOC:sl]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18059 ! has primary output lipid
relationship: RO:0004008 CHEBI:18059 ! has primary output lipid

[Term]
id: GO:0008641
name: ubiquitin-like modifier activating enzyme activity
namespace: molecular_function
alt_id: GO:0008642
def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "small protein activating enzyme activity" NARROW []
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds
is_a: GO:0140096 ! catalytic activity, acting on a protein
is_a: GO:0140657 ! ATP-dependent activity

[Term]
id: GO:0008643
name: carbohydrate transport
namespace: biological_process
def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
synonym: "sugar transport" NARROW []
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate

[Term]
id: GO:0008652
name: amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]
synonym: "amino acid anabolism" EXACT []
synonym: "amino acid biosynthesis" EXACT []
synonym: "amino acid formation" EXACT []
synonym: "amino acid synthesis" EXACT []
synonym: "cellular amino acid biosynthetic process" EXACT []
xref: Wikipedia:Amino_acid_synthesis
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:35238 ! has primary output amino-acid zwitterion
relationship: RO:0004008 CHEBI:35238 ! has primary output amino-acid zwitterion

[Term]
id: GO:0009056
name: catabolic process
namespace: biological_process
alt_id: GO:0044243
alt_id: GO:0044712
def: "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "breakdown of chemical" EXACT []
synonym: "breakdown of molecule" EXACT []
synonym: "breakdown of substance" EXACT []
synonym: "catabolism" EXACT []
synonym: "cellular breakdown" EXACT []
synonym: "cellular catabolism" EXACT []
synonym: "cellular degradation" EXACT []
synonym: "degradation" EXACT []
xref: Wikipedia:Catabolism
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2012-10-17T15:52:35Z

[Term]
id: GO:0009057
name: macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule catabolic process" RELATED []
synonym: "cellular macromolecule catabolism" RELATED []
synonym: "cellular macromolecule degradation" RELATED []
synonym: "macromolecule breakdown" EXACT []
synonym: "macromolecule catabolism" EXACT []
synonym: "macromolecule degradation" EXACT []
synonym: "multicellular organismal macromolecule catabolic process" NARROW []
is_a: GO:0009056 ! catabolic process
is_a: GO:0043170 ! macromolecule metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule
relationship: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule

[Term]
id: GO:0009058
name: biosynthetic process
namespace: biological_process
alt_id: GO:0044274
alt_id: GO:0044711
def: "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "anabolism" EXACT []
synonym: "biosynthesis" EXACT []
synonym: "formation" BROAD []
synonym: "multicellular organismal biosynthetic process" NARROW []
synonym: "single-organism biosynthetic process" RELATED []
synonym: "synthesis" EXACT []
xref: Wikipedia:Anabolism
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2012-10-17T15:52:18Z

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0043284
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule anabolism" EXACT []
synonym: "macromolecule biosynthesis" EXACT []
synonym: "macromolecule formation" EXACT []
synonym: "macromolecule synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0043170 ! macromolecule metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33694 ! has primary output biomacromolecule
relationship: RO:0004008 CHEBI:33694 ! has primary output biomacromolecule

[Term]
id: GO:0009063
name: amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]
synonym: "amino acid breakdown" EXACT []
synonym: "amino acid catabolism" EXACT []
synonym: "amino acid degradation" EXACT []
synonym: "cellular amino acid catabolic process" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0009064
name: glutamine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
synonym: "glutamine family amino acid metabolism" EXACT []
xref: Reactome:R-HSA-8964539 "Glutamate and glutamine metabolism"
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:24318 ! has primary input or output glutamine family amino acid
relationship: RO:0004007 CHEBI:24318 ! has primary input or output glutamine family amino acid

[Term]
id: GO:0009067
name: aspartate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai, MetaCyc:PWY0-781]
synonym: "aspartate family amino acid anabolism" EXACT []
synonym: "aspartate family amino acid biosynthesis" EXACT []
synonym: "aspartate family amino acid formation" EXACT []
synonym: "aspartate family amino acid synthesis" EXACT []
xref: MetaCyc:PWY0-781
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process

[Term]
id: GO:0009070
name: serine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
synonym: "serine family amino acid anabolism" EXACT []
synonym: "serine family amino acid biosynthesis" EXACT []
synonym: "serine family amino acid formation" EXACT []
synonym: "serine family amino acid synthesis" EXACT []
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26650 ! has primary output
relationship: RO:0004008 CHEBI:26650 ! has primary output

[Term]
id: GO:0009084
name: glutamine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
synonym: "glutamine family amino acid anabolism" EXACT []
synonym: "glutamine family amino acid biosynthesis" EXACT []
synonym: "glutamine family amino acid formation" EXACT []
synonym: "glutamine family amino acid synthesis" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0170034 ! L-amino acid biosynthetic process
is_a: GO:0170038 ! proteinogenic amino acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:24318 ! has primary output glutamine family amino acid
relationship: RO:0004008 CHEBI:24318 ! has primary output glutamine family amino acid

[Term]
id: GO:0009085
name: L-lysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-lysine, 2,6-diaminohexanoic acid." [GOC:go_curators, MetaCyc:LYSINE-SYN]
synonym: "lysine anabolism" EXACT []
synonym: "lysine biosynthesis" EXACT []
synonym: "lysine formation" EXACT []
synonym: "lysine synthesis" EXACT []
xref: MetaCyc:LYSINE-SYN
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009100
name: glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
subset: goslim_drosophila
synonym: "glycoprotein metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:17089 ! has primary input or output
relationship: RO:0004007 CHEBI:17089 ! has primary input or output

[Term]
id: GO:0009101
name: glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [PMID:35536965]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "glycoprotein anabolism" EXACT []
synonym: "glycoprotein biosynthesis" EXACT []
synonym: "glycoprotein formation" EXACT []
synonym: "glycoprotein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:17089 ! has primary output
relationship: RO:0004008 CHEBI:17089 ! has primary output

[Term]
id: GO:0009112
name: nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma]
synonym: "nucleobase metabolism" EXACT []
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase
relationship: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase

[Term]
id: GO:0009295
name: nucleoid
namespace: cellular_component
def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689]
xref: Wikipedia:Nucleoid
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0009306
name: protein secretion
namespace: biological_process
alt_id: GO:0045166
alt_id: GO:0045731
def: "The controlled release of proteins from a cell." [GOC:ai]
synonym: "glycoprotein secretion" NARROW []
synonym: "protein secretion during cell fate commitment" NARROW []
synonym: "protein secretion resulting in cell fate commitment" NARROW []
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0035592 ! establishment of protein localization to extracellular region
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0009308
name: amine metabolic process
namespace: biological_process
alt_id: GO:0044106
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
synonym: "amine metabolism" EXACT []
synonym: "cellular amine metabolic process" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:32952 ! has primary input or output amine
relationship: RO:0004007 CHEBI:32952 ! has primary input or output amine
created_by: jl
creation_date: 2009-07-15T11:55:44Z

[Term]
id: GO:0009309
name: amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
synonym: "amine anabolism" EXACT []
synonym: "amine biosynthesis" EXACT []
synonym: "amine formation" EXACT []
synonym: "amine synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009308 ! amine metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:32952 ! has primary output amine
relationship: RO:0004008 CHEBI:32952 ! has primary output amine

[Term]
id: GO:0009310
name: amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
synonym: "amine breakdown" EXACT []
synonym: "amine catabolism" EXACT []
synonym: "amine degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0009308 ! amine metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine

[Term]
id: GO:0009314
name: response to radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
synonym: "response to electromagnetic radiation stimulus" EXACT []
synonym: "response to radiation stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009403
name: toxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
subset: goslim_metagenomics
synonym: "toxin anabolism" EXACT []
synonym: "toxin biosynthesis" EXACT []
synonym: "toxin formation" EXACT []
synonym: "toxin synthesis" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process

[Term]
id: GO:0009404
name: toxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]
subset: goslim_pir
synonym: "toxin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009416
name: response to light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
subset: goslim_plant
is_a: GO:0009314 ! response to radiation
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:30212 ! has primary input
relationship: RO:0004009 CHEBI:30212 ! has primary input

[Term]
id: GO:0009448
name: gamma-aminobutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]
comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'.
synonym: "4-aminobutanoate metabolic process" EXACT []
synonym: "4-aminobutanoate metabolism" EXACT []
synonym: "4-aminobutyrate metabolic process" EXACT []
synonym: "4-aminobutyrate metabolism" EXACT []
synonym: "GABA metabolic process" EXACT []
synonym: "GABA metabolism" EXACT []
synonym: "gamma-aminobutyric acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:59888 ! has primary input or output
relationship: RO:0004007 CHEBI:59888 ! has primary input or output

[Term]
id: GO:0009449
name: gamma-aminobutyric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'.
synonym: "4-aminobutanoate biosynthesis" EXACT []
synonym: "4-aminobutanoate biosynthetic process" EXACT []
synonym: "4-aminobutyrate biosynthesis" EXACT []
synonym: "4-aminobutyrate biosynthetic process" EXACT []
synonym: "GABA biosynthesis" EXACT []
synonym: "GABA biosynthetic process" EXACT []
synonym: "gamma-aminobutyric acid anabolism" EXACT []
synonym: "gamma-aminobutyric acid biosynthesis" EXACT []
synonym: "gamma-aminobutyric acid formation" EXACT []
synonym: "gamma-aminobutyric acid synthesis" EXACT []
xref: Reactome:R-HSA-888568 "GABA synthesis"
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0170043 ! non-proteinogenic amino acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:59888 ! has primary output
relationship: RO:0004008 CHEBI:59888 ! has primary output

[Term]
id: GO:0009450
name: gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'.
synonym: "4-aminobutanoate catabolic process" EXACT []
synonym: "4-aminobutanoate catabolism" EXACT []
synonym: "4-aminobutyrate catabolic process" EXACT []
synonym: "4-aminobutyrate catabolism" EXACT []
synonym: "GABA catabolic process" EXACT []
synonym: "GABA catabolism" EXACT []
synonym: "gamma-aminobutyric acid breakdown" EXACT []
synonym: "gamma-aminobutyric acid catabolism" EXACT []
synonym: "gamma-aminobutyric acid degradation" EXACT []
xref: MetaCyc:4AMINOBUTMETAB-PWY
xref: Reactome:R-HSA-916853 "Degradation of GABA"
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0170044 ! non-proteinogenic amino acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:59888 ! has primary input
relationship: RO:0004009 CHEBI:59888 ! has primary input

[Term]
id: GO:0009507
name: chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208]
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Chloroplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009508
name: plastid chromosome
namespace: cellular_component
def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943088399]
is_a: GO:0005694 ! chromosome
intersection_of: GO:0005694 ! chromosome
intersection_of: BFO:0000050 GO:0009536 ! part of plastid
relationship: BFO:0000050 GO:0042646 ! part of plastid nucleoid

[Term]
id: GO:0009526
name: plastid envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy]
is_a: GO:0031967 ! organelle envelope
relationship: BFO:0000050 GO:0009536 ! part of plastid

[Term]
id: GO:0009527
name: plastid outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr]
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0042170 ! plastid membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0009536 ! bounding layer of plastid
relationship: RO:0002007 GO:0009536 ! bounding layer of plastid

[Term]
id: GO:0009532
name: plastid stroma
namespace: cellular_component
def: "The proteinaceous ground substance of plastids." [ISBN:0943088399]
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0009536 ! part of plastid

[Term]
id: GO:0009536
name: plastid
namespace: cellular_component
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Plastid
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0009547
name: plastid ribosome
namespace: cellular_component
def: "A ribosome contained within a plastid." [GOC:tair_curators]
is_a: GO:0000313 ! organellar ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: BFO:0000050 GO:0009536 ! part of plastid
relationship: BFO:0000050 GO:0009532 ! part of plastid stroma

[Term]
id: GO:0009566
name: fertilization
namespace: biological_process
def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]
synonym: "syngamy" EXACT []
xref: Wikipedia:Fertilisation
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0022414 ! reproductive process
intersection_of: RO:0002297 CL:0010017 ! results in formation of zygote
intersection_of: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus
relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction
relationship: RO:0002297 CL:0010017 ! results in formation of zygote
relationship: RO:0012008 GO:0043073 ! results in fusion of germ cell nucleus

[Term]
id: GO:0009570
name: chloroplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684]
is_a: GO:0009532 ! plastid stroma
relationship: BFO:0000050 GO:0009507 ! part of chloroplast

[Term]
id: GO:0009581
name: detection of external stimulus
namespace: biological_process
def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of external stimulus" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009582
name: detection of abiotic stimulus
namespace: biological_process
def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of abiotic stimulus" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009583
name: detection of light stimulus
namespace: biological_process
def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators]
synonym: "detection of light" EXACT []
synonym: "perception of light" RELATED []
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0009584
name: detection of visible light
namespace: biological_process
def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
synonym: "perception of visible light" RELATED []
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009593
name: detection of chemical stimulus
namespace: biological_process
def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "chemoperception" EXACT []
synonym: "chemoreception" RELATED []
synonym: "detection of chemical substance" EXACT []
synonym: "perception of chemical stimulus" RELATED []
synonym: "perception of chemical substance" RELATED []
is_a: GO:0051606 ! detection of stimulus
relationship: BFO:0000050 GO:0042221 ! part of response to chemical

[Term]
id: GO:0009605
name: response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_plant
synonym: "response to environmental stimulus" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009607
name: response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to biotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009620
name: response to fungus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
synonym: "response to fungi" EXACT []
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi
relationship: RO:0004009 NCBITaxon:4751 ! has primary input Fungi

[Term]
id: GO:0009626
name: plant-type hypersensitive response
namespace: biological_process
def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089]
comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider using 'effector-mediated activation of plant hypersensitive response by symbiont' ; GO:0080185.
synonym: "HR" BROAD []
synonym: "HR-PCD" EXACT []
synonym: "plant hypersensitive response" EXACT []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034050 ! symbiont-induced defense-related programmed cell death
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009628
name: response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to abiotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009653
name: anatomical structure morphogenesis
namespace: biological_process
def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
synonym: "anatomical structure organization" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "morphogenesis" EXACT []
xref: Wikipedia:Morphogenesis
is_a: GO:0032502 ! developmental process
disjoint_from: GO:0048856 ! anatomical structure development
disjoint_from: GO:0071695 ! anatomical structure maturation
relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development

[Term]
id: GO:0009657
name: plastid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah]
subset: goslim_pir
synonym: "plastid organisation" EXACT []
synonym: "plastid organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0009536 ! results in organization of plastid
relationship: RO:0002592 GO:0009536 ! results in organization of plastid

[Term]
id: GO:0009658
name: chloroplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid]
synonym: "chloroplast organisation" EXACT []
synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0009507 ! results in organization of chloroplast
relationship: RO:0002592 GO:0009507 ! results in organization of chloroplast

[Term]
id: GO:0009665
name: plastid inheritance
namespace: biological_process
def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah]
is_a: GO:0009657 ! plastid organization
is_a: GO:0048308 ! organelle inheritance
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: GOREL:0002003 GO:0009536 ! results in distribution of plastid
relationship: GOREL:0002003 GO:0009536 ! results in distribution of plastid

[Term]
id: GO:0009666
name: plastid outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid outer membrane organisation" EXACT []
synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0009527 ! results in organization of plastid outer membrane
relationship: RO:0002592 GO:0009527 ! results in organization of plastid outer membrane

[Term]
id: GO:0009668
name: plastid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid membrane organisation" EXACT []
synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0042170 ! results in organization of plastid membrane
relationship: BFO:0000050 GO:0009657 ! part of plastid organization
relationship: RO:0002592 GO:0042170 ! results in organization of plastid membrane

[Term]
id: GO:0009707
name: chloroplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb]
synonym: "chloroplast outer envelope" EXACT []
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0031969 ! chloroplast membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0009507 ! bounding layer of chloroplast
relationship: RO:0002007 GO:0009507 ! bounding layer of chloroplast

[Term]
id: GO:0009712
name: catechol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684]
synonym: "catechol metabolic process" RELATED []
synonym: "catechol metabolism" RELATED []
is_a: GO:0018958 ! phenol-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33566 ! has primary input or output
relationship: RO:0004007 CHEBI:33566 ! has primary input or output

[Term]
id: GO:0009713
name: catechol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
synonym: "catechol anabolism" RELATED []
synonym: "catechol biosynthesis" RELATED []
synonym: "catechol biosynthetic process" RELATED []
synonym: "catechol formation" RELATED []
synonym: "catechol synthesis" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33566 ! has primary output
relationship: RO:0004008 CHEBI:33566 ! has primary output

[Term]
id: GO:0009719
name: response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_plant
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009725
name: response to hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]
synonym: "growth regulator" RELATED []
synonym: "response to hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009743
name: response to carbohydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl]
synonym: "response to carbohydrate stimulus" EXACT [GOC:dos]
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate

[Term]
id: GO:0009755
name: hormone-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the detection of a hormone." [GOC:sm]
synonym: "hormone mediated signalling" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: BFO:0000050 GO:0032870 ! part of cellular response to hormone stimulus

[Term]
id: GO:0009786
name: regulation of asymmetric cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008356 ! regulates asymmetric cell division
relationship: RO:0002211 GO:0008356 ! regulates asymmetric cell division

[Term]
id: GO:0009790
name: embryo development
namespace: biological_process
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
synonym: "embryogenesis" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "embryonal development" EXACT []
xref: Reactome:R-HSA-5619507 "Activation of HOX genes during differentiation"
xref: Wikipedia:Embryogenesis
is_a: GO:0007275 ! multicellular organism development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000922 ! results in development of embryo
relationship: RO:0002296 UBERON:0000922 ! results in development of embryo

[Term]
id: GO:0009791
name: post-embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development

[Term]
id: GO:0009792
name: embryo development ending in birth or egg hatching
namespace: biological_process
def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0009790 ! embryo development
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0009847
name: spore germination
namespace: biological_process
alt_id: GO:0075005
def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr]
synonym: "spore germination on or near host" NARROW []
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0009880
name: embryonic pattern specification
namespace: biological_process
def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
synonym: "embryonic pattern biosynthesis" BROAD []
synonym: "embryonic pattern formation" BROAD []
synonym: "ventral/lateral system" RELATED []
is_a: GO:0007389 ! pattern specification process
relationship: BFO:0000050 GO:0009790 ! part of embryo development

[Term]
id: GO:0009887
name: animal organ morphogenesis
namespace: biological_process
def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
synonym: "histogenesis and organogenesis" BROAD []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ
relationship: BFO:0000050 GO:0048513 ! part of animal organ development
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002298 UBERON:0000062 ! results in morphogenesis of organ

[Term]
id: GO:0009888
name: tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
synonym: "histogenesis" EXACT []
synonym: "histogenesis and organogenesis" BROAD []
xref: Wikipedia:Histogenesis
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000479 ! results in development of tissue
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
relationship: RO:0002296 UBERON:0000479 ! results in development of tissue

[Term]
id: GO:0009889
name: regulation of biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "regulation of anabolism" EXACT []
synonym: "regulation of biosynthesis" EXACT []
synonym: "regulation of formation" EXACT []
synonym: "regulation of synthesis" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009058 ! regulates biosynthetic process
relationship: RO:0002211 GO:0009058 ! regulates biosynthetic process

[Term]
id: GO:0009890
name: negative regulation of biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "down regulation of biosynthetic process" EXACT []
synonym: "down-regulation of biosynthetic process" EXACT []
synonym: "downregulation of biosynthetic process" EXACT []
synonym: "inhibition of biosynthetic process" NARROW []
synonym: "negative regulation of anabolism" EXACT []
synonym: "negative regulation of biosynthesis" EXACT []
synonym: "negative regulation of formation" EXACT []
synonym: "negative regulation of synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process
relationship: RO:0002212 GO:0009058 ! negatively regulates biosynthetic process

[Term]
id: GO:0009891
name: positive regulation of biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "activation of biosynthetic process" NARROW []
synonym: "positive regulation of anabolism" EXACT []
synonym: "positive regulation of biosynthesis" EXACT []
synonym: "positive regulation of formation" EXACT []
synonym: "positive regulation of synthesis" EXACT []
synonym: "stimulation of biosynthetic process" NARROW []
synonym: "up regulation of biosynthetic process" EXACT []
synonym: "up-regulation of biosynthetic process" EXACT []
synonym: "upregulation of biosynthetic process" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009058 ! positively regulates biosynthetic process
relationship: RO:0002213 GO:0009058 ! positively regulates biosynthetic process

[Term]
id: GO:0009892
name: negative regulation of metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
synonym: "down regulation of metabolic process" EXACT []
synonym: "down-regulation of metabolic process" EXACT []
synonym: "downregulation of metabolic process" EXACT []
synonym: "inhibition of metabolic process" NARROW []
synonym: "inhibition of organismal metabolic process" NARROW []
synonym: "negative regulation of metabolism" EXACT []
synonym: "negative regulation of multicellular organismal metabolic process" NARROW []
synonym: "negative regulation of organismal metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008152 ! negatively regulates metabolic process
relationship: RO:0002212 GO:0008152 ! negatively regulates metabolic process

[Term]
id: GO:0009893
name: positive regulation of metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
synonym: "activation of metabolic process" NARROW []
synonym: "positive regulation of metabolism" EXACT []
synonym: "positive regulation of multicellular organismal metabolic process" NARROW []
synonym: "positive regulation of organismal metabolism" NARROW []
synonym: "stimulation of metabolic process" NARROW []
synonym: "stimulation of organismal metabolic process" NARROW []
synonym: "up regulation of metabolic process" EXACT []
synonym: "up-regulation of metabolic process" EXACT []
synonym: "up-regulation of organismal metabolic process" NARROW []
synonym: "upregulation of metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008152 ! positively regulates metabolic process
relationship: RO:0002213 GO:0008152 ! positively regulates metabolic process

[Term]
id: GO:0009894
name: regulation of catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "regulation of breakdown" EXACT []
synonym: "regulation of catabolism" EXACT []
synonym: "regulation of degradation" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process
relationship: RO:0002211 GO:0009056 ! regulates catabolic process

[Term]
id: GO:0009895
name: negative regulation of catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "down regulation of catabolic process" EXACT []
synonym: "down-regulation of catabolic process" EXACT []
synonym: "downregulation of catabolic process" EXACT []
synonym: "inhibition of catabolic process" NARROW []
synonym: "negative regulation of breakdown" EXACT []
synonym: "negative regulation of catabolism" EXACT []
synonym: "negative regulation of degradation" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009056 ! negatively regulates catabolic process
relationship: RO:0002212 GO:0009056 ! negatively regulates catabolic process

[Term]
id: GO:0009896
name: positive regulation of catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "activation of catabolic process" NARROW []
synonym: "positive regulation of breakdown" EXACT []
synonym: "positive regulation of catabolism" EXACT []
synonym: "positive regulation of degradation" EXACT []
synonym: "stimulation of catabolic process" NARROW []
synonym: "up regulation of catabolic process" EXACT []
synonym: "up-regulation of catabolic process" EXACT []
synonym: "upregulation of catabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009056 ! positively regulates catabolic process
relationship: RO:0002213 GO:0009056 ! positively regulates catabolic process

[Term]
id: GO:0009902
name: chloroplast relocation
namespace: biological_process
def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623]
synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0019750 ! chloroplast localization
is_a: GO:0051667 ! establishment of plastid localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 GO:0009507 ! has primary input chloroplast

[Term]
id: GO:0009913
name: epidermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell
relationship: BFO:0000050 GO:0008544 ! part of epidermis development
relationship: RO:0002315 CL:0000362 ! results in acquisition of features of epidermal cell

[Term]
id: GO:0009914
name: hormone transport
namespace: biological_process
def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]
subset: goslim_pir
is_a: GO:0006810 ! transport
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0009941
name: chloroplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]
is_a: GO:0009526 ! plastid envelope
relationship: BFO:0000050 GO:0009507 ! part of chloroplast

[Term]
id: GO:0009952
name: anterior/posterior pattern specification
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "anterior/posterior pattern formation" RELATED []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009966
name: regulation of signal transduction
namespace: biological_process
alt_id: GO:0035466
def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "regulation of signaling pathway" RELATED []
synonym: "regulation of signalling pathway" RELATED [GOC:mah]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007165 ! regulates signal transduction
relationship: RO:0002211 GO:0007165 ! regulates signal transduction

[Term]
id: GO:0009967
name: positive regulation of signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "activation of signal transduction" NARROW []
synonym: "positive regulation of signaling pathway" RELATED []
synonym: "positive regulation of signalling pathway" RELATED [GOC:mah]
synonym: "stimulation of signal transduction" NARROW []
synonym: "up regulation of signal transduction" EXACT []
synonym: "up-regulation of signal transduction" EXACT []
synonym: "upregulation of signal transduction" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007165 ! positively regulates signal transduction
relationship: RO:0002213 GO:0007165 ! positively regulates signal transduction

[Term]
id: GO:0009968
name: negative regulation of signal transduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "down regulation of signal transduction" EXACT []
synonym: "down-regulation of signal transduction" EXACT []
synonym: "downregulation of signal transduction" EXACT []
synonym: "inhibition of signal transduction" NARROW []
synonym: "negative regulation of signaling pathway" RELATED []
synonym: "negative regulation of signalling pathway" RELATED [GOC:mah]
xref: Reactome:R-HSA-8849472 "PTK6 Down-Regulation"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007165 ! negatively regulates signal transduction
relationship: RO:0002212 GO:0007165 ! negatively regulates signal transduction

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0044763
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
subset: goslim_plant
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
synonym: "single-organism cellular process" RELATED []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
created_by: jl
creation_date: 2012-12-11T16:56:55Z

[Term]
id: GO:0009994
name: oocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
synonym: "oocyte cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte
relationship: BFO:0000050 GO:0048477 ! part of oogenesis
relationship: RO:0002315 CL:0000023 ! results in acquisition of features of oocyte

[Term]
id: GO:0010001
name: glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
synonym: "glia cell differentiation" EXACT []
synonym: "neuroglia differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell
relationship: BFO:0000050 GO:0042063 ! part of gliogenesis
relationship: RO:0002315 CL:0000125 ! results in acquisition of features of glial cell

[Term]
id: GO:0010002
name: cardioblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart]
synonym: "cardioblast cell differentiation" EXACT []
synonym: "cardiomyocyte generation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast
relationship: RO:0002315 CL:0002664 ! results in acquisition of features of cardioblast

[Term]
id: GO:0010020
name: chloroplast fission
namespace: biological_process
def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr]
synonym: "chloroplast division" EXACT []
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0043572 ! plastid fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: GOREL:0002004 GO:0009507 ! results in fission of chloroplast
relationship: GOREL:0002004 GO:0009507 ! results in fission of chloroplast

[Term]
id: GO:0010032
name: meiotic chromosome condensation
namespace: biological_process
def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0030261 ! chromosome condensation
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle

[Term]
id: GO:0010070
name: zygote asymmetric cell division
namespace: biological_process
def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb]
synonym: "zygote asymmetric cytokinesis" RELATED []
is_a: GO:0008356 ! asymmetric cell division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: RO:0004009 CL:0000365 ! has primary input animal zygote
relationship: RO:0004009 CL:0000365 ! has primary input animal zygote

[Term]
id: GO:0010160
name: formation of animal organ boundary
namespace: biological_process
def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175]
synonym: "organ boundary specification" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048859 ! formation of anatomical boundary
intersection_of: BFO:0000066 UBERON:0000062 ! occurs in organ
relationship: BFO:0000050 GO:0048645 ! part of animal organ formation
relationship: BFO:0000066 UBERON:0000062 ! occurs in organ

[Term]
id: GO:0010171
name: body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism
relationship: RO:0002298 UBERON:0000468 ! results in morphogenesis of multicellular organism

[Term]
id: GO:0010256
name: endomembrane system organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm]
subset: goslim_drosophila
synonym: "endomembrane organization" EXACT []
synonym: "endomembrane system organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0012505 ! results in organization of endomembrane system
relationship: RO:0002592 GO:0012505 ! results in organization of endomembrane system

[Term]
id: GO:0010324
name: membrane invagination
namespace: biological_process
alt_id: GO:1902534
def: "The infolding of a membrane." [GOC:tb]
subset: goslim_yeast
synonym: "single-organism membrane invagination" RELATED []
is_a: GO:0061024 ! membrane organization
created_by: jl
creation_date: 2013-12-02T13:58:34Z

[Term]
id: GO:0010363
name: regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244]
comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'.
synonym: "regulation of HR" EXACT []
synonym: "regulation of HR-PCD" EXACT []
synonym: "regulation of plant hypersensitive response" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0080135 ! regulation of cellular response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009626 ! regulates plant-type hypersensitive response
relationship: RO:0002211 GO:0009626 ! regulates plant-type hypersensitive response

[Term]
id: GO:0010453
name: regulation of cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045165 ! regulates cell fate commitment
relationship: RO:0002211 GO:0045165 ! regulates cell fate commitment

[Term]
id: GO:0010454
name: negative regulation of cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment
relationship: RO:0002212 GO:0045165 ! negatively regulates cell fate commitment

[Term]
id: GO:0010455
name: positive regulation of cell fate commitment
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045165 ! positively regulates cell fate commitment
relationship: RO:0002213 GO:0045165 ! positively regulates cell fate commitment

[Term]
id: GO:0010463
name: mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell
relationship: RO:0012003 CL:0008019 ! acts on population of mesenchymal cell

[Term]
id: GO:0010464
name: regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation
relationship: RO:0002211 GO:0010463 ! regulates mesenchymal cell proliferation

[Term]
id: GO:0010467
name: gene expression
namespace: biological_process
def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
subset: goslim_flybase_ribbon
xref: Wikipedia:Gene_expression
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010468
name: regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_plant_ribbon
synonym: "gene regulation" RELATED [GOC:cjm]
synonym: "regulation of gene product expression" RELATED []
synonym: "regulation of protein expression" NARROW []
xref: Reactome:R-HSA-163767 "PP2A-mediated dephosphorylation of key metabolic factors"
xref: Reactome:R-HSA-9752946 "Expression and translocation of olfactory receptors"
xref: Wikipedia:Regulation_of_gene_expression
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010467 ! regulates gene expression
relationship: RO:0002211 GO:0010467 ! regulates gene expression

[Term]
id: GO:0010469
name: regulation of signaling receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "regulation of receptor activity" BROAD []
synonym: "regulation of signalling receptor activity" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0038023 ! regulates signaling receptor activity
relationship: RO:0002211 GO:0038023 ! regulates signaling receptor activity

[Term]
id: GO:0010470
name: regulation of gastrulation
namespace: biological_process
def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007369 ! regulates gastrulation
relationship: RO:0002211 GO:0007369 ! regulates gastrulation

[Term]
id: GO:0010481
name: epidermal cell division
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124]
synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000362 ! has primary input epidermal cell
relationship: RO:0004009 CL:0000362 ! has primary input epidermal cell

[Term]
id: GO:0010482
name: regulation of epidermal cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124]
synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010481 ! regulates epidermal cell division
relationship: RO:0002211 GO:0010481 ! regulates epidermal cell division

[Term]
id: GO:0010496
name: intercellular transport
namespace: biological_process
def: "The movement of substances between cells." [GOC:dhl]
synonym: "single organism intercellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism intercellular transport" RELATED []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 CL:0000000 ! has target start location cell
intersection_of: RO:0002339 CL:0000000 ! has target end location cell
intersection_of: RO:0002342 GO:0005615 ! results in transport across extracellular space
relationship: RO:0002338 CL:0000000 ! has target start location cell
relationship: RO:0002339 CL:0000000 ! has target end location cell
relationship: RO:0002342 GO:0005615 ! results in transport across extracellular space
creation_date: 2013-12-19T13:24:56Z

[Term]
id: GO:0010506
name: regulation of autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006914 ! regulates autophagy
relationship: RO:0002211 GO:0006914 ! regulates autophagy

[Term]
id: GO:0010549
name: regulation of membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030397 ! regulates membrane disassembly
relationship: RO:0002211 GO:0030397 ! regulates membrane disassembly

[Term]
id: GO:0010556
name: regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process
relationship: RO:0002211 GO:0009059 ! regulates macromolecule biosynthetic process

[Term]
id: GO:0010557
name: positive regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process
relationship: RO:0002213 GO:0009059 ! positively regulates macromolecule biosynthetic process

[Term]
id: GO:0010558
name: negative regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process
relationship: RO:0002212 GO:0009059 ! negatively regulates macromolecule biosynthetic process

[Term]
id: GO:0010559
name: regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process
relationship: RO:0002211 GO:0009101 ! regulates glycoprotein biosynthetic process

[Term]
id: GO:0010560
name: positive regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process
relationship: RO:0002213 GO:0009101 ! positively regulates glycoprotein biosynthetic process

[Term]
id: GO:0010561
name: negative regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process
relationship: RO:0002212 GO:0009101 ! negatively regulates glycoprotein biosynthetic process

[Term]
id: GO:0010562
name: positive regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006793 ! positively regulates phosphorus metabolic process
relationship: RO:0002213 GO:0006793 ! positively regulates phosphorus metabolic process

[Term]
id: GO:0010563
name: negative regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006793 ! negatively regulates phosphorus metabolic process
relationship: RO:0002212 GO:0006793 ! negatively regulates phosphorus metabolic process

[Term]
id: GO:0010564
name: regulation of cell cycle process
namespace: biological_process
def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022402 ! regulates cell cycle process
relationship: RO:0002211 GO:0022402 ! regulates cell cycle process

[Term]
id: GO:0010565
name: regulation of ketone metabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042180 ! regulates ketone metabolic process
relationship: RO:0002211 GO:0042180 ! regulates ketone metabolic process

[Term]
id: GO:0010566
name: regulation of ketone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0010565 ! regulation of ketone metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process
relationship: RO:0002211 GO:0042181 ! regulates ketone biosynthetic process

[Term]
id: GO:0010570
name: regulation of filamentous growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0040008 ! regulation of growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030447 ! regulates filamentous growth
relationship: RO:0002211 GO:0030447 ! regulates filamentous growth

[Term]
id: GO:0010594
name: regulation of endothelial cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043542 ! regulates endothelial cell migration
relationship: RO:0002211 GO:0043542 ! regulates endothelial cell migration

[Term]
id: GO:0010595
name: positive regulation of endothelial cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration
relationship: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration

[Term]
id: GO:0010596
name: negative regulation of endothelial cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration
relationship: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration

[Term]
id: GO:0010604
name: positive regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process
relationship: RO:0002213 GO:0043170 ! positively regulates macromolecule metabolic process

[Term]
id: GO:0010605
name: negative regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process
relationship: RO:0002212 GO:0043170 ! negatively regulates macromolecule metabolic process

[Term]
id: GO:0010608
name: post-transcriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]
synonym: "posttranscriptional regulation of gene expression" EXACT []
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0010611
name: regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy
relationship: RO:0002211 GO:0003300 ! regulates cardiac muscle hypertrophy

[Term]
id: GO:0010612
name: regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb]
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation
relationship: RO:0002211 GO:0014887 ! regulates cardiac muscle adaptation

[Term]
id: GO:0010613
name: positive regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy
relationship: RO:0002213 GO:0003300 ! positively regulates cardiac muscle hypertrophy

[Term]
id: GO:0010614
name: negative regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy
relationship: RO:0002212 GO:0003300 ! negatively regulates cardiac muscle hypertrophy

[Term]
id: GO:0010615
name: positive regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014744 ! positive regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation
relationship: RO:0002213 GO:0014887 ! positively regulates cardiac muscle adaptation

[Term]
id: GO:0010616
name: negative regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014745 ! negative regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation
relationship: RO:0002212 GO:0014887 ! negatively regulates cardiac muscle adaptation

[Term]
id: GO:0010623
name: programmed cell death involved in cell development
namespace: biological_process
def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure.
synonym: "developmental programmed cell death" BROAD []
synonym: "programmed cell death involved in development" BROAD []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0012501 ! programmed cell death
intersection_of: BFO:0000050 GO:0048468 ! part of cell development
relationship: BFO:0000050 GO:0048468 ! part of cell development

[Term]
id: GO:0010624
name: regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014010 ! regulates Schwann cell proliferation
relationship: RO:0002211 GO:0014010 ! regulates Schwann cell proliferation

[Term]
id: GO:0010625
name: positive regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060252 ! positive regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014010 ! positively regulates Schwann cell proliferation
relationship: RO:0002213 GO:0014010 ! positively regulates Schwann cell proliferation

[Term]
id: GO:0010626
name: negative regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060253 ! negative regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014010 ! negatively regulates Schwann cell proliferation
relationship: RO:0002212 GO:0014010 ! negatively regulates Schwann cell proliferation

[Term]
id: GO:0010628
name: positive regulation of gene expression
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010467 ! positively regulates gene expression
relationship: RO:0002213 GO:0010467 ! positively regulates gene expression

[Term]
id: GO:0010629
name: negative regulation of gene expression
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
synonym: "gene silencing" RELATED []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010467 ! negatively regulates gene expression
relationship: RO:0002212 GO:0010467 ! negatively regulates gene expression

[Term]
id: GO:0010631
name: epithelial cell migration
namespace: biological_process
def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000066 ! results in movement of epithelial cell
relationship: BFO:0000050 GO:0090132 ! part of epithelium migration
relationship: RO:0002565 CL:0000066 ! results in movement of epithelial cell

[Term]
id: GO:0010632
name: regulation of epithelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010631 ! regulates epithelial cell migration
relationship: RO:0002211 GO:0010631 ! regulates epithelial cell migration

[Term]
id: GO:0010633
name: negative regulation of epithelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010631 ! negatively regulates epithelial cell migration
relationship: RO:0002212 GO:0010631 ! negatively regulates epithelial cell migration

[Term]
id: GO:0010634
name: positive regulation of epithelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010631 ! positively regulates epithelial cell migration
relationship: RO:0002213 GO:0010631 ! positively regulates epithelial cell migration

[Term]
id: GO:0010635
name: regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008053 ! regulates mitochondrial fusion
relationship: RO:0002211 GO:0008053 ! regulates mitochondrial fusion

[Term]
id: GO:0010636
name: positive regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008053 ! positively regulates mitochondrial fusion
relationship: RO:0002213 GO:0008053 ! positively regulates mitochondrial fusion

[Term]
id: GO:0010637
name: negative regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008053 ! negatively regulates mitochondrial fusion
relationship: RO:0002212 GO:0008053 ! negatively regulates mitochondrial fusion

[Term]
id: GO:0010638
name: positive regulation of organelle organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "positive regulation of organelle organisation" EXACT [GOC:mah]
synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006996 ! positively regulates organelle organization
relationship: RO:0002213 GO:0006996 ! positively regulates organelle organization

[Term]
id: GO:0010639
name: negative regulation of organelle organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "negative regulation of organelle organisation" EXACT [GOC:mah]
synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006996 ! negatively regulates organelle organization
relationship: RO:0002212 GO:0006996 ! negatively regulates organelle organization

[Term]
id: GO:0010646
name: regulation of cell communication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007154 ! regulates cell communication
relationship: RO:0002211 GO:0007154 ! regulates cell communication

[Term]
id: GO:0010647
name: positive regulation of cell communication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007154 ! positively regulates cell communication
relationship: RO:0002213 GO:0007154 ! positively regulates cell communication

[Term]
id: GO:0010648
name: negative regulation of cell communication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007154 ! negatively regulates cell communication
relationship: RO:0002212 GO:0007154 ! negatively regulates cell communication

[Term]
id: GO:0010656
name: negative regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "negative regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process
relationship: RO:0002212 GO:0010657 ! negatively regulates muscle cell apoptotic process

[Term]
id: GO:0010657
name: muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "muscle cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell
relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0010658
name: striated muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "striated muscle cell apoptosis" NARROW []
is_a: GO:0010657 ! muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000737 ! occurs in striated muscle cell
relationship: BFO:0000066 CL:0000737 ! occurs in striated muscle cell

[Term]
id: GO:0010659
name: cardiac muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010658 ! striated muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell
relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell

[Term]
id: GO:0010660
name: regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of muscle cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process
relationship: RO:0002211 GO:0010657 ! regulates muscle cell apoptotic process

[Term]
id: GO:0010661
name: positive regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process
relationship: RO:0002213 GO:0010657 ! positively regulates muscle cell apoptotic process

[Term]
id: GO:0010662
name: regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process
relationship: RO:0002211 GO:0010658 ! regulates striated muscle cell apoptotic process

[Term]
id: GO:0010663
name: positive regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process
relationship: RO:0002213 GO:0010658 ! positively regulates striated muscle cell apoptotic process

[Term]
id: GO:0010664
name: negative regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process
relationship: RO:0002212 GO:0010658 ! negatively regulates striated muscle cell apoptotic process

[Term]
id: GO:0010665
name: regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process
relationship: RO:0002211 GO:0010659 ! regulates cardiac muscle cell apoptotic process

[Term]
id: GO:0010666
name: positive regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process
relationship: RO:0002213 GO:0010659 ! positively regulates cardiac muscle cell apoptotic process

[Term]
id: GO:0010667
name: negative regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process
relationship: RO:0002212 GO:0010659 ! negatively regulates cardiac muscle cell apoptotic process

[Term]
id: GO:0010668
name: ectodermal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell
relationship: BFO:0000050 GO:0007398 ! part of ectoderm development
relationship: RO:0002315 CL:0000221 ! results in acquisition of features of ectodermal cell

[Term]
id: GO:0010700
name: negative regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion
relationship: RO:0002212 GO:0048243 ! negatively regulates norepinephrine secretion

[Term]
id: GO:0010701
name: positive regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion
relationship: RO:0002213 GO:0048243 ! positively regulates norepinephrine secretion

[Term]
id: GO:0010710
name: regulation of collagen catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030574 ! regulates collagen catabolic process
relationship: RO:0002211 GO:0030574 ! regulates collagen catabolic process

[Term]
id: GO:0010711
name: negative regulation of collagen catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process
relationship: RO:0002212 GO:0030574 ! negatively regulates collagen catabolic process

[Term]
id: GO:0010712
name: regulation of collagen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032963 ! regulates collagen metabolic process
relationship: RO:0002211 GO:0032963 ! regulates collagen metabolic process

[Term]
id: GO:0010713
name: negative regulation of collagen metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process
relationship: RO:0002212 GO:0032963 ! negatively regulates collagen metabolic process

[Term]
id: GO:0010714
name: positive regulation of collagen metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process
relationship: RO:0002213 GO:0032963 ! positively regulates collagen metabolic process

[Term]
id: GO:0010715
name: regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly
relationship: RO:0002211 GO:0022617 ! regulates extracellular matrix disassembly

[Term]
id: GO:0010716
name: negative regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly
relationship: RO:0002212 GO:0022617 ! negatively regulates extracellular matrix disassembly

[Term]
id: GO:0010717
name: regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition
relationship: RO:0002211 GO:0001837 ! regulates epithelial to mesenchymal transition

[Term]
id: GO:0010718
name: positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition
relationship: RO:0002213 GO:0001837 ! positively regulates epithelial to mesenchymal transition

[Term]
id: GO:0010719
name: negative regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition
relationship: RO:0002212 GO:0001837 ! negatively regulates epithelial to mesenchymal transition

[Term]
id: GO:0010720
name: positive regulation of cell development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048468 ! positively regulates cell development
relationship: RO:0002213 GO:0048468 ! positively regulates cell development

[Term]
id: GO:0010721
name: negative regulation of cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048468 ! negatively regulates cell development
relationship: RO:0002212 GO:0048468 ! negatively regulates cell development

[Term]
id: GO:0010758
name: regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:1905521 ! regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048246 ! regulates macrophage chemotaxis
relationship: RO:0002211 GO:0048246 ! regulates macrophage chemotaxis

[Term]
id: GO:0010759
name: positive regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:1905523 ! positive regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048246 ! positively regulates macrophage chemotaxis
relationship: RO:0002213 GO:0048246 ! positively regulates macrophage chemotaxis

[Term]
id: GO:0010760
name: negative regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
is_a: GO:1905522 ! negative regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048246 ! negatively regulates macrophage chemotaxis
relationship: RO:0002212 GO:0048246 ! negatively regulates macrophage chemotaxis

[Term]
id: GO:0010761
name: fibroblast migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000057 ! results in movement of fibroblast
relationship: RO:0002565 CL:0000057 ! results in movement of fibroblast

[Term]
id: GO:0010762
name: regulation of fibroblast migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010761 ! regulates fibroblast migration
relationship: RO:0002211 GO:0010761 ! regulates fibroblast migration

[Term]
id: GO:0010763
name: positive regulation of fibroblast migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010761 ! positively regulates fibroblast migration
relationship: RO:0002213 GO:0010761 ! positively regulates fibroblast migration

[Term]
id: GO:0010764
name: negative regulation of fibroblast migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010761 ! negatively regulates fibroblast migration
relationship: RO:0002212 GO:0010761 ! negatively regulates fibroblast migration

[Term]
id: GO:0010770
name: positive regulation of cell morphogenesis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0022604 ! regulation of cell morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis
relationship: RO:0002213 GO:0000902 ! positively regulates cell morphogenesis

[Term]
id: GO:0010771
name: negative regulation of cell morphogenesis
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0022604 ! regulation of cell morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis
relationship: RO:0002212 GO:0000902 ! negatively regulates cell morphogenesis

[Term]
id: GO:0010817
name: regulation of hormone levels
namespace: biological_process
def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0010818
name: T cell chemotaxis
namespace: biological_process
def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb]
synonym: "T-cell chemotaxis" EXACT [CL:0000084]
is_a: GO:0048247 ! lymphocyte chemotaxis
is_a: GO:0072678 ! T cell migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000084 ! results in movement of T cell

[Term]
id: GO:0010819
name: regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010818 ! regulates T cell chemotaxis
relationship: RO:0002211 GO:0010818 ! regulates T cell chemotaxis

[Term]
id: GO:0010820
name: positive regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010819 ! regulation of T cell chemotaxis
is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis
is_a: GO:2000406 ! positive regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010818 ! positively regulates T cell chemotaxis
relationship: RO:0002213 GO:0010818 ! positively regulates T cell chemotaxis

[Term]
id: GO:0010821
name: regulation of mitochondrion organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007005 ! regulates mitochondrion organization
relationship: RO:0002211 GO:0007005 ! regulates mitochondrion organization

[Term]
id: GO:0010830
name: regulation of myotube differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014902 ! regulates myotube differentiation
relationship: RO:0002211 GO:0014902 ! regulates myotube differentiation

[Term]
id: GO:0010831
name: positive regulation of myotube differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014902 ! positively regulates myotube differentiation
relationship: RO:0002213 GO:0014902 ! positively regulates myotube differentiation

[Term]
id: GO:0010832
name: negative regulation of myotube differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation
relationship: RO:0002212 GO:0014902 ! negatively regulates myotube differentiation

[Term]
id: GO:0010842
name: retina layer formation
namespace: biological_process
def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]
synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb]
synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001781 ! results in formation of layer of retina
relationship: BFO:0000050 GO:0003407 ! part of neural retina development
relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye
relationship: RO:0002297 UBERON:0001781 ! results in formation of layer of retina

[Term]
id: GO:0010876
name: lipid localization
namespace: biological_process
def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "lipid localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
intersection_of: GO:0033036 ! macromolecule localization
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0010892
name: positive regulation of mitochondrial translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0070131 ! positive regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation

[Term]
id: GO:0010893
name: positive regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process
relationship: RO:0002213 GO:0006694 ! positively regulates steroid biosynthetic process

[Term]
id: GO:0010894
name: negative regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process
relationship: RO:0002212 GO:0006694 ! negatively regulates steroid biosynthetic process

[Term]
id: GO:0010927
name: cellular component assembly involved in morphogenesis
namespace: biological_process
def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis
relationship: BFO:0000050 GO:0032989 ! part of cellular anatomical entity morphogenesis

[Term]
id: GO:0010934
name: macrophage cytokine production
namespace: biological_process
def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0061082 ! myeloid leukocyte cytokine production
intersection_of: GO:0001816 ! cytokine production
intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage
relationship: BFO:0000066 CL:0000235 ! occurs in macrophage

[Term]
id: GO:0010935
name: regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010934 ! regulates macrophage cytokine production
relationship: RO:0002211 GO:0010934 ! regulates macrophage cytokine production

[Term]
id: GO:0010936
name: negative regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0010935 ! regulation of macrophage cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010934 ! negatively regulates macrophage cytokine production
relationship: RO:0002212 GO:0010934 ! negatively regulates macrophage cytokine production

[Term]
id: GO:0010937
name: regulation of cytoplasmic microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb]
is_a: GO:0031114 ! regulation of microtubule depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization
relationship: RO:0002211 GO:0010938 ! regulates cytoplasmic microtubule depolymerization

[Term]
id: GO:0010938
name: cytoplasmic microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0031122 ! cytoplasmic microtubule organization
intersection_of: GO:0007019 ! microtubule depolymerization
intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm
relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm

[Term]
id: GO:0010948
name: negative regulation of cell cycle process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0022402 ! negatively regulates cell cycle process
relationship: RO:0002212 GO:0022402 ! negatively regulates cell cycle process
creation_date: 2009-04-27T09:53:22Z

[Term]
id: GO:0010958
name: regulation of amino acid import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb]
synonym: "regulation of amino acid import" BROAD []
is_a: GO:1903789 ! regulation of amino acid transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0089718 ! regulates amino acid import across plasma membrane
relationship: RO:0002211 GO:0089718 ! regulates amino acid import across plasma membrane
creation_date: 2009-05-06T11:33:12Z

[Term]
id: GO:0010968
name: regulation of microtubule nucleation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0031113 ! regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007020 ! regulates microtubule nucleation
relationship: RO:0002211 GO:0007020 ! regulates microtubule nucleation
creation_date: 2009-05-20T11:51:21Z

[Term]
id: GO:0010970
name: transport along microtubule
namespace: biological_process
def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph]
synonym: "microtubule-based transport" BROAD []
synonym: "movement along microtubule" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0099111 ! microtubule-based transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: RO:0002341 GO:0005874 ! results in transport along microtubule
creation_date: 2009-05-27T10:56:08Z

[Term]
id: GO:0010975
name: regulation of neuron projection development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "regulation of neurite development" NARROW [GOC:mah]
synonym: "regulation of neurite formation" NARROW [GOC:mah]
synonym: "regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0031175 ! regulates neuron projection development
relationship: RO:0002211 GO:0031175 ! regulates neuron projection development
creation_date: 2009-06-01T10:44:45Z

[Term]
id: GO:0010976
name: positive regulation of neuron projection development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "positive regulation of neurite development" NARROW [GOC:mah]
synonym: "positive regulation of neurite formation" NARROW [GOC:mah]
synonym: "positive regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031346 ! positive regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0031175 ! positively regulates neuron projection development
relationship: RO:0002213 GO:0031175 ! positively regulates neuron projection development
creation_date: 2009-06-01T10:46:44Z

[Term]
id: GO:0010977
name: negative regulation of neuron projection development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "growth cone collapse" RELATED [GOC:pr]
synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "negative regulation of neurite development" NARROW [GOC:mah]
synonym: "negative regulation of neurite formation" NARROW [GOC:mah]
synonym: "negative regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031345 ! negative regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0031175 ! negatively regulates neuron projection development
relationship: RO:0002212 GO:0031175 ! negatively regulates neuron projection development
creation_date: 2009-06-01T10:47:42Z

[Term]
id: GO:0012501
name: programmed cell death
namespace: biological_process
alt_id: GO:0016244
def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_prokaryote
synonym: "caspase-independent apoptosis" RELATED []
synonym: "caspase-independent cell death" NARROW []
synonym: "non-apoptotic programmed cell death" NARROW []
synonym: "nonapoptotic programmed cell death" NARROW []
synonym: "PCD" RELATED []
synonym: "RCD" RELATED []
synonym: "regulated cell death" BROAD []
xref: Reactome:R-HSA-5357801 "Programmed Cell Death"
xref: Wikipedia:Programmed_cell_death
is_a: GO:0008219 ! cell death
intersection_of: GO:0008219 ! cell death
intersection_of: RO:0002224 GO:0007165 ! starts with signal transduction
relationship: RO:0002224 GO:0007165 ! starts with signal transduction

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_candida
subset: goslim_flybase_ribbon
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell
relationship: BFO:0000051 GO:0005773 ! has part vacuole
relationship: BFO:0000051 GO:0005886 ! has part plasma membrane

[Term]
id: GO:0012506
name: vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]
xref: NIF_Subcellular:sao1153182838
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0031982 ! part of vesicle
relationship: BFO:0000050 GO:0031982 ! part of vesicle

[Term]
id: GO:0014000
name: morula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the morula over time. The morula is a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745]
is_a: GO:0009790 ! embryo development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000085 ! results in development of morula
relationship: RO:0002296 UBERON:0000085 ! results in development of morula
creation_date: 2024-11-12T09:13:07Z

[Term]
id: GO:0014002
name: astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef]
synonym: "astrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000127 ! results in development of astrocyte
relationship: BFO:0000050 GO:0048708 ! part of astrocyte differentiation
relationship: RO:0002296 CL:0000127 ! results in development of astrocyte

[Term]
id: GO:0014003
name: oligodendrocyte development
namespace: biological_process
def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef]
synonym: "oligodendrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000128 ! results in development of oligodendrocyte
relationship: BFO:0000050 GO:0048709 ! part of oligodendrocyte differentiation
relationship: RO:0002296 CL:0000128 ! results in development of oligodendrocyte

[Term]
id: GO:0014004
name: microglia differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef]
synonym: "microglial cell differentiation" EXACT []
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0030225 ! macrophage differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000129 ! results in acquisition of features of microglial cell
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002315 CL:0000129 ! results in acquisition of features of microglial cell

[Term]
id: GO:0014005
name: microglia development
namespace: biological_process
def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef]
synonym: "microglial cell development" EXACT []
is_a: GO:0021782 ! glial cell development
is_a: GO:0061515 ! myeloid cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000129 ! results in development of microglial cell
relationship: BFO:0000050 GO:0014004 ! part of microglia differentiation
relationship: RO:0002296 CL:0000129 ! results in development of microglial cell

[Term]
id: GO:0014006
name: regulation of microglia differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "regulation of microglial cell differentiation" EXACT []
is_a: GO:0045649 ! regulation of macrophage differentiation
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014004 ! regulates microglia differentiation
relationship: RO:0002211 GO:0014004 ! regulates microglia differentiation

[Term]
id: GO:0014007
name: negative regulation of microglia differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "down regulation of microglia differentiation" EXACT []
synonym: "down-regulation of microglia differentiation" EXACT []
synonym: "downregulation of microglia differentiation" EXACT []
synonym: "inhibition of microglia differentiation" NARROW []
synonym: "negative regulation of microglial cell differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045650 ! negative regulation of macrophage differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014004 ! negatively regulates microglia differentiation
relationship: RO:0002212 GO:0014004 ! negatively regulates microglia differentiation

[Term]
id: GO:0014008
name: positive regulation of microglia differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "activation of microglia differentiation" NARROW []
synonym: "positive regulation of microglial cell differentiation" EXACT []
synonym: "stimulation of microglia differentiation" NARROW []
synonym: "up regulation of microglia differentiation" EXACT []
synonym: "up-regulation of microglia differentiation" EXACT []
synonym: "upregulation of microglia differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045651 ! positive regulation of macrophage differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014004 ! positively regulates microglia differentiation
relationship: RO:0002213 GO:0014004 ! positively regulates microglia differentiation

[Term]
id: GO:0014009
name: glial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
synonym: "glia proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000125 ! acts on population of glial cell
relationship: BFO:0000050 GO:0042063 ! part of gliogenesis
relationship: RO:0012003 CL:0000125 ! acts on population of glial cell

[Term]
id: GO:0014010
name: Schwann cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014009 ! glial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000218 ! acts on population of myelinating Schwann cell
relationship: RO:0012003 CL:0000218 ! acts on population of myelinating Schwann cell

[Term]
id: GO:0014013
name: regulation of gliogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
is_a: GO:0050767 ! regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042063 ! regulates gliogenesis
relationship: RO:0002211 GO:0042063 ! regulates gliogenesis

[Term]
id: GO:0014014
name: negative regulation of gliogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "down regulation of gliogenesis" EXACT []
synonym: "down-regulation of gliogenesis" EXACT []
synonym: "downregulation of gliogenesis" EXACT []
synonym: "inhibition of gliogenesis" NARROW []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042063 ! negatively regulates gliogenesis
relationship: RO:0002212 GO:0042063 ! negatively regulates gliogenesis

[Term]
id: GO:0014015
name: positive regulation of gliogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "activation of gliogenesis" NARROW []
synonym: "stimulation of gliogenesis" NARROW []
synonym: "up regulation of gliogenesis" EXACT []
synonym: "up-regulation of gliogenesis" EXACT []
synonym: "upregulation of gliogenesis" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042063 ! positively regulates gliogenesis
relationship: RO:0002213 GO:0042063 ! positively regulates gliogenesis

[Term]
id: GO:0014016
name: neuroblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata)
relationship: BFO:0000050 GO:0048699 ! part of generation of neurons
relationship: RO:0002315 CL:0000031 ! results in acquisition of features of neuroblast (sensu Vertebrata)

[Term]
id: GO:0014019
name: neuroblast development
namespace: biological_process
def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata)
relationship: BFO:0000050 GO:0014016 ! part of neuroblast differentiation
relationship: RO:0002296 CL:0000031 ! results in development of neuroblast (sensu Vertebrata)

[Term]
id: GO:0014020
name: primary neural tube formation
namespace: biological_process
def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780]
synonym: "neural rod cavitation" RELATED []
synonym: "primary neural tube morphogenesis" EXACT [GOC:dph]
synonym: "primary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: BFO:0000050 GO:0001841 ! part of neural tube formation

[Term]
id: GO:0014023
name: neural rod formation
namespace: biological_process
def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005068 ! results in formation of neural rod
relationship: BFO:0000050 GO:0014020 ! part of primary neural tube formation
relationship: RO:0002162 NCBITaxon:32443 ! in taxon Teleostei
relationship: RO:0002297 UBERON:0005068 ! results in formation of neural rod

[Term]
id: GO:0014025
name: neural keel formation
namespace: biological_process
def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0007135 ! results in formation of neural keel
relationship: BFO:0000050 GO:0014023 ! part of neural rod formation
relationship: RO:0002297 UBERON:0007135 ! results in formation of neural keel

[Term]
id: GO:0014028
name: notochord formation
namespace: biological_process
def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002328 ! results in formation of notochord
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: BFO:0000050 GO:0048570 ! part of notochord morphogenesis
relationship: RO:0002297 UBERON:0002328 ! results in formation of notochord

[Term]
id: GO:0014029
name: neural crest formation
namespace: biological_process
def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:dh, GOC:ef]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002342 ! results in formation of neural crest
relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002297 UBERON:0002342 ! results in formation of neural crest

[Term]
id: GO:0014031
name: mesenchymal cell development
namespace: biological_process
def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0008019 ! results in development of mesenchymal cell
relationship: BFO:0000050 GO:0048762 ! part of mesenchymal cell differentiation
relationship: RO:0002296 CL:0008019 ! results in development of mesenchymal cell

[Term]
id: GO:0014032
name: neural crest cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048864 ! stem cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0011012 ! results in development of neural crest cell
relationship: BFO:0000050 GO:0014033 ! part of neural crest cell differentiation
relationship: RO:0002296 CL:0011012 ! results in development of neural crest cell

[Term]
id: GO:0014033
name: neural crest cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002315 CL:0000333 ! results in acquisition of features of migratory neural crest cell

[Term]
id: GO:0014037
name: Schwann cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef]
is_a: GO:0010001 ! glial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000218 ! results in acquisition of features of myelinating Schwann cell
relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002315 CL:0000218 ! results in acquisition of features of myelinating Schwann cell

[Term]
id: GO:0014038
name: regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014037 ! regulates Schwann cell differentiation
relationship: RO:0002211 GO:0014037 ! regulates Schwann cell differentiation

[Term]
id: GO:0014039
name: negative regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "down regulation of Schwann cell differentiation" EXACT []
synonym: "down-regulation of Schwann cell differentiation" EXACT []
synonym: "downregulation of Schwann cell differentiation" EXACT []
synonym: "inhibition of Schwann cell differentiation" NARROW []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014037 ! negatively regulates Schwann cell differentiation
relationship: RO:0002212 GO:0014037 ! negatively regulates Schwann cell differentiation

[Term]
id: GO:0014040
name: positive regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "activation of Schwann cell differentiation" NARROW []
synonym: "stimulation of Schwann cell differentiation" NARROW []
synonym: "up regulation of Schwann cell differentiation" EXACT []
synonym: "up-regulation of Schwann cell differentiation" EXACT []
synonym: "upregulation of Schwann cell differentiation" EXACT []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014037 ! positively regulates Schwann cell differentiation
relationship: RO:0002213 GO:0014037 ! positively regulates Schwann cell differentiation

[Term]
id: GO:0014041
name: regulation of neuron maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042551 ! regulates neuron maturation
relationship: RO:0002211 GO:0042551 ! regulates neuron maturation

[Term]
id: GO:0014042
name: positive regulation of neuron maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "activation of neuron maturation" NARROW []
synonym: "stimulation of neuron maturation" NARROW []
synonym: "up regulation of neuron maturation" EXACT []
synonym: "up-regulation of neuron maturation" EXACT []
synonym: "upregulation of neuron maturation" EXACT []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:1903431 ! positive regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042551 ! positively regulates neuron maturation
relationship: RO:0002213 GO:0042551 ! positively regulates neuron maturation

[Term]
id: GO:0014043
name: negative regulation of neuron maturation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "down regulation of neuron maturation" EXACT []
synonym: "down-regulation of neuron maturation" EXACT []
synonym: "downregulation of neuron maturation" EXACT []
synonym: "inhibition of neuron maturation" NARROW []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:1903430 ! negative regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042551 ! negatively regulates neuron maturation
relationship: RO:0002212 GO:0042551 ! negatively regulates neuron maturation

[Term]
id: GO:0014044
name: Schwann cell development
namespace: biological_process
def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef]
is_a: GO:0021782 ! glial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000218 ! results in development of myelinating Schwann cell
relationship: BFO:0000050 GO:0014037 ! part of Schwann cell differentiation
relationship: RO:0002296 CL:0000218 ! results in development of myelinating Schwann cell

[Term]
id: GO:0014046
name: dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0023061 ! signal release
is_a: GO:0050432 ! catecholamine secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:59905 ! has primary input

[Term]
id: GO:0014047
name: glutamate secretion
namespace: biological_process
def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:14321 ! has primary input
relationship: RO:0004009 CHEBI:14321 ! has primary input

[Term]
id: GO:0014048
name: regulation of glutamate secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014047 ! regulates glutamate secretion
relationship: RO:0002211 GO:0014047 ! regulates glutamate secretion

[Term]
id: GO:0014049
name: positive regulation of glutamate secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "activation of glutamate secretion" NARROW []
synonym: "stimulation of glutamate secretion" NARROW []
synonym: "up regulation of glutamate secretion" EXACT []
synonym: "up-regulation of glutamate secretion" EXACT []
synonym: "upregulation of glutamate secretion" EXACT []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014047 ! positively regulates glutamate secretion
relationship: RO:0002213 GO:0014047 ! positively regulates glutamate secretion

[Term]
id: GO:0014050
name: negative regulation of glutamate secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "down regulation of glutamate secretion" EXACT []
synonym: "down-regulation of glutamate secretion" EXACT []
synonym: "downregulation of glutamate secretion" EXACT []
synonym: "inhibition of glutamate secretion" NARROW []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014047 ! negatively regulates glutamate secretion
relationship: RO:0002212 GO:0014047 ! negatively regulates glutamate secretion

[Term]
id: GO:0014051
name: gamma-aminobutyric acid secretion
namespace: biological_process
def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef]
synonym: "GABA secretion" EXACT []
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0046717 ! acid secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:59888 ! has primary input

[Term]
id: GO:0014052
name: regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "regulation of GABA secretion" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014051 ! regulates gamma-aminobutyric acid secretion
relationship: RO:0002211 GO:0014051 ! regulates gamma-aminobutyric acid secretion

[Term]
id: GO:0014053
name: negative regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW []
synonym: "negative regulation of GABA secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014051 ! negatively regulates gamma-aminobutyric acid secretion
relationship: RO:0002212 GO:0014051 ! negatively regulates gamma-aminobutyric acid secretion

[Term]
id: GO:0014054
name: positive regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "activation of gamma-aminobutyric acid secretion" NARROW []
synonym: "positive regulation of GABA secretion" EXACT []
synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW []
synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014051 ! positively regulates gamma-aminobutyric acid secretion
relationship: RO:0002213 GO:0014051 ! positively regulates gamma-aminobutyric acid secretion

[Term]
id: GO:0014055
name: acetylcholine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061526 ! acetylcholine secretion
intersection_of: GO:0061526 ! acetylcholine secretion
intersection_of: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic
relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic

[Term]
id: GO:0014056
name: regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission
relationship: RO:0002211 GO:0014055 ! regulates acetylcholine secretion, neurotransmission

[Term]
id: GO:0014057
name: positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "activation of acetylcholine secretion" NARROW []
synonym: "stimulation of acetylcholine secretion" NARROW []
synonym: "up regulation of acetylcholine secretion" EXACT []
synonym: "up-regulation of acetylcholine secretion" EXACT []
synonym: "upregulation of acetylcholine secretion" EXACT []
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic
is_a: GO:0051954 ! positive regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission
relationship: RO:0002213 GO:0014055 ! positively regulates acetylcholine secretion, neurotransmission

[Term]
id: GO:0014058
name: negative regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "down regulation of acetylcholine secretion" EXACT []
synonym: "down-regulation of acetylcholine secretion" EXACT []
synonym: "downregulation of acetylcholine secretion" EXACT []
synonym: "inhibition of acetylcholine secretion" NARROW []
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051953 ! negative regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission
relationship: RO:0002212 GO:0014055 ! negatively regulates acetylcholine secretion, neurotransmission

[Term]
id: GO:0014059
name: regulation of dopamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]
is_a: GO:0050433 ! regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014046 ! regulates dopamine secretion
relationship: RO:0002211 GO:0014046 ! regulates dopamine secretion

[Term]
id: GO:0014061
name: regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef]
synonym: "regulation of noradrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048243 ! regulates norepinephrine secretion
relationship: RO:0002211 GO:0048243 ! regulates norepinephrine secretion

[Term]
id: GO:0014062
name: regulation of serotonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001820 ! regulates serotonin secretion
relationship: RO:0002211 GO:0001820 ! regulates serotonin secretion

[Term]
id: GO:0014063
name: negative regulation of serotonin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "down regulation of serotonin secretion" EXACT []
synonym: "down-regulation of serotonin secretion" EXACT []
synonym: "downregulation of serotonin secretion" EXACT []
synonym: "inhibition of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion
relationship: RO:0002212 GO:0001820 ! negatively regulates serotonin secretion

[Term]
id: GO:0014064
name: positive regulation of serotonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "activation of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
synonym: "stimulation of serotonin secretion" NARROW []
synonym: "up regulation of serotonin secretion" EXACT []
synonym: "up-regulation of serotonin secretion" EXACT []
synonym: "upregulation of serotonin secretion" EXACT []
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001820 ! positively regulates serotonin secretion
relationship: RO:0002213 GO:0001820 ! positively regulates serotonin secretion

[Term]
id: GO:0014075
name: response to amine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef]
synonym: "response to amine stimulus" EXACT [GOC:dos]
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine

[Term]
id: GO:0014706
name: striated muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]
is_a: GO:0060537 ! muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue
relationship: RO:0002296 UBERON:0002036 ! results in development of striated muscle tissue

[Term]
id: GO:0014733
name: regulation of skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation
relationship: RO:0002211 GO:0043501 ! regulates skeletal muscle adaptation

[Term]
id: GO:0014734
name: skeletal muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014897 ! striated muscle hypertrophy
is_a: GO:0043501 ! skeletal muscle adaptation
intersection_of: GO:0014896 ! muscle hypertrophy
intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue

[Term]
id: GO:0014741
name: negative regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy
relationship: RO:0002212 GO:0014896 ! negatively regulates muscle hypertrophy

[Term]
id: GO:0014742
name: positive regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy
relationship: RO:0002213 GO:0014896 ! positively regulates muscle hypertrophy

[Term]
id: GO:0014743
name: regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014896 ! regulates muscle hypertrophy
relationship: RO:0002211 GO:0014896 ! regulates muscle hypertrophy

[Term]
id: GO:0014744
name: positive regulation of muscle adaptation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "positive regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043500 ! positively regulates muscle adaptation
relationship: RO:0002213 GO:0043500 ! positively regulates muscle adaptation

[Term]
id: GO:0014745
name: negative regulation of muscle adaptation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "negative regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation
relationship: RO:0002212 GO:0043500 ! negatively regulates muscle adaptation

[Term]
id: GO:0014805
name: smooth muscle adaptation
namespace: biological_process
def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "smooth muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue
relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue

[Term]
id: GO:0014807
name: regulation of somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001756 ! regulates somitogenesis
relationship: RO:0002211 GO:0001756 ! regulates somitogenesis

[Term]
id: GO:0014812
name: muscle cell migration
namespace: biological_process
def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000187 ! results in movement of muscle cell
relationship: RO:0002565 CL:0000187 ! results in movement of muscle cell

[Term]
id: GO:0014819
name: regulation of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0006942 ! regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction
relationship: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction

[Term]
id: GO:0014852
name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014855
name: striated muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle]
is_a: GO:0033002 ! muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000737 ! acts on population of striated muscle cell
relationship: RO:0012003 CL:0000737 ! acts on population of striated muscle cell

[Term]
id: GO:0014856
name: skeletal muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0014855 ! striated muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle
relationship: RO:0012003 CL:0000188 ! acts on population of cell of skeletal muscle

[Term]
id: GO:0014857
name: regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation
relationship: RO:0002211 GO:0014856 ! regulates skeletal muscle cell proliferation

[Term]
id: GO:0014858
name: positive regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation
relationship: RO:0002213 GO:0014856 ! positively regulates skeletal muscle cell proliferation

[Term]
id: GO:0014859
name: negative regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation
relationship: RO:0002212 GO:0014856 ! negatively regulates skeletal muscle cell proliferation

[Term]
id: GO:0014860
name: neurotransmitter secretion involved in regulation of skeletal muscle contraction
namespace: biological_process
def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb]
synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007269 ! neurotransmitter secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: BFO:0000050 GO:0014819 ! part of regulation of skeletal muscle contraction
relationship: BFO:0000050 GO:0014852 ! part of regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014861
name: regulation of skeletal muscle contraction via regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED []
is_a: GO:0014819 ! regulation of skeletal muscle contraction
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential
relationship: RO:0002211 GO:0100001 ! regulates regulation of skeletal muscle contraction by action potential

[Term]
id: GO:0014866
name: skeletal myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0030239 ! myofibril assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril
relationship: RO:0002588 GO:0098723 ! results in assembly of skeletal muscle myofibril

[Term]
id: GO:0014872
name: myoblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle]
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000056 ! has primary input myoblast
relationship: RO:0004009 CL:0000056 ! has primary input myoblast

[Term]
id: GO:0014874
name: response to stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0050896 ! response to stimulus
intersection_of: GO:0050896 ! response to stimulus
intersection_of: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation
relationship: BFO:0000050 GO:0043502 ! part of regulation of muscle adaptation

[Term]
id: GO:0014887
name: cardiac muscle adaptation
namespace: biological_process
def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle]
synonym: "cardiac muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue
relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue

[Term]
id: GO:0014888
name: striated muscle adaptation
namespace: biological_process
def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "striated muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue
relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue

[Term]
id: GO:0014895
name: smooth muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014896 ! muscle hypertrophy
intersection_of: GO:0014896 ! muscle hypertrophy
intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue

[Term]
id: GO:0014896
name: muscle hypertrophy
namespace: biological_process
def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
xref: Wikipedia:Muscle_hypertrophy
is_a: GO:0003012 ! muscle system process
relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue

[Term]
id: GO:0014897
name: striated muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014896 ! muscle hypertrophy
intersection_of: GO:0014896 ! muscle hypertrophy
intersection_of: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue
relationship: RO:0004009 UBERON:0002036 ! has primary input striated muscle tissue

[Term]
id: GO:0014902
name: myotube differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0051146 ! striated muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002372 ! results in acquisition of features of myotube
relationship: RO:0002315 CL:0002372 ! results in acquisition of features of myotube

[Term]
id: GO:0014904
name: myotube cell development
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0055002 ! striated muscle cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0002372 ! results in development of myotube
relationship: BFO:0000050 GO:0014902 ! part of myotube differentiation
relationship: RO:0002296 CL:0002372 ! results in development of myotube

[Term]
id: GO:0014909
name: smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell
relationship: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell

[Term]
id: GO:0014910
name: regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014909 ! regulates smooth muscle cell migration
relationship: RO:0002211 GO:0014909 ! regulates smooth muscle cell migration

[Term]
id: GO:0014911
name: positive regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014909 ! positively regulates smooth muscle cell migration
relationship: RO:0002213 GO:0014909 ! positively regulates smooth muscle cell migration

[Term]
id: GO:0014912
name: negative regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014909 ! negatively regulates smooth muscle cell migration
relationship: RO:0002212 GO:0014909 ! negatively regulates smooth muscle cell migration

[Term]
id: GO:0015031
name: protein transport
namespace: biological_process
alt_id: GO:0015831
def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_yeast
synonym: "enzyme transport" NARROW []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0015075
name: monoatomic ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
synonym: "ion transmembrane transporter activity" BROAD []
synonym: "ion transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion
relationship: BFO:0000050 GO:0034220 ! part of monoatomic ion transmembrane transport
relationship: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion

[Term]
id: GO:0015144
name: carbohydrate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
synonym: "carbohydrate transporter activity" RELATED []
synonym: "sugar transporter" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
relationship: BFO:0000050 GO:0034219 ! part of carbohydrate transmembrane transport
relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate

[Term]
id: GO:0015159
name: polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-9932121 "Unknown transporter exports CA to extracellular space"
xref: Reactome:R-HSA-9932466 "Bcs complex exports pEtN-cellulose"
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: BFO:0000050 GO:0015774 ! part of polysaccharide transport
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide

[Term]
id: GO:0015171
name: amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "amino acid permease activity" EXACT []
synonym: "amino acid transporter activity" BROAD []
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "general amino acid permease activity" RELATED []
synonym: "hydroxy/aromatic amino acid permease activity" RELATED []
xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes"
xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons"
xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine"
xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine"
xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol"
xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake"
xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids"
xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids"
xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine"
xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids"
xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine"
xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine"
xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine"
xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine"
xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine"
xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine"
xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane"
xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane"
xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine"
xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids"
xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate"
xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane"
xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine"
xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol"
xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane"
xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen"
xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol"
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: BFO:0000050 GO:0003333 ! part of amino acid transmembrane transport
relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0015172
name: acidic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "acidic amino acid transporter activity" BROAD []
xref: Reactome:R-HSA-372448 "SLC25A12,13 exchange L-Glu and L-Asp"
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: BFO:0000050 GO:0015800 ! part of acidic amino acid transport

[Term]
id: GO:0015175
name: neutral L-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "neutral amino acid transmembrane transporter activity" EXACT []
synonym: "neutral amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: BFO:0000050 GO:0015804 ! part of neutral amino acid transport

[Term]
id: GO:0015179
name: L-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-amino acid transporter activity" BROAD []
xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes"
xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol"
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
relationship: BFO:0000050 GO:1902475 ! part of L-alpha-amino acid transmembrane transport
relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion

[Term]
id: GO:0015185
name: gamma-aminobutyric acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "4-aminobutanoate transporter activity" EXACT []
synonym: "4-aminobutyrate transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "GABA transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:59888 ! has primary input
relationship: BFO:0000050 GO:0015812 ! part of gamma-aminobutyric acid transport
relationship: RO:0004009 CHEBI:59888 ! has primary input

[Term]
id: GO:0015187
name: glycine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "glycine transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
relationship: BFO:0000050 GO:0015816 ! part of glycine transport
relationship: RO:0004009 CHEBI:57305 ! has primary input

[Term]
id: GO:0015464
name: acetylcholine receptor activity
namespace: molecular_function
def: "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'.
is_a: GO:0004888 ! transmembrane signaling receptor activity
is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: BFO:0000050 GO:0007271 ! part of synaptic transmission, cholinergic
relationship: BFO:0000051 GO:0042166 ! has part acetylcholine binding
relationship: RO:0004009 CHEBI:15355 ! has primary input

[Term]
id: GO:0015629
name: actin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015630
name: microtubule cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015631
name: tubulin binding
namespace: molecular_function
def: "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0015669
name: gas transport
namespace: biological_process
def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0015671
name: oxygen transport
namespace: biological_process
def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
xref: Reactome:R-HSA-8981607 "Intracellular oxygen transport"
is_a: GO:0015669 ! gas transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:15379 ! has primary input
relationship: RO:0004009 CHEBI:15379 ! has primary input

[Term]
id: GO:0015695
name: organic cation transport
namespace: biological_process
def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:25697 ! has primary input organic cation
relationship: RO:0004009 CHEBI:25697 ! has primary input organic cation

[Term]
id: GO:0015698
name: inorganic anion transport
namespace: biological_process
def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:24834 ! has primary input inorganic anion
relationship: RO:0004009 CHEBI:24834 ! has primary input inorganic anion

[Term]
id: GO:0015711
name: organic anion transport
namespace: biological_process
def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:25696 ! has primary input organic anion
relationship: RO:0004009 CHEBI:25696 ! has primary input organic anion

[Term]
id: GO:0015718
name: monocarboxylic acid transport
namespace: biological_process
def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0046942 ! carboxylic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion
relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion

[Term]
id: GO:0015774
name: polysaccharide transport
namespace: biological_process
def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: BFO:0000050 GO:0033037 ! part of polysaccharide localization
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide

[Term]
id: GO:0015800
name: acidic amino acid transport
namespace: biological_process
def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015804
name: neutral amino acid transport
namespace: biological_process
def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015807
name: L-amino acid transport
namespace: biological_process
def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion

[Term]
id: GO:0015812
name: gamma-aminobutyric acid transport
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]
comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'.
synonym: "4-aminobutanoate transport" EXACT []
synonym: "4-aminobutyrate transport" EXACT []
synonym: "GABA transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:59888 ! has primary input
relationship: RO:0004009 CHEBI:59888 ! has primary input

[Term]
id: GO:0015813
name: L-glutamate transmembrane transport
namespace: biological_process
def: "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]
synonym: "L-glutamate transport" BROAD []
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0051938 ! L-glutamate import
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
intersection_of: GO:0015800 ! acidic amino acid transport
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:29985 ! has primary input

[Term]
id: GO:0015816
name: glycine transport
namespace: biological_process
def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
relationship: RO:0004009 CHEBI:57305 ! has primary input

[Term]
id: GO:0015833
name: peptide transport
namespace: biological_process
def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0042886 ! amide transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion

[Term]
id: GO:0015837
name: amine transport
namespace: biological_process
def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
synonym: "amine/polyamine transport" RELATED []
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine

[Term]
id: GO:0015844
name: monoamine transport
namespace: biological_process
def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:63534 ! has primary input
relationship: RO:0004009 CHEBI:63534 ! has primary input

[Term]
id: GO:0015849
name: organic acid transport
namespace: biological_process
def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid
relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid

[Term]
id: GO:0015850
name: organic hydroxy compound transport
namespace: biological_process
def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]
synonym: "organic alcohol transport" EXACT []
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:33822 ! has primary input organic hydroxy compound
relationship: RO:0004009 CHEBI:33822 ! has primary input organic hydroxy compound

[Term]
id: GO:0015851
name: nucleobase transport
namespace: biological_process
def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
synonym: "nucleobase transmembrane transport" EXACT [GOC:mah]
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase
relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase

[Term]
id: GO:0015870
name: acetylcholine transport
namespace: biological_process
def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901374 ! acetate ester transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: RO:0004009 CHEBI:15355 ! has primary input

[Term]
id: GO:0015872
name: dopamine transport
namespace: biological_process
def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
relationship: RO:0004009 CHEBI:59905 ! has primary input

[Term]
id: GO:0015874
name: norepinephrine transport
namespace: biological_process
def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732]
synonym: "levarterenol transport" EXACT []
synonym: "noradrenaline transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:72587 ! has primary input
relationship: RO:0004009 CHEBI:72587 ! has primary input

[Term]
id: GO:0015931
name: nucleobase-containing compound transport
namespace: biological_process
def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity
relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity

[Term]
id: GO:0015932
name: nucleobase-containing compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity
relationship: BFO:0000050 GO:0015931 ! part of nucleobase-containing compound transport
relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
alt_id: GO:0016021
alt_id: GO:0098589
alt_id: GO:0098805
def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "integral component of membrane" NARROW []
synonym: "integral to membrane" NARROW []
synonym: "membrane region" NARROW []
synonym: "region of membrane" NARROW []
synonym: "transmembrane" RELATED [GOC:mah]
synonym: "whole membrane" NARROW []
xref: Wikipedia:Biological_membrane
xref: Wikipedia:Transmembrane_protein
is_a: GO:0110165 ! cellular anatomical structure
disjoint_from: GO:0031012 ! extracellular matrix
creation_date: 2014-03-06T11:37:54Z

[Term]
id: GO:0016031
name: tRNA import into mitochondrion
namespace: biological_process
def: "The process in which a tRNA is transported from the cytosol into the mitochondrial matrix." [GOC:ma, PMID:10988073, PMID:11121736]
synonym: "cytoplasmic tRNA import into mitochondria" EXACT []
synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf]
synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT []
synonym: "cytoplasmic tRNA, mitochondrial import" EXACT []
synonym: "mitochondrial import of cytoplasmic tRNA" NARROW []
synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0035927 ! RNA import into mitochondrion
is_a: GO:0051031 ! tRNA transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
intersection_of: RO:0004009 CHEBI:17843 ! has primary input

[Term]
id: GO:0016042
name: lipid catabolic process
namespace: biological_process
alt_id: GO:0006724
alt_id: GO:0044240
def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
synonym: "lipid breakdown" EXACT []
synonym: "lipid catabolism" EXACT []
synonym: "lipid degradation" EXACT []
synonym: "lipolysis" EXACT []
synonym: "multicellular organism lipid catabolic process" NARROW []
synonym: "multicellular organismal lipid catabolic process" NARROW []
xref: Wikipedia:Lipid_catabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
alt_id: GO:0044235
alt_id: GO:0071842
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
synonym: "cellular component organisation at cellular level" EXACT [GOC:mah]
synonym: "cellular component organisation in other organism" EXACT [GOC:mah]
synonym: "cellular component organization at cellular level" EXACT []
synonym: "cellular component organization in other organism" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002592 GO:0005575 ! results in organization of cellular_component
relationship: RO:0002592 GO:0005575 ! results in organization of cellular_component

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_plant
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
synonym: "non-developmental cell growth" RELATED [GOC:mah]
synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0040007 ! growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 CL:0000000 ! results in growth of cell
relationship: RO:0002343 CL:0000000 ! results in growth of cell

[Term]
id: GO:0016050
name: vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vesicle organisation" EXACT []
synonym: "vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0031982 ! results in organization of vesicle
relationship: RO:0002592 GO:0031982 ! results in organization of vesicle

[Term]
id: GO:0016051
name: carbohydrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
synonym: "anabolic carbohydrate metabolic process" EXACT []
synonym: "anabolic carbohydrate metabolism" EXACT []
synonym: "carbohydrate anabolism" EXACT []
synonym: "carbohydrate biosynthesis" EXACT []
synonym: "carbohydrate formation" EXACT []
synonym: "carbohydrate synthesis" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:16646 ! has primary output carbohydrate
relationship: RO:0004008 CHEBI:16646 ! has primary output carbohydrate

[Term]
id: GO:0016052
name: carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
synonym: "carbohydrate breakdown" EXACT []
synonym: "carbohydrate catabolism" EXACT []
synonym: "carbohydrate degradation" EXACT []
synonym: "catabolic carbohydrate metabolic process" EXACT []
synonym: "catabolic carbohydrate metabolism" EXACT []
synonym: "multicellular organismal carbohydrate catabolic process" NARROW []
synonym: "single-organism carbohydrate catabolic process" RELATED []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
creation_date: 2012-10-23T16:34:39Z

[Term]
id: GO:0016053
name: organic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
synonym: "organic acid anabolism" EXACT []
synonym: "organic acid biosynthesis" EXACT []
synonym: "organic acid formation" EXACT []
synonym: "organic acid synthesis" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:64709 ! has primary output organic acid
relationship: RO:0004008 CHEBI:64709 ! has primary output organic acid

[Term]
id: GO:0016054
name: organic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
synonym: "organic acid breakdown" EXACT []
synonym: "organic acid catabolism" EXACT []
synonym: "organic acid degradation" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044282 ! small molecule catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid
relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid

[Term]
id: GO:0016057
name: regulation of membrane potential in photoreceptor cell
namespace: biological_process
def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential
intersection_of: GO:0042391 ! regulation of membrane potential
intersection_of: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell
relationship: BFO:0000066 CL:0000210 ! occurs in photoreceptor cell

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
synonym: "RNA metabolism" EXACT []
xref: Reactome:R-HSA-8953854 "Metabolism of RNA"
is_a: GO:0090304 ! nucleic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33697 ! has primary input or output ribonucleic acid
relationship: RO:0004007 CHEBI:33697 ! has primary input or output ribonucleic acid

[Term]
id: GO:0016106
name: sesquiterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
synonym: "sesquiterpenoid anabolism" EXACT []
synonym: "sesquiterpenoid biosynthesis" EXACT []
synonym: "sesquiterpenoid formation" EXACT []
synonym: "sesquiterpenoid synthesis" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016114
name: terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
synonym: "terpenoid anabolism" EXACT []
synonym: "terpenoid biosynthesis" EXACT []
synonym: "terpenoid formation" EXACT []
synonym: "terpenoid synthesis" EXACT []
xref: Wikipedia:Terpenoid
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle
relationship: RO:0002608 GO:0031982 ! process has causal agent vesicle

[Term]
id: GO:0016202
name: regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014706 ! regulates striated muscle tissue development
relationship: RO:0002211 GO:0014706 ! regulates striated muscle tissue development

[Term]
id: GO:0016236
name: macroautophagy
namespace: biological_process
alt_id: GO:0034262
def: "The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]
synonym: "autophagy" BROAD []
synonym: "selective autophagy" NARROW []
xref: Reactome:R-HSA-1632852 "Macroautophagy"
xref: Reactome:R-HSA-5205685 "PINK1-PRKN Mediated Mitophagy"
xref: Reactome:R-HSA-8934903 "Receptor Mediated Mitophagy"
is_a: GO:0006914 ! autophagy
relationship: BFO:0000051 GO:0000045 ! has part autophagosome assembly

[Term]
id: GO:0016241
name: regulation of macroautophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]
synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016236 ! regulates macroautophagy
relationship: RO:0002211 GO:0016236 ! regulates macroautophagy

[Term]
id: GO:0016301
name: kinase activity
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
synonym: "phosphokinase activity" EXACT []
xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm"
xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016310
name: phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
subset: goslim_metagenomics
xref: Wikipedia:Phosphorylation
is_a: GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0016321
name: female meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
is_a: GO:0045132 ! meiotic chromosome segregation
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: BFO:0000050 GO:0007143 ! part of female meiotic nuclear division
relationship: BFO:0000050 GO:0007143 ! part of female meiotic nuclear division

[Term]
id: GO:0016325
name: oocyte microtubule cytoskeleton organization
namespace: biological_process
def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
synonym: "oocyte microtubule cytoskeleton organisation" EXACT []
is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity
intersection_of: GO:0016043 ! cellular component organization
intersection_of: BFO:0000066 CL:0000023 ! occurs in oocyte
intersection_of: RO:0002592 GO:0015630 ! results in organization of microtubule cytoskeleton
relationship: BFO:0000050 GO:0007308 ! part of oocyte construction
relationship: BFO:0000066 CL:0000023 ! occurs in oocyte

[Term]
id: GO:0016331
name: morphogenesis of embryonic epithelium
namespace: biological_process
def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0016358
name: dendrite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]
is_a: GO:0031175 ! neuron projection development
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 GO:0030425 ! results in development of dendrite
relationship: RO:0002296 GO:0030425 ! results in development of dendrite

[Term]
id: GO:0016462
name: pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]
xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP"
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0016477
name: cell migration
namespace: biological_process
def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
xref: Wikipedia:Cell_migration
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0016482
name: cytosolic transport
namespace: biological_process
def: "The directed movement of substances or organelles within the cytosol." [GOC:ai]
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
relationship: BFO:0000066 GO:0005829 ! occurs in cytosol

[Term]
id: GO:0016525
name: negative regulation of angiogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]
synonym: "down regulation of angiogenesis" EXACT []
synonym: "down-regulation of angiogenesis" EXACT []
synonym: "downregulation of angiogenesis" EXACT []
synonym: "inhibition of angiogenesis" NARROW []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001525 ! negatively regulates angiogenesis
relationship: RO:0002212 GO:0001525 ! negatively regulates angiogenesis

[Term]
id: GO:0016528
name: sarcoplasm
namespace: cellular_component
def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684]
xref: Wikipedia:Sarcoplasm
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell
relationship: BFO:0000050 CL:0000187 ! part of muscle cell

[Term]
id: GO:0016594
name: glycine binding
namespace: molecular_function
def: "Binding to glycine, aminoethanoic acid." [GOC:ai]
synonym: "aminoacetic acid binding" EXACT []
synonym: "aminoethanoic acid binding" EXACT []
synonym: "Gly binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043169 ! cation binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
relationship: RO:0004009 CHEBI:57305 ! has primary input

[Term]
id: GO:0016595
name: glutamate binding
namespace: molecular_function
def: "Binding to glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai]
synonym: "glutamic acid binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0031406 ! carboxylic acid binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:14321 ! has primary input
relationship: RO:0004009 CHEBI:14321 ! has primary input

[Term]
id: GO:0016597
name: amino acid binding
namespace: molecular_function
def: "Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
subset: goslim_metagenomics
subset: goslim_pir
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:2.-.-.-
xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2"
xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1"
xref: Reactome:R-HSA-5333607 "GSSeH combines with bGalNAc derivative to form GSSebGalNac"
xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK"
xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016746
name: acyltransferase activity
namespace: molecular_function
alt_id: GO:0008415
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [EC:2.3.-.-]
subset: goslim_chembl
subset: goslim_drosophila
synonym: "transferase activity, transferring acyl groups" EXACT []
xref: EC:2.3.-.-
xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate"
xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate"
xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016755
name: aminoacyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]
synonym: "transferase activity, transferring amino-acyl groups" EXACT []
xref: EC:2.3.2.-
is_a: GO:0016746 ! acyltransferase activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:3.-.-.-
xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes"
xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation"
xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE"
xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB"
xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS"
xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP"
xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP"
xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016798
name: hydrolase activity, acting on glycosyl bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "glycosidase activity" EXACT []
synonym: "glycosylase" NARROW []
synonym: "N-glycosylase" NARROW []
xref: EC:3.2.-.-
xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan"
xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016817
name: hydrolase activity, acting on acid anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW []
xref: EC:3.6.-.-
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016818
name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
xref: EC:3.6.1.-
xref: Reactome:R-HSA-9731590 "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP"
xref: Reactome:R-HSA-9731613 "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP"
xref: Reactome:R-HSA-9731632 "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP"
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "synthetase activity" EXACT [GOC:jh2]
xref: EC:6.-.-.-
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016877
name: ligase activity, forming carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.-.-]
synonym: "ligase activity, forming carbon-sulphur bonds" EXACT []
xref: EC:6.2.-.-
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016887
name: ATP hydrolysis activity
namespace: molecular_function
alt_id: GO:0004002
alt_id: GO:0042623
def: "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]
comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function.
synonym: "adenosine 5'-triphosphatase activity" EXACT []
synonym: "adenosine triphosphatase activity" EXACT []
synonym: "adenosinetriphosphatase activity" EXACT []
synonym: "ATP hydrolase activity" EXACT []
synonym: "ATP monophosphatase activity" RELATED []
synonym: "ATP phosphohydrolase activity" EXACT []
xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)"
xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70"
xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse"
xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90"
xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA"
xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE"
xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi"
xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER"
xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation"
xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN"
xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN"
xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane"
xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating"
xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex"
xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG"
xref: Reactome:R-HSA-917693 "ESCRT Disassembly"
xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP"
xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope"
xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP"
xref: Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex"
xref: RHEA:13065
is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity
relationship: BFO:0000050 GO:0140657 ! part of ATP-dependent activity

[Term]
id: GO:0016907
name: G protein-coupled acetylcholine receptor activity
namespace: molecular_function
def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled acetylcholine receptor activity" EXACT []
synonym: "G-protein coupled acetylcholine receptor activity" EXACT []
synonym: "metabotropic acetylcholine receptor activity" EXACT []
synonym: "muscarinic acetylcholine receptor activity" EXACT []
xref: Reactome:R-HSA-400012 "Acetylcholine binds Muscarinic Acetylcholine Receptor M3"
is_a: GO:0008227 ! G protein-coupled amine receptor activity
is_a: GO:0015464 ! acetylcholine receptor activity
is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
intersection_of: GO:0004930 ! G protein-coupled receptor activity
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: BFO:0000050 GO:0007213 ! part of G protein-coupled acetylcholine receptor signaling pathway

[Term]
id: GO:0016917
name: GABA receptor activity
namespace: molecular_function
def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650]
comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'.
synonym: "4-aminobutanoate receptor activity" EXACT []
synonym: "4-aminobutyrate receptor activity" EXACT []
synonym: "GABA binding" EXACT []
synonym: "gamma-aminobutyrate binding" EXACT []
synonym: "gamma-aminobutyric acid binding" EXACT []
synonym: "gamma-aminobutyric acid receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity
intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: RO:0004009 CHEBI:59888 ! has primary input
relationship: RO:0004009 CHEBI:59888 ! has primary input

[Term]
id: GO:0017046
name: peptide hormone binding
namespace: molecular_function
def: "Binding to a peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732]
synonym: "polypeptide hormone binding" EXACT []
is_a: GO:0033218 ! amide binding
is_a: GO:0042562 ! hormone binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:25905 ! has primary input
relationship: RO:0004009 CHEBI:25905 ! has primary input

[Term]
id: GO:0017111
name: ribonucleoside triphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]
subset: goslim_chembl
subset: goslim_metagenomics
synonym: "apyrase activity" BROAD []
synonym: "NTPase activity" EXACT []
synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15]
synonym: "nucleoside triphosphatase activity" BROAD []
synonym: "nucleoside triphosphate hydrolase activity" BROAD []
synonym: "nucleoside triphosphate phosphatase activity" BROAD []
synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED []
synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED []
synonym: "nucleoside-triphosphatase activity" BROAD []
xref: EC:3.6.1.15
xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN
xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates"
xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates"
xref: RHEA:23680
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017126
name: nucleologenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732]
synonym: "nucleolus assembly" NARROW [GOC:mah]
synonym: "nucleolus biogenesis" EXACT []
is_a: GO:0007000 ! nucleolus organization
is_a: GO:0044085 ! cellular component biogenesis
intersection_of: GO:0044085 ! cellular component biogenesis
intersection_of: RO:0004008 GO:0005730 ! has primary output nucleolus
relationship: RO:0004008 GO:0005730 ! has primary output nucleolus

[Term]
id: GO:0017145
name: stem cell division
namespace: biological_process
def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]
synonym: "stem cell renewal" EXACT []
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell
relationship: RO:0004009 CL:0000034 ! has primary input stem cell

[Term]
id: GO:0017148
name: negative regulation of translation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]
synonym: "down regulation of protein biosynthetic process" EXACT []
synonym: "down-regulation of protein biosynthetic process" EXACT []
synonym: "downregulation of protein biosynthetic process" EXACT []
synonym: "inhibition of protein biosynthetic process" NARROW []
synonym: "negative regulation of protein anabolism" EXACT []
synonym: "negative regulation of protein biosynthesis" EXACT []
synonym: "negative regulation of protein biosynthetic process" EXACT []
synonym: "negative regulation of protein formation" EXACT []
synonym: "negative regulation of protein synthesis" EXACT []
synonym: "protein biosynthesis inhibitor activity" RELATED []
synonym: "protein biosynthetic process inhibitor activity" RELATED []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation
relationship: RO:0002212 GO:0006412 ! negatively regulates translation

[Term]
id: GO:0017157
name: regulation of exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006887 ! regulates exocytosis
relationship: RO:0002211 GO:0006887 ! regulates exocytosis

[Term]
id: GO:0018958
name: phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]
comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.
synonym: "carbolic acid metabolic process" EXACT []
synonym: "carbolic acid metabolism" EXACT []
synonym: "hydroxybenzene metabolic process" EXACT []
synonym: "hydroxybenzene metabolism" EXACT []
synonym: "phenol-containing compound metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33853 ! has primary input or output phenols
relationship: RO:0004007 CHEBI:33853 ! has primary input or output phenols

[Term]
id: GO:0018995
name: host cellular component
namespace: cellular_component
def: "Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732]
synonym: "host organism" EXACT []
xref: Wikipedia:Host_(biology)
is_a: GO:0044217 ! other organism part

[Term]
id: GO:0019093
name: mitochondrial RNA localization
namespace: biological_process
def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT []
synonym: "mitochondrial RNA localisation" EXACT [GOC:mah]
synonym: "mtRNA localization" EXACT []
is_a: GO:0006403 ! RNA localization
intersection_of: GO:0006403 ! RNA localization
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0019098
name: reproductive behavior
namespace: biological_process
def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr]
synonym: "multi-organism reproductive behavior" NARROW []
synonym: "multicellular organism reproductive behavior" NARROW []
synonym: "reproductive behavior in a multicellular organism" EXACT []
synonym: "reproductive behaviour" EXACT []
synonym: "single-organism reproductive behavior" RELATED []
is_a: GO:0007610 ! behavior
is_a: GO:0048609 ! multicellular organismal reproductive process
intersection_of: GO:0007610 ! behavior
intersection_of: GO:0048609 ! multicellular organismal reproductive process
creation_date: 2012-09-19T16:01:37Z

[Term]
id: GO:0019216
name: regulation of lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "regulation of lipid metabolism" EXACT []
xref: Reactome:R-HSA-2426168 "Activation of gene expression by SREBF (SREBP)"
xref: Reactome:R-HSA-400206 "Regulation of lipid metabolism by PPARalpha"
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006629 ! regulates lipid metabolic process
relationship: RO:0002211 GO:0006629 ! regulates lipid metabolic process

[Term]
id: GO:0019218
name: regulation of steroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "regulation of steroid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008202 ! regulates steroid metabolic process
relationship: RO:0002211 GO:0008202 ! regulates steroid metabolic process

[Term]
id: GO:0019219
name: regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process
relationship: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process

[Term]
id: GO:0019221
name: cytokine-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]
synonym: "cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "cytokine mediated signalling pathway" EXACT []
xref: Reactome:R-HSA-449147 "Signaling by Interleukins"
xref: Reactome:R-HSA-913531 "Interferon Signaling"
xref: Reactome:R-HSA-9607240 "FLT3 Signaling"
xref: Reactome:R-HSA-9674555 "Signaling by CSF3 (G-CSF)"
xref: Reactome:R-HSA-9680350 "Signaling by CSF1 (M-CSF) in myeloid cells"
is_a: GO:0007166 ! cell surface receptor signaling pathway
relationship: BFO:0000050 GO:0071345 ! part of cellular response to cytokine stimulus

[Term]
id: GO:0019222
name: regulation of metabolic process
namespace: biological_process
alt_id: GO:0044246
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
synonym: "regulation of metabolism" EXACT []
synonym: "regulation of multicellular organismal metabolic process" NARROW []
synonym: "regulation of organismal metabolic process" NARROW [GOC:tb]
xref: Reactome:R-HSA-1989781 "PPARA activates gene expression"
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008152 ! regulates metabolic process
relationship: RO:0002211 GO:0008152 ! regulates metabolic process

[Term]
id: GO:0019226
name: transmission of nerve impulse
namespace: biological_process
def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194]
synonym: "conduction of nerve impulse" EXACT [GOC:dph]
synonym: "signal transmission along a neuron" EXACT []
is_a: GO:0050877 ! nervous system process
relationship: BFO:0000050 GO:0007154 ! part of cell communication
relationship: BFO:0000051 GO:0001508 ! has part action potential
relationship: BFO:0000051 GO:0007268 ! has part chemical synaptic transmission

[Term]
id: GO:0019228
name: neuronal action potential
namespace: biological_process
def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001508 ! action potential
intersection_of: GO:0001508 ! action potential
intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron
relationship: BFO:0000050 GO:0019226 ! part of transmission of nerve impulse
relationship: BFO:0000066 CL:0000540 ! occurs in neuron

[Term]
id: GO:0019233
name: sensory perception of pain
namespace: biological_process
def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system." [GOC:curators]
synonym: "nociception" RELATED []
synonym: "perception of physiological pain" NARROW []
xref: Wikipedia:Nociception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0019336
name: phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]
synonym: "phenol-containing compound breakdown" EXACT []
synonym: "phenol-containing compound catabolism" EXACT []
synonym: "phenol-containing compound degradation" EXACT []
xref: MetaCyc:PHENOLDEG-PWY
is_a: GO:0009056 ! catabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33853 ! has primary input phenols
relationship: RO:0004009 CHEBI:33853 ! has primary input phenols

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
alt_id: GO:0044267
alt_id: GO:0044268
def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "cellular protein metabolic process" EXACT []
synonym: "cellular protein metabolism" EXACT []
synonym: "multicellular organismal protein metabolic process" NARROW []
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Reactome:R-HSA-392499 "Metabolism of proteins"
xref: Wikipedia:Protein_metabolism
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 PR:000000001 ! has primary input or output protein
relationship: RO:0004007 PR:000000001 ! has primary input or output protein

[Term]
id: GO:0019614
name: catechol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
synonym: "catechol breakdown" RELATED []
synonym: "catechol catabolic process" RELATED []
synonym: "catechol catabolism" RELATED []
synonym: "catechol degradation" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33566 ! has primary input
relationship: RO:0004009 CHEBI:33566 ! has primary input

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_candida
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_plant
is_a: GO:0042592 ! homeostatic process
intersection_of: GO:0042592 ! homeostatic process
intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
disjoint_from: GO:0048872 ! homeostasis of number of cells
relationship: BFO:0000066 CL:0000000 ! occurs in cell
relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms

[Term]
id: GO:0019747
name: regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators]
synonym: "regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006720 ! regulates isoprenoid metabolic process
relationship: RO:0002211 GO:0006720 ! regulates isoprenoid metabolic process

[Term]
id: GO:0019748
name: secondary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_pombe
synonym: "secondary metabolism" EXACT []
synonym: "secondary metabolite metabolic process" EXACT []
synonym: "secondary metabolite metabolism" EXACT []
xref: Wikipedia:Secondary_metabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019750
name: chloroplast localization
namespace: biological_process
def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732]
synonym: "chloroplast localisation" EXACT [GOC:mah]
is_a: GO:0051644 ! plastid localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0009507 ! has primary input chloroplast
relationship: RO:0004009 GO:0009507 ! has primary input chloroplast

[Term]
id: GO:0019751
name: polyol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [PMID:30240188]
synonym: "polyhydric alcohol metabolic process" EXACT []
synonym: "polyol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0019752
name: carboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
synonym: "carboxylic acid metabolism" EXACT []
xref: Reactome:R-HSA-389661 "Glyoxylate metabolism and glycine degradation"
is_a: GO:0043436 ! oxoacid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:29067 ! has primary input or output carboxylic acid anion
relationship: RO:0004007 CHEBI:29067 ! has primary input or output carboxylic acid anion

[Term]
id: GO:0019755
name: one-carbon compound transport
namespace: biological_process
def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "one carbon compound transport" EXACT []
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:64708 ! has primary input one-carbon compound
relationship: RO:0004009 CHEBI:64708 ! has primary input one-carbon compound

[Term]
id: GO:0019777
name: Atg12 transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404]
synonym: "APG12 conjugating enzyme activity" NARROW []
synonym: "APG12 ligase activity" NARROW []
synonym: "Atg12 conjugating enzyme activity" NARROW []
synonym: "Atg12 ligase activity" NARROW []
xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10"
is_a: GO:0019787 ! ubiquitin-like protein transferase activity

[Term]
id: GO:0019778
name: Atg12 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "APG12 activating enzyme activity" RELATED [GOC:vw]
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity

[Term]
id: GO:0019786
name: protein-phosphatidylethanolamide deconjugating activity
namespace: molecular_function
def: "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]
synonym: "APG8-PE hydrolase" RELATED []
synonym: "APG8-specific protease activity" NARROW [GOC:vw]
synonym: "ATG8-PE deconjugation activity" NARROW []
synonym: "ATG8-PE hydrolase activity" NARROW []
synonym: "Atg8-specific peptidase activity" NARROW []
synonym: "Atg8-specific protease activity" EXACT []
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0019787
name: ubiquitin-like protein transferase activity
namespace: molecular_function
alt_id: GO:0008639
alt_id: GO:0008640
def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]
subset: goslim_drosophila
subset: goslim_pir
synonym: "E2" BROAD []
synonym: "E3" RELATED [GOC:dph]
synonym: "small conjugating protein ligase activity" NARROW [GOC:dph]
synonym: "small conjugating protein transferase activity" EXACT [GOC:dph]
synonym: "small protein conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like-protein ligase activity" NARROW []
xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE"
xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated"
is_a: GO:0016755 ! aminoacyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein

[Term]
id: GO:0019825
name: oxygen binding
namespace: molecular_function
def: "Binding to oxygen (O2)." [GOC:jl]
subset: goslim_pir
subset: goslim_plant
synonym: "cytochrome P450" NARROW []
synonym: "cytochrome P450 activity" RELATED []
is_a: GO:0036094 ! small molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:15379 ! has primary input
relationship: RO:0004009 CHEBI:15379 ! has primary input

[Term]
id: GO:0019835
name: cytolysis
namespace: biological_process
def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]
subset: goslim_chembl
synonym: "autolysin activity" RELATED []
synonym: "bacteriocin activity" RELATED []
synonym: "bacteriolytic toxin activity" RELATED []
synonym: "holin" RELATED []
synonym: "lysin activity" RELATED []
synonym: "lysis" BROAD []
synonym: "necrosis" RELATED []
xref: Wikipedia:Cytolysis
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0019867
name: outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
subset: goslim_metagenomics
is_a: GO:0016020 ! membrane

[Term]
id: GO:0019882
name: antigen processing and presentation
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation" EXACT []
synonym: "antigen processing" EXACT []
xref: Wikipedia:Antigen_presentation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0019896
name: axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
subset: goslim_synapse
synonym: "axon transport of mitochondria" EXACT []
is_a: GO:0047497 ! mitochondrion transport along microtubule
is_a: GO:0098930 ! axonal transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion
relationship: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm

[Term]
id: GO:0019953
name: sexual reproduction
namespace: biological_process
def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction]
comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.
subset: gocheck_do_not_annotate
xref: Wikipedia:Sexual_reproduction
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0019954
name: asexual reproduction
namespace: biological_process
def: "A type of reproduction in which new individuals are produced from a single organism, either from an unfertilized egg or from a single cell or group of cells." [ISBN:0387520546, PMID:22977071, PMID:28779329, PMID:29559496]
synonym: "parthenogenesis" RELATED [Wikipedia:Parthenogenesis]
xref: Wikipedia:Asexual_reproduction
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0019955
name: cytokine binding
namespace: molecular_function
def: "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
synonym: "IL binding" NARROW []
synonym: "interleukin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0021501
name: prechordal plate formation
namespace: biological_process
def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003063 ! results in formation of prechordal plate
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002297 UBERON:0003063 ! results in formation of prechordal plate

[Term]
id: GO:0021508
name: floor plate formation
namespace: biological_process
def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003079 ! results in formation of floor plate
relationship: BFO:0000050 GO:0007418 ! part of ventral midline development
relationship: BFO:0000050 GO:0033505 ! part of floor plate morphogenesis
relationship: RO:0002297 UBERON:0003079 ! results in formation of floor plate

[Term]
id: GO:0021510
name: spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002240 ! results in development of spinal cord
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002296 UBERON:0002240 ! results in development of spinal cord

[Term]
id: GO:0021514
name: ventral spinal cord interneuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord
intersection_of: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron
relationship: BFO:0000050 GO:0021517 ! part of ventral spinal cord development
relationship: RO:0002315 CL:0000099 ! results in acquisition of features of interneuron

[Term]
id: GO:0021515
name: cell differentiation in spinal cord
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord
relationship: BFO:0000050 GO:0021510 ! part of spinal cord development
relationship: BFO:0000066 UBERON:0002240 ! occurs in spinal cord

[Term]
id: GO:0021517
name: ventral spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord
relationship: BFO:0000050 GO:0021510 ! part of spinal cord development
relationship: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord

[Term]
id: GO:0021522
name: spinal cord motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron
relationship: BFO:0000050 GO:0021517 ! part of ventral spinal cord development
relationship: RO:0002315 CL:0011001 ! results in acquisition of features of spinal cord motor neuron

[Term]
id: GO:0021523
name: somatic motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021522 ! spinal cord motor neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron
relationship: RO:0002315 CL:0005024 ! results in acquisition of features of somatomotor neuron

[Term]
id: GO:0021531
name: spinal cord radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16185248]
synonym: "radial glial cell differentiation in spinal cord" EXACT []
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0060019 ! radial glial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000073 ! results in acquisition of features of spinal cord radial glial cell
relationship: RO:0002315 CL:1000073 ! results in acquisition of features of spinal cord radial glial cell

[Term]
id: GO:0021532
name: neural tube patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0003002 ! regionalization
relationship: BFO:0000050 GO:0021915 ! part of neural tube development

[Term]
id: GO:0021533
name: cell differentiation in hindbrain
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain

[Term]
id: GO:0021534
name: cell proliferation in hindbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain

[Term]
id: GO:0021535
name: cell migration in hindbrain
namespace: biological_process
def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: BFO:0000066 UBERON:0002028 ! occurs in hindbrain

[Term]
id: GO:0021536
name: diencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001894 ! results in development of diencephalon
relationship: BFO:0000050 GO:0030900 ! part of forebrain development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002296 UBERON:0001894 ! results in development of diencephalon

[Term]
id: GO:0021537
name: telencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001893 ! results in development of telencephalon
relationship: BFO:0000050 GO:0030900 ! part of forebrain development
relationship: RO:0002296 UBERON:0001893 ! results in development of telencephalon

[Term]
id: GO:0021538
name: epithalamus development
namespace: biological_process
def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001899 ! results in development of epithalamus
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: RO:0002296 UBERON:0001899 ! results in development of epithalamus

[Term]
id: GO:0021543
name: pallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000203 ! results in development of pallium
relationship: BFO:0000050 GO:0021537 ! part of telencephalon development
relationship: RO:0002296 UBERON:0000203 ! results in development of pallium

[Term]
id: GO:0021544
name: subpallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000204 ! results in development of ventral part of telencephalon
relationship: BFO:0000050 GO:0021537 ! part of telencephalon development
relationship: RO:0002296 UBERON:0000204 ! results in development of ventral part of telencephalon

[Term]
id: GO:0021545
name: cranial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021675 ! nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001785 ! results in development of cranial nerve
relationship: RO:0002296 UBERON:0001785 ! results in development of cranial nerve

[Term]
id: GO:0021546
name: rhombomere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001892 ! results in development of rhombomere
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: RO:0002296 UBERON:0001892 ! results in development of rhombomere

[Term]
id: GO:0021547
name: midbrain-hindbrain boundary initiation
namespace: biological_process
def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513]
synonym: "isthmus biosynthesis" RELATED [GOC:cls]
synonym: "isthmus formation" RELATED [GOC:cls]
synonym: "MHB biosynthesis" EXACT [GOC:cls]
synonym: "MHB formation" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls]
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003052 ! results in formation of midbrain-hindbrain boundary
relationship: BFO:0000050 GO:0021999 ! part of neural plate anterior/posterior regionalization
relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development
relationship: RO:0002297 UBERON:0003052 ! results in formation of midbrain-hindbrain boundary

[Term]
id: GO:0021548
name: pons development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000988 ! results in development of pons
relationship: BFO:0000050 GO:0022037 ! part of metencephalon development
relationship: RO:0002296 UBERON:0000988 ! results in development of pons

[Term]
id: GO:0021549
name: cerebellum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002037 ! results in development of cerebellum
relationship: BFO:0000050 GO:0022037 ! part of metencephalon development
relationship: RO:0002296 UBERON:0002037 ! results in development of cerebellum

[Term]
id: GO:0021550
name: medulla oblongata development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla development" RELATED [GOC:cls]
synonym: "myelencephalon development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: RO:0002296 UBERON:0001896 ! results in development of medulla oblongata

[Term]
id: GO:0021551
name: central nervous system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002298 UBERON:0001017 ! results in morphogenesis of central nervous system

[Term]
id: GO:0021555
name: midbrain-hindbrain boundary morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus morphogenesis" EXACT [GOC:cls]
synonym: "MHB morphogenesis" EXACT [GOC:cls]
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary
relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development
relationship: RO:0002298 UBERON:0003052 ! results in morphogenesis of midbrain-hindbrain boundary

[Term]
id: GO:0021556
name: central nervous system formation
namespace: biological_process
def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001017 ! results in formation of central nervous system
relationship: BFO:0000050 GO:0021551 ! part of central nervous system morphogenesis
relationship: RO:0002297 UBERON:0001017 ! results in formation of central nervous system

[Term]
id: GO:0021559
name: trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V development" RELATED [GOC:cls]
synonym: "cranial nerve 5 development" EXACT [GOC:cls]
synonym: "cranial nerve V development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve
relationship: RO:0002296 UBERON:0001645 ! results in development of trigeminal nerve

[Term]
id: GO:0021563
name: glossopharyngeal nerve development
namespace: biological_process
def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX development" RELATED [GOC:cls]
synonym: "cranial nerve 9 development" EXACT [GOC:cls]
synonym: "cranial nerve IX development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001649 ! results in development of glossopharyngeal nerve
relationship: RO:0002296 UBERON:0001649 ! results in development of glossopharyngeal nerve

[Term]
id: GO:0021564
name: vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X development" RELATED [GOC:cls]
synonym: "cranial nerve 10 development" RELATED [GOC:cls]
synonym: "cranial nerve X development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001759 ! results in development of vagus nerve
relationship: BFO:0000050 GO:0021783 ! part of preganglionic parasympathetic fiber development
relationship: RO:0002296 UBERON:0001759 ! results in development of vagus nerve

[Term]
id: GO:0021565
name: accessory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI development" RELATED [GOC:cls]
synonym: "cranial nerve 11 development" RELATED [GOC:cls]
synonym: "cranial nerve XI development" EXACT [GOC:cls]
synonym: "spinal accessory nerve development" EXACT [PMID:11533729]
is_a: GO:0021545 ! cranial nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002019 ! results in development of accessory XI nerve
relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda
relationship: RO:0002296 UBERON:0002019 ! results in development of accessory XI nerve

[Term]
id: GO:0021566
name: hypoglossal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII development" RELATED [GOC:cls]
synonym: "cranial nerve 12 development" RELATED [GOC:cls]
synonym: "cranial nerve XII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001650 ! results in development of hypoglossal nerve
relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda
relationship: RO:0002296 UBERON:0001650 ! results in development of hypoglossal nerve

[Term]
id: GO:0021567
name: rhombomere 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021546 ! rhombomere development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005499 ! results in development of rhombomere 1
relationship: RO:0002296 UBERON:0005499 ! results in development of rhombomere 1

[Term]
id: GO:0021575
name: hindbrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "rhombencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: RO:0002298 UBERON:0002028 ! results in morphogenesis of hindbrain

[Term]
id: GO:0021576
name: hindbrain formation
namespace: biological_process
def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002028 ! results in formation of hindbrain
relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis
relationship: RO:0002297 UBERON:0002028 ! results in formation of hindbrain

[Term]
id: GO:0021578
name: hindbrain maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain
relationship: BFO:0000050 GO:0021626 ! part of central nervous system maturation
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: RO:0002299 UBERON:0002028 ! results in maturation of hindbrain

[Term]
id: GO:0021579
name: medulla oblongata morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla morphogenesis" RELATED []
synonym: "myelencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata
relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development
relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis
relationship: RO:0002298 UBERON:0001896 ! results in morphogenesis of medulla oblongata

[Term]
id: GO:0021580
name: medulla oblongata formation
namespace: biological_process
def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla biosynthesis" RELATED []
synonym: "medulla formation" RELATED []
synonym: "myelencephalon biosynthesis" RELATED []
synonym: "myelencephalon formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001896 ! results in formation of medulla oblongata
relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation
relationship: BFO:0000050 GO:0021579 ! part of medulla oblongata morphogenesis
relationship: RO:0002297 UBERON:0001896 ! results in formation of medulla oblongata

[Term]
id: GO:0021582
name: medulla oblongata maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla maturation" RELATED []
synonym: "myelencephalon maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata
relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development
relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation
relationship: RO:0002299 UBERON:0001896 ! results in maturation of medulla oblongata

[Term]
id: GO:0021583
name: pons morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons
relationship: BFO:0000050 GO:0021548 ! part of pons development
relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis
relationship: RO:0002298 UBERON:0000988 ! results in morphogenesis of pons

[Term]
id: GO:0021584
name: pons formation
namespace: biological_process
def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000988 ! results in formation of pons
relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation
relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis
relationship: RO:0002297 UBERON:0000988 ! results in formation of pons

[Term]
id: GO:0021586
name: pons maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0000988 ! results in maturation of pons
relationship: BFO:0000050 GO:0021548 ! part of pons development
relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation
relationship: RO:0002299 UBERON:0000988 ! results in maturation of pons

[Term]
id: GO:0021587
name: cerebellum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002037 ! results in morphogenesis of cerebellum
relationship: BFO:0000050 GO:0021549 ! part of cerebellum development
relationship: BFO:0000050 GO:0021575 ! part of hindbrain morphogenesis
relationship: RO:0002298 UBERON:0002037 ! results in morphogenesis of cerebellum

[Term]
id: GO:0021588
name: cerebellum formation
namespace: biological_process
def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002037 ! results in formation of cerebellum
relationship: BFO:0000050 GO:0021576 ! part of hindbrain formation
relationship: BFO:0000050 GO:0021587 ! part of cerebellum morphogenesis
relationship: RO:0002297 UBERON:0002037 ! results in formation of cerebellum

[Term]
id: GO:0021590
name: cerebellum maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002037 ! results in maturation of cerebellum
relationship: BFO:0000050 GO:0021549 ! part of cerebellum development
relationship: BFO:0000050 GO:0021578 ! part of hindbrain maturation
relationship: RO:0002299 UBERON:0002037 ! results in maturation of cerebellum

[Term]
id: GO:0021591
name: ventricular system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005281 ! results in development of ventricular system of central nervous system
relationship: BFO:0000050 GO:0007420 ! part of brain development
relationship: RO:0002296 UBERON:0005281 ! results in development of ventricular system of central nervous system

[Term]
id: GO:0021592
name: fourth ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002422 ! results in development of fourth ventricle
relationship: BFO:0000050 GO:0021591 ! part of ventricular system development
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: RO:0002296 UBERON:0002422 ! results in development of fourth ventricle

[Term]
id: GO:0021593
name: rhombomere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere
relationship: BFO:0000050 GO:0021546 ! part of rhombomere development
relationship: RO:0002298 UBERON:0001892 ! results in morphogenesis of rhombomere

[Term]
id: GO:0021594
name: rhombomere formation
namespace: biological_process
def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001892 ! results in formation of rhombomere
relationship: BFO:0000050 GO:0021593 ! part of rhombomere morphogenesis
relationship: RO:0002297 UBERON:0001892 ! results in formation of rhombomere

[Term]
id: GO:0021602
name: cranial nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve
relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development
relationship: RO:0002298 UBERON:0001785 ! results in morphogenesis of cranial nerve

[Term]
id: GO:0021603
name: cranial nerve formation
namespace: biological_process
def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001785 ! results in formation of cranial nerve
relationship: BFO:0000050 GO:0021602 ! part of cranial nerve morphogenesis
relationship: RO:0002297 UBERON:0001785 ! results in formation of cranial nerve

[Term]
id: GO:0021605
name: cranial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021682 ! nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve
relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development
relationship: RO:0002299 UBERON:0001785 ! results in maturation of cranial nerve

[Term]
id: GO:0021606
name: accessory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI maturation" RELATED []
synonym: "spinal accessory nerve maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002019 ! results in maturation of accessory XI nerve
relationship: BFO:0000050 GO:0021565 ! part of accessory nerve development
relationship: RO:0002299 UBERON:0002019 ! results in maturation of accessory XI nerve

[Term]
id: GO:0021607
name: accessory nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002019 ! results in morphogenesis of accessory XI nerve
relationship: BFO:0000050 GO:0021565 ! part of accessory nerve development
relationship: RO:0002298 UBERON:0002019 ! results in morphogenesis of accessory XI nerve

[Term]
id: GO:0021608
name: accessory nerve formation
namespace: biological_process
def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XI biosynthesis" RELATED []
synonym: "CN XI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002019 ! results in formation of accessory XI nerve
relationship: BFO:0000050 GO:0021607 ! part of accessory nerve morphogenesis
relationship: RO:0002297 UBERON:0002019 ! results in formation of accessory XI nerve

[Term]
id: GO:0021614
name: glossopharyngeal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001649 ! results in maturation of glossopharyngeal nerve
relationship: BFO:0000050 GO:0021563 ! part of glossopharyngeal nerve development
relationship: RO:0002299 UBERON:0001649 ! results in maturation of glossopharyngeal nerve

[Term]
id: GO:0021615
name: glossopharyngeal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001649 ! results in morphogenesis of glossopharyngeal nerve
relationship: BFO:0000050 GO:0021563 ! part of glossopharyngeal nerve development
relationship: RO:0002298 UBERON:0001649 ! results in morphogenesis of glossopharyngeal nerve

[Term]
id: GO:0021616
name: glossopharyngeal nerve formation
namespace: biological_process
def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN IX biosynthesis" RELATED []
synonym: "CN IX formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001649 ! results in formation of glossopharyngeal nerve
relationship: BFO:0000050 GO:0021615 ! part of glossopharyngeal nerve morphogenesis
relationship: RO:0002297 UBERON:0001649 ! results in formation of glossopharyngeal nerve

[Term]
id: GO:0021618
name: hypoglossal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001650 ! results in morphogenesis of hypoglossal nerve
relationship: BFO:0000050 GO:0021566 ! part of hypoglossal nerve development
relationship: RO:0002298 UBERON:0001650 ! results in morphogenesis of hypoglossal nerve

[Term]
id: GO:0021619
name: hypoglossal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001650 ! results in maturation of hypoglossal nerve
relationship: BFO:0000050 GO:0021566 ! part of hypoglossal nerve development
relationship: RO:0002299 UBERON:0001650 ! results in maturation of hypoglossal nerve

[Term]
id: GO:0021620
name: hypoglossal nerve formation
namespace: biological_process
def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN XII biosynthesis" RELATED []
synonym: "CN XII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001650 ! results in formation of hypoglossal nerve
relationship: BFO:0000050 GO:0021618 ! part of hypoglossal nerve morphogenesis
relationship: RO:0002297 UBERON:0001650 ! results in formation of hypoglossal nerve

[Term]
id: GO:0021626
name: central nervous system maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system

[Term]
id: GO:0021635
name: trigeminal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve
relationship: BFO:0000050 GO:0021559 ! part of trigeminal nerve development
relationship: RO:0002299 UBERON:0001645 ! results in maturation of trigeminal nerve

[Term]
id: GO:0021636
name: trigeminal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve
relationship: BFO:0000050 GO:0021559 ! part of trigeminal nerve development
relationship: RO:0002298 UBERON:0001645 ! results in morphogenesis of trigeminal nerve

[Term]
id: GO:0021638
name: trigeminal nerve formation
namespace: biological_process
def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V biosynthesis" RELATED []
synonym: "CN V formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001645 ! results in formation of trigeminal nerve
relationship: BFO:0000050 GO:0021636 ! part of trigeminal nerve morphogenesis
relationship: RO:0002297 UBERON:0001645 ! results in formation of trigeminal nerve

[Term]
id: GO:0021643
name: vagus nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001759 ! results in maturation of vagus nerve
relationship: BFO:0000050 GO:0021564 ! part of vagus nerve development
relationship: RO:0002299 UBERON:0001759 ! results in maturation of vagus nerve

[Term]
id: GO:0021644
name: vagus nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001759 ! results in morphogenesis of vagus nerve
relationship: BFO:0000050 GO:0021564 ! part of vagus nerve development
relationship: RO:0002298 UBERON:0001759 ! results in morphogenesis of vagus nerve

[Term]
id: GO:0021646
name: vagus nerve formation
namespace: biological_process
def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN X biosynthesis" RELATED []
synonym: "CN X formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001759 ! results in formation of vagus nerve
relationship: BFO:0000050 GO:0021644 ! part of vagus nerve morphogenesis
relationship: RO:0002297 UBERON:0001759 ! results in formation of vagus nerve

[Term]
id: GO:0021651
name: rhombomere 1 morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021593 ! rhombomere morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0005499 ! results in morphogenesis of rhombomere 1
relationship: BFO:0000050 GO:0021567 ! part of rhombomere 1 development
relationship: RO:0002298 UBERON:0005499 ! results in morphogenesis of rhombomere 1

[Term]
id: GO:0021652
name: rhombomere 1 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021594 ! rhombomere formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005499 ! results in formation of rhombomere 1
relationship: BFO:0000050 GO:0021651 ! part of rhombomere 1 morphogenesis
relationship: RO:0002297 UBERON:0005499 ! results in formation of rhombomere 1

[Term]
id: GO:0021654
name: rhombomere boundary formation
namespace: biological_process
def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0018239 ! results in formation of rhombomere boundary
relationship: BFO:0000050 GO:0021594 ! part of rhombomere formation
relationship: RO:0002297 UBERON:0018239 ! results in formation of rhombomere boundary

[Term]
id: GO:0021670
name: lateral ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002285 ! results in development of telencephalic ventricle
relationship: BFO:0000050 GO:0021537 ! part of telencephalon development
relationship: BFO:0000050 GO:0021591 ! part of ventricular system development
relationship: RO:0002296 UBERON:0002285 ! results in development of telencephalic ventricle

[Term]
id: GO:0021675
name: nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001021 ! results in development of nerve
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002296 UBERON:0001021 ! results in development of nerve

[Term]
id: GO:0021678
name: third ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002286 ! results in development of third ventricle
relationship: BFO:0000050 GO:0021591 ! part of ventricular system development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002296 UBERON:0002286 ! results in development of third ventricle

[Term]
id: GO:0021679
name: cerebellar molecular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002974 ! results in development of molecular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development
relationship: RO:0002296 UBERON:0002974 ! results in development of molecular layer of cerebellar cortex

[Term]
id: GO:0021680
name: cerebellar Purkinje cell layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002979 ! results in development of Purkinje cell layer of cerebellar cortex
relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development
relationship: RO:0002296 UBERON:0002979 ! results in development of Purkinje cell layer of cerebellar cortex

[Term]
id: GO:0021681
name: cerebellar granular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002956 ! results in development of granular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development
relationship: RO:0002296 UBERON:0002956 ! results in development of granular layer of cerebellar cortex

[Term]
id: GO:0021682
name: nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001021 ! results in maturation of nerve
relationship: BFO:0000050 GO:0021675 ! part of nerve development
relationship: RO:0002299 UBERON:0001021 ! results in maturation of nerve

[Term]
id: GO:0021683
name: cerebellar granular layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002956 ! results in morphogenesis of granular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021681 ! part of cerebellar granular layer development
relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis
relationship: RO:0002298 UBERON:0002956 ! results in morphogenesis of granular layer of cerebellar cortex

[Term]
id: GO:0021684
name: cerebellar granular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002956 ! results in formation of granular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021683 ! part of cerebellar granular layer morphogenesis
relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation
relationship: RO:0002297 UBERON:0002956 ! results in formation of granular layer of cerebellar cortex

[Term]
id: GO:0021686
name: cerebellar granular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002956 ! results in maturation of granular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021681 ! part of cerebellar granular layer development
relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation
relationship: RO:0002299 UBERON:0002956 ! results in maturation of granular layer of cerebellar cortex

[Term]
id: GO:0021687
name: cerebellar molecular layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002974 ! results in morphogenesis of molecular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021679 ! part of cerebellar molecular layer development
relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis
relationship: RO:0002298 UBERON:0002974 ! results in morphogenesis of molecular layer of cerebellar cortex

[Term]
id: GO:0021688
name: cerebellar molecular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002974 ! results in formation of molecular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021687 ! part of cerebellar molecular layer morphogenesis
relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation
relationship: RO:0002297 UBERON:0002974 ! results in formation of molecular layer of cerebellar cortex

[Term]
id: GO:0021690
name: cerebellar molecular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002974 ! results in maturation of molecular layer of cerebellar cortex
relationship: BFO:0000050 GO:0021679 ! part of cerebellar molecular layer development
relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation
relationship: RO:0002299 UBERON:0002974 ! results in maturation of molecular layer of cerebellar cortex

[Term]
id: GO:0021691
name: cerebellar Purkinje cell layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002979 ! results in maturation of Purkinje cell layer of cerebellar cortex
relationship: BFO:0000050 GO:0021680 ! part of cerebellar Purkinje cell layer development
relationship: BFO:0000050 GO:0021699 ! part of cerebellar cortex maturation
relationship: RO:0002299 UBERON:0002979 ! results in maturation of Purkinje cell layer of cerebellar cortex

[Term]
id: GO:0021692
name: cerebellar Purkinje cell layer morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002979 ! results in morphogenesis of Purkinje cell layer of cerebellar cortex
relationship: BFO:0000050 GO:0021680 ! part of cerebellar Purkinje cell layer development
relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis
relationship: RO:0002298 UBERON:0002979 ! results in morphogenesis of Purkinje cell layer of cerebellar cortex

[Term]
id: GO:0021694
name: cerebellar Purkinje cell layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002979 ! results in formation of Purkinje cell layer of cerebellar cortex
relationship: BFO:0000050 GO:0021692 ! part of cerebellar Purkinje cell layer morphogenesis
relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation
relationship: RO:0002297 UBERON:0002979 ! results in formation of Purkinje cell layer of cerebellar cortex

[Term]
id: GO:0021695
name: cerebellar cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002129 ! results in development of cerebellar cortex
relationship: BFO:0000050 GO:0021549 ! part of cerebellum development
relationship: RO:0002296 UBERON:0002129 ! results in development of cerebellar cortex

[Term]
id: GO:0021696
name: cerebellar cortex morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002129 ! results in morphogenesis of cerebellar cortex
relationship: BFO:0000050 GO:0021587 ! part of cerebellum morphogenesis
relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development
relationship: RO:0002298 UBERON:0002129 ! results in morphogenesis of cerebellar cortex

[Term]
id: GO:0021697
name: cerebellar cortex formation
namespace: biological_process
def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002129 ! results in formation of cerebellar cortex
relationship: BFO:0000050 GO:0021696 ! part of cerebellar cortex morphogenesis
relationship: RO:0002297 UBERON:0002129 ! results in formation of cerebellar cortex

[Term]
id: GO:0021699
name: cerebellar cortex maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002129 ! results in maturation of cerebellar cortex
relationship: BFO:0000050 GO:0021590 ! part of cerebellum maturation
relationship: BFO:0000050 GO:0021695 ! part of cerebellar cortex development
relationship: RO:0002299 UBERON:0002129 ! results in maturation of cerebellar cortex

[Term]
id: GO:0021700
name: developmental maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
subset: goslim_chembl
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0021701
name: cerebellar Golgi cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000119 ! results in acquisition of features of cerebellar Golgi cell
relationship: BFO:0000050 GO:0021684 ! part of cerebellar granular layer formation
relationship: RO:0002315 CL:0000119 ! results in acquisition of features of cerebellar Golgi cell

[Term]
id: GO:0021702
name: cerebellar Purkinje cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000121 ! results in acquisition of features of Purkinje cell
relationship: BFO:0000050 GO:0021694 ! part of cerebellar Purkinje cell layer formation
relationship: RO:0002315 CL:0000121 ! results in acquisition of features of Purkinje cell

[Term]
id: GO:0021703
name: locus ceruleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "locus caeruleus development" EXACT []
synonym: "locus coeruleus development" EXACT []
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus
relationship: BFO:0000050 GO:0021548 ! part of pons development
relationship: RO:0002296 UBERON:0002148 ! results in development of locus ceruleus

[Term]
id: GO:0021704
name: locus ceruleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus
relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis
relationship: BFO:0000050 GO:0021703 ! part of locus ceruleus development
relationship: RO:0002298 UBERON:0002148 ! results in morphogenesis of locus ceruleus

[Term]
id: GO:0021705
name: locus ceruleus formation
namespace: biological_process
def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002148 ! results in formation of locus ceruleus
relationship: BFO:0000050 GO:0021584 ! part of pons formation
relationship: BFO:0000050 GO:0021704 ! part of locus ceruleus morphogenesis
relationship: RO:0002297 UBERON:0002148 ! results in formation of locus ceruleus

[Term]
id: GO:0021706
name: locus ceruleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus
relationship: BFO:0000050 GO:0021586 ! part of pons maturation
relationship: BFO:0000050 GO:0021703 ! part of locus ceruleus development
relationship: RO:0002299 UBERON:0002148 ! results in maturation of locus ceruleus

[Term]
id: GO:0021707
name: cerebellar granule cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:1905962 ! glutamatergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0001031 ! results in acquisition of features of cerebellar granule cell
relationship: BFO:0000050 GO:0021684 ! part of cerebellar granular layer formation
relationship: RO:0002315 CL:0001031 ! results in acquisition of features of cerebellar granule cell

[Term]
id: GO:0021708
name: Lugaro cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0011006 ! results in acquisition of features of Lugaro cell
relationship: BFO:0000050 GO:0021697 ! part of cerebellar cortex formation
relationship: RO:0002315 CL:0011006 ! results in acquisition of features of Lugaro cell

[Term]
id: GO:0021710
name: cerebellar stellate cell differentiation
namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010010 ! results in acquisition of features of cerebellar stellate cell
relationship: BFO:0000050 GO:0021688 ! part of cerebellar molecular layer formation
relationship: RO:0002315 CL:0010010 ! results in acquisition of features of cerebellar stellate cell

[Term]
id: GO:0021718
name: superior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex
relationship: BFO:0000050 GO:0021548 ! part of pons development
relationship: RO:0002296 UBERON:0007247 ! results in development of nucleus of superior olivary complex

[Term]
id: GO:0021719
name: superior olivary nucleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex
relationship: BFO:0000050 GO:0021583 ! part of pons morphogenesis
relationship: BFO:0000050 GO:0021718 ! part of superior olivary nucleus development
relationship: RO:0002298 UBERON:0007247 ! results in morphogenesis of nucleus of superior olivary complex

[Term]
id: GO:0021720
name: superior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0007247 ! results in formation of nucleus of superior olivary complex
relationship: BFO:0000050 GO:0021584 ! part of pons formation
relationship: BFO:0000050 GO:0021719 ! part of superior olivary nucleus morphogenesis
relationship: RO:0002297 UBERON:0007247 ! results in formation of nucleus of superior olivary complex

[Term]
id: GO:0021722
name: superior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex
relationship: BFO:0000050 GO:0021586 ! part of pons maturation
relationship: BFO:0000050 GO:0021718 ! part of superior olivary nucleus development
relationship: RO:0002299 UBERON:0007247 ! results in maturation of nucleus of superior olivary complex

[Term]
id: GO:0021732
name: midbrain-hindbrain boundary maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus maturation" RELATED []
synonym: "MHB maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary
relationship: BFO:0000050 GO:0030917 ! part of midbrain-hindbrain boundary development
relationship: RO:0002299 UBERON:0003052 ! results in maturation of midbrain-hindbrain boundary

[Term]
id: GO:0021743
name: hypoglossal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002871 ! results in development of hypoglossal nucleus
relationship: BFO:0000050 GO:0021550 ! part of medulla oblongata development
relationship: RO:0002296 UBERON:0002871 ! results in development of hypoglossal nucleus

[Term]
id: GO:0021751
name: salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus
relationship: BFO:0000050 GO:0021548 ! part of pons development
relationship: RO:0002296 UBERON:0004133 ! results in development of salivatory nucleus

[Term]
id: GO:0021753
name: superior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021751 ! salivary nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus
relationship: RO:0002296 UBERON:0002149 ! results in development of superior salivatory nucleus

[Term]
id: GO:0021756
name: striatum development
namespace: biological_process
def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "neostriatum development" EXACT []
synonym: "striate nucleus development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002435 ! results in development of striatum
relationship: BFO:0000050 GO:0021544 ! part of subpallium development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002296 UBERON:0002435 ! results in development of striatum

[Term]
id: GO:0021757
name: caudate nucleus development
namespace: biological_process
def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001873 ! results in development of caudate nucleus
relationship: BFO:0000050 GO:0021756 ! part of striatum development
relationship: RO:0002296 UBERON:0001873 ! results in development of caudate nucleus

[Term]
id: GO:0021758
name: putamen development
namespace: biological_process
def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001874 ! results in development of putamen
relationship: BFO:0000050 GO:0021756 ! part of striatum development
relationship: RO:0002296 UBERON:0001874 ! results in development of putamen

[Term]
id: GO:0021759
name: globus pallidus development
namespace: biological_process
def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "pallidum development" EXACT [PMID:16271465]
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001875 ! results in development of globus pallidus
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: RO:0002296 UBERON:0001875 ! results in development of globus pallidus

[Term]
id: GO:0021761
name: limbic system development
namespace: biological_process
def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000349 ! results in development of limbic system
relationship: BFO:0000050 GO:0030900 ! part of forebrain development
relationship: RO:0002296 UBERON:0000349 ! results in development of limbic system

[Term]
id: GO:0021768
name: nucleus accumbens development
namespace: biological_process
def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "accumbens nucleus development" EXACT [GOC:dgh]
synonym: "ventral striatum development" BROAD []
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001882 ! results in development of nucleus accumbens
relationship: BFO:0000050 GO:0021756 ! part of striatum development
relationship: BFO:0000050 GO:0021761 ! part of limbic system development
relationship: RO:0002296 UBERON:0001882 ! results in development of nucleus accumbens

[Term]
id: GO:0021773
name: striatal medium spiny neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420]
synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741]
synonym: "striatal MSN differentiation" EXACT [PMID:25804741]
is_a: GO:0021879 ! forebrain neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1001474 ! results in acquisition of features of medium spiny neuron
relationship: BFO:0000050 GO:0021756 ! part of striatum development
relationship: RO:0002315 CL:1001474 ! results in acquisition of features of medium spiny neuron

[Term]
id: GO:0021782
name: glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000125 ! results in development of glial cell
relationship: BFO:0000050 GO:0010001 ! part of glial cell differentiation
relationship: RO:0002296 CL:0000125 ! results in development of glial cell

[Term]
id: GO:0021783
name: preganglionic parasympathetic fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0011930 ! results in development of preganglionic parasympathetic fiber
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: BFO:0000050 GO:0048486 ! part of parasympathetic nervous system development
relationship: RO:0002296 UBERON:0011930 ! results in development of preganglionic parasympathetic fiber

[Term]
id: GO:0021794
name: thalamus development
namespace: biological_process
def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001897 ! results in development of dorsal plus ventral thalamus
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: RO:0002296 UBERON:0001897 ! results in development of dorsal plus ventral thalamus

[Term]
id: GO:0021795
name: cerebral cortex cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022029 ! telencephalon cell migration
relationship: BFO:0000050 GO:0021987 ! part of cerebral cortex development

[Term]
id: GO:0021799
name: cerebral cortex radially oriented cell migration
namespace: biological_process
def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021801
name: cerebral cortex radial glia-guided migration
namespace: biological_process
def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cerebral cortex radial glia guided migration" EXACT []
synonym: "cerebral cortex radial glia-dependent cell migration" EXACT []
synonym: "glial-guided locomotion" RELATED [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0021814
name: cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration
relationship: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration

[Term]
id: GO:0021815
name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration
relationship: BFO:0000050 GO:0021814 ! part of cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021819
name: layer formation in cerebral cortex
namespace: biological_process
def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "cerebral cortex lamination" RELATED [PMID:12626695]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: BFO:0000050 GO:0021801 ! part of cerebral cortex radial glia-guided migration

[Term]
id: GO:0021822
name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695]
synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW []
synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:1903976 ! negative regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0021814 ! negatively regulates cell motility involved in cerebral cortex radial glia guided migration
relationship: BFO:0000050 GO:0021819 ! part of layer formation in cerebral cortex
relationship: RO:0002212 GO:0021814 ! negatively regulates cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021826
name: substrate-independent telencephalic tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0021830
name: interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021843
name: substrate-independent telencephalic tangential interneuron migration
namespace: biological_process
def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration

[Term]
id: GO:0021846
name: cell proliferation in forebrain
namespace: biological_process
def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000066 UBERON:0001890 ! occurs in forebrain
relationship: BFO:0000050 GO:0030900 ! part of forebrain development
relationship: BFO:0000066 UBERON:0001890 ! occurs in forebrain

[Term]
id: GO:0021848
name: neuroblast division in subpallium
namespace: biological_process
def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0055057 ! neuroblast division
intersection_of: GO:0055057 ! neuroblast division
intersection_of: BFO:0000066 UBERON:0000204 ! occurs in ventral part of telencephalon
relationship: BFO:0000050 GO:0022012 ! part of subpallium cell proliferation in forebrain
relationship: BFO:0000066 UBERON:0000204 ! occurs in ventral part of telencephalon

[Term]
id: GO:0021852
name: pyramidal neuron migration to cerebral cortex
namespace: biological_process
def: "The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695, PMID:22192824]
synonym: "projection neuron migration" RELATED [PMID:12626695]
synonym: "pyramidal neuron migration" BROAD []
is_a: GO:0021801 ! cerebral cortex radial glia-guided migration
is_a: GO:0140650 ! radial glia-guided pyramidal neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002339 UBERON:0000956 ! has target end location cerebral cortex
intersection_of: RO:0002565 CL:0000598 ! results in movement of pyramidal neuron
relationship: BFO:0000050 GO:0021860 ! part of pyramidal neuron development
relationship: RO:0002339 UBERON:0000956 ! has target end location cerebral cortex

[Term]
id: GO:0021853
name: cerebral cortex GABAergic interneuron migration
namespace: biological_process
def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex
is_a: GO:1904936 ! interneuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0010011 ! results in movement of cerebral cortex GABAergic interneuron
relationship: BFO:0000050 GO:0021894 ! part of cerebral cortex GABAergic interneuron development
relationship: RO:0002565 CL:0010011 ! results in movement of cerebral cortex GABAergic interneuron

[Term]
id: GO:0021854
name: hypothalamus development
namespace: biological_process
def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001898 ! results in development of hypothalamus
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: BFO:0000050 GO:0021761 ! part of limbic system development
relationship: RO:0002296 UBERON:0001898 ! results in development of hypothalamus

[Term]
id: GO:0021859
name: pyramidal neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "projection neuron differentiation" BROAD [PMID:16226447]
is_a: GO:0021953 ! central nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000598 ! results in acquisition of features of pyramidal neuron
relationship: RO:0002315 CL:0000598 ! results in acquisition of features of pyramidal neuron

[Term]
id: GO:0021860
name: pyramidal neuron development
namespace: biological_process
def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "projection neuron development" BROAD [PMID:16226447]
is_a: GO:0021884 ! forebrain neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000598 ! results in development of pyramidal neuron
relationship: BFO:0000050 GO:0021859 ! part of pyramidal neuron differentiation
relationship: RO:0002296 CL:0000598 ! results in development of pyramidal neuron

[Term]
id: GO:0021861
name: forebrain radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "radial glial cell differentiation in forebrain" EXACT []
is_a: GO:0060019 ! radial glial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0013000 ! results in acquisition of features of forebrain radial glial cell
relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons
relationship: RO:0002315 CL:0013000 ! results in acquisition of features of forebrain radial glial cell

[Term]
id: GO:0021863
name: forebrain neuroblast differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447]
is_a: GO:0014016 ! neuroblast differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000042 ! results in acquisition of features of forebrain neuroblast
relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons
relationship: RO:0002315 CL:1000042 ! results in acquisition of features of forebrain neuroblast

[Term]
id: GO:0021872
name: forebrain generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "generation of neurons in forebrain" EXACT []
is_a: GO:0048699 ! generation of neurons
relationship: BFO:0000050 GO:0030900 ! part of forebrain development

[Term]
id: GO:0021879
name: forebrain neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0021953 ! central nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0012001 ! results in acquisition of features of neuron of the forebrain
relationship: BFO:0000050 GO:0021872 ! part of forebrain generation of neurons
relationship: RO:0002315 CL:0012001 ! results in acquisition of features of neuron of the forebrain

[Term]
id: GO:0021884
name: forebrain neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021954 ! central nervous system neuron development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0012001 ! results in development of neuron of the forebrain
relationship: BFO:0000050 GO:0021879 ! part of forebrain neuron differentiation
relationship: RO:0002296 CL:0012001 ! results in development of neuron of the forebrain

[Term]
id: GO:0021885
name: forebrain cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016477 ! cell migration
relationship: BFO:0000050 GO:0030900 ! part of forebrain development

[Term]
id: GO:0021892
name: cerebral cortex GABAergic interneuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021895 ! cerebral cortex neuron differentiation
is_a: GO:0097154 ! GABAergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010011 ! results in acquisition of features of cerebral cortex GABAergic interneuron
relationship: RO:0002315 CL:0010011 ! results in acquisition of features of cerebral cortex GABAergic interneuron

[Term]
id: GO:0021894
name: cerebral cortex GABAergic interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
is_a: GO:0021884 ! forebrain neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0010011 ! results in development of cerebral cortex GABAergic interneuron
relationship: BFO:0000050 GO:0021892 ! part of cerebral cortex GABAergic interneuron differentiation
relationship: RO:0002296 CL:0010011 ! results in development of cerebral cortex GABAergic interneuron

[Term]
id: GO:0021895
name: cerebral cortex neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021879 ! forebrain neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010012 ! results in acquisition of features of cerebral cortex neuron
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002315 CL:0010012 ! results in acquisition of features of cerebral cortex neuron

[Term]
id: GO:0021896
name: forebrain astrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
is_a: GO:0048708 ! astrocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0012000 ! results in acquisition of features of astrocyte of the forebrain
relationship: BFO:0000050 GO:0030900 ! part of forebrain development
relationship: RO:0002315 CL:0012000 ! results in acquisition of features of astrocyte of the forebrain

[Term]
id: GO:0021897
name: forebrain astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0014002 ! astrocyte development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0012000 ! results in development of astrocyte of the forebrain
relationship: BFO:0000050 GO:0021896 ! part of forebrain astrocyte differentiation
relationship: RO:0002296 CL:0012000 ! results in development of astrocyte of the forebrain

[Term]
id: GO:0021903
name: rostrocaudal neural tube patterning
namespace: biological_process
def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: BFO:0000050 GO:0021532 ! part of neural tube patterning

[Term]
id: GO:0021905
name: forebrain-midbrain boundary formation
namespace: biological_process
def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005075 ! results in formation of forebrain-midbrain boundary
relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning
relationship: RO:0002297 UBERON:0005075 ! results in formation of forebrain-midbrain boundary

[Term]
id: GO:0021906
name: hindbrain-spinal cord boundary formation
namespace: biological_process
def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005076 ! results in formation of hindbrain-spinal cord boundary
relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning
relationship: RO:0002297 UBERON:0005076 ! results in formation of hindbrain-spinal cord boundary

[Term]
id: GO:0021915
name: neural tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001049 ! results in development of neural tube
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development
relationship: RO:0002296 UBERON:0001049 ! results in development of neural tube

[Term]
id: GO:0021953
name: central nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002315 CL:2000029 ! results in acquisition of features of central nervous system neuron

[Term]
id: GO:0021954
name: central nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:2000029 ! results in development of central nervous system neuron
relationship: BFO:0000050 GO:0021953 ! part of central nervous system neuron differentiation
relationship: RO:0002296 CL:2000029 ! results in development of central nervous system neuron

[Term]
id: GO:0021982
name: pineal gland development
namespace: biological_process
def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "epiphysis development" EXACT [GOC:dph]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001905 ! results in development of pineal body
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: BFO:0000050 GO:0035270 ! part of endocrine system development
relationship: RO:0002296 UBERON:0001905 ! results in development of pineal body

[Term]
id: GO:0021983
name: pituitary gland development
namespace: biological_process
def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "hypophysis development" RELATED [GOC:dph]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000007 ! results in development of pituitary gland
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: BFO:0000050 GO:0035270 ! part of endocrine system development
relationship: RO:0002296 UBERON:0000007 ! results in development of pituitary gland

[Term]
id: GO:0021984
name: adenohypophysis development
namespace: biological_process
def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis development" EXACT []
synonym: "anterior pituitary development" EXACT []
synonym: "anterior pituitary gland development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002196 ! results in development of adenohypophysis
relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development
relationship: RO:0002296 UBERON:0002196 ! results in development of adenohypophysis

[Term]
id: GO:0021985
name: neurohypophysis development
namespace: biological_process
def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis development" EXACT []
synonym: "posterior pituitary development" EXACT []
synonym: "posterior pituitary gland development" EXACT []
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002198 ! results in development of neurohypophysis
relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development
relationship: RO:0002296 UBERON:0002198 ! results in development of neurohypophysis

[Term]
id: GO:0021987
name: cerebral cortex development
namespace: biological_process
def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839]
synonym: "neocortex development" RELATED [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000956 ! results in development of cerebral cortex
relationship: BFO:0000050 GO:0021543 ! part of pallium development
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002296 UBERON:0000956 ! results in development of cerebral cortex

[Term]
id: GO:0021988
name: olfactory lobe development
namespace: biological_process
def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005366 ! results in development of olfactory lobe
relationship: BFO:0000050 GO:0021537 ! part of telencephalon development
relationship: RO:0002296 UBERON:0005366 ! results in development of olfactory lobe

[Term]
id: GO:0021989
name: olfactory cortex development
namespace: biological_process
def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002894 ! results in development of olfactory cortex
relationship: BFO:0000050 GO:0021988 ! part of olfactory lobe development
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002296 UBERON:0002894 ! results in development of olfactory cortex

[Term]
id: GO:0021990
name: neural plate formation
namespace: biological_process
def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003075 ! results in formation of neural plate
relationship: BFO:0000050 GO:0001839 ! part of neural plate morphogenesis
relationship: RO:0002297 UBERON:0003075 ! results in formation of neural plate

[Term]
id: GO:0021999
name: neural plate anterior/posterior regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0022008
name: neurogenesis
namespace: biological_process
def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph]
xref: Wikipedia:Neurogenesis
is_a: GO:0030154 ! cell differentiation
relationship: BFO:0000050 GO:0007399 ! part of nervous system development

[Term]
id: GO:0022009
name: central nervous system vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001570 ! vasculogenesis
intersection_of: GO:0001570 ! vasculogenesis
intersection_of: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system
relationship: RO:0002299 UBERON:0001017 ! results in maturation of central nervous system

[Term]
id: GO:0022010
name: central nervous system myelination
namespace: biological_process
def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "myelination in central nervous system" EXACT []
is_a: GO:0032291 ! axon ensheathment in central nervous system
is_a: GO:0042552 ! myelination
intersection_of: GO:0042552 ! myelination
intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system
relationship: BFO:0000050 GO:0014003 ! part of oligodendrocyte development

[Term]
id: GO:0022011
name: myelination in peripheral nervous system
namespace: biological_process
def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "peripheral nervous system myelination" EXACT []
is_a: GO:0032292 ! peripheral nervous system axon ensheathment
is_a: GO:0042552 ! myelination
intersection_of: GO:0042552 ! myelination
intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system
relationship: BFO:0000050 GO:0014044 ! part of Schwann cell development

[Term]
id: GO:0022012
name: subpallium cell proliferation in forebrain
namespace: biological_process
def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: BFO:0000050 GO:0021544 ! part of subpallium development

[Term]
id: GO:0022029
name: telencephalon cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021885 ! forebrain cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon
relationship: BFO:0000050 GO:0021537 ! part of telencephalon development
relationship: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon

[Term]
id: GO:0022030
name: telencephalon glial cell migration
namespace: biological_process
def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0008347 ! glial cell migration
is_a: GO:0022029 ! telencephalon cell migration
intersection_of: GO:0008347 ! glial cell migration
intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon

[Term]
id: GO:0022031
name: telencephalon astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022030 ! telencephalon glial cell migration
is_a: GO:0043615 ! astrocyte cell migration
intersection_of: GO:0043615 ! astrocyte cell migration
intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon

[Term]
id: GO:0022032
name: telencephalon oligodendrocyte cell migration
namespace: biological_process
def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022030 ! telencephalon glial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon
intersection_of: RO:0004009 CL:0000128 ! has primary input oligodendrocyte
relationship: RO:0004009 CL:0000128 ! has primary input oligodendrocyte

[Term]
id: GO:0022033
name: telencephalon microglial cell migration
namespace: biological_process
def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0022030 ! telencephalon glial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002344 UBERON:0001893 ! results in transport to from or in telencephalon
intersection_of: RO:0004009 CL:0000129 ! has primary input microglial cell
relationship: RO:0004009 CL:0000129 ! has primary input microglial cell

[Term]
id: GO:0022035
name: rhombomere cell migration
namespace: biological_process
def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700]
is_a: GO:0021535 ! cell migration in hindbrain
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere
relationship: BFO:0000050 GO:0021546 ! part of rhombomere development
relationship: RO:0002344 UBERON:0001892 ! results in transport to from or in rhombomere

[Term]
id: GO:0022037
name: metencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001895 ! results in development of metencephalon
relationship: BFO:0000050 GO:0030902 ! part of hindbrain development
relationship: RO:0002296 UBERON:0001895 ! results in development of metencephalon

[Term]
id: GO:0022402
name: cell cycle process
namespace: biological_process
def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: BFO:0000050 GO:0007049 ! part of cell cycle
relationship: BFO:0000050 GO:0007049 ! part of cell cycle

[Term]
id: GO:0022403
name: cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0044848 ! biological phase

[Term]
id: GO:0022406
name: membrane docking
namespace: biological_process
def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0022407
name: regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098609 ! regulates cell-cell adhesion
relationship: RO:0002211 GO:0098609 ! regulates cell-cell adhesion

[Term]
id: GO:0022408
name: negative regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "down regulation of cell-cell adhesion" EXACT []
synonym: "down-regulation of cell-cell adhesion" EXACT []
synonym: "downregulation of cell-cell adhesion" EXACT []
synonym: "inhibition of cell-cell adhesion" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098609 ! negatively regulates cell-cell adhesion
relationship: RO:0002212 GO:0098609 ! negatively regulates cell-cell adhesion

[Term]
id: GO:0022409
name: positive regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "activation of cell-cell adhesion" NARROW []
synonym: "stimulation of cell-cell adhesion" NARROW []
synonym: "up regulation of cell-cell adhesion" EXACT []
synonym: "up-regulation of cell-cell adhesion" EXACT []
synonym: "upregulation of cell-cell adhesion" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098609 ! positively regulates cell-cell adhesion
relationship: RO:0002213 GO:0098609 ! positively regulates cell-cell adhesion

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
alt_id: GO:0071845
def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cell structure disassembly" EXACT []
synonym: "cellular component disassembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002590 GO:0005575 ! results in disassembly of cellular_component
disjoint_from: GO:0022607 ! cellular component assembly
relationship: RO:0002590 GO:0005575 ! results in disassembly of cellular_component

[Term]
id: GO:0022412
name: cellular process involved in reproduction in multicellular organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete]
synonym: "reproductive cellular process in multicellular organism" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0048609 ! multicellular organismal reproductive process
intersection_of: GO:0009987 ! cellular process
intersection_of: GO:0048609 ! multicellular organismal reproductive process

[Term]
id: GO:0022414
name: reproductive process
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0044702
alt_id: GO:0050876
def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "single organism reproductive process" RELATED []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
created_by: jl
creation_date: 2012-09-19T15:56:06Z

[Term]
id: GO:0022600
name: digestive system process
namespace: biological_process
def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]
subset: goslim_generic
is_a: GO:0003008 ! system process
intersection_of: GO:0003008 ! system process
intersection_of: BFO:0000050 GO:0007586 ! part of digestion
relationship: BFO:0000050 GO:0007586 ! part of digestion

[Term]
id: GO:0022603
name: regulation of anatomical structure morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]
synonym: "regulation of morphogenesis" EXACT []
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis
relationship: RO:0002211 GO:0009653 ! regulates anatomical structure morphogenesis

[Term]
id: GO:0022604
name: regulation of cell morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]
synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000902 ! regulates cell morphogenesis
relationship: RO:0002211 GO:0000902 ! regulates cell morphogenesis

[Term]
id: GO:0022607
name: cellular component assembly
namespace: biological_process
alt_id: GO:0071844
def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
synonym: "cell structure assembly" EXACT []
synonym: "cellular component assembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002588 GO:0005575 ! results in assembly of cellular_component
relationship: BFO:0000050 GO:0044085 ! part of cellular component biogenesis
relationship: RO:0002588 GO:0005575 ! results in assembly of cellular_component

[Term]
id: GO:0022612
name: gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland
relationship: BFO:0000050 GO:0048732 ! part of gland development
relationship: RO:0002298 UBERON:0002530 ! results in morphogenesis of gland

[Term]
id: GO:0022613
name: ribonucleoprotein complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]
synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah]
synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022617
name: extracellular matrix disassembly
namespace: biological_process
def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid]
xref: Reactome:R-HSA-1474228 "Degradation of the extracellular matrix"
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix
relationship: RO:0002590 GO:0031012 ! results in disassembly of extracellular matrix

[Term]
id: GO:0022618
name: protein-RNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]
subset: goslim_chembl
synonym: "ribonucleoprotein complex assembly" EXACT []
synonym: "RNA-protein complex assembly" EXACT []
synonym: "RNP complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0071826 ! protein-RNA complex organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex
relationship: BFO:0000050 GO:0022613 ! part of ribonucleoprotein complex biogenesis
relationship: RO:0002588 GO:1990904 ! results in assembly of ribonucleoprotein complex

[Term]
id: GO:0022626
name: cytosolic ribosome
namespace: cellular_component
def: "A ribosome located in the cytosol." [GOC:mtg_sensu]
synonym: "70S ribosome" NARROW []
synonym: "80S ribosome" NARROW []
is_a: GO:0005840 ! ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: BFO:0000050 GO:0005829 ! part of cytosol
relationship: BFO:0000050 GO:0005829 ! part of cytosol

[Term]
id: GO:0022804
name: active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
synonym: "active carrier activity" EXACT []
synonym: "carrier activity" EXACT []
synonym: "permease activity" EXACT []
synonym: "pump activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022857
name: transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "substrate-specific transmembrane transporter activity" RELATED []
synonym: "substrate-specific transporter activity" RELATED []
synonym: "uptake permease activity" RELATED []
synonym: "uptake transmembrane transporter activity" RELATED []
xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61"
xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate"
xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics"
xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate"
xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA"
xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome"
xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol"
xref: Reactome:R-HSA-8954513 "NAASP translocates from mitochondrial matrix to cytosol"
is_a: GO:0005215 ! transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
relationship: BFO:0000050 GO:0055085 ! part of transmembrane transport
relationship: RO:0002342 GO:0016020 ! results in transport across membrane

[Term]
id: GO:0022884
name: macromolecule transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule
relationship: RO:0004009 CHEBI:33694 ! has primary input biomacromolecule

[Term]
id: GO:0022898
name: regulation of transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]
subset: gocheck_obsoletion_candidate
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity
relationship: RO:0002211 GO:0022857 ! regulates transmembrane transporter activity

[Term]
id: GO:0023019
name: signal transduction involved in regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: BFO:0000050 GO:0010468 ! part of regulation of gene expression
relationship: BFO:0000050 GO:0010468 ! part of regulation of gene expression
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023023
name: MHC protein complex binding
namespace: molecular_function
def: "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0044877 ! protein-containing complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0042611 ! has primary input MHC protein complex
relationship: RO:0004009 GO:0042611 ! has primary input MHC protein complex
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023026
name: MHC class II protein complex binding
namespace: molecular_function
def: "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]
is_a: GO:0023023 ! MHC protein complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0042613 ! has primary input MHC class II protein complex
relationship: RO:0004009 GO:0042613 ! has primary input MHC class II protein complex
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023051
name: regulation of signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "regulation of signaling process" RELATED [GOC:bf]
synonym: "regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0023052 ! regulates signaling
relationship: RO:0002211 GO:0023052 ! regulates signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023052
name: signaling
namespace: biological_process
alt_id: GO:0023046
alt_id: GO:0044700
def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
subset: goslim_agr
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "biological signaling" EXACT []
synonym: "signaling process" EXACT []
synonym: "signalling" EXACT []
synonym: "signalling process" RELATED [GOC:mah]
synonym: "single organism signaling" RELATED []
is_a: GO:0050789 ! regulation of biological process
disjoint_from: GO:0044848 ! biological phase
created_by: jl
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023056
name: positive regulation of signaling
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "positive regulation of signaling process" RELATED [GOC:bf]
synonym: "positive regulation of signalling process" EXACT [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0023052 ! positively regulates signaling
relationship: RO:0002213 GO:0023052 ! positively regulates signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023057
name: negative regulation of signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "negative regulation of signaling process" RELATED [GOC:bf]
synonym: "negative regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0023052 ! negatively regulates signaling
relationship: RO:0002212 GO:0023052 ! negatively regulates signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023061
name: signal release
namespace: biological_process
def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal]
synonym: "signal secretion" EXACT [GOC:bf]
is_a: GO:0032940 ! secretion by cell
intersection_of: GO:0032940 ! secretion by cell
intersection_of: BFO:0000050 GO:0007267 ! part of cell-cell signaling
relationship: BFO:0000050 GO:0007267 ! part of cell-cell signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0030010
name: establishment of cell polarity
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
synonym: "bud site selection/establishment of cell polarity" NARROW []
synonym: "cell polarization" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030016
name: myofibril
namespace: cellular_component
def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
xref: Wikipedia:Myofibril
is_a: GO:0043292 ! contractile muscle fiber
intersection_of: GO:0043292 ! contractile muscle fiber
intersection_of: BFO:0000050 CL:0000737 ! part of striated muscle cell
relationship: BFO:0000050 CL:0000737 ! part of striated muscle cell

[Term]
id: GO:0030017
name: sarcomere
namespace: cellular_component
def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
xref: Wikipedia:Sarcomere
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0030016 ! part of myofibril

[Term]
id: GO:0030029
name: actin filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "microfilament-based process" RELATED []
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002608 GO:0005884 ! process has causal agent actin filament
relationship: RO:0002608 GO:0005884 ! process has causal agent actin filament

[Term]
id: GO:0030030
name: cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:16318917]
subset: goslim_prokaryote
synonym: "cell projection organisation" EXACT []
synonym: "cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0042995 ! results in organization of cell projection
relationship: RO:0002592 GO:0042995 ! results in organization of cell projection

[Term]
id: GO:0030031
name: cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, PMID:18391171]
synonym: "cell projection biogenesis" RELATED [GOC:mah]
synonym: "formation of a cell surface projection" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030030 ! cell projection organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0042995 ! results in assembly of cell projection
relationship: RO:0002588 GO:0042995 ! results in assembly of cell projection

[Term]
id: GO:0030033
name: microvillus assembly
namespace: biological_process
def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194]
synonym: "microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032528 ! microvillus organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005902 ! results in assembly of microvillus
relationship: RO:0002588 GO:0005902 ! results in assembly of microvillus

[Term]
id: GO:0030036
name: actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pombe
synonym: "actin cytoskeleton organisation" EXACT []
synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "actin modulating activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0030029 ! actin filament-based process
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton
relationship: RO:0002592 GO:0015629 ! results in organization of actin cytoskeleton

[Term]
id: GO:0030048
name: actin filament-based movement
namespace: biological_process
def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0030050
name: vesicle transport along actin filament
namespace: biological_process
def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament
intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle

[Term]
id: GO:0030054
name: cell junction
namespace: cellular_component
def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:26820516, PMID:28096264]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_flybase_ribbon
xref: Wikipedia:Cell_junction
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030072
name: peptide hormone secretion
namespace: biological_process
def: "The regulated release of a peptide hormone from a cell." [GOC:mah]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0046879 ! hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:25905 ! has primary input
relationship: RO:0004009 CHEBI:25905 ! has primary input

[Term]
id: GO:0030097
name: hemopoiesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
synonym: "blood cell biosynthesis" EXACT []
synonym: "blood cell formation" EXACT []
synonym: "haemopoiesis" EXACT []
synonym: "hematopoiesis" EXACT []
xref: Wikipedia:Haematopoiesis
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000988 ! results in development of hematopoietic cell
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 CL:0000988 ! results in development of hematopoietic cell

[Term]
id: GO:0030098
name: lymphocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "lymphocyte cell differentiation" EXACT []
synonym: "lymphocyte development" RELATED [GOC:add]
synonym: "lymphocytic blood cell differentiation" EXACT []
is_a: GO:0046649 ! lymphocyte activation
is_a: GO:1903131 ! mononuclear cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000542 ! results in acquisition of features of lymphocyte
relationship: RO:0002315 CL:0000542 ! results in acquisition of features of lymphocyte

[Term]
id: GO:0030099
name: myeloid cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell
relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis
relationship: RO:0002315 CL:0000763 ! results in acquisition of features of myeloid cell

[Term]
id: GO:0030100
name: regulation of endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006897 ! regulates endocytosis
relationship: RO:0002211 GO:0006897 ! regulates endocytosis

[Term]
id: GO:0030103
name: vasopressin secretion
namespace: biological_process
def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:9937 ! has primary input
relationship: RO:0004009 CHEBI:9937 ! has primary input

[Term]
id: GO:0030133
name: transport vesicle
namespace: cellular_component
def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
synonym: "constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi to vacuole transport vesicle" NARROW []
synonym: "Golgi-vacuole transport vesicle" NARROW []
synonym: "secretory vesicle" RELATED []
xref: NIF_Subcellular:sao885490876
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: BFO:0000050 GO:0012505 ! part of endomembrane system

[Term]
id: GO:0030141
name: secretory granule
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
synonym: "secretory vesicle" BROAD []
is_a: GO:0099503 ! secretory vesicle
relationship: BFO:0000050 GO:0012505 ! part of endomembrane system

[Term]
id: GO:0030150
name: protein import into mitochondrial matrix
namespace: biological_process
def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
synonym: "mitochondrial matrix protein import" EXACT []
synonym: "mitochondrial translocation" BROAD []
synonym: "protein transport into mitochondrial matrix" EXACT []
is_a: GO:0071806 ! protein transmembrane transport
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane

[Term]
id: GO:0030154
name: cell differentiation
namespace: biological_process
def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_plant_ribbon
xref: Wikipedia:Cellular_differentiation
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0048869 ! cellular developmental process
intersection_of: RO:0002315 CL:0000000 ! results in acquisition of features of cell
relationship: RO:0002315 CL:0000000 ! results in acquisition of features of cell

[Term]
id: GO:0030155
name: regulation of cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
synonym: "cell adhesion receptor regulator activity" RELATED []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007155 ! regulates cell adhesion
relationship: RO:0002211 GO:0007155 ! regulates cell adhesion

[Term]
id: GO:0030162
name: regulation of proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
synonym: "regulation of peptidolysis" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006508 ! regulates proteolysis
relationship: RO:0002211 GO:0006508 ! regulates proteolysis

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular protein breakdown" EXACT []
synonym: "cellular protein catabolic process" EXACT []
synonym: "cellular protein catabolism" EXACT []
synonym: "cellular protein degradation" EXACT []
synonym: "multicellular organismal protein catabolic process" NARROW []
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0019538 ! protein metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0030182
name: neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000540 ! results in acquisition of features of neuron
relationship: BFO:0000050 GO:0048699 ! part of generation of neurons
relationship: RO:0002315 CL:0000540 ! results in acquisition of features of neuron

[Term]
id: GO:0030186
name: melatonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
synonym: "melatonin metabolism" EXACT []
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0043603 ! amide metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:16796 ! has primary input or output
relationship: RO:0004007 CHEBI:16796 ! has primary input or output

[Term]
id: GO:0030187
name: melatonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
synonym: "melatonin anabolism" EXACT []
synonym: "melatonin biosynthesis" EXACT []
synonym: "melatonin formation" EXACT []
synonym: "melatonin synthesis" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:16796 ! has primary output
relationship: RO:0004008 CHEBI:16796 ! has primary output

[Term]
id: GO:0030198
name: extracellular matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
synonym: "extracellular matrix organisation" EXACT []
synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah]
xref: Reactome:R-HSA-1474244 "Extracellular matrix organization"
is_a: GO:0043062 ! extracellular structure organization
is_a: GO:0045229 ! external encapsulating structure organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0031012 ! results in organization of extracellular matrix
relationship: RO:0002592 GO:0031012 ! results in organization of extracellular matrix

[Term]
id: GO:0030199
name: collagen fibril organization
namespace: biological_process
def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]
synonym: "collagen fibril organisation" EXACT []
synonym: "fibrillar collagen organization" EXACT [GOC:mah]
xref: Reactome:R-HSA-1474290 "Collagen formation"
xref: Reactome:R-HSA-2214320 "Anchoring fibril formation"
xref: Reactome:R-HSA-2243919 "Crosslinking of collagen fibrils"
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0098643 ! results in organization of fibrillar collagen
relationship: RO:0002592 GO:0098643 ! results in organization of fibrillar collagen

[Term]
id: GO:0030203
name: glycosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units." [PMID:38500384]
synonym: "glycosaminoglycan metabolism" EXACT []
xref: Reactome:R-HSA-1630316 "Glycosaminoglycan metabolism"
is_a: GO:0006022 ! aminoglycan metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:18085 ! has primary input or output
relationship: RO:0004007 CHEBI:18085 ! has primary input or output

[Term]
id: GO:0030212
name: hyaluronan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932]
synonym: "hyaluronan metabolism" EXACT []
xref: Reactome:R-HSA-2142845 "Hyaluronan metabolism"
is_a: GO:0030203 ! glycosaminoglycan metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:16336 ! has primary input or output
relationship: RO:0004007 CHEBI:16336 ! has primary input or output

[Term]
id: GO:0030213
name: hyaluronan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932]
synonym: "hyaluronan anabolism" EXACT []
synonym: "hyaluronan biosynthesis" EXACT []
synonym: "hyaluronan formation" EXACT []
synonym: "hyaluronan synthesis" EXACT []
xref: Reactome:R-HSA-2142850 "Hyaluronan biosynthesis and export"
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030212 ! hyaluronan metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:16336 ! has primary output
relationship: RO:0004008 CHEBI:16336 ! has primary output

[Term]
id: GO:0030214
name: hyaluronan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid. Hyaluronan is a type of non-sulfated glycosaminoglycan composed of the repeating disaccharide unit beta(1,4)-D-glucuronic acid-beta(1,3)-N-acetyl-D-glucosamine." [PMID:33171800, PMID:35536932]
synonym: "hyaluronan breakdown" EXACT []
synonym: "hyaluronan catabolism" EXACT []
synonym: "hyaluronan degradation" EXACT []
xref: MetaCyc:PWY-7645
xref: Reactome:R-HSA-2160916 "Hyaluronan uptake and degradation"
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030212 ! hyaluronan metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:16336 ! has primary input
relationship: RO:0004009 CHEBI:16336 ! has primary input

[Term]
id: GO:0030217
name: T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah]
comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development" RELATED [GOC:add]
synonym: "T lymphocyte differentiation" EXACT []
synonym: "T-cell differentiation" EXACT []
synonym: "T-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000084 ! results in acquisition of features of T cell
relationship: RO:0002315 CL:0000084 ! results in acquisition of features of T cell

[Term]
id: GO:0030218
name: erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah]
synonym: "erythrocyte cell differentiation" EXACT []
synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph]
synonym: "RBC differentiation" EXACT [CL:0000232]
synonym: "red blood cell differentiation" EXACT [CL:0000232]
xref: Wikipedia:Erythropoiesis
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte
relationship: BFO:0000050 GO:0034101 ! part of erythrocyte homeostasis
relationship: RO:0002315 CL:0000232 ! results in acquisition of features of erythrocyte

[Term]
id: GO:0030219
name: megakaryocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah]
synonym: "megakaryocyte cell differentiation" EXACT []
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte
relationship: RO:0002315 CL:0000556 ! results in acquisition of features of megakaryocyte

[Term]
id: GO:0030224
name: monocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah]
synonym: "monocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:1903131 ! mononuclear cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000576 ! results in acquisition of features of monocyte
relationship: RO:0002315 CL:0000576 ! results in acquisition of features of monocyte

[Term]
id: GO:0030225
name: macrophage differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149]
synonym: "macrophage cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:1903131 ! mononuclear cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000235 ! results in acquisition of features of macrophage
relationship: RO:0002315 CL:0000235 ! results in acquisition of features of macrophage

[Term]
id: GO:0030239
name: myofibril assembly
namespace: biological_process
def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0097435 ! supramolecular fiber organization
is_a: GO:0140694 ! membraneless organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0030016 ! results in assembly of myofibril
relationship: BFO:0000050 GO:0055002 ! part of striated muscle cell development
relationship: RO:0002588 GO:0030016 ! results in assembly of myofibril

[Term]
id: GO:0030246
name: carbohydrate binding
namespace: molecular_function
alt_id: GO:0005529
def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "selectin" RELATED []
synonym: "sugar binding" EXACT []
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
relationship: RO:0004009 CHEBI:16646 ! has primary input carbohydrate

[Term]
id: GO:0030247
name: polysaccharide binding
namespace: molecular_function
alt_id: GO:0002506
def: "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]
synonym: "polysaccharide assembly with MHC class II protein complex" NARROW []
is_a: GO:0030246 ! carbohydrate binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide

[Term]
id: GO:0030252
name: growth hormone secretion
namespace: biological_process
def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah]
synonym: "somatotropin secretion" EXACT [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030261
name: chromosome condensation
namespace: biological_process
def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation]
synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf]
synonym: "nuclear chromosome condensation" EXACT [GOC:bf]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0030262
name: apoptotic nuclear changes
namespace: biological_process
def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptotic nuclear change" NARROW []
is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis

[Term]
id: GO:0030263
name: apoptotic chromosome condensation
namespace: biological_process
def: "The compaction of chromatin during apoptosis." [GOC:mah]
synonym: "pyknosis" EXACT []
xref: Wikipedia:Pyknosis
is_a: GO:0030261 ! chromosome condensation
relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes

[Term]
id: GO:0030264
name: nuclear fragmentation involved in apoptotic nuclear change
namespace: biological_process
def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]
synonym: "apoptotic nuclear fragmentation" EXACT []
synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "nucleus fragmentation" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0071763 ! nuclear membrane organization
intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes
relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes

[Term]
id: GO:0030278
name: regulation of ossification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "regulation of bone biosynthesis" EXACT []
synonym: "regulation of bone formation" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001503 ! regulates ossification
relationship: RO:0002211 GO:0001503 ! regulates ossification

[Term]
id: GO:0030279
name: negative regulation of ossification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "down regulation of ossification" EXACT []
synonym: "down-regulation of ossification" EXACT []
synonym: "downregulation of ossification" EXACT []
synonym: "inhibition of ossification" NARROW []
synonym: "negative regulation of bone biosynthesis" EXACT []
synonym: "negative regulation of bone formation" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001503 ! negatively regulates ossification
relationship: RO:0002212 GO:0001503 ! negatively regulates ossification

[Term]
id: GO:0030307
name: positive regulation of cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
synonym: "activation of cell growth" NARROW []
synonym: "stimulation of cell growth" NARROW []
synonym: "up regulation of cell growth" EXACT []
synonym: "up-regulation of cell growth" EXACT []
synonym: "upregulation of cell growth" EXACT []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016049 ! positively regulates cell growth
relationship: RO:0002213 GO:0016049 ! positively regulates cell growth

[Term]
id: GO:0030308
name: negative regulation of cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
synonym: "down regulation of cell growth" EXACT []
synonym: "down-regulation of cell growth" EXACT []
synonym: "downregulation of cell growth" EXACT []
synonym: "inhibition of cell growth" NARROW []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016049 ! negatively regulates cell growth
relationship: RO:0002212 GO:0016049 ! negatively regulates cell growth

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators]
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0071944 ! part of cell periphery

[Term]
id: GO:0030316
name: osteoclast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]
synonym: "osteoclast cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000092 ! results in acquisition of features of osteoclast
relationship: RO:0002315 CL:0000092 ! results in acquisition of features of osteoclast

[Term]
id: GO:0030323
name: respiratory tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000117 ! results in development of respiratory tube
relationship: RO:0002296 UBERON:0000117 ! results in development of respiratory tube

[Term]
id: GO:0030324
name: lung development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002048 ! results in development of lung
relationship: BFO:0000050 GO:0030323 ! part of respiratory tube development
relationship: BFO:0000050 GO:0060541 ! part of respiratory system development
relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata <vertebrates>
relationship: RO:0002296 UBERON:0002048 ! results in development of lung

[Term]
id: GO:0030334
name: regulation of cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016477 ! regulates cell migration
relationship: RO:0002211 GO:0016477 ! regulates cell migration

[Term]
id: GO:0030335
name: positive regulation of cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "activation of cell migration" NARROW []
synonym: "stimulation of cell migration" NARROW []
synonym: "up regulation of cell migration" EXACT []
synonym: "up-regulation of cell migration" EXACT []
synonym: "upregulation of cell migration" EXACT []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016477 ! positively regulates cell migration
relationship: RO:0002213 GO:0016477 ! positively regulates cell migration

[Term]
id: GO:0030336
name: negative regulation of cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "down regulation of cell migration" EXACT []
synonym: "down-regulation of cell migration" EXACT []
synonym: "downregulation of cell migration" EXACT []
synonym: "inhibition of cell migration" NARROW []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016477 ! negatively regulates cell migration
relationship: RO:0002212 GO:0016477 ! negatively regulates cell migration

[Term]
id: GO:0030397
name: membrane disassembly
namespace: biological_process
def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah]
synonym: "membrane breakdown" EXACT []
synonym: "membrane catabolism" EXACT []
synonym: "membrane degradation" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0016020 ! results in disassembly of membrane
relationship: RO:0002590 GO:0016020 ! results in disassembly of membrane

[Term]
id: GO:0030424
name: axon
namespace: cellular_component
def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]
xref: NIF_Subcellular:sao1770195789
xref: Wikipedia:Axon
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030425
name: dendrite
namespace: cellular_component
def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
xref: NIF_Subcellular:sao1211023249
xref: Wikipedia:Dendrite
is_a: GO:0043005 ! neuron projection
relationship: BFO:0000050 GO:0097447 ! part of dendritic tree

[Term]
id: GO:0030428
name: cell septum
namespace: cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]
subset: goslim_pir
synonym: "cross wall" EXACT []
synonym: "septum" BROAD []
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0030435
name: sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913]
comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo.
synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
synonym: "spore biosynthesis" EXACT []
synonym: "spore differentiation" EXACT []
synonym: "spore formation" EXACT []
xref: Wikipedia:Sporogenesis
is_a: GO:0043934 ! sporulation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0030436
name: asexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886]
synonym: "asexual reproductive sporulation" EXACT []
synonym: "asexual spore formation" EXACT []
synonym: "mitotic spore formation" EXACT []
synonym: "mitotic sporulation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0030447
name: filamentous growth
namespace: biological_process
def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]
subset: goslim_candida
is_a: GO:0040007 ! growth

[Term]
id: GO:0030448
name: hyphal growth
namespace: biological_process
alt_id: GO:0075061
def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]
subset: goslim_candida
synonym: "formation of symbiont invasive hypha in host" EXACT []
synonym: "formation of symbiont invasive hypha within host" EXACT []
synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT []
synonym: "invasive hyphal growth" EXACT []
synonym: "symbiont invasive hypha formation within host" EXACT []
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0030473
name: nuclear migration along microtubule
namespace: biological_process
def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]
synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT []
synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT []
synonym: "microtubule-dependent nuclear positioning" EXACT []
synonym: "microtubule-dependent nucleus positioning" EXACT []
synonym: "microtubule-mediated nuclear migration" EXACT []
synonym: "nuclear migration, microtubule-mediated" EXACT []
synonym: "nuclear movement, microtubule-mediated" BROAD []
synonym: "nucleus migration" BROAD []
synonym: "transport of nucleus by microtubules" EXACT []
synonym: "transport of nucleus, microtubule-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0072384 ! organelle transport along microtubule
intersection_of: GO:0007097 ! nuclear migration
intersection_of: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton
relationship: RO:0002341 GO:0015630 ! results in transport along microtubule cytoskeleton

[Term]
id: GO:0030485
name: smooth muscle contractile fiber
namespace: cellular_component
def: "The contractile fiber of smooth muscle cells." [GOC:mah]
is_a: GO:0043292 ! contractile muscle fiber
intersection_of: GO:0043292 ! contractile muscle fiber
intersection_of: BFO:0000050 CL:0000192 ! part of smooth muscle cell
relationship: BFO:0000050 CL:0000192 ! part of smooth muscle cell

[Term]
id: GO:0030574
name: collagen catabolic process
namespace: biological_process
def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]
synonym: "collagen breakdown" EXACT []
synonym: "collagen catabolism" EXACT []
synonym: "collagen degradation" EXACT []
xref: Reactome:R-HSA-1442490 "Collagen degradation"
is_a: GO:0009056 ! catabolic process
is_a: GO:0032963 ! collagen metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 GO:0005581 ! has primary input collagen trimer
relationship: RO:0004009 GO:0005581 ! has primary input collagen trimer

[Term]
id: GO:0030594
name: neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity'
is_a: GO:0038023 ! signaling receptor activity
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0030595
name: leukocyte chemotaxis
namespace: biological_process
def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl]
synonym: "immune cell chemotaxis" EXACT []
synonym: "leucocyte chemotaxis" EXACT []
is_a: GO:0050900 ! leukocyte migration
is_a: GO:0060326 ! cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte

[Term]
id: GO:0030658
name: transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah]
synonym: "constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0030133 ! bounding layer of transport vesicle
relationship: RO:0002007 GO:0030133 ! bounding layer of transport vesicle

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
is_a: GO:0012506 ! vesicle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0031410 ! part of cytoplasmic vesicle
relationship: BFO:0000050 GO:0031410 ! part of cytoplasmic vesicle

[Term]
id: GO:0030660
name: Golgi-associated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]
synonym: "Golgi vesicle membrane" RELATED []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005798 ! bounding layer of Golgi-associated vesicle
relationship: RO:0002007 GO:0005798 ! bounding layer of Golgi-associated vesicle

[Term]
id: GO:0030667
name: secretory granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a secretory granule." [GOC:mah]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0030141 ! bounding layer of secretory granule
relationship: RO:0002007 GO:0030141 ! bounding layer of secretory granule

[Term]
id: GO:0030705
name: cytoskeleton-dependent intracellular transport
namespace: biological_process
def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber
relationship: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber

[Term]
id: GO:0030720
name: oocyte localization involved in germarium-derived egg chamber formation
namespace: biological_process
def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT []
synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT []
synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah]
synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte localization during oogenesis" RELATED []
synonym: "oocyte positioning during oogenesis" NARROW []
synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT []
synonym: "oogenesis, oocyte localization" EXACT []
is_a: GO:0051674 ! localization of cell
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 CL:0000023 ! has primary input oocyte
relationship: BFO:0000050 GO:0007293 ! part of germarium-derived egg chamber formation
relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta
relationship: RO:0004009 CL:0000023 ! has primary input oocyte

[Term]
id: GO:0030849
name: autosome
namespace: cellular_component
def: "Any chromosome other than a sex chromosome." [GOC:mah]
comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
xref: Wikipedia:Autosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0030851
name: granulocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]
synonym: "granulocyte cell differentiation" EXACT []
xref: Reactome:R-HSA-9616222 "Transcriptional regulation of granulopoiesis"
is_a: GO:0002573 ! myeloid leukocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000094 ! results in acquisition of features of granulocyte
relationship: RO:0002315 CL:0000094 ! results in acquisition of features of granulocyte

[Term]
id: GO:0030852
name: regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030851 ! regulates granulocyte differentiation
relationship: RO:0002211 GO:0030851 ! regulates granulocyte differentiation

[Term]
id: GO:0030853
name: negative regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "down regulation of granulocyte differentiation" EXACT []
synonym: "down-regulation of granulocyte differentiation" EXACT []
synonym: "downregulation of granulocyte differentiation" EXACT []
synonym: "inhibition of granulocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030851 ! negatively regulates granulocyte differentiation
relationship: RO:0002212 GO:0030851 ! negatively regulates granulocyte differentiation

[Term]
id: GO:0030854
name: positive regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "activation of granulocyte differentiation" NARROW []
synonym: "stimulation of granulocyte differentiation" NARROW []
synonym: "up regulation of granulocyte differentiation" EXACT []
synonym: "up-regulation of granulocyte differentiation" EXACT []
synonym: "upregulation of granulocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030851 ! positively regulates granulocyte differentiation
relationship: RO:0002213 GO:0030851 ! positively regulates granulocyte differentiation

[Term]
id: GO:0030855
name: epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell
relationship: BFO:0000050 GO:0060429 ! part of epithelium development
relationship: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell

[Term]
id: GO:0030856
name: regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation
relationship: RO:0002211 GO:0030855 ! regulates epithelial cell differentiation

[Term]
id: GO:0030857
name: negative regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of epithelial cell differentiation" EXACT []
synonym: "down-regulation of epithelial cell differentiation" EXACT []
synonym: "downregulation of epithelial cell differentiation" EXACT []
synonym: "inhibition of epithelial cell differentiation" NARROW []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation
relationship: RO:0002212 GO:0030855 ! negatively regulates epithelial cell differentiation

[Term]
id: GO:0030858
name: positive regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "activation of epithelial cell differentiation" NARROW []
synonym: "stimulation of epithelial cell differentiation" NARROW []
synonym: "up regulation of epithelial cell differentiation" EXACT []
synonym: "up-regulation of epithelial cell differentiation" EXACT []
synonym: "upregulation of epithelial cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation
relationship: RO:0002213 GO:0030855 ! positively regulates epithelial cell differentiation

[Term]
id: GO:0030885
name: regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001773 ! regulates myeloid dendritic cell activation
relationship: RO:0002211 GO:0001773 ! regulates myeloid dendritic cell activation

[Term]
id: GO:0030886
name: negative regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah]
synonym: "down regulation of myeloid dendritic cell activation" EXACT []
synonym: "down-regulation of myeloid dendritic cell activation" EXACT []
synonym: "downregulation of myeloid dendritic cell activation" EXACT []
synonym: "inhibition of myeloid dendritic cell activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001773 ! negatively regulates myeloid dendritic cell activation
relationship: RO:0002212 GO:0001773 ! negatively regulates myeloid dendritic cell activation

[Term]
id: GO:0030887
name: positive regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah]
synonym: "activation of myeloid dendritic cell activation" NARROW []
synonym: "stimulation of myeloid dendritic cell activation" NARROW []
synonym: "up regulation of myeloid dendritic cell activation" EXACT []
synonym: "up-regulation of myeloid dendritic cell activation" EXACT []
synonym: "upregulation of myeloid dendritic cell activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001773 ! positively regulates myeloid dendritic cell activation
relationship: RO:0002213 GO:0001773 ! positively regulates myeloid dendritic cell activation

[Term]
id: GO:0030900
name: forebrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [PMID:4975589, PMID:4992177]
synonym: "prosencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001890 ! results in development of forebrain
relationship: BFO:0000050 GO:0007420 ! part of brain development
relationship: RO:0002296 UBERON:0001890 ! results in development of forebrain

[Term]
id: GO:0030901
name: midbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [PMID:4975589, PMID:4992177]
synonym: "mesencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001891 ! results in development of midbrain
relationship: BFO:0000050 GO:0007420 ! part of brain development
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002296 UBERON:0001891 ! results in development of midbrain

[Term]
id: GO:0030902
name: hindbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [PMID:4975589, PMID:4992177]
synonym: "rhombencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002028 ! results in development of hindbrain
relationship: BFO:0000050 GO:0007420 ! part of brain development
relationship: RO:0002296 UBERON:0002028 ! results in development of hindbrain

[Term]
id: GO:0030903
name: notochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh]
is_a: GO:0048568 ! embryonic organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002328 ! results in development of notochord
relationship: RO:0002296 UBERON:0002328 ! results in development of notochord

[Term]
id: GO:0030917
name: midbrain-hindbrain boundary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh]
synonym: "isthmic organizer development" EXACT []
synonym: "isthmomesencephalic boundary development" EXACT []
synonym: "isthmus development" EXACT []
synonym: "MHB development" EXACT []
synonym: "midbrain-hindbrain orgainizer development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary
relationship: BFO:0000050 GO:0007420 ! part of brain development
relationship: BFO:0000050 GO:0021903 ! part of rostrocaudal neural tube patterning
relationship: RO:0002296 UBERON:0003052 ! results in development of midbrain-hindbrain boundary

[Term]
id: GO:0030936
name: transmembrane collagen trimer
namespace: cellular_component
def: "Any collagen trimer that passes through a lipid bilayer membrane." [PMID:21421911]
synonym: "MACIT" EXACT [ISBN:0198599587]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0005581 ! collagen trimer
intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane

[Term]
id: GO:0030951
name: establishment or maintenance of microtubule cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030952
name: establishment or maintenance of cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah]
synonym: "cytoskeleton polarization" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030990
name: intraciliary transport particle
namespace: cellular_component
def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
subset: goslim_pir
synonym: "IFT complex" RELATED []
synonym: "intraflagellar transport complex" EXACT []
synonym: "intraflagellar transport particle" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: RO:0002216 GO:0035735 ! capable of part of intraciliary transport involved in cilium assembly

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, PMID:21123617, PMID:28089324, PMID:33605520]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
synonym: "matrisome" NARROW []
synonym: "proteinaceous extracellular matrix" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090513
xref: Wikipedia:Extracellular_matrix
is_a: GO:0030312 ! external encapsulating structure
disjoint_from: GO:0032991 ! protein-containing complex
disjoint_from: GO:0043226 ! organelle
disjoint_from: GO:0044423 ! virion component

[Term]
id: GO:0031022
name: nuclear migration along microfilament
namespace: biological_process
def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah]
synonym: "nuclear migration, microfilament-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
intersection_of: GO:0007097 ! nuclear migration
intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament

[Term]
id: GO:0031032
name: actomyosin structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.
synonym: "actomyosin organization" EXACT []
synonym: "actomyosin structure organisation" EXACT []
synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0042641 ! results in organization of actomyosin
relationship: RO:0002592 GO:0042641 ! results in organization of actomyosin

[Term]
id: GO:0031045
name: dense core granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495]
xref: NIF_Subcellular:sao772007592
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031076
name: embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "embryonic eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0031090
name: organelle membrane
namespace: cellular_component
def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]
synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606]
xref: NIF_Subcellular:sao830981606
is_a: GO:0016020 ! membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle
relationship: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle

[Term]
id: GO:0031109
name: microtubule polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
synonym: "microtubule dynamics" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031110
name: regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization
relationship: RO:0002211 GO:0031109 ! regulates microtubule polymerization or depolymerization

[Term]
id: GO:0031111
name: negative regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "downregulation of microtubule polymerization or depolymerization" EXACT []
synonym: "inhibition of microtubule polymerization or depolymerization" NARROW []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization
relationship: RO:0002212 GO:0031109 ! negatively regulates microtubule polymerization or depolymerization

[Term]
id: GO:0031112
name: positive regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "activation of microtubule polymerization or depolymerization" NARROW []
synonym: "stimulation of microtubule polymerization or depolymerization" NARROW []
synonym: "up regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "upregulation of microtubule polymerization or depolymerization" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization
relationship: RO:0002213 GO:0031109 ! positively regulates microtubule polymerization or depolymerization

[Term]
id: GO:0031113
name: regulation of microtubule polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah]
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046785 ! regulates microtubule polymerization
relationship: RO:0002211 GO:0046785 ! regulates microtubule polymerization

[Term]
id: GO:0031114
name: regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "regulation of microtubule disassembly" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007019 ! regulates microtubule depolymerization
relationship: RO:0002211 GO:0007019 ! regulates microtubule depolymerization

[Term]
id: GO:0031115
name: negative regulation of microtubule polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization" EXACT []
synonym: "down-regulation of microtubule polymerization" EXACT []
synonym: "downregulation of microtubule polymerization" EXACT []
synonym: "inhibition of microtubule polymerization" NARROW []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization
relationship: RO:0002212 GO:0046785 ! negatively regulates microtubule polymerization

[Term]
id: GO:0031116
name: positive regulation of microtubule polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "activation of microtubule polymerization" NARROW []
synonym: "stimulation of microtubule polymerization" NARROW []
synonym: "up regulation of microtubule polymerization" EXACT []
synonym: "up-regulation of microtubule polymerization" EXACT []
synonym: "upregulation of microtubule polymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization
relationship: RO:0002213 GO:0046785 ! positively regulates microtubule polymerization

[Term]
id: GO:0031117
name: positive regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "activation of microtubule depolymerization" NARROW []
synonym: "microtubule destabilization" EXACT []
synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of microtubule disassembly" EXACT []
synonym: "stimulation of microtubule depolymerization" NARROW []
synonym: "up regulation of microtubule depolymerization" EXACT []
synonym: "up-regulation of microtubule depolymerization" EXACT []
synonym: "upregulation of microtubule depolymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901881 ! positive regulation of protein depolymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization
relationship: RO:0002213 GO:0007019 ! positively regulates microtubule depolymerization

[Term]
id: GO:0031122
name: cytoplasmic microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
synonym: "cytoplasmic microtubule organisation" EXACT []
synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule
relationship: RO:0002592 GO:0005881 ! results in organization of cytoplasmic microtubule

[Term]
id: GO:0031128
name: developmental induction
namespace: biological_process
def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535]
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: BFO:0000051 GO:0045168 ! has part cell-cell signaling involved in cell fate commitment
relationship: BFO:0000051 GO:0045168 ! has part cell-cell signaling involved in cell fate commitment

[Term]
id: GO:0031143
name: pseudopodium
namespace: cellular_component
def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732]
subset: goslim_pir
synonym: "axopodium" NARROW []
synonym: "lobopodium" NARROW []
synonym: "pseudopod" EXACT []
synonym: "pseudopodial protrusion" EXACT []
synonym: "reticulopodium" NARROW []
xref: Wikipedia:Pseudopod
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0031175
name: neuron projection development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite development" NARROW [GOC:dph]
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite outgrowth" NARROW []
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: BFO:0000050 GO:0048666 ! part of neuron development
relationship: BFO:0000050 GO:0048666 ! part of neuron development

[Term]
id: GO:0031252
name: cell leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "front of cell" EXACT []
synonym: "leading edge of cell" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell

[Term]
id: GO:0031253
name: cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]
synonym: "membrane extension" RELATED []
synonym: "membrane projection" RELATED []
is_a: GO:0098590 ! plasma membrane region
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0120025 ! bounding layer of plasma membrane bounded cell projection
relationship: RO:0002007 GO:0120025 ! bounding layer of plasma membrane bounded cell projection

[Term]
id: GO:0031256
name: leading edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005886 ! part of plasma membrane
relationship: BFO:0000050 GO:0031252 ! part of cell leading edge

[Term]
id: GO:0031268
name: pseudopodium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg]
synonym: "pseudopodium organisation" EXACT []
synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0031143 ! results in organization of pseudopodium
relationship: RO:0002592 GO:0031143 ! results in organization of pseudopodium

[Term]
id: GO:0031269
name: pseudopodium assembly
namespace: biological_process
def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "pseudopodium extension" EXACT []
synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031268 ! pseudopodium organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0031143 ! results in assembly of pseudopodium
relationship: RO:0002588 GO:0031143 ! results in assembly of pseudopodium

[Term]
id: GO:0031270
name: pseudopodium retraction
namespace: biological_process
def: "The myosin-based contraction and retraction of a pseudopodium." [GOC:pg]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0031268 ! pseudopodium organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0031143 ! results in disassembly of pseudopodium
relationship: RO:0002590 GO:0031143 ! results in disassembly of pseudopodium

[Term]
id: GO:0031272
name: regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "regulation of pseudopodium formation" RELATED []
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0031269 ! regulates pseudopodium assembly
relationship: RO:0002211 GO:0031269 ! regulates pseudopodium assembly

[Term]
id: GO:0031273
name: negative regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "down regulation of pseudopodium formation" RELATED []
synonym: "down-regulation of pseudopodium formation" RELATED []
synonym: "downregulation of pseudopodium formation" RELATED []
synonym: "inhibition of pseudopodium formation" NARROW []
synonym: "negative regulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0031269 ! negatively regulates pseudopodium assembly
relationship: RO:0002212 GO:0031269 ! negatively regulates pseudopodium assembly

[Term]
id: GO:0031274
name: positive regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "activation of pseudopodium formation" NARROW []
synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph]
synonym: "stimulation of pseudopodium formation" NARROW []
synonym: "up regulation of pseudopodium formation" RELATED []
synonym: "up-regulation of pseudopodium formation" RELATED []
synonym: "upregulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0031269 ! positively regulates pseudopodium assembly
relationship: RO:0002213 GO:0031269 ! positively regulates pseudopodium assembly

[Term]
id: GO:0031333
name: negative regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]
synonym: "down regulation of protein complex assembly" EXACT []
synonym: "down-regulation of protein complex assembly" EXACT []
synonym: "downregulation of protein complex assembly" EXACT []
synonym: "inhibition of protein complex assembly" NARROW []
synonym: "negative regulation of protein complex assembly" RELATED []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly
relationship: RO:0002212 GO:0065003 ! negatively regulates protein-containing complex assembly

[Term]
id: GO:0031334
name: positive regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]
synonym: "activation of protein complex assembly" NARROW []
synonym: "positive regulation of protein complex assembly" RELATED []
synonym: "stimulation of protein complex assembly" NARROW []
synonym: "up regulation of protein complex assembly" EXACT []
synonym: "up-regulation of protein complex assembly" EXACT []
synonym: "upregulation of protein complex assembly" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly
relationship: RO:0002213 GO:0065003 ! positively regulates protein-containing complex assembly

[Term]
id: GO:0031338
name: regulation of vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006906 ! regulates vesicle fusion
relationship: RO:0002211 GO:0006906 ! regulates vesicle fusion

[Term]
id: GO:0031339
name: negative regulation of vesicle fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "down regulation of vesicle fusion" EXACT []
synonym: "down-regulation of vesicle fusion" EXACT []
synonym: "downregulation of vesicle fusion" EXACT []
synonym: "inhibition of vesicle fusion" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion
relationship: RO:0002212 GO:0006906 ! negatively regulates vesicle fusion

[Term]
id: GO:0031340
name: positive regulation of vesicle fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "activation of vesicle fusion" NARROW []
synonym: "stimulation of vesicle fusion" NARROW []
synonym: "up regulation of vesicle fusion" EXACT []
synonym: "up-regulation of vesicle fusion" EXACT []
synonym: "upregulation of vesicle fusion" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006906 ! positively regulates vesicle fusion
relationship: RO:0002213 GO:0006906 ! positively regulates vesicle fusion

[Term]
id: GO:0031344
name: regulation of cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "regulation of cell projection organisation" EXACT []
synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030030 ! regulates cell projection organization
relationship: RO:0002211 GO:0030030 ! regulates cell projection organization

[Term]
id: GO:0031345
name: negative regulation of cell projection organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "down regulation of cell projection organization" EXACT [GOC:mah]
synonym: "down-regulation of cell projection organization" EXACT []
synonym: "downregulation of cell projection organization" EXACT []
synonym: "inhibition of cell projection organization" NARROW []
synonym: "negative regulation of cell projection organisation" EXACT []
synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030030 ! negatively regulates cell projection organization
relationship: RO:0002212 GO:0030030 ! negatively regulates cell projection organization

[Term]
id: GO:0031346
name: positive regulation of cell projection organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "activation of cell projection organization" NARROW []
synonym: "positive regulation of cell projection organisation" EXACT []
synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell projection organization" NARROW []
synonym: "up regulation of cell projection organization" EXACT []
synonym: "up-regulation of cell projection organization" EXACT []
synonym: "upregulation of cell projection organization" EXACT []
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030030 ! positively regulates cell projection organization
relationship: RO:0002213 GO:0030030 ! positively regulates cell projection organization

[Term]
id: GO:0031347
name: regulation of defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006952 ! regulates defense response
relationship: RO:0002211 GO:0006952 ! regulates defense response

[Term]
id: GO:0031348
name: negative regulation of defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "down regulation of defense response" EXACT []
synonym: "down-regulation of defense response" EXACT []
synonym: "downregulation of defense response" EXACT []
synonym: "inhibition of defense response" NARROW []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006952 ! negatively regulates defense response
relationship: RO:0002212 GO:0006952 ! negatively regulates defense response

[Term]
id: GO:0031349
name: positive regulation of defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "activation of defense response" NARROW []
synonym: "stimulation of defense response" NARROW []
synonym: "up regulation of defense response" EXACT []
synonym: "up-regulation of defense response" EXACT []
synonym: "upregulation of defense response" EXACT []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006952 ! positively regulates defense response
relationship: RO:0002213 GO:0006952 ! positively regulates defense response

[Term]
id: GO:0031399
name: regulation of protein modification process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: goslim_yeast
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0036211 ! regulates protein modification process
relationship: RO:0002211 GO:0036211 ! regulates protein modification process

[Term]
id: GO:0031400
name: negative regulation of protein modification process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of protein modification" EXACT []
synonym: "down-regulation of protein modification" EXACT []
synonym: "downregulation of protein modification" EXACT []
synonym: "inhibition of protein modification" NARROW []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0036211 ! negatively regulates protein modification process
relationship: RO:0002212 GO:0036211 ! negatively regulates protein modification process

[Term]
id: GO:0031401
name: positive regulation of protein modification process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of protein modification" NARROW []
synonym: "stimulation of protein modification" NARROW []
synonym: "up regulation of protein modification" EXACT []
synonym: "up-regulation of protein modification" EXACT []
synonym: "upregulation of protein modification" EXACT []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0036211 ! positively regulates protein modification process
relationship: RO:0002213 GO:0036211 ! positively regulates protein modification process

[Term]
id: GO:0031406
name: carboxylic acid binding
namespace: molecular_function
def: "Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0043168 ! anion binding
is_a: GO:0043177 ! organic acid binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion
relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion

[Term]
id: GO:0031410
name: cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_mouse
subset: goslim_yeast
synonym: "cytoplasmic membrane bounded vesicle" RELATED []
synonym: "cytoplasmic membrane-enclosed vesicle" RELATED []
synonym: "cytoplasmic, membrane-bounded vesicle" RELATED []
xref: NIF_Subcellular:sao180601769
is_a: GO:0097708 ! intracellular vesicle
intersection_of: GO:0031982 ! vesicle
intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0031445
name: regulation of heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah]
synonym: "regulation of heterochromatin assembly" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0120261 ! regulation of heterochromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0031507 ! regulates heterochromatin formation
relationship: RO:0002211 GO:0031507 ! regulates heterochromatin formation

[Term]
id: GO:0031452
name: negative regulation of heterochromatin formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [PMID:16855380]
synonym: "chromatin decompaction" EXACT []
synonym: "chromatin decondensation" EXACT [PMID:16855380]
synonym: "down regulation of heterochromatin formation" EXACT []
synonym: "down-regulation of heterochromatin formation" EXACT []
synonym: "downregulation of heterochromatin formation" EXACT []
synonym: "inhibition of heterochromatin formation" NARROW []
synonym: "negative regulation of heterochromatin assembly" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:0120262 ! negative regulation of heterochromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0031507 ! negatively regulates heterochromatin formation
relationship: RO:0002212 GO:0031507 ! negatively regulates heterochromatin formation

[Term]
id: GO:0031453
name: positive regulation of heterochromatin formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah]
synonym: "activation of heterochromatin formation" NARROW []
synonym: "positive regulation of heterochromatin assembly" EXACT []
synonym: "stimulation of heterochromatin formation" NARROW []
synonym: "up regulation of heterochromatin formation" EXACT []
synonym: "up-regulation of heterochromatin formation" EXACT []
synonym: "upregulation of heterochromatin formation" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0120263 ! positive regulation of heterochromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0031507 ! positively regulates heterochromatin formation
relationship: RO:0002213 GO:0031507 ! positively regulates heterochromatin formation

[Term]
id: GO:0031503
name: protein-containing complex localization
namespace: biological_process
alt_id: GO:0034629
def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "cellular protein complex localisation" RELATED [GOC:mah]
synonym: "cellular protein complex localization" RELATED []
synonym: "cellular protein-containing complex localization" RELATED []
synonym: "establishment and maintenance of cellular protein complex localization" RELATED []
synonym: "establishment and maintenance of protein complex localization" EXACT []
synonym: "protein complex localisation" EXACT [GOC:mah]
synonym: "protein complex localization" RELATED []
is_a: GO:0033036 ! macromolecule localization
intersection_of: GO:0033036 ! macromolecule localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex
intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex
relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex

[Term]
id: GO:0031507
name: heterochromatin formation
namespace: biological_process
def: "An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924]
synonym: "chromatin silencing" EXACT []
synonym: "chromatin-mediated silencing" EXACT []
synonym: "establishment of chromatin silencing" RELATED []
synonym: "establishment of heterochromatic silencing" RELATED []
synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah]
synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie]
synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie]
synonym: "heterochromatic silencing" RELATED []
synonym: "heterochromatin assembly" EXACT []
synonym: "heterochromatin assembly involved in chromatin silencing" RELATED []
synonym: "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW []
synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie]
synonym: "heterochromatin formation involved in chromatin silencing" RELATED []
synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie]
synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie]
synonym: "heterochromatin maintenance" BROAD []
synonym: "TGS" BROAD []
synonym: "transcriptional gene silencing" RELATED []
xref: Reactome:R-HSA-5334118 "DNA methylation"
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045814 ! negative regulation of gene expression, epigenetic
is_a: GO:0070828 ! heterochromatin organization
intersection_of: GO:0006325 ! chromatin organization
intersection_of: RO:0002588 GO:0000792 ! results in assembly of heterochromatin
relationship: RO:0002230 GO:0033696 ! ends with heterochromatin boundary formation
relationship: RO:0002588 GO:0000792 ! results in assembly of heterochromatin

[Term]
id: GO:0031514
name: motile cilium
namespace: cellular_component
def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]
synonym: "microtubule-based flagellum" RELATED []
synonym: "motile cilia" EXACT []
synonym: "motile primary cilia" RELATED []
synonym: "motile primary cilium" RELATED []
synonym: "motile secondary cilium" RELATED []
synonym: "nodal cilium" RELATED []
is_a: GO:0005929 ! cilium
intersection_of: GO:0005929 ! cilium
intersection_of: RO:0002215 GO:0003341 ! capable of cilium movement
relationship: RO:0002215 GO:0003341 ! capable of cilium movement

[Term]
id: GO:0031594
name: neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512]
synonym: "NMJ" RELATED [GOC:ha]
xref: NIF_Subcellular:sao1124888485
xref: Wikipedia:Neuromuscular_junction
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron
intersection_of: RO:0002131 CL:0000187 ! overlaps muscle cell
relationship: RO:0002131 CL:0000100 ! overlaps motor neuron
relationship: RO:0002131 CL:0000187 ! overlaps muscle cell

[Term]
id: GO:0031641
name: regulation of myelination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042552 ! regulates myelination
relationship: RO:0002211 GO:0042552 ! regulates myelination

[Term]
id: GO:0031642
name: negative regulation of myelination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "down regulation of myelination" EXACT []
synonym: "down-regulation of myelination" EXACT []
synonym: "downregulation of myelination" EXACT []
synonym: "inhibition of myelination" NARROW []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042552 ! negatively regulates myelination
relationship: RO:0002212 GO:0042552 ! negatively regulates myelination

[Term]
id: GO:0031643
name: positive regulation of myelination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "activation of myelination" NARROW []
synonym: "stimulation of myelination" NARROW []
synonym: "up regulation of myelination" EXACT []
synonym: "up-regulation of myelination" EXACT []
synonym: "upregulation of myelination" EXACT []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042552 ! positively regulates myelination
relationship: RO:0002213 GO:0042552 ! positively regulates myelination

[Term]
id: GO:0031644
name: regulation of nervous system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurological system process" EXACT []
synonym: "regulation of neurophysiological process" EXACT []
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050877 ! regulates nervous system process
relationship: RO:0002211 GO:0050877 ! regulates nervous system process

[Term]
id: GO:0031645
name: negative regulation of nervous system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of neurological process" EXACT []
synonym: "down-regulation of neurological process" EXACT []
synonym: "downregulation of neurological process" EXACT []
synonym: "inhibition of neurological process" NARROW []
synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of neurological system process" EXACT []
synonym: "negative regulation of neurophysiological process" EXACT []
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050877 ! negatively regulates nervous system process
relationship: RO:0002212 GO:0050877 ! negatively regulates nervous system process

[Term]
id: GO:0031646
name: positive regulation of nervous system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of neurological process" NARROW []
synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of neurological system process" EXACT []
synonym: "positive regulation of neurophysiological process" EXACT []
synonym: "stimulation of neurological process" NARROW []
synonym: "up regulation of neurological process" EXACT []
synonym: "up-regulation of neurological process" EXACT []
synonym: "upregulation of neurological process" EXACT []
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050877 ! positively regulates nervous system process
relationship: RO:0002213 GO:0050877 ! positively regulates nervous system process

[Term]
id: GO:0031727
name: CCR2 chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR2 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR2 chemokine receptor ligand" NARROW []
synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000001199 ! has primary input C-C chemokine receptor type 2
relationship: RO:0004009 PR:000001199 ! has primary input C-C chemokine receptor type 2

[Term]
id: GO:0031965
name: nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
xref: NIF_Subcellular:sao1687101204
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0005634 ! part of nucleus
relationship: BFO:0000050 GO:0005635 ! part of nuclear envelope

[Term]
id: GO:0031966
name: mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]
xref: NIF_Subcellular:sao1045389829
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion
relationship: BFO:0000050 GO:0005740 ! part of mitochondrial envelope

[Term]
id: GO:0031967
name: organelle envelope
namespace: cellular_component
def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]
subset: goslim_mouse
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0043227 ! part of membrane-bounded organelle
relationship: BFO:0000050 GO:0043229 ! part of intracellular organelle

[Term]
id: GO:0031968
name: organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah]
is_a: GO:0019867 ! outer membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0031967 ! part of organelle envelope
intersection_of: RO:0002007 GO:0043226 ! bounding layer of organelle
relationship: BFO:0000050 GO:0031967 ! part of organelle envelope

[Term]
id: GO:0031969
name: chloroplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz]
xref: Wikipedia:Chloroplast_membrane
is_a: GO:0042170 ! plastid membrane
relationship: BFO:0000050 GO:0009941 ! part of chloroplast envelope

[Term]
id: GO:0031974
name: membrane-enclosed lumen
namespace: cellular_component
def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
disjoint_from: GO:0045202 ! synapse

[Term]
id: GO:0031981
name: nuclear lumen
namespace: cellular_component
def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: BFO:0000050 GO:0005634 ! part of nucleus

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]
subset: goslim_pir
synonym: "membrane-bounded vesicle" RELATED []
synonym: "membrane-enclosed vesicle" RELATED []
xref: NIF_Subcellular:sao221389602
xref: Wikipedia:Vesicle_(biology)
is_a: GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0032042
name: mitochondrial DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA metabolism" EXACT []
synonym: "mtDNA metabolic process" EXACT []
synonym: "mtDNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
intersection_of: GO:0006259 ! DNA metabolic process
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0032043
name: mitochondrial DNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA breakdown" EXACT []
synonym: "mitochondrial DNA catabolism" EXACT []
synonym: "mitochondrial DNA degradation" EXACT []
synonym: "mtDNA breakdown" EXACT []
synonym: "mtDNA catabolic process" EXACT []
synonym: "mtDNA catabolism" EXACT []
synonym: "mtDNA degradation" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0032042 ! mitochondrial DNA metabolic process
intersection_of: GO:0006308 ! DNA catabolic process
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion

[Term]
id: GO:0032055
name: negative regulation of translation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation in response to stress" EXACT []
synonym: "down-regulation of translation in response to stress" EXACT []
synonym: "downregulation of translation in response to stress" EXACT []
synonym: "inhibition of translation in response to stress" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043555 ! regulation of translation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation

[Term]
id: GO:0032056
name: positive regulation of translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation in response to stress" NARROW []
synonym: "stimulation of translation in response to stress" NARROW []
synonym: "up regulation of translation in response to stress" EXACT []
synonym: "up-regulation of translation in response to stress" EXACT []
synonym: "upregulation of translation in response to stress" EXACT []
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002213 GO:0006412 ! positively regulates translation

[Term]
id: GO:0032057
name: negative regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation initiation in response to stress" EXACT []
synonym: "down-regulation of translation initiation in response to stress" EXACT []
synonym: "downregulation of translation initiation in response to stress" EXACT []
synonym: "inhibition of translation initiation in response to stress" NARROW []
is_a: GO:0045947 ! negative regulation of translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0006950 ! part of response to stress
intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation
relationship: BFO:0000050 GO:0006950 ! part of response to stress

[Term]
id: GO:0032058
name: positive regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation initiation in response to stress" NARROW []
synonym: "stimulation of translation initiation in response to stress" NARROW []
synonym: "up regulation of translation initiation in response to stress" EXACT []
synonym: "up-regulation of translation initiation in response to stress" EXACT []
synonym: "upregulation of translation initiation in response to stress" EXACT []
is_a: GO:0045948 ! positive regulation of translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0006950 ! part of response to stress
intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation
relationship: BFO:0000050 GO:0006950 ! part of response to stress

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
subset: goslim_pir
synonym: "plasma membrane bleb" EXACT [GOC:pr]
xref: Wikipedia:Bleb_(cell_biology)
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0032060
name: bleb assembly
namespace: biological_process
def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
synonym: "blebbing" BROAD [GOC:pr]
synonym: "cell blebbing" EXACT []
synonym: "membrane blebbing" BROAD [GOC:pr]
synonym: "plasma membrane bleb assembly" EXACT [GOC:pr]
synonym: "plasma membrane blebbing" EXACT [GOC:pr]
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0032059 ! results in assembly of bleb
relationship: RO:0002588 GO:0032059 ! results in assembly of bleb

[Term]
id: GO:0032065
name: maintenance of protein location in cell cortex
namespace: biological_process
def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw]
synonym: "cortical protein anchoring" RELATED []
is_a: GO:0032507 ! maintenance of protein location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 GO:0005938 ! occurs in cell cortex
relationship: BFO:0000066 GO:0005938 ! occurs in cell cortex

[Term]
id: GO:0032077
name: positive regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activator" RELATED []
synonym: "DNase activator" RELATED []
synonym: "stimulation of deoxyribonuclease activity" NARROW []
synonym: "up regulation of deoxyribonuclease activity" EXACT []
synonym: "up-regulation of deoxyribonuclease activity" EXACT []
synonym: "upregulation of deoxyribonuclease activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051054 ! positive regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0004536 ! positively regulates DNA nuclease activity
relationship: RO:0002213 GO:0004536 ! positively regulates DNA nuclease activity

[Term]
id: GO:0032091
name: negative regulation of protein binding
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of protein binding" EXACT []
synonym: "down-regulation of protein binding" EXACT []
synonym: "downregulation of protein binding" EXACT []
synonym: "inhibition of protein binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051100 ! negative regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005515 ! negatively regulates protein binding
relationship: RO:0002212 GO:0005515 ! negatively regulates protein binding

[Term]
id: GO:0032092
name: positive regulation of protein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of protein binding" NARROW []
synonym: "stimulation of protein binding" NARROW []
synonym: "up regulation of protein binding" EXACT []
synonym: "up-regulation of protein binding" EXACT []
synonym: "upregulation of protein binding" EXACT []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051099 ! positive regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0005515 ! positively regulates protein binding
relationship: RO:0002213 GO:0005515 ! positively regulates protein binding

[Term]
id: GO:0032101
name: regulation of response to external stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009605 ! regulates response to external stimulus
relationship: RO:0002211 GO:0009605 ! regulates response to external stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to external stimulus" EXACT []
synonym: "down-regulation of response to external stimulus" EXACT []
synonym: "downregulation of response to external stimulus" EXACT []
synonym: "inhibition of response to external stimulus" NARROW []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus
relationship: RO:0002212 GO:0009605 ! negatively regulates response to external stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to external stimulus" NARROW []
synonym: "stimulation of response to external stimulus" NARROW []
synonym: "up regulation of response to external stimulus" EXACT []
synonym: "up-regulation of response to external stimulus" EXACT []
synonym: "upregulation of response to external stimulus" EXACT []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009605 ! positively regulates response to external stimulus
relationship: RO:0002213 GO:0009605 ! positively regulates response to external stimulus

[Term]
id: GO:0032127
name: dense core granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense core granule." [GOC:mah]
synonym: "dense core vesicle membrane" EXACT [GOC:kmv]
is_a: GO:0030667 ! secretory granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0031045 ! bounding layer of dense core granule
relationship: RO:0002007 GO:0031045 ! bounding layer of dense core granule

[Term]
id: GO:0032179
name: germ tube
namespace: cellular_component
def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148]
subset: goslim_pir
xref: Wikipedia:Germ_tube
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0032222
name: regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic
relationship: RO:0002211 GO:0007271 ! regulates synaptic transmission, cholinergic

[Term]
id: GO:0032223
name: negative regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "down regulation of synaptic transmission, cholinergic" EXACT []
synonym: "down-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "downregulation of synaptic transmission, cholinergic" EXACT []
synonym: "inhibition of synaptic transmission, cholinergic" NARROW []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic
relationship: RO:0002212 GO:0007271 ! negatively regulates synaptic transmission, cholinergic

[Term]
id: GO:0032224
name: positive regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "activation of synaptic transmission, cholinergic" NARROW []
synonym: "stimulation of synaptic transmission, cholinergic" NARROW []
synonym: "up regulation of synaptic transmission, cholinergic" EXACT []
synonym: "up-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "upregulation of synaptic transmission, cholinergic" EXACT []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic
relationship: RO:0002213 GO:0007271 ! positively regulates synaptic transmission, cholinergic

[Term]
id: GO:0032225
name: regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001963 ! regulates synaptic transmission, dopaminergic
relationship: RO:0002211 GO:0001963 ! regulates synaptic transmission, dopaminergic

[Term]
id: GO:0032226
name: positive regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "activation of synaptic transmission, dopaminergic" NARROW []
synonym: "stimulation of synaptic transmission, dopaminergic" NARROW []
synonym: "up regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "upregulation of synaptic transmission, dopaminergic" EXACT []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001963 ! positively regulates synaptic transmission, dopaminergic
relationship: RO:0002213 GO:0001963 ! positively regulates synaptic transmission, dopaminergic

[Term]
id: GO:0032227
name: negative regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "down regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "downregulation of synaptic transmission, dopaminergic" EXACT []
synonym: "inhibition of synaptic transmission, dopaminergic" NARROW []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001963 ! negatively regulates synaptic transmission, dopaminergic
relationship: RO:0002212 GO:0001963 ! negatively regulates synaptic transmission, dopaminergic

[Term]
id: GO:0032228
name: regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051932 ! regulates synaptic transmission, GABAergic
relationship: RO:0002211 GO:0051932 ! regulates synaptic transmission, GABAergic

[Term]
id: GO:0032229
name: negative regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "down regulation of synaptic transmission, GABAergic" EXACT []
synonym: "down-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "downregulation of synaptic transmission, GABAergic" EXACT []
synonym: "inhibition of synaptic transmission, GABAergic" NARROW []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051932 ! negatively regulates synaptic transmission, GABAergic
relationship: RO:0002212 GO:0051932 ! negatively regulates synaptic transmission, GABAergic

[Term]
id: GO:0032230
name: positive regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "activation of synaptic transmission, GABAergic" NARROW []
synonym: "stimulation of synaptic transmission, GABAergic" NARROW []
synonym: "up regulation of synaptic transmission, GABAergic" EXACT []
synonym: "up-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "upregulation of synaptic transmission, GABAergic" EXACT []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051932 ! positively regulates synaptic transmission, GABAergic
relationship: RO:0002213 GO:0051932 ! positively regulates synaptic transmission, GABAergic

[Term]
id: GO:0032231
name: regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0110053 ! regulation of actin filament organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly
relationship: RO:0002211 GO:0051017 ! regulates actin filament bundle assembly

[Term]
id: GO:0032232
name: negative regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "down regulation of actin filament bundle formation" EXACT []
synonym: "down-regulation of actin filament bundle formation" EXACT []
synonym: "downregulation of actin filament bundle formation" EXACT []
synonym: "inhibition of actin filament bundle formation" NARROW []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly
relationship: RO:0002212 GO:0051017 ! negatively regulates actin filament bundle assembly

[Term]
id: GO:0032233
name: positive regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "activation of actin filament bundle formation" NARROW []
synonym: "stimulation of actin filament bundle formation" NARROW []
synonym: "up regulation of actin filament bundle formation" EXACT []
synonym: "up-regulation of actin filament bundle formation" EXACT []
synonym: "upregulation of actin filament bundle formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly
relationship: RO:0002213 GO:0051017 ! positively regulates actin filament bundle assembly

[Term]
id: GO:0032239
name: regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport
relationship: RO:0002211 GO:0015931 ! regulates nucleobase-containing compound transport

[Term]
id: GO:0032240
name: negative regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport
relationship: RO:0002212 GO:0015931 ! negatively regulates nucleobase-containing compound transport

[Term]
id: GO:0032241
name: positive regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport
relationship: RO:0002213 GO:0015931 ! positively regulates nucleobase-containing compound transport

[Term]
id: GO:0032252
name: secretory granule localization
namespace: biological_process
def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "secretory granule clustering" RELATED []
synonym: "secretory granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0030141 ! has primary input secretory granule
relationship: RO:0004009 GO:0030141 ! has primary input secretory granule

[Term]
id: GO:0032253
name: dense core granule localization
namespace: biological_process
def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "dense core granule clustering" RELATED []
synonym: "dense core granule localisation" EXACT [GOC:mah]
synonym: "dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032252 ! secretory granule localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule
relationship: RO:0004009 GO:0031045 ! has primary input dense core granule

[Term]
id: GO:0032271
name: regulation of protein polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "regulation of protein polymerisation" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051258 ! regulates protein polymerization
relationship: RO:0002211 GO:0051258 ! regulates protein polymerization

[Term]
id: GO:0032272
name: negative regulation of protein polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "down regulation of protein polymerization" EXACT []
synonym: "down-regulation of protein polymerization" EXACT []
synonym: "downregulation of protein polymerization" EXACT []
synonym: "inhibition of protein polymerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051258 ! negatively regulates protein polymerization
relationship: RO:0002212 GO:0051258 ! negatively regulates protein polymerization

[Term]
id: GO:0032273
name: positive regulation of protein polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "activation of protein polymerization" NARROW []
synonym: "stimulation of protein polymerization" NARROW []
synonym: "up regulation of protein polymerization" EXACT []
synonym: "up-regulation of protein polymerization" EXACT []
synonym: "upregulation of protein polymerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051258 ! positively regulates protein polymerization
relationship: RO:0002213 GO:0051258 ! positively regulates protein polymerization

[Term]
id: GO:0032274
name: gonadotropin secretion
namespace: biological_process
def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544]
synonym: "gonadotrophin secretion" EXACT []
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032275
name: luteinizing hormone secretion
namespace: biological_process
def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732]
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032276
name: regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "regulation of gonadotrophin secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032274 ! regulates gonadotropin secretion
relationship: RO:0002211 GO:0032274 ! regulates gonadotropin secretion

[Term]
id: GO:0032277
name: negative regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "down regulation of gonadotropin secretion" EXACT []
synonym: "down-regulation of gonadotropin secretion" EXACT []
synonym: "downregulation of gonadotropin secretion" EXACT []
synonym: "inhibition of gonadotropin secretion" NARROW []
synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph]
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032274 ! negatively regulates gonadotropin secretion
relationship: RO:0002212 GO:0032274 ! negatively regulates gonadotropin secretion

[Term]
id: GO:0032278
name: positive regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "activation of gonadotropin secretion" NARROW []
synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph]
synonym: "stimulation of gonadotropin secretion" NARROW []
synonym: "up regulation of gonadotropin secretion" EXACT []
synonym: "up-regulation of gonadotropin secretion" EXACT []
synonym: "upregulation of gonadotropin secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032274 ! positively regulates gonadotropin secretion
relationship: RO:0002213 GO:0032274 ! positively regulates gonadotropin secretion

[Term]
id: GO:0032288
name: myelin assembly
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "myelin formation" RELATED [GOC:dph, GOC:tb]
synonym: "myelin sheath assembly" EXACT []
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0043209 ! results in assembly of myelin sheath
relationship: BFO:0000050 GO:0042552 ! part of myelination
relationship: RO:0002588 GO:0043209 ! results in assembly of myelin sheath

[Term]
id: GO:0032289
name: central nervous system myelin formation
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh]
synonym: "central nervous system myelin sheath formation" EXACT []
synonym: "myelin formation in central nervous system" EXACT []
is_a: GO:0032288 ! myelin assembly
intersection_of: GO:0032288 ! myelin assembly
intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system
relationship: BFO:0000050 GO:0022010 ! part of central nervous system myelination

[Term]
id: GO:0032290
name: peripheral nervous system myelin formation
namespace: biological_process
def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system." [GOC:dgh]
synonym: "myelin formation in peripheral nervous system" EXACT []
synonym: "peripheral nervous system myelin sheath formation" EXACT []
is_a: GO:0032288 ! myelin assembly
intersection_of: GO:0032288 ! myelin assembly
intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system
relationship: BFO:0000050 GO:0022011 ! part of myelination in peripheral nervous system

[Term]
id: GO:0032291
name: axon ensheathment in central nervous system
namespace: biological_process
def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
synonym: "ensheathment of axons in central nervous system" EXACT []
is_a: GO:0008366 ! axon ensheathment
intersection_of: GO:0008366 ! axon ensheathment
intersection_of: BFO:0000066 UBERON:0001017 ! occurs in central nervous system
relationship: BFO:0000066 UBERON:0001017 ! occurs in central nervous system
relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria

[Term]
id: GO:0032292
name: peripheral nervous system axon ensheathment
namespace: biological_process
def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
synonym: "ensheathment of axons in peripheral nervous system" EXACT []
is_a: GO:0008366 ! axon ensheathment
intersection_of: GO:0008366 ! axon ensheathment
intersection_of: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system
relationship: BFO:0000066 UBERON:0000010 ! occurs in peripheral nervous system

[Term]
id: GO:0032330
name: regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation
relationship: RO:0002211 GO:0002062 ! regulates chondrocyte differentiation

[Term]
id: GO:0032331
name: negative regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "down regulation of chondrocyte differentiation" EXACT []
synonym: "down-regulation of chondrocyte differentiation" EXACT []
synonym: "downregulation of chondrocyte differentiation" EXACT []
synonym: "inhibition of chondrocyte differentiation" NARROW []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0061037 ! negative regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation
relationship: RO:0002212 GO:0002062 ! negatively regulates chondrocyte differentiation

[Term]
id: GO:0032332
name: positive regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "activation of chondrocyte differentiation" NARROW []
synonym: "stimulation of chondrocyte differentiation" NARROW []
synonym: "up regulation of chondrocyte differentiation" EXACT []
synonym: "up-regulation of chondrocyte differentiation" EXACT []
synonym: "upregulation of chondrocyte differentiation" EXACT []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0061036 ! positive regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation
relationship: RO:0002213 GO:0002062 ! positively regulates chondrocyte differentiation

[Term]
id: GO:0032350
name: regulation of hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "regulation of hormone metabolism" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042445 ! regulates hormone metabolic process
relationship: RO:0002211 GO:0042445 ! regulates hormone metabolic process

[Term]
id: GO:0032351
name: negative regulation of hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "down regulation of hormone metabolic process" EXACT []
synonym: "down-regulation of hormone metabolic process" EXACT []
synonym: "downregulation of hormone metabolic process" EXACT []
synonym: "inhibition of hormone metabolic process" NARROW []
synonym: "negative regulation of hormone metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042445 ! negatively regulates hormone metabolic process
relationship: RO:0002212 GO:0042445 ! negatively regulates hormone metabolic process

[Term]
id: GO:0032352
name: positive regulation of hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "activation of hormone metabolic process" NARROW []
synonym: "positive regulation of hormone metabolism" EXACT []
synonym: "stimulation of hormone metabolic process" NARROW []
synonym: "up regulation of hormone metabolic process" EXACT []
synonym: "up-regulation of hormone metabolic process" EXACT []
synonym: "upregulation of hormone metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042445 ! positively regulates hormone metabolic process
relationship: RO:0002213 GO:0042445 ! positively regulates hormone metabolic process

[Term]
id: GO:0032353
name: negative regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "down regulation of hormone biosynthetic process" EXACT []
synonym: "down-regulation of hormone biosynthetic process" EXACT []
synonym: "downregulation of hormone biosynthetic process" EXACT []
synonym: "inhibition of hormone biosynthetic process" NARROW []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042446 ! negatively regulates hormone biosynthetic process
relationship: RO:0002212 GO:0042446 ! negatively regulates hormone biosynthetic process

[Term]
id: GO:0032365
name: intracellular lipid transport
namespace: biological_process
def: "The directed movement of lipids within cells." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0032368
name: regulation of lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:1905952 ! regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006869 ! regulates lipid transport
relationship: RO:0002211 GO:0006869 ! regulates lipid transport

[Term]
id: GO:0032369
name: negative regulation of lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of lipid transport" EXACT []
synonym: "down-regulation of lipid transport" EXACT []
synonym: "downregulation of lipid transport" EXACT []
synonym: "inhibition of lipid transport" NARROW []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1905953 ! negative regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006869 ! negatively regulates lipid transport
relationship: RO:0002212 GO:0006869 ! negatively regulates lipid transport

[Term]
id: GO:0032370
name: positive regulation of lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of lipid transport" NARROW []
synonym: "stimulation of lipid transport" NARROW []
synonym: "up regulation of lipid transport" EXACT []
synonym: "up-regulation of lipid transport" EXACT []
synonym: "upregulation of lipid transport" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1905954 ! positive regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006869 ! positively regulates lipid transport
relationship: RO:0002213 GO:0006869 ! positively regulates lipid transport

[Term]
id: GO:0032377
name: regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032365 ! regulates intracellular lipid transport
relationship: RO:0002211 GO:0032365 ! regulates intracellular lipid transport

[Term]
id: GO:0032378
name: negative regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "down regulation of intracellular lipid transport" EXACT []
synonym: "down-regulation of intracellular lipid transport" EXACT []
synonym: "downregulation of intracellular lipid transport" EXACT []
synonym: "inhibition of intracellular lipid transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032387 ! negative regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport
relationship: RO:0002212 GO:0032365 ! negatively regulates intracellular lipid transport

[Term]
id: GO:0032379
name: positive regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "activation of intracellular lipid transport" NARROW []
synonym: "stimulation of intracellular lipid transport" NARROW []
synonym: "up regulation of intracellular lipid transport" EXACT []
synonym: "up-regulation of intracellular lipid transport" EXACT []
synonym: "upregulation of intracellular lipid transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032388 ! positive regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport
relationship: RO:0002213 GO:0032365 ! positively regulates intracellular lipid transport

[Term]
id: GO:0032386
name: regulation of intracellular transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
subset: gocheck_do_not_annotate
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046907 ! regulates intracellular transport
relationship: RO:0002211 GO:0046907 ! regulates intracellular transport

[Term]
id: GO:0032387
name: negative regulation of intracellular transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "down regulation of intracellular transport" EXACT []
synonym: "down-regulation of intracellular transport" EXACT []
synonym: "downregulation of intracellular transport" EXACT []
synonym: "inhibition of intracellular transport" NARROW []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046907 ! negatively regulates intracellular transport
relationship: RO:0002212 GO:0046907 ! negatively regulates intracellular transport

[Term]
id: GO:0032388
name: positive regulation of intracellular transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "activation of intracellular transport" NARROW []
synonym: "stimulation of intracellular transport" NARROW []
synonym: "up regulation of intracellular transport" EXACT []
synonym: "up-regulation of intracellular transport" EXACT []
synonym: "upregulation of intracellular transport" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046907 ! positively regulates intracellular transport
relationship: RO:0002213 GO:0046907 ! positively regulates intracellular transport

[Term]
id: GO:0032410
name: negative regulation of transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a transporter." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of transporter activity" EXACT []
synonym: "down-regulation of transporter activity" EXACT []
synonym: "downregulation of transporter activity" EXACT []
synonym: "inhibition of transporter activity" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005215 ! negatively regulates transporter activity
relationship: RO:0002212 GO:0005215 ! negatively regulates transporter activity

[Term]
id: GO:0032411
name: positive regulation of transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a transporter." [GOC:mah]
subset: gocheck_obsoletion_candidate
synonym: "activation of transporter activity" NARROW []
synonym: "stimulation of transporter activity" NARROW []
synonym: "up regulation of transporter activity" EXACT []
synonym: "up-regulation of transporter activity" EXACT []
synonym: "upregulation of transporter activity" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0005215 ! positively regulates transporter activity
relationship: RO:0002213 GO:0005215 ! positively regulates transporter activity

[Term]
id: GO:0032413
name: negative regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of ion transporter activity" EXACT []
synonym: "down-regulation of ion transporter activity" EXACT []
synonym: "downregulation of ion transporter activity" EXACT []
synonym: "inhibition of ion transporter activity" NARROW []
synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity
relationship: RO:0002212 GO:0015075 ! negatively regulates monoatomic ion transmembrane transporter activity

[Term]
id: GO:0032414
name: positive regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_obsoletion_candidate
synonym: "activation of ion transporter activity" NARROW []
synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb]
synonym: "stimulation of ion transporter activity" NARROW []
synonym: "up regulation of ion transporter activity" EXACT []
synonym: "up-regulation of ion transporter activity" EXACT []
synonym: "upregulation of ion transporter activity" EXACT []
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity
relationship: RO:0002213 GO:0015075 ! positively regulates monoatomic ion transmembrane transporter activity

[Term]
id: GO:0032418
name: lysosome localization
namespace: biological_process
def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "lysosome localisation" EXACT [GOC:mah]
is_a: GO:1990849 ! vacuolar localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005764 ! has primary input lysosome
relationship: RO:0004009 GO:0005764 ! has primary input lysosome

[Term]
id: GO:0032432
name: actin filament bundle
namespace: cellular_component
def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]
synonym: "actin cable" RELATED [GOC:mah]
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton
relationship: BFO:0000051 GO:0005884 ! has part actin filament

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
synonym: "single-multicellular organism process" RELATED []
is_a: GO:0008150 ! biological_process
creation_date: 2012-09-19T16:07:47Z

[Term]
id: GO:0032502
name: developmental process
namespace: biological_process
alt_id: GO:0044767
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_pir
synonym: "development" NARROW []
synonym: "single-organism developmental process" RELATED []
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
created_by: jl
creation_date: 2012-12-19T12:21:31Z

[Term]
id: GO:0032507
name: maintenance of protein location in cell
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb]
is_a: GO:0045185 ! maintenance of protein location
is_a: GO:0051651 ! maintenance of location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms

[Term]
id: GO:0032528
name: microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah]
synonym: "microvillus organisation" EXACT [GOC:mah]
synonym: "microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005902 ! results in organization of microvillus
relationship: RO:0002592 GO:0005902 ! results in organization of microvillus

[Term]
id: GO:0032530
name: regulation of microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah]
synonym: "regulation of microvillus organisation" EXACT [GOC:mah]
synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032528 ! regulates microvillus organization
relationship: RO:0002211 GO:0032528 ! regulates microvillus organization

[Term]
id: GO:0032534
name: regulation of microvillus assembly
namespace: biological_process
def: "A process that modulates the formation of a microvillus." [GOC:mah]
synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030033 ! regulates microvillus assembly
relationship: RO:0002211 GO:0030033 ! regulates microvillus assembly

[Term]
id: GO:0032543
name: mitochondrial translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
subset: goslim_yeast
synonym: "mitochondrial protein anabolism" EXACT []
synonym: "mitochondrial protein biosynthesis" EXACT []
synonym: "mitochondrial protein formation" EXACT []
synonym: "mitochondrial protein synthesis" EXACT []
synonym: "mitochondrial protein translation" EXACT []
xref: Reactome:R-HSA-5368287 "Mitochondrial translation"
is_a: GO:0006412 ! translation
intersection_of: GO:0006412 ! translation
intersection_of: BFO:0000050 GO:0140053 ! part of mitochondrial gene expression
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0140053 ! part of mitochondrial gene expression

[Term]
id: GO:0032544
name: plastid translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
synonym: "plastid protein anabolism" EXACT []
synonym: "plastid protein biosynthesis" EXACT []
synonym: "plastid protein formation" EXACT []
synonym: "plastid protein synthesis" EXACT []
synonym: "plastid protein translation" EXACT []
is_a: GO:0006412 ! translation
is_a: GO:0009657 ! plastid organization
intersection_of: GO:0006412 ! translation
intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid
relationship: BFO:0000066 GO:0009536 ! occurs in plastid

[Term]
id: GO:0032589
name: neuron projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0043005 ! bounding layer of neuron projection
relationship: RO:0002007 GO:0043005 ! bounding layer of neuron projection

[Term]
id: GO:0032590
name: dendrite membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0030425 ! bounding layer of dendrite
relationship: RO:0002007 GO:0030425 ! bounding layer of dendrite

[Term]
id: GO:0032594
name: protein transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah]
synonym: "protein translocation within membrane" EXACT []
synonym: "receptor translocation within membrane" NARROW []
synonym: "receptor transport within lipid bilayer" NARROW []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0015031 ! protein transport
intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane
relationship: BFO:0000066 GO:0016020 ! occurs in membrane

[Term]
id: GO:0032774
name: RNA biosynthetic process
namespace: biological_process
alt_id: GO:0062103
def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
subset: gocheck_do_not_annotate
synonym: "double-stranded RNA biosynthesis" NARROW []
synonym: "double-stranded RNA biosynthetic process" NARROW []
synonym: "dsRNA biosynthesis" NARROW []
synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl]
synonym: "RNA anabolism" EXACT []
synonym: "RNA biosynthesis" EXACT []
synonym: "RNA formation" EXACT []
synonym: "RNA synthesis" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0141187 ! nucleic acid biosynthetic process
intersection_of: GO:0009059 ! macromolecule biosynthetic process
intersection_of: RO:0004008 CHEBI:33697 ! has primary output ribonucleic acid
relationship: RO:0004008 CHEBI:33697 ! has primary output ribonucleic acid

[Term]
id: GO:0032787
name: monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]
subset: goslim_yeast
synonym: "monocarboxylate metabolic process" EXACT []
synonym: "monocarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:35757 ! has primary input or output monocarboxylic acid anion
relationship: RO:0004007 CHEBI:35757 ! has primary input or output monocarboxylic acid anion

[Term]
id: GO:0032790
name: ribosome disassembly
namespace: biological_process
def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk]
synonym: "ribosome dissociation factor" RELATED []
synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391]
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005840 ! results in disassembly of ribosome
relationship: RO:0002590 GO:0005840 ! results in disassembly of ribosome

[Term]
id: GO:0032838
name: plasma membrane bounded cell projection cytoplasm
namespace: cellular_component
def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah]
is_a: GO:0099568 ! cytoplasmic region
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0120025 ! part of plasma membrane bounded cell projection
relationship: BFO:0000050 GO:0120025 ! part of plasma membrane bounded cell projection

[Term]
id: GO:0032839
name: dendrite cytoplasm
namespace: cellular_component
def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah]
synonym: "dendritic cytoplasm" EXACT []
is_a: GO:0120111 ! neuron projection cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0030425 ! part of dendrite
relationship: BFO:0000050 GO:0030425 ! part of dendrite

[Term]
id: GO:0032870
name: cellular response to hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]
is_a: GO:0009725 ! response to hormone
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0032871
name: regulation of karyogamy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah]
is_a: GO:1903353 ! regulation of nucleus organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000741 ! regulates karyogamy
relationship: RO:0002211 GO:0000741 ! regulates karyogamy

[Term]
id: GO:0032878
name: regulation of establishment or maintenance of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity
relationship: RO:0002211 GO:0007163 ! regulates establishment or maintenance of cell polarity

[Term]
id: GO:0032879
name: regulation of localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "regulation of localisation" EXACT [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051179 ! regulates localization
relationship: RO:0002211 GO:0051179 ! regulates localization

[Term]
id: GO:0032880
name: regulation of protein localization
namespace: biological_process
alt_id: GO:1903827
def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_chembl
synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein localization" EXACT []
synonym: "regulation of protein localisation" EXACT [GOC:mah]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008104 ! regulates intracellular protein localization
relationship: RO:0002211 GO:0008104 ! regulates intracellular protein localization
created_by: jl
creation_date: 2015-01-20T14:32:14Z

[Term]
id: GO:0032881
name: regulation of polysaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process
relationship: RO:0002211 GO:0005976 ! regulates polysaccharide metabolic process

[Term]
id: GO:0032885
name: regulation of polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process
relationship: RO:0002211 GO:0000271 ! regulates polysaccharide biosynthetic process

[Term]
id: GO:0032886
name: regulation of microtubule-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007017 ! regulates microtubule-based process
relationship: RO:0002211 GO:0007017 ! regulates microtubule-based process

[Term]
id: GO:0032890
name: regulation of organic acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015849 ! regulates organic acid transport
relationship: RO:0002211 GO:0015849 ! regulates organic acid transport

[Term]
id: GO:0032891
name: negative regulation of organic acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of organic acid transport" EXACT []
synonym: "down-regulation of organic acid transport" EXACT []
synonym: "downregulation of organic acid transport" EXACT []
synonym: "inhibition of organic acid transport" NARROW []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0015849 ! negatively regulates organic acid transport
relationship: RO:0002212 GO:0015849 ! negatively regulates organic acid transport

[Term]
id: GO:0032892
name: positive regulation of organic acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of organic acid transport" NARROW []
synonym: "stimulation of organic acid transport" NARROW []
synonym: "up regulation of organic acid transport" EXACT []
synonym: "up-regulation of organic acid transport" EXACT []
synonym: "upregulation of organic acid transport" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0015849 ! positively regulates organic acid transport
relationship: RO:0002213 GO:0015849 ! positively regulates organic acid transport

[Term]
id: GO:0032938
name: negative regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0043556 ! regulation of translation in response to oxidative stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress
intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation

[Term]
id: GO:0032939
name: positive regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "activation of translation in response to oxidative stress" NARROW []
synonym: "stimulation of translation in response to oxidative stress" NARROW []
synonym: "up regulation of translation in response to oxidative stress" EXACT []
synonym: "up-regulation of translation in response to oxidative stress" EXACT []
synonym: "upregulation of translation in response to oxidative stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress
intersection_of: RO:0002213 GO:0006412 ! positively regulates translation
relationship: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress

[Term]
id: GO:0032940
name: secretion by cell
namespace: biological_process
def: "The controlled release of a substance by a cell." [GOC:mah]
synonym: "cellular secretion" EXACT []
xref: Wikipedia:Secretion
is_a: GO:0046903 ! secretion
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0032941
name: secretion by tissue
namespace: biological_process
def: "The controlled release of a substance by a tissue." [GOC:mah]
synonym: "expulsion of gland contents" RELATED [GOC:mah]
synonym: "tissue secretion" EXACT []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032943
name: mononuclear cell proliferation
namespace: biological_process
def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
synonym: "PBMC proliferation" NARROW []
synonym: "peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070661 ! leukocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000842 ! acts on population of mononuclear leukocyte
relationship: RO:0012003 CL:0000842 ! acts on population of mononuclear leukocyte

[Term]
id: GO:0032944
name: regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "regulation of PBMC proliferation" NARROW []
synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032943 ! regulates mononuclear cell proliferation
relationship: RO:0002211 GO:0032943 ! regulates mononuclear cell proliferation

[Term]
id: GO:0032945
name: negative regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "negative regulation of PBMC proliferation" NARROW []
synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032943 ! negatively regulates mononuclear cell proliferation
relationship: RO:0002212 GO:0032943 ! negatively regulates mononuclear cell proliferation

[Term]
id: GO:0032946
name: positive regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "activation of mononuclear cell proliferation" NARROW []
synonym: "positive regulation of PBMC proliferation" NARROW []
synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW []
synonym: "stimulation of mononuclear cell proliferation" NARROW []
synonym: "up regulation of mononuclear cell proliferation" EXACT []
synonym: "up-regulation of mononuclear cell proliferation" EXACT []
synonym: "upregulation of mononuclear cell proliferation" EXACT []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032943 ! positively regulates mononuclear cell proliferation
relationship: RO:0002213 GO:0032943 ! positively regulates mononuclear cell proliferation

[Term]
id: GO:0032956
name: regulation of actin cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032970 ! regulation of actin filament-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization
relationship: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization

[Term]
id: GO:0032963
name: collagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 GO:0005581 ! has primary input or output collagen trimer
relationship: RO:0004007 GO:0005581 ! has primary input or output collagen trimer

[Term]
id: GO:0032964
name: collagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen anabolism" EXACT []
synonym: "collagen biosynthesis" EXACT []
synonym: "collagen formation" EXACT []
synonym: "collagen synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0032963 ! collagen metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 GO:0005581 ! has primary output collagen trimer
relationship: RO:0004008 GO:0005581 ! has primary output collagen trimer

[Term]
id: GO:0032965
name: regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "regulation of collagen anabolism" EXACT []
synonym: "regulation of collagen biosynthesis" EXACT []
synonym: "regulation of collagen formation" EXACT []
synonym: "regulation of collagen synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process
relationship: RO:0002211 GO:0032964 ! regulates collagen biosynthetic process

[Term]
id: GO:0032966
name: negative regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "negative regulation of collagen anabolism" EXACT []
synonym: "negative regulation of collagen biosynthesis" EXACT []
synonym: "negative regulation of collagen formation" EXACT []
synonym: "negative regulation of collagen synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process
relationship: RO:0002212 GO:0032964 ! negatively regulates collagen biosynthetic process

[Term]
id: GO:0032967
name: positive regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "positive regulation of collagen anabolism" EXACT []
synonym: "positive regulation of collagen biosynthesis" EXACT []
synonym: "positive regulation of collagen formation" EXACT []
synonym: "positive regulation of collagen synthesis" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process
relationship: RO:0002213 GO:0032964 ! positively regulates collagen biosynthetic process

[Term]
id: GO:0032970
name: regulation of actin filament-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030029 ! regulates actin filament-based process
relationship: RO:0002211 GO:0030029 ! regulates actin filament-based process

[Term]
id: GO:0032973
name: amino acid export across plasma membrane
namespace: biological_process
def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl]
synonym: "amino acid efflux" EXACT []
synonym: "amino acid export" BROAD []
synonym: "amino acid transmembrane export" BROAD []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0140115 ! export across plasma membrane
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
creation_date: 2012-11-14T14:27:40Z

[Term]
id: GO:0032974
name: amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
synonym: "amino acid efflux from vacuole" EXACT []
synonym: "vacuolar amino acid export" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0002338 GO:0005775 ! has target start location vacuolar lumen
relationship: RO:0002339 GO:0005829 ! has target end location cytosol

[Term]
id: GO:0032975
name: amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
synonym: "vacuolar amino acid import" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0034486 ! vacuolar transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005775 ! has target end location vacuolar lumen

[Term]
id: GO:0032984
name: protein-containing complex disassembly
namespace: biological_process
alt_id: GO:0034623
alt_id: GO:0043241
alt_id: GO:0043624
def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah]
synonym: "cellular macromolecule complex disassembly" RELATED []
synonym: "cellular protein complex disassembly" RELATED []
synonym: "macromolecule complex disassembly" RELATED []
synonym: "protein complex disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex
relationship: RO:0002590 GO:0032991 ! results in disassembly of protein-containing complex

[Term]
id: GO:0032988
name: protein-RNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah]
synonym: "ribonucleoprotein complex disassembly" EXACT []
synonym: "RNA-protein complex disassembly" EXACT []
synonym: "RNP complex disassembly" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071826 ! protein-RNA complex organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex
relationship: RO:0002590 GO:1990904 ! results in disassembly of ribonucleoprotein complex

[Term]
id: GO:0032989
name: cellular anatomical entity morphogenesis
namespace: biological_process
def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
synonym: "cellular component morphogenesis" EXACT []
synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0032991
name: protein-containing complex
namespace: cellular_component
alt_id: GO:0043234
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "macromolecular complex" EXACT []
synonym: "macromolecule complex" EXACT []
synonym: "protein complex" NARROW []
synonym: "protein containing complex" EXACT []
synonym: "protein-protein complex" NARROW []
is_a: GO:0005575 ! cellular_component
disjoint_from: GO:0044423 ! virion component
disjoint_from: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000051 PR:000000001 ! has part protein

[Term]
id: GO:0033002
name: muscle cell proliferation
namespace: biological_process
def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah]
synonym: "myocyte proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000187 ! acts on population of muscle cell
relationship: RO:0012003 CL:0000187 ! acts on population of muscle cell

[Term]
id: GO:0033028
name: myeloid cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093]
synonym: "apoptosis of myeloid cells" EXACT []
synonym: "myeloid cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000763 ! occurs in myeloid cell
relationship: BFO:0000066 CL:0000763 ! occurs in myeloid cell

[Term]
id: GO:0033032
name: regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process
relationship: RO:0002211 GO:0033028 ! regulates myeloid cell apoptotic process

[Term]
id: GO:0033033
name: negative regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of myeloid cell apoptosis" EXACT []
synonym: "down-regulation of myeloid cell apoptosis" EXACT []
synonym: "downregulation of myeloid cell apoptosis" EXACT []
synonym: "inhibition of myeloid cell apoptosis" NARROW []
synonym: "negative regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process
relationship: RO:0002212 GO:0033028 ! negatively regulates myeloid cell apoptotic process

[Term]
id: GO:0033034
name: positive regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of myeloid cell apoptosis" NARROW []
synonym: "positive regulation of myeloid cell apoptosis" NARROW []
synonym: "stimulation of myeloid cell apoptosis" NARROW []
synonym: "up regulation of myeloid cell apoptosis" EXACT []
synonym: "up-regulation of myeloid cell apoptosis" EXACT []
synonym: "upregulation of myeloid cell apoptosis" EXACT []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process
relationship: RO:0002213 GO:0033028 ! positively regulates myeloid cell apoptotic process

[Term]
id: GO:0033036
name: macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_flybase_ribbon
synonym: "macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0033037
name: polysaccharide localization
namespace: biological_process
def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "polysaccharide localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
intersection_of: GO:0033036 ! macromolecule localization
intersection_of: RO:0004009 CHEBI:18154 ! has primary input polysaccharide
relationship: RO:0004009 CHEBI:18154 ! has primary input polysaccharide

[Term]
id: GO:0033043
name: regulation of organelle organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_yeast
synonym: "regulation of organelle organisation" EXACT [GOC:mah]
synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006996 ! regulates organelle organization
relationship: RO:0002211 GO:0006996 ! regulates organelle organization

[Term]
id: GO:0033044
name: regulation of chromosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]
synonym: "regulation of chromosome organisation" EXACT [GOC:mah]
synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051276 ! regulates chromosome organization
relationship: RO:0002211 GO:0051276 ! regulates chromosome organization

[Term]
id: GO:0033045
name: regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000819 ! regulates sister chromatid segregation
relationship: RO:0002211 GO:0000819 ! regulates sister chromatid segregation

[Term]
id: GO:0033046
name: negative regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation
relationship: RO:0002212 GO:0000819 ! negatively regulates sister chromatid segregation

[Term]
id: GO:0033047
name: regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033045 ! regulation of sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation
relationship: RO:0002211 GO:0000070 ! regulates mitotic sister chromatid segregation

[Term]
id: GO:0033048
name: negative regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033046 ! negative regulation of sister chromatid segregation
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation
relationship: RO:0002212 GO:0000070 ! negatively regulates mitotic sister chromatid segregation

[Term]
id: GO:0033059
name: cellular pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]
is_a: GO:0009987 ! cellular process
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033157
name: regulation of intracellular protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051223 ! regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006886 ! regulates intracellular protein transport
relationship: RO:0002211 GO:0006886 ! regulates intracellular protein transport

[Term]
id: GO:0033218
name: amide binding
namespace: molecular_function
def: "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]
subset: goslim_pir
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide
relationship: RO:0004009 CHEBI:32988 ! has primary input amide

[Term]
id: GO:0033238
name: regulation of amine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah]
synonym: "regulation of amine metabolism" EXACT []
synonym: "regulation of cellular amine metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009308 ! regulates amine metabolic process
relationship: RO:0002211 GO:0009308 ! regulates amine metabolic process

[Term]
id: GO:0033239
name: negative regulation of amine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "negative regulation of amine metabolism" EXACT []
synonym: "negative regulation of cellular amine metabolic process" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process
relationship: RO:0002212 GO:0009308 ! negatively regulates amine metabolic process

[Term]
id: GO:0033240
name: positive regulation of amine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "positive regulation of amine metabolism" EXACT []
synonym: "positive regulation of cellular amine metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009308 ! positively regulates amine metabolic process
relationship: RO:0002213 GO:0009308 ! positively regulates amine metabolic process

[Term]
id: GO:0033241
name: regulation of amine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "regulation of amine breakdown" EXACT []
synonym: "regulation of amine catabolism" EXACT []
synonym: "regulation of amine degradation" EXACT []
synonym: "regulation of cellular amine catabolic process" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009310 ! regulates amine catabolic process
relationship: RO:0002211 GO:0009310 ! regulates amine catabolic process

[Term]
id: GO:0033242
name: negative regulation of amine catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "negative regulation of amine breakdown" EXACT []
synonym: "negative regulation of amine catabolism" EXACT []
synonym: "negative regulation of amine degradation" EXACT []
synonym: "negative regulation of cellular amine catabolic process" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process
relationship: RO:0002212 GO:0009310 ! negatively regulates amine catabolic process

[Term]
id: GO:0033243
name: positive regulation of amine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "positive regulation of amine breakdown" EXACT []
synonym: "positive regulation of amine catabolism" EXACT []
synonym: "positive regulation of amine degradation" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009310 ! positively regulates amine catabolic process
relationship: RO:0002213 GO:0009310 ! positively regulates amine catabolic process

[Term]
id: GO:0033278
name: cell proliferation in midbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf]
synonym: "cell proliferation in mesencephalon" EXACT []
synonym: "mesencepahalic cell proliferation" RELATED []
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000066 UBERON:0001891 ! occurs in midbrain
relationship: BFO:0000050 GO:0030901 ! part of midbrain development
relationship: BFO:0000066 UBERON:0001891 ! occurs in midbrain

[Term]
id: GO:0033293
name: monocarboxylic acid binding
namespace: molecular_function
def: "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah]
is_a: GO:0031406 ! carboxylic acid binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion
relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion

[Term]
id: GO:0033326
name: cerebrospinal fluid secretion
namespace: biological_process
def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, PMID:10716451]
synonym: "CSF secretion" EXACT []
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue

[Term]
id: GO:0033363
name: secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "secretory granule organisation" EXACT [GOC:mah]
synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule
relationship: BFO:0000050 GO:0010256 ! part of endomembrane system organization
relationship: RO:0002592 GO:0030141 ! results in organization of secretory granule

[Term]
id: GO:0033365
name: protein localization to organelle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "protein localisation to organelle" EXACT [GOC:mah]
synonym: "protein localization in organelle" EXACT [GOC:mah]
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0043226 ! has target end location organelle
relationship: RO:0002339 GO:0043226 ! has target end location organelle

[Term]
id: GO:0033366
name: protein localization to secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah]
synonym: "protein localisation in secretory granule" EXACT [GOC:mah]
synonym: "protein localization in secretory granule" EXACT []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule
relationship: RO:0002339 GO:0030141 ! has target end location secretory granule

[Term]
id: GO:0033371
name: T cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "T cell secretory granule organisation" EXACT [GOC:mah]
synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah]
synonym: "T lymphocyte secretory granule organization" EXACT []
synonym: "T-cell secretory granule organization" EXACT []
synonym: "T-lymphocyte secretory granule maturation" RELATED []
synonym: "T-lymphocyte secretory granule organization" EXACT []
is_a: GO:0033363 ! secretory granule organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell
intersection_of: RO:0002592 GO:0030141 ! results in organization of secretory granule
relationship: BFO:0000066 CL:0000084 ! occurs in T cell

[Term]
id: GO:0033504
name: floor plate development
namespace: biological_process
def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003306 ! results in development of floor plate of neural tube
relationship: BFO:0000050 GO:0021915 ! part of neural tube development
relationship: RO:0002296 UBERON:0003306 ! results in development of floor plate of neural tube

[Term]
id: GO:0033505
name: floor plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003079 ! results in morphogenesis of floor plate
relationship: BFO:0000050 GO:0033504 ! part of floor plate development
relationship: RO:0002298 UBERON:0003079 ! results in morphogenesis of floor plate

[Term]
id: GO:0033554
name: cellular response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
xref: Reactome:R-HSA-2262752 "Cellular responses to stress"
is_a: GO:0006950 ! response to stress
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0033602
name: negative regulation of dopamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "down regulation of dopamine secretion" EXACT []
synonym: "down-regulation of dopamine secretion" EXACT []
synonym: "downregulation of dopamine secretion" EXACT []
synonym: "inhibition of dopamine secretion" NARROW []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014046 ! negatively regulates dopamine secretion
relationship: RO:0002212 GO:0014046 ! negatively regulates dopamine secretion

[Term]
id: GO:0033603
name: positive regulation of dopamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "activation of dopamine secretion" NARROW []
synonym: "stimulation of dopamine secretion" NARROW []
synonym: "up regulation of dopamine secretion" EXACT []
synonym: "up-regulation of dopamine secretion" EXACT []
synonym: "upregulation of dopamine secretion" EXACT []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014046 ! positively regulates dopamine secretion
relationship: RO:0002213 GO:0014046 ! positively regulates dopamine secretion

[Term]
id: GO:0033604
name: negative regulation of catecholamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "down regulation of catecholamine secretion" EXACT []
synonym: "down-regulation of catecholamine secretion" EXACT []
synonym: "downregulation of catecholamine secretion" EXACT []
synonym: "inhibition of catecholamine secretion" NARROW []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion
relationship: RO:0002212 GO:0050432 ! negatively regulates catecholamine secretion

[Term]
id: GO:0033605
name: positive regulation of catecholamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "activation of catecholamine secretion" NARROW []
synonym: "stimulation of catecholamine secretion" NARROW []
synonym: "up regulation of catecholamine secretion" EXACT []
synonym: "up-regulation of catecholamine secretion" EXACT []
synonym: "upregulation of catecholamine secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion
relationship: RO:0002213 GO:0050432 ! positively regulates catecholamine secretion

[Term]
id: GO:0033684
name: regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
is_a: GO:0032276 ! regulation of gonadotropin secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032275 ! regulates luteinizing hormone secretion
relationship: RO:0002211 GO:0032275 ! regulates luteinizing hormone secretion

[Term]
id: GO:0033685
name: negative regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "down regulation of luteinizing hormone secretion" EXACT []
synonym: "down-regulation of luteinizing hormone secretion" EXACT []
synonym: "downregulation of luteinizing hormone secretion" EXACT []
synonym: "inhibition of luteinizing hormone secretion" NARROW []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032275 ! negatively regulates luteinizing hormone secretion
relationship: RO:0002212 GO:0032275 ! negatively regulates luteinizing hormone secretion

[Term]
id: GO:0033686
name: positive regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "activation of luteinizing hormone secretion" NARROW []
synonym: "stimulation of luteinizing hormone secretion" NARROW []
synonym: "up regulation of luteinizing hormone secretion" EXACT []
synonym: "up-regulation of luteinizing hormone secretion" EXACT []
synonym: "upregulation of luteinizing hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032275 ! positively regulates luteinizing hormone secretion
relationship: RO:0002213 GO:0032275 ! positively regulates luteinizing hormone secretion

[Term]
id: GO:0033696
name: heterochromatin boundary formation
namespace: biological_process
def: "A process that forms a boundary that limits the spreading of heterochromatin along a chromosome." [GOC:mah]
synonym: "maintenance of heterochromatin boundaries" RELATED []
synonym: "negative regulation of extent of heterochromatin assembly" RELATED []
synonym: "negative regulation of extent of heterochromatin formation" RELATED []
synonym: "negative regulation of heterochromatin spreading" RELATED []
synonym: "regulation of extent of heterochromatin assembly" RELATED []
synonym: "regulation of extent of heterochromatin formation" EXACT []
synonym: "regulation of heterochromatin spreading" RELATED []
is_a: GO:0070828 ! heterochromatin organization
relationship: BFO:0000050 GO:0031507 ! part of heterochromatin formation

[Term]
id: GO:0033750
name: ribosome localization
namespace: biological_process
def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "establishment of ribosome localisation" RELATED []
synonym: "establishment of ribosome localization" RELATED []
synonym: "ribosome localisation" RELATED []
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome
relationship: RO:0004009 GO:0005840 ! has primary input ribosome

[Term]
id: GO:0033993
name: response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0034050
name: symbiont-induced defense-related programmed cell death
namespace: biological_process
def: "Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules." [GOC:pamgo_curators]
comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'symbiont-mediated activation of host programmed cell death' ; GO:0052042'.
synonym: "host programmed cell death induced by symbiont" EXACT []
synonym: "programmed cell death induced by symbiont" EXACT []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0034067
name: protein localization to Golgi apparatus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]
synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah]
synonym: "establishment of protein localization in Golgi" NARROW []
synonym: "establishment of protein localization to Golgi" NARROW []
synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah]
synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah]
synonym: "protein localization in Golgi apparatus" EXACT []
synonym: "protein targeting to Golgi" RELATED []
synonym: "protein-Golgi targeting" RELATED []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus
relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus
creation_date: 2011-02-14T02:26:36Z

[Term]
id: GO:0034097
name: response to cytokine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]
synonym: "response to cytokine stimulus" EXACT [GOC:dos]
xref: Reactome:R-HSA-9645135 "STAT5 Activation"
is_a: GO:1901652 ! response to peptide

[Term]
id: GO:0034101
name: erythrocyte homeostasis
namespace: biological_process
def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]
synonym: "RBC homeostasis" EXACT [CL:0000232]
synonym: "red blood cell homeostasis" EXACT [CL:0000232]
is_a: GO:0002262 ! myeloid cell homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000232 ! acts on population of erythrocyte
relationship: RO:0012003 CL:0000232 ! acts on population of erythrocyte

[Term]
id: GO:0034103
name: regulation of tissue remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add]
synonym: "regulation of tissue remodelling" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048771 ! regulates tissue remodeling
relationship: RO:0002211 GO:0048771 ! regulates tissue remodeling

[Term]
id: GO:0034104
name: negative regulation of tissue remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add]
synonym: "negative regulation of tissue remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048771 ! negatively regulates tissue remodeling
relationship: RO:0002212 GO:0048771 ! negatively regulates tissue remodeling

[Term]
id: GO:0034105
name: positive regulation of tissue remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add]
synonym: "positive regulation of tissue remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048771 ! positively regulates tissue remodeling
relationship: RO:0002213 GO:0048771 ! positively regulates tissue remodeling

[Term]
id: GO:0034219
name: carbohydrate transmembrane transport
namespace: biological_process
def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbohydrate membrane transport" EXACT []
synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate

[Term]
id: GO:0034220
name: monoatomic ion transmembrane transport
namespace: biological_process
def: "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW []
synonym: "ion membrane transport" EXACT []
synonym: "ion transmembrane transport" BROAD []
synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
xref: Reactome:R-HSA-983712 "Ion channel transport"
is_a: GO:0006811 ! monoatomic ion transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:24867 ! has primary input monoatomic ion

[Term]
id: GO:0034242
name: negative regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion
relationship: RO:0002212 GO:0000768 ! negatively regulates syncytium formation by plasma membrane fusion

[Term]
id: GO:0034248
name: regulation of amide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "regulation of amide metabolism" EXACT []
synonym: "regulation of cellular amide metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043603 ! regulates amide metabolic process
relationship: RO:0002211 GO:0043603 ! regulates amide metabolic process

[Term]
id: GO:0034249
name: negative regulation of amide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "negative regulation of amide metabolism" EXACT []
synonym: "negative regulation of cellular amide metabolic process" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process
relationship: RO:0002212 GO:0043603 ! negatively regulates amide metabolic process

[Term]
id: GO:0034250
name: positive regulation of amide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "positive regulation of amide metabolism" EXACT []
synonym: "positive regulation of cellular amide metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043603 ! positively regulates amide metabolic process
relationship: RO:0002213 GO:0043603 ! positively regulates amide metabolic process

[Term]
id: GO:0034251
name: regulation of amide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "regulation of amide breakdown" EXACT []
synonym: "regulation of amide catabolism" EXACT []
synonym: "regulation of amide degradation" EXACT []
synonym: "regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043605 ! regulates amide catabolic process
relationship: RO:0002211 GO:0043605 ! regulates amide catabolic process

[Term]
id: GO:0034252
name: negative regulation of amide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "negative regulation of amide breakdown" EXACT []
synonym: "negative regulation of amide catabolism" EXACT []
synonym: "negative regulation of amide degradation" RELATED []
synonym: "negative regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0034251 ! regulation of amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process
relationship: RO:0002212 GO:0043605 ! negatively regulates amide catabolic process

[Term]
id: GO:0034253
name: positive regulation of amide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "positive regulation of amide breakdown" EXACT []
synonym: "positive regulation of amide catabolism" EXACT []
synonym: "positive regulation of amide degradation" RELATED []
synonym: "positive regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0034251 ! regulation of amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043605 ! positively regulates amide catabolic process
relationship: RO:0002213 GO:0043605 ! positively regulates amide catabolic process

[Term]
id: GO:0034293
name: sexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of meiosis." [GOC:mah]
synonym: "meiotic spore formation" EXACT []
synonym: "meiotic sporulation" EXACT []
synonym: "sexual spore formation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0043934 ! sporulation
intersection_of: GO:0043934 ! sporulation
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle
relationship: BFO:0000050 GO:0051321 ! part of meiotic cell cycle

[Term]
id: GO:0034301
name: endospore formation
namespace: biological_process
def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034305
name: regulation of asexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah]
synonym: "regulation of asexual spore formation" EXACT []
synonym: "regulation of mitotic spore formation" EXACT []
synonym: "regulation of mitotic sporulation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:1903664 ! regulation of asexual reproduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030436 ! regulates asexual sporulation
relationship: RO:0002211 GO:0030436 ! regulates asexual sporulation

[Term]
id: GO:0034306
name: regulation of sexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" RELATED []
synonym: "regulation of meiotic spore formation" EXACT []
synonym: "regulation of meiotic sporulation" EXACT []
synonym: "regulation of sexual spore formation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051445 ! regulation of meiotic cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034293 ! regulates sexual sporulation
relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi
relationship: RO:0002211 GO:0034293 ! regulates sexual sporulation

[Term]
id: GO:0034308
name: primary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]
synonym: "monohydric alcohol metabolic process" EXACT []
synonym: "primary alcohol metabolism" EXACT [GOC:mah]
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0034309
name: primary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]
synonym: "monohydric alcohol biosynthetic process" EXACT []
synonym: "primary alcohol anabolism" EXACT [GOC:mah]
synonym: "primary alcohol biosynthesis" EXACT [GOC:mah]
synonym: "primary alcohol formation" EXACT [GOC:mah]
synonym: "primary alcohol synthesis" EXACT [GOC:mah]
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0034329
name: cell junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]
xref: Reactome:R-HSA-446728 "Cell junction organization"
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0030054 ! results in assembly of cell junction
relationship: RO:0002588 GO:0030054 ! results in assembly of cell junction

[Term]
id: GO:0034330
name: cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "cell junction assembly and maintenance" EXACT []
synonym: "cell junction biogenesis" RELATED []
synonym: "cell junction organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0030054 ! results in organization of cell junction
relationship: RO:0002592 GO:0030054 ! results in organization of cell junction

[Term]
id: GO:0034349
name: glial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart]
synonym: "apoptosis of glia" EXACT []
synonym: "apoptosis of glial cells" EXACT []
synonym: "glia apoptosis" EXACT []
synonym: "glia programmed cell death by apoptosis" EXACT []
synonym: "glial cell apoptosis" NARROW []
synonym: "glial cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of glia by apoptosis" EXACT []
synonym: "programmed cell death of glial cells by apoptosis" EXACT []
synonym: "programmed cell death, glia" EXACT []
synonym: "programmed cell death, glial cells" EXACT []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000125 ! occurs in glial cell
relationship: BFO:0000066 CL:0000125 ! occurs in glial cell

[Term]
id: GO:0034350
name: regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of glial cell apoptosis" RELATED []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process
relationship: RO:0002211 GO:0034349 ! regulates glial cell apoptotic process

[Term]
id: GO:0034351
name: negative regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "down regulation of glial cell apoptosis" EXACT []
synonym: "down-regulation of glial cell apoptosis" EXACT []
synonym: "downregulation of glial cell apoptosis" EXACT []
synonym: "inhibition of glial cell apoptosis" NARROW []
synonym: "negative regulation of glial cell apoptosis" NARROW []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process
relationship: RO:0002212 GO:0034349 ! negatively regulates glial cell apoptotic process

[Term]
id: GO:0034352
name: positive regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "activation of glial cell apoptosis" NARROW []
synonym: "positive regulation of glial cell apoptosis" NARROW []
synonym: "stimulation of glial cell apoptosis" NARROW []
synonym: "up regulation of glial cell apoptosis" EXACT []
synonym: "up-regulation of glial cell apoptosis" EXACT []
synonym: "upregulation of glial cell apoptosis" EXACT []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process
relationship: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process

[Term]
id: GO:0034390
name: smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]
synonym: "apoptosis of smooth muscle cells" EXACT []
synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT []
synonym: "programmed cell death, smooth muscle cells" EXACT []
synonym: "SMC apoptosis" EXACT []
synonym: "smooth muscle cell apoptosis" NARROW []
synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT []
is_a: GO:0010657 ! muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell
relationship: BFO:0000066 CL:0000192 ! occurs in smooth muscle cell

[Term]
id: GO:0034391
name: regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "regulation of SMC apoptosis" EXACT []
synonym: "regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process
relationship: RO:0002211 GO:0034390 ! regulates smooth muscle cell apoptotic process

[Term]
id: GO:0034392
name: negative regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "down regulation of smooth muscle cell apoptosis" EXACT []
synonym: "down-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "downregulation of smooth muscle cell apoptosis" EXACT []
synonym: "inhibition of smooth muscle cell apoptosis" NARROW []
synonym: "negative regulation of SMC apoptosis" EXACT []
synonym: "negative regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process
relationship: RO:0002212 GO:0034390 ! negatively regulates smooth muscle cell apoptotic process

[Term]
id: GO:0034393
name: positive regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "activation of smooth muscle cell apoptosis" NARROW []
synonym: "positive regulation of SMC apoptosis" EXACT []
synonym: "positive regulation of smooth muscle cell apoptosis" NARROW []
synonym: "stimulation of smooth muscle cell apoptosis" NARROW []
synonym: "up regulation of smooth muscle cell apoptosis" EXACT []
synonym: "up-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "upregulation of smooth muscle cell apoptosis" EXACT []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process
relationship: RO:0002213 GO:0034390 ! positively regulates smooth muscle cell apoptotic process

[Term]
id: GO:0034436
name: glycoprotein transport
namespace: biological_process
def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0015031 ! protein transport
is_a: GO:1901264 ! carbohydrate derivative transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:17089 ! has primary input
relationship: RO:0004009 CHEBI:17089 ! has primary input

[Term]
id: GO:0034486
name: vacuolar transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0002344 GO:0005773 ! results in transport to from or in vacuole
relationship: RO:0002344 GO:0005773 ! results in transport to from or in vacuole

[Term]
id: GO:0034487
name: vacuolar amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar amino acid membrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane

[Term]
id: GO:0034489
name: neutral amino acid transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
intersection_of: GO:0015804 ! neutral amino acid transport
intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0034491
name: neutral amino acid transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
intersection_of: GO:0015804 ! neutral amino acid transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0034502
name: protein localization to chromosome
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]
synonym: "condensin localization to chromosome" NARROW []
synonym: "protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome
relationship: RO:0002339 GO:0005694 ! has target end location chromosome

[Term]
id: GO:0034504
name: protein localization to nucleus
namespace: biological_process
alt_id: GO:0044744
def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]
synonym: "protein localisation to nucleus" EXACT [GOC:mah]
synonym: "protein localization in cell nucleus" EXACT []
synonym: "protein localization in nucleus" EXACT [GOC:mah]
synonym: "protein targeting to nucleus" RELATED []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus
relationship: RO:0002339 GO:0005634 ! has target end location nucleus
creation_date: 2012-11-07T15:45:54Z

[Term]
id: GO:0034599
name: cellular response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk]
xref: Reactome:R-HSA-3299685 "Detoxification of Reactive Oxygen Species"
xref: Reactome:R-HSA-9707564 "Cytoprotection by HMOX1"
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0062197 ! cellular response to chemical stress

[Term]
id: GO:0034614
name: cellular response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]
synonym: "cellular response to active oxygen species" EXACT []
synonym: "cellular response to AOS" EXACT []
synonym: "cellular response to reactive oxidative species" EXACT []
synonym: "cellular response to reactive oxygen intermediate" EXACT []
synonym: "cellular response to ROI" EXACT []
synonym: "cellular response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:26523 ! has primary input reactive oxygen species

[Term]
id: GO:0034642
name: mitochondrion migration along actin filament
namespace: biological_process
def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220]
synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb]
synonym: "mitochondrial migration along microfilament" EXACT []
synonym: "mitochondrial migration, actin-mediated" EXACT []
synonym: "mitochondrion migration along microfilament" EXACT []
synonym: "mitochondrion transport along actin filament" EXACT []
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0051654 ! establishment of mitochondrion localization
is_a: GO:0099515 ! actin filament-based transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0034643
name: establishment of mitochondrion localization, microtubule-mediated
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]
synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah]
synonym: "microtubule-mediated mitochondrion localization" EXACT []
synonym: "mitochondrial localization, microtubule-mediated" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0051654 ! establishment of mitochondrion localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0034654
name: nucleobase-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:61120 ! has primary output nucleobase-containing molecular entity
relationship: RO:0004008 CHEBI:61120 ! has primary output nucleobase-containing molecular entity

[Term]
id: GO:0034655
name: nucleobase-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: goslim_chembl
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity
relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing molecular entity

[Term]
id: GO:0034762
name: regulation of transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of membrane transport" EXACT []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0055085 ! regulates transmembrane transport
relationship: RO:0002211 GO:0055085 ! regulates transmembrane transport

[Term]
id: GO:0034763
name: negative regulation of transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane transport" EXACT []
synonym: "down-regulation of transmembrane transport" EXACT []
synonym: "downregulation of transmembrane transport" EXACT []
synonym: "inhibition of transmembrane transport" NARROW []
synonym: "negative regulation of membrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport
relationship: RO:0002212 GO:0055085 ! negatively regulates transmembrane transport

[Term]
id: GO:0034764
name: positive regulation of transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane transport" NARROW []
synonym: "positive regulation of membrane transport" EXACT []
synonym: "stimulation of transmembrane transport" NARROW []
synonym: "up regulation of transmembrane transport" EXACT []
synonym: "up-regulation of transmembrane transport" EXACT []
synonym: "upregulation of transmembrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0055085 ! positively regulates transmembrane transport
relationship: RO:0002213 GO:0055085 ! positively regulates transmembrane transport

[Term]
id: GO:0034765
name: regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of ion membrane transport" EXACT []
synonym: "regulation of ion transmembrane transport" BROAD []
synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0043269 ! regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport
relationship: RO:0002211 GO:0034220 ! regulates monoatomic ion transmembrane transport

[Term]
id: GO:0034766
name: negative regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane ion transport" EXACT []
synonym: "down-regulation of transmembrane ion transport" EXACT []
synonym: "downregulation of transmembrane ion transport" EXACT []
synonym: "inhibition of transmembrane ion transport" NARROW []
synonym: "negative regulation of ion membrane transport" EXACT []
synonym: "negative regulation of ion transmembrane transport" BROAD []
synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport
relationship: RO:0002212 GO:0034220 ! negatively regulates monoatomic ion transmembrane transport

[Term]
id: GO:0034767
name: positive regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane ion transport" NARROW []
synonym: "positive regulation of ion membrane transport" EXACT []
synonym: "positive regulation of ion transmembrane transport" BROAD []
synonym: "positive regulation of transmembrane ion transport" EXACT []
synonym: "stimulation of transmembrane ion transport" NARROW []
synonym: "up regulation of transmembrane ion transport" EXACT []
synonym: "up-regulation of transmembrane ion transport" EXACT []
synonym: "upregulation of transmembrane ion transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport
relationship: RO:0002213 GO:0034220 ! positively regulates monoatomic ion transmembrane transport

[Term]
id: GO:0034769
name: basement membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.
synonym: "basal lamina disassembly" RELATED []
is_a: GO:0022617 ! extracellular matrix disassembly
is_a: GO:0071711 ! basement membrane organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005604 ! results in disassembly of basement membrane
relationship: RO:0002590 GO:0005604 ! results in disassembly of basement membrane
creation_date: 2009-08-13T11:27:24Z

[Term]
id: GO:0035050
name: embryonic heart tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004141 ! results in development of heart tube
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: BFO:0000050 GO:0048568 ! part of embryonic organ development
relationship: RO:0002296 UBERON:0004141 ! results in development of heart tube

[Term]
id: GO:0035051
name: cardiocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
synonym: "cardiac cell differentiation" EXACT []
synonym: "heart cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002315 CL:0002494 ! results in acquisition of features of cardiocyte

[Term]
id: GO:0035082
name: axoneme assembly
namespace: biological_process
def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "axoneme biogenesis" RELATED [GOC:mah]
synonym: "ciliary axoneme assembly" EXACT []
synonym: "cilium axoneme assembly" EXACT []
synonym: "cilium axoneme biogenesis" RELATED [GOC:mah]
synonym: "flagellar axoneme assembly" EXACT []
synonym: "flagellum axoneme assembly" EXACT []
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005930 ! results in assembly of axoneme
relationship: BFO:0000050 GO:0060271 ! part of cilium assembly
relationship: RO:0002588 GO:0005930 ! results in assembly of axoneme

[Term]
id: GO:0035107
name: appendage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage
relationship: BFO:0000050 GO:0048736 ! part of appendage development
relationship: RO:0002298 UBERON:0000026 ! results in morphogenesis of appendage

[Term]
id: GO:0035112
name: genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf]
synonym: "genital morphogenesis" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system
relationship: BFO:0000050 GO:0048806 ! part of genitalia development
relationship: RO:0002298 UBERON:0000990 ! results in morphogenesis of reproductive system

[Term]
id: GO:0035148
name: tube formation
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]
synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah]
synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000025 ! results in formation of tube
relationship: BFO:0000050 GO:0035239 ! part of tube morphogenesis
relationship: RO:0002297 UBERON:0000025 ! results in formation of tube

[Term]
id: GO:0035190
name: syncytial nuclear migration
namespace: biological_process
def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839]
is_a: GO:0007097 ! nuclear migration
intersection_of: GO:0007097 ! nuclear migration
intersection_of: BFO:0000066 CL:0000228 ! occurs in multinucleate cell
relationship: BFO:0000050 GO:0001700 ! part of embryonic development via the syncytial blastoderm
relationship: BFO:0000066 CL:0000228 ! occurs in multinucleate cell

[Term]
id: GO:0035234
name: ectopic germ cell programmed cell death
namespace: biological_process
def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
synonym: "programmed cell death of ectopic germ cells" EXACT []
synonym: "programmed cell death, ectopic germ cells" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! programmed cell death involved in cell development
intersection_of: GO:0012501 ! programmed cell death
intersection_of: BFO:0000066 CL:0000586 ! occurs in germ cell
relationship: BFO:0000066 CL:0000586 ! occurs in germ cell

[Term]
id: GO:0035239
name: tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube
relationship: BFO:0000050 GO:0035295 ! part of tube development
relationship: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube

[Term]
id: GO:0035240
name: dopamine binding
namespace: molecular_function
def: "Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732]
is_a: GO:0043169 ! cation binding
is_a: GO:1901338 ! catecholamine binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
relationship: RO:0004009 CHEBI:59905 ! has primary input

[Term]
id: GO:0035249
name: synaptic transmission, glutamatergic
namespace: biological_process
def: "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]
synonym: "glutamatergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0035260
name: internal genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [PMID:24793987, PMID:25247640]
is_a: GO:0035112 ! genitalia morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia
relationship: RO:0002298 UBERON:0004175 ! results in morphogenesis of internal genitalia

[Term]
id: GO:0035261
name: external genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [PMID:24793987, PMID:25247640]
is_a: GO:0035112 ! genitalia morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia
relationship: RO:0002298 UBERON:0004176 ! results in morphogenesis of external genitalia

[Term]
id: GO:0035262
name: gonad morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad
relationship: BFO:0000050 GO:0008406 ! part of gonad development
relationship: RO:0002298 UBERON:0000991 ! results in morphogenesis of gonad

[Term]
id: GO:0035264
name: multicellular organism growth
namespace: biological_process
def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
synonym: "body growth" RELATED []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism
relationship: RO:0002343 UBERON:0000468 ! results in growth of multicellular organism

[Term]
id: GO:0035265
name: organ growth
namespace: biological_process
def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0000062 ! results in growth of organ
relationship: RO:0002343 UBERON:0000062 ! results in growth of organ

[Term]
id: GO:0035270
name: endocrine system development
namespace: biological_process
def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000949 ! results in development of endocrine system
relationship: RO:0002296 UBERON:0000949 ! results in development of endocrine system

[Term]
id: GO:0035272
name: exocrine system development
namespace: biological_process
def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002330 ! results in development of exocrine system
relationship: RO:0002296 UBERON:0002330 ! results in development of exocrine system

[Term]
id: GO:0035282
name: segmentation
namespace: biological_process
def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
xref: Wikipedia:Segmentation_(biology)
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0035290
name: trunk segmentation
namespace: biological_process
def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
is_a: GO:0035282 ! segmentation
relationship: BFO:0000050 GO:0007350 ! part of blastoderm segmentation

[Term]
id: GO:0035295
name: tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000025 ! results in development of tube
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 UBERON:0000025 ! results in development of tube

[Term]
id: GO:0035372
name: protein localization to microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb]
synonym: "protein localisation to microtubule" EXACT [GOC:mah]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005874 ! has target end location microtubule
relationship: RO:0002339 GO:0005874 ! has target end location microtubule
creation_date: 2010-03-11T11:00:56Z

[Term]
id: GO:0035418
name: protein localization to synapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
synonym: "protein localisation to synapse" EXACT [GOC:mah]
is_a: GO:1902414 ! protein localization to cell junction
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0045202 ! has target end location synapse
relationship: RO:0002339 GO:0045202 ! has target end location synapse
creation_date: 2010-03-29T10:58:53Z

[Term]
id: GO:0035441
name: cell migration involved in vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0001570 ! part of vasculogenesis
relationship: BFO:0000050 GO:0001570 ! part of vasculogenesis
creation_date: 2010-04-09T03:53:01Z

[Term]
id: GO:0035556
name: intracellular signal transduction
namespace: biological_process
alt_id: GO:0007242
alt_id: GO:0007243
alt_id: GO:0023013
alt_id: GO:0023034
def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
subset: goslim_drosophila
synonym: "intracellular signal transduction pathway" NARROW []
synonym: "intracellular signaling cascade" RELATED [GOC:signaling]
synonym: "intracellular signaling pathway" RELATED []
synonym: "signal transmission via intracellular cascade" NARROW []
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
created_by: bf
creation_date: 2010-05-14T01:14:37Z

[Term]
id: GO:0035562
name: negative regulation of chromatin binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0051100 ! negative regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003682 ! negatively regulates chromatin binding
relationship: RO:0002212 GO:0003682 ! negatively regulates chromatin binding
creation_date: 2010-05-19T10:29:06Z

[Term]
id: GO:0035563
name: positive regulation of chromatin binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130]
subset: gocheck_do_not_annotate
is_a: GO:0051099 ! positive regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003682 ! positively regulates chromatin binding
relationship: RO:0002213 GO:0003682 ! positively regulates chromatin binding
creation_date: 2010-05-19T10:29:41Z

[Term]
id: GO:0035577
name: azurophil granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095]
synonym: "primary granule membrane" EXACT []
is_a: GO:0005765 ! lysosomal membrane
is_a: GO:0030667 ! secretory granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0042582 ! bounding layer of azurophil granule
relationship: RO:0002007 GO:0042582 ! bounding layer of azurophil granule
creation_date: 2010-10-05T01:29:10Z

[Term]
id: GO:0035592
name: establishment of protein localization to extracellular region
namespace: biological_process
def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF]
synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "establishment of protein localization in extracellular region" EXACT []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071692 ! protein localization to extracellular region
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
created_by: bf
creation_date: 2010-11-09T10:25:08Z

[Term]
id: GO:0035694
name: mitochondrial protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228]
synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf]
synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf]
xref: Reactome:R-HSA-9837999 "Mitochondrial protein degradation"
is_a: GO:0030163 ! protein catabolic process
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0007005 ! part of mitochondrion organization
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
creation_date: 2011-02-28T11:06:40Z

[Term]
id: GO:0035700
name: astrocyte chemotaxis
namespace: biological_process
def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471]
is_a: GO:0043615 ! astrocyte cell migration
is_a: GO:0060326 ! cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000127 ! results in movement of astrocyte
creation_date: 2011-02-28T03:17:52Z

[Term]
id: GO:0035701
name: hematopoietic stem cell migration
namespace: biological_process
def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092]
synonym: "hemopoietic stem cell migration" EXACT [CL:0000037]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000037 ! results in movement of hematopoietic stem cell
relationship: RO:0002565 CL:0000037 ! results in movement of hematopoietic stem cell
creation_date: 2011-02-28T03:20:36Z

[Term]
id: GO:0035702
name: monocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716]
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000576 ! acts on population of monocyte
relationship: RO:0012003 CL:0000576 ! acts on population of monocyte
creation_date: 2011-03-02T11:32:57Z

[Term]
id: GO:0035719
name: tRNA import into nucleus
namespace: biological_process
def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305]
synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305]
synonym: "tRNA nuclear import" EXACT [GOC:vw]
is_a: GO:0006404 ! RNA import into nucleus
is_a: GO:0051031 ! tRNA transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
intersection_of: RO:0004009 CHEBI:17843 ! has primary input
creation_date: 2011-03-03T04:32:35Z

[Term]
id: GO:0035735
name: intraciliary transport involved in cilium assembly
namespace: biological_process
def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia]
synonym: "intraciliary transport involved in cilium morphogenesis" RELATED []
synonym: "intraflagellar transport" BROAD []
synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED []
xref: Reactome:R-HSA-5620924 "Intraflagellar transport"
is_a: GO:0042073 ! intraciliary transport
intersection_of: GO:0042073 ! intraciliary transport
intersection_of: BFO:0000050 GO:0060271 ! part of cilium assembly
relationship: BFO:0000050 GO:0060271 ! part of cilium assembly
creation_date: 2011-03-17T10:55:42Z

[Term]
id: GO:0035736
name: cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis
relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis
creation_date: 2011-03-17T10:57:03Z

[Term]
id: GO:0035767
name: endothelial cell chemotaxis
namespace: biological_process
def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF]
is_a: GO:0043542 ! endothelial cell migration
is_a: GO:0060326 ! cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell
creation_date: 2011-03-31T04:31:37Z

[Term]
id: GO:0035779
name: angioblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf]
synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566]
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell
relationship: BFO:0000050 GO:0001568 ! part of blood vessel development
relationship: RO:0002315 CL:0000566 ! results in acquisition of features of angioblastic mesenchymal cell
creation_date: 2011-04-04T11:10:38Z

[Term]
id: GO:0035855
name: megakaryocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk]
synonym: "megakaryocyte cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 CL:0000556 ! results in development of megakaryocyte
relationship: BFO:0000050 GO:0030219 ! part of megakaryocyte differentiation
relationship: RO:0002296 CL:0000556 ! results in development of megakaryocyte
creation_date: 2011-05-13T01:28:06Z

[Term]
id: GO:0035869
name: ciliary transition zone
namespace: cellular_component
def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]
comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone.
synonym: "cilial transition zone" EXACT []
synonym: "cilium transition zone" EXACT []
synonym: "connecting cilium" RELATED []
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005929 ! part of cilium
creation_date: 2011-05-25T03:09:58Z

[Term]
id: GO:0035886
name: vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]
synonym: "vascular smooth muscle cell differentiation" EXACT []
synonym: "VSMC differentiation" EXACT [PMID:16151017]
is_a: GO:0051145 ! smooth muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell
relationship: BFO:0000050 GO:0001944 ! part of vasculature development
relationship: RO:0002315 CL:0000359 ! results in acquisition of features of vascular associated smooth muscle cell
creation_date: 2011-06-08T11:23:52Z

[Term]
id: GO:0035887
name: aortic smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl]
is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell
relationship: RO:0002315 CL:0002539 ! results in acquisition of features of aortic smooth muscle cell
creation_date: 2011-06-08T11:34:26Z

[Term]
id: GO:0035904
name: aorta development
namespace: biological_process
def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0060840 ! artery development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000947 ! results in development of aorta
relationship: RO:0002296 UBERON:0000947 ! results in development of aorta
creation_date: 2011-06-24T11:00:07Z

[Term]
id: GO:0035905
name: ascending aorta development
namespace: biological_process
def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001496 ! results in development of ascending aorta
relationship: BFO:0000050 GO:0035904 ! part of aorta development
relationship: RO:0002296 UBERON:0001496 ! results in development of ascending aorta
creation_date: 2011-06-24T11:02:01Z

[Term]
id: GO:0035906
name: descending aorta development
namespace: biological_process
def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001514 ! results in development of descending aorta
relationship: BFO:0000050 GO:0035904 ! part of aorta development
relationship: RO:0002296 UBERON:0001514 ! results in development of descending aorta
creation_date: 2011-06-24T11:05:22Z

[Term]
id: GO:0035907
name: dorsal aorta development
namespace: biological_process
def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035904 ! aorta development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta
relationship: RO:0002296 UBERON:0005805 ! results in development of dorsal aorta
creation_date: 2011-06-24T11:07:01Z

[Term]
id: GO:0035909
name: aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta
relationship: BFO:0000050 GO:0035904 ! part of aorta development
relationship: RO:0002298 UBERON:0000947 ! results in morphogenesis of aorta
creation_date: 2011-06-24T11:11:11Z

[Term]
id: GO:0035910
name: ascending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta
relationship: BFO:0000050 GO:0035905 ! part of ascending aorta development
relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis
relationship: RO:0002298 UBERON:0001496 ! results in morphogenesis of ascending aorta
creation_date: 2011-06-24T11:14:52Z

[Term]
id: GO:0035911
name: descending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta
relationship: BFO:0000050 GO:0035906 ! part of descending aorta development
relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis
relationship: RO:0002298 UBERON:0001514 ! results in morphogenesis of descending aorta
creation_date: 2011-06-24T11:19:24Z

[Term]
id: GO:0035912
name: dorsal aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035909 ! aorta morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta
relationship: BFO:0000050 GO:0035907 ! part of dorsal aorta development
relationship: RO:0002298 UBERON:0005805 ! results in morphogenesis of dorsal aorta
creation_date: 2011-06-24T11:22:14Z

[Term]
id: GO:0035914
name: skeletal muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle
relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development
relationship: RO:0002315 CL:0000188 ! results in acquisition of features of cell of skeletal muscle
creation_date: 2011-06-24T02:36:19Z

[Term]
id: GO:0035927
name: RNA import into mitochondrion
namespace: biological_process
def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904]
synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans]
synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf]
is_a: GO:0050658 ! RNA transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
creation_date: 2011-07-19T09:39:37Z

[Term]
id: GO:0035929
name: steroid hormone secretion
namespace: biological_process
def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl]
is_a: GO:0060986 ! endocrine hormone secretion
is_a: GO:0140353 ! lipid export from cell
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:26764 ! has primary input
relationship: RO:0004009 CHEBI:26764 ! has primary input
creation_date: 2011-07-20T01:01:00Z

[Term]
id: GO:0035935
name: androgen secretion
namespace: biological_process
def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl]
is_a: GO:0035929 ! steroid hormone secretion
creation_date: 2011-07-20T01:11:31Z

[Term]
id: GO:0035981
name: tongue muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851]
is_a: GO:0098528 ! skeletal muscle fiber differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002673 ! results in acquisition of features of tongue muscle cell
relationship: RO:0002315 CL:0002673 ! results in acquisition of features of tongue muscle cell
creation_date: 2011-08-22T01:35:16Z

[Term]
id: GO:0035987
name: endodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332]
synonym: "endoderm cell differentiation" EXACT [CL:0000223]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell
relationship: BFO:0000050 GO:0001706 ! part of endoderm formation
relationship: RO:0002315 CL:0000223 ! results in acquisition of features of endodermal cell
creation_date: 2011-08-25T04:50:36Z

[Term]
id: GO:0035989
name: tendon development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043]
synonym: "sinew development" RELATED [UBERON:0000043]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000043 ! results in development of tendon
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002296 UBERON:0000043 ! results in development of tendon
creation_date: 2011-08-26T04:14:30Z

[Term]
id: GO:0035990
name: tendon cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429]
synonym: "muscle attachment cell differentiation" EXACT [CL:0000388]
synonym: "tenocyte differentiation" RELATED [CL:0000388]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000388 ! results in acquisition of features of tendon cell
relationship: BFO:0000050 GO:0035992 ! part of tendon formation
relationship: RO:0002315 CL:0000388 ! results in acquisition of features of tendon cell
creation_date: 2011-08-26T04:16:06Z

[Term]
id: GO:0035992
name: tendon formation
namespace: biological_process
def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000043 ! results in formation of tendon
relationship: BFO:0000050 GO:0035989 ! part of tendon development
relationship: RO:0002297 UBERON:0000043 ! results in formation of tendon
creation_date: 2011-08-30T01:35:10Z

[Term]
id: GO:0036035
name: osteoclast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf]
synonym: "osteoclast cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
is_a: GO:0098751 ! bone cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0000092 ! results in development of osteoclast
relationship: BFO:0000050 GO:0030316 ! part of osteoclast differentiation
relationship: RO:0002296 CL:0000092 ! results in development of osteoclast
creation_date: 2011-11-02T05:20:35Z

[Term]
id: GO:0036072
name: direct ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034]
is_a: GO:0001503 ! ossification
creation_date: 2011-12-19T01:47:22Z

[Term]
id: GO:0036093
name: germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000586 ! acts on population of germ cell
relationship: BFO:0000050 GO:0007276 ! part of gamete generation
relationship: RO:0012003 CL:0000586 ! acts on population of germ cell
creation_date: 2012-01-17T04:06:27Z

[Term]
id: GO:0036094
name: small molecule binding
namespace: molecular_function
def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_agr
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
is_a: GO:0005488 ! binding
created_by: bf
creation_date: 2012-01-17T04:20:34Z

[Term]
id: GO:0036135
name: Schwann cell migration
namespace: biological_process
def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintenance and function." [CL:0002573, PMID:20335460]
is_a: GO:0008347 ! glial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0002573 ! results in movement of Schwann cell
relationship: RO:0002565 CL:0002573 ! results in movement of Schwann cell
creation_date: 2012-03-06T10:44:39Z

[Term]
id: GO:0036145
name: dendritic cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316]
synonym: "DC homeostasis" RELATED [PMID:19176316]
is_a: GO:0001776 ! leukocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000451 ! acts on population of dendritic cell
relationship: RO:0012003 CL:0000451 ! acts on population of dendritic cell
creation_date: 2012-03-12T11:05:36Z

[Term]
id: GO:0036160
name: melanocyte-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone]
synonym: "MSH secretion" EXACT [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion
creation_date: 2012-03-26T01:16:55Z

[Term]
id: GO:0036179
name: osteoclast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg]
synonym: "chondroclast maturation" RELATED [CL:0000092]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000092 ! results in maturation of osteoclast
relationship: BFO:0000050 GO:0036035 ! part of osteoclast development
relationship: RO:0002299 CL:0000092 ! results in maturation of osteoclast
creation_date: 2012-03-29T02:04:00Z

[Term]
id: GO:0036194
name: muscle cell projection
namespace: cellular_component
def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
synonym: "muscle arm" NARROW [GOC:kmv]
synonym: "myocyte projection" EXACT [CL:0000187]
synonym: "myopodia" NARROW [GOC:kmv]
is_a: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell
relationship: BFO:0000050 CL:0000187 ! part of muscle cell
creation_date: 2012-04-20T10:20:47Z

[Term]
id: GO:0036195
name: muscle cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
is_a: GO:0031253 ! cell projection membrane
intersection_of: GO:0031253 ! cell projection membrane
intersection_of: BFO:0000050 GO:0036194 ! part of muscle cell projection
relationship: BFO:0000050 GO:0036194 ! part of muscle cell projection
creation_date: 2012-04-20T10:21:51Z

[Term]
id: GO:0036211
name: protein modification process
namespace: biological_process
alt_id: GO:0006464
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
synonym: "cellular protein modification process" EXACT []
synonym: "process resulting in protein modification" EXACT []
synonym: "protein modification" EXACT [GOC:bf]
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0043412 ! macromolecule modification
created_by: bf
creation_date: 2012-04-26T01:47:12Z

[Term]
id: GO:0036230
name: granulocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn]
is_a: GO:0002274 ! myeloid leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000094 ! has primary input granulocyte
relationship: RO:0004009 CL:0000094 ! has primary input granulocyte
creation_date: 2012-05-11T10:57:48Z

[Term]
id: GO:0036293
name: response to decreased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]
comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'.
synonym: "response to lowered oxygen levels" EXACT [GOC:bf]
is_a: GO:0070482 ! response to oxygen levels
creation_date: 2012-07-20T01:05:46Z

[Term]
id: GO:0036334
name: epidermal stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529]
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis
relationship: RO:0012003 CL:1000428 ! acts on population of stem cell of epidermis
creation_date: 2012-09-05T10:21:23Z

[Term]
id: GO:0036336
name: dendritic cell migration
namespace: biological_process
def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990]
is_a: GO:0071674 ! mononuclear cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell
relationship: RO:0002565 CL:0000451 ! results in movement of dendritic cell
creation_date: 2012-09-05T10:24:46Z

[Term]
id: GO:0036477
name: somatodendritic compartment
namespace: cellular_component
def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000540 ! part of neuron
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
creation_date: 2014-07-24T10:06:19Z

[Term]
id: GO:0036484
name: trunk neural crest cell migration
namespace: biological_process
def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]
synonym: "trunk NCC migration" EXACT [PMID:2387238]
is_a: GO:0001755 ! neural crest cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000011 ! results in movement of migratory trunk neural crest cell
relationship: BFO:0000050 GO:0035290 ! part of trunk segmentation
relationship: RO:0002565 CL:0000011 ! results in movement of migratory trunk neural crest cell
creation_date: 2014-08-26T15:27:44Z

[Term]
id: GO:0036504
name: Golgi membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691]
synonym: "Golgi apparatus membrane fusion" EXACT []
synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf]
synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609]
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane
relationship: BFO:0000050 GO:0090168 ! part of Golgi reassembly
relationship: RO:0012008 GO:0000139 ! results in fusion of Golgi membrane
creation_date: 2015-05-21T10:05:06Z

[Term]
id: GO:0036520
name: astrocyte-dopaminergic neuron signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258]
synonym: "astrocyte-dopaminergic neuron cell signaling" EXACT [GOC:bf]
synonym: "dopaminergic neuron-astrocyte crosstalk" RELATED [PMID:21752258]
synonym: "mesencephalic dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258]
synonym: "midbrain dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258]
is_a: GO:0150098 ! glial cell-neuron signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000127 ! has start location astrocyte
intersection_of: RO:0002232 CL:0000700 ! has end location dopaminergic neuron
relationship: RO:0002231 CL:0000127 ! has start location astrocyte
relationship: RO:0002232 CL:0000700 ! has end location dopaminergic neuron
creation_date: 2016-02-29T14:05:47Z

[Term]
id: GO:0038023
name: signaling receptor activity
namespace: molecular_function
def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "receptor activity" BROAD []
synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf]
synonym: "signalling receptor activity" EXACT []
is_a: GO:0060089 ! molecular transducer activity
creation_date: 2011-08-01T02:45:27Z

[Term]
id: GO:0038161
name: prolactin signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429]
synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246]
synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0019221 ! cytokine-mediated signaling pathway
creation_date: 2012-05-14T01:52:59Z

[Term]
id: GO:0038187
name: pattern recognition receptor activity
namespace: molecular_function
def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response." [GOC:ar, GOC:bf]
synonym: "macrophage receptor activity" RELATED []
synonym: "MAMP receptor activity" NARROW []
synonym: "microbe-associated molecular pattern receptor activity" NARROW []
synonym: "PAMP receptor activity" NARROW []
synonym: "pathogen associated molecular pattern receptor activity" NARROW []
synonym: "PRR" EXACT []
synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor]
synonym: "signaling pattern recognition receptor activity" RELATED []
xref: Wikipedia:Pattern_recognition_receptor
is_a: GO:0038023 ! signaling receptor activity
creation_date: 2013-05-29T15:24:44Z

[Term]
id: GO:0040007
name: growth
namespace: biological_process
alt_id: GO:0048590
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
synonym: "growth pattern" RELATED []
synonym: "non-developmental growth" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0044848 ! biological phase
relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms

[Term]
id: GO:0040008
name: regulation of growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0040007 ! regulates growth
relationship: RO:0002211 GO:0040007 ! regulates growth

[Term]
id: GO:0040011
name: locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040012
name: regulation of locomotion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0040011 ! regulates locomotion
relationship: RO:0002211 GO:0040011 ! regulates locomotion

[Term]
id: GO:0040013
name: negative regulation of locomotion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "down regulation of locomotion" EXACT []
synonym: "down-regulation of locomotion" EXACT []
synonym: "downregulation of locomotion" EXACT []
synonym: "inhibition of locomotion" NARROW []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0040011 ! negatively regulates locomotion
relationship: RO:0002212 GO:0040011 ! negatively regulates locomotion

[Term]
id: GO:0040014
name: regulation of multicellular organism growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035264 ! regulates multicellular organism growth
relationship: RO:0002211 GO:0035264 ! regulates multicellular organism growth

[Term]
id: GO:0040015
name: negative regulation of multicellular organism growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth
relationship: RO:0002212 GO:0035264 ! negatively regulates multicellular organism growth

[Term]
id: GO:0040016
name: embryonic cleavage
namespace: biological_process
def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
is_a: GO:0051301 ! cell division
relationship: BFO:0000050 GO:0009790 ! part of embryo development

[Term]
id: GO:0040017
name: positive regulation of locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "activation of locomotion" NARROW []
synonym: "stimulation of locomotion" NARROW []
synonym: "up regulation of locomotion" EXACT []
synonym: "up-regulation of locomotion" EXACT []
synonym: "upregulation of locomotion" EXACT []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0040011 ! positively regulates locomotion
relationship: RO:0002213 GO:0040011 ! positively regulates locomotion

[Term]
id: GO:0040018
name: positive regulation of multicellular organism growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth
relationship: RO:0002213 GO:0035264 ! positively regulates multicellular organism growth

[Term]
id: GO:0040019
name: positive regulation of embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "activation of embryonic development" NARROW []
synonym: "stimulation of embryonic development" NARROW []
synonym: "up regulation of embryonic development" EXACT []
synonym: "up-regulation of embryonic development" EXACT []
synonym: "upregulation of embryonic development" EXACT []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009790 ! positively regulates embryo development
relationship: RO:0002213 GO:0009790 ! positively regulates embryo development

[Term]
id: GO:0040020
name: regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
synonym: "regulation of meiosis" BROAD [GOC:vw]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0140013 ! regulates meiotic nuclear division
relationship: RO:0002211 GO:0140013 ! regulates meiotic nuclear division

[Term]
id: GO:0040029
name: epigenetic regulation of gene expression
namespace: biological_process
def: "A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]
subset: goslim_plant
synonym: "regulation of gene expression, epigenetic" EXACT []
xref: Reactome:R-HSA-212165 "Epigenetic regulation of gene expression"
xref: Reactome:R-HSA-8986944 "Transcriptional Regulation by MECP2"
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0040034
name: regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
synonym: "developmental timing" RELATED []
synonym: "heterochronic regulation of development" EXACT []
synonym: "temporal regulation of development" EXACT []
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0042053
name: regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "regulation of dopamine metabolism" EXACT []
is_a: GO:0042069 ! regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042417 ! regulates dopamine metabolic process
relationship: RO:0002211 GO:0042417 ! regulates dopamine metabolic process

[Term]
id: GO:0042063
name: gliogenesis
namespace: biological_process
def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]
is_a: GO:0022008 ! neurogenesis
intersection_of: GO:0008150 ! biological_process
intersection_of: RO:0002297 CL:0000125 ! results in formation of glial cell
relationship: RO:0002297 CL:0000125 ! results in formation of glial cell

[Term]
id: GO:0042065
name: glial cell growth
namespace: biological_process
def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0040007 ! growth
intersection_of: RO:0002343 CL:0000125 ! results in growth of glial cell
relationship: BFO:0000050 GO:0042063 ! part of gliogenesis
relationship: RO:0002343 CL:0000125 ! results in growth of glial cell

[Term]
id: GO:0042069
name: regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators]
synonym: "regulation of catecholamine metabolism" EXACT []
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process
relationship: RO:0002211 GO:0006584 ! regulates catecholamine metabolic process

[Term]
id: GO:0042073
name: intraciliary transport
namespace: biological_process
def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "IFT" RELATED []
synonym: "intraflagellar transport" EXACT []
synonym: "intraflagellar transport involved in cilium organization" EXACT []
synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT []
xref: Wikipedia:Intraflagellar_transport
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0031503 ! protein-containing complex localization
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0005929 ! occurs in cilium
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex
relationship: BFO:0000050 GO:0044782 ! part of cilium organization
relationship: BFO:0000066 GO:0005929 ! occurs in cilium

[Term]
id: GO:0042074
name: cell migration involved in gastrulation
namespace: biological_process
def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, PMID:16099638]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation
relationship: BFO:0000050 GO:0007369 ! part of gastrulation

[Term]
id: GO:0042078
name: germ-line stem cell division
namespace: biological_process
def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
synonym: "germ-line stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell
relationship: BFO:0000050 GO:0007281 ! part of germ cell development
relationship: RO:0004009 CL:0000014 ! has primary input germ line stem cell

[Term]
id: GO:0042098
name: T cell proliferation
namespace: biological_process
def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl]
synonym: "T lymphocyte proliferation" EXACT []
synonym: "T-cell proliferation" EXACT []
synonym: "T-lymphocyte proliferation" EXACT []
is_a: GO:0042110 ! T cell activation
is_a: GO:0046651 ! lymphocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell
relationship: RO:0012003 CL:0000084 ! acts on population of T cell

[Term]
id: GO:0042102
name: positive regulation of T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai]
synonym: "activation of T cell proliferation" NARROW []
synonym: "positive regulation of T lymphocyte proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte proliferation" EXACT []
synonym: "stimulation of T cell proliferation" NARROW []
synonym: "up regulation of T cell proliferation" EXACT []
synonym: "up-regulation of T cell proliferation" EXACT []
synonym: "upregulation of T cell proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042098 ! positively regulates T cell proliferation
relationship: RO:0002213 GO:0042098 ! positively regulates T cell proliferation

[Term]
id: GO:0042103
name: positive regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl]
synonym: "activation of T cell homeostatic proliferation" NARROW []
synonym: "positive regulation of resting T cell proliferation" EXACT []
synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "positive regulation of T-cell homeostatic proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT []
synonym: "stimulation of T cell homeostatic proliferation" NARROW []
synonym: "up regulation of T cell homeostatic proliferation" EXACT []
synonym: "up-regulation of T cell homeostatic proliferation" EXACT []
synonym: "upregulation of T cell homeostatic proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001777 ! positively regulates T cell homeostatic proliferation
relationship: RO:0002213 GO:0001777 ! positively regulates T cell homeostatic proliferation

[Term]
id: GO:0042110
name: T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149]
synonym: "T lymphocyte activation" EXACT []
synonym: "T-cell activation" EXACT []
synonym: "T-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000084 ! has primary input T cell
relationship: RO:0004009 CL:0000084 ! has primary input T cell

[Term]
id: GO:0042116
name: macrophage activation
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]
synonym: "macrophage polarization" EXACT []
is_a: GO:0002274 ! myeloid leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000235 ! has primary input macrophage
relationship: RO:0004009 CL:0000235 ! has primary input macrophage

[Term]
id: GO:0042117
name: monocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000576 ! has primary input monocyte
relationship: RO:0004009 CL:0000576 ! has primary input monocyte

[Term]
id: GO:0042118
name: endothelial cell activation
namespace: biological_process
def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000115 ! has primary input endothelial cell
relationship: RO:0004009 CL:0000115 ! has primary input endothelial cell

[Term]
id: GO:0042127
name: regulation of cell population proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
synonym: "regulation of cell proliferation" RELATED []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008283 ! regulates cell population proliferation
relationship: RO:0002211 GO:0008283 ! regulates cell population proliferation

[Term]
id: GO:0042129
name: regulation of T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl]
synonym: "regulation of T lymphocyte proliferation" EXACT []
synonym: "regulation of T-cell proliferation" EXACT []
synonym: "regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042098 ! regulates T cell proliferation
relationship: RO:0002211 GO:0042098 ! regulates T cell proliferation

[Term]
id: GO:0042130
name: negative regulation of T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl]
synonym: "down regulation of T cell proliferation" EXACT []
synonym: "down-regulation of T cell proliferation" EXACT []
synonym: "downregulation of T cell proliferation" EXACT []
synonym: "inhibition of T cell proliferation" NARROW []
synonym: "negative regulation of T lymphocyte proliferation" EXACT []
synonym: "negative regulation of T-cell proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042098 ! negatively regulates T cell proliferation
relationship: RO:0002212 GO:0042098 ! negatively regulates T cell proliferation

[Term]
id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def: "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0043169 ! cation binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: RO:0004009 CHEBI:15355 ! has primary input

[Term]
id: GO:0042170
name: plastid membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0009536 ! part of plastid
relationship: BFO:0000050 GO:0009526 ! part of plastid envelope

[Term]
id: GO:0042173
name: regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl]
is_a: GO:0043937 ! regulation of sporulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030435 ! regulates sporulation resulting in formation of a cellular spore
relationship: RO:0002211 GO:0030435 ! regulates sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042175
name: nuclear outer membrane-endoplasmic reticulum membrane network
namespace: cellular_component
def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
synonym: "NE-ER continuum" RELATED []
synonym: "NE-ER network" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah]
synonym: "nuclear envelope-ER network" RELATED []
synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah]
synonym: "nuclear membrane-ER network" EXACT [GOC:mah]
is_a: GO:0016020 ! membrane
relationship: BFO:0000050 GO:0012505 ! part of endomembrane system

[Term]
id: GO:0042176
name: regulation of protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]
synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolic process" EXACT []
synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of cyclin breakdown" NARROW [GOC:obol]
synonym: "regulation of cyclin catabolic process" NARROW []
synonym: "regulation of cyclin catabolism" NARROW [GOC:obol]
synonym: "regulation of cyclin degradation" NARROW [GOC:obol]
synonym: "regulation of degradation of cyclin" NARROW [GOC:obol]
synonym: "regulation of protein breakdown" EXACT []
synonym: "regulation of protein catabolism" EXACT []
synonym: "regulation of protein degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030163 ! regulates protein catabolic process
relationship: RO:0002211 GO:0030163 ! regulates protein catabolic process
creation_date: 2014-08-21T15:05:45Z

[Term]
id: GO:0042177
name: negative regulation of protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]
synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein catabolic process" EXACT []
synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process" EXACT []
synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein catabolic process" EXACT []
synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein catabolic process" NARROW []
synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolic process" EXACT []
synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein breakdown" EXACT []
synonym: "negative regulation of protein catabolism" EXACT []
synonym: "negative regulation of protein degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process
relationship: RO:0002212 GO:0030163 ! negatively regulates protein catabolic process

[Term]
id: GO:0042180
name: ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]
subset: goslim_pir
synonym: "ketone metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042181
name: ketone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
synonym: "ketone anabolism" EXACT []
synonym: "ketone biosynthesis" EXACT []
synonym: "ketone formation" EXACT []
synonym: "ketone synthesis" EXACT []
is_a: GO:0042180 ! ketone metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0042221
name: response to chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_plant_ribbon
subset: goslim_yeast
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:24431 ! has primary input chemical entity
relationship: RO:0004009 CHEBI:24431 ! has primary input chemical entity

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "ribosome biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0042255
name: ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]
subset: goslim_yeast
synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw]
is_a: GO:0140694 ! membraneless organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005840 ! results in assembly of ribosome
relationship: BFO:0000050 GO:0042254 ! part of ribosome biogenesis
relationship: RO:0002588 GO:0005840 ! results in assembly of ribosome

[Term]
id: GO:0042268
name: regulation of cytolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, GOC:mtg_apoptosis]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019835 ! regulates cytolysis
relationship: RO:0002211 GO:0019835 ! regulates cytolysis

[Term]
id: GO:0042277
name: peptide binding
namespace: molecular_function
def: "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion

[Term]
id: GO:0042306
name: regulation of protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]
synonym: "regulation of protein import into cell nucleus" EXACT []
synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of protein-nucleus import" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
is_a: GO:1900180 ! regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006606 ! regulates protein import into nucleus
relationship: RO:0002211 GO:0006606 ! regulates protein import into nucleus

[Term]
id: GO:0042307
name: positive regulation of protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "activation of protein import into nucleus" NARROW []
synonym: "positive regulation of protein import into cell nucleus" EXACT []
synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of protein-nucleus import" EXACT []
synonym: "stimulation of protein import into nucleus" NARROW []
synonym: "up regulation of protein import into nucleus" EXACT []
synonym: "up-regulation of protein import into nucleus" EXACT []
synonym: "upregulation of protein import into nucleus" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006606 ! positively regulates protein import into nucleus
relationship: RO:0002213 GO:0006606 ! positively regulates protein import into nucleus

[Term]
id: GO:0042308
name: negative regulation of protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "down regulation of protein import into nucleus" EXACT []
synonym: "down-regulation of protein import into nucleus" EXACT []
synonym: "downregulation of protein import into nucleus" EXACT []
synonym: "inhibition of protein import into nucleus" NARROW []
synonym: "negative regulation of protein import into cell nucleus" EXACT []
synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of protein-nucleus import" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006606 ! negatively regulates protein import into nucleus
relationship: RO:0002212 GO:0006606 ! negatively regulates protein import into nucleus

[Term]
id: GO:0042325
name: regulation of phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_obsoletion_candidate
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016310 ! regulates phosphorylation
relationship: RO:0002211 GO:0016310 ! regulates phosphorylation

[Term]
id: GO:0042326
name: negative regulation of phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_obsoletion_candidate
synonym: "down regulation of phosphorylation" EXACT []
synonym: "down-regulation of phosphorylation" EXACT []
synonym: "downregulation of phosphorylation" EXACT []
synonym: "inhibition of phosphorylation" NARROW []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016310 ! negatively regulates phosphorylation
relationship: RO:0002212 GO:0016310 ! negatively regulates phosphorylation

[Term]
id: GO:0042327
name: positive regulation of phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
synonym: "activation of phosphorylation" NARROW []
synonym: "stimulation of phosphorylation" NARROW []
synonym: "up regulation of phosphorylation" EXACT []
synonym: "up-regulation of phosphorylation" EXACT []
synonym: "upregulation of phosphorylation" EXACT []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016310 ! positively regulates phosphorylation
relationship: RO:0002213 GO:0016310 ! positively regulates phosphorylation

[Term]
id: GO:0042330
name: taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023]
synonym: "directed movement in response to stimulus" EXACT []
xref: Wikipedia:Taxis
is_a: GO:0040011 ! locomotion
relationship: BFO:0000050 GO:0009605 ! part of response to external stimulus

[Term]
id: GO:0042379
name: chemokine receptor binding
namespace: molecular_function
def: "Binding to a chemokine receptor." [GOC:ai]
synonym: "chemokine receptor ligand" NARROW []
is_a: GO:0001664 ! G protein-coupled receptor binding
is_a: GO:0005126 ! cytokine receptor binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000001128 ! has primary input chemokine receptor
relationship: RO:0004009 PR:000001128 ! has primary input chemokine receptor

[Term]
id: GO:0042391
name: regulation of membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
is_a: GO:0065008 ! regulation of biological quality
relationship: BFO:0000051 GO:0034220 ! has part monoatomic ion transmembrane transport

[Term]
id: GO:0042401
name: biogenic amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
synonym: "biogenic amine anabolism" EXACT []
synonym: "biogenic amine biosynthesis" EXACT []
synonym: "biogenic amine formation" EXACT []
synonym: "biogenic amine synthesis" EXACT []
synonym: "cellular biogenic amine biosynthetic process" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0009309 ! amine biosynthetic process

[Term]
id: GO:0042402
name: biogenic amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732]
synonym: "biogenic amine breakdown" EXACT []
synonym: "biogenic amine catabolism" EXACT []
synonym: "biogenic amine degradation" EXACT []
is_a: GO:0009310 ! amine catabolic process

[Term]
id: GO:0042415
name: norepinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol metabolic process" EXACT []
synonym: "levarterenol metabolism" EXACT []
synonym: "noradrenaline metabolic process" EXACT []
synonym: "noradrenaline metabolism" EXACT []
synonym: "norepinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:72587 ! has primary input or output
relationship: RO:0004007 CHEBI:72587 ! has primary input or output

[Term]
id: GO:0042416
name: dopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine anabolism" EXACT []
synonym: "dopamine biosynthesis" EXACT []
synonym: "dopamine formation" EXACT []
synonym: "dopamine synthesis" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:59905 ! has primary output
relationship: RO:0004008 CHEBI:59905 ! has primary output

[Term]
id: GO:0042417
name: dopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:59905 ! has primary input or output
relationship: RO:0004007 CHEBI:59905 ! has primary input or output

[Term]
id: GO:0042420
name: dopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine breakdown" EXACT []
synonym: "dopamine catabolism" EXACT []
synonym: "dopamine degradation" EXACT []
xref: Reactome:R-HSA-379397 "Enzymatic degradation of dopamine by COMT"
xref: Reactome:R-HSA-379398 "Enzymatic degradation of Dopamine by monoamine oxidase"
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
relationship: RO:0004009 CHEBI:59905 ! has primary input

[Term]
id: GO:0042421
name: norepinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol biosynthesis" EXACT []
synonym: "levarterenol biosynthetic process" EXACT []
synonym: "noradrenaline biosynthesis" EXACT []
synonym: "noradrenaline biosynthetic process" EXACT []
synonym: "norepinephrine anabolism" EXACT []
synonym: "norepinephrine biosynthesis" EXACT []
synonym: "norepinephrine formation" EXACT []
synonym: "norepinephrine synthesis" EXACT []
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:72587 ! has primary output
relationship: RO:0004008 CHEBI:72587 ! has primary output

[Term]
id: GO:0042422
name: norepinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol catabolic process" EXACT []
synonym: "levarterenol catabolism" EXACT []
synonym: "noradrenaline catabolic process" EXACT []
synonym: "noradrenaline catabolism" EXACT []
synonym: "norepinephrine breakdown" EXACT []
synonym: "norepinephrine catabolism" EXACT []
synonym: "norepinephrine degradation" EXACT []
xref: Wikipedia:Norepinephrine#Degradation
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:72587 ! has primary input
relationship: RO:0004009 CHEBI:72587 ! has primary input

[Term]
id: GO:0042423
name: catecholamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine anabolism" EXACT []
synonym: "catecholamine biosynthesis" EXACT []
synonym: "catecholamine formation" EXACT []
synonym: "catecholamine synthesis" EXACT []
xref: Reactome:R-HSA-209905 "Catecholamine biosynthesis"
xref: Wikipedia:Catecholamines
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33567 ! has primary output
relationship: RO:0004008 CHEBI:33567 ! has primary output

[Term]
id: GO:0042424
name: catecholamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine breakdown" EXACT []
synonym: "catecholamine catabolism" EXACT []
synonym: "catecholamine degradation" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0042402 ! biogenic amine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
relationship: RO:0004009 CHEBI:33567 ! has primary input

[Term]
id: GO:0042427
name: serotonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin anabolism" EXACT []
synonym: "serotonin biosynthesis" EXACT []
synonym: "serotonin formation" EXACT []
synonym: "serotonin synthesis" EXACT []
xref: Wikipedia:Serotonin
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:350546 ! has primary output
relationship: RO:0004008 CHEBI:350546 ! has primary output

[Term]
id: GO:0042428
name: serotonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:350546 ! has primary input or output
relationship: RO:0004007 CHEBI:350546 ! has primary input or output

[Term]
id: GO:0042429
name: serotonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin breakdown" EXACT []
synonym: "serotonin catabolism" EXACT []
synonym: "serotonin degradation" EXACT []
xref: Reactome:R-HSA-380612 "Metabolism of serotonin"
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:350546 ! has primary input
relationship: RO:0004009 CHEBI:350546 ! has primary input

[Term]
id: GO:0042430
name: indole-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah]
synonym: "indole and derivative metabolic process" EXACT []
synonym: "indole and derivative metabolism" EXACT []
synonym: "indole derivative metabolic process" NARROW []
synonym: "indole derivative metabolism" NARROW []
synonym: "indole-containing compound metabolism" EXACT []
synonym: "ketole metabolic process" EXACT []
synonym: "ketole metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:24828 ! has primary input or output indoles
relationship: RO:0004007 CHEBI:24828 ! has primary input or output indoles

[Term]
id: GO:0042435
name: indole-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]
synonym: "indole derivative biosynthesis" EXACT []
synonym: "indole derivative biosynthetic process" EXACT []
synonym: "indole-containing compound anabolism" EXACT []
synonym: "indole-containing compound biosynthesis" EXACT []
synonym: "indole-containing compound formation" EXACT []
synonym: "indole-containing compound synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042430 ! indole-containing compound metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:24828 ! has primary output indoles
relationship: RO:0004008 CHEBI:24828 ! has primary output indoles

[Term]
id: GO:0042436
name: indole-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]
synonym: "indole derivative catabolic process" EXACT []
synonym: "indole derivative catabolism" EXACT []
synonym: "indole-containing compound breakdown" EXACT []
synonym: "indole-containing compound catabolism" EXACT []
synonym: "indole-containing compound degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:24828 ! has primary input indoles
relationship: RO:0004009 CHEBI:24828 ! has primary input indoles

[Term]
id: GO:0042442
name: melatonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl]
synonym: "melatonin breakdown" EXACT []
synonym: "melatonin catabolism" EXACT []
synonym: "melatonin degradation" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0042447 ! hormone catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:16796 ! has primary input
relationship: RO:0004009 CHEBI:16796 ! has primary input

[Term]
id: GO:0042445
name: hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]
subset: goslim_pir
synonym: "cellular hormone metabolic process" RELATED []
synonym: "hormone metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0042446
name: hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]
synonym: "hormone anabolism" EXACT []
synonym: "hormone biosynthesis" EXACT []
synonym: "hormone formation" EXACT []
synonym: "hormone synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042447
name: hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]
synonym: "hormone breakdown" EXACT []
synonym: "hormone catabolism" EXACT []
synonym: "hormone degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042461
name: photoreceptor cell development
namespace: biological_process
def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]
synonym: "photoreceptor morphogenesis" EXACT []
is_a: GO:0048666 ! neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000210 ! results in development of photoreceptor cell
relationship: BFO:0000050 GO:0046530 ! part of photoreceptor cell differentiation
relationship: RO:0002296 CL:0000210 ! results in development of photoreceptor cell

[Term]
id: GO:0042462
name: eye photoreceptor cell development
namespace: biological_process
def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]
is_a: GO:0042461 ! photoreceptor cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell
relationship: BFO:0000050 GO:0001754 ! part of eye photoreceptor cell differentiation
relationship: RO:0002296 CL:0000287 ! results in development of eye photoreceptor cell

[Term]
id: GO:0042478
name: regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "regulation of eye photoreceptor development" EXACT []
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development
relationship: RO:0002211 GO:0042462 ! regulates eye photoreceptor cell development

[Term]
id: GO:0042479
name: positive regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "activation of eye photoreceptor cell development" NARROW []
synonym: "positive regulation of eye photoreceptor development" EXACT []
synonym: "stimulation of eye photoreceptor cell development" NARROW []
synonym: "up regulation of eye photoreceptor cell development" EXACT []
synonym: "up-regulation of eye photoreceptor cell development" EXACT []
synonym: "upregulation of eye photoreceptor cell development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development
relationship: RO:0002213 GO:0042462 ! positively regulates eye photoreceptor cell development

[Term]
id: GO:0042480
name: negative regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "down regulation of eye photoreceptor cell development" EXACT []
synonym: "down-regulation of eye photoreceptor cell development" EXACT []
synonym: "downregulation of eye photoreceptor cell development" EXACT []
synonym: "inhibition of eye photoreceptor cell development" NARROW []
synonym: "negative regulation of eye photoreceptor development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development
relationship: RO:0002212 GO:0042462 ! negatively regulates eye photoreceptor cell development

[Term]
id: GO:0042551
name: neuron maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000540 ! results in maturation of neuron
relationship: BFO:0000050 GO:0048666 ! part of neuron development
relationship: RO:0002299 CL:0000540 ! results in maturation of neuron

[Term]
id: GO:0042552
name: myelination
namespace: biological_process
def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah]
synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429]
xref: Wikipedia:Myelin
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0042562
name: hormone binding
namespace: molecular_function
def: "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042582
name: azurophil granule
namespace: cellular_component
def: "Primary lysosomal granule readily stainable with a Romanowsky stain." [GOC:jl, PMID:17152095, PMID:28717070, PMID:5914694, WIKIPEDIA:Azurophilic_granule]
synonym: "primary granule" EXACT []
is_a: GO:0005766 ! primary lysosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042592
name: homeostatic process
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_mouse
synonym: "activation of homeostatic process" NARROW []
synonym: "homeostasis" EXACT []
synonym: "inhibition of homeostatic process" NARROW []
synonym: "negative regulation of homeostatic process" RELATED []
synonym: "positive regulation of homeostatic process" RELATED []
synonym: "regulation of homeostatic process" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
subset: goslim_pir
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042641
name: actomyosin
namespace: cellular_component
def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
synonym: "actomyosin complex" EXACT []
synonym: "actomyosin structure" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton

[Term]
id: GO:0042644
name: chloroplast nucleoid
namespace: cellular_component
def: "The region of a chloroplast to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
intersection_of: GO:0009295 ! nucleoid
intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma

[Term]
id: GO:0042645
name: mitochondrial nucleoid
namespace: cellular_component
def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular membraneless organelle
intersection_of: GO:0009295 ! nucleoid
intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion
relationship: BFO:0000050 GO:0005759 ! part of mitochondrial matrix

[Term]
id: GO:0042646
name: plastid nucleoid
namespace: cellular_component
def: "The region of a plastid to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0043232 ! intracellular membraneless organelle
intersection_of: GO:0009295 ! nucleoid
intersection_of: BFO:0000050 GO:0009536 ! part of plastid
relationship: BFO:0000050 GO:0009532 ! part of plastid stroma

[Term]
id: GO:0042648
name: chloroplast chromosome
namespace: cellular_component
def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl]
is_a: GO:0009508 ! plastid chromosome
intersection_of: GO:0005694 ! chromosome
intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
relationship: BFO:0000050 GO:0042644 ! part of chloroplast nucleoid

[Term]
id: GO:0042670
name: retinal cone cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell
relationship: RO:0002315 CL:0000573 ! results in acquisition of features of retinal cone cell

[Term]
id: GO:0042692
name: muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]
synonym: "myogenesis" RELATED []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell
relationship: BFO:0000050 GO:0061061 ! part of muscle structure development
relationship: RO:0002315 CL:0000187 ! results in acquisition of features of muscle cell

[Term]
id: GO:0042886
name: amide transport
namespace: biological_process
def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide
relationship: RO:0004009 CHEBI:32988 ! has primary input amide

[Term]
id: GO:0042887
name: amide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]
synonym: "amine/amide/polyamine channel activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:32988 ! has primary input amide
relationship: BFO:0000050 GO:0042886 ! part of amide transport
relationship: RO:0004009 CHEBI:32988 ! has primary input amide

[Term]
id: GO:0042923
name: neuropeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [PMID:10414961, PMID:38337033]
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042981
name: regulation of apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "apoptosis regulator activity" RELATED []
synonym: "regulation of apoptosis" NARROW []
xref: Reactome:R-HSA-169911 "Regulation of Apoptosis"
xref: Reactome:R-HSA-5633008 "TP53 Regulates Transcription of Cell Death Genes"
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006915 ! regulates apoptotic process
relationship: RO:0002211 GO:0006915 ! regulates apoptotic process

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, PMID:16318917]
subset: goslim_agr
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "cell process" BROAD []
synonym: "cellular process" BROAD []
synonym: "cellular projection" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell

[Term]
id: GO:0042996
name: regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport
relationship: RO:0002211 GO:0043001 ! regulates Golgi to plasma membrane protein transport

[Term]
id: GO:0042997
name: negative regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport
relationship: RO:0002212 GO:0043001 ! negatively regulates Golgi to plasma membrane protein transport

[Term]
id: GO:0042998
name: positive regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport
relationship: RO:0002213 GO:0043001 ! positively regulates Golgi to plasma membrane protein transport

[Term]
id: GO:0043001
name: Golgi to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]
is_a: GO:0006893 ! Golgi to plasma membrane transport
is_a: GO:0015031 ! protein transport
is_a: GO:0061951 ! establishment of protein localization to plasma membrane
intersection_of: GO:0015031 ! protein transport
intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, PMID:3077060]
subset: goslim_pir
synonym: "nerve fiber" RELATED [GOC:dph]
synonym: "neurite" NARROW []
synonym: "neuron process" EXACT []
synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889]
synonym: "neuronal cell projection" EXACT []
xref: NIF_Subcellular:sao867568886
is_a: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: BFO:0000050 CL:0000540 ! part of neuron
relationship: BFO:0000050 CL:0000540 ! part of neuron
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa

[Term]
id: GO:0043009
name: chordate embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching
relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata

[Term]
id: GO:0043010
name: camera-type eye development
namespace: biological_process
def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001654 ! eye development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000019 ! results in development of camera-type eye
relationship: RO:0002296 UBERON:0000019 ! results in development of camera-type eye

[Term]
id: GO:0043011
name: myeloid dendritic cell differentiation
namespace: biological_process
def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl]
xref: Wikipedia:Dendritic_cell
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002573 ! myeloid leukocyte differentiation
is_a: GO:0097028 ! dendritic cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000782 ! results in acquisition of features of myeloid dendritic cell
relationship: RO:0002315 CL:0000782 ! results in acquisition of features of myeloid dendritic cell

[Term]
id: GO:0043021
name: ribonucleoprotein complex binding
namespace: molecular_function
def: "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]
subset: goslim_pir
synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk]
synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk]
synonym: "RNP binding" EXACT []
is_a: GO:0044877 ! protein-containing complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex
relationship: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex

[Term]
id: GO:0043022
name: ribosome binding
namespace: molecular_function
def: "Binding to a ribosome." [GOC:go_curators]
synonym: "ribosome receptor activity" NARROW []
is_a: GO:0043021 ! ribonucleoprotein complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0005840 ! has primary input ribosome
relationship: RO:0004009 GO:0005840 ! has primary input ribosome

[Term]
id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "neuron cell body" EXACT []
synonym: "neuronal cell soma" EXACT []
xref: NIF_Subcellular:sao1044911821
xref: Wikipedia:Soma_(biology)
is_a: GO:0044297 ! cell body
intersection_of: GO:0044297 ! cell body
intersection_of: BFO:0000050 CL:0000540 ! part of neuron
relationship: BFO:0000050 GO:0036477 ! part of somatodendritic compartment

[Term]
id: GO:0043029
name: T cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149]
comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "T lymphocyte homeostasis" EXACT []
synonym: "T-cell homeostasis" EXACT []
synonym: "T-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000084 ! acts on population of T cell
relationship: RO:0012003 CL:0000084 ! acts on population of T cell

[Term]
id: GO:0043030
name: regulation of macrophage activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl]
synonym: "regulation of macrophage polarization" EXACT []
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042116 ! regulates macrophage activation
relationship: RO:0002211 GO:0042116 ! regulates macrophage activation

[Term]
id: GO:0043031
name: negative regulation of macrophage activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl]
synonym: "down regulation of macrophage activation" EXACT []
synonym: "down-regulation of macrophage activation" EXACT []
synonym: "downregulation of macrophage activation" EXACT []
synonym: "inhibition of macrophage activation" NARROW []
synonym: "negative regulation of macrophage polarization" EXACT []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042116 ! negatively regulates macrophage activation
relationship: RO:0002212 GO:0042116 ! negatively regulates macrophage activation

[Term]
id: GO:0043032
name: positive regulation of macrophage activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl]
synonym: "activation of macrophage activation" NARROW []
synonym: "positive regulation of macrophage polarization" EXACT []
synonym: "stimulation of macrophage activation" NARROW []
synonym: "up regulation of macrophage activation" EXACT []
synonym: "up-regulation of macrophage activation" EXACT []
synonym: "upregulation of macrophage activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042116 ! positively regulates macrophage activation
relationship: RO:0002213 GO:0042116 ! positively regulates macrophage activation

[Term]
id: GO:0043038
name: amino acid activation
namespace: biological_process
def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl]
is_a: GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0043039
name: tRNA aminoacylation
namespace: biological_process
def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah]
synonym: "amino acid activation" RELATED []
synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah]
synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah]
synonym: "tRNA charging" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0043038 ! amino acid activation

[Term]
id: GO:0043043
name: peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl]
synonym: "peptide anabolism" EXACT []
synonym: "peptide biosynthesis" EXACT []
synonym: "peptide formation" EXACT []
synonym: "peptide synthesis" EXACT []
xref: Reactome:R-HSA-9037628 "Rhesus blood group biosynthesis"
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:60466 ! has primary output peptide zwitterion
relationship: RO:0004008 CHEBI:60466 ! has primary output peptide zwitterion

[Term]
id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: goslim_prokaryote
synonym: "extracellular structure organisation" EXACT []
synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005576 ! results in organization of extracellular region
relationship: RO:0002592 GO:0005576 ! results in organization of extracellular region

[Term]
id: GO:0043065
name: positive regulation of apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
subset: goslim_chembl
synonym: "activation of apoptosis" NARROW []
synonym: "positive regulation of apoptosis" NARROW []
synonym: "pro-apoptosis" RELATED []
synonym: "stimulation of apoptosis" NARROW []
synonym: "up regulation of apoptosis" EXACT []
synonym: "up-regulation of apoptosis" EXACT []
synonym: "upregulation of apoptosis" EXACT []
xref: Reactome:R-HSA-193648 "NRAGE signals death through JNK"
xref: Reactome:R-HSA-205043 "NRIF signals cell death from the nucleus"
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043068 ! positive regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006915 ! positively regulates apoptotic process
relationship: RO:0002213 GO:0006915 ! positively regulates apoptotic process

[Term]
id: GO:0043066
name: negative regulation of apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "anti-apoptosis" EXACT []
synonym: "apoptosis inhibitor activity" RELATED []
synonym: "down regulation of apoptosis" EXACT []
synonym: "down-regulation of apoptosis" EXACT []
synonym: "downregulation of apoptosis" EXACT []
synonym: "inhibition of apoptosis" NARROW []
synonym: "negative regulation of apoptosis" NARROW []
synonym: "pro-survival" RELATED []
xref: Reactome:R-HSA-193639 "p75NTR signals via NF-kB"
xref: Reactome:R-HSA-211728 "Regulation of PAK-2p34 activity by PS-GAP/RHG10"
xref: Reactome:R-HSA-211733 "Regulation of activated PAK-2p34 by proteasome mediated degradation"
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043069 ! negative regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006915 ! negatively regulates apoptotic process
relationship: RO:0002212 GO:0006915 ! negatively regulates apoptotic process

[Term]
id: GO:0043067
name: regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043070
def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0012501 ! regulates programmed cell death
relationship: RO:0002211 GO:0012501 ! regulates programmed cell death

[Term]
id: GO:0043068
name: positive regulation of programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "activation of programmed cell death" NARROW []
synonym: "positive regulation of non-apoptotic programmed cell death" NARROW []
synonym: "stimulation of programmed cell death" NARROW []
synonym: "up regulation of programmed cell death" EXACT []
synonym: "up-regulation of programmed cell death" EXACT []
synonym: "upregulation of programmed cell death" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0012501 ! positively regulates programmed cell death
relationship: RO:0002213 GO:0012501 ! positively regulates programmed cell death

[Term]
id: GO:0043069
name: negative regulation of programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "down regulation of programmed cell death" EXACT []
synonym: "down-regulation of programmed cell death" EXACT []
synonym: "downregulation of programmed cell death" EXACT []
synonym: "inhibition of programmed cell death" NARROW []
synonym: "negative regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0012501 ! negatively regulates programmed cell death
relationship: RO:0002212 GO:0012501 ! negatively regulates programmed cell death

[Term]
id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators]
synonym: "germ-cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: BFO:0000050 CL:0000586 ! part of germ cell
relationship: BFO:0000050 CL:0000586 ! part of germ cell

[Term]
id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, PMID:30784960]
subset: goslim_synapse
xref: NIF_Subcellular:sao243541954
is_a: GO:0005576 ! extracellular region
relationship: RO:0002220 GO:0045202 ! adjacent to synapse

[Term]
id: GO:0043085
name: positive regulation of catalytic activity
namespace: biological_process
def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
synonym: "activation of enzyme activity" NARROW []
synonym: "activation of metalloenzyme activity" NARROW []
synonym: "positive regulation of enzyme activity" EXACT [GOC:tb]
synonym: "positive regulation of metalloenzyme activity" NARROW []
synonym: "stimulation of enzyme activity" NARROW []
synonym: "stimulation of metalloenzyme activity" NARROW []
synonym: "up regulation of enzyme activity" EXACT []
synonym: "up regulation of metalloenzyme activity" NARROW []
synonym: "up-regulation of enzyme activity" EXACT []
synonym: "up-regulation of metalloenzyme activity" NARROW []
synonym: "upregulation of enzyme activity" EXACT []
synonym: "upregulation of metalloenzyme activity" NARROW []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003824 ! positively regulates catalytic activity
relationship: RO:0002213 GO:0003824 ! positively regulates catalytic activity

[Term]
id: GO:0043086
name: negative regulation of catalytic activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
subset: gocheck_obsoletion_candidate
synonym: "down regulation of enzyme activity" EXACT []
synonym: "down regulation of metalloenzyme activity" NARROW []
synonym: "down-regulation of enzyme activity" EXACT []
synonym: "down-regulation of metalloenzyme activity" EXACT []
synonym: "downregulation of enzyme activity" EXACT []
synonym: "downregulation of metalloenzyme activity" NARROW []
synonym: "inhibition of enzyme activity" NARROW []
synonym: "inhibition of metalloenzyme activity" NARROW []
synonym: "negative regulation of enzyme activity" EXACT [GOC:tb]
synonym: "negative regulation of metalloenzyme activity" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003824 ! negatively regulates catalytic activity
relationship: RO:0002212 GO:0003824 ! negatively regulates catalytic activity

[Term]
id: GO:0043143
name: regulation of translation by machinery localization
namespace: biological_process
def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]
synonym: "establishment and maintenance of translational machinery localization" EXACT []
synonym: "establishment and maintenance of translational protein localization" EXACT []
synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah]
synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb]
synonym: "translational protein localization" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: BFO:0000050 GO:0006412 ! part of translation
relationship: BFO:0000050 GO:0006412 ! part of translation

[Term]
id: GO:0043167
name: ion binding
namespace: molecular_function
def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
synonym: "atom binding" RELATED []
is_a: GO:0036094 ! small molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:24870 ! has primary input ion
relationship: RO:0004009 CHEBI:24870 ! has primary input ion

[Term]
id: GO:0043168
name: anion binding
namespace: molecular_function
def: "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]
is_a: GO:0043167 ! ion binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:22563 ! has primary input anion
relationship: RO:0004009 CHEBI:22563 ! has primary input anion

[Term]
id: GO:0043169
name: cation binding
namespace: molecular_function
def: "Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]
is_a: GO:0043167 ! ion binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:36916 ! has primary input cation
relationship: RO:0004009 CHEBI:36916 ! has primary input cation

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0034960
alt_id: GO:0043283
alt_id: GO:0044259
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
synonym: "multicellular organismal macromolecule metabolic process" NARROW []
synonym: "organismal macromolecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33694 ! has primary input or output biomacromolecule
relationship: RO:0004007 CHEBI:33694 ! has primary input or output biomacromolecule

[Term]
id: GO:0043171
name: peptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]
synonym: "peptide breakdown" EXACT []
synonym: "peptide catabolism" EXACT []
synonym: "peptide degradation" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion

[Term]
id: GO:0043176
name: amine binding
namespace: molecular_function
def: "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group." [GOC:jl]
subset: goslim_pir
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine

[Term]
id: GO:0043177
name: organic acid binding
namespace: molecular_function
def: "Binding to an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732]
is_a: GO:0036094 ! small molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:64709 ! has primary input organic acid
relationship: RO:0004009 CHEBI:64709 ! has primary input organic acid

[Term]
id: GO:0043184
name: vascular endothelial growth factor receptor 2 binding
namespace: molecular_function
def: "Binding to a vascular endothelial growth factor receptor 2." [GOC:st]
synonym: "Flk-1 binding" EXACT []
synonym: "KDR binding" BROAD []
synonym: "kinase domain region binding" EXACT []
synonym: "VEGF receptor 2 binding" EXACT []
synonym: "VEGFR 2 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000002112 ! has primary input vascular endothelial growth factor receptor 2
relationship: RO:0004009 PR:000002112 ! has primary input vascular endothelial growth factor receptor 2

[Term]
id: GO:0043200
name: response to amino acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg]
synonym: "response to amino acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
relationship: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion

[Term]
id: GO:0043207
name: response to external biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0043209
name: myelin sheath
namespace: cellular_component
def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin]
synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204]
synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730]
synonym: "Schwann cell myelin sheath" NARROW []
xref: FMA:62983
xref: NIF_Subcellular:sao593830697
xref: Wikipedia:Myelin
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000125 ! part of glial cell

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
xref: NIF_Subcellular:sao1539965131
xref: Wikipedia:Organelle
is_a: GO:0110165 ! cellular anatomical structure
disjoint_from: GO:0044423 ! virion component

[Term]
id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao414196390
is_a: GO:0043226 ! organelle
intersection_of: GO:0043226 ! organelle
intersection_of: BFO:0000051 GO:0016020 ! has part membrane
disjoint_from: GO:0043228 ! membraneless organelle
relationship: BFO:0000051 GO:0016020 ! has part membrane

[Term]
id: GO:0043228
name: membraneless organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_mouse
synonym: "biological condensate" RELATED []
synonym: "membrane-less organelle" EXACT []
synonym: "non-membrane-bounded organelle" EXACT []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_pir
is_a: GO:0043226 ! organelle
intersection_of: GO:0043226 ! organelle
intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure
disjoint_from: GO:0043230 ! extracellular organelle
relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: goslim_pir
is_a: GO:0043226 ! organelle
intersection_of: GO:0043226 ! organelle
intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region
relationship: BFO:0000050 GO:0005576 ! part of extracellular region

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle
intersection_of: GO:0043227 ! membrane-bounded organelle
intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure

[Term]
id: GO:0043232
name: intracellular membraneless organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "intracellular non-membrane-bounded organelle" EXACT []
synonym: "intracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! membraneless organelle
is_a: GO:0043229 ! intracellular organelle
intersection_of: GO:0043228 ! membraneless organelle
intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure

[Term]
id: GO:0043233
name: organelle lumen
namespace: cellular_component
def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]
subset: goslim_mouse
is_a: GO:0031974 ! membrane-enclosed lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: BFO:0000050 GO:0043226 ! part of organelle
relationship: BFO:0000050 GO:0043226 ! part of organelle

[Term]
id: GO:0043235
name: receptor complex
namespace: cellular_component
def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity
relationship: RO:0002215 GO:0038023 ! capable of signaling receptor activity

[Term]
id: GO:0043242
name: negative regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "down regulation of protein complex disassembly" EXACT []
synonym: "down-regulation of protein complex disassembly" EXACT []
synonym: "downregulation of protein complex disassembly" EXACT []
synonym: "inhibition of protein complex disassembly" NARROW []
synonym: "negative regulation of protein complex disassembly" RELATED []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly
relationship: RO:0002212 GO:0032984 ! negatively regulates protein-containing complex disassembly

[Term]
id: GO:0043243
name: positive regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "activation of protein complex disassembly" NARROW []
synonym: "positive regulation of protein complex disassembly" RELATED []
synonym: "stimulation of protein complex disassembly" NARROW []
synonym: "up regulation of protein complex disassembly" EXACT []
synonym: "up-regulation of protein complex disassembly" EXACT []
synonym: "upregulation of protein complex disassembly" EXACT []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly
relationship: RO:0002213 GO:0032984 ! positively regulates protein-containing complex disassembly

[Term]
id: GO:0043244
name: regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "regulation of protein complex disassembly" RELATED []
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly
relationship: RO:0002211 GO:0032984 ! regulates protein-containing complex disassembly

[Term]
id: GO:0043249
name: erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl]
synonym: "RBC maturation" EXACT [CL:0000232]
synonym: "red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000232 ! results in maturation of erythrocyte
relationship: BFO:0000050 GO:0048821 ! part of erythrocyte development
relationship: RO:0002299 CL:0000232 ! results in maturation of erythrocyte

[Term]
id: GO:0043253
name: chloroplast ribosome
namespace: cellular_component
def: "A ribosome contained within a chloroplast." [GOC:ecd]
is_a: GO:0009547 ! plastid ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma

[Term]
id: GO:0043254
name: regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]
synonym: "regulation of protein complex assembly" RELATED []
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly
relationship: RO:0002211 GO:0065003 ! regulates protein-containing complex assembly

[Term]
id: GO:0043255
name: regulation of carbohydrate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]
synonym: "regulation of carbohydrate anabolism" EXACT []
synonym: "regulation of carbohydrate biosynthesis" EXACT []
synonym: "regulation of carbohydrate formation" EXACT []
synonym: "regulation of carbohydrate synthesis" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process
relationship: RO:0002211 GO:0016051 ! regulates carbohydrate biosynthetic process

[Term]
id: GO:0043264
name: extracellular membraneless organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]
synonym: "extracellular non-membrane-bounded organelle" EXACT []
synonym: "extracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! membraneless organelle
is_a: GO:0043230 ! extracellular organelle
intersection_of: GO:0043228 ! membraneless organelle
intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region

[Term]
id: GO:0043269
name: regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of ion transport" BROAD []
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006811 ! regulates monoatomic ion transport
relationship: RO:0002211 GO:0006811 ! regulates monoatomic ion transport

[Term]
id: GO:0043270
name: positive regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "activation of ion transport" NARROW []
synonym: "stimulation of ion transport" NARROW []
synonym: "up regulation of ion transport" EXACT []
synonym: "up-regulation of ion transport" EXACT []
synonym: "upregulation of ion transport" EXACT []
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport
relationship: RO:0002213 GO:0006811 ! positively regulates monoatomic ion transport

[Term]
id: GO:0043271
name: negative regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of ion transport" EXACT []
synonym: "down-regulation of ion transport" EXACT []
synonym: "downregulation of ion transport" EXACT []
synonym: "inhibition of ion transport" NARROW []
synonym: "negative regulation of ion transport" BROAD []
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport
relationship: RO:0002212 GO:0006811 ! negatively regulates monoatomic ion transport

[Term]
id: GO:0043292
name: contractile muscle fiber
namespace: cellular_component
def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]
synonym: "contractile fibre" EXACT []
is_a: GO:0043232 ! intracellular membraneless organelle
is_a: GO:0099512 ! supramolecular fiber
relationship: BFO:0000050 CL:0000187 ! part of muscle cell
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0043296
name: apical junction complex
namespace: cellular_component
def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]
synonym: "apical cell junction complex" EXACT [GOC:mah]
synonym: "apical junction" EXACT []
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0043297
name: apical junction assembly
namespace: biological_process
def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]
synonym: "apical junction complex assembly" EXACT [GOC:mah]
is_a: GO:0007043 ! cell-cell junction assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0043296 ! results in assembly of apical junction complex
relationship: RO:0002588 GO:0043296 ! results in assembly of apical junction complex

[Term]
id: GO:0043362
name: nucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl]
synonym: "nucleate RBC maturation" EXACT [CL:0000232]
synonym: "nucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte
relationship: BFO:0000050 GO:0048823 ! part of nucleate erythrocyte development
relationship: RO:0002299 CL:0000562 ! results in maturation of nucleate erythrocyte

[Term]
id: GO:0043363
name: nucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl]
synonym: "nucleate RBC differentiation" EXACT [CL:0000232]
synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte
relationship: RO:0002315 CL:0000562 ! results in acquisition of features of nucleate erythrocyte

[Term]
id: GO:0043385
name: mycotoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl]
synonym: "mycotoxin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0043386
name: mycotoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl]
synonym: "mycotoxin anabolism" EXACT []
synonym: "mycotoxin biosynthesis" EXACT []
synonym: "mycotoxin formation" EXACT []
synonym: "mycotoxin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043388
name: positive regulation of DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "activation of DNA binding" NARROW []
synonym: "stimulation of DNA binding" NARROW []
synonym: "up regulation of DNA binding" EXACT []
synonym: "up-regulation of DNA binding" EXACT []
synonym: "upregulation of DNA binding" EXACT []
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003677 ! positively regulates DNA binding
relationship: RO:0002213 GO:0003677 ! positively regulates DNA binding

[Term]
id: GO:0043392
name: negative regulation of DNA binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "down regulation of DNA binding" EXACT []
synonym: "down-regulation of DNA binding" EXACT []
synonym: "downregulation of DNA binding" EXACT []
synonym: "inhibition of DNA binding" NARROW []
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:0051101 ! regulation of DNA binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003677 ! negatively regulates DNA binding
relationship: RO:0002212 GO:0003677 ! negatively regulates DNA binding

[Term]
id: GO:0043393
name: regulation of protein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0005515 ! regulates protein binding
relationship: RO:0002211 GO:0005515 ! regulates protein binding

[Term]
id: GO:0043412
name: macromolecule modification
namespace: biological_process
def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]
subset: gocheck_obsoletion_candidate
subset: goslim_pir
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043434
name: response to peptide hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
synonym: "response to peptide hormone stimulus" EXACT [GOC:dos]
synonym: "response to polypeptide hormone stimulus" EXACT []
is_a: GO:0009725 ! response to hormone
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:25905 ! has primary input
relationship: RO:0004009 CHEBI:25905 ! has primary input

[Term]
id: GO:0043436
name: oxoacid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]
synonym: "keto acid metabolic process" EXACT []
synonym: "keto acid metabolism" EXACT []
synonym: "ketoacid metabolic process" EXACT []
synonym: "ketoacid metabolism" EXACT []
synonym: "oxo acid metabolic process" EXACT []
synonym: "oxo acid metabolism" EXACT []
synonym: "oxoacid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:35406 ! has primary input or output oxoanion
relationship: RO:0004007 CHEBI:35406 ! has primary input or output oxoanion

[Term]
id: GO:0043455
name: regulation of secondary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
synonym: "regulation of secondary metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019748 ! regulates secondary metabolic process
relationship: RO:0002211 GO:0019748 ! regulates secondary metabolic process

[Term]
id: GO:0043462
name: regulation of ATP-dependent activity
namespace: biological_process
def: "Any process that modulates the rate of an ATP-dependent activity." [GOC:jl]
subset: gocheck_obsoletion_candidate
synonym: "regulation of adenosinetriphosphatase activity" EXACT []
synonym: "regulation of ATPase activity" EXACT []
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0140657 ! regulates ATP-dependent activity
relationship: RO:0002211 GO:0140657 ! regulates ATP-dependent activity

[Term]
id: GO:0043470
name: regulation of carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process
relationship: RO:0002211 GO:0016052 ! regulates carbohydrate catabolic process

[Term]
id: GO:0043473
name: pigmentation
namespace: biological_process
def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0008150 ! biological_process
relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms

[Term]
id: GO:0043476
name: pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl]
synonym: "pigment accumulation in response to external stimulus" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0043482
name: cellular pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl]
is_a: GO:0033059 ! cellular pigmentation
is_a: GO:0043476 ! pigment accumulation
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0043500
name: muscle adaptation
namespace: biological_process
def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
subset: goslim_pir
synonym: "muscle plasticity" RELATED []
is_a: GO:0003012 ! muscle system process
is_a: GO:0050896 ! response to stimulus
relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue

[Term]
id: GO:0043501
name: skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue
relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue

[Term]
id: GO:0043502
name: regulation of muscle adaptation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle]
synonym: "regulation of muscle plasticity" RELATED []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043500 ! regulates muscle adaptation
relationship: RO:0002211 GO:0043500 ! regulates muscle adaptation

[Term]
id: GO:0043523
name: regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of neuronal cells" EXACT []
synonym: "regulation of apoptosis of neurons" EXACT []
synonym: "regulation of neuron apoptosis" NARROW []
synonym: "regulation of neuron programmed cell death" EXACT []
synonym: "regulation of neuronal cell programmed cell death" EXACT []
synonym: "regulation of programmed cell death of neuronal cells" EXACT []
synonym: "regulation of programmed cell death, neurons" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051402 ! regulates neuron apoptotic process
relationship: RO:0002211 GO:0051402 ! regulates neuron apoptotic process

[Term]
id: GO:0043524
name: negative regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "down regulation of neuron apoptosis" EXACT []
synonym: "down-regulation of neuron apoptosis" EXACT []
synonym: "downregulation of neuron apoptosis" EXACT []
synonym: "inhibition of neuron apoptosis" NARROW []
synonym: "negative regulation of neuron apoptosis" NARROW []
synonym: "negative regulation of programmed cell death, neurons" EXACT []
synonym: "neuron survival" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process
relationship: RO:0002212 GO:0051402 ! negatively regulates neuron apoptotic process

[Term]
id: GO:0043525
name: positive regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "activation of neuron apoptosis" NARROW []
synonym: "positive regulation of neuron apoptosis" NARROW []
synonym: "positive regulation of programmed cell death, neurons" EXACT []
synonym: "stimulation of neuron apoptosis" NARROW []
synonym: "up regulation of neuron apoptosis" EXACT []
synonym: "up-regulation of neuron apoptosis" EXACT []
synonym: "upregulation of neuron apoptosis" EXACT []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process
relationship: RO:0002213 GO:0051402 ! positively regulates neuron apoptotic process

[Term]
id: GO:0043534
name: blood vessel endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264]
is_a: GO:0043542 ! endothelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000071 ! results in movement of blood vessel endothelial cell
relationship: RO:0002565 CL:0000071 ! results in movement of blood vessel endothelial cell

[Term]
id: GO:0043535
name: regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
is_a: GO:0010594 ! regulation of endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043534 ! regulates blood vessel endothelial cell migration
relationship: RO:0002211 GO:0043534 ! regulates blood vessel endothelial cell migration

[Term]
id: GO:0043536
name: positive regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "activation of blood vessel endothelial cell migration" NARROW []
synonym: "stimulation of blood vessel endothelial cell migration" NARROW []
synonym: "up regulation of blood vessel endothelial cell migration" EXACT []
synonym: "up-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "upregulation of blood vessel endothelial cell migration" EXACT []
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043534 ! positively regulates blood vessel endothelial cell migration
relationship: RO:0002213 GO:0043534 ! positively regulates blood vessel endothelial cell migration

[Term]
id: GO:0043537
name: negative regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "down regulation of blood vessel endothelial cell migration" EXACT []
synonym: "down-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "downregulation of blood vessel endothelial cell migration" EXACT []
synonym: "inhibition of blood vessel endothelial cell migration" NARROW []
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043534 ! negatively regulates blood vessel endothelial cell migration
relationship: RO:0002212 GO:0043534 ! negatively regulates blood vessel endothelial cell migration

[Term]
id: GO:0043542
name: endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell
relationship: RO:0002565 CL:0000115 ! results in movement of endothelial cell

[Term]
id: GO:0043555
name: regulation of translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
synonym: "translational stress response" EXACT []
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002211 GO:0006412 ! regulates translation
relationship: BFO:0000050 GO:0033554 ! part of cellular response to stress

[Term]
id: GO:0043556
name: regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
is_a: GO:0032055 ! negative regulation of translation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress
intersection_of: RO:0002212 GO:0006412 ! negatively regulates translation
relationship: BFO:0000050 GO:0034599 ! part of cellular response to oxidative stress

[Term]
id: GO:0043558
name: regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl]
synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0043555 ! regulation of translation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation

[Term]
id: GO:0043572
name: plastid fission
namespace: biological_process
def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl]
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: GOREL:0002004 GO:0009536 ! results in fission of plastid
relationship: GOREL:0002004 GO:0009536 ! results in fission of plastid

[Term]
id: GO:0043576
name: regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system
relationship: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange by respiratory system

[Term]
id: GO:0043586
name: tongue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]
synonym: "glossa development" NARROW []
synonym: "lingua development" NARROW []
is_a: GO:0007423 ! sensory organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001723 ! results in development of tongue
relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata <chordates>
relationship: RO:0002296 UBERON:0001723 ! results in development of tongue

[Term]
id: GO:0043587
name: tongue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]
synonym: "glossa morphogenesis" NARROW []
synonym: "lingua morphogenesis" EXACT []
is_a: GO:0090596 ! sensory organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001723 ! results in morphogenesis of tongue
relationship: BFO:0000050 GO:0043586 ! part of tongue development
relationship: RO:0002298 UBERON:0001723 ! results in morphogenesis of tongue

[Term]
id: GO:0043588
name: skin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
synonym: "animal skin development" EXACT []
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002097 ! results in development of skin of body
relationship: RO:0002296 UBERON:0002097 ! results in development of skin of body

[Term]
id: GO:0043589
name: skin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body
relationship: BFO:0000050 GO:0043588 ! part of skin development
relationship: RO:0002298 UBERON:0002097 ! results in morphogenesis of skin of body

[Term]
id: GO:0043603
name: amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "amide metabolism" EXACT []
synonym: "cellular amide metabolic process" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:32988 ! has primary input or output amide
relationship: RO:0004007 CHEBI:32988 ! has primary input or output amide

[Term]
id: GO:0043604
name: amide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0043603 ! amide metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:32988 ! has primary output amide
relationship: RO:0004008 CHEBI:32988 ! has primary output amide

[Term]
id: GO:0043605
name: amide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]
synonym: "cellular amide catabolic process" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0043603 ! amide metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004008 CHEBI:32988 ! has primary output amide
relationship: RO:0004008 CHEBI:32988 ! has primary output amide

[Term]
id: GO:0043615
name: astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators]
synonym: "astrocyte migration" EXACT []
synonym: "astrocytic glial cell migration" EXACT []
is_a: GO:0008347 ! glial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000127 ! results in movement of astrocyte
relationship: RO:0002565 CL:0000127 ! results in movement of astrocyte

[Term]
id: GO:0043648
name: dicarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
synonym: "dicarboxylate metabolic process" EXACT []
synonym: "dicarboxylate metabolism" EXACT []
synonym: "dicarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:35693 ! has primary input or output dicarboxylic acid anion
relationship: RO:0004007 CHEBI:35693 ! has primary input or output dicarboxylic acid anion

[Term]
id: GO:0043649
name: dicarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "dicarboxylate catabolic process" EXACT []
synonym: "dicarboxylate catabolism" EXACT []
synonym: "dicarboxylic acid breakdown" EXACT []
synonym: "dicarboxylic acid catabolism" EXACT []
synonym: "dicarboxylic acid degradation" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion
relationship: RO:0004009 CHEBI:35693 ! has primary input dicarboxylic acid anion

[Term]
id: GO:0043650
name: dicarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "dicarboxylate biosynthesis" EXACT []
synonym: "dicarboxylate biosynthetic process" EXACT []
synonym: "dicarboxylic acid anabolism" EXACT []
synonym: "dicarboxylic acid biosynthesis" EXACT []
synonym: "dicarboxylic acid formation" EXACT []
synonym: "dicarboxylic acid synthesis" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:35693 ! has primary output dicarboxylic acid anion
relationship: RO:0004008 CHEBI:35693 ! has primary output dicarboxylic acid anion

[Term]
id: GO:0043903
name: regulation of biological process involved in symbiotic interaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl]
comment: regulation of interspecies interactions between organisms
synonym: "regulation of interspecies interactions between organisms" BROAD []
synonym: "regulation of symbiosis, encompassing mutualism through parasitism" RELATED []
synonym: "regulation of symbiotic process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044403 ! regulates biological process involved in symbiotic interaction
relationship: RO:0002211 GO:0044403 ! regulates biological process involved in symbiotic interaction

[Term]
id: GO:0043931
name: ossification involved in bone maturation
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo]
synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034]
synonym: "ossification involved in skeletal development" EXACT [GOC:dph]
is_a: GO:0001503 ! ossification
intersection_of: GO:0001503 ! ossification
intersection_of: BFO:0000050 GO:0070977 ! part of bone maturation
relationship: BFO:0000050 GO:0070977 ! part of bone maturation

[Term]
id: GO:0043932
name: ossification involved in bone remodeling
namespace: biological_process
def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo]
synonym: "ossification involved in bone remodelling" EXACT []
is_a: GO:0001503 ! ossification
intersection_of: GO:0001503 ! ossification
intersection_of: BFO:0000050 GO:0046849 ! part of bone remodeling
relationship: BFO:0000050 GO:0046849 ! part of bone remodeling

[Term]
id: GO:0043933
name: protein-containing complex organization
namespace: biological_process
alt_id: GO:0034600
alt_id: GO:0034621
alt_id: GO:0071822
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]
synonym: "cellular macromolecular complex organization" RELATED []
synonym: "cellular macromolecular complex subunit organisation" RELATED []
synonym: "cellular macromolecular complex subunit organization" RELATED []
synonym: "macromolecular complex organization" RELATED []
synonym: "macromolecular complex subunit organisation" RELATED []
synonym: "macromolecular complex subunit organization" RELATED []
synonym: "protein complex subunit organisation" EXACT [GOC:mah]
synonym: "protein complex subunit organization" EXACT []
synonym: "protein-containing complex subunit organization" RELATED []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0032991 ! results in organization of protein-containing complex
relationship: RO:0002592 GO:0032991 ! results in organization of protein-containing complex
created_by: mah
creation_date: 2010-09-08T10:01:42Z

[Term]
id: GO:0043934
name: sporulation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
subset: goslim_metagenomics
subset: goslim_yeast
xref: Wikipedia:Spore
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0043935
name: sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0034293 ! sexual sporulation
intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle

[Term]
id: GO:0043936
name: asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and desiccation resistance, and/or for reproduction." [GOC:pamgo_curators]
synonym: "asexual reproduction resulting in the formation of a cellular spore" EXACT [GOC:di]
synonym: "asexual sporulation resulting in the formation of a viable spore" BROAD [GOC:di]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0043937
name: regulation of sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043934 ! regulates sporulation
relationship: RO:0002211 GO:0043934 ! regulates sporulation

[Term]
id: GO:0043938
name: positive regulation of sporulation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043934 ! positively regulates sporulation
relationship: RO:0002213 GO:0043934 ! positively regulates sporulation

[Term]
id: GO:0043939
name: negative regulation of sporulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043934 ! negatively regulates sporulation
relationship: RO:0002212 GO:0043934 ! negatively regulates sporulation

[Term]
id: GO:0043940
name: regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]
is_a: GO:0034306 ! regulation of sexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043935 ! regulates sexual sporulation resulting in formation of a cellular spore
relationship: RO:0002211 GO:0043935 ! regulates sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043943
name: regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043936 ! regulates asexual sporulation resulting in formation of a cellular spore
relationship: RO:0002211 GO:0043936 ! regulates asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0044001
name: migration in host
namespace: biological_process
def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "migration within host" EXACT []
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044057
name: regulation of system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003008 ! regulates system process
relationship: RO:0002211 GO:0003008 ! regulates system process

[Term]
id: GO:0044058
name: regulation of digestive system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022600 ! regulates digestive system process
relationship: RO:0002211 GO:0022600 ! regulates digestive system process

[Term]
id: GO:0044060
name: regulation of endocrine process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]
synonym: "regulation of endocrine system process" EXACT []
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050886 ! regulates endocrine process
relationship: RO:0002211 GO:0050886 ! regulates endocrine process

[Term]
id: GO:0044065
name: regulation of respiratory system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003016 ! regulates respiratory system process
relationship: RO:0002211 GO:0003016 ! regulates respiratory system process

[Term]
id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
alt_id: GO:0071843
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular component biogenesis at cellular level" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0044087
name: regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
subset: gocheck_do_not_annotate
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044085 ! regulates cellular component biogenesis
relationship: RO:0002211 GO:0044085 ! regulates cellular component biogenesis

[Term]
id: GO:0044088
name: regulation of vacuole organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007033 ! regulates vacuole organization
relationship: RO:0002211 GO:0007033 ! regulates vacuole organization

[Term]
id: GO:0044089
name: positive regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis
relationship: RO:0002213 GO:0044085 ! positively regulates cellular component biogenesis

[Term]
id: GO:0044090
name: positive regulation of vacuole organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007033 ! positively regulates vacuole organization
relationship: RO:0002213 GO:0007033 ! positively regulates vacuole organization

[Term]
id: GO:0044091
name: membrane biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl]
is_a: GO:0044085 ! cellular component biogenesis
intersection_of: GO:0044085 ! cellular component biogenesis
intersection_of: RO:0004008 GO:0016020 ! has primary output membrane
relationship: RO:0004008 GO:0016020 ! has primary output membrane

[Term]
id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003674 ! negatively regulates molecular_function
relationship: RO:0002212 GO:0003674 ! negatively regulates molecular_function
creation_date: 2009-04-21T04:07:27Z

[Term]
id: GO:0044093
name: positive regulation of molecular function
namespace: biological_process
def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_obsoletion_candidate
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003674 ! positively regulates molecular_function
relationship: RO:0002213 GO:0003674 ! positively regulates molecular_function
creation_date: 2009-04-21T04:11:06Z

[Term]
id: GO:0044111
name: formation of structure involved in a symbiotic process
namespace: biological_process
alt_id: GO:0044115
alt_id: GO:0044152
def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
synonym: "development during symbiotic interaction" RELATED [GOC:dph]
synonym: "development involved in symbiotic interaction" RELATED []
synonym: "development of symbiont during interaction with host" RELATED [GOC:dph]
synonym: "development of symbiont involved in interaction with host" RELATED []
synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph]
synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW []
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms
created_by: jl
creation_date: 2009-07-30T02:26:46Z

[Term]
id: GO:0044114
name: development of symbiont in host
namespace: biological_process
alt_id: GO:0044122
alt_id: GO:0044124
def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'biological process involved in interaction with host ; GO:0051701.
synonym: "development of symbiont in host intercellular space" NARROW []
synonym: "development of symbiont in host vascular tissue" NARROW []
is_a: GO:0044111 ! formation of structure involved in a symbiotic process
created_by: jl
creation_date: 2009-07-30T03:39:25Z

[Term]
id: GO:0044127
name: regulation of development of symbiont in host
namespace: biological_process
def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'.
is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044114 ! regulates development of symbiont in host
relationship: RO:0002211 GO:0044114 ! regulates development of symbiont in host
created_by: jl
creation_date: 2009-08-04T02:11:08Z

[Term]
id: GO:0044145
name: modulation of formation of structure involved in a symbiotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph]
synonym: "modulation of development of symbiont involved in interaction with host" RELATED []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044111 ! regulates formation of structure involved in a symbiotic process
relationship: RO:0002211 GO:0044111 ! regulates formation of structure involved in a symbiotic process
created_by: jl
creation_date: 2009-08-06T01:57:38Z

[Term]
id: GO:0044207
name: translation initiation ternary complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl]
synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW []
synonym: "translation initiation (ternary) complex" EXACT []
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm
created_by: jl
creation_date: 2009-10-22T02:38:55Z

[Term]
id: GO:0044217
name: other organism part
namespace: cellular_component
def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0110165 ! cellular anatomical structure
created_by: jl
creation_date: 2009-11-12T01:18:21Z

[Term]
id: GO:0044237
name: obsolete cellular metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
comment: The reason for obsoletion is that this term is now redundant with GO:0008152, metabolic process
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
xref: Reactome:R-HSA-1428517 "Aerobic respiration and respiratory electron transport"

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_pir
subset: goslim_plant_ribbon
subset: goslim_prokaryote_ribbon
synonym: "primary metabolism" EXACT []
xref: Wikipedia:Primary_metabolite
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044281
name: small molecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "small molecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2010-01-26T12:05:20Z

[Term]
id: GO:0044282
name: small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
synonym: "small molecule catabolism" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044281 ! small molecule metabolic process
creation_date: 2010-01-26T12:06:10Z

[Term]
id: GO:0044283
name: small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "small molecule biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044281 ! small molecule metabolic process
created_by: jl
creation_date: 2010-01-26T12:06:49Z

[Term]
id: GO:0044292
name: dendrite terminus
namespace: cellular_component
def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134]
synonym: "dendrite terminal" EXACT []
synonym: "dendrite terminal specialization" RELATED []
synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134]
synonym: "terminal specialization of a dendrite" EXACT []
xref: NIF_Subcellular:sao28175134
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0030425 ! part of dendrite
creation_date: 2010-02-04T03:14:37Z

[Term]
id: GO:0044293
name: dendriole
namespace: cellular_component
def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904]
xref: NIF_Subcellular:sao28175134
xref: NIF_Subcellular:sao295057932
is_a: GO:0044292 ! dendrite terminus
creation_date: 2010-02-04T03:32:02Z

[Term]
id: GO:0044297
name: cell body
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
synonym: "cell soma" EXACT []
xref: FBbt:00005107
xref: FMA:67301
xref: Wikipedia:Cell_body
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell
creation_date: 2010-02-05T10:37:16Z

[Term]
id: GO:0044346
name: fibroblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]
synonym: "fibroblast apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000057 ! occurs in fibroblast
relationship: BFO:0000066 CL:0000057 ! occurs in fibroblast
creation_date: 2010-09-23T11:33:38Z

[Term]
id: GO:0044380
name: protein localization to cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]
synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005856 ! has target end location cytoskeleton
relationship: RO:0002339 GO:0005856 ! has target end location cytoskeleton
creation_date: 2011-12-13T11:43:24Z

[Term]
id: GO:0044403
name: biological process involved in symbiotic interaction
namespace: biological_process
alt_id: GO:0043298
alt_id: GO:0044404
alt_id: GO:0072519
alt_id: GO:0085031
def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, PMID:31257129]
subset: goslim_chembl
synonym: "commensalism" NARROW []
synonym: "host-pathogen interaction" NARROW []
synonym: "parasitism" NARROW []
synonym: "symbiosis" RELATED []
synonym: "symbiosis, encompassing mutualism through parasitism" RELATED []
synonym: "symbiotic interaction" RELATED []
synonym: "symbiotic interaction between host and organism" RELATED []
synonym: "symbiotic interaction between organisms" RELATED []
synonym: "symbiotic interaction between species" RELATED []
synonym: "symbiotic process" RELATED []
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044409
name: entry into host
namespace: biological_process
alt_id: GO:0030260
alt_id: GO:0044411
alt_id: GO:0051806
alt_id: GO:0051828
alt_id: GO:0051830
alt_id: GO:0075052
alt_id: GO:0085027
alt_id: GO:0085028
def: "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:vw]
subset: goslim_virus
synonym: "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb]
synonym: "entry into cell of other organism involved in symbiotic interaction" RELATED []
synonym: "entry into host" EXACT []
synonym: "entry into host cell via penetration peg" NARROW []
synonym: "entry into host through host barriers" RELATED []
synonym: "entry into host via a specialized structure during symbiotic interaction" NARROW []
synonym: "entry into host via enzymatic degradation of host anatomical structure" NARROW []
synonym: "entry into host via enzymatic degradation of host cuticle" NARROW []
synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "entry into other organism involved in symbiotic interaction" RELATED []
synonym: "host invasion" EXACT []
synonym: "host penetration" EXACT [GOC:vw]
synonym: "invasion into host" EXACT []
synonym: "invasion into other organism" RELATED []
synonym: "invasion of host" EXACT []
synonym: "invasion of other organism" RELATED []
synonym: "invasive growth" RELATED []
synonym: "other organism invasion" RELATED []
synonym: "penetration into host" EXACT [GOC:vw]
synonym: "penetration into host via a specialized structure" NARROW [GOC:vw]
synonym: "penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw]
xref: Reactome:R-HSA-173107 "Binding and entry of HIV virion"
is_a: GO:0051701 ! biological process involved in interaction with host

[Term]
id: GO:0044419
name: biological process involved in interspecies interaction between organisms
namespace: biological_process
def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction between organisms" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
xref: Reactome:R-HSA-9824443 "Parasitic Infection Pathways"
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044423
name: virion component
namespace: cellular_component
def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
synonym: "complete virus particle" RELATED []
synonym: "virion" RELATED []
synonym: "virion part" EXACT []
xref: Wikipedia:Virus
is_a: GO:0005575 ! cellular_component
disjoint_from: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0044458
name: motile cilium assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]
synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "motile primary cilium assembly" RELATED []
synonym: "motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0060271 ! cilium assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0031514 ! results in assembly of motile cilium
relationship: RO:0002588 GO:0031514 ! results in assembly of motile cilium
creation_date: 2015-02-06T17:23:23Z

[Term]
id: GO:0044464
name: obsolete cell part
namespace: cellular_component
def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602]
synonym: "protoplast" RELATED [GOC:mah]

[Term]
id: GO:0044550
name: secondary metabolite biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
subset: goslim_prokaryote
synonym: "secondary metabolite biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0019748 ! secondary metabolic process
created_by: jl
creation_date: 2012-03-29T01:55:18Z

[Term]
id: GO:0044565
name: dendritic cell proliferation
namespace: biological_process
def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816]
is_a: GO:0032943 ! mononuclear cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000451 ! acts on population of dendritic cell
relationship: RO:0012003 CL:0000451 ! acts on population of dendritic cell
creation_date: 2012-04-05T04:31:39Z

[Term]
id: GO:0044566
name: chondrocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000138 ! has primary input chondrocyte
relationship: RO:0004009 CL:0000138 ! has primary input chondrocyte
creation_date: 2012-04-05T04:45:38Z

[Term]
id: GO:0044703
name: multi-organism reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
is_a: GO:0022414 ! reproductive process
creation_date: 2012-09-19T15:56:30Z

[Term]
id: GO:0044706
name: multi-multicellular organism process
namespace: biological_process
def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl]
is_a: GO:0032501 ! multicellular organismal process
creation_date: 2012-09-19T16:06:16Z

[Term]
id: GO:0044743
name: protein transmembrane import into intracellular organelle
namespace: biological_process
def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]
is_a: GO:0065002 ! intracellular protein transmembrane transport
is_a: GO:0072594 ! establishment of protein localization to organelle
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0043229 ! has target end location intracellular organelle
intersection_of: RO:0002342 GO:0031090 ! results in transport across organelle membrane
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0043229 ! has target end location intracellular organelle
relationship: RO:0002342 GO:0031090 ! results in transport across organelle membrane
creation_date: 2012-11-07T15:37:36Z

[Term]
id: GO:0044782
name: cilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
subset: goslim_drosophila
subset: goslim_generic
synonym: "microtubule-based flagellum organization" EXACT []
is_a: GO:0006996 ! organelle organization
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005929 ! results in organization of cilium
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
relationship: RO:0002592 GO:0005929 ! results in organization of cilium
creation_date: 2013-03-27T15:09:58Z

[Term]
id: GO:0044848
name: biological phase
namespace: biological_process
def: "A distinct period or stage in a biological process or cycle." [GOC:jl]
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.
subset: gocheck_do_not_annotate
is_a: GO:0008150 ! biological_process
disjoint_from: GO:0050896 ! response to stimulus
disjoint_from: GO:0051179 ! localization
disjoint_from: GO:0071840 ! cellular component organization or biogenesis
created_by: jl
creation_date: 2014-07-16T13:12:40Z

[Term]
id: GO:0044877
name: protein-containing complex binding
namespace: molecular_function
alt_id: GO:0032403
def: "Binding to a macromolecular complex." [GOC:jl]
subset: goslim_chembl
synonym: "macromolecular complex binding" RELATED []
synonym: "protein complex binding" EXACT []
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex
relationship: RO:0004009 GO:0032991 ! has primary input protein-containing complex
created_by: jl
creation_date: 2014-12-16T11:38:58Z

[Term]
id: GO:0045026
name: plasma membrane fusion
namespace: biological_process
def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" BROAD []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0061025 ! membrane fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0005886 ! results in fusion of plasma membrane
relationship: RO:0012008 GO:0005886 ! results in fusion of plasma membrane

[Term]
id: GO:0045037
name: protein import into chloroplast stroma
namespace: biological_process
def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363]
synonym: "chloroplast stroma protein import" EXACT []
synonym: "protein transport into chloroplast stroma" EXACT []
is_a: GO:0071806 ! protein transmembrane transport
is_a: GO:0072596 ! establishment of protein localization to chloroplast
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0002339 GO:0009570 ! has target end location chloroplast stroma
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0002339 GO:0009570 ! has target end location chloroplast stroma

[Term]
id: GO:0045087
name: innate immune response
namespace: biological_process
alt_id: GO:0002226
def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
synonym: "innate immunity" EXACT [GOC:pg]
synonym: "nonspecific immune response" EXACT []
xref: Reactome:R-HSA-168249 "Innate Immune System"
xref: Wikipedia:Innate_immune_system
is_a: GO:0006955 ! immune response
is_a: GO:0140546 ! defense response to symbiont

[Term]
id: GO:0045088
name: regulation of innate immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045087 ! regulates innate immune response
relationship: RO:0002211 GO:0045087 ! regulates innate immune response

[Term]
id: GO:0045089
name: positive regulation of innate immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
synonym: "stimulation of innate immune response" NARROW []
synonym: "up regulation of innate immune response" EXACT []
synonym: "up-regulation of innate immune response" EXACT []
synonym: "upregulation of innate immune response" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045087 ! positively regulates innate immune response
relationship: RO:0002213 GO:0045087 ! positively regulates innate immune response

[Term]
id: GO:0045124
name: regulation of bone resorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai]
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045453 ! regulates bone resorption
relationship: RO:0002211 GO:0045453 ! regulates bone resorption

[Term]
id: GO:0045132
name: meiotic chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
is_a: GO:0098813 ! nuclear chromosome segregation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: BFO:0000050 GO:0140013 ! part of meiotic nuclear division
relationship: BFO:0000050 GO:0140013 ! part of meiotic nuclear division

[Term]
id: GO:0045137
name: development of primary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development
relationship: BFO:0000050 GO:0007548 ! part of sex differentiation

[Term]
id: GO:0045144
name: meiotic sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
synonym: "meiosis II, chromosome segregation" EXACT []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:0045132 ! meiotic chromosome segregation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0000819 ! sister chromatid segregation
intersection_of: BFO:0000050 GO:0007135 ! part of meiosis II
relationship: BFO:0000050 GO:0007135 ! part of meiosis II

[Term]
id: GO:0045165
name: cell fate commitment
namespace: biological_process
def: "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]
comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
is_a: GO:0048869 ! cellular developmental process
relationship: BFO:0000050 GO:0030154 ! part of cell differentiation

[Term]
id: GO:0045168
name: cell-cell signaling involved in cell fate commitment
namespace: biological_process
def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell fate commitment, cell-cell signaling" EXACT []
synonym: "cell fate commitment, cell-cell signalling" EXACT []
synonym: "cell-cell signaling during in cell fate commitment" EXACT []
synonym: "cell-cell signaling resulting in cell fate commitment" EXACT []
synonym: "cell-cell signalling during cell fate commitment" EXACT []
synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb]
synonym: "cell-cell signalling resulting in cell fate commitment" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: BFO:0000050 GO:0045165 ! part of cell fate commitment
relationship: BFO:0000050 GO:0045165 ! part of cell fate commitment

[Term]
id: GO:0045177
name: apical part of cell
namespace: cellular_component
def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "apical region of cell" EXACT [GOC:krc]
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell

[Term]
id: GO:0045179
name: apical cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: BFO:0000050 GO:0045177 ! part of apical part of cell
relationship: BFO:0000050 GO:0045177 ! part of apical part of cell

[Term]
id: GO:0045184
name: establishment of protein localization
namespace: biological_process
def: "The directed movement of a protein to a specific location." [GOC:bf]
synonym: "establishment of protein localisation" EXACT [GOC:mah]
synonym: "protein positioning" EXACT []
synonym: "protein recruitment" EXACT []
is_a: GO:0008104 ! intracellular protein localization
is_a: GO:0051234 ! establishment of localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: RO:0004009 CHEBI:36080 ! has primary input protein

[Term]
id: GO:0045185
name: maintenance of protein location
namespace: biological_process
def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
synonym: "active protein retrieval" NARROW []
synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb]
synonym: "protein retention" NARROW []
synonym: "protein sequestering" NARROW []
is_a: GO:0051235 ! maintenance of location
relationship: BFO:0000050 GO:0008104 ! part of intracellular protein localization

[Term]
id: GO:0045196
name: establishment or maintenance of neuroblast polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: BFO:0000050 GO:0055059 ! part of asymmetric neuroblast division

[Term]
id: GO:0045200
name: establishment of neuroblast polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "establishment of neuroblast cell polarity" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata)
relationship: BFO:0000066 CL:0000031 ! occurs in neuroblast (sensu Vertebrata)

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_synapse
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497]
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse
is_a: GO:0030054 ! cell junction
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_synapse
synonym: "post-synaptic membrane" EXACT []
is_a: GO:0097060 ! synaptic membrane
relationship: BFO:0000050 GO:0098794 ! part of postsynapse

[Term]
id: GO:0045214
name: sarcomere organization
namespace: biological_process
def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
synonym: "sarcomere alignment" EXACT []
synonym: "sarcomere organisation" EXACT []
is_a: GO:0031032 ! actomyosin structure organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0030017 ! results in organization of sarcomere
relationship: BFO:0000050 GO:0030239 ! part of myofibril assembly
relationship: RO:0002592 GO:0030017 ! results in organization of sarcomere

[Term]
id: GO:0045216
name: cell-cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "cell-cell junction assembly and maintenance" EXACT []
synonym: "cell-cell junction biogenesis" RELATED []
synonym: "cell-cell junction organisation" EXACT [GOC:mah]
synonym: "intercellular junction assembly and maintenance" EXACT []
xref: Reactome:R-HSA-421270 "Cell-cell junction organization"
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0034330 ! cell junction organization
intersection_of: RO:0002592 GO:0005911 ! results in organization of cell-cell junction
relationship: RO:0002592 GO:0005911 ! results in organization of cell-cell junction

[Term]
id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "external encapsulating structure organisation" EXACT []
synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure
relationship: RO:0002592 GO:0030312 ! results in organization of external encapsulating structure

[Term]
id: GO:0045296
name: cadherin binding
namespace: molecular_function
def: "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]
is_a: GO:0050839 ! cell adhesion molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000001327 ! has primary input cadherin
relationship: RO:0004009 PR:000001327 ! has primary input cadherin

[Term]
id: GO:0045321
name: leukocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]
synonym: "immune cell activation" EXACT []
synonym: "leucocyte activation" EXACT []
xref: Wikipedia:Immunologic_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0002376 ! immune system process
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000738 ! has primary input leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0004009 CL:0000738 ! has primary input leukocyte

[Term]
id: GO:0045444
name: fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators]
synonym: "adipocyte cell differentiation" EXACT []
synonym: "adipocyte differentiation" EXACT []
synonym: "adipogenesis" RELATED []
synonym: "adipose cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte
relationship: RO:0002315 CL:0000136 ! results in acquisition of features of adipocyte

[Term]
id: GO:0045445
name: myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "myoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast
relationship: BFO:0000050 GO:0061061 ! part of muscle structure development
relationship: RO:0002315 CL:0000056 ! results in acquisition of features of myoblast

[Term]
id: GO:0045446
name: endothelial cell differentiation
namespace: biological_process
def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell
relationship: BFO:0000050 GO:0003158 ! part of endothelium development
relationship: RO:0002315 CL:0000115 ! results in acquisition of features of endothelial cell

[Term]
id: GO:0045453
name: bone resorption
namespace: biological_process
def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780]
xref: Wikipedia:Bone_resorption
is_a: GO:0001894 ! tissue homeostasis
relationship: BFO:0000050 GO:0046849 ! part of bone remodeling

[Term]
id: GO:0045580
name: regulation of T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T cell development" RELATED [GOC:add]
synonym: "regulation of T lymphocyte differentiation" EXACT []
synonym: "regulation of T-cell differentiation" EXACT []
synonym: "regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030217 ! regulates T cell differentiation
relationship: RO:0002211 GO:0030217 ! regulates T cell differentiation

[Term]
id: GO:0045581
name: negative regulation of T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T cell differentiation" EXACT []
synonym: "down-regulation of T cell differentiation" EXACT []
synonym: "downregulation of T cell differentiation" EXACT []
synonym: "inhibition of T cell differentiation" NARROW []
synonym: "negative regulation of T cell development" RELATED [GOC:add]
synonym: "negative regulation of T lymphocyte differentiation" EXACT []
synonym: "negative regulation of T-cell differentiation" EXACT []
synonym: "negative regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030217 ! negatively regulates T cell differentiation
relationship: RO:0002212 GO:0030217 ! negatively regulates T cell differentiation

[Term]
id: GO:0045582
name: positive regulation of T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T cell differentiation" NARROW []
synonym: "positive regulation of T cell development" RELATED [GOC:add]
synonym: "positive regulation of T lymphocyte differentiation" EXACT []
synonym: "positive regulation of T-cell differentiation" EXACT []
synonym: "positive regulation of T-lymphocyte differentiation" EXACT []
synonym: "stimulation of T cell differentiation" NARROW []
synonym: "up regulation of T cell differentiation" EXACT []
synonym: "up-regulation of T cell differentiation" EXACT []
synonym: "upregulation of T cell differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030217 ! positively regulates T cell differentiation
relationship: RO:0002213 GO:0030217 ! positively regulates T cell differentiation

[Term]
id: GO:0045595
name: regulation of cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030154 ! regulates cell differentiation
relationship: RO:0002211 GO:0030154 ! regulates cell differentiation

[Term]
id: GO:0045596
name: negative regulation of cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
synonym: "down regulation of cell differentiation" EXACT []
synonym: "down-regulation of cell differentiation" EXACT []
synonym: "downregulation of cell differentiation" EXACT []
synonym: "inhibition of cell differentiation" NARROW []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030154 ! negatively regulates cell differentiation
relationship: RO:0002212 GO:0030154 ! negatively regulates cell differentiation

[Term]
id: GO:0045597
name: positive regulation of cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]
synonym: "activation of cell differentiation" NARROW []
synonym: "stimulation of cell differentiation" NARROW []
synonym: "up regulation of cell differentiation" EXACT []
synonym: "up-regulation of cell differentiation" EXACT []
synonym: "upregulation of cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030154 ! positively regulates cell differentiation
relationship: RO:0002213 GO:0030154 ! positively regulates cell differentiation

[Term]
id: GO:0045598
name: regulation of fat cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "regulation of adipocyte cell differentiation" EXACT []
synonym: "regulation of adipocyte differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045444 ! regulates fat cell differentiation
relationship: RO:0002211 GO:0045444 ! regulates fat cell differentiation

[Term]
id: GO:0045599
name: negative regulation of fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "down regulation of fat cell differentiation" EXACT []
synonym: "down-regulation of fat cell differentiation" EXACT []
synonym: "downregulation of fat cell differentiation" EXACT []
synonym: "inhibition of fat cell differentiation" NARROW []
synonym: "negative regulation of adipocyte cell differentiation" EXACT []
synonym: "negative regulation of adipocyte differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation
relationship: RO:0002212 GO:0045444 ! negatively regulates fat cell differentiation

[Term]
id: GO:0045600
name: positive regulation of fat cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "activation of fat cell differentiation" NARROW []
synonym: "positive regulation of adipocyte cell differentiation" EXACT []
synonym: "positive regulation of adipocyte differentiation" EXACT []
synonym: "stimulation of fat cell differentiation" NARROW []
synonym: "up regulation of fat cell differentiation" EXACT []
synonym: "up-regulation of fat cell differentiation" EXACT []
synonym: "upregulation of fat cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation
relationship: RO:0002213 GO:0045444 ! positively regulates fat cell differentiation

[Term]
id: GO:0045601
name: regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation
relationship: RO:0002211 GO:0045446 ! regulates endothelial cell differentiation

[Term]
id: GO:0045602
name: negative regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "down regulation of endothelial cell differentiation" EXACT []
synonym: "down-regulation of endothelial cell differentiation" EXACT []
synonym: "downregulation of endothelial cell differentiation" EXACT []
synonym: "inhibition of endothelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation
relationship: RO:0002212 GO:0045446 ! negatively regulates endothelial cell differentiation

[Term]
id: GO:0045603
name: positive regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "activation of endothelial cell differentiation" NARROW []
synonym: "stimulation of endothelial cell differentiation" NARROW []
synonym: "up regulation of endothelial cell differentiation" EXACT []
synonym: "up-regulation of endothelial cell differentiation" EXACT []
synonym: "upregulation of endothelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation
relationship: RO:0002213 GO:0045446 ! positively regulates endothelial cell differentiation

[Term]
id: GO:0045604
name: regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045682 ! regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation
relationship: RO:0002211 GO:0009913 ! regulates epidermal cell differentiation

[Term]
id: GO:0045605
name: negative regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "down regulation of epidermal cell differentiation" EXACT []
synonym: "down-regulation of epidermal cell differentiation" EXACT []
synonym: "downregulation of epidermal cell differentiation" EXACT []
synonym: "inhibition of epidermal cell differentiation" NARROW []
synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045683 ! negative regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation
relationship: RO:0002212 GO:0009913 ! negatively regulates epidermal cell differentiation

[Term]
id: GO:0045606
name: positive regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "activation of epidermal cell differentiation" NARROW []
synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermal cell differentiation" NARROW []
synonym: "up regulation of epidermal cell differentiation" EXACT []
synonym: "up-regulation of epidermal cell differentiation" EXACT []
synonym: "upregulation of epidermal cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045684 ! positive regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation
relationship: RO:0002213 GO:0009913 ! positively regulates epidermal cell differentiation

[Term]
id: GO:0045619
name: regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030098 ! regulates lymphocyte differentiation
relationship: RO:0002211 GO:0030098 ! regulates lymphocyte differentiation

[Term]
id: GO:0045620
name: negative regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of lymphocyte differentiation" EXACT []
synonym: "down-regulation of lymphocyte differentiation" EXACT []
synonym: "downregulation of lymphocyte differentiation" EXACT []
synonym: "inhibition of lymphocyte differentiation" NARROW []
synonym: "negative regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030098 ! negatively regulates lymphocyte differentiation
relationship: RO:0002212 GO:0030098 ! negatively regulates lymphocyte differentiation

[Term]
id: GO:0045621
name: positive regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of lymphocyte differentiation" NARROW []
synonym: "positive regulation of lymphocyte development" RELATED [GOC:add]
synonym: "stimulation of lymphocyte differentiation" NARROW []
synonym: "up regulation of lymphocyte differentiation" EXACT []
synonym: "up-regulation of lymphocyte differentiation" EXACT []
synonym: "upregulation of lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030098 ! positively regulates lymphocyte differentiation
relationship: RO:0002213 GO:0030098 ! positively regulates lymphocyte differentiation

[Term]
id: GO:0045637
name: regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
xref: Reactome:R-HSA-8939246 "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation
relationship: RO:0002211 GO:0030099 ! regulates myeloid cell differentiation

[Term]
id: GO:0045638
name: negative regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "down regulation of myeloid cell differentiation" EXACT []
synonym: "down-regulation of myeloid cell differentiation" EXACT []
synonym: "downregulation of myeloid cell differentiation" EXACT []
synonym: "inhibition of myeloid cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation
relationship: RO:0002212 GO:0030099 ! negatively regulates myeloid cell differentiation

[Term]
id: GO:0045639
name: positive regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "activation of myeloid cell differentiation" NARROW []
synonym: "stimulation of myeloid cell differentiation" NARROW []
synonym: "up regulation of myeloid cell differentiation" EXACT []
synonym: "up-regulation of myeloid cell differentiation" EXACT []
synonym: "upregulation of myeloid cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation
relationship: RO:0002213 GO:0030099 ! positively regulates myeloid cell differentiation

[Term]
id: GO:0045646
name: regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation
relationship: RO:0002211 GO:0030218 ! regulates erythrocyte differentiation

[Term]
id: GO:0045647
name: negative regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "down regulation of erythrocyte differentiation" EXACT []
synonym: "down-regulation of erythrocyte differentiation" EXACT []
synonym: "downregulation of erythrocyte differentiation" EXACT []
synonym: "inhibition of erythrocyte differentiation" NARROW []
synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation
relationship: RO:0002212 GO:0030218 ! negatively regulates erythrocyte differentiation

[Term]
id: GO:0045648
name: positive regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "activation of erythrocyte differentiation" NARROW []
synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232]
synonym: "stimulation of erythrocyte differentiation" NARROW []
synonym: "up regulation of erythrocyte differentiation" EXACT []
synonym: "up-regulation of erythrocyte differentiation" EXACT []
synonym: "upregulation of erythrocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation
relationship: RO:0002213 GO:0030218 ! positively regulates erythrocyte differentiation

[Term]
id: GO:0045649
name: regulation of macrophage differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030225 ! regulates macrophage differentiation
relationship: RO:0002211 GO:0030225 ! regulates macrophage differentiation

[Term]
id: GO:0045650
name: negative regulation of macrophage differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "down regulation of macrophage differentiation" EXACT []
synonym: "down-regulation of macrophage differentiation" EXACT []
synonym: "downregulation of macrophage differentiation" EXACT []
synonym: "inhibition of macrophage differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030225 ! negatively regulates macrophage differentiation
relationship: RO:0002212 GO:0030225 ! negatively regulates macrophage differentiation

[Term]
id: GO:0045651
name: positive regulation of macrophage differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "activation of macrophage differentiation" NARROW []
synonym: "stimulation of macrophage differentiation" NARROW []
synonym: "up regulation of macrophage differentiation" EXACT []
synonym: "up-regulation of macrophage differentiation" EXACT []
synonym: "upregulation of macrophage differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030225 ! positively regulates macrophage differentiation
relationship: RO:0002213 GO:0030225 ! positively regulates macrophage differentiation

[Term]
id: GO:0045652
name: regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
xref: Reactome:R-HSA-8936459 "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation
relationship: RO:0002211 GO:0030219 ! regulates megakaryocyte differentiation

[Term]
id: GO:0045653
name: negative regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "down regulation of megakaryocyte differentiation" EXACT []
synonym: "down-regulation of megakaryocyte differentiation" EXACT []
synonym: "downregulation of megakaryocyte differentiation" EXACT []
synonym: "inhibition of megakaryocyte differentiation" NARROW []
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation
relationship: RO:0002212 GO:0030219 ! negatively regulates megakaryocyte differentiation

[Term]
id: GO:0045654
name: positive regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "activation of megakaryocyte differentiation" NARROW []
synonym: "stimulation of megakaryocyte differentiation" NARROW []
synonym: "up regulation of megakaryocyte differentiation" EXACT []
synonym: "up-regulation of megakaryocyte differentiation" EXACT []
synonym: "upregulation of megakaryocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation
relationship: RO:0002213 GO:0030219 ! positively regulates megakaryocyte differentiation

[Term]
id: GO:0045655
name: regulation of monocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030224 ! regulates monocyte differentiation
relationship: RO:0002211 GO:0030224 ! regulates monocyte differentiation

[Term]
id: GO:0045656
name: negative regulation of monocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "down regulation of monocyte differentiation" EXACT []
synonym: "down-regulation of monocyte differentiation" EXACT []
synonym: "downregulation of monocyte differentiation" EXACT []
synonym: "inhibition of monocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030224 ! negatively regulates monocyte differentiation
relationship: RO:0002212 GO:0030224 ! negatively regulates monocyte differentiation

[Term]
id: GO:0045657
name: positive regulation of monocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "activation of monocyte differentiation" NARROW []
synonym: "stimulation of monocyte differentiation" NARROW []
synonym: "up regulation of monocyte differentiation" EXACT []
synonym: "up-regulation of monocyte differentiation" EXACT []
synonym: "upregulation of monocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030224 ! positively regulates monocyte differentiation
relationship: RO:0002213 GO:0030224 ! positively regulates monocyte differentiation

[Term]
id: GO:0045661
name: regulation of myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045445 ! regulates myoblast differentiation
relationship: RO:0002211 GO:0045445 ! regulates myoblast differentiation

[Term]
id: GO:0045662
name: negative regulation of myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "down regulation of myoblast differentiation" EXACT []
synonym: "down-regulation of myoblast differentiation" EXACT []
synonym: "downregulation of myoblast differentiation" EXACT []
synonym: "inhibition of myoblast differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045661 ! regulation of myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation
relationship: RO:0002212 GO:0045445 ! negatively regulates myoblast differentiation

[Term]
id: GO:0045663
name: positive regulation of myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "activation of myoblast differentiation" NARROW []
synonym: "stimulation of myoblast differentiation" NARROW []
synonym: "up regulation of myoblast differentiation" EXACT []
synonym: "up-regulation of myoblast differentiation" EXACT []
synonym: "upregulation of myoblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045661 ! regulation of myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation
relationship: RO:0002213 GO:0045445 ! positively regulates myoblast differentiation

[Term]
id: GO:0045664
name: regulation of neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030182 ! regulates neuron differentiation
relationship: RO:0002211 GO:0030182 ! regulates neuron differentiation

[Term]
id: GO:0045665
name: negative regulation of neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "down regulation of neuron differentiation" EXACT []
synonym: "down-regulation of neuron differentiation" EXACT []
synonym: "downregulation of neuron differentiation" EXACT []
synonym: "inhibition of neuron differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation
relationship: RO:0002212 GO:0030182 ! negatively regulates neuron differentiation

[Term]
id: GO:0045666
name: positive regulation of neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "activation of neuron differentiation" NARROW []
synonym: "stimulation of neuron differentiation" NARROW []
synonym: "up regulation of neuron differentiation" EXACT []
synonym: "up-regulation of neuron differentiation" EXACT []
synonym: "upregulation of neuron differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030182 ! positively regulates neuron differentiation
relationship: RO:0002213 GO:0030182 ! positively regulates neuron differentiation

[Term]
id: GO:0045670
name: regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030316 ! regulates osteoclast differentiation
relationship: RO:0002211 GO:0030316 ! regulates osteoclast differentiation

[Term]
id: GO:0045671
name: negative regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoclast differentiation" EXACT []
synonym: "down-regulation of osteoclast differentiation" EXACT []
synonym: "downregulation of osteoclast differentiation" EXACT []
synonym: "inhibition of osteoclast differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030316 ! negatively regulates osteoclast differentiation
relationship: RO:0002212 GO:0030316 ! negatively regulates osteoclast differentiation

[Term]
id: GO:0045672
name: positive regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "activation of osteoclast differentiation" NARROW []
synonym: "stimulation of osteoclast differentiation" NARROW []
synonym: "up regulation of osteoclast differentiation" EXACT []
synonym: "up-regulation of osteoclast differentiation" EXACT []
synonym: "upregulation of osteoclast differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030316 ! positively regulates osteoclast differentiation
relationship: RO:0002213 GO:0030316 ! positively regulates osteoclast differentiation

[Term]
id: GO:0045682
name: regulation of epidermis development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "regulation of epidermal development" EXACT []
synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008544 ! regulates epidermis development
relationship: RO:0002211 GO:0008544 ! regulates epidermis development

[Term]
id: GO:0045683
name: negative regulation of epidermis development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "down regulation of epidermis development" EXACT []
synonym: "down-regulation of epidermis development" EXACT []
synonym: "downregulation of epidermis development" EXACT []
synonym: "inhibition of epidermis development" NARROW []
synonym: "negative regulation of epidermal development" EXACT []
synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008544 ! negatively regulates epidermis development
relationship: RO:0002212 GO:0008544 ! negatively regulates epidermis development

[Term]
id: GO:0045684
name: positive regulation of epidermis development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "activation of epidermis development" NARROW []
synonym: "positive regulation of epidermal development" EXACT []
synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermis development" NARROW []
synonym: "up regulation of epidermis development" EXACT []
synonym: "up-regulation of epidermis development" EXACT []
synonym: "upregulation of epidermis development" EXACT []
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008544 ! positively regulates epidermis development
relationship: RO:0002213 GO:0008544 ! positively regulates epidermis development

[Term]
id: GO:0045685
name: regulation of glial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "regulation of glia cell differentiation" EXACT []
synonym: "regulation of neuroglia differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010001 ! regulates glial cell differentiation
relationship: RO:0002211 GO:0010001 ! regulates glial cell differentiation

[Term]
id: GO:0045686
name: negative regulation of glial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "down regulation of glial cell differentiation" EXACT []
synonym: "down-regulation of glial cell differentiation" EXACT []
synonym: "downregulation of glial cell differentiation" EXACT []
synonym: "inhibition of glial cell differentiation" NARROW []
synonym: "negative regulation of glia cell differentiation" EXACT []
synonym: "negative regulation of neuroglia differentiation" EXACT []
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation
relationship: RO:0002212 GO:0010001 ! negatively regulates glial cell differentiation

[Term]
id: GO:0045687
name: positive regulation of glial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "activation of glial cell differentiation" NARROW []
synonym: "positive regulation of glia cell differentiation" EXACT []
synonym: "positive regulation of neuroglia differentiation" EXACT []
synonym: "stimulation of glial cell differentiation" NARROW []
synonym: "up regulation of glial cell differentiation" EXACT []
synonym: "up-regulation of glial cell differentiation" EXACT []
synonym: "upregulation of glial cell differentiation" EXACT []
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation
relationship: RO:0002213 GO:0010001 ! positively regulates glial cell differentiation

[Term]
id: GO:0045724
name: positive regulation of cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]
synonym: "activation of cilium assembly" NARROW []
synonym: "positive regulation of flagellum assembly" BROAD []
synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cilium assembly" NARROW []
synonym: "up regulation of cilium assembly" EXACT []
synonym: "up-regulation of cilium assembly" EXACT []
synonym: "upregulation of cilium assembly" EXACT []
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060271 ! positively regulates cilium assembly
relationship: RO:0002213 GO:0060271 ! positively regulates cilium assembly

[Term]
id: GO:0045727
name: positive regulation of translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of protein biosynthetic process" NARROW []
synonym: "positive regulation of protein anabolism" EXACT []
synonym: "positive regulation of protein biosynthesis" EXACT []
synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb]
synonym: "positive regulation of protein formation" EXACT []
synonym: "positive regulation of protein synthesis" EXACT []
synonym: "stimulation of protein biosynthetic process" NARROW []
synonym: "up regulation of protein biosynthetic process" EXACT []
synonym: "up-regulation of protein biosynthetic process" EXACT []
synonym: "upregulation of protein biosynthetic process" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006412 ! positively regulates translation
relationship: RO:0002213 GO:0006412 ! positively regulates translation

[Term]
id: GO:0045730
name: respiratory burst
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732]
synonym: "metabolic burst" EXACT []
synonym: "oxidative burst" EXACT []
xref: Wikipedia:Respiratory_burst
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0045732
name: positive regulation of protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of protein catabolic process" NARROW []
synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolic process" EXACT []
synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol]
synonym: "positive regulation of cyclin catabolic process" NARROW []
synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol]
synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol]
synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol]
synonym: "positive regulation of protein breakdown" EXACT []
synonym: "positive regulation of protein catabolism" EXACT []
synonym: "positive regulation of protein degradation" EXACT []
synonym: "stimulation of protein catabolic process" NARROW []
synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein catabolic process" EXACT []
synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process" EXACT []
synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030163 ! positively regulates protein catabolic process
relationship: RO:0002213 GO:0030163 ! positively regulates protein catabolic process

[Term]
id: GO:0045744
name: negative regulation of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]
synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of GPCR protein signaling pathway" EXACT []
synonym: "negative regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007186 ! negatively regulates G protein-coupled receptor signaling pathway
relationship: RO:0002212 GO:0007186 ! negatively regulates G protein-coupled receptor signaling pathway

[Term]
id: GO:0045745
name: positive regulation of G protein-coupled receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of GPCR protein signaling pathway" EXACT []
synonym: "positive regulation of GPCR protein signalling pathway" EXACT []
synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007186 ! positively regulates G protein-coupled receptor signaling pathway
relationship: RO:0002213 GO:0007186 ! positively regulates G protein-coupled receptor signaling pathway

[Term]
id: GO:0045759
name: negative regulation of action potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "down regulation of action potential" EXACT []
synonym: "down-regulation of action potential" EXACT []
synonym: "downregulation of action potential" EXACT []
synonym: "inhibition of action potential" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001508 ! negatively regulates action potential
relationship: RO:0002212 GO:0001508 ! negatively regulates action potential

[Term]
id: GO:0045760
name: positive regulation of action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "activation of action potential" NARROW []
synonym: "stimulation of action potential" NARROW []
synonym: "up regulation of action potential" EXACT []
synonym: "up-regulation of action potential" EXACT []
synonym: "upregulation of action potential" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001508 ! positively regulates action potential
relationship: RO:0002213 GO:0001508 ! positively regulates action potential

[Term]
id: GO:0045763
name: negative regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
synonym: "down regulation of amino acid metabolic process" EXACT []
synonym: "down-regulation of amino acid metabolic process" EXACT []
synonym: "downregulation of amino acid metabolic process" EXACT []
synonym: "inhibition of amino acid metabolic process" NARROW []
synonym: "negative regulation of amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process
relationship: RO:0002212 GO:0006520 ! negatively regulates amino acid metabolic process

[Term]
id: GO:0045764
name: positive regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
synonym: "activation of amino acid metabolic process" NARROW []
synonym: "positive regulation of amino acid metabolism" EXACT []
synonym: "positive regulation of cellular amino acid metabolic process" EXACT []
synonym: "stimulation of amino acid metabolic process" NARROW []
synonym: "up regulation of amino acid metabolic process" EXACT []
synonym: "up-regulation of amino acid metabolic process" EXACT []
synonym: "upregulation of amino acid metabolic process" EXACT []
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process
relationship: RO:0002213 GO:0006520 ! positively regulates amino acid metabolic process

[Term]
id: GO:0045765
name: regulation of angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001525 ! regulates angiogenesis
relationship: RO:0002211 GO:0001525 ! regulates angiogenesis

[Term]
id: GO:0045766
name: positive regulation of angiogenesis
namespace: biological_process
def: "Any process that activates or increases angiogenesis." [GOC:go_curators]
synonym: "activation of angiogenesis" NARROW []
synonym: "stimulation of angiogenesis" NARROW []
synonym: "up regulation of angiogenesis" EXACT []
synonym: "up-regulation of angiogenesis" EXACT []
synonym: "upregulation of angiogenesis" EXACT []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:1904018 ! positive regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001525 ! positively regulates angiogenesis
relationship: RO:0002213 GO:0001525 ! positively regulates angiogenesis

[Term]
id: GO:0045769
name: negative regulation of asymmetric cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "down regulation of asymmetric cell division" EXACT []
synonym: "down-regulation of asymmetric cell division" EXACT []
synonym: "downregulation of asymmetric cell division" EXACT []
synonym: "inhibition of asymmetric cell division" NARROW []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051782 ! negative regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division
relationship: RO:0002212 GO:0008356 ! negatively regulates asymmetric cell division

[Term]
id: GO:0045770
name: positive regulation of asymmetric cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "activation of asymmetric cell division" NARROW []
synonym: "stimulation of asymmetric cell division" NARROW []
synonym: "up regulation of asymmetric cell division" EXACT []
synonym: "up-regulation of asymmetric cell division" EXACT []
synonym: "upregulation of asymmetric cell division" EXACT []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051781 ! positive regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division
relationship: RO:0002213 GO:0008356 ! positively regulates asymmetric cell division

[Term]
id: GO:0045778
name: positive regulation of ossification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "activation of ossification" NARROW []
synonym: "positive regulation of bone biosynthesis" EXACT []
synonym: "positive regulation of bone formation" EXACT []
synonym: "stimulation of ossification" NARROW []
synonym: "up regulation of ossification" EXACT []
synonym: "up-regulation of ossification" EXACT []
synonym: "upregulation of ossification" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001503 ! positively regulates ossification
relationship: RO:0002213 GO:0001503 ! positively regulates ossification

[Term]
id: GO:0045779
name: negative regulation of bone resorption
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "down regulation of bone resorption" EXACT []
synonym: "down-regulation of bone resorption" EXACT []
synonym: "downregulation of bone resorption" EXACT []
synonym: "inhibition of bone resorption" NARROW []
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0046851 ! negative regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045453 ! negatively regulates bone resorption
relationship: RO:0002212 GO:0045453 ! negatively regulates bone resorption

[Term]
id: GO:0045780
name: positive regulation of bone resorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "activation of bone resorption" NARROW []
synonym: "stimulation of bone resorption" NARROW []
synonym: "up regulation of bone resorption" EXACT []
synonym: "up-regulation of bone resorption" EXACT []
synonym: "upregulation of bone resorption" EXACT []
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045453 ! positively regulates bone resorption
relationship: RO:0002213 GO:0045453 ! positively regulates bone resorption

[Term]
id: GO:0045785
name: positive regulation of cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "activation of cell adhesion" NARROW []
synonym: "stimulation of cell adhesion" NARROW []
synonym: "up regulation of cell adhesion" EXACT []
synonym: "up-regulation of cell adhesion" EXACT []
synonym: "upregulation of cell adhesion" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007155 ! positively regulates cell adhesion
relationship: RO:0002213 GO:0007155 ! positively regulates cell adhesion

[Term]
id: GO:0045786
name: negative regulation of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through cell cycle" EXACT []
synonym: "down-regulation of progression through cell cycle" EXACT []
synonym: "downregulation of progression through cell cycle" EXACT []
synonym: "inhibition of progression through cell cycle" NARROW []
synonym: "negative regulation of cell cycle progression" EXACT []
synonym: "negative regulation of progression through cell cycle" EXACT []
xref: Reactome:R-HSA-193670 "p75NTR negatively regulates cell cycle via SC1"
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007049 ! negatively regulates cell cycle
relationship: RO:0002212 GO:0007049 ! negatively regulates cell cycle

[Term]
id: GO:0045787
name: positive regulation of cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
synonym: "activation of progression through cell cycle" NARROW []
synonym: "positive regulation of cell cycle progression" EXACT []
synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through cell cycle" NARROW []
synonym: "up regulation of progression through cell cycle" EXACT []
synonym: "up-regulation of progression through cell cycle" EXACT []
synonym: "upregulation of progression through cell cycle" EXACT []
xref: Reactome:R-HSA-8849470 "PTK6 Regulates Cell Cycle"
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007049 ! positively regulates cell cycle
relationship: RO:0002213 GO:0007049 ! positively regulates cell cycle

[Term]
id: GO:0045806
name: negative regulation of endocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "down regulation of endocytosis" EXACT []
synonym: "down-regulation of endocytosis" EXACT []
synonym: "downregulation of endocytosis" EXACT []
synonym: "inhibition of endocytosis" NARROW []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006897 ! negatively regulates endocytosis
relationship: RO:0002212 GO:0006897 ! negatively regulates endocytosis

[Term]
id: GO:0045807
name: positive regulation of endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "activation of endocytosis" NARROW []
synonym: "stimulation of endocytosis" NARROW []
synonym: "up regulation of endocytosis" EXACT []
synonym: "up-regulation of endocytosis" EXACT []
synonym: "upregulation of endocytosis" EXACT []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006897 ! positively regulates endocytosis
relationship: RO:0002213 GO:0006897 ! positively regulates endocytosis

[Term]
id: GO:0045814
name: negative regulation of gene expression, epigenetic
namespace: biological_process
def: "An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]
synonym: "down regulation of gene expression, epigenetic" EXACT []
synonym: "down-regulation of gene expression, epigenetic" EXACT []
synonym: "downregulation of gene expression, epigenetic" EXACT []
synonym: "gene silencing" RELATED []
synonym: "inhibition of gene expression, epigenetic" NARROW []
xref: Reactome:R-HSA-212300 "PRC2 methylates histones and DNA"
xref: Reactome:R-HSA-5250941 "Negative epigenetic regulation of rRNA expression"
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0040029 ! epigenetic regulation of gene expression

[Term]
id: GO:0045822
name: negative regulation of heart contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "down regulation of heart contraction" EXACT []
synonym: "down-regulation of heart contraction" EXACT []
synonym: "downregulation of heart contraction" EXACT []
synonym: "inhibition of heart contraction" NARROW []
synonym: "negative regulation of cardiac contraction" RELATED []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060047 ! negatively regulates heart contraction
relationship: RO:0002212 GO:0060047 ! negatively regulates heart contraction

[Term]
id: GO:0045823
name: positive regulation of heart contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "activation of heart contraction" NARROW []
synonym: "positive regulation of cardiac contraction" EXACT []
synonym: "stimulation of heart contraction" NARROW []
synonym: "up regulation of heart contraction" EXACT []
synonym: "up-regulation of heart contraction" EXACT []
synonym: "upregulation of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060047 ! positively regulates heart contraction
relationship: RO:0002213 GO:0060047 ! positively regulates heart contraction

[Term]
id: GO:0045824
name: negative regulation of innate immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
synonym: "down regulation of innate immune response" EXACT []
synonym: "down-regulation of innate immune response" EXACT []
synonym: "downregulation of innate immune response" EXACT []
synonym: "inhibition of innate immune response" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045087 ! negatively regulates innate immune response
relationship: RO:0002212 GO:0045087 ! negatively regulates innate immune response

[Term]
id: GO:0045833
name: negative regulation of lipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "down regulation of lipid metabolic process" EXACT []
synonym: "down-regulation of lipid metabolic process" EXACT []
synonym: "downregulation of lipid metabolic process" EXACT []
synonym: "inhibition of lipid metabolic process" NARROW []
synonym: "negative regulation of lipid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process
relationship: RO:0002212 GO:0006629 ! negatively regulates lipid metabolic process

[Term]
id: GO:0045834
name: positive regulation of lipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "activation of lipid metabolic process" NARROW []
synonym: "positive regulation of lipid metabolism" EXACT []
synonym: "stimulation of lipid metabolic process" NARROW []
synonym: "up regulation of lipid metabolic process" EXACT []
synonym: "up-regulation of lipid metabolic process" EXACT []
synonym: "upregulation of lipid metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process
relationship: RO:0002213 GO:0006629 ! positively regulates lipid metabolic process

[Term]
id: GO:0045835
name: negative regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "down regulation of meiosis" EXACT []
synonym: "down-regulation of meiosis" EXACT []
synonym: "downregulation of meiosis" EXACT []
synonym: "inhibition of meiosis" NARROW []
synonym: "negative regulation of meiosis" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division
relationship: RO:0002212 GO:0140013 ! negatively regulates meiotic nuclear division

[Term]
id: GO:0045836
name: positive regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "activation of meiosis" NARROW []
synonym: "positive regulation of meiosis" EXACT []
synonym: "stimulation of meiosis" NARROW []
synonym: "up regulation of meiosis" EXACT []
synonym: "up-regulation of meiosis" EXACT []
synonym: "upregulation of meiosis" EXACT []
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division
relationship: RO:0002213 GO:0140013 ! positively regulates meiotic nuclear division

[Term]
id: GO:0045839
name: negative regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of mitosis" EXACT []
synonym: "down-regulation of mitosis" EXACT []
synonym: "downregulation of mitosis" EXACT []
synonym: "inhibition of mitosis" NARROW []
synonym: "negative regulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division
relationship: RO:0002212 GO:0140014 ! negatively regulates mitotic nuclear division

[Term]
id: GO:0045840
name: positive regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "activation of mitosis" NARROW []
synonym: "mitogenic activity" NARROW []
synonym: "positive regulation of mitosis" EXACT []
synonym: "stimulation of mitosis" NARROW []
synonym: "up regulation of mitosis" EXACT []
synonym: "up-regulation of mitosis" EXACT []
synonym: "upregulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division
relationship: RO:0002213 GO:0140014 ! positively regulates mitotic nuclear division

[Term]
id: GO:0045843
name: negative regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "down regulation of striated muscle development" EXACT []
synonym: "down-regulation of striated muscle development" EXACT []
synonym: "downregulation of striated muscle development" EXACT []
synonym: "inhibition of striated muscle development" NARROW []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048635 ! negative regulation of muscle organ development
is_a: GO:1901862 ! negative regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development
relationship: RO:0002212 GO:0014706 ! negatively regulates striated muscle tissue development

[Term]
id: GO:0045844
name: positive regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "activation of striated muscle development" NARROW []
synonym: "stimulation of striated muscle development" NARROW []
synonym: "up regulation of striated muscle development" EXACT []
synonym: "up-regulation of striated muscle development" EXACT []
synonym: "upregulation of striated muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048636 ! positive regulation of muscle organ development
is_a: GO:1901863 ! positive regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development
relationship: RO:0002213 GO:0014706 ! positively regulates striated muscle tissue development

[Term]
id: GO:0045900
name: negative regulation of translational elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]
synonym: "down regulation of translational elongation" EXACT []
synonym: "down-regulation of translational elongation" EXACT []
synonym: "downregulation of translational elongation" EXACT []
synonym: "inhibition of translational elongation" NARROW []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0017148 ! negative regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006414 ! negatively regulates translational elongation
relationship: RO:0002212 GO:0006414 ! negatively regulates translational elongation

[Term]
id: GO:0045901
name: positive regulation of translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]
synonym: "activation of translational elongation" NARROW []
synonym: "stimulation of translational elongation" NARROW []
synonym: "up regulation of translational elongation" EXACT []
synonym: "up-regulation of translational elongation" EXACT []
synonym: "upregulation of translational elongation" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006414 ! positively regulates translational elongation
relationship: RO:0002213 GO:0006414 ! positively regulates translational elongation

[Term]
id: GO:0045904
name: negative regulation of translational termination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators]
synonym: "down regulation of translational termination" EXACT []
synonym: "down-regulation of translational termination" EXACT []
synonym: "downregulation of translational termination" EXACT []
synonym: "inhibition of translational termination" NARROW []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006415 ! negatively regulates translational termination
relationship: RO:0002212 GO:0006415 ! negatively regulates translational termination

[Term]
id: GO:0045905
name: positive regulation of translational termination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]
synonym: "activation of translational termination" NARROW []
synonym: "stimulation of translational termination" NARROW []
synonym: "up regulation of translational termination" EXACT []
synonym: "up-regulation of translational termination" EXACT []
synonym: "upregulation of translational termination" EXACT []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006415 ! positively regulates translational termination
relationship: RO:0002213 GO:0006415 ! positively regulates translational termination

[Term]
id: GO:0045912
name: negative regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
synonym: "down regulation of carbohydrate metabolic process" EXACT []
synonym: "down-regulation of carbohydrate metabolic process" EXACT []
synonym: "downregulation of carbohydrate metabolic process" EXACT []
synonym: "inhibition of carbohydrate metabolic process" NARROW []
synonym: "negative regulation of carbohydrate metabolism" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process
relationship: RO:0002212 GO:0005975 ! negatively regulates carbohydrate metabolic process

[Term]
id: GO:0045913
name: positive regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
synonym: "activation of carbohydrate metabolic process" NARROW []
synonym: "positive regulation of carbohydrate metabolism" EXACT []
synonym: "stimulation of carbohydrate metabolic process" NARROW []
synonym: "up regulation of carbohydrate metabolic process" EXACT []
synonym: "up-regulation of carbohydrate metabolic process" EXACT []
synonym: "upregulation of carbohydrate metabolic process" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process
relationship: RO:0002213 GO:0005975 ! positively regulates carbohydrate metabolic process

[Term]
id: GO:0045920
name: negative regulation of exocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "down regulation of exocytosis" EXACT []
synonym: "down-regulation of exocytosis" EXACT []
synonym: "downregulation of exocytosis" EXACT []
synonym: "inhibition of exocytosis" NARROW []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006887 ! negatively regulates exocytosis
relationship: RO:0002212 GO:0006887 ! negatively regulates exocytosis

[Term]
id: GO:0045921
name: positive regulation of exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "activation of exocytosis" NARROW []
synonym: "stimulation of exocytosis" NARROW []
synonym: "up regulation of exocytosis" EXACT []
synonym: "up-regulation of exocytosis" EXACT []
synonym: "upregulation of exocytosis" EXACT []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006887 ! positively regulates exocytosis
relationship: RO:0002213 GO:0006887 ! positively regulates exocytosis

[Term]
id: GO:0045926
name: negative regulation of growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
synonym: "down regulation of growth" EXACT []
synonym: "down-regulation of growth" EXACT []
synonym: "downregulation of growth" EXACT []
synonym: "inhibition of growth" NARROW []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0040007 ! negatively regulates growth
relationship: RO:0002212 GO:0040007 ! negatively regulates growth

[Term]
id: GO:0045927
name: positive regulation of growth
namespace: biological_process
def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
synonym: "activation of growth" NARROW []
synonym: "stimulation of growth" NARROW []
synonym: "up regulation of growth" EXACT []
synonym: "up-regulation of growth" EXACT []
synonym: "upregulation of growth" EXACT []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0040007 ! positively regulates growth
relationship: RO:0002213 GO:0040007 ! positively regulates growth

[Term]
id: GO:0045930
name: negative regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
synonym: "downregulation of progression through mitotic cell cycle" EXACT []
synonym: "inhibition of progression through mitotic cell cycle" NARROW []
synonym: "negative regulation of mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
xref: Reactome:R-HSA-8854050 "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle
relationship: RO:0002212 GO:0000278 ! negatively regulates mitotic cell cycle

[Term]
id: GO:0045931
name: positive regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through mitotic cell cycle" NARROW []
synonym: "positive regulation of mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through mitotic cell cycle" NARROW []
synonym: "up regulation of progression through mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
synonym: "upregulation of progression through mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045787 ! positive regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle
relationship: RO:0002213 GO:0000278 ! positively regulates mitotic cell cycle

[Term]
id: GO:0045932
name: negative regulation of muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "down regulation of muscle contraction" EXACT []
synonym: "down-regulation of muscle contraction" EXACT []
synonym: "downregulation of muscle contraction" EXACT []
synonym: "inhibition of muscle contraction" NARROW []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006936 ! negatively regulates muscle contraction
relationship: RO:0002212 GO:0006936 ! negatively regulates muscle contraction

[Term]
id: GO:0045933
name: positive regulation of muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "activation of muscle contraction" NARROW []
synonym: "stimulation of muscle contraction" NARROW []
synonym: "up regulation of muscle contraction" EXACT []
synonym: "up-regulation of muscle contraction" EXACT []
synonym: "upregulation of muscle contraction" EXACT []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006936 ! positively regulates muscle contraction
relationship: RO:0002213 GO:0006936 ! positively regulates muscle contraction

[Term]
id: GO:0045934
name: negative regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process
relationship: RO:0002212 GO:0006139 ! negatively regulates nucleobase-containing compound metabolic process

[Term]
id: GO:0045936
name: negative regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "down regulation of phosphate metabolic process" EXACT []
synonym: "down-regulation of phosphate metabolic process" EXACT []
synonym: "downregulation of phosphate metabolic process" EXACT []
synonym: "inhibition of phosphate metabolic process" NARROW []
synonym: "negative regulation of phosphate metabolism" EXACT []
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006796 ! negatively regulates phosphate-containing compound metabolic process
relationship: RO:0002212 GO:0006796 ! negatively regulates phosphate-containing compound metabolic process

[Term]
id: GO:0045937
name: positive regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "activation of phosphate metabolic process" NARROW []
synonym: "positive regulation of phosphate metabolism" EXACT []
synonym: "stimulation of phosphate metabolic process" NARROW []
synonym: "up regulation of phosphate metabolic process" EXACT []
synonym: "up-regulation of phosphate metabolic process" EXACT []
synonym: "upregulation of phosphate metabolic process" EXACT []
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006796 ! positively regulates phosphate-containing compound metabolic process
relationship: RO:0002213 GO:0006796 ! positively regulates phosphate-containing compound metabolic process

[Term]
id: GO:0045939
name: negative regulation of steroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "down regulation of steroid metabolic process" EXACT []
synonym: "down-regulation of steroid metabolic process" EXACT []
synonym: "downregulation of steroid metabolic process" EXACT []
synonym: "inhibition of steroid metabolic process" NARROW []
synonym: "negative regulation of steroid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process
relationship: RO:0002212 GO:0008202 ! negatively regulates steroid metabolic process

[Term]
id: GO:0045940
name: positive regulation of steroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "activation of steroid metabolic process" NARROW []
synonym: "positive regulation of steroid metabolism" EXACT []
synonym: "stimulation of steroid metabolic process" NARROW []
synonym: "up regulation of steroid metabolic process" EXACT []
synonym: "up-regulation of steroid metabolic process" EXACT []
synonym: "upregulation of steroid metabolic process" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process
relationship: RO:0002213 GO:0008202 ! positively regulates steroid metabolic process

[Term]
id: GO:0045947
name: negative regulation of translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
synonym: "down regulation of translational initiation" EXACT []
synonym: "down-regulation of translational initiation" EXACT []
synonym: "downregulation of translational initiation" EXACT []
synonym: "inhibition of translational initiation" NARROW []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0017148 ! negative regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational initiation
relationship: RO:0002212 GO:0006413 ! negatively regulates translational initiation

[Term]
id: GO:0045948
name: positive regulation of translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]
synonym: "activation of translational initiation" NARROW []
synonym: "stimulation of translational initiation" NARROW []
synonym: "up regulation of translational initiation" EXACT []
synonym: "up-regulation of translational initiation" EXACT []
synonym: "upregulation of translational initiation" EXACT []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006413 ! positively regulates translational initiation
relationship: RO:0002213 GO:0006413 ! positively regulates translational initiation

[Term]
id: GO:0045963
name: negative regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "down regulation of dopamine metabolic process" EXACT []
synonym: "down-regulation of dopamine metabolic process" EXACT []
synonym: "downregulation of dopamine metabolic process" EXACT []
synonym: "inhibition of dopamine metabolic process" NARROW []
synonym: "negative regulation of dopamine metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0042053 ! regulation of dopamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042417 ! negatively regulates dopamine metabolic process
relationship: RO:0002212 GO:0042417 ! negatively regulates dopamine metabolic process

[Term]
id: GO:0045964
name: positive regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "activation of dopamine metabolic process" NARROW []
synonym: "positive regulation of dopamine metabolism" EXACT []
synonym: "stimulation of dopamine metabolic process" NARROW []
synonym: "up regulation of dopamine metabolic process" EXACT []
synonym: "up-regulation of dopamine metabolic process" EXACT []
synonym: "upregulation of dopamine metabolic process" EXACT []
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0042053 ! regulation of dopamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042417 ! positively regulates dopamine metabolic process
relationship: RO:0002213 GO:0042417 ! positively regulates dopamine metabolic process

[Term]
id: GO:0045986
name: negative regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of smooth muscle contraction" EXACT []
synonym: "down-regulation of smooth muscle contraction" EXACT []
synonym: "downregulation of smooth muscle contraction" EXACT []
synonym: "inhibition of smooth muscle contraction" NARROW []
synonym: "smooth muscle relaxation" RELATED []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction
relationship: RO:0002212 GO:0006939 ! negatively regulates smooth muscle contraction

[Term]
id: GO:0045987
name: positive regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "activation of smooth muscle contraction" NARROW []
synonym: "stimulation of smooth muscle contraction" NARROW []
synonym: "up regulation of smooth muscle contraction" EXACT []
synonym: "up-regulation of smooth muscle contraction" EXACT []
synonym: "upregulation of smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction
relationship: RO:0002213 GO:0006939 ! positively regulates smooth muscle contraction

[Term]
id: GO:0045988
name: negative regulation of striated muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "down regulation of striated muscle contraction" EXACT []
synonym: "down-regulation of striated muscle contraction" EXACT []
synonym: "downregulation of striated muscle contraction" EXACT []
synonym: "inhibition of striated muscle contraction" NARROW []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction
relationship: RO:0002212 GO:0006941 ! negatively regulates striated muscle contraction

[Term]
id: GO:0045989
name: positive regulation of striated muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "activation of striated muscle contraction" NARROW []
synonym: "stimulation of striated muscle contraction" NARROW []
synonym: "up regulation of striated muscle contraction" EXACT []
synonym: "up-regulation of striated muscle contraction" EXACT []
synonym: "upregulation of striated muscle contraction" EXACT []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction
relationship: RO:0002213 GO:0006941 ! positively regulates striated muscle contraction

[Term]
id: GO:0045992
name: negative regulation of embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "down regulation of embryonic development" EXACT []
synonym: "down-regulation of embryonic development" EXACT []
synonym: "downregulation of embryonic development" EXACT []
synonym: "inhibition of embryonic development" NARROW []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009790 ! negatively regulates embryo development
relationship: RO:0002212 GO:0009790 ! negatively regulates embryo development

[Term]
id: GO:0045995
name: regulation of embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009790 ! regulates embryo development
relationship: RO:0002211 GO:0009790 ! regulates embryo development

[Term]
id: GO:0046013
name: regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "regulation of resting T cell proliferation" EXACT []
synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "regulation of T-cell homeostatic proliferation" EXACT []
synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001777 ! regulates T cell homeostatic proliferation
relationship: RO:0002211 GO:0001777 ! regulates T cell homeostatic proliferation

[Term]
id: GO:0046014
name: negative regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "down regulation of T cell homeostatic proliferation" EXACT []
synonym: "down-regulation of T cell homeostatic proliferation" EXACT []
synonym: "downregulation of T cell homeostatic proliferation" EXACT []
synonym: "inhibition of T cell homeostatic proliferation" NARROW []
synonym: "negative regulation of resting T cell proliferation" EXACT []
synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "negative regulation of T-cell homeostatic proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001777 ! negatively regulates T cell homeostatic proliferation
relationship: RO:0002212 GO:0001777 ! negatively regulates T cell homeostatic proliferation

[Term]
id: GO:0046112
name: nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
synonym: "nucleobase anabolism" EXACT []
synonym: "nucleobase biosynthesis" EXACT []
synonym: "nucleobase formation" EXACT []
synonym: "nucleobase synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009112 ! nucleobase metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18282 ! has primary output nucleobase
relationship: RO:0004008 CHEBI:18282 ! has primary output nucleobase

[Term]
id: GO:0046165
name: alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]
synonym: "alcohol anabolism" EXACT []
synonym: "alcohol biosynthesis" EXACT []
synonym: "alcohol formation" EXACT []
synonym: "alcohol synthesis" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0046173
name: polyol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]
synonym: "polyhydric alcohol biosynthetic process" EXACT []
synonym: "polyol anabolism" EXACT []
synonym: "polyol biosynthesis" EXACT []
synonym: "polyol formation" EXACT []
synonym: "polyol synthesis" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0046189
name: phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai]
synonym: "phenol-containing compound anabolism" EXACT []
synonym: "phenol-containing compound biosynthesis" EXACT []
synonym: "phenol-containing compound formation" EXACT []
synonym: "phenol-containing compound synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33853 ! has primary output phenols
relationship: RO:0004008 CHEBI:33853 ! has primary output phenols

[Term]
id: GO:0046394
name: carboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "carboxylic acid anabolism" EXACT []
synonym: "carboxylic acid biosynthesis" EXACT []
synonym: "carboxylic acid formation" EXACT []
synonym: "carboxylic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:29067 ! has primary output carboxylic acid anion
relationship: RO:0004008 CHEBI:29067 ! has primary output carboxylic acid anion

[Term]
id: GO:0046395
name: carboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "carboxylic acid breakdown" EXACT []
synonym: "carboxylic acid catabolism" EXACT []
synonym: "carboxylic acid degradation" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion
relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion

[Term]
id: GO:0046466
name: membrane lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
synonym: "membrane lipid breakdown" EXACT []
synonym: "membrane lipid catabolism" EXACT []
synonym: "membrane lipid degradation" EXACT []
synonym: "membrane lipid peroxidation" BROAD [GOC:tb]
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0016042 ! lipid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid

[Term]
id: GO:0046467
name: membrane lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
synonym: "membrane lipid anabolism" EXACT []
synonym: "membrane lipid biosynthesis" EXACT []
synonym: "membrane lipid formation" EXACT []
synonym: "membrane lipid synthesis" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: BFO:0000066 GO:0016020 ! occurs in membrane
intersection_of: RO:0004008 CHEBI:18059 ! has primary output lipid

[Term]
id: GO:0046530
name: photoreceptor cell differentiation
namespace: biological_process
def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell
relationship: RO:0002315 CL:0000210 ! results in acquisition of features of photoreceptor cell

[Term]
id: GO:0046532
name: regulation of photoreceptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation
relationship: RO:0002211 GO:0046530 ! regulates photoreceptor cell differentiation

[Term]
id: GO:0046533
name: negative regulation of photoreceptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "down regulation of photoreceptor cell differentiation" EXACT []
synonym: "down regulation of photoreceptor differentiation" EXACT []
synonym: "down-regulation of photoreceptor cell differentiation" EXACT []
synonym: "down-regulation of photoreceptor differentiation" EXACT []
synonym: "downregulation of photoreceptor cell differentiation" EXACT []
synonym: "downregulation of photoreceptor differentiation" EXACT []
synonym: "inhibition of photoreceptor cell differentiation" NARROW []
synonym: "inhibition of photoreceptor differentiation" NARROW []
synonym: "negative regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation
relationship: RO:0002212 GO:0046530 ! negatively regulates photoreceptor cell differentiation

[Term]
id: GO:0046534
name: positive regulation of photoreceptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "activation of photoreceptor cell differentiation" NARROW []
synonym: "activation of photoreceptor differentiation" NARROW []
synonym: "positive regulation of photoreceptor differentiation" EXACT []
synonym: "stimulation of photoreceptor cell differentiation" NARROW []
synonym: "stimulation of photoreceptor differentiation" NARROW []
synonym: "up regulation of photoreceptor cell differentiation" EXACT []
synonym: "up regulation of photoreceptor differentiation" EXACT []
synonym: "up-regulation of photoreceptor cell differentiation" EXACT []
synonym: "up-regulation of photoreceptor differentiation" EXACT []
synonym: "upregulation of photoreceptor cell differentiation" EXACT []
synonym: "upregulation of photoreceptor differentiation" EXACT []
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation
relationship: RO:0002213 GO:0046530 ! positively regulates photoreceptor cell differentiation

[Term]
id: GO:0046545
name: development of primary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: BFO:0000050 GO:0046660 ! part of female sex differentiation

[Term]
id: GO:0046548
name: retinal rod cell development
namespace: biological_process
def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000604 ! results in development of retinal rod cell
relationship: BFO:0000050 GO:0060221 ! part of retinal rod cell differentiation
relationship: RO:0002296 CL:0000604 ! results in development of retinal rod cell

[Term]
id: GO:0046549
name: retinal cone cell development
namespace: biological_process
def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000573 ! results in development of retinal cone cell
relationship: BFO:0000050 GO:0042670 ! part of retinal cone cell differentiation
relationship: RO:0002296 CL:0000573 ! results in development of retinal cone cell

[Term]
id: GO:0046620
name: regulation of organ growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035265 ! regulates organ growth
relationship: RO:0002211 GO:0035265 ! regulates organ growth

[Term]
id: GO:0046621
name: negative regulation of organ growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035265 ! negatively regulates organ growth
relationship: RO:0002212 GO:0035265 ! negatively regulates organ growth

[Term]
id: GO:0046622
name: positive regulation of organ growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035265 ! positively regulates organ growth
relationship: RO:0002213 GO:0035265 ! positively regulates organ growth

[Term]
id: GO:0046649
name: lymphocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000542 ! has primary input lymphocyte
relationship: RO:0004009 CL:0000542 ! has primary input lymphocyte

[Term]
id: GO:0046651
name: lymphocyte proliferation
namespace: biological_process
def: "The expansion of a lymphocyte population by cell division." [GOC:ai]
is_a: GO:0032943 ! mononuclear cell proliferation
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte
relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte

[Term]
id: GO:0046660
name: female sex differentiation
namespace: biological_process
def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development

[Term]
id: GO:0046666
name: retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the developing retina." [GOC:bf]
synonym: "programmed cell death, retina cells" EXACT []
synonym: "programmed cell death, retinal cells" EXACT []
synonym: "retina cell programmed cell death" EXACT []
synonym: "retina programmed cell death" EXACT []
synonym: "retinal programmed cell death" EXACT []
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: BFO:0000050 GO:0048592 ! part of eye morphogenesis

[Term]
id: GO:0046667
name: compound eye retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
is_a: GO:0046666 ! retinal cell programmed cell death
intersection_of: GO:0046666 ! retinal cell programmed cell death
intersection_of: RO:0002299 UBERON:0000018 ! results in maturation of compound eye
relationship: BFO:0000050 GO:0001745 ! part of compound eye morphogenesis
relationship: RO:0002299 UBERON:0000018 ! results in maturation of compound eye

[Term]
id: GO:0046668
name: regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death
relationship: RO:0002211 GO:0046666 ! regulates retinal cell programmed cell death

[Term]
id: GO:0046669
name: regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death
relationship: RO:0002211 GO:0046667 ! regulates compound eye retinal cell programmed cell death

[Term]
id: GO:0046670
name: positive regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "activation of retinal programmed cell death" NARROW []
synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb]
synonym: "stimulation of retinal programmed cell death" NARROW []
synonym: "up regulation of retinal programmed cell death" EXACT []
synonym: "up-regulation of retinal programmed cell death" EXACT []
synonym: "upregulation of retinal programmed cell death" EXACT []
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death
relationship: RO:0002213 GO:0046666 ! positively regulates retinal cell programmed cell death

[Term]
id: GO:0046671
name: negative regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "down regulation of retinal programmed cell death" EXACT []
synonym: "down-regulation of retinal programmed cell death" EXACT []
synonym: "downregulation of retinal programmed cell death" EXACT []
synonym: "inhibition of retinal programmed cell death" NARROW []
synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death
relationship: RO:0002212 GO:0046666 ! negatively regulates retinal cell programmed cell death

[Term]
id: GO:0046672
name: positive regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "activation of retinal cell programmed cell death" BROAD []
synonym: "positive regulation of retinal cell programmed cell death" BROAD []
synonym: "stimulation of retinal cell programmed cell death" BROAD []
synonym: "up regulation of retinal cell programmed cell death" BROAD []
synonym: "up-regulation of retinal cell programmed cell death" BROAD []
synonym: "upregulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death
relationship: RO:0002213 GO:0046667 ! positively regulates compound eye retinal cell programmed cell death

[Term]
id: GO:0046673
name: negative regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "down regulation of retinal cell programmed cell death" BROAD []
synonym: "down-regulation of retinal cell programmed cell death" BROAD []
synonym: "downregulation of retinal cell programmed cell death" BROAD []
synonym: "inhibition of retinal cell programmed cell death" BROAD []
synonym: "negative regulation of retina cell programmed cell death" BROAD []
synonym: "negative regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death
relationship: RO:0002212 GO:0046667 ! negatively regulates compound eye retinal cell programmed cell death

[Term]
id: GO:0046716
name: muscle cell cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb]
synonym: "muscle homeostasis" RELATED [GOC:dph]
is_a: GO:0019725 ! cellular homeostasis
intersection_of: GO:0019725 ! cellular homeostasis
intersection_of: BFO:0000066 CL:0000187 ! occurs in muscle cell
relationship: BFO:0000066 CL:0000187 ! occurs in muscle cell

[Term]
id: GO:0046717
name: acid secretion
namespace: biological_process
def: "The controlled release of acid by a cell or a tissue." [GOC:ai]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0046785
name: microtubule polymerization
namespace: biological_process
def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]
synonym: "microtubule assembly" EXACT []
synonym: "microtubule formation" RELATED []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005874 ! results in assembly of microtubule
relationship: RO:0002224 GO:0007020 ! starts with microtubule nucleation
relationship: RO:0002588 GO:0005874 ! results in assembly of microtubule

[Term]
id: GO:0046822
name: regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006913 ! regulates nucleocytoplasmic transport
relationship: RO:0002211 GO:0006913 ! regulates nucleocytoplasmic transport

[Term]
id: GO:0046823
name: negative regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf]
synonym: "down regulation of nucleocytoplasmic transport" EXACT []
synonym: "down-regulation of nucleocytoplasmic transport" EXACT []
synonym: "downregulation of nucleocytoplasmic transport" EXACT []
synonym: "inhibition of nucleocytoplasmic transport" NARROW []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006913 ! negatively regulates nucleocytoplasmic transport
relationship: RO:0002212 GO:0006913 ! negatively regulates nucleocytoplasmic transport

[Term]
id: GO:0046824
name: positive regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
synonym: "activation of nucleocytoplasmic transport" NARROW []
synonym: "stimulation of nucleocytoplasmic transport" NARROW []
synonym: "up regulation of nucleocytoplasmic transport" EXACT []
synonym: "up-regulation of nucleocytoplasmic transport" EXACT []
synonym: "upregulation of nucleocytoplasmic transport" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006913 ! positively regulates nucleocytoplasmic transport
relationship: RO:0002213 GO:0006913 ! positively regulates nucleocytoplasmic transport

[Term]
id: GO:0046825
name: regulation of protein export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of protein export from cell nucleus" EXACT []
synonym: "regulation of protein export out of nucleus" EXACT []
synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of protein-nucleus export" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006611 ! regulates protein export from nucleus
relationship: RO:0002211 GO:0006611 ! regulates protein export from nucleus

[Term]
id: GO:0046826
name: negative regulation of protein export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of protein export from nucleus" EXACT []
synonym: "down-regulation of protein export from nucleus" EXACT []
synonym: "downregulation of protein export from nucleus" EXACT []
synonym: "inhibition of protein export from nucleus" NARROW []
synonym: "negative regulation of protein export from cell nucleus" EXACT []
synonym: "negative regulation of protein export out of nucleus" EXACT []
synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of protein-nucleus export" EXACT []
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0051457 ! maintenance of protein location in nucleus
is_a: GO:0090317 ! negative regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006611 ! negatively regulates protein export from nucleus
relationship: RO:0002212 GO:0006611 ! negatively regulates protein export from nucleus

[Term]
id: GO:0046827
name: positive regulation of protein export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of protein export from nucleus" NARROW []
synonym: "positive regulation of protein export from cell nucleus" EXACT []
synonym: "positive regulation of protein export out of nucleus" EXACT []
synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of protein-nucleus export" EXACT []
synonym: "stimulation of protein export from nucleus" NARROW []
synonym: "up regulation of protein export from nucleus" EXACT []
synonym: "up-regulation of protein export from nucleus" EXACT []
synonym: "upregulation of protein export from nucleus" EXACT []
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0090316 ! positive regulation of intracellular protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006611 ! positively regulates protein export from nucleus
relationship: RO:0002213 GO:0006611 ! positively regulates protein export from nucleus

[Term]
id: GO:0046828
name: regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf]
synonym: "regulation of RNA import into cell nucleus" EXACT []
synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of RNA-nucleus import" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006404 ! regulates RNA import into nucleus
relationship: RO:0002211 GO:0006404 ! regulates RNA import into nucleus

[Term]
id: GO:0046829
name: negative regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "down regulation of RNA import into nucleus" EXACT []
synonym: "down-regulation of RNA import into nucleus" EXACT []
synonym: "downregulation of RNA import into nucleus" EXACT []
synonym: "inhibition of RNA import into nucleus" NARROW []
synonym: "negative regulation of RNA import into cell nucleus" EXACT []
synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of RNA-nucleus import" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006404 ! negatively regulates RNA import into nucleus
relationship: RO:0002212 GO:0006404 ! negatively regulates RNA import into nucleus

[Term]
id: GO:0046830
name: positive regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "activation of RNA import into nucleus" NARROW []
synonym: "positive regulation of RNA import into cell nucleus" EXACT []
synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of RNA-nucleus import" EXACT []
synonym: "stimulation of RNA import into nucleus" NARROW []
synonym: "up regulation of RNA import into nucleus" EXACT []
synonym: "up-regulation of RNA import into nucleus" EXACT []
synonym: "upregulation of RNA import into nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006404 ! positively regulates RNA import into nucleus
relationship: RO:0002213 GO:0006404 ! positively regulates RNA import into nucleus

[Term]
id: GO:0046831
name: regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of RNA export from cell nucleus" EXACT []
synonym: "regulation of RNA export out of nucleus" EXACT []
synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of RNA-nucleus export" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006405 ! regulates RNA export from nucleus
relationship: RO:0002211 GO:0006405 ! regulates RNA export from nucleus

[Term]
id: GO:0046832
name: negative regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of RNA export from nucleus" EXACT []
synonym: "down-regulation of RNA export from nucleus" EXACT []
synonym: "downregulation of RNA export from nucleus" EXACT []
synonym: "inhibition of RNA export from nucleus" NARROW []
synonym: "negative regulation of RNA export from cell nucleus" EXACT []
synonym: "negative regulation of RNA export out of nucleus" EXACT []
synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of RNA-nucleus export" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006405 ! negatively regulates RNA export from nucleus
relationship: RO:0002212 GO:0006405 ! negatively regulates RNA export from nucleus

[Term]
id: GO:0046833
name: positive regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of RNA export from nucleus" NARROW []
synonym: "positive regulation of RNA export from cell nucleus" EXACT []
synonym: "positive regulation of RNA export out of nucleus" EXACT []
synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of RNA-nucleus export" EXACT []
synonym: "stimulation of RNA export from nucleus" NARROW []
synonym: "up regulation of RNA export from nucleus" EXACT []
synonym: "up-regulation of RNA export from nucleus" EXACT []
synonym: "upregulation of RNA export from nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006405 ! positively regulates RNA export from nucleus
relationship: RO:0002213 GO:0006405 ! positively regulates RNA export from nucleus

[Term]
id: GO:0046849
name: bone remodeling
namespace: biological_process
def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators]
synonym: "bone remodelling" EXACT []
xref: Wikipedia:Bone_remodeling
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0046850
name: regulation of bone remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai]
synonym: "regulation of bone remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046849 ! regulates bone remodeling
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002211 GO:0046849 ! regulates bone remodeling

[Term]
id: GO:0046851
name: negative regulation of bone remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "down regulation of bone remodeling" EXACT []
synonym: "down-regulation of bone remodeling" EXACT []
synonym: "downregulation of bone remodeling" EXACT []
synonym: "inhibition of bone remodeling" NARROW []
synonym: "negative regulation of bone remodelling" EXACT []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046849 ! negatively regulates bone remodeling
relationship: RO:0002212 GO:0046849 ! negatively regulates bone remodeling

[Term]
id: GO:0046852
name: positive regulation of bone remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "activation of bone remodeling" NARROW []
synonym: "positive regulation of bone remodelling" EXACT []
synonym: "stimulation of bone remodeling" NARROW []
synonym: "up regulation of bone remodeling" EXACT []
synonym: "up-regulation of bone remodeling" EXACT []
synonym: "upregulation of bone remodeling" EXACT []
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046849 ! positively regulates bone remodeling
relationship: RO:0002213 GO:0046849 ! positively regulates bone remodeling

[Term]
id: GO:0046879
name: hormone secretion
namespace: biological_process
def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732]
is_a: GO:0009914 ! hormone transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0046883
name: regulation of hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0023051 ! regulation of signaling
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046879 ! regulates hormone secretion
relationship: RO:0002211 GO:0046879 ! regulates hormone secretion

[Term]
id: GO:0046885
name: regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "regulation of hormone anabolism" EXACT []
synonym: "regulation of hormone biosynthesis" EXACT []
synonym: "regulation of hormone formation" EXACT []
synonym: "regulation of hormone synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042446 ! regulates hormone biosynthetic process
relationship: RO:0002211 GO:0042446 ! regulates hormone biosynthetic process

[Term]
id: GO:0046886
name: positive regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "activation of hormone biosynthetic process" NARROW []
synonym: "positive regulation of hormone anabolism" EXACT []
synonym: "positive regulation of hormone biosynthesis" EXACT []
synonym: "positive regulation of hormone formation" EXACT []
synonym: "positive regulation of hormone synthesis" EXACT []
synonym: "stimulation of hormone biosynthetic process" NARROW []
synonym: "up regulation of hormone biosynthetic process" EXACT []
synonym: "up-regulation of hormone biosynthetic process" EXACT []
synonym: "upregulation of hormone biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042446 ! positively regulates hormone biosynthetic process
relationship: RO:0002213 GO:0042446 ! positively regulates hormone biosynthetic process

[Term]
id: GO:0046887
name: positive regulation of hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "activation of hormone secretion" NARROW []
synonym: "stimulation of hormone secretion" NARROW []
synonym: "up regulation of hormone secretion" EXACT []
synonym: "up-regulation of hormone secretion" EXACT []
synonym: "upregulation of hormone secretion" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046879 ! positively regulates hormone secretion
relationship: RO:0002213 GO:0046879 ! positively regulates hormone secretion

[Term]
id: GO:0046888
name: negative regulation of hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "down regulation of hormone secretion" EXACT []
synonym: "down-regulation of hormone secretion" EXACT []
synonym: "downregulation of hormone secretion" EXACT []
synonym: "inhibition of hormone secretion" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046879 ! negatively regulates hormone secretion
relationship: RO:0002212 GO:0046879 ! negatively regulates hormone secretion

[Term]
id: GO:0046889
name: positive regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "activation of lipid biosynthetic process" NARROW []
synonym: "positive regulation of lipid anabolism" EXACT []
synonym: "positive regulation of lipid biosynthesis" EXACT []
synonym: "positive regulation of lipid formation" EXACT []
synonym: "positive regulation of lipid synthesis" EXACT []
synonym: "positive regulation of lipogenesis" EXACT [GOC:sl]
synonym: "stimulation of lipid biosynthetic process" NARROW []
synonym: "up regulation of lipid biosynthetic process" EXACT []
synonym: "up-regulation of lipid biosynthetic process" EXACT []
synonym: "upregulation of lipid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process
relationship: RO:0002213 GO:0008610 ! positively regulates lipid biosynthetic process

[Term]
id: GO:0046890
name: regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "regulation of lipid anabolism" EXACT []
synonym: "regulation of lipid biosynthesis" EXACT []
synonym: "regulation of lipid formation" EXACT []
synonym: "regulation of lipid synthesis" EXACT []
synonym: "regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process
relationship: RO:0002211 GO:0008610 ! regulates lipid biosynthetic process

[Term]
id: GO:0046903
name: secretion
namespace: biological_process
def: "The controlled release of a substance by a cell or a tissue." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0046907
name: intracellular transport
namespace: biological_process
alt_id: GO:1902582
def: "The directed movement of substances within a cell." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "single organism intracellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism intracellular transport" RELATED []
is_a: GO:0006810 ! transport
is_a: GO:0051641 ! cellular localization
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
relationship: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
created_by: jl
creation_date: 2013-12-18T14:04:50Z

[Term]
id: GO:0046928
name: regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion
relationship: RO:0002211 GO:0007269 ! regulates neurotransmitter secretion

[Term]
id: GO:0046929
name: negative regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]
synonym: "conotoxin activity" NARROW []
synonym: "down regulation of neurotransmitter secretion" EXACT []
synonym: "down-regulation of neurotransmitter secretion" EXACT []
synonym: "downregulation of neurotransmitter secretion" EXACT []
synonym: "inhibition of neurotransmitter secretion" NARROW []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion
relationship: RO:0002212 GO:0007269 ! negatively regulates neurotransmitter secretion

[Term]
id: GO:0046942
name: carboxylic acid transport
namespace: biological_process
def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015849 ! organic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion
relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion

[Term]
id: GO:0046943
name: carboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane"
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion
relationship: BFO:0000050 GO:1905039 ! part of carboxylic acid transmembrane transport
relationship: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion

[Term]
id: GO:0047496
name: vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]
synonym: "microtubule-based vesicle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle

[Term]
id: GO:0047497
name: mitochondrion transport along microtubule
namespace: biological_process
def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
synonym: "mitochondrial migration along microtubule" EXACT []
synonym: "mitochondrial transport along microtubule" EXACT []
is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated
is_a: GO:0072384 ! organelle transport along microtubule
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0048020
name: CCR chemokine receptor binding
namespace: molecular_function
def: "Binding to a CCR chemokine receptor." [GOC:ai]
synonym: "beta chemokine receptor binding" EXACT []
synonym: "beta chemokine receptor ligand" NARROW []
synonym: "CCR chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0048029
name: monosaccharide binding
namespace: molecular_function
def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]
is_a: GO:0030246 ! carbohydrate binding
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0048048
name: embryonic eye morphogenesis
namespace: biological_process
def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048066
name: developmental pigmentation
namespace: biological_process
def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
synonym: "pigmentation during development" RELATED []
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0048070
name: regulation of developmental pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0120305 ! regulation of pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048066 ! regulates developmental pigmentation
relationship: RO:0002211 GO:0048066 ! regulates developmental pigmentation

[Term]
id: GO:0048086
name: negative regulation of developmental pigmentation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of pigmentation" NARROW []
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation
relationship: RO:0002212 GO:0048066 ! negatively regulates developmental pigmentation

[Term]
id: GO:0048087
name: positive regulation of developmental pigmentation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph]
synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation
relationship: RO:0002213 GO:0048066 ! positively regulates developmental pigmentation

[Term]
id: GO:0048102
name: autophagic cell death
namespace: biological_process
def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517]
comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
synonym: "autophagic death" BROAD []
synonym: "autosis" RELATED [PMID:25236395]
synonym: "programmed cell death by autophagy" BROAD [GOC:pr]
synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm]
synonym: "type II programmed cell death" RELATED [GOC:sl]
is_a: GO:0012501 ! programmed cell death
intersection_of: GO:0012501 ! programmed cell death
intersection_of: BFO:0000051 GO:0016236 ! has part macroautophagy
relationship: BFO:0000051 GO:0016236 ! has part macroautophagy

[Term]
id: GO:0048103
name: somatic stem cell division
namespace: biological_process
def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
synonym: "somatic stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000723 ! has primary input somatic stem cell
relationship: RO:0004009 CL:0000723 ! has primary input somatic stem cell

[Term]
id: GO:0048132
name: female germ-line stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
synonym: "female germ-line stem cell renewal" EXACT []
is_a: GO:0098728 ! germline stem cell asymmetric division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: RO:0004009 CL:0000022 ! has primary input female germ line stem cell
relationship: BFO:0000050 GO:0048477 ! part of oogenesis
relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda
relationship: RO:0004009 CL:0000022 ! has primary input female germ line stem cell

[Term]
id: GO:0048143
name: astrocyte activation
namespace: biological_process
def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]
is_a: GO:0061900 ! glial cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000127 ! has primary input astrocyte
relationship: BFO:0000050 GO:0014002 ! part of astrocyte development
relationship: RO:0004009 CL:0000127 ! has primary input astrocyte

[Term]
id: GO:0048144
name: fibroblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000057 ! acts on population of fibroblast
relationship: RO:0012003 CL:0000057 ! acts on population of fibroblast

[Term]
id: GO:0048145
name: regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048144 ! regulates fibroblast proliferation
relationship: RO:0002211 GO:0048144 ! regulates fibroblast proliferation

[Term]
id: GO:0048146
name: positive regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "activation of fibroblast proliferation" NARROW []
synonym: "stimulation of fibroblast proliferation" NARROW []
synonym: "up regulation of fibroblast proliferation" EXACT []
synonym: "up-regulation of fibroblast proliferation" EXACT []
synonym: "upregulation of fibroblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation
relationship: RO:0002213 GO:0048144 ! positively regulates fibroblast proliferation

[Term]
id: GO:0048147
name: negative regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "down regulation of fibroblast proliferation" EXACT []
synonym: "down-regulation of fibroblast proliferation" EXACT []
synonym: "downregulation of fibroblast proliferation" EXACT []
synonym: "inhibition of fibroblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation
relationship: RO:0002212 GO:0048144 ! negatively regulates fibroblast proliferation

[Term]
id: GO:0048193
name: Golgi vesicle transport
namespace: biological_process
def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
subset: goslim_yeast
synonym: "Golgi-derived vesicle transport" RELATED []
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle
relationship: RO:0002344 GO:0005798 ! results in transport to from or in Golgi-associated vesicle

[Term]
id: GO:0048194
name: Golgi vesicle budding
namespace: biological_process
def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle budding" NARROW []
synonym: "Golgi-derived vesicle budding" EXACT []
is_a: GO:0006900 ! vesicle budding from membrane
intersection_of: GO:0006900 ! vesicle budding from membrane
intersection_of: BFO:0000066 GO:0000139 ! occurs in Golgi membrane
intersection_of: RO:0004008 GO:0005798 ! has primary output Golgi-associated vesicle
relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport
relationship: BFO:0000066 GO:0000139 ! occurs in Golgi membrane
relationship: RO:0004008 GO:0005798 ! has primary output Golgi-associated vesicle

[Term]
id: GO:0048199
name: vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle targeting" NARROW []
synonym: "Golgi vesicle targeting" EXACT []
synonym: "vesicle targeting, to, from or within dictyosome" NARROW []
is_a: GO:0006903 ! vesicle targeting
intersection_of: GO:0006903 ! vesicle targeting
intersection_of: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus
intersection_of: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle
relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport
relationship: RO:0002344 GO:0005794 ! results in transport to from or in Golgi apparatus
relationship: RO:0004009 GO:0005798 ! has primary input Golgi-associated vesicle

[Term]
id: GO:0048209
name: regulation of vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "regulation of Golgi vesicle targeting" EXACT []
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi
relationship: RO:0002211 GO:0048199 ! regulates vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048243
name: norepinephrine secretion
namespace: biological_process
def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid]
synonym: "noradrenaline secretion" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0023061 ! signal release
is_a: GO:0050432 ! catecholamine secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:72587 ! has primary input

[Term]
id: GO:0048246
name: macrophage chemotaxis
namespace: biological_process
def: "The movement of a macrophage in response to an external stimulus." [GOC:jid]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:1905517 ! macrophage migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000235 ! results in movement of macrophage

[Term]
id: GO:0048247
name: lymphocyte chemotaxis
namespace: biological_process
def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0072676 ! lymphocyte migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000542 ! results in movement of lymphocyte

[Term]
id: GO:0048251
name: elastic fiber assembly
namespace: biological_process
def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674]
synonym: "elastic fibre assembly" EXACT []
synonym: "elastin fiber assembly" EXACT [GOC:BHF]
synonym: "elastin fibre assembly" EXACT [GOC:BHF]
is_a: GO:0085029 ! extracellular matrix assembly
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0071953 ! results in assembly of elastic fiber
relationship: RO:0002588 GO:0071953 ! results in assembly of elastic fiber

[Term]
id: GO:0048280
name: vesicle fusion with Golgi apparatus
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0007030 ! Golgi organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus
intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle
relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport
relationship: RO:0012008 GO:0005794 ! results in fusion of Golgi apparatus
relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle

[Term]
id: GO:0048284
name: organelle fusion
namespace: biological_process
def: "The creation of a single organelle from two or more organelles." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0043226 ! results in fusion of organelle
relationship: RO:0012008 GO:0043226 ! results in fusion of organelle

[Term]
id: GO:0048285
name: organelle fission
namespace: biological_process
def: "The creation of two or more organelles by division of one organelle." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0009987 ! cellular process
intersection_of: GOREL:0002004 GO:0043226 ! results in fission of organelle
relationship: GOREL:0002004 GO:0043226 ! results in fission of organelle

[Term]
id: GO:0048288
name: nuclear membrane fusion involved in karyogamy
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid]
synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000740 ! nuclear membrane fusion
intersection_of: GO:0000740 ! nuclear membrane fusion
intersection_of: BFO:0000050 GO:0000741 ! part of karyogamy
relationship: BFO:0000050 GO:0000741 ! part of karyogamy

[Term]
id: GO:0048308
name: organelle inheritance
namespace: biological_process
def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048311
name: mitochondrion distribution
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]
synonym: "distribution of mitochondria" EXACT []
synonym: "mitochondrial distribution" EXACT []
synonym: "positioning of mitochondria" RELATED []
is_a: GO:0051646 ! mitochondrion localization

[Term]
id: GO:0048313
name: Golgi inheritance
namespace: biological_process
def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069]
synonym: "Golgi apparatus inheritance" EXACT []
synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi partitioning" EXACT []
xref: Reactome:R-HSA-162658 "Golgi Cisternae Pericentriolar Stack Reorganization"
is_a: GO:0007030 ! Golgi organization
is_a: GO:0048308 ! organelle inheritance
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: GOREL:0002003 GO:0005794 ! results in distribution of Golgi apparatus
relationship: GOREL:0002003 GO:0005794 ! results in distribution of Golgi apparatus

[Term]
id: GO:0048318
name: axial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm
relationship: RO:0002296 UBERON:0003068 ! results in development of axial mesoderm

[Term]
id: GO:0048319
name: axial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm
relationship: BFO:0000050 GO:0048318 ! part of axial mesoderm development
relationship: RO:0002298 UBERON:0003068 ! results in morphogenesis of axial mesoderm

[Term]
id: GO:0048320
name: axial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
xref: Reactome:R-HSA-9796292 "Formation of axial mesoderm"
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003068 ! results in formation of axial mesoderm
relationship: BFO:0000050 GO:0048319 ! part of axial mesoderm morphogenesis
relationship: RO:0002297 UBERON:0003068 ! results in formation of axial mesoderm

[Term]
id: GO:0048332
name: mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm
relationship: BFO:0000050 GO:0007498 ! part of mesoderm development
relationship: RO:0002298 UBERON:0000926 ! results in morphogenesis of mesoderm

[Term]
id: GO:0048333
name: mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh]
synonym: "mesoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell
relationship: BFO:0000050 GO:0001707 ! part of mesoderm formation
relationship: RO:0002315 CL:0000222 ! results in acquisition of features of mesodermal cell

[Term]
id: GO:0048339
name: paraxial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm
relationship: RO:0002296 UBERON:0003077 ! results in development of paraxial mesoderm

[Term]
id: GO:0048340
name: paraxial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm
relationship: BFO:0000050 GO:0048339 ! part of paraxial mesoderm development
relationship: RO:0002298 UBERON:0003077 ! results in morphogenesis of paraxial mesoderm

[Term]
id: GO:0048341
name: paraxial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
xref: Reactome:R-HSA-9793380 "Formation of paraxial mesoderm"
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003077 ! results in formation of paraxial mesoderm
relationship: BFO:0000050 GO:0048340 ! part of paraxial mesoderm morphogenesis
relationship: RO:0002297 UBERON:0003077 ! results in formation of paraxial mesoderm

[Term]
id: GO:0048368
name: lateral mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "lateral plate mesoderm development" EXACT []
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm
relationship: RO:0002296 UBERON:0003081 ! results in development of lateral plate mesoderm

[Term]
id: GO:0048369
name: lateral mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators]
synonym: "lateral plate mesoderm morphogenesis" EXACT []
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm
relationship: BFO:0000050 GO:0048368 ! part of lateral mesoderm development
relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm

[Term]
id: GO:0048370
name: lateral mesoderm formation
namespace: biological_process
def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid]
synonym: "lateral plate mesoderm biosynthesis" EXACT []
synonym: "lateral plate mesoderm formation" EXACT []
xref: Reactome:R-HSA-9758920 "Formation of lateral plate mesoderm"
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm
relationship: BFO:0000050 GO:0048369 ! part of lateral mesoderm morphogenesis
relationship: RO:0002298 UBERON:0003081 ! results in morphogenesis of lateral plate mesoderm

[Term]
id: GO:0048389
name: intermediate mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm
relationship: RO:0002296 UBERON:0003064 ! results in development of intermediate mesoderm

[Term]
id: GO:0048390
name: intermediate mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm
relationship: BFO:0000050 GO:0048389 ! part of intermediate mesoderm development
relationship: RO:0002298 UBERON:0003064 ! results in morphogenesis of intermediate mesoderm

[Term]
id: GO:0048391
name: intermediate mesoderm formation
namespace: biological_process
def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
xref: Reactome:R-HSA-9761174 "Formation of intermediate mesoderm"
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003064 ! results in formation of intermediate mesoderm
relationship: BFO:0000050 GO:0048390 ! part of intermediate mesoderm morphogenesis
relationship: RO:0002297 UBERON:0003064 ! results in formation of intermediate mesoderm

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]
subset: goslim_candida
synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0008150 ! biological_process
intersection_of: RO:0002296 CL:0000000 ! results in development of cell
relationship: BFO:0000050 GO:0030154 ! part of cell differentiation
relationship: RO:0002296 CL:0000000 ! results in development of cell

[Term]
id: GO:0048469
name: cell maturation
namespace: biological_process
def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators]
subset: goslim_pir
synonym: "functional differentiation" RELATED [GOC:dph]
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000000 ! results in maturation of cell
relationship: BFO:0000050 GO:0048468 ! part of cell development
relationship: RO:0002299 CL:0000000 ! results in maturation of cell

[Term]
id: GO:0048477
name: oogenesis
namespace: biological_process
def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
xref: Wikipedia:Oogenesis
is_a: GO:0007281 ! germ cell development
is_a: GO:0007292 ! female gamete generation
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0000025 ! results in development of egg cell
relationship: RO:0002296 CL:0000025 ! results in development of egg cell

[Term]
id: GO:0048483
name: autonomic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002296 UBERON:0002410 ! results in development of autonomic nervous system

[Term]
id: GO:0048485
name: sympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system
relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development
relationship: RO:0002296 UBERON:0000013 ! results in development of sympathetic nervous system

[Term]
id: GO:0048486
name: parasympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000011 ! results in development of parasympathetic nervous system
relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development
relationship: RO:0002296 UBERON:0000011 ! results in development of parasympathetic nervous system

[Term]
id: GO:0048505
name: regulation of timing of cell differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
synonym: "timing of cell differentiation" RELATED []
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0045595 ! regulation of cell differentiation

[Term]
id: GO:0048513
name: animal organ development
namespace: biological_process
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]
synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0048514
name: blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid]
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel
relationship: BFO:0000050 GO:0001568 ! part of blood vessel development
relationship: RO:0002298 UBERON:0001981 ! results in morphogenesis of blood vessel

[Term]
id: GO:0048518
name: positive regulation of biological process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of biological process" NARROW []
synonym: "positive regulation of physiological process" EXACT []
synonym: "stimulation of biological process" NARROW []
synonym: "up regulation of biological process" EXACT []
synonym: "up-regulation of biological process" EXACT []
synonym: "upregulation of biological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008150 ! positively regulates biological_process
relationship: RO:0002213 GO:0008150 ! positively regulates biological_process

[Term]
id: GO:0048519
name: negative regulation of biological process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of biological process" EXACT []
synonym: "down-regulation of biological process" EXACT []
synonym: "downregulation of biological process" EXACT []
synonym: "inhibition of biological process" NARROW []
synonym: "negative regulation of physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008150 ! negatively regulates biological_process
relationship: RO:0002212 GO:0008150 ! negatively regulates biological_process

[Term]
id: GO:0048520
name: positive regulation of behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "activation of behavior" NARROW []
synonym: "stimulation of behavior" NARROW []
synonym: "up regulation of behavior" EXACT []
synonym: "up-regulation of behavior" EXACT []
synonym: "upregulation of behavior" EXACT []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007610 ! positively regulates behavior
relationship: RO:0002213 GO:0007610 ! positively regulates behavior

[Term]
id: GO:0048521
name: negative regulation of behavior
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "down regulation of behavior" EXACT []
synonym: "down-regulation of behavior" EXACT []
synonym: "downregulation of behavior" EXACT []
synonym: "inhibition of behavior" NARROW []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007610 ! negatively regulates behavior
relationship: RO:0002212 GO:0007610 ! negatively regulates behavior

[Term]
id: GO:0048522
name: positive regulation of cellular process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of cellular process" NARROW []
synonym: "positive regulation of cellular physiological process" EXACT []
synonym: "stimulation of cellular process" NARROW []
synonym: "up regulation of cellular process" EXACT []
synonym: "up-regulation of cellular process" EXACT []
synonym: "upregulation of cellular process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009987 ! positively regulates cellular process
relationship: RO:0002213 GO:0009987 ! positively regulates cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular process" EXACT []
synonym: "down-regulation of cellular process" EXACT []
synonym: "downregulation of cellular process" EXACT []
synonym: "inhibition of cellular process" NARROW []
synonym: "negative regulation of cellular physiological process" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009987 ! negatively regulates cellular process
relationship: RO:0002212 GO:0009987 ! negatively regulates cellular process

[Term]
id: GO:0048534
name: hematopoietic or lymphoid organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]
synonym: "haematopoietic or lymphoid organ development" EXACT []
synonym: "haemopoietic or lymphoid organ development" EXACT []
synonym: "hemopoietic or lymphoid organ development" EXACT []
is_a: GO:0048513 ! animal organ development
relationship: BFO:0000050 GO:0002520 ! part of immune system development

[Term]
id: GO:0048539
name: bone marrow development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149]
is_a: GO:0009888 ! tissue development
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002371 ! results in development of bone marrow
relationship: BFO:0000050 GO:0060348 ! part of bone development
relationship: RO:0002296 UBERON:0002371 ! results in development of bone marrow

[Term]
id: GO:0048545
name: response to steroid hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators]
synonym: "response to steroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:26764 ! has primary input
relationship: RO:0004009 CHEBI:26764 ! has primary input

[Term]
id: GO:0048546
name: digestive tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131]
synonym: "alimentary canal morphogenesis" EXACT []
synonym: "digestive tube morphogenesis" EXACT []
synonym: "gastrointestinal tract morphogenesis" EXACT []
synonym: "gut morphogenesis" BROAD [GOC:dph]
synonym: "intestinal morphogenesis" NARROW []
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract
relationship: BFO:0000050 GO:0048565 ! part of digestive tract development
relationship: RO:0002298 UBERON:0001555 ! results in morphogenesis of digestive tract

[Term]
id: GO:0048562
name: embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: BFO:0000050 GO:0048568 ! part of embryonic organ development

[Term]
id: GO:0048565
name: digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
synonym: "gut development" BROAD [GOC:dph]
synonym: "intestinal development" NARROW []
synonym: "intestine development" NARROW []
is_a: GO:0035295 ! tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001555 ! results in development of digestive tract
relationship: BFO:0000050 GO:0055123 ! part of digestive system development
relationship: RO:0002296 UBERON:0001555 ! results in development of digestive tract

[Term]
id: GO:0048568
name: embryonic organ development
namespace: biological_process
def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
synonym: "embryonic organogenesis" EXACT []
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: BFO:0000050 GO:0009790 ! part of embryo development
intersection_of: RO:0002296 UBERON:0000062 ! results in development of organ
relationship: BFO:0000050 GO:0009790 ! part of embryo development
relationship: RO:0002296 UBERON:0000062 ! results in development of organ

[Term]
id: GO:0048570
name: notochord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord
relationship: BFO:0000050 GO:0030903 ! part of notochord development
relationship: RO:0002298 UBERON:0002328 ! results in morphogenesis of notochord

[Term]
id: GO:0048580
name: regulation of post-embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009791 ! regulates post-embryonic development
relationship: RO:0002211 GO:0009791 ! regulates post-embryonic development

[Term]
id: GO:0048581
name: negative regulation of post-embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "down regulation of post-embryonic development" EXACT []
synonym: "down-regulation of post-embryonic development" EXACT []
synonym: "downregulation of post-embryonic development" EXACT []
synonym: "inhibition of post-embryonic development" NARROW []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development
relationship: RO:0002212 GO:0009791 ! negatively regulates post-embryonic development

[Term]
id: GO:0048582
name: positive regulation of post-embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "activation of post-embryonic development" NARROW []
synonym: "stimulation of post-embryonic development" NARROW []
synonym: "up regulation of post-embryonic development" EXACT []
synonym: "up-regulation of post-embryonic development" EXACT []
synonym: "upregulation of post-embryonic development" EXACT []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009791 ! positively regulates post-embryonic development
relationship: RO:0002213 GO:0009791 ! positively regulates post-embryonic development

[Term]
id: GO:0048583
name: regulation of response to stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050896 ! regulates response to stimulus
relationship: RO:0002211 GO:0050896 ! regulates response to stimulus

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "activation of response to stimulus" NARROW []
synonym: "stimulation of response to stimulus" NARROW []
synonym: "up regulation of response to stimulus" EXACT []
synonym: "up-regulation of response to stimulus" EXACT []
synonym: "upregulation of response to stimulus" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050896 ! positively regulates response to stimulus
relationship: RO:0002213 GO:0050896 ! positively regulates response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "down regulation of response to stimulus" EXACT []
synonym: "down-regulation of response to stimulus" EXACT []
synonym: "downregulation of response to stimulus" EXACT []
synonym: "inhibition of response to stimulus" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050896 ! negatively regulates response to stimulus
relationship: RO:0002212 GO:0050896 ! negatively regulates response to stimulus

[Term]
id: GO:0048588
name: developmental cell growth
namespace: biological_process
def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
subset: gocheck_do_not_annotate
synonym: "developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
is_a: GO:0048589 ! developmental growth
relationship: BFO:0000050 GO:0048468 ! part of cell development

[Term]
id: GO:0048589
name: developmental growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
is_a: GO:0040007 ! growth
intersection_of: GO:0040007 ! growth
intersection_of: BFO:0000050 GO:0032502 ! part of developmental process
relationship: BFO:0000050 GO:0032502 ! part of developmental process

[Term]
id: GO:0048592
name: eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0090596 ! sensory organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye
relationship: BFO:0000050 GO:0001654 ! part of eye development
relationship: RO:0002298 UBERON:0000970 ! results in morphogenesis of eye

[Term]
id: GO:0048593
name: camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu]
synonym: "camera-style eye morphogenesis" EXACT [GOC:dph]
is_a: GO:0048592 ! eye morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye
relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development
relationship: RO:0002298 UBERON:0000019 ! results in morphogenesis of camera-type eye

[Term]
id: GO:0048596
name: embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic eye morphogenesis" BROAD []
is_a: GO:0048048 ! embryonic eye morphogenesis
relationship: BFO:0000050 GO:0031076 ! part of embryonic camera-type eye development
relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis

[Term]
id: GO:0048598
name: embryonic morphogenesis
namespace: biological_process
def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: BFO:0000050 GO:0009790 ! part of embryo development

[Term]
id: GO:0048599
name: oocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]
is_a: GO:0007281 ! germ cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000023 ! results in development of oocyte
relationship: BFO:0000050 GO:0009994 ! part of oocyte differentiation
relationship: RO:0002296 CL:0000023 ! results in development of oocyte

[Term]
id: GO:0048601
name: oocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
synonym: "oocyte morphogenesis during differentiation" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0003006 ! developmental process involved in reproduction
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte
relationship: BFO:0000050 GO:0048599 ! part of oocyte development
relationship: RO:0002298 CL:0000023 ! results in morphogenesis of oocyte

[Term]
id: GO:0048608
name: reproductive structure development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: BFO:0000050 GO:0061458 ! part of reproductive system development

[Term]
id: GO:0048609
name: multicellular organismal reproductive process
namespace: biological_process
def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
synonym: "organismal reproductive process" BROAD []
synonym: "reproductive process in a multicellular organism" EXACT []
xref: Reactome:R-HSA-1474165 "Reproduction"
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0048627
name: myoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000056 ! results in development of myoblast
relationship: BFO:0000050 GO:0045445 ! part of myoblast differentiation
relationship: RO:0002296 CL:0000056 ! results in development of myoblast

[Term]
id: GO:0048628
name: myoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 CL:0000056 ! results in maturation of myoblast
relationship: BFO:0000050 GO:0048627 ! part of myoblast development
relationship: RO:0002299 CL:0000056 ! results in maturation of myoblast

[Term]
id: GO:0048630
name: skeletal muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue
relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development
relationship: RO:0002343 UBERON:0001134 ! results in growth of skeletal muscle tissue

[Term]
id: GO:0048631
name: regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth
relationship: RO:0002211 GO:0048630 ! regulates skeletal muscle tissue growth

[Term]
id: GO:0048632
name: negative regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "down regulation of skeletal muscle growth" EXACT []
synonym: "down-regulation of skeletal muscle growth" EXACT []
synonym: "downregulation of skeletal muscle growth" EXACT []
synonym: "inhibition of skeletal muscle growth" NARROW []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048640 ! negative regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth
relationship: RO:0002212 GO:0048630 ! negatively regulates skeletal muscle tissue growth

[Term]
id: GO:0048633
name: positive regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "activation of skeletal muscle growth" NARROW []
synonym: "stimulation of skeletal muscle growth" NARROW []
synonym: "up regulation of skeletal muscle growth" EXACT []
synonym: "up-regulation of skeletal muscle growth" EXACT []
synonym: "upregulation of skeletal muscle growth" EXACT []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth
relationship: RO:0002213 GO:0048630 ! positively regulates skeletal muscle tissue growth

[Term]
id: GO:0048634
name: regulation of muscle organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007517 ! regulates muscle organ development
relationship: RO:0002211 GO:0007517 ! regulates muscle organ development

[Term]
id: GO:0048635
name: negative regulation of muscle organ development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators]
synonym: "down regulation of muscle development" EXACT []
synonym: "down-regulation of muscle development" EXACT []
synonym: "downregulation of muscle development" EXACT []
synonym: "inhibition of muscle development" NARROW []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007517 ! negatively regulates muscle organ development
relationship: RO:0002212 GO:0007517 ! negatively regulates muscle organ development

[Term]
id: GO:0048636
name: positive regulation of muscle organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
synonym: "activation of muscle development" NARROW []
synonym: "stimulation of muscle development" NARROW []
synonym: "up regulation of muscle development" EXACT []
synonym: "up-regulation of muscle development" EXACT []
synonym: "upregulation of muscle development" EXACT []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007517 ! positively regulates muscle organ development
relationship: RO:0002213 GO:0007517 ! positively regulates muscle organ development

[Term]
id: GO:0048638
name: regulation of developmental growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048589 ! regulates developmental growth
relationship: RO:0002211 GO:0048589 ! regulates developmental growth

[Term]
id: GO:0048639
name: positive regulation of developmental growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators]
synonym: "activation of developmental growth" NARROW []
synonym: "stimulation of developmental growth" NARROW []
synonym: "up regulation of developmental growth" EXACT []
synonym: "up-regulation of developmental growth" EXACT []
synonym: "upregulation of developmental growth" EXACT []
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048589 ! positively regulates developmental growth
relationship: RO:0002213 GO:0048589 ! positively regulates developmental growth

[Term]
id: GO:0048640
name: negative regulation of developmental growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators]
synonym: "down regulation of developmental growth" EXACT []
synonym: "down-regulation of developmental growth" EXACT []
synonym: "downregulation of developmental growth" EXACT []
synonym: "inhibition of developmental growth" NARROW []
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048589 ! negatively regulates developmental growth
relationship: RO:0002212 GO:0048589 ! negatively regulates developmental growth

[Term]
id: GO:0048641
name: regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
is_a: GO:0016202 ! regulation of striated muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development
relationship: RO:0002211 GO:0007519 ! regulates skeletal muscle tissue development

[Term]
id: GO:0048642
name: negative regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
synonym: "down regulation of skeletal muscle development" EXACT []
synonym: "down-regulation of skeletal muscle development" EXACT []
synonym: "downregulation of skeletal muscle development" EXACT []
synonym: "inhibition of skeletal muscle development" NARROW []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development
relationship: RO:0002212 GO:0007519 ! negatively regulates skeletal muscle tissue development

[Term]
id: GO:0048643
name: positive regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators]
synonym: "activation of skeletal muscle development" NARROW []
synonym: "stimulation of skeletal muscle development" NARROW []
synonym: "up regulation of skeletal muscle development" EXACT []
synonym: "up-regulation of skeletal muscle development" EXACT []
synonym: "upregulation of skeletal muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development
relationship: RO:0002213 GO:0007519 ! positively regulates skeletal muscle tissue development

[Term]
id: GO:0048644
name: muscle organ morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ
relationship: BFO:0000050 GO:0007517 ! part of muscle organ development
relationship: RO:0002298 UBERON:0001630 ! results in morphogenesis of muscle organ

[Term]
id: GO:0048645
name: animal organ formation
namespace: biological_process
def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid]
synonym: "animal organ primordium initiation" NARROW []
synonym: "initiation of an animal organ primordium" NARROW []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0003103 ! results in formation of compound organ
relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis
relationship: RO:0002297 UBERON:0003103 ! results in formation of compound organ

[Term]
id: GO:0048646
name: anatomical structure formation involved in morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.
subset: goslim_chembl
synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis

[Term]
id: GO:0048659
name: smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698]
synonym: "SMC proliferation" EXACT []
is_a: GO:0033002 ! muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell
relationship: RO:0012003 CL:0000192 ! acts on population of smooth muscle cell

[Term]
id: GO:0048660
name: regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "regulation of SMC proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation
relationship: RO:0002211 GO:0048659 ! regulates smooth muscle cell proliferation

[Term]
id: GO:0048661
name: positive regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "activation of smooth muscle cell proliferation" NARROW []
synonym: "positive regulation of SMC proliferation" EXACT []
synonym: "stimulation of smooth muscle cell proliferation" NARROW []
synonym: "up regulation of smooth muscle cell proliferation" EXACT []
synonym: "up-regulation of smooth muscle cell proliferation" EXACT []
synonym: "upregulation of smooth muscle cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation
relationship: RO:0002213 GO:0048659 ! positively regulates smooth muscle cell proliferation

[Term]
id: GO:0048662
name: negative regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "down regulation of smooth muscle cell proliferation" EXACT []
synonym: "down-regulation of smooth muscle cell proliferation" EXACT []
synonym: "downregulation of smooth muscle cell proliferation" EXACT []
synonym: "inhibition of smooth muscle cell proliferation" NARROW []
synonym: "negative regulation of SMC proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation
relationship: RO:0002212 GO:0048659 ! negatively regulates smooth muscle cell proliferation

[Term]
id: GO:0048666
name: neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000540 ! results in development of neuron
relationship: BFO:0000050 GO:0030182 ! part of neuron differentiation
relationship: RO:0002296 CL:0000540 ! results in development of neuron

[Term]
id: GO:0048667
name: cell morphogenesis involved in neuron differentiation
namespace: biological_process
def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]
synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: BFO:0000050 GO:0030182 ! part of neuron differentiation
relationship: BFO:0000050 GO:0048666 ! part of neuron development

[Term]
id: GO:0048699
name: generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]
synonym: "neuron generation" EXACT []
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0048705
name: skeletal system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]
synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system
relationship: BFO:0000050 GO:0001501 ! part of skeletal system development
relationship: RO:0002298 UBERON:0001434 ! results in morphogenesis of skeletal system

[Term]
id: GO:0048708
name: astrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000127 ! results in acquisition of features of astrocyte
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002315 CL:0000127 ! results in acquisition of features of astrocyte

[Term]
id: GO:0048709
name: oligodendrocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000128 ! results in acquisition of features of oligodendrocyte
relationship: BFO:0000050 GO:0007417 ! part of central nervous system development
relationship: RO:0002315 CL:0000128 ! results in acquisition of features of oligodendrocyte

[Term]
id: GO:0048710
name: regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048708 ! regulates astrocyte differentiation
relationship: RO:0002211 GO:0048708 ! regulates astrocyte differentiation

[Term]
id: GO:0048711
name: positive regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of astrocyte differentiation" NARROW []
synonym: "stimulation of astrocyte differentiation" NARROW []
synonym: "up regulation of astrocyte differentiation" EXACT []
synonym: "up-regulation of astrocyte differentiation" EXACT []
synonym: "upregulation of astrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048708 ! positively regulates astrocyte differentiation
relationship: RO:0002213 GO:0048708 ! positively regulates astrocyte differentiation

[Term]
id: GO:0048712
name: negative regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of astrocyte differentiation" EXACT []
synonym: "down-regulation of astrocyte differentiation" EXACT []
synonym: "downregulation of astrocyte differentiation" EXACT []
synonym: "inhibition of astrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048708 ! negatively regulates astrocyte differentiation
relationship: RO:0002212 GO:0048708 ! negatively regulates astrocyte differentiation

[Term]
id: GO:0048713
name: regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048709 ! regulates oligodendrocyte differentiation
relationship: RO:0002211 GO:0048709 ! regulates oligodendrocyte differentiation

[Term]
id: GO:0048714
name: positive regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of oligodendrocyte differentiation" NARROW []
synonym: "stimulation of oligodendrocyte differentiation" NARROW []
synonym: "up regulation of oligodendrocyte differentiation" EXACT []
synonym: "up-regulation of oligodendrocyte differentiation" EXACT []
synonym: "upregulation of oligodendrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048709 ! positively regulates oligodendrocyte differentiation
relationship: RO:0002213 GO:0048709 ! positively regulates oligodendrocyte differentiation

[Term]
id: GO:0048715
name: negative regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of oligodendrocyte differentiation" EXACT []
synonym: "down-regulation of oligodendrocyte differentiation" EXACT []
synonym: "downregulation of oligodendrocyte differentiation" EXACT []
synonym: "inhibition of oligodendrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048709 ! negatively regulates oligodendrocyte differentiation
relationship: RO:0002212 GO:0048709 ! negatively regulates oligodendrocyte differentiation

[Term]
id: GO:0048729
name: tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue
relationship: BFO:0000050 GO:0009888 ! part of tissue development
relationship: RO:0002298 UBERON:0000479 ! results in morphogenesis of tissue

[Term]
id: GO:0048730
name: epidermis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003]
synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium
relationship: BFO:0000050 GO:0008544 ! part of epidermis development
relationship: RO:0002298 UBERON:0007376 ! results in morphogenesis of outer epithelium

[Term]
id: GO:0048731
name: system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]
subset: goslim_mouse
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000467 ! results in development of anatomical system
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development
relationship: RO:0002296 UBERON:0000467 ! results in development of anatomical system

[Term]
id: GO:0048732
name: gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002530 ! results in development of gland
relationship: RO:0002296 UBERON:0002530 ! results in development of gland

[Term]
id: GO:0048736
name: appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000026 ! results in development of appendage
relationship: BFO:0000050 GO:0007275 ! part of multicellular organism development
relationship: RO:0002296 UBERON:0000026 ! results in development of appendage

[Term]
id: GO:0048738
name: cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
synonym: "heart muscle development" EXACT []
is_a: GO:0014706 ! striated muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0001133 ! results in development of cardiac muscle tissue

[Term]
id: GO:0048741
name: skeletal muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "skeletal muscle fibre development" EXACT []
synonym: "skeletal myofiber development" EXACT []
synonym: "skeletal myofibre development" EXACT []
is_a: GO:0014904 ! myotube cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber
relationship: BFO:0000050 GO:0007519 ! part of skeletal muscle tissue development
relationship: RO:0002296 CL:0008002 ! results in development of skeletal muscle fiber

[Term]
id: GO:0048742
name: regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]
synonym: "regulation of skeletal muscle fibre development" EXACT []
synonym: "regulation of skeletal myofiber development" EXACT []
synonym: "regulation of skeletal myofibre development" EXACT []
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development
relationship: RO:0002211 GO:0048741 ! regulates skeletal muscle fiber development

[Term]
id: GO:0048743
name: positive regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "activation of skeletal muscle fiber development" NARROW []
synonym: "positive regulation of skeletal muscle fibre development" EXACT []
synonym: "positive regulation of skeletal myofiber development" EXACT []
synonym: "positive regulation of skeletal myofibre development" EXACT []
synonym: "stimulation of skeletal muscle fiber development" NARROW []
synonym: "up regulation of skeletal muscle fiber development" EXACT []
synonym: "up-regulation of skeletal muscle fiber development" EXACT []
synonym: "upregulation of skeletal muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development
relationship: RO:0002213 GO:0048741 ! positively regulates skeletal muscle fiber development

[Term]
id: GO:0048744
name: negative regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "down regulation of skeletal muscle fiber development" EXACT []
synonym: "down-regulation of skeletal muscle fiber development" EXACT []
synonym: "downregulation of skeletal muscle fiber development" EXACT []
synonym: "inhibition of skeletal muscle fiber development" NARROW []
synonym: "negative regulation of skeletal muscle fibre development" EXACT []
synonym: "negative regulation of skeletal myofiber development" EXACT []
synonym: "negative regulation of skeletal myofibre development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development
relationship: RO:0002212 GO:0048741 ! negatively regulates skeletal muscle fiber development

[Term]
id: GO:0048745
name: smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0060537 ! muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue
relationship: RO:0002296 UBERON:0001135 ! results in development of smooth muscle tissue

[Term]
id: GO:0048749
name: compound eye development
namespace: biological_process
def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
synonym: "insect-type retina development" EXACT [PMID:11735386]
is_a: GO:0001654 ! eye development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000018 ! results in development of compound eye
relationship: RO:0002296 UBERON:0000018 ! results in development of compound eye

[Term]
id: GO:0048753
name: pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]
subset: goslim_pir
synonym: "pigment granule organisation" EXACT []
synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0048770 ! results in organization of pigment granule
relationship: BFO:0000050 GO:0033059 ! part of cellular pigmentation
relationship: RO:0002592 GO:0048770 ! results in organization of pigment granule

[Term]
id: GO:0048754
name: branching morphogenesis of an epithelial tube
namespace: biological_process
def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: RO:0002298 UBERON:0000025 ! results in morphogenesis of tube
relationship: BFO:0000050 GO:0060562 ! part of epithelial tube morphogenesis

[Term]
id: GO:0048755
name: branching morphogenesis of a nerve
namespace: biological_process
def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001763 ! morphogenesis of a branching structure
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002298 UBERON:0001021 ! results in morphogenesis of nerve

[Term]
id: GO:0048762
name: mesenchymal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell
relationship: BFO:0000050 GO:0060485 ! part of mesenchyme development
relationship: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell

[Term]
id: GO:0048770
name: pigment granule
namespace: cellular_component
def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0048771
name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0048799
name: animal organ maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0000062 ! results in maturation of organ
relationship: BFO:0000050 GO:0048513 ! part of animal organ development
relationship: RO:0002299 UBERON:0000062 ! results in maturation of organ

[Term]
id: GO:0048806
name: genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
synonym: "genital development" EXACT []
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
relationship: BFO:0000050 GO:0007548 ! part of sex differentiation

[Term]
id: GO:0048812
name: neuron projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection
relationship: BFO:0000050 GO:0031175 ! part of neuron projection development
relationship: RO:0002298 GO:0043005 ! results in morphogenesis of neuron projection

[Term]
id: GO:0048813
name: dendrite morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a dendrite are generated and organized." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]
is_a: GO:0048812 ! neuron projection morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 GO:0030425 ! results in morphogenesis of dendrite
relationship: BFO:0000050 GO:0016358 ! part of dendrite development
relationship: BFO:0000050 GO:0048667 ! part of cell morphogenesis involved in neuron differentiation
relationship: RO:0002298 GO:0030425 ! results in morphogenesis of dendrite

[Term]
id: GO:0048814
name: regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0050773 ! regulation of dendrite development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048813 ! regulates dendrite morphogenesis
relationship: RO:0002211 GO:0048813 ! regulates dendrite morphogenesis

[Term]
id: GO:0048821
name: erythrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol]
synonym: "RBC development" EXACT [CL:0000232]
synonym: "red blood cell development" EXACT [CL:0000232]
is_a: GO:0061515 ! myeloid cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000232 ! results in development of erythrocyte
relationship: BFO:0000050 GO:0030218 ! part of erythrocyte differentiation
relationship: RO:0002296 CL:0000232 ! results in development of erythrocyte

[Term]
id: GO:0048823
name: nucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "nucleate RBC development" EXACT [CL:0000232]
synonym: "nucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte
relationship: BFO:0000050 GO:0043363 ! part of nucleate erythrocyte differentiation
relationship: RO:0002296 CL:0000562 ! results in development of nucleate erythrocyte

[Term]
id: GO:0048844
name: artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480]
synonym: "arterial morphogenesis" EXACT []
synonym: "arteriogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery
relationship: BFO:0000050 GO:0060840 ! part of artery development
relationship: RO:0002298 UBERON:0001637 ! results in morphogenesis of artery

[Term]
id: GO:0048845
name: venous blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480]
synonym: "vein morphogenesis" BROAD []
synonym: "venous morphogenesis" EXACT []
is_a: GO:0048514 ! blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein
relationship: BFO:0000050 GO:0060841 ! part of venous blood vessel development
relationship: RO:0002298 UBERON:0001638 ! results in morphogenesis of vein

[Term]
id: GO:0048847
name: adenohypophysis formation
namespace: biological_process
def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis biosynthesis" EXACT []
synonym: "adenophysis formation" EXACT []
synonym: "anterior pituitary biosynthesis" EXACT []
synonym: "anterior pituitary formation" EXACT []
synonym: "anterior pituitary gland biosynthesis" EXACT []
synonym: "anterior pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002196 ! results in formation of adenohypophysis
relationship: BFO:0000050 GO:0048855 ! part of adenohypophysis morphogenesis
relationship: RO:0002297 UBERON:0002196 ! results in formation of adenohypophysis

[Term]
id: GO:0048848
name: neurohypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis morphogenesis" EXACT []
synonym: "posterior pituitary gland morphogenesis" EXACT []
synonym: "posterior pituitary morphogenesis" EXACT []
is_a: GO:0022612 ! gland morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002198 ! results in morphogenesis of neurohypophysis
relationship: BFO:0000050 GO:0021985 ! part of neurohypophysis development
relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis
relationship: RO:0002298 UBERON:0002198 ! results in morphogenesis of neurohypophysis

[Term]
id: GO:0048849
name: neurohypophysis formation
namespace: biological_process
def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neurophysis biosynthesis" EXACT []
synonym: "neurophysis formation" EXACT []
synonym: "posterior pituitary biosynthesis" EXACT []
synonym: "posterior pituitary formation" EXACT []
synonym: "posterior pituitary gland biosynthesis" EXACT []
synonym: "posterior pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002198 ! results in formation of neurohypophysis
relationship: BFO:0000050 GO:0048848 ! part of neurohypophysis morphogenesis
relationship: RO:0002297 UBERON:0002198 ! results in formation of neurohypophysis

[Term]
id: GO:0048850
name: hypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "pituitary gland morphogenesis" EXACT []
is_a: GO:0022612 ! gland morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000007 ! results in morphogenesis of pituitary gland
relationship: BFO:0000050 GO:0021983 ! part of pituitary gland development
relationship: BFO:0000050 GO:0048852 ! part of diencephalon morphogenesis
relationship: RO:0002298 UBERON:0000007 ! results in morphogenesis of pituitary gland

[Term]
id: GO:0048851
name: hypophysis formation
namespace: biological_process
def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "hypophysis biosynthesis" EXACT []
synonym: "pituitary gland biosynthesis" EXACT []
synonym: "pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000007 ! results in formation of pituitary gland
relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis
relationship: RO:0002297 UBERON:0000007 ! results in formation of pituitary gland

[Term]
id: GO:0048852
name: diencephalon morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001894 ! results in morphogenesis of diencephalon
relationship: BFO:0000050 GO:0021536 ! part of diencephalon development
relationship: BFO:0000050 GO:0048853 ! part of forebrain morphogenesis
relationship: RO:0002298 UBERON:0001894 ! results in morphogenesis of diencephalon

[Term]
id: GO:0048853
name: forebrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "prosencephalon morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001890 ! results in morphogenesis of forebrain
relationship: BFO:0000050 GO:0030900 ! part of forebrain development
relationship: BFO:0000050 GO:0048854 ! part of brain morphogenesis
relationship: RO:0002298 UBERON:0001890 ! results in morphogenesis of forebrain

[Term]
id: GO:0048854
name: brain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain
relationship: BFO:0000050 GO:0007420 ! part of brain development
relationship: RO:0002298 UBERON:0000955 ! results in morphogenesis of brain

[Term]
id: GO:0048855
name: adenohypophysis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]
synonym: "adenophysis morphogenesis" EXACT []
synonym: "anterior pituitary gland morphogenesis" EXACT []
synonym: "anterior pituitary morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002196 ! results in morphogenesis of adenohypophysis
relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development
relationship: BFO:0000050 GO:0048850 ! part of hypophysis morphogenesis
relationship: RO:0002298 UBERON:0002196 ! results in morphogenesis of adenohypophysis

[Term]
id: GO:0048856
name: anatomical structure development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
subset: goslim_plant_ribbon
synonym: "development of an anatomical structure" EXACT []
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 UBERON:0000061 ! results in development of anatomical structure
relationship: RO:0002296 UBERON:0000061 ! results in development of anatomical structure

[Term]
id: GO:0048857
name: neural nucleus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000125 ! results in development of neural nucleus
relationship: RO:0002296 UBERON:0000125 ! results in development of neural nucleus

[Term]
id: GO:0048858
name: cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0030030 ! cell projection organization
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection
relationship: BFO:0000050 GO:0000902 ! part of cell morphogenesis
relationship: RO:0002298 GO:0042995 ! results in morphogenesis of cell projection

[Term]
id: GO:0048859
name: formation of anatomical boundary
namespace: biological_process
def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0007651 ! results in formation of anatomical junction
relationship: RO:0002297 UBERON:0007651 ! results in formation of anatomical junction

[Term]
id: GO:0048860
name: glioblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol]
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000030 ! has primary input glioblast
relationship: RO:0004009 CL:0000030 ! has primary input glioblast

[Term]
id: GO:0048863
name: stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
xref: Wikipedia:Stem_cell_differentiation
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell
relationship: RO:0002315 CL:0000034 ! results in acquisition of features of stem cell

[Term]
id: GO:0048864
name: stem cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000034 ! results in development of stem cell
relationship: BFO:0000050 GO:0048863 ! part of stem cell differentiation
relationship: RO:0002296 CL:0000034 ! results in development of stem cell

[Term]
id: GO:0048869
name: cellular developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]
is_a: GO:0009987 ! cellular process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048870
name: cell motility
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_prokaryote
synonym: "cell locomotion" EXACT []
synonym: "cell movement" RELATED []
synonym: "movement of a cell" EXACT []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0048871
name: multicellular organismal-level homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048872
name: homeostasis of number of cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]
synonym: "cell population homeostasis" EXACT []
synonym: "homeostasis of cell number" EXACT [GOC:dph]
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0048873
name: homeostasis of number of cells within a tissue
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete]
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0048880
name: sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001032 ! results in development of sensory system
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 UBERON:0001032 ! results in development of sensory system

[Term]
id: GO:0048934
name: peripheral nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron
relationship: BFO:0000050 GO:0007422 ! part of peripheral nervous system development
relationship: RO:0002315 CL:2000032 ! results in acquisition of features of peripheral nervous system neuron

[Term]
id: GO:0048935
name: peripheral nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron
relationship: BFO:0000050 GO:0048934 ! part of peripheral nervous system neuron differentiation
relationship: RO:0002296 CL:2000032 ! results in development of peripheral nervous system neuron

[Term]
id: GO:0050000
name: chromosome localization
namespace: biological_process
def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "chromosome localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chromosome localization" EXACT []
synonym: "establishment and maintenance of chromosome position" EXACT []
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005694 ! has primary input chromosome
relationship: RO:0004009 GO:0005694 ! has primary input chromosome

[Term]
id: GO:0050432
name: catecholamine secretion
namespace: biological_process
def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef]
is_a: GO:0032940 ! secretion by cell
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:33567 ! has primary input

[Term]
id: GO:0050433
name: regulation of catecholamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai]
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050432 ! regulates catecholamine secretion
relationship: RO:0002211 GO:0050432 ! regulates catecholamine secretion

[Term]
id: GO:0050657
name: nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
is_a: GO:0015931 ! nucleobase-containing compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid

[Term]
id: GO:0050658
name: RNA transport
namespace: biological_process
def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
is_a: GO:0051236 ! establishment of RNA localization
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid

[Term]
id: GO:0050670
name: regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai]
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046651 ! regulates lymphocyte proliferation
relationship: RO:0002211 GO:0046651 ! regulates lymphocyte proliferation

[Term]
id: GO:0050671
name: positive regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "activation of lymphocyte proliferation" NARROW []
synonym: "stimulation of lymphocyte proliferation" NARROW []
synonym: "up regulation of lymphocyte proliferation" EXACT []
synonym: "up-regulation of lymphocyte proliferation" EXACT []
synonym: "upregulation of lymphocyte proliferation" EXACT []
is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046651 ! positively regulates lymphocyte proliferation
relationship: RO:0002213 GO:0046651 ! positively regulates lymphocyte proliferation

[Term]
id: GO:0050672
name: negative regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "down regulation of lymphocyte proliferation" EXACT []
synonym: "down-regulation of lymphocyte proliferation" EXACT []
synonym: "downregulation of lymphocyte proliferation" EXACT []
synonym: "inhibition of lymphocyte proliferation" NARROW []
is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046651 ! negatively regulates lymphocyte proliferation
relationship: RO:0002212 GO:0046651 ! negatively regulates lymphocyte proliferation

[Term]
id: GO:0050673
name: epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000066 ! acts on population of epithelial cell
relationship: RO:0012003 CL:0000066 ! acts on population of epithelial cell

[Term]
id: GO:0050678
name: regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation
relationship: RO:0002211 GO:0050673 ! regulates epithelial cell proliferation

[Term]
id: GO:0050679
name: positive regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "activation of epithelial cell proliferation" NARROW []
synonym: "stimulation of epithelial cell proliferation" NARROW []
synonym: "up regulation of epithelial cell proliferation" EXACT []
synonym: "up-regulation of epithelial cell proliferation" EXACT []
synonym: "upregulation of epithelial cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation
relationship: RO:0002213 GO:0050673 ! positively regulates epithelial cell proliferation

[Term]
id: GO:0050680
name: negative regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "down regulation of epithelial cell proliferation" EXACT []
synonym: "down-regulation of epithelial cell proliferation" EXACT []
synonym: "downregulation of epithelial cell proliferation" EXACT []
synonym: "inhibition of epithelial cell proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation
relationship: RO:0002212 GO:0050673 ! negatively regulates epithelial cell proliferation

[Term]
id: GO:0050708
name: regulation of protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009306 ! regulates protein secretion
relationship: RO:0002211 GO:0009306 ! regulates protein secretion

[Term]
id: GO:0050709
name: negative regulation of protein secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "down regulation of protein secretion" EXACT []
synonym: "down-regulation of protein secretion" EXACT []
synonym: "downregulation of protein secretion" EXACT []
synonym: "inhibition of protein secretion" NARROW []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009306 ! negatively regulates protein secretion
relationship: RO:0002212 GO:0009306 ! negatively regulates protein secretion

[Term]
id: GO:0050714
name: positive regulation of protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "activation of protein secretion" NARROW []
synonym: "stimulation of protein secretion" NARROW []
synonym: "up regulation of protein secretion" EXACT []
synonym: "up-regulation of protein secretion" EXACT []
synonym: "upregulation of protein secretion" EXACT []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009306 ! positively regulates protein secretion
relationship: RO:0002213 GO:0009306 ! positively regulates protein secretion

[Term]
id: GO:0050727
name: regulation of inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006954 ! regulates inflammatory response
relationship: RO:0002211 GO:0006954 ! regulates inflammatory response

[Term]
id: GO:0050728
name: negative regulation of inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "anti-inflammatory response" EXACT []
synonym: "down regulation of inflammatory response" EXACT []
synonym: "down-regulation of inflammatory response" EXACT []
synonym: "downregulation of inflammatory response" EXACT []
synonym: "inhibition of inflammatory response" NARROW []
xref: Reactome:R-HSA-9018678 "Biosynthesis of specialized proresolving mediators (SPMs)"
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006954 ! negatively regulates inflammatory response
relationship: RO:0002212 GO:0006954 ! negatively regulates inflammatory response

[Term]
id: GO:0050729
name: positive regulation of inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "activation of inflammatory response" NARROW []
synonym: "stimulation of inflammatory response" NARROW []
synonym: "up regulation of inflammatory response" EXACT []
synonym: "up-regulation of inflammatory response" EXACT []
synonym: "upregulation of inflammatory response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006954 ! positively regulates inflammatory response
relationship: RO:0002213 GO:0006954 ! positively regulates inflammatory response

[Term]
id: GO:0050764
name: regulation of phagocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]
is_a: GO:0030100 ! regulation of endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006909 ! regulates phagocytosis
relationship: RO:0002211 GO:0006909 ! regulates phagocytosis

[Term]
id: GO:0050765
name: negative regulation of phagocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "down regulation of phagocytosis" EXACT []
synonym: "down-regulation of phagocytosis" EXACT []
synonym: "downregulation of phagocytosis" EXACT []
synonym: "inhibition of phagocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006909 ! negatively regulates phagocytosis
relationship: RO:0002212 GO:0006909 ! negatively regulates phagocytosis

[Term]
id: GO:0050766
name: positive regulation of phagocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "activation of phagocytosis" NARROW []
synonym: "stimulation of phagocytosis" NARROW []
synonym: "up regulation of phagocytosis" EXACT []
synonym: "up-regulation of phagocytosis" EXACT []
synonym: "upregulation of phagocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006909 ! positively regulates phagocytosis
relationship: RO:0002213 GO:0006909 ! positively regulates phagocytosis

[Term]
id: GO:0050767
name: regulation of neurogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022008 ! regulates neurogenesis
relationship: RO:0002211 GO:0022008 ! regulates neurogenesis

[Term]
id: GO:0050768
name: negative regulation of neurogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]
synonym: "down regulation of neurogenesis" EXACT []
synonym: "down-regulation of neurogenesis" EXACT []
synonym: "downregulation of neurogenesis" EXACT []
synonym: "inhibition of neurogenesis" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051961 ! negative regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0022008 ! negatively regulates neurogenesis
relationship: RO:0002212 GO:0022008 ! negatively regulates neurogenesis

[Term]
id: GO:0050769
name: positive regulation of neurogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]
synonym: "activation of neurogenesis" NARROW []
synonym: "stimulation of neurogenesis" NARROW []
synonym: "up regulation of neurogenesis" EXACT []
synonym: "up-regulation of neurogenesis" EXACT []
synonym: "upregulation of neurogenesis" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051962 ! positive regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0022008 ! positively regulates neurogenesis
relationship: RO:0002213 GO:0022008 ! positively regulates neurogenesis

[Term]
id: GO:0050770
name: regulation of axonogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
xref: Reactome:R-HSA-193697 "p75NTR regulates axonogenesis"
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007409 ! regulates axonogenesis
relationship: RO:0002211 GO:0007409 ! regulates axonogenesis

[Term]
id: GO:0050771
name: negative regulation of axonogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "down regulation of axonogenesis" EXACT []
synonym: "down-regulation of axonogenesis" EXACT []
synonym: "downregulation of axonogenesis" EXACT []
synonym: "inhibition of axonogenesis" NARROW []
xref: Reactome:R-HSA-193634 "Axonal growth inhibition (RHOA activation)"
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:0050770 ! regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007409 ! negatively regulates axonogenesis
relationship: RO:0002212 GO:0007409 ! negatively regulates axonogenesis

[Term]
id: GO:0050772
name: positive regulation of axonogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "activation of axonogenesis" NARROW []
synonym: "stimulation of axonogenesis" NARROW []
synonym: "up regulation of axonogenesis" EXACT []
synonym: "up-regulation of axonogenesis" EXACT []
synonym: "upregulation of axonogenesis" EXACT []
xref: Reactome:R-HSA-209563 "Axonal growth stimulation"
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:0050770 ! regulation of axonogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007409 ! positively regulates axonogenesis
relationship: RO:0002213 GO:0007409 ! positively regulates axonogenesis

[Term]
id: GO:0050773
name: regulation of dendrite development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016358 ! regulates dendrite development
relationship: RO:0002211 GO:0016358 ! regulates dendrite development

[Term]
id: GO:0050774
name: negative regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "down regulation of dendrite morphogenesis" EXACT []
synonym: "down-regulation of dendrite morphogenesis" EXACT []
synonym: "downregulation of dendrite morphogenesis" EXACT []
synonym: "inhibition of dendrite morphogenesis" NARROW []
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048813 ! negatively regulates dendrite morphogenesis
relationship: RO:0002212 GO:0048813 ! negatively regulates dendrite morphogenesis

[Term]
id: GO:0050775
name: positive regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "activation of dendrite morphogenesis" NARROW []
synonym: "stimulation of dendrite morphogenesis" NARROW []
synonym: "up regulation of dendrite morphogenesis" EXACT []
synonym: "up-regulation of dendrite morphogenesis" EXACT []
synonym: "upregulation of dendrite morphogenesis" EXACT []
is_a: GO:0010770 ! positive regulation of cell morphogenesis
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048813 ! positively regulates dendrite morphogenesis
relationship: RO:0002213 GO:0048813 ! positively regulates dendrite morphogenesis

[Term]
id: GO:0050776
name: regulation of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
xref: Reactome:R-HSA-198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006955 ! regulates immune response
relationship: RO:0002211 GO:0006955 ! regulates immune response

[Term]
id: GO:0050777
name: negative regulation of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "down regulation of immune response" EXACT []
synonym: "down-regulation of immune response" EXACT []
synonym: "downregulation of immune response" EXACT []
synonym: "inhibition of immune response" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006955 ! negatively regulates immune response
relationship: RO:0002212 GO:0006955 ! negatively regulates immune response

[Term]
id: GO:0050778
name: positive regulation of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "stimulation of immune response" NARROW []
synonym: "up regulation of immune response" EXACT []
synonym: "up-regulation of immune response" EXACT []
synonym: "upregulation of immune response" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006955 ! positively regulates immune response
relationship: RO:0002213 GO:0006955 ! positively regulates immune response

[Term]
id: GO:0050789
name: regulation of biological process
namespace: biological_process
alt_id: GO:0050791
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "regulation of physiological process" EXACT []
is_a: GO:0065007 ! biological regulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008150 ! regulates biological_process
relationship: RO:0002211 GO:0008150 ! regulates biological_process

[Term]
id: GO:0050790
name: regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048552
def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]
subset: gocheck_obsoletion_candidate
subset: goslim_chembl
synonym: "regulation of enzyme activity" EXACT []
synonym: "regulation of metalloenzyme activity" NARROW []
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003824 ! regulates catalytic activity
relationship: RO:0002211 GO:0003824 ! regulates catalytic activity

[Term]
id: GO:0050793
name: regulation of developmental process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032502 ! regulates developmental process
relationship: RO:0002211 GO:0032502 ! regulates developmental process

[Term]
id: GO:0050794
name: regulation of cellular process
namespace: biological_process
alt_id: GO:0051244
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "regulation of cellular physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009987 ! regulates cellular process
relationship: RO:0002211 GO:0009987 ! regulates cellular process

[Term]
id: GO:0050795
name: regulation of behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]
synonym: "regulation of behaviour" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007610 ! regulates behavior
relationship: RO:0002211 GO:0007610 ! regulates behavior

[Term]
id: GO:0050803
name: regulation of synapse structure or activity
namespace: biological_process
def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
is_a: GO:0065008 ! regulation of biological quality
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa

[Term]
id: GO:0050804
name: modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]
subset: goslim_synapse
synonym: "modulation of synaptic transmission" BROAD []
synonym: "regulation of chemical synaptic transmission" EXACT []
synonym: "regulation of synaptic transmission" EXACT []
is_a: GO:0099177 ! regulation of trans-synaptic signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0050805
name: negative regulation of synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "down regulation of synaptic transmission" EXACT []
synonym: "down-regulation of synaptic transmission" EXACT []
synonym: "downregulation of synaptic transmission" EXACT []
synonym: "inhibition of synaptic transmission" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission
relationship: RO:0002212 GO:0007268 ! negatively regulates chemical synaptic transmission

[Term]
id: GO:0050806
name: positive regulation of synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "activation of synaptic transmission" NARROW []
synonym: "stimulation of synaptic transmission" NARROW []
synonym: "up regulation of synaptic transmission" EXACT []
synonym: "up-regulation of synaptic transmission" EXACT []
synonym: "upregulation of synaptic transmission" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission
relationship: RO:0002213 GO:0007268 ! positively regulates chemical synaptic transmission

[Term]
id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of synapse organisation" EXACT [GOC:mah]
synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of synapse structure" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050808 ! regulates synapse organization
relationship: BFO:0000050 GO:0050803 ! part of regulation of synapse structure or activity
relationship: RO:0002211 GO:0050808 ! regulates synapse organization

[Term]
id: GO:0050808
name: synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
subset: goslim_drosophila
subset: goslim_synapse
synonym: "synapse development" RELATED [GOC:aruk]
synonym: "synapse morphogenesis" RELATED [GOC:BHF]
synonym: "synapse organisation" EXACT []
synonym: "synapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002592 GO:0045202 ! results in organization of synapse
relationship: RO:0002592 GO:0045202 ! results in organization of synapse

[Term]
id: GO:0050810
name: regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]
synonym: "regulation of steroid anabolism" EXACT []
synonym: "regulation of steroid biosynthesis" EXACT []
synonym: "regulation of steroid formation" EXACT []
synonym: "regulation of steroid synthesis" EXACT []
synonym: "regulation of steroidogenesis" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process
relationship: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process

[Term]
id: GO:0050832
name: defense response to fungus
namespace: biological_process
def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to fungi" EXACT []
synonym: "defence response to fungus" EXACT []
synonym: "defense response to fungi" EXACT []
synonym: "defense response to fungus, incompatible interaction" NARROW []
synonym: "resistance response to pathogenic fungi" NARROW []
synonym: "resistance response to pathogenic fungus" NARROW []
synonym: "response to parasitic fungi" NARROW []
synonym: "response to parasitic fungus" NARROW []
is_a: GO:0006952 ! defense response
is_a: GO:0009620 ! response to fungus
intersection_of: GO:0006952 ! defense response
intersection_of: RO:0004009 NCBITaxon:4751 ! has primary input Fungi

[Term]
id: GO:0050839
name: cell adhesion molecule binding
namespace: molecular_function
def: "Binding to a cell adhesion molecule." [GOC:ai]
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "CAM binding" EXACT []
synonym: "cell adhesion molecule activity" RELATED []
synonym: "cell adhesion receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0050840
name: extracellular matrix binding
namespace: molecular_function
def: "Binding to a component of the extracellular matrix." [GOC:ai]
subset: goslim_chembl
subset: goslim_pir
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "extracellular matrix constituent binding" EXACT []
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0031012 ! has primary input extracellular matrix
relationship: RO:0004009 GO:0031012 ! has primary input extracellular matrix

[Term]
id: GO:0050863
name: regulation of T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "regulation of T lymphocyte activation" EXACT []
synonym: "regulation of T-cell activation" EXACT []
synonym: "regulation of T-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042110 ! regulates T cell activation
relationship: RO:0002211 GO:0042110 ! regulates T cell activation

[Term]
id: GO:0050865
name: regulation of cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001775 ! regulates cell activation
relationship: RO:0002211 GO:0001775 ! regulates cell activation

[Term]
id: GO:0050866
name: negative regulation of cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai]
synonym: "down regulation of cell activation" EXACT []
synonym: "down-regulation of cell activation" EXACT []
synonym: "downregulation of cell activation" EXACT []
synonym: "inhibition of cell activation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001775 ! negatively regulates cell activation
relationship: RO:0002212 GO:0001775 ! negatively regulates cell activation

[Term]
id: GO:0050867
name: positive regulation of cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai]
synonym: "activation of cell activation" NARROW []
synonym: "stimulation of cell activation" NARROW []
synonym: "up regulation of cell activation" EXACT []
synonym: "up-regulation of cell activation" EXACT []
synonym: "upregulation of cell activation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001775 ! positively regulates cell activation
relationship: RO:0002213 GO:0001775 ! positively regulates cell activation

[Term]
id: GO:0050868
name: negative regulation of T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "down regulation of T cell activation" EXACT []
synonym: "down-regulation of T cell activation" EXACT []
synonym: "downregulation of T cell activation" EXACT []
synonym: "inhibition of T cell activation" NARROW []
synonym: "negative regulation of T lymphocyte activation" EXACT []
synonym: "negative regulation of T-cell activation" EXACT []
synonym: "negative regulation of T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042110 ! negatively regulates T cell activation
relationship: RO:0002212 GO:0042110 ! negatively regulates T cell activation

[Term]
id: GO:0050870
name: positive regulation of T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "activation of T cell activation" NARROW []
synonym: "positive regulation of T lymphocyte activation" EXACT []
synonym: "positive regulation of T-cell activation" EXACT []
synonym: "positive regulation of T-lymphocyte activation" EXACT []
synonym: "stimulation of T cell activation" NARROW []
synonym: "up regulation of T cell activation" EXACT []
synonym: "up-regulation of T cell activation" EXACT []
synonym: "upregulation of T cell activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042110 ! positively regulates T cell activation
relationship: RO:0002213 GO:0042110 ! positively regulates T cell activation

[Term]
id: GO:0050877
name: nervous system process
namespace: biological_process
def: "An organ system process carried out by any of the organs or tissues of the neurological system." [GOC:ai, GOC:mtg_cardio]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
synonym: "neurological system process" EXACT []
synonym: "neurophysiological process" EXACT []
synonym: "pan-neural process" RELATED []
is_a: GO:0003008 ! system process
intersection_of: GO:0003008 ! system process
intersection_of: RO:0000057 UBERON:0001016 ! has participant nervous system
relationship: RO:0000057 UBERON:0001016 ! has participant nervous system
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0050878
name: regulation of body fluid levels
namespace: biological_process
def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_pir
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050881
name: musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]
is_a: GO:0050879 ! multicellular organismal movement
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050886
name: endocrine process
namespace: biological_process
def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]
subset: goslim_generic
subset: goslim_pir
synonym: "endocrine physiological process" EXACT []
synonym: "endocrine physiology" EXACT []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050890
name: cognition
namespace: biological_process
def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908]
subset: goslim_drosophila
xref: Wikipedia:Cognition
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
synonym: "physiological response to stimulus" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0050900
name: leukocyte migration
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration" EXACT []
synonym: "immune cell trafficking" EXACT []
synonym: "leucocyte migration" EXACT []
synonym: "leucocyte trafficking" EXACT []
synonym: "leukocyte trafficking" EXACT []
xref: Reactome:R-HSA-202733 "Cell surface interactions at the vascular wall"
is_a: GO:0002376 ! immune system process
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002565 CL:0000738 ! results in movement of leukocyte

[Term]
id: GO:0050905
name: neuromuscular process
namespace: biological_process
def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
synonym: "neuromotor process" EXACT []
synonym: "neuromuscular physiological process" EXACT []
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050906
name: detection of stimulus involved in sensory perception
namespace: biological_process
def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]
synonym: "sensory detection of stimulus" EXACT []
synonym: "sensory perception, sensory transduction of stimulus" EXACT []
synonym: "sensory perception, stimulus detection" EXACT []
synonym: "sensory transduction" EXACT []
xref: Wikipedia:Transduction_(physiology)
is_a: GO:0051606 ! detection of stimulus
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
relationship: BFO:0000050 GO:0007600 ! part of sensory perception

[Term]
id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of chemical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
relationship: BFO:0000050 GO:0007606 ! part of sensory perception of chemical stimulus

[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
namespace: biological_process
def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "sensory detection of light during visual perception" EXACT []
synonym: "sensory detection of light stimulus during visual perception" EXACT []
synonym: "sensory transduction of light during visual perception" EXACT []
synonym: "sensory transduction of light stimulus during visual perception" EXACT []
synonym: "visual perception, detection of light stimulus" EXACT []
synonym: "visual perception, sensory transduction during perception of light" EXACT []
synonym: "visual perception, sensory transduction of light stimulus" EXACT []
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: BFO:0000050 GO:0007601 ! part of visual perception
relationship: BFO:0000050 GO:0007601 ! part of visual perception

[Term]
id: GO:0050909
name: sensory perception of taste
namespace: biological_process
def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai]
synonym: "gustation" EXACT []
synonym: "sense of taste" EXACT []
synonym: "taste" EXACT []
synonym: "taste perception" EXACT []
xref: Reactome:R-HSA-9717189 "Sensory perception of taste"
xref: Wikipedia:Taste
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050912
name: detection of chemical stimulus involved in sensory perception of taste
namespace: biological_process
def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "perception of taste, detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of taste" EXACT []
synonym: "sensory detection of taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT []
synonym: "sensory transduction of taste" EXACT []
synonym: "taste perception" BROAD []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: BFO:0000050 GO:0050909 ! part of sensory perception of taste
relationship: BFO:0000050 GO:0050909 ! part of sensory perception of taste

[Term]
id: GO:0050920
name: regulation of chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0040012 ! regulation of locomotion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006935 ! regulates chemotaxis
relationship: RO:0002211 GO:0006935 ! regulates chemotaxis

[Term]
id: GO:0050921
name: positive regulation of chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
synonym: "activation of chemotaxis" NARROW []
synonym: "stimulation of chemotaxis" NARROW []
synonym: "up regulation of chemotaxis" EXACT []
synonym: "up-regulation of chemotaxis" EXACT []
synonym: "upregulation of chemotaxis" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006935 ! positively regulates chemotaxis
relationship: RO:0002213 GO:0006935 ! positively regulates chemotaxis

[Term]
id: GO:0050922
name: negative regulation of chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
synonym: "down regulation of chemotaxis" EXACT []
synonym: "down-regulation of chemotaxis" EXACT []
synonym: "downregulation of chemotaxis" EXACT []
synonym: "inhibition of chemotaxis" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006935 ! negatively regulates chemotaxis
relationship: RO:0002212 GO:0006935 ! negatively regulates chemotaxis

[Term]
id: GO:0050931
name: pigment cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]
comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
synonym: "chromatophore differentiation" EXACT []
synonym: "pigmented cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell
relationship: BFO:0000050 GO:0048066 ! part of developmental pigmentation
relationship: RO:0002315 CL:0000147 ! results in acquisition of features of pigment cell

[Term]
id: GO:0050932
name: regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050931 ! regulates pigment cell differentiation
relationship: RO:0002211 GO:0050931 ! regulates pigment cell differentiation

[Term]
id: GO:0050941
name: negative regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "down regulation of pigment cell differentiation" EXACT []
synonym: "down-regulation of pigment cell differentiation" EXACT []
synonym: "downregulation of pigment cell differentiation" EXACT []
synonym: "inhibition of pigment cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation
relationship: RO:0002212 GO:0050931 ! negatively regulates pigment cell differentiation

[Term]
id: GO:0050942
name: positive regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "activation of pigment cell differentiation" NARROW []
synonym: "stimulation of pigment cell differentiation" NARROW []
synonym: "up regulation of pigment cell differentiation" EXACT []
synonym: "up-regulation of pigment cell differentiation" EXACT []
synonym: "upregulation of pigment cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation
relationship: RO:0002213 GO:0050931 ! positively regulates pigment cell differentiation

[Term]
id: GO:0050953
name: sensory perception of light stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050954
name: sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanosensory perception" EXACT []
synonym: "perception of mechanical stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050962
name: detection of light stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos]
synonym: "sensory detection of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of light stimulus" EXACT []
synonym: "sensory perception, sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus during sensory perception" EXACT []
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: BFO:0000050 GO:0007600 ! part of sensory perception
relationship: BFO:0000050 GO:0050953 ! part of sensory perception of light stimulus

[Term]
id: GO:0050968
name: detection of chemical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "chemical nociception" RELATED [GOC:pr]
synonym: "perception of pain, detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain

[Term]
id: GO:0050975
name: sensory perception of touch
namespace: biological_process
def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
synonym: "perception of touch" EXACT []
synonym: "tactile sense" EXACT []
synonym: "taction" EXACT []
synonym: "tactition" EXACT []
xref: Wikipedia:Touch
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050994
name: regulation of lipid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "regulation of lipid breakdown" EXACT []
synonym: "regulation of lipid catabolism" EXACT []
synonym: "regulation of lipid degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016042 ! regulates lipid catabolic process
relationship: RO:0002211 GO:0016042 ! regulates lipid catabolic process

[Term]
id: GO:0050995
name: negative regulation of lipid catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "down regulation of lipid catabolic process" EXACT []
synonym: "down-regulation of lipid catabolic process" EXACT []
synonym: "downregulation of lipid catabolic process" EXACT []
synonym: "inhibition of lipid catabolic process" NARROW []
synonym: "negative regulation of lipid breakdown" EXACT []
synonym: "negative regulation of lipid catabolism" EXACT []
synonym: "negative regulation of lipid degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process
relationship: RO:0002212 GO:0016042 ! negatively regulates lipid catabolic process

[Term]
id: GO:0050996
name: positive regulation of lipid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "activation of lipid catabolic process" NARROW []
synonym: "positive regulation of lipid breakdown" EXACT []
synonym: "positive regulation of lipid catabolism" EXACT []
synonym: "positive regulation of lipid degradation" EXACT []
synonym: "stimulation of lipid catabolic process" NARROW []
synonym: "up regulation of lipid catabolic process" EXACT []
synonym: "up-regulation of lipid catabolic process" EXACT []
synonym: "upregulation of lipid catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process
relationship: RO:0002213 GO:0016042 ! positively regulates lipid catabolic process

[Term]
id: GO:0051017
name: actin filament bundle assembly
namespace: biological_process
def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
synonym: "actin bundling activity" RELATED []
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061572 ! actin filament bundle organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle
relationship: RO:0002588 GO:0032432 ! results in assembly of actin filament bundle

[Term]
id: GO:0051027
name: DNA transport
namespace: biological_process
def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:16991 ! has primary input
relationship: RO:0004009 CHEBI:16991 ! has primary input

[Term]
id: GO:0051031
name: tRNA transport
namespace: biological_process
def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:17843 ! has primary input
relationship: RO:0004009 CHEBI:17843 ! has primary input

[Term]
id: GO:0051032
name: nucleic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai]
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
relationship: BFO:0000050 GO:0050657 ! part of nucleic acid transport
relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid

[Term]
id: GO:0051033
name: RNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol"
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
relationship: BFO:0000050 GO:0050658 ! part of RNA transport
relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid

[Term]
id: GO:0051034
name: tRNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051033 ! RNA transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:17843 ! has primary input
relationship: BFO:0000050 GO:0051031 ! part of tRNA transport
relationship: RO:0004009 CHEBI:17843 ! has primary input

[Term]
id: GO:0051035
name: DNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:16991 ! has primary input
relationship: BFO:0000050 GO:0051027 ! part of DNA transport
relationship: RO:0004009 CHEBI:16991 ! has primary input

[Term]
id: GO:0051046
name: regulation of secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046903 ! regulates secretion
relationship: RO:0002211 GO:0046903 ! regulates secretion

[Term]
id: GO:0051047
name: positive regulation of secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "activation of secretion" NARROW []
synonym: "stimulation of secretion" NARROW []
synonym: "up regulation of secretion" EXACT []
synonym: "up-regulation of secretion" EXACT []
synonym: "upregulation of secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046903 ! positively regulates secretion
relationship: RO:0002213 GO:0046903 ! positively regulates secretion

[Term]
id: GO:0051048
name: negative regulation of secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "down regulation of secretion" EXACT []
synonym: "down-regulation of secretion" EXACT []
synonym: "downregulation of secretion" EXACT []
synonym: "inhibition of secretion" NARROW []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046903 ! negatively regulates secretion
relationship: RO:0002212 GO:0046903 ! negatively regulates secretion

[Term]
id: GO:0051049
name: regulation of transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_yeast
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006810 ! regulates transport
relationship: RO:0002211 GO:0006810 ! regulates transport

[Term]
id: GO:0051050
name: positive regulation of transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of transport" NARROW []
synonym: "stimulation of transport" NARROW []
synonym: "up regulation of transport" EXACT []
synonym: "up-regulation of transport" EXACT []
synonym: "upregulation of transport" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006810 ! positively regulates transport
relationship: RO:0002213 GO:0006810 ! positively regulates transport

[Term]
id: GO:0051051
name: negative regulation of transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of transport" EXACT []
synonym: "down-regulation of transport" EXACT []
synonym: "downregulation of transport" EXACT []
synonym: "inhibition of transport" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006810 ! negatively regulates transport
relationship: RO:0002212 GO:0006810 ! negatively regulates transport

[Term]
id: GO:0051052
name: regulation of DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: goslim_yeast
synonym: "regulation of DNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006259 ! regulates DNA metabolic process
relationship: RO:0002211 GO:0006259 ! regulates DNA metabolic process

[Term]
id: GO:0051053
name: negative regulation of DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
synonym: "down regulation of DNA metabolic process" EXACT []
synonym: "down-regulation of DNA metabolic process" EXACT []
synonym: "downregulation of DNA metabolic process" EXACT []
synonym: "inhibition of DNA metabolic process" NARROW []
synonym: "negative regulation of DNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006259 ! negatively regulates DNA metabolic process
relationship: RO:0002212 GO:0006259 ! negatively regulates DNA metabolic process

[Term]
id: GO:0051054
name: positive regulation of DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
synonym: "activation of DNA metabolic process" NARROW []
synonym: "positive regulation of DNA metabolism" EXACT []
synonym: "stimulation of DNA metabolic process" NARROW []
synonym: "up regulation of DNA metabolic process" EXACT []
synonym: "up-regulation of DNA metabolic process" EXACT []
synonym: "upregulation of DNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006259 ! positively regulates DNA metabolic process
relationship: RO:0002213 GO:0006259 ! positively regulates DNA metabolic process

[Term]
id: GO:0051055
name: negative regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "down regulation of lipid biosynthetic process" EXACT []
synonym: "down-regulation of lipid biosynthetic process" EXACT []
synonym: "downregulation of lipid biosynthetic process" EXACT []
synonym: "inhibition of lipid biosynthetic process" NARROW []
synonym: "negative regulation of lipid anabolism" EXACT []
synonym: "negative regulation of lipid biosynthesis" EXACT []
synonym: "negative regulation of lipid formation" EXACT []
synonym: "negative regulation of lipid synthesis" EXACT []
synonym: "negative regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process
relationship: RO:0002212 GO:0008610 ! negatively regulates lipid biosynthetic process

[Term]
id: GO:0051059
name: NF-kappaB binding
namespace: molecular_function
def: "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]
is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 PR:000001753 ! has primary input transcription factor NF-kappa-B subunit
relationship: RO:0004009 PR:000001753 ! has primary input transcription factor NF-kappa-B subunit

[Term]
id: GO:0051078
name: meiotic nuclear membrane disassembly
namespace: biological_process
def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf]
synonym: "meiotic nuclear envelope breakdown" RELATED []
synonym: "meiotic nuclear envelope catabolism" RELATED []
synonym: "meiotic nuclear envelope degradation" RELATED []
synonym: "meiotic nuclear envelope disassembly" RELATED []
is_a: GO:0051081 ! nuclear membrane disassembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle

[Term]
id: GO:0051080
name: meiosis II nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes during the second division of meiosis." [GOC:bf]
synonym: "meiosis II nuclear envelope breakdown" RELATED []
synonym: "meiosis II nuclear envelope catabolism" RELATED []
synonym: "meiosis II nuclear envelope degradation" RELATED []
synonym: "meiosis II nuclear envelope disassembly" RELATED []
is_a: GO:0051078 ! meiotic nuclear membrane disassembly
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: BFO:0000050 GO:0007135 ! part of meiosis II
relationship: BFO:0000050 GO:0007135 ! part of meiosis II

[Term]
id: GO:0051081
name: nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai]
synonym: "nuclear envelope breakdown" RELATED []
synonym: "nuclear envelope catabolism" RELATED []
synonym: "nuclear envelope degradation" RELATED []
synonym: "nuclear envelope disassembly" RELATED []
is_a: GO:0030397 ! membrane disassembly
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane
relationship: RO:0002590 GO:0031965 ! results in disassembly of nuclear membrane

[Term]
id: GO:0051093
name: negative regulation of developmental process
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
synonym: "down regulation of developmental process" EXACT []
synonym: "down-regulation of developmental process" EXACT []
synonym: "downregulation of developmental process" EXACT []
synonym: "inhibition of developmental process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032502 ! negatively regulates developmental process
relationship: RO:0002212 GO:0032502 ! negatively regulates developmental process

[Term]
id: GO:0051094
name: positive regulation of developmental process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
synonym: "activation of developmental process" NARROW []
synonym: "stimulation of developmental process" NARROW []
synonym: "up regulation of developmental process" EXACT []
synonym: "up-regulation of developmental process" EXACT []
synonym: "upregulation of developmental process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032502 ! positively regulates developmental process
relationship: RO:0002213 GO:0032502 ! positively regulates developmental process

[Term]
id: GO:0051098
name: regulation of binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0005488 ! regulates binding
relationship: RO:0002211 GO:0005488 ! regulates binding

[Term]
id: GO:0051099
name: positive regulation of binding
namespace: biological_process
def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "activation of binding" NARROW []
synonym: "stimulation of binding" NARROW []
synonym: "up regulation of binding" EXACT []
synonym: "up-regulation of binding" EXACT []
synonym: "upregulation of binding" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0005488 ! positively regulates binding
relationship: RO:0002213 GO:0005488 ! positively regulates binding

[Term]
id: GO:0051100
name: negative regulation of binding
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "down regulation of binding" EXACT []
synonym: "down-regulation of binding" EXACT []
synonym: "downregulation of binding" EXACT []
synonym: "inhibition of binding" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005488 ! negatively regulates binding
relationship: RO:0002212 GO:0005488 ! negatively regulates binding

[Term]
id: GO:0051101
name: regulation of DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
is_a: GO:0051098 ! regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003677 ! regulates DNA binding
relationship: RO:0002211 GO:0003677 ! regulates DNA binding

[Term]
id: GO:0051128
name: regulation of cellular component organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "regulation of cell organisation" RELATED [GOC:mah]
synonym: "regulation of cell organization" RELATED [GOC:mah]
synonym: "regulation of cellular component organisation" EXACT []
synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016043 ! regulates cellular component organization
relationship: RO:0002211 GO:0016043 ! regulates cellular component organization

[Term]
id: GO:0051129
name: negative regulation of cellular component organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "down regulation of cell organization" EXACT []
synonym: "down-regulation of cell organization" EXACT []
synonym: "downregulation of cell organization" EXACT []
synonym: "inhibition of cell organization" NARROW []
synonym: "negative regulation of cell organisation" RELATED [GOC:mah]
synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016043 ! negatively regulates cellular component organization
relationship: RO:0002212 GO:0016043 ! negatively regulates cellular component organization

[Term]
id: GO:0051130
name: positive regulation of cellular component organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "activation of cell organization" NARROW []
synonym: "positive regulation of cell organisation" EXACT []
synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell organization" NARROW []
synonym: "up regulation of cell organization" EXACT []
synonym: "up-regulation of cell organization" EXACT []
synonym: "upregulation of cell organization" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016043 ! positively regulates cellular component organization
relationship: RO:0002213 GO:0016043 ! positively regulates cellular component organization

[Term]
id: GO:0051145
name: smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]
synonym: "nonstriated muscle cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell
relationship: RO:0002315 CL:0000192 ! results in acquisition of features of smooth muscle cell

[Term]
id: GO:0051146
name: striated muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]
synonym: "voluntary muscle cell differentiation" NARROW []
is_a: GO:0042692 ! muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell
relationship: RO:0002315 CL:0000737 ! results in acquisition of features of striated muscle cell

[Term]
id: GO:0051147
name: regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042692 ! regulates muscle cell differentiation
relationship: RO:0002211 GO:0042692 ! regulates muscle cell differentiation

[Term]
id: GO:0051148
name: negative regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "down regulation of muscle cell differentiation" EXACT []
synonym: "down-regulation of muscle cell differentiation" EXACT []
synonym: "downregulation of muscle cell differentiation" EXACT []
synonym: "inhibition of muscle cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation
relationship: RO:0002212 GO:0042692 ! negatively regulates muscle cell differentiation

[Term]
id: GO:0051149
name: positive regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "activation of muscle cell differentiation" NARROW []
synonym: "stimulation of muscle cell differentiation" NARROW []
synonym: "up regulation of muscle cell differentiation" EXACT []
synonym: "up-regulation of muscle cell differentiation" EXACT []
synonym: "upregulation of muscle cell differentiation" EXACT []
xref: Reactome:R-HSA-525793 "Myogenesis"
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation
relationship: RO:0002213 GO:0042692 ! positively regulates muscle cell differentiation

[Term]
id: GO:0051150
name: regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation
relationship: RO:0002211 GO:0051145 ! regulates smooth muscle cell differentiation

[Term]
id: GO:0051151
name: negative regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "down regulation of smooth muscle cell differentiation" EXACT []
synonym: "down-regulation of smooth muscle cell differentiation" EXACT []
synonym: "downregulation of smooth muscle cell differentiation" EXACT []
synonym: "inhibition of smooth muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation
relationship: RO:0002212 GO:0051145 ! negatively regulates smooth muscle cell differentiation

[Term]
id: GO:0051152
name: positive regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "activation of smooth muscle cell differentiation" NARROW []
synonym: "stimulation of smooth muscle cell differentiation" NARROW []
synonym: "up regulation of smooth muscle cell differentiation" EXACT []
synonym: "up-regulation of smooth muscle cell differentiation" EXACT []
synonym: "upregulation of smooth muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation
relationship: RO:0002213 GO:0051145 ! positively regulates smooth muscle cell differentiation

[Term]
id: GO:0051153
name: regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation
relationship: RO:0002211 GO:0051146 ! regulates striated muscle cell differentiation

[Term]
id: GO:0051154
name: negative regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "down regulation of striated muscle cell differentiation" EXACT []
synonym: "down-regulation of striated muscle cell differentiation" EXACT []
synonym: "downregulation of striated muscle cell differentiation" EXACT []
synonym: "inhibition of striated muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation
relationship: RO:0002212 GO:0051146 ! negatively regulates striated muscle cell differentiation

[Term]
id: GO:0051155
name: positive regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "activation of striated muscle cell differentiation" NARROW []
synonym: "stimulation of striated muscle cell differentiation" NARROW []
synonym: "up regulation of striated muscle cell differentiation" EXACT []
synonym: "up-regulation of striated muscle cell differentiation" EXACT []
synonym: "upregulation of striated muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation
relationship: RO:0002213 GO:0051146 ! positively regulates striated muscle cell differentiation

[Term]
id: GO:0051168
name: nuclear export
namespace: biological_process
def: "The directed movement of substances out of the nucleus." [GOC:ai]
synonym: "export from nucleus" EXACT []
synonym: "nucleus export" EXACT []
synonym: "substance nuclear export" EXACT []
is_a: GO:0006913 ! nucleocytoplasmic transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0031981 ! has target start location nuclear lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
relationship: RO:0002338 GO:0031981 ! has target start location nuclear lumen
relationship: RO:0002339 GO:0005829 ! has target end location cytosol

[Term]
id: GO:0051169
name: nuclear transport
namespace: biological_process
def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai]
subset: goslim_yeast
synonym: "nucleus transport" EXACT []
xref: Wikipedia:Nuclear_transport
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
intersection_of: RO:0002344 GO:0005634 ! results in transport to from or in nucleus
intersection_of: RO:0002344 GO:0005634 ! results in transport to from or in nucleus
relationship: RO:0002344 GO:0005634 ! results in transport to from or in nucleus

[Term]
id: GO:0051170
name: import into nucleus
namespace: biological_process
def: "The directed movement of substances into the nucleus." [GOC:ai]
synonym: "nuclear import" EXACT []
synonym: "nuclear translocation" EXACT []
is_a: GO:0006913 ! nucleocytoplasmic transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0031981 ! has target end location nuclear lumen
intersection_of: RO:0002342 GO:0005635 ! results in transport across nuclear envelope
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0031981 ! has target end location nuclear lumen
creation_date: 2013-12-19T15:26:34Z

[Term]
id: GO:0051174
name: regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]
synonym: "regulation of phosphorus metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006793 ! regulates phosphorus metabolic process
relationship: RO:0002211 GO:0006793 ! regulates phosphorus metabolic process

[Term]
id: GO:0051179
name: localization
namespace: biological_process
alt_id: GO:1902578
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
synonym: "localisation" EXACT [GOC:mah]
synonym: "single organism localization" RELATED [GOC:TermGenie]
synonym: "single-organism localization" RELATED []
is_a: GO:0008150 ! biological_process
created_by: jl
creation_date: 2013-12-18T13:51:04Z

[Term]
id: GO:0051216
name: cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424]
synonym: "cartilage biogenesis" EXACT []
synonym: "cartilage biosynthesis" EXACT []
synonym: "cartilage element development" EXACT []
synonym: "cartilage formation" EXACT []
synonym: "cartilage organ development" EXACT []
synonym: "chondrogenesis" EXACT []
xref: Wikipedia:Chondrogenesis
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0007844 ! results in development of cartilage element
relationship: BFO:0000050 GO:0001501 ! part of skeletal system development
relationship: BFO:0000050 GO:0061448 ! part of connective tissue development
relationship: RO:0002296 UBERON:0007844 ! results in development of cartilage element

[Term]
id: GO:0051222
name: positive regulation of protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of protein transport" NARROW []
synonym: "stimulation of protein transport" NARROW []
synonym: "up regulation of protein transport" EXACT []
synonym: "up-regulation of protein transport" EXACT []
synonym: "upregulation of protein transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0015031 ! positively regulates protein transport
relationship: RO:0002213 GO:0015031 ! positively regulates protein transport

[Term]
id: GO:0051223
name: regulation of protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015031 ! regulates protein transport
relationship: RO:0002211 GO:0015031 ! regulates protein transport

[Term]
id: GO:0051224
name: negative regulation of protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of protein transport" EXACT []
synonym: "down-regulation of protein transport" EXACT []
synonym: "downregulation of protein transport" EXACT []
synonym: "inhibition of protein transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0015031 ! negatively regulates protein transport
relationship: RO:0002212 GO:0015031 ! negatively regulates protein transport

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0051235
name: maintenance of location
namespace: biological_process
def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of localization" EXACT []
synonym: "retention" NARROW []
synonym: "sequestering" NARROW []
synonym: "storage" NARROW []
is_a: GO:0051179 ! localization

[Term]
id: GO:0051236
name: establishment of RNA localization
namespace: biological_process
def: "The directed movement of RNA to a specific location." [GOC:ai]
synonym: "establishment of RNA localisation" EXACT [GOC:mah]
synonym: "RNA positioning" EXACT []
synonym: "RNA recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: BFO:0000050 GO:0006403 ! part of RNA localization

[Term]
id: GO:0051239
name: regulation of multicellular organismal process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032501 ! regulates multicellular organismal process
relationship: RO:0002211 GO:0032501 ! regulates multicellular organismal process

[Term]
id: GO:0051240
name: positive regulation of multicellular organismal process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "activation of multicellular organismal process" NARROW []
synonym: "stimulation of multicellular organismal process" NARROW []
synonym: "up regulation of multicellular organismal process" EXACT []
synonym: "up-regulation of multicellular organismal process" EXACT []
synonym: "upregulation of multicellular organismal process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process
relationship: RO:0002213 GO:0032501 ! positively regulates multicellular organismal process

[Term]
id: GO:0051241
name: negative regulation of multicellular organismal process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "down regulation of multicellular organismal process" EXACT []
synonym: "down-regulation of multicellular organismal process" EXACT []
synonym: "downregulation of multicellular organismal process" EXACT []
synonym: "inhibition of multicellular organismal process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process
relationship: RO:0002212 GO:0032501 ! negatively regulates multicellular organismal process

[Term]
id: GO:0051246
name: regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032268
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "regulation of cellular protein metabolic process" RELATED []
synonym: "regulation of cellular protein metabolism" RELATED []
synonym: "regulation of protein metabolism" EXACT []
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019538 ! regulates protein metabolic process
relationship: RO:0002211 GO:0019538 ! regulates protein metabolic process

[Term]
id: GO:0051247
name: positive regulation of protein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "activation of cellular protein metabolic process" NARROW []
synonym: "activation of protein metabolic process" NARROW []
synonym: "positive regulation of cellular protein metabolic process" EXACT []
synonym: "positive regulation of cellular protein metabolism" EXACT []
synonym: "positive regulation of protein metabolism" EXACT []
synonym: "stimulation of cellular protein metabolic process" NARROW []
synonym: "stimulation of protein metabolic process" NARROW []
synonym: "up regulation of cellular protein metabolic process" EXACT []
synonym: "up regulation of protein metabolic process" EXACT []
synonym: "up-regulation of cellular protein metabolic process" EXACT []
synonym: "up-regulation of protein metabolic process" EXACT []
synonym: "upregulation of cellular protein metabolic process" EXACT []
synonym: "upregulation of protein metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019538 ! positively regulates protein metabolic process
relationship: RO:0002213 GO:0019538 ! positively regulates protein metabolic process

[Term]
id: GO:0051248
name: negative regulation of protein metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "down regulation of cellular protein metabolic process" EXACT []
synonym: "down regulation of protein metabolic process" EXACT []
synonym: "down-regulation of cellular protein metabolic process" EXACT []
synonym: "down-regulation of protein metabolic process" EXACT []
synonym: "downregulation of cellular protein metabolic process" EXACT []
synonym: "downregulation of protein metabolic process" EXACT []
synonym: "inhibition of cellular protein metabolic process" NARROW []
synonym: "inhibition of protein metabolic process" NARROW []
synonym: "negative regulation of cellular protein metabolic process" EXACT []
synonym: "negative regulation of cellular protein metabolism" EXACT []
synonym: "negative regulation of protein metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process
relationship: RO:0002212 GO:0019538 ! negatively regulates protein metabolic process

[Term]
id: GO:0051249
name: regulation of lymphocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046649 ! regulates lymphocyte activation
relationship: RO:0002211 GO:0046649 ! regulates lymphocyte activation

[Term]
id: GO:0051250
name: negative regulation of lymphocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "down regulation of lymphocyte activation" EXACT []
synonym: "down-regulation of lymphocyte activation" EXACT []
synonym: "downregulation of lymphocyte activation" EXACT []
synonym: "inhibition of lymphocyte activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0046649 ! negatively regulates lymphocyte activation
relationship: RO:0002212 GO:0046649 ! negatively regulates lymphocyte activation

[Term]
id: GO:0051251
name: positive regulation of lymphocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "activation of lymphocyte activation" NARROW []
synonym: "stimulation of lymphocyte activation" NARROW []
synonym: "up regulation of lymphocyte activation" EXACT []
synonym: "up-regulation of lymphocyte activation" EXACT []
synonym: "upregulation of lymphocyte activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0046649 ! positively regulates lymphocyte activation
relationship: RO:0002213 GO:0046649 ! positively regulates lymphocyte activation

[Term]
id: GO:0051252
name: regulation of RNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "regulation of RNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016070 ! regulates RNA metabolic process
relationship: RO:0002211 GO:0016070 ! regulates RNA metabolic process

[Term]
id: GO:0051253
name: negative regulation of RNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "down regulation of RNA metabolic process" EXACT []
synonym: "down-regulation of RNA metabolic process" EXACT []
synonym: "downregulation of RNA metabolic process" EXACT []
synonym: "inhibition of RNA metabolic process" NARROW []
synonym: "negative regulation of RNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process
relationship: RO:0002212 GO:0016070 ! negatively regulates RNA metabolic process

[Term]
id: GO:0051254
name: positive regulation of RNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "activation of RNA metabolic process" NARROW []
synonym: "positive regulation of RNA metabolism" EXACT []
synonym: "stimulation of RNA metabolic process" NARROW []
synonym: "up regulation of RNA metabolic process" EXACT []
synonym: "up-regulation of RNA metabolic process" EXACT []
synonym: "upregulation of RNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process
relationship: RO:0002213 GO:0016070 ! positively regulates RNA metabolic process

[Term]
id: GO:0051258
name: protein polymerization
namespace: biological_process
def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
synonym: "protein polymer biosynthesis" EXACT []
synonym: "protein polymer biosynthetic process" EXACT []
synonym: "protein polymer formation" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0051261
name: protein depolymerization
namespace: biological_process
def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
synonym: "protein polymer breakdown" EXACT []
synonym: "protein polymer catabolic process" EXACT []
synonym: "protein polymer catabolism" EXACT []
synonym: "protein polymer degradation" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0051276
name: chromosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
synonym: "chromosome organisation" EXACT []
synonym: "chromosome organization and biogenesis" RELATED [GOC:mah]
synonym: "DNA condensation" EXACT []
synonym: "DNA packaging" NARROW []
synonym: "maintenance of genome integrity" RELATED []
synonym: "nuclear genome maintenance" RELATED []
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005694 ! results in organization of chromosome
relationship: RO:0002592 GO:0005694 ! results in organization of chromosome

[Term]
id: GO:0051301
name: cell division
namespace: biological_process
def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
xref: Wikipedia:Cell_division
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051302
name: regulation of cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051301 ! regulates cell division
relationship: RO:0002211 GO:0051301 ! regulates cell division

[Term]
id: GO:0051321
name: meiotic cell cycle
namespace: biological_process
alt_id: GO:0007126
def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]
comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_drosophila
subset: goslim_yeast
synonym: "meiosis" RELATED []
xref: Wikipedia:Meiosis
is_a: GO:0007049 ! cell cycle
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0007049 ! cell cycle
intersection_of: BFO:0000051 GO:0140013 ! has part meiotic nuclear division
relationship: BFO:0000050 GO:0019953 ! part of sexual reproduction
relationship: BFO:0000051 GO:0140013 ! has part meiotic nuclear division

[Term]
id: GO:0051326
name: telophase
namespace: biological_process
def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]
comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
xref: Wikipedia:Telophase
is_a: GO:0022403 ! cell cycle phase
relationship: BFO:0000050 GO:0000279 ! part of M phase

[Term]
id: GO:0051327
name: meiotic M phase
namespace: biological_process
def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
synonym: "M phase of meiotic cell cycle" EXACT []
is_a: GO:0000279 ! M phase
is_a: GO:0098762 ! meiotic cell cycle phase
intersection_of: GO:0000279 ! M phase
intersection_of: RO:0002092 GO:0051321 ! happens during meiotic cell cycle

[Term]
id: GO:0051336
name: regulation of hydrolase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "hydrolase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016787 ! regulates hydrolase activity
relationship: RO:0002211 GO:0016787 ! regulates hydrolase activity

[Term]
id: GO:0051338
name: regulation of transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_obsoletion_candidate
synonym: "transferase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016740 ! regulates transferase activity
relationship: RO:0002211 GO:0016740 ! regulates transferase activity

[Term]
id: GO:0051378
name: serotonin binding
namespace: molecular_function
def: "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai]
synonym: "5-hydroxytryptamine binding" EXACT []
is_a: GO:0043169 ! cation binding
is_a: GO:0043176 ! amine binding
is_a: GO:1901363 ! heterocyclic compound binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:350546 ! has primary input
relationship: RO:0004009 CHEBI:350546 ! has primary input

[Term]
id: GO:0051380
name: norepinephrine binding
namespace: molecular_function
def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "noradrenaline binding" EXACT []
is_a: GO:0043169 ! cation binding
is_a: GO:1901338 ! catecholamine binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:72587 ! has primary input
relationship: RO:0004009 CHEBI:72587 ! has primary input

[Term]
id: GO:0051402
name: neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis]
synonym: "apoptosis of neuronal cells" EXACT []
synonym: "apoptosis of neurons" EXACT []
synonym: "neuron apoptosis" NARROW []
synonym: "neuron programmed cell death by apoptosis" EXACT []
synonym: "neuronal cell apoptosis" EXACT []
synonym: "neuronal cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neuronal cells by apoptosis" EXACT []
synonym: "programmed cell death of neurons by apoptosis" EXACT []
synonym: "programmed cell death, neuronal cells" EXACT []
synonym: "programmed cell death, neurons" EXACT []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron
relationship: BFO:0000066 CL:0000540 ! occurs in neuron

[Term]
id: GO:0051445
name: regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "meiotic cell cycle modulation" EXACT []
synonym: "meiotic cell cycle regulation" EXACT []
synonym: "meiotic cell cycle regulator" RELATED []
synonym: "modulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051321 ! regulates meiotic cell cycle
relationship: RO:0002211 GO:0051321 ! regulates meiotic cell cycle

[Term]
id: GO:0051446
name: positive regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of progression through meiotic cell cycle" NARROW []
synonym: "positive regulation of meiotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through meiotic cell cycle" NARROW []
synonym: "up regulation of progression through meiotic cell cycle" EXACT []
synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
synonym: "upregulation of progression through meiotic cell cycle" EXACT []
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle
relationship: RO:0002213 GO:0051321 ! positively regulates meiotic cell cycle

[Term]
id: GO:0051447
name: negative regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of progression through meiotic cell cycle" EXACT []
synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
synonym: "downregulation of progression through meiotic cell cycle" EXACT []
synonym: "inhibition of progression through meiotic cell cycle" NARROW []
synonym: "negative regulation of meiotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle
relationship: RO:0002212 GO:0051321 ! negatively regulates meiotic cell cycle

[Term]
id: GO:0051450
name: myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000056 ! acts on population of myoblast
relationship: RO:0012003 CL:0000056 ! acts on population of myoblast

[Term]
id: GO:0051451
name: myoblast migration
namespace: biological_process
def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000056 ! results in movement of myoblast
relationship: RO:0002565 CL:0000056 ! results in movement of myoblast

[Term]
id: GO:0051457
name: maintenance of protein location in nucleus
namespace: biological_process
def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai]
synonym: "maintenance of nuclear protein localization" EXACT []
synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein location in cell nucleus" EXACT []
synonym: "nuclear protein retention" NARROW []
synonym: "nuclear protein sequestering" NARROW []
synonym: "nuclear protein sequestration" NARROW []
synonym: "protein retention in nucleus" NARROW []
synonym: "protein sequestration in nucleus" NARROW []
synonym: "protein storage in nucleus" NARROW []
synonym: "protein-nuclear retention" NARROW []
synonym: "sequestration of protein in nucleus" NARROW []
synonym: "storage of protein in nucleus" NARROW []
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 GO:0005634 ! occurs in nucleus
relationship: BFO:0000050 GO:0034504 ! part of protein localization to nucleus
relationship: BFO:0000066 GO:0005634 ! occurs in nucleus
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota

[Term]
id: GO:0051458
name: corticotropin secretion
namespace: biological_process
def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [GOC:cjm, PMID:11027914]
synonym: "ACTH secretion" EXACT []
synonym: "adrenocorticotropic hormone secretion" EXACT []
synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb]
synonym: "adrenotropic hormone secretion" EXACT []
synonym: "adrenotropin secretion" EXACT []
synonym: "corticotropic hormone secretion" EXACT []
is_a: GO:0030072 ! peptide hormone secretion
is_a: GO:0060986 ! endocrine hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:3892 ! has primary input
relationship: RO:0004009 CHEBI:3892 ! has primary input

[Term]
id: GO:0051459
name: regulation of corticotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph]
synonym: "regulation of ACTH secretion" EXACT []
synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph]
synonym: "regulation of adrenocorticotropin secretion" EXACT []
synonym: "regulation of adrenotropin hormone secretion" EXACT []
synonym: "regulation of adrenotropin secretion" EXACT []
synonym: "regulation of corticotropic hormone secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051458 ! regulates corticotropin secretion
relationship: RO:0002211 GO:0051458 ! regulates corticotropin secretion

[Term]
id: GO:0051460
name: negative regulation of corticotropin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai]
synonym: "down regulation of adrenocorticotropin secretion" EXACT []
synonym: "down-regulation of adrenocorticotropin secretion" EXACT []
synonym: "downregulation of adrenocorticotropin secretion" EXACT []
synonym: "inhibition of adrenocorticotropin secretion" NARROW []
synonym: "negative regulation of ACTH secretion" EXACT []
synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenocorticotropin secretion" EXACT []
synonym: "negative regulation of adrenotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenotropin secretion" EXACT []
synonym: "negative regulation of corticotropic hormone secretion" EXACT []
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051459 ! regulation of corticotropin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051458 ! negatively regulates corticotropin secretion
relationship: RO:0002212 GO:0051458 ! negatively regulates corticotropin secretion

[Term]
id: GO:0051461
name: positive regulation of corticotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai]
synonym: "activation of adrenocorticotropin secretion" NARROW []
synonym: "positive regulation of ACTH secretion" EXACT []
synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of adrenotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenotropin secretion" EXACT []
synonym: "positive regulation of corticotropic hormone secretion" EXACT []
synonym: "stimulation of adrenocorticotropin secretion" NARROW []
synonym: "up regulation of adrenocorticotropin secretion" EXACT []
synonym: "up-regulation of adrenocorticotropin secretion" EXACT []
synonym: "upregulation of adrenocorticotropin secretion" EXACT []
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051459 ! regulation of corticotropin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051458 ! positively regulates corticotropin secretion
relationship: RO:0002213 GO:0051458 ! positively regulates corticotropin secretion

[Term]
id: GO:0051469
name: vesicle fusion with vacuole
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai]
synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED []
synonym: "heterotypic vacuole fusion, non-autophagic" RELATED []
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0097576 ! vacuole fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole
intersection_of: RO:0012008 GO:0031982 ! results in fusion of vesicle
relationship: RO:0012008 GO:0031982 ! results in fusion of vesicle

[Term]
id: GO:0051493
name: regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007010 ! regulates cytoskeleton organization
relationship: RO:0002211 GO:0007010 ! regulates cytoskeleton organization

[Term]
id: GO:0051494
name: negative regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "down regulation of cytoskeleton organization" EXACT []
synonym: "down-regulation of cytoskeleton organization" EXACT []
synonym: "downregulation of cytoskeleton organization" EXACT []
synonym: "inhibition of cytoskeleton organization" NARROW []
synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization
relationship: RO:0002212 GO:0007010 ! negatively regulates cytoskeleton organization

[Term]
id: GO:0051495
name: positive regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "activation of cytoskeleton organization" NARROW []
synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cytoskeleton organization" NARROW []
synonym: "up regulation of cytoskeleton organization" EXACT []
synonym: "up-regulation of cytoskeleton organization" EXACT []
synonym: "upregulation of cytoskeleton organization" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization
relationship: RO:0002213 GO:0007010 ! positively regulates cytoskeleton organization

[Term]
id: GO:0051588
name: regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006836 ! regulates neurotransmitter transport
relationship: RO:0002211 GO:0006836 ! regulates neurotransmitter transport

[Term]
id: GO:0051589
name: negative regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of neurotransmitter transport" EXACT []
synonym: "down-regulation of neurotransmitter transport" EXACT []
synonym: "downregulation of neurotransmitter transport" EXACT []
synonym: "inhibition of neurotransmitter transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport
relationship: RO:0002212 GO:0006836 ! negatively regulates neurotransmitter transport

[Term]
id: GO:0051590
name: positive regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of neurotransmitter transport" NARROW []
synonym: "stimulation of neurotransmitter transport" NARROW []
synonym: "up regulation of neurotransmitter transport" EXACT []
synonym: "up-regulation of neurotransmitter transport" EXACT []
synonym: "upregulation of neurotransmitter transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport
relationship: RO:0002213 GO:0006836 ! positively regulates neurotransmitter transport

[Term]
id: GO:0051606
name: detection of stimulus
namespace: biological_process
def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
subset: goslim_pir
synonym: "perception of stimulus" RELATED []
synonym: "stimulus detection" EXACT []
synonym: "stimulus sensing" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051620
name: norepinephrine uptake
namespace: biological_process
def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "levarterenol reuptake" EXACT []
synonym: "levarterenol uptake" EXACT []
synonym: "noradrenaline reuptake" EXACT []
synonym: "noradrenaline uptake" EXACT []
synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "norepinephrine reuptake" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0090493 ! catecholamine uptake
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
intersection_of: RO:0004009 CHEBI:72587 ! has primary input

[Term]
id: GO:0051621
name: regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai]
synonym: "regulation of levarterenol uptake" EXACT []
synonym: "regulation of noradrenaline uptake" EXACT []
synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051620 ! regulates norepinephrine uptake
relationship: RO:0002211 GO:0051620 ! regulates norepinephrine uptake

[Term]
id: GO:0051622
name: negative regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "down regulation of norepinephrine uptake" EXACT []
synonym: "down-regulation of norepinephrine uptake" EXACT []
synonym: "downregulation of norepinephrine uptake" EXACT []
synonym: "negative regulation of levarterenol uptake" EXACT []
synonym: "negative regulation of noradrenaline uptake" EXACT []
synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051621 ! regulation of norepinephrine uptake
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake
relationship: RO:0002212 GO:0051620 ! negatively regulates norepinephrine uptake

[Term]
id: GO:0051623
name: positive regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "activation of norepinephrine uptake" NARROW []
synonym: "positive regulation of levarterenol uptake" EXACT []
synonym: "positive regulation of noradrenaline uptake" EXACT []
synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of norepinephrine uptake" NARROW []
synonym: "up regulation of norepinephrine uptake" EXACT []
synonym: "up-regulation of norepinephrine uptake" EXACT []
synonym: "upregulation of norepinephrine uptake" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051621 ! regulation of norepinephrine uptake
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake
relationship: RO:0002213 GO:0051620 ! positively regulates norepinephrine uptake

[Term]
id: GO:0051630
name: acetylcholine uptake
namespace: biological_process
def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai]
synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015870 ! acetylcholine transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: RO:0002338 GO:0005576 ! has target start location extracellular region
relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure

[Term]
id: GO:0051631
name: regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai]
synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051630 ! regulates acetylcholine uptake
relationship: RO:0002211 GO:0051630 ! regulates acetylcholine uptake

[Term]
id: GO:0051632
name: negative regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "down regulation of acetylcholine uptake" EXACT []
synonym: "down-regulation of acetylcholine uptake" EXACT []
synonym: "downregulation of acetylcholine uptake" EXACT []
synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051953 ! negative regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake
relationship: RO:0002212 GO:0051630 ! negatively regulates acetylcholine uptake

[Term]
id: GO:0051633
name: positive regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "activation of acetylcholine uptake" NARROW []
synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of acetylcholine uptake" NARROW []
synonym: "up regulation of acetylcholine uptake" EXACT []
synonym: "up-regulation of acetylcholine uptake" EXACT []
synonym: "upregulation of acetylcholine uptake" EXACT []
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051954 ! positive regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake
relationship: RO:0002213 GO:0051630 ! positively regulates acetylcholine uptake

[Term]
id: GO:0051640
name: organelle localization
namespace: biological_process
def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "establishment and maintenance of organelle localization" EXACT []
synonym: "organelle localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0043226 ! has primary input organelle
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
relationship: RO:0004009 GO:0043226 ! has primary input organelle

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
alt_id: GO:1902580
def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
synonym: "single organism cellular localization" EXACT [GOC:TermGenie]
synonym: "single-organism cellular localization" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization
created_by: jl
creation_date: 2013-12-18T14:04:32Z

[Term]
id: GO:0051644
name: plastid localization
namespace: biological_process
def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of plastid localization" EXACT []
synonym: "plastid localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0009536 ! has primary input plastid
relationship: RO:0004009 GO:0009536 ! has primary input plastid

[Term]
id: GO:0051645
name: Golgi localization
namespace: biological_process
def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of Golgi localization" EXACT []
synonym: "Golgi apparatus localization" EXACT []
synonym: "Golgi body localization" EXACT []
synonym: "Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus
relationship: RO:0004009 GO:0005794 ! has primary input Golgi apparatus

[Term]
id: GO:0051646
name: mitochondrion localization
namespace: biological_process
def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of mitochondria localization" EXACT []
synonym: "establishment and maintenance of mitochondrion localization" EXACT []
synonym: "localization of mitochondria" EXACT []
synonym: "localization of mitochondrion" EXACT []
synonym: "mitochondria localization" EXACT []
synonym: "mitochondrial localization" EXACT []
synonym: "mitochondrion localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion
relationship: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0051647
name: nucleus localization
namespace: biological_process
def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "cell nucleus localization" EXACT []
synonym: "establishment and maintenance of nucleus localization" EXACT []
synonym: "localization of nucleus" EXACT []
synonym: "nucleus localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus
relationship: RO:0004009 GO:0005634 ! has primary input nucleus

[Term]
id: GO:0051648
name: vesicle localization
namespace: biological_process
def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cytoplasmic vesicle localization" EXACT []
synonym: "establishment and maintenance of vesicle localization" EXACT []
synonym: "vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle
relationship: RO:0004009 GO:0031982 ! has primary input vesicle

[Term]
id: GO:0051649
name: establishment of localization in cell
namespace: biological_process
def: "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of intracellular localization" NARROW []
synonym: "establishment of localisation in cell" EXACT [GOC:mah]
synonym: "establishment of localization within cell" NARROW []
synonym: "positioning within cell" NARROW []
is_a: GO:0051234 ! establishment of localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
relationship: BFO:0000050 GO:0051641 ! part of cellular localization
relationship: BFO:0000066 CL:0000000 ! occurs in cell
relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms

[Term]
id: GO:0051650
name: establishment of vesicle localization
namespace: biological_process
def: "The directed movement of a vesicle to a specific location." [GOC:ai]
synonym: "establishment of vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle

[Term]
id: GO:0051651
name: maintenance of location in cell
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]
synonym: "cellular retention" NARROW []
synonym: "cellular sequestering" NARROW []
synonym: "cellular storage" NARROW []
synonym: "intracellular retention" NARROW []
synonym: "intracellular sequestering" NARROW []
synonym: "intracellular storage" NARROW []
synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of intracellular localization" NARROW []
synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of localization within cell" NARROW []
synonym: "retention within cell" NARROW []
synonym: "sequestering within cell" NARROW []
synonym: "storage within cell" NARROW []
is_a: GO:0009987 ! cellular process
is_a: GO:0051235 ! maintenance of location
intersection_of: GO:0051235 ! maintenance of location
intersection_of: BFO:0000066 CL:0000000 ! occurs in cell
relationship: BFO:0000050 GO:0051641 ! part of cellular localization
relationship: BFO:0000066 CL:0000000 ! occurs in cell

[Term]
id: GO:0051654
name: establishment of mitochondrion localization
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location." [GOC:ai]
synonym: "establishment of mitochondria localization" EXACT []
synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah]
synonym: "mitochondria positioning" EXACT []
synonym: "mitochondrial migration" EXACT []
synonym: "mitochondrion positioning" EXACT []
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0051655
name: maintenance of vesicle location
namespace: biological_process
def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051657 ! maintenance of organelle location
intersection_of: GO:0051651 ! maintenance of location in cell
intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle

[Term]
id: GO:0051656
name: establishment of organelle localization
namespace: biological_process
def: "The directed movement of an organelle to a specific location." [GOC:ai]
synonym: "establishment of organelle localisation" EXACT [GOC:mah]
is_a: GO:0051234 ! establishment of localization
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 GO:0043226 ! has primary input organelle

[Term]
id: GO:0051657
name: maintenance of organelle location
namespace: biological_process
def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051651 ! maintenance of location in cell
relationship: BFO:0000050 GO:0051640 ! part of organelle localization

[Term]
id: GO:0051658
name: maintenance of nucleus location
namespace: biological_process
def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of cell nucleus location" EXACT []
synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051657 ! maintenance of organelle location
intersection_of: GO:0051651 ! maintenance of location in cell
intersection_of: RO:0004009 GO:0005634 ! has primary input nucleus

[Term]
id: GO:0051659
name: maintenance of mitochondrion location
namespace: biological_process
def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of mitochondria localization" EXACT []
synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051646 ! mitochondrion localization
is_a: GO:0051657 ! maintenance of organelle location
intersection_of: GO:0051651 ! maintenance of location in cell
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0051667
name: establishment of plastid localization
namespace: biological_process
def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai]
synonym: "establishment of plastid localisation" EXACT [GOC:mah]
is_a: GO:0051644 ! plastid localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 GO:0009536 ! has primary input plastid

[Term]
id: GO:0051668
name: localization within membrane
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]
synonym: "establishment and maintenance of localization in membrane" EXACT []
synonym: "establishment and maintenance of position in membrane" EXACT []
synonym: "localisation within membrane" EXACT [GOC:mah]
synonym: "localization to membrane" EXACT []
synonym: "positioning within membrane" NARROW []
is_a: GO:0051641 ! cellular localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0002339 GO:0016020 ! has target end location membrane
relationship: RO:0002339 GO:0016020 ! has target end location membrane

[Term]
id: GO:0051674
name: localization of cell
namespace: biological_process
def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cell localization" EXACT []
synonym: "establishment and maintenance of cell localization" EXACT []
synonym: "establishment and maintenance of localization of cell" EXACT []
synonym: "localisation of cell" EXACT [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 CL:0000000 ! has primary input cell
relationship: RO:0004009 CL:0000000 ! has primary input cell

[Term]
id: GO:0051683
name: establishment of Golgi localization
namespace: biological_process
def: "The directed movement of the Golgi to a specific location." [GOC:ai]
synonym: "establishment of Golgi apparatus localization" EXACT []
synonym: "establishment of Golgi body localization" EXACT []
synonym: "establishment of Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus

[Term]
id: GO:0051684
name: maintenance of Golgi location
namespace: biological_process
def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of Golgi apparatus localization" EXACT []
synonym: "maintenance of Golgi body localization" EXACT []
synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051657 ! maintenance of organelle location
intersection_of: GO:0051651 ! maintenance of location in cell
intersection_of: RO:0004009 GO:0005794 ! has primary input Golgi apparatus

[Term]
id: GO:0051688
name: maintenance of plastid location
namespace: biological_process
def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051644 ! plastid localization
is_a: GO:0051657 ! maintenance of organelle location
intersection_of: GO:0051651 ! maintenance of location in cell
intersection_of: RO:0004009 GO:0009536 ! has primary input plastid

[Term]
id: GO:0051701
name: biological process involved in interaction with host
namespace: biological_process
alt_id: GO:0044112
alt_id: GO:0044116
alt_id: GO:0044117
alt_id: GO:0044119
alt_id: GO:0044121
alt_id: GO:0044123
alt_id: GO:0044125
def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
synonym: "growth of symbiont in host" NARROW []
synonym: "growth of symbiont in host cell" NARROW []
synonym: "growth of symbiont in host organelle" NARROW []
synonym: "growth of symbiont in host vacuole" NARROW []
synonym: "interaction with host" EXACT []
xref: Reactome:R-HSA-9635486 "Infection with Mycobacterium tuberculosis"
xref: Reactome:R-HSA-9658195 "Leishmania infection"
is_a: GO:0044403 ! biological process involved in symbiotic interaction

[Term]
id: GO:0051704
name: multi-organism process
def: "A biological process which involves another organism of the same or different species." []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051707
name: response to other organism
namespace: biological_process
alt_id: GO:0009613
alt_id: GO:0042828
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms

[Term]
id: GO:0051716
name: cellular response to stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
xref: Reactome:R-HSA-8953897 "Cellular responses to stimuli"
is_a: GO:0009987 ! cellular process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051726
name: regulation of cell cycle
namespace: biological_process
alt_id: GO:0000074
alt_id: GO:0007050
alt_id: GO:0071156
alt_id: GO:0071157
alt_id: GO:0071158
alt_id: GO:0071850
def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah]
synonym: "cell cycle arrest" NARROW []
synonym: "cell cycle modulation" EXACT []
synonym: "cell cycle regulation" EXACT []
synonym: "cell cycle regulator" RELATED []
synonym: "control of cell cycle progression" EXACT []
synonym: "mitotic cell cycle arrest" NARROW []
synonym: "modulation of cell cycle progression" EXACT []
synonym: "negative regulation of cell cycle arrest" NARROW []
synonym: "positive regulation of cell cycle arrest" NARROW []
synonym: "regulation of cell cycle arrest" NARROW []
synonym: "regulation of cell cycle progression" EXACT []
synonym: "regulation of progression through cell cycle" EXACT []
synonym: "tumor suppressor" RELATED []
xref: Reactome:R-HSA-156711 "Polo-like kinase mediated events"
xref: Reactome:R-HSA-380972 "Energy dependent regulation of mTOR by LKB1-AMPK"
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007049 ! regulates cell cycle
relationship: RO:0002211 GO:0007049 ! regulates cell cycle

[Term]
id: GO:0051781
name: positive regulation of cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
synonym: "activation of cell division" NARROW []
synonym: "stimulation of cell division" NARROW []
synonym: "up regulation of cell division" EXACT []
synonym: "up-regulation of cell division" EXACT []
synonym: "upregulation of cell division" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051301 ! positively regulates cell division
relationship: RO:0002213 GO:0051301 ! positively regulates cell division

[Term]
id: GO:0051782
name: negative regulation of cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai]
synonym: "down regulation of cell division" EXACT []
synonym: "down-regulation of cell division" EXACT []
synonym: "downregulation of cell division" EXACT []
synonym: "inhibition of cell division" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051301 ! negatively regulates cell division
relationship: RO:0002212 GO:0051301 ! negatively regulates cell division

[Term]
id: GO:0051783
name: regulation of nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000280 ! regulates nuclear division
relationship: RO:0002211 GO:0000280 ! regulates nuclear division

[Term]
id: GO:0051784
name: negative regulation of nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "down regulation of nuclear division" EXACT []
synonym: "down-regulation of nuclear division" EXACT []
synonym: "downregulation of nuclear division" EXACT []
synonym: "inhibition of nuclear division" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000280 ! negatively regulates nuclear division
relationship: RO:0002212 GO:0000280 ! negatively regulates nuclear division

[Term]
id: GO:0051785
name: positive regulation of nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "activation of nuclear division" NARROW []
synonym: "stimulation of nuclear division" NARROW []
synonym: "up regulation of nuclear division" EXACT []
synonym: "up-regulation of nuclear division" EXACT []
synonym: "upregulation of nuclear division" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000280 ! positively regulates nuclear division
relationship: RO:0002213 GO:0000280 ! positively regulates nuclear division

[Term]
id: GO:0051875
name: pigment granule localization
namespace: biological_process
def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule
relationship: BFO:0000050 GO:0033059 ! part of cellular pigmentation
relationship: RO:0004009 GO:0048770 ! has primary input pigment granule

[Term]
id: GO:0051890
name: regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
is_a: GO:1905207 ! regulation of cardiocyte differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010002 ! regulates cardioblast differentiation
relationship: RO:0002211 GO:0010002 ! regulates cardioblast differentiation

[Term]
id: GO:0051891
name: positive regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "activation of cardioblast differentiation" NARROW []
synonym: "stimulation of cardioblast differentiation" NARROW []
synonym: "up regulation of cardioblast differentiation" EXACT []
synonym: "up-regulation of cardioblast differentiation" EXACT []
synonym: "upregulation of cardioblast differentiation" EXACT []
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation
relationship: RO:0002213 GO:0010002 ! positively regulates cardioblast differentiation

[Term]
id: GO:0051892
name: negative regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "down regulation of cardioblast differentiation" EXACT []
synonym: "down-regulation of cardioblast differentiation" EXACT []
synonym: "downregulation of cardioblast differentiation" EXACT []
synonym: "inhibition of cardioblast differentiation" NARROW []
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation
relationship: RO:0002212 GO:0010002 ! negatively regulates cardioblast differentiation

[Term]
id: GO:0051904
name: pigment granule transport
namespace: biological_process
def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "pigment granule translocation" EXACT []
is_a: GO:0006810 ! transport
is_a: GO:0051875 ! pigment granule localization
is_a: GO:0051905 ! establishment of pigment granule localization
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 GO:0048770 ! has primary input pigment granule

[Term]
id: GO:0051905
name: establishment of pigment granule localization
namespace: biological_process
def: "The directed movement of a pigment granule to a specific location." [GOC:ai]
synonym: "establishment of pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: BFO:0000050 GO:0051875 ! part of pigment granule localization

[Term]
id: GO:0051930
name: regulation of sensory perception of pain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0051931 ! regulation of sensory perception
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019233 ! regulates sensory perception of pain
relationship: RO:0002211 GO:0019233 ! regulates sensory perception of pain

[Term]
id: GO:0051931
name: regulation of sensory perception
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0031644 ! regulation of nervous system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007600 ! regulates sensory perception
relationship: RO:0002211 GO:0007600 ! regulates sensory perception

[Term]
id: GO:0051932
name: synaptic transmission, GABAergic
namespace: biological_process
def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, ISBN:0126603030]
synonym: "GABAergic synaptic transmission" EXACT []
synonym: "synaptic transmission, GABA mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission
intersection_of: GO:0007268 ! chemical synaptic transmission
intersection_of: RO:0000057 CHEBI:59888 ! has participant
intersection_of: RO:0000057 CL:0000617 ! has participant GABAergic neuron
relationship: RO:0000057 CHEBI:59888 ! has participant
relationship: RO:0000057 CL:0000617 ! has participant GABAergic neuron

[Term]
id: GO:0051937
name: catecholamine transport
namespace: biological_process
def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
relationship: RO:0004009 CHEBI:33567 ! has primary input

[Term]
id: GO:0051938
name: L-glutamate import
namespace: biological_process
def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015807 ! L-amino acid transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
relationship: RO:0004009 CHEBI:29985 ! has primary input

[Term]
id: GO:0051939
name: gamma-aminobutyric acid import
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai]
synonym: "4-aminobutyrate import" EXACT []
synonym: "GABA import" EXACT []
synonym: "gamma-aminobutyrate import" EXACT []
synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015812 ! gamma-aminobutyric acid transport
intersection_of: GO:0015800 ! acidic amino acid transport
intersection_of: RO:0004009 CHEBI:59888 ! has primary input

[Term]
id: GO:0051952
name: regulation of amine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015837 ! regulates amine transport
relationship: RO:0002211 GO:0015837 ! regulates amine transport

[Term]
id: GO:0051953
name: negative regulation of amine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amine transport" EXACT []
synonym: "down-regulation of amine transport" EXACT []
synonym: "downregulation of amine transport" EXACT []
synonym: "inhibition of amine transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0015837 ! negatively regulates amine transport
relationship: RO:0002212 GO:0015837 ! negatively regulates amine transport

[Term]
id: GO:0051954
name: positive regulation of amine transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amine transport" NARROW []
synonym: "stimulation of amine transport" NARROW []
synonym: "up regulation of amine transport" EXACT []
synonym: "up-regulation of amine transport" EXACT []
synonym: "upregulation of amine transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0015837 ! positively regulates amine transport
relationship: RO:0002213 GO:0015837 ! positively regulates amine transport

[Term]
id: GO:0051955
name: regulation of amino acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006865 ! regulates amino acid transport
relationship: RO:0002211 GO:0006865 ! regulates amino acid transport

[Term]
id: GO:0051956
name: negative regulation of amino acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amino acid transport" EXACT []
synonym: "down-regulation of amino acid transport" EXACT []
synonym: "downregulation of amino acid transport" EXACT []
synonym: "inhibition of amino acid transport" NARROW []
synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah]
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006865 ! negatively regulates amino acid transport
relationship: RO:0002212 GO:0006865 ! negatively regulates amino acid transport

[Term]
id: GO:0051957
name: positive regulation of amino acid transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amino acid transport" NARROW []
synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah]
synonym: "stimulation of amino acid transport" NARROW []
synonym: "up regulation of amino acid transport" EXACT []
synonym: "up-regulation of amino acid transport" EXACT []
synonym: "upregulation of amino acid transport" EXACT []
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006865 ! positively regulates amino acid transport
relationship: RO:0002213 GO:0006865 ! positively regulates amino acid transport

[Term]
id: GO:0051960
name: regulation of nervous system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007399 ! regulates nervous system development
relationship: RO:0002211 GO:0007399 ! regulates nervous system development

[Term]
id: GO:0051961
name: negative regulation of nervous system development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "down regulation of nervous system development" EXACT []
synonym: "down-regulation of nervous system development" EXACT []
synonym: "downregulation of nervous system development" EXACT []
synonym: "inhibition of nervous system development" NARROW []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007399 ! negatively regulates nervous system development
relationship: RO:0002212 GO:0007399 ! negatively regulates nervous system development

[Term]
id: GO:0051962
name: positive regulation of nervous system development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "activation of nervous system development" NARROW []
synonym: "stimulation of nervous system development" NARROW []
synonym: "up regulation of nervous system development" EXACT []
synonym: "up-regulation of nervous system development" EXACT []
synonym: "upregulation of nervous system development" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007399 ! positively regulates nervous system development
relationship: RO:0002213 GO:0007399 ! positively regulates nervous system development

[Term]
id: GO:0051963
name: regulation of synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "regulation of synapse biogenesis" EXACT []
synonym: "regulation of synaptogenesis" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007416 ! regulates synapse assembly
relationship: RO:0002211 GO:0007416 ! regulates synapse assembly

[Term]
id: GO:0051964
name: negative regulation of synapse assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "down regulation of synapse assembly" EXACT []
synonym: "down-regulation of synapse assembly" EXACT []
synonym: "downregulation of synapse assembly" EXACT []
synonym: "inhibition of synapse assembly" NARROW []
synonym: "negative regulation of synapse biogenesis" EXACT []
synonym: "negative regulation of synaptogenesis" EXACT []
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007416 ! negatively regulates synapse assembly
relationship: RO:0002212 GO:0007416 ! negatively regulates synapse assembly

[Term]
id: GO:0051965
name: positive regulation of synapse assembly
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "activation of synapse assembly" NARROW []
synonym: "positive regulation of synapse biogenesis" EXACT []
synonym: "positive regulation of synaptogenesis" EXACT []
synonym: "stimulation of synapse assembly" NARROW []
synonym: "up regulation of synapse assembly" EXACT []
synonym: "up-regulation of synapse assembly" EXACT []
synonym: "upregulation of synapse assembly" EXACT []
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901890 ! positive regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007416 ! positively regulates synapse assembly
relationship: RO:0002213 GO:0007416 ! positively regulates synapse assembly

[Term]
id: GO:0051966
name: regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035249 ! regulates synaptic transmission, glutamatergic
relationship: RO:0002211 GO:0035249 ! regulates synaptic transmission, glutamatergic

[Term]
id: GO:0051967
name: negative regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "down regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "downregulation of synaptic transmission, glutamatergic" EXACT []
synonym: "inhibition of synaptic transmission, glutamatergic" NARROW []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035249 ! negatively regulates synaptic transmission, glutamatergic
relationship: RO:0002212 GO:0035249 ! negatively regulates synaptic transmission, glutamatergic

[Term]
id: GO:0051968
name: positive regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "activation of synaptic transmission, glutamatergic" NARROW []
synonym: "stimulation of synaptic transmission, glutamatergic" NARROW []
synonym: "up regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "upregulation of synaptic transmission, glutamatergic" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035249 ! positively regulates synaptic transmission, glutamatergic
relationship: RO:0002213 GO:0035249 ! positively regulates synaptic transmission, glutamatergic

[Term]
id: GO:0051969
name: regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0031644 ! regulation of nervous system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse
relationship: RO:0002211 GO:0019226 ! regulates transmission of nerve impulse

[Term]
id: GO:0051970
name: negative regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "down regulation of transmission of nerve impulse" EXACT []
synonym: "down-regulation of transmission of nerve impulse" EXACT []
synonym: "downregulation of transmission of nerve impulse" EXACT []
synonym: "inhibition of transmission of nerve impulse" NARROW []
synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse
relationship: RO:0002212 GO:0019226 ! negatively regulates transmission of nerve impulse

[Term]
id: GO:0051971
name: positive regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "activation of transmission of nerve impulse" NARROW []
synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of transmission of nerve impulse" NARROW []
synonym: "up regulation of transmission of nerve impulse" EXACT []
synonym: "up-regulation of transmission of nerve impulse" EXACT []
synonym: "upregulation of transmission of nerve impulse" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse
relationship: RO:0002213 GO:0019226 ! positively regulates transmission of nerve impulse

[Term]
id: GO:0051983
name: regulation of chromosome segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007059 ! regulates chromosome segregation
relationship: RO:0002211 GO:0007059 ! regulates chromosome segregation

[Term]
id: GO:0051984
name: positive regulation of chromosome segregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "activation of chromosome segregation" NARROW []
synonym: "stimulation of chromosome segregation" NARROW []
synonym: "up regulation of chromosome segregation" EXACT []
synonym: "up-regulation of chromosome segregation" EXACT []
synonym: "upregulation of chromosome segregation" EXACT []
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007059 ! positively regulates chromosome segregation
relationship: RO:0002213 GO:0007059 ! positively regulates chromosome segregation

[Term]
id: GO:0051985
name: negative regulation of chromosome segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "down regulation of chromosome segregation" EXACT []
synonym: "down-regulation of chromosome segregation" EXACT []
synonym: "downregulation of chromosome segregation" EXACT []
synonym: "inhibition of chromosome segregation" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation
relationship: RO:0002212 GO:0007059 ! negatively regulates chromosome segregation

[Term]
id: GO:0052372
name: modulation by symbiont of entry into host
namespace: biological_process
alt_id: GO:0052371
def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED []
synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "regulation by organism of entry into other organism involved in symbiotic interaction" RELATED []
is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044409 ! regulates entry into host
relationship: RO:0002211 GO:0044409 ! regulates entry into host

[Term]
id: GO:0052547
name: regulation of peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai]
subset: gocheck_obsoletion_candidate
synonym: "peptidase regulator activity" RELATED []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008233 ! regulates peptidase activity
relationship: RO:0002211 GO:0008233 ! regulates peptidase activity

[Term]
id: GO:0055001
name: muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]
synonym: "muscle fiber development" EXACT []
synonym: "muscle fibre development" EXACT []
synonym: "myofiber development" EXACT []
synonym: "myofibre development" EXACT []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000187 ! results in development of muscle cell
relationship: BFO:0000050 GO:0042692 ! part of muscle cell differentiation
relationship: RO:0002296 CL:0000187 ! results in development of muscle cell

[Term]
id: GO:0055002
name: striated muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol]
is_a: GO:0055001 ! muscle cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000737 ! results in development of striated muscle cell
relationship: BFO:0000050 GO:0051146 ! part of striated muscle cell differentiation
relationship: RO:0002296 CL:0000737 ! results in development of striated muscle cell

[Term]
id: GO:0055003
name: cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "cardiac myofibril development" EXACT []
synonym: "cardiac myofibril morphogenesis" EXACT []
synonym: "heart myofibril assembly" RELATED []
is_a: GO:0030239 ! myofibril assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril
relationship: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development
relationship: RO:0002588 GO:0097512 ! results in assembly of cardiac myofibril

[Term]
id: GO:0055006
name: cardiac cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol]
synonym: "cardiocyte development" EXACT [GOC:dph]
synonym: "heart cell development" RELATED []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0002494 ! results in development of cardiocyte
relationship: BFO:0000050 GO:0035051 ! part of cardiocyte differentiation
relationship: RO:0002296 CL:0002494 ! results in development of cardiocyte

[Term]
id: GO:0055007
name: cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte differentiation" EXACT []
synonym: "heart muscle cell differentiation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0051146 ! striated muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell
relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development
relationship: RO:0002315 CL:0000746 ! results in acquisition of features of cardiac muscle cell

[Term]
id: GO:0055008
name: cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol]
synonym: "heart muscle morphogenesis" EXACT []
synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development
relationship: RO:0002298 UBERON:0001133 ! results in morphogenesis of cardiac muscle tissue

[Term]
id: GO:0055009
name: atrial cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol]
synonym: "atrial heart muscle morphogenesis" EXACT []
synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac atrium muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium
relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis
relationship: BFO:0000050 GO:0003228 ! part of atrial cardiac muscle tissue development
relationship: RO:0002298 UBERON:0004490 ! results in morphogenesis of cardiac muscle tissue of atrium

[Term]
id: GO:0055010
name: ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol]
synonym: "cardiac ventricle muscle morphogenesis" EXACT []
synonym: "ventricular heart muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle
relationship: BFO:0000050 GO:0003208 ! part of cardiac ventricle morphogenesis
relationship: BFO:0000050 GO:0003229 ! part of ventricular cardiac muscle tissue development
relationship: RO:0002298 UBERON:0018649 ! results in morphogenesis of cardiac muscle tissue of ventricle

[Term]
id: GO:0055013
name: cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiac muscle fiber development" EXACT []
synonym: "cardiac muscle fibre development" EXACT []
synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle]
synonym: "heart muscle cell development" EXACT []
synonym: "heart muscle fiber development" RELATED []
is_a: GO:0055002 ! striated muscle cell development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell
relationship: BFO:0000050 GO:0055007 ! part of cardiac muscle cell differentiation
relationship: RO:0002296 CL:0000746 ! results in development of cardiac muscle cell

[Term]
id: GO:0055017
name: cardiac muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol]
synonym: "heart muscle growth" EXACT []
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue
relationship: BFO:0000050 GO:0048738 ! part of cardiac muscle tissue development
relationship: BFO:0000050 GO:0060419 ! part of heart growth
relationship: RO:0002343 UBERON:0001133 ! results in growth of cardiac muscle tissue

[Term]
id: GO:0055018
name: regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "regulation of cardiac muscle fibre development" EXACT []
synonym: "regulation of heart muscle fiber development" EXACT []
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development
relationship: RO:0002211 GO:0055013 ! regulates cardiac muscle cell development

[Term]
id: GO:0055019
name: negative regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "down regulation of cardiac muscle fiber development" EXACT []
synonym: "down-regulation of cardiac muscle fiber development" EXACT []
synonym: "downregulation of cardiac muscle fiber development" EXACT []
synonym: "inhibition of cardiac muscle fiber development" NARROW []
synonym: "negative regulation of cardiac muscle fibre development" EXACT []
synonym: "negative regulation of heart muscle fiber development" RELATED []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development
relationship: RO:0002212 GO:0055013 ! negatively regulates cardiac muscle cell development

[Term]
id: GO:0055020
name: positive regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "activation of cardiac muscle fiber development" NARROW []
synonym: "positive regulation of cardiac muscle fibre development" EXACT []
synonym: "positive regulation of heart muscle fiber development" EXACT []
synonym: "stimulation of cardiac muscle fiber development" NARROW []
synonym: "up regulation of cardiac muscle fiber development" EXACT []
synonym: "up-regulation of cardiac muscle fiber development" EXACT []
synonym: "upregulation of cardiac muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development
relationship: RO:0002213 GO:0055013 ! positively regulates cardiac muscle cell development

[Term]
id: GO:0055021
name: regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth
relationship: RO:0002211 GO:0055017 ! regulates cardiac muscle tissue growth

[Term]
id: GO:0055022
name: negative regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "down regulation of cardiac muscle growth" EXACT []
synonym: "down-regulation of cardiac muscle growth" EXACT []
synonym: "downregulation of cardiac muscle growth" EXACT []
synonym: "inhibition of cardiac muscle growth" NARROW []
synonym: "negative regulation of heart muscle growth" RELATED []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0061117 ! negative regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth
relationship: RO:0002212 GO:0055017 ! negatively regulates cardiac muscle tissue growth

[Term]
id: GO:0055023
name: positive regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "activation of cardiac muscle growth" NARROW []
synonym: "positive regulation of heart muscle growth" EXACT []
synonym: "stimulation of cardiac muscle growth" NARROW []
synonym: "up regulation of cardiac muscle growth" EXACT []
synonym: "up-regulation of cardiac muscle growth" EXACT []
synonym: "upregulation of cardiac muscle growth" EXACT []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0060421 ! positive regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth
relationship: RO:0002213 GO:0055017 ! positively regulates cardiac muscle tissue growth

[Term]
id: GO:0055024
name: regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "regulation of heart muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development
relationship: RO:0002211 GO:0048738 ! regulates cardiac muscle tissue development

[Term]
id: GO:0055025
name: positive regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "activation of cardiac muscle development" NARROW []
synonym: "positive regulation of heart muscle development" EXACT []
synonym: "stimulation of cardiac muscle development" NARROW []
synonym: "up regulation of cardiac muscle development" EXACT []
synonym: "up-regulation of cardiac muscle development" EXACT []
synonym: "upregulation of cardiac muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development
relationship: RO:0002213 GO:0048738 ! positively regulates cardiac muscle tissue development

[Term]
id: GO:0055026
name: negative regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "down regulation of cardiac muscle development" EXACT []
synonym: "down-regulation of cardiac muscle development" EXACT []
synonym: "downregulation of cardiac muscle development" EXACT []
synonym: "inhibition of cardiac muscle development" NARROW []
synonym: "negative regulation of heart muscle development" EXACT []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development
relationship: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development

[Term]
id: GO:0055057
name: neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167]
synonym: "neuroblast cell division" EXACT []
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata)
relationship: BFO:0000050 GO:0007405 ! part of neuroblast proliferation
relationship: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata)

[Term]
id: GO:0055059
name: asymmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0045165 ! cell fate commitment
is_a: GO:0055057 ! neuroblast division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: RO:0004009 CL:0000031 ! has primary input neuroblast (sensu Vertebrata)

[Term]
id: GO:0055085
name: transmembrane transport
namespace: biological_process
alt_id: GO:0090662
def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "ATP hydrolysis coupled transmembrane transport" NARROW []
synonym: "membrane transport" EXACT []
xref: Reactome:R-HSA-382556 "ABC-family proteins mediated transport"
xref: Reactome:R-HSA-425407 "SLC-mediated transmembrane transport"
xref: Reactome:R-HSA-5223345 "Miscellaneous transport and binding events"
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
relationship: RO:0002342 GO:0016020 ! results in transport across membrane
created_by: tb
creation_date: 2015-10-21T13:22:47Z

[Term]
id: GO:0055086
name: nucleobase-containing small molecule metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT []
xref: Reactome:R-HSA-15869 "Metabolism of nucleotides"
xref: Reactome:R-HSA-2393930 "Phosphate bond hydrolysis by NUDT proteins"
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0055107
name: Golgi to secretory granule transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators]
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
intersection_of: RO:0002339 GO:0030141 ! has target end location secretory granule
relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
relationship: RO:0002339 GO:0030141 ! has target end location secretory granule

[Term]
id: GO:0055108
name: Golgi to transport vesicle transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid]
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
intersection_of: RO:0002339 GO:0030133 ! has target end location transport vesicle
relationship: BFO:0000050 GO:0048193 ! part of Golgi vesicle transport
relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
relationship: RO:0002339 GO:0030133 ! has target end location transport vesicle

[Term]
id: GO:0055117
name: regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction
relationship: RO:0002211 GO:0060048 ! regulates cardiac muscle contraction

[Term]
id: GO:0055118
name: negative regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0045822 ! negative regulation of heart contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction
relationship: RO:0002212 GO:0060048 ! negatively regulates cardiac muscle contraction

[Term]
id: GO:0055123
name: digestive system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001007 ! results in development of digestive system
relationship: RO:0002296 UBERON:0001007 ! results in development of digestive system

[Term]
id: GO:0060012
name: synaptic transmission, glycinergic
namespace: biological_process
def: "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]
synonym: "glycinergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission
relationship: RO:0000057 CHEBI:57305 ! has participant

[Term]
id: GO:0060019
name: radial glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph]
is_a: GO:0010001 ! glial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000681 ! results in acquisition of features of radial glial cell
relationship: RO:0002315 CL:0000681 ! results in acquisition of features of radial glial cell

[Term]
id: GO:0060020
name: Bergmann glial cell differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501]
is_a: GO:0048708 ! astrocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000644 ! results in acquisition of features of Bergmann glial cell
relationship: RO:0002315 CL:0000644 ! results in acquisition of features of Bergmann glial cell

[Term]
id: GO:0060037
name: pharyngeal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system
relationship: BFO:0000050 GO:0043009 ! part of chordate embryonic development
relationship: RO:0002296 UBERON:0008814 ! results in development of pharyngeal arch system

[Term]
id: GO:0060038
name: cardiac muscle cell proliferation
namespace: biological_process
def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571]
synonym: "cardiac myocyte proliferation" EXACT []
synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473]
synonym: "heart muscle cell proliferation" EXACT []
is_a: GO:0014855 ! striated muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell
relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth
relationship: RO:0012003 CL:0000746 ! acts on population of cardiac muscle cell

[Term]
id: GO:0060039
name: pericardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002407 ! results in development of pericardium
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0002407 ! results in development of pericardium

[Term]
id: GO:0060041
name: retina development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729]
synonym: "retina development in camera-style eye" EXACT []
synonym: "retinal development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: BFO:0000050 GO:0043010 ! part of camera-type eye development
intersection_of: RO:0002296 UBERON:0000966 ! results in development of retina
relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development
relationship: RO:0002296 UBERON:0000966 ! results in development of retina

[Term]
id: GO:0060042
name: retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu]
synonym: "retina morphogenesis in camera-style eye" EXACT []
synonym: "retinogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina
relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis
relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye
relationship: RO:0002298 UBERON:0000966 ! results in morphogenesis of retina

[Term]
id: GO:0060043
name: regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph]
synonym: "regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation
relationship: RO:0002211 GO:0060038 ! regulates cardiac muscle cell proliferation

[Term]
id: GO:0060044
name: negative regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "negative regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation
relationship: RO:0002212 GO:0060038 ! negatively regulates cardiac muscle cell proliferation

[Term]
id: GO:0060045
name: positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "positive regulation of heart muscle cell proliferation" RELATED []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation
relationship: RO:0002213 GO:0060038 ! positively regulates cardiac muscle cell proliferation

[Term]
id: GO:0060047
name: heart contraction
namespace: biological_process
def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
synonym: "cardiac contraction" RELATED []
synonym: "heart beating" EXACT []
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003015 ! heart process
relationship: BFO:0000050 GO:0008015 ! part of blood circulation

[Term]
id: GO:0060048
name: cardiac muscle contraction
namespace: biological_process
def: "Muscle contraction of cardiac muscle tissue." [GOC:dph]
synonym: "heart muscle contraction" EXACT []
is_a: GO:0006941 ! striated muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue
relationship: BFO:0000050 GO:0060047 ! part of heart contraction
relationship: BFO:0000066 UBERON:0001133 ! occurs in cardiac muscle tissue

[Term]
id: GO:0060089
name: molecular transducer activity
namespace: molecular_function
def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt]
subset: gocheck_do_not_annotate
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060092
name: regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060012 ! regulates synaptic transmission, glycinergic
relationship: RO:0002211 GO:0060012 ! regulates synaptic transmission, glycinergic

[Term]
id: GO:0060093
name: negative regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "negative regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060012 ! negatively regulates synaptic transmission, glycinergic
relationship: RO:0002212 GO:0060012 ! negatively regulates synaptic transmission, glycinergic

[Term]
id: GO:0060094
name: positive regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "positive regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060012 ! positively regulates synaptic transmission, glycinergic
relationship: RO:0002213 GO:0060012 ! positively regulates synaptic transmission, glycinergic

[Term]
id: GO:0060096
name: serotonin secretion, neurotransmission
namespace: biological_process
def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph]
synonym: "serotonin release, neurotransmission" RELATED [GOC:tb]
is_a: GO:0001820 ! serotonin secretion
is_a: GO:0007269 ! neurotransmitter secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:350546 ! has primary input

[Term]
id: GO:0060123
name: regulation of growth hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030252 ! regulates growth hormone secretion
relationship: RO:0002211 GO:0030252 ! regulates growth hormone secretion

[Term]
id: GO:0060124
name: positive regulation of growth hormone secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030252 ! positively regulates growth hormone secretion
relationship: RO:0002213 GO:0030252 ! positively regulates growth hormone secretion

[Term]
id: GO:0060125
name: negative regulation of growth hormone secretion
namespace: biological_process
def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030252 ! negatively regulates growth hormone secretion
relationship: RO:0002212 GO:0030252 ! negatively regulates growth hormone secretion

[Term]
id: GO:0060126
name: somatotropin secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell differentiation" EXACT []
synonym: "somatotrope differentiation" RELATED []
synonym: "somatotroph differentiation" RELATED []
synonym: "somatotrophin secreting cell differentiation" EXACT []
synonym: "somatotropic cell differentiation" RELATED []
synonym: "somatrophic cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000295 ! results in acquisition of features of somatotropin secreting cell
relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development
relationship: RO:0002315 CL:0000295 ! results in acquisition of features of somatotropin secreting cell

[Term]
id: GO:0060127
name: prolactin secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil differentiation" EXACT []
synonym: "lactotrope differentiation" EXACT []
synonym: "lactotroph differentiation" EXACT []
synonym: "lactotropic cell differentiation" EXACT []
synonym: "mammotrope differentiation" EXACT []
synonym: "mammotroph differentiation" EXACT []
synonym: "mammotrophic cell differentiation" EXACT []
synonym: "mammotropic cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000439 ! results in acquisition of features of prolactin secreting cell
relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development
relationship: RO:0002315 CL:0000439 ! results in acquisition of features of prolactin secreting cell

[Term]
id: GO:0060128
name: corticotropin hormone secreting cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT []
synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph]
synonym: "corticotrope differentiation" EXACT []
synonym: "corticotroph differentiation" EXACT []
synonym: "corticotrophin hormone secreting cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000467 ! results in acquisition of features of adrenocorticotropic hormone secreting cell
relationship: BFO:0000050 GO:0021984 ! part of adenohypophysis development
relationship: RO:0002315 CL:0000467 ! results in acquisition of features of adrenocorticotropic hormone secreting cell

[Term]
id: GO:0060131
name: corticotropin hormone secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell development" EXACT []
synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph]
synonym: "corticotrope development" EXACT []
synonym: "corticotroph development" RELATED []
synonym: "corticotrophin hormone secreting cell development" RELATED []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000467 ! results in development of adrenocorticotropic hormone secreting cell
relationship: BFO:0000050 GO:0060128 ! part of corticotropin hormone secreting cell differentiation
relationship: RO:0002296 CL:0000467 ! results in development of adrenocorticotropic hormone secreting cell

[Term]
id: GO:0060132
name: prolactin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil development" EXACT []
synonym: "lactotrope development" EXACT []
synonym: "lactotroph development" EXACT []
synonym: "lactotropic cell development" EXACT []
synonym: "mammotrope development" EXACT []
synonym: "mammotroph development" EXACT []
synonym: "mammotrophic cell development" EXACT []
synonym: "mammotropic cell development" EXACT []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000439 ! results in development of prolactin secreting cell
relationship: BFO:0000050 GO:0060127 ! part of prolactin secreting cell differentiation
relationship: RO:0002296 CL:0000439 ! results in development of prolactin secreting cell

[Term]
id: GO:0060133
name: somatotropin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell development" EXACT []
synonym: "somatotrope development" RELATED []
synonym: "somatotroph development" RELATED []
synonym: "somatotrophin secreting cell development" EXACT []
synonym: "somatotropic cell development" EXACT []
synonym: "somatrophic cell development" RELATED []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000295 ! results in development of somatotropin secreting cell
relationship: BFO:0000050 GO:0060126 ! part of somatotropin secreting cell differentiation
relationship: RO:0002296 CL:0000295 ! results in development of somatotropin secreting cell

[Term]
id: GO:0060136
name: embryonic process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
intersection_of: GO:0022414 ! reproductive process
intersection_of: BFO:0000050 GO:0007565 ! part of female pregnancy
intersection_of: BFO:0000050 GO:0009790 ! part of embryo development
relationship: BFO:0000050 GO:0007565 ! part of female pregnancy
relationship: BFO:0000050 GO:0009792 ! part of embryo development ending in birth or egg hatching

[Term]
id: GO:0060142
name: regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion
relationship: RO:0002211 GO:0000768 ! regulates syncytium formation by plasma membrane fusion

[Term]
id: GO:0060143
name: positive regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion
relationship: RO:0002213 GO:0000768 ! positively regulates syncytium formation by plasma membrane fusion

[Term]
id: GO:0060170
name: ciliary membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial membrane" EXACT []
synonym: "cilium membrane" EXACT []
synonym: "flagellar membrane" NARROW []
synonym: "flagellum membrane" NARROW []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0005929 ! bounding layer of cilium
relationship: RO:0002007 GO:0005929 ! bounding layer of cilium

[Term]
id: GO:0060173
name: limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378]
synonym: "limb bud development" NARROW [GOC:dph]
synonym: "paired limb/fin development" EXACT []
xref: Wikipedia:Limb_development
is_a: GO:0048736 ! appendage development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin
relationship: RO:0002296 UBERON:0004708 ! results in development of paired limb/fin

[Term]
id: GO:0060214
name: endocardium formation
namespace: biological_process
def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002165 ! results in formation of endocardium
relationship: BFO:0000050 GO:0003160 ! part of endocardium morphogenesis
relationship: RO:0002297 UBERON:0002165 ! results in formation of endocardium

[Term]
id: GO:0060218
name: hematopoietic stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]
synonym: "haematopoietic stem cell differentiation" EXACT []
synonym: "haemopoietic stem cell differentiation" EXACT []
synonym: "hemopoietic stem cell differentiation" EXACT []
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell
relationship: RO:0002315 CL:0000037 ! results in acquisition of features of hematopoietic stem cell

[Term]
id: GO:0060219
name: camera-type eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell
relationship: BFO:0000050 GO:0003407 ! part of neural retina development
relationship: BFO:0000050 GO:0060042 ! part of retina morphogenesis in camera-type eye
relationship: RO:0002315 CL:0010009 ! results in acquisition of features of camera-type eye photoreceptor cell

[Term]
id: GO:0060221
name: retinal rod cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell
relationship: RO:0002315 CL:0000604 ! results in acquisition of features of retinal rod cell

[Term]
id: GO:0060231
name: mesenchymal to epithelial transition
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000066 ! results in acquisition of features of epithelial cell
intersection_of: RO:0004009 CL:0008019 ! has primary input mesenchymal cell
relationship: RO:0004009 CL:0008019 ! has primary input mesenchymal cell

[Term]
id: GO:0060249
name: anatomical structure homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph]
synonym: "anatomical structure maintenance" EXACT [GOC:dph]
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0060251
name: regulation of glial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014009 ! regulates glial cell proliferation
relationship: RO:0002211 GO:0014009 ! regulates glial cell proliferation

[Term]
id: GO:0060252
name: positive regulation of glial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation
relationship: RO:0002213 GO:0014009 ! positively regulates glial cell proliferation

[Term]
id: GO:0060253
name: negative regulation of glial cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation
relationship: RO:0002212 GO:0014009 ! negatively regulates glial cell proliferation

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
subset: gocheck_do_not_annotate
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process
relationship: RO:0002211 GO:0043170 ! regulates macromolecule metabolic process

[Term]
id: GO:0060263
name: regulation of respiratory burst
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045730 ! regulates respiratory burst
relationship: RO:0002211 GO:0045730 ! regulates respiratory burst

[Term]
id: GO:0060271
name: cilium assembly
namespace: biological_process
def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliogenesis" EXACT []
synonym: "cilium biogenesis" RELATED [GOC:mah]
synonym: "cilium formation" EXACT []
synonym: "cilium morphogenesis" RELATED []
synonym: "cilium organization" RELATED [GOC:dph]
synonym: "microtubule-based flagellum assembly" EXACT []
xref: Reactome:R-HSA-5617833 "Cilium Assembly"
is_a: GO:0044782 ! cilium organization
is_a: GO:0070925 ! organelle assembly
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005929 ! results in assembly of cilium
relationship: BFO:0000051 GO:0035082 ! has part axoneme assembly
relationship: BFO:0000051 GO:0035735 ! has part intraciliary transport involved in cilium assembly
relationship: BFO:0000051 GO:0061512 ! has part protein localization to cilium
relationship: BFO:0000051 GO:0097712 ! has part vesicle targeting, trans-Golgi to periciliary membrane compartment
relationship: BFO:0000051 GO:1905349 ! has part ciliary transition zone assembly
relationship: RO:0002224 GO:0097711 ! starts with ciliary basal body-plasma membrane docking
relationship: RO:0002588 GO:0005929 ! results in assembly of cilium

[Term]
id: GO:0060281
name: regulation of oocyte development
namespace: biological_process
def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318]
is_a: GO:1905879 ! regulation of oogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048599 ! regulates oocyte development
relationship: RO:0002211 GO:0048599 ! regulates oocyte development

[Term]
id: GO:0060282
name: positive regulation of oocyte development
namespace: biological_process
def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048599 ! positively regulates oocyte development
relationship: RO:0002213 GO:0048599 ! positively regulates oocyte development

[Term]
id: GO:0060283
name: negative regulation of oocyte development
namespace: biological_process
def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048599 ! negatively regulates oocyte development
relationship: RO:0002212 GO:0048599 ! negatively regulates oocyte development

[Term]
id: GO:0060284
name: regulation of cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048468 ! regulates cell development
relationship: RO:0002211 GO:0048468 ! regulates cell development

[Term]
id: GO:0060285
name: cilium-dependent cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent.
synonym: "ciliary cell motility" RELATED []
synonym: "cilium cell motility" EXACT []
synonym: "microtubule-based flagellar cell motility" EXACT []
is_a: GO:0001539 ! cilium or flagellum-dependent cell motility
relationship: BFO:0000051 GO:0003341 ! has part cilium movement

[Term]
id: GO:0060294
name: cilium movement involved in cell motility
namespace: biological_process
def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
intersection_of: GO:0003341 ! cilium movement
intersection_of: BFO:0000050 GO:0048870 ! part of cell motility
relationship: BFO:0000050 GO:0060285 ! part of cilium-dependent cell motility

[Term]
id: GO:0060295
name: regulation of cilium movement involved in cell motility
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060294 ! regulates cilium movement involved in cell motility
relationship: RO:0002211 GO:0060294 ! regulates cilium movement involved in cell motility

[Term]
id: GO:0060297
name: regulation of sarcomere organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0110020 ! regulation of actomyosin structure organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045214 ! regulates sarcomere organization
relationship: RO:0002211 GO:0045214 ! regulates sarcomere organization

[Term]
id: GO:0060298
name: positive regulation of sarcomere organization
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045214 ! positively regulates sarcomere organization
relationship: RO:0002213 GO:0045214 ! positively regulates sarcomere organization

[Term]
id: GO:0060299
name: negative regulation of sarcomere organization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization
relationship: RO:0002212 GO:0045214 ! negatively regulates sarcomere organization

[Term]
id: GO:0060322
name: head development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000033 ! results in development of head
relationship: RO:0002296 UBERON:0000033 ! results in development of head

[Term]
id: GO:0060323
name: head morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000033 ! results in morphogenesis of head
relationship: BFO:0000050 GO:0010171 ! part of body morphogenesis
relationship: BFO:0000050 GO:0060322 ! part of head development
relationship: RO:0002298 UBERON:0000033 ! results in morphogenesis of head

[Term]
id: GO:0060324
name: face development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001456 ! results in development of face
relationship: BFO:0000050 GO:0060322 ! part of head development
relationship: RO:0002296 UBERON:0001456 ! results in development of face

[Term]
id: GO:0060325
name: face morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001456 ! results in morphogenesis of face
relationship: BFO:0000050 GO:0060323 ! part of head morphogenesis
relationship: BFO:0000050 GO:0060324 ! part of face development
relationship: RO:0002298 UBERON:0001456 ! results in morphogenesis of face

[Term]
id: GO:0060326
name: cell chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]
xref: Reactome:R-HSA-9664424 "Cell recruitment (pro-inflammatory response)"
is_a: GO:0006935 ! chemotaxis
is_a: GO:0016477 ! cell migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000000 ! results in movement of cell
relationship: BFO:0000050 GO:0070887 ! part of cellular response to chemical stimulus
relationship: RO:0002565 CL:0000000 ! results in movement of cell

[Term]
id: GO:0060341
name: regulation of cellular localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cellular localisation" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051641 ! regulates cellular localization
relationship: RO:0002211 GO:0051641 ! regulates cellular localization

[Term]
id: GO:0060348
name: bone development
namespace: biological_process
def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048513 ! animal organ development
intersection_of: RO:0002296 UBERON:0001474 ! results in development of bone element
relationship: BFO:0000050 GO:0001501 ! part of skeletal system development
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002296 UBERON:0001474 ! results in development of bone element

[Term]
id: GO:0060349
name: bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element
relationship: BFO:0000050 GO:0048705 ! part of skeletal system morphogenesis
relationship: BFO:0000050 GO:0060348 ! part of bone development
relationship: RO:0002298 UBERON:0001474 ! results in morphogenesis of bone element

[Term]
id: GO:0060350
name: endochondral bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone
relationship: RO:0002298 UBERON:0002513 ! results in morphogenesis of endochondral bone

[Term]
id: GO:0060351
name: cartilage development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph]
is_a: GO:0051216 ! cartilage development
intersection_of: GO:0051216 ! cartilage development
intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis
relationship: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis

[Term]
id: GO:0060363
name: cranial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl]
is_a: GO:0097094 ! craniofacial suture morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003685 ! results in morphogenesis of cranial suture
relationship: RO:0002298 UBERON:0003685 ! results in morphogenesis of cranial suture

[Term]
id: GO:0060379
name: cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb]
synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb]
synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation
is_a: GO:0045445 ! myoblast differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast
relationship: RO:0002315 CL:0000513 ! results in acquisition of features of cardiac muscle myoblast

[Term]
id: GO:0060404
name: axonemal microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010938 ! cytoplasmic microtubule depolymerization
is_a: GO:0061523 ! cilium disassembly
intersection_of: GO:0007019 ! microtubule depolymerization
intersection_of: BFO:0000066 GO:0005930 ! occurs in axoneme
relationship: BFO:0000066 GO:0005930 ! occurs in axoneme

[Term]
id: GO:0060408
name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process
relationship: RO:0002211 GO:0008291 ! regulates acetylcholine metabolic process

[Term]
id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process
relationship: RO:0002213 GO:0008291 ! positively regulates acetylcholine metabolic process

[Term]
id: GO:0060411
name: cardiac septum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]
synonym: "heart septum morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum
relationship: BFO:0000050 GO:0003206 ! part of cardiac chamber morphogenesis
relationship: BFO:0000050 GO:0003279 ! part of cardiac septum development
relationship: RO:0002298 UBERON:0002099 ! results in morphogenesis of cardiac septum

[Term]
id: GO:0060412
name: ventricular septum morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph]
synonym: "interventricular septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum
relationship: BFO:0000050 GO:0003281 ! part of ventricular septum development
relationship: RO:0002298 UBERON:0002094 ! results in morphogenesis of interventricular septum

[Term]
id: GO:0060413
name: atrial septum morphogenesis
namespace: biological_process
def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart]
synonym: "interatrial septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum
relationship: BFO:0000050 GO:0003209 ! part of cardiac atrium morphogenesis
relationship: BFO:0000050 GO:0003283 ! part of atrial septum development
relationship: RO:0002298 UBERON:0002085 ! results in morphogenesis of interatrial septum

[Term]
id: GO:0060414
name: aorta smooth muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue
relationship: BFO:0000050 GO:0035909 ! part of aorta morphogenesis
relationship: BFO:0000050 GO:0048745 ! part of smooth muscle tissue development
relationship: RO:0002298 UBERON:0004178 ! results in morphogenesis of aorta smooth muscle tissue

[Term]
id: GO:0060415
name: muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0048729 ! tissue morphogenesis
intersection_of: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue
relationship: BFO:0000050 GO:0048644 ! part of muscle organ morphogenesis
relationship: RO:0002298 UBERON:0002385 ! results in morphogenesis of muscle tissue

[Term]
id: GO:0060419
name: heart growth
namespace: biological_process
def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0035265 ! organ growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0000948 ! results in growth of heart
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002343 UBERON:0000948 ! results in growth of heart

[Term]
id: GO:0060420
name: regulation of heart growth
namespace: biological_process
def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060419 ! regulates heart growth
relationship: RO:0002211 GO:0060419 ! regulates heart growth

[Term]
id: GO:0060421
name: positive regulation of heart growth
namespace: biological_process
def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0046622 ! positive regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060419 ! positively regulates heart growth
relationship: RO:0002213 GO:0060419 ! positively regulates heart growth

[Term]
id: GO:0060425
name: lung morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung
relationship: BFO:0000050 GO:0030324 ! part of lung development
relationship: RO:0002298 UBERON:0002048 ! results in morphogenesis of lung

[Term]
id: GO:0060426
name: lung vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0001944 ! vasculature development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000102 ! results in development of lung vasculature
relationship: BFO:0000050 GO:0030324 ! part of lung development
relationship: RO:0002296 UBERON:0000102 ! results in development of lung vasculature

[Term]
id: GO:0060427
name: lung connective tissue development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary connective tissue development" EXACT []
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue
relationship: BFO:0000050 GO:0030324 ! part of lung development
relationship: RO:0002296 UBERON:0000114 ! results in development of lung connective tissue

[Term]
id: GO:0060428
name: lung epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000115 ! results in development of lung epithelium
relationship: BFO:0000050 GO:0030324 ! part of lung development
relationship: RO:0002296 UBERON:0000115 ! results in development of lung epithelium

[Term]
id: GO:0060429
name: epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]
subset: goslim_drosophila
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000483 ! results in development of epithelium
relationship: RO:0002296 UBERON:0000483 ! results in development of epithelium

[Term]
id: GO:0060431
name: primary lung bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung]
synonym: "lung formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! animal organ formation
is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis
is_a: GO:0060572 ! morphogenesis of an epithelial bud
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0002048 ! results in formation of lung
relationship: RO:0002297 UBERON:0002048 ! results in formation of lung

[Term]
id: GO:0060433
name: bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0030323 ! respiratory tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002185 ! results in development of bronchus
relationship: BFO:0000050 GO:0060541 ! part of respiratory system development
relationship: RO:0002296 UBERON:0002185 ! results in development of bronchus

[Term]
id: GO:0060434
name: bronchus morphogenesis
namespace: biological_process
def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus
relationship: BFO:0000050 GO:0060433 ! part of bronchus development
relationship: RO:0002298 UBERON:0002185 ! results in morphogenesis of bronchus

[Term]
id: GO:0060437
name: lung growth
namespace: biological_process
def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph]
is_a: GO:0035265 ! organ growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0002048 ! results in growth of lung
relationship: BFO:0000050 GO:0030324 ! part of lung development
relationship: RO:0002343 UBERON:0002048 ! results in growth of lung

[Term]
id: GO:0060438
name: trachea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001005 ! results in development of respiratory airway
relationship: BFO:0000050 GO:0060541 ! part of respiratory system development
relationship: RO:0002296 UBERON:0001005 ! results in development of respiratory airway

[Term]
id: GO:0060439
name: trachea morphogenesis
namespace: biological_process
def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway
relationship: BFO:0000050 GO:0060438 ! part of trachea development
relationship: RO:0002298 UBERON:0001005 ! results in morphogenesis of respiratory airway

[Term]
id: GO:0060440
name: trachea formation
namespace: biological_process
def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048645 ! animal organ formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001005 ! results in formation of respiratory airway
relationship: BFO:0000050 GO:0060439 ! part of trachea morphogenesis
relationship: RO:0002297 UBERON:0001005 ! results in formation of respiratory airway

[Term]
id: GO:0060441
name: epithelial tube branching involved in lung morphogenesis
namespace: biological_process
def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung]
synonym: "lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: BFO:0000050 GO:0060425 ! part of lung morphogenesis
relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis

[Term]
id: GO:0060452
name: positive regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb]
is_a: GO:0045823 ! positive regulation of heart contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction
relationship: RO:0002213 GO:0060048 ! positively regulates cardiac muscle contraction

[Term]
id: GO:0060456
name: positive regulation of digestive system process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0022600 ! positively regulates digestive system process
relationship: RO:0002213 GO:0022600 ! positively regulates digestive system process

[Term]
id: GO:0060457
name: negative regulation of digestive system process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0022600 ! negatively regulates digestive system process
relationship: RO:0002212 GO:0022600 ! negatively regulates digestive system process

[Term]
id: GO:0060458
name: right lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0030324 ! lung development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002167 ! results in development of right lung
relationship: RO:0002296 UBERON:0002167 ! results in development of right lung

[Term]
id: GO:0060459
name: left lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "left pulmonary development" EXACT [GOC:dph]
is_a: GO:0030324 ! lung development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002168 ! results in development of left lung
relationship: RO:0002296 UBERON:0002168 ! results in development of left lung

[Term]
id: GO:0060460
name: left lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph]
is_a: GO:0060425 ! lung morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung
relationship: BFO:0000050 GO:0060459 ! part of left lung development
relationship: RO:0002298 UBERON:0002168 ! results in morphogenesis of left lung

[Term]
id: GO:0060461
name: right lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060425 ! lung morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung
relationship: BFO:0000050 GO:0060458 ! part of right lung development
relationship: RO:0002298 UBERON:0002167 ! results in morphogenesis of right lung

[Term]
id: GO:0060465
name: pharynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk]
synonym: "pharyngeal development" RELATED []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0006562 ! results in development of pharynx
relationship: BFO:0000050 GO:0048565 ! part of digestive tract development
relationship: RO:0002296 UBERON:0006562 ! results in development of pharynx

[Term]
id: GO:0060467
name: negative regulation of fertilization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph]
is_a: GO:0080154 ! regulation of fertilization
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009566 ! negatively regulates fertilization
relationship: RO:0002212 GO:0009566 ! negatively regulates fertilization

[Term]
id: GO:0060468
name: prevention of polyspermy
namespace: biological_process
def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph]
synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph]
synonym: "polyspermy block" EXACT [GOC:dph]
is_a: GO:0060467 ! negative regulation of fertilization
intersection_of: GO:0060467 ! negative regulation of fertilization
intersection_of: BFO:0000050 GO:0007343 ! part of egg activation
relationship: BFO:0000050 GO:0007343 ! part of egg activation

[Term]
id: GO:0060479
name: lung cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: BFO:0000050 GO:0030324 ! part of lung development

[Term]
id: GO:0060485
name: mesenchyme development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph]
synonym: "mesenchymal development" EXACT [GOC:dph]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003104 ! results in development of mesenchyme
relationship: BFO:0000050 GO:0048513 ! part of animal organ development
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 UBERON:0003104 ! results in development of mesenchyme

[Term]
id: GO:0060487
name: lung epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph]
synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060479 ! lung cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung
relationship: BFO:0000050 GO:0060428 ! part of lung epithelium development
relationship: RO:0002315 CL:0000082 ! results in acquisition of features of epithelial cell of lung

[Term]
id: GO:0060491
name: regulation of cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb]
synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030031 ! regulates cell projection assembly
relationship: RO:0002211 GO:0030031 ! regulates cell projection assembly

[Term]
id: GO:0060495
name: cell-cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung]
synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: BFO:0000050 GO:0030324 ! part of lung development
relationship: BFO:0000050 GO:0030324 ! part of lung development

[Term]
id: GO:0060496
name: mesenchymal-epithelial cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: BFO:0000050 GO:0030324 ! part of lung development

[Term]
id: GO:0060497
name: mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph]
synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell
intersection_of: RO:0002232 CL:0000223 ! has end location endodermal cell
relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell
relationship: RO:0002232 CL:0000223 ! has end location endodermal cell

[Term]
id: GO:0060501
name: positive regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis
relationship: RO:0002213 GO:0060502 ! positively regulates epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:0060502
name: epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: BFO:0000050 GO:0060425 ! part of lung morphogenesis
relationship: BFO:0000050 GO:0060425 ! part of lung morphogenesis
relationship: BFO:0000050 GO:0060428 ! part of lung epithelium development

[Term]
id: GO:0060532
name: bronchus cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cartilage development" EXACT []
is_a: GO:0051216 ! cartilage development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus
relationship: BFO:0000050 GO:0060433 ! part of bronchus development
relationship: RO:0002296 UBERON:0001956 ! results in development of cartilage of bronchus
creation_date: 2009-04-10T08:12:06Z

[Term]
id: GO:0060533
name: bronchus cartilage morphogenesis
namespace: biological_process
def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus
relationship: BFO:0000050 GO:0060434 ! part of bronchus morphogenesis
relationship: BFO:0000050 GO:0060532 ! part of bronchus cartilage development
relationship: RO:0002298 UBERON:0001956 ! results in morphogenesis of cartilage of bronchus
creation_date: 2009-04-10T08:47:41Z

[Term]
id: GO:0060534
name: trachea cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051216 ! cartilage development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage
relationship: BFO:0000050 GO:0060438 ! part of trachea development
relationship: RO:0002296 UBERON:0003604 ! results in development of trachea cartilage
creation_date: 2009-04-10T09:00:18Z

[Term]
id: GO:0060535
name: trachea cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage
relationship: BFO:0000050 GO:0060439 ! part of trachea morphogenesis
relationship: BFO:0000050 GO:0060534 ! part of trachea cartilage development
relationship: RO:0002298 UBERON:0003604 ! results in morphogenesis of trachea cartilage
creation_date: 2009-04-10T09:07:48Z

[Term]
id: GO:0060536
name: cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element
relationship: BFO:0000050 GO:0051216 ! part of cartilage development
relationship: RO:0002298 UBERON:0007844 ! results in morphogenesis of cartilage element
creation_date: 2009-04-10T09:13:27Z

[Term]
id: GO:0060537
name: muscle tissue development
namespace: biological_process
def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002385 ! results in development of muscle tissue
relationship: RO:0002296 UBERON:0002385 ! results in development of muscle tissue
creation_date: 2009-04-10T08:05:37Z

[Term]
id: GO:0060538
name: skeletal muscle organ development
namespace: biological_process
def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]
is_a: GO:0007517 ! muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0002296 UBERON:0014892 ! results in development of skeletal muscle organ, vertebrate
creation_date: 2009-04-10T08:25:12Z

[Term]
id: GO:0060539
name: diaphragm development
namespace: biological_process
def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph]
is_a: GO:0060538 ! skeletal muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001103 ! results in development of diaphragm
relationship: BFO:0000050 GO:0060541 ! part of respiratory system development
relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia
relationship: RO:0002296 UBERON:0001103 ! results in development of diaphragm
creation_date: 2009-04-10T08:44:56Z

[Term]
id: GO:0060540
name: diaphragm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph]
is_a: GO:0048644 ! muscle organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm
relationship: BFO:0000050 GO:0060539 ! part of diaphragm development
relationship: RO:0002298 UBERON:0001103 ! results in morphogenesis of diaphragm
creation_date: 2009-04-10T08:47:51Z

[Term]
id: GO:0060541
name: respiratory system development
namespace: biological_process
def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]
subset: goslim_drosophila
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001004 ! results in development of respiratory system
relationship: RO:0002296 UBERON:0001004 ! results in development of respiratory system
creation_date: 2009-04-10T08:55:42Z

[Term]
id: GO:0060560
name: developmental growth involved in morphogenesis
namespace: biological_process
def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]
synonym: "differential growth" EXACT [GOC:dph]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis
relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis
created_by: dph
creation_date: 2009-04-28T08:42:53Z

[Term]
id: GO:0060561
name: apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in development" RELATED []
synonym: "apoptosis involved in morphogenesis" NARROW []
synonym: "morphogenetic apoptosis" RELATED [GOC:dph]
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis
relationship: BFO:0000050 GO:0009653 ! part of anatomical structure morphogenesis
creation_date: 2009-04-28T09:17:27Z

[Term]
id: GO:0060562
name: epithelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube
relationship: RO:0002298 UBERON:0003914 ! results in morphogenesis of epithelial tube
creation_date: 2009-04-28T09:33:36Z

[Term]
id: GO:0060563
name: neuroepithelial cell differentiation
namespace: biological_process
def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell
relationship: RO:0002315 CL:0000710 ! results in acquisition of features of neurecto-epithelial cell
creation_date: 2009-04-29T01:50:05Z

[Term]
id: GO:0060571
name: morphogenesis of an epithelial fold
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph]
synonym: "epithelial folding" EXACT [GOC:dph]
synonym: "folding of an epithelial sheet" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold
relationship: RO:0002298 UBERON:0005157 ! results in morphogenesis of epithelial fold
creation_date: 2009-04-30T09:27:17Z

[Term]
id: GO:0060572
name: morphogenesis of an epithelial bud
namespace: biological_process
def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud
relationship: RO:0002298 UBERON:0005153 ! results in morphogenesis of epithelial bud
creation_date: 2009-04-30T09:38:35Z

[Term]
id: GO:0060577
name: pulmonary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph]
synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein
relationship: RO:0002298 UBERON:0002016 ! results in morphogenesis of pulmonary vein
creation_date: 2009-05-06T08:44:04Z

[Term]
id: GO:0060578
name: superior vena cava morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava
relationship: RO:0002298 UBERON:0001585 ! results in morphogenesis of anterior vena cava
creation_date: 2009-05-06T08:47:21Z

[Term]
id: GO:0060581
name: cell fate commitment involved in pattern specification
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
intersection_of: GO:0045165 ! cell fate commitment
intersection_of: BFO:0000050 GO:0007389 ! part of pattern specification process
relationship: BFO:0000050 GO:0007389 ! part of pattern specification process
creation_date: 2009-05-07T12:40:55Z

[Term]
id: GO:0060591
name: chondroblast differentiation
namespace: biological_process
def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph]
synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast
relationship: BFO:0000050 GO:0051216 ! part of cartilage development
relationship: RO:0002315 CL:0000058 ! results in acquisition of features of chondroblast
creation_date: 2009-05-11T07:47:36Z

[Term]
id: GO:0060612
name: adipose tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph]
synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001013 ! results in development of adipose tissue
relationship: BFO:0000050 GO:0048513 ! part of animal organ development
relationship: RO:0002296 UBERON:0001013 ! results in development of adipose tissue
creation_date: 2009-05-15T12:36:28Z

[Term]
id: GO:0060623
name: regulation of chromosome condensation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030261 ! regulates chromosome condensation
relationship: RO:0002211 GO:0030261 ! regulates chromosome condensation
creation_date: 2009-05-18T02:12:13Z

[Term]
id: GO:0060627
name: regulation of vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport
relationship: RO:0002211 GO:0016192 ! regulates vesicle-mediated transport
created_by: dph
creation_date: 2009-05-18T02:29:43Z

[Term]
id: GO:0060631
name: regulation of meiosis I
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0040020 ! regulation of meiotic nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007127 ! regulates meiosis I
relationship: RO:0002211 GO:0007127 ! regulates meiosis I
created_by: dph
creation_date: 2009-05-18T02:55:19Z

[Term]
id: GO:0060632
name: regulation of microtubule-based movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007018 ! regulates microtubule-based movement
relationship: RO:0002211 GO:0007018 ! regulates microtubule-based movement
creation_date: 2009-05-18T03:07:02Z

[Term]
id: GO:0060638
name: mesenchymal-epithelial cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph]
synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0008019 ! has start location mesenchymal cell
intersection_of: RO:0002232 CL:0000066 ! has end location epithelial cell
relationship: RO:0002231 CL:0008019 ! has start location mesenchymal cell
relationship: RO:0002232 CL:0000066 ! has end location epithelial cell
creation_date: 2009-05-19T03:59:05Z

[Term]
id: GO:0060684
name: epithelial-mesenchymal cell signaling
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000066 ! has start location epithelial cell
intersection_of: RO:0002232 CL:0008019 ! has end location mesenchymal cell
relationship: RO:0002231 CL:0000066 ! has start location epithelial cell
relationship: RO:0002232 CL:0008019 ! has end location mesenchymal cell
creation_date: 2009-06-03T06:36:46Z

[Term]
id: GO:0060688
name: regulation of morphogenesis of a branching structure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure
relationship: RO:0002211 GO:0001763 ! regulates morphogenesis of a branching structure
creation_date: 2009-06-05T12:41:44Z

[Term]
id: GO:0060759
name: regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034097 ! regulates response to cytokine
relationship: RO:0002211 GO:0034097 ! regulates response to cytokine
creation_date: 2009-06-22T02:56:12Z

[Term]
id: GO:0060760
name: positive regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034097 ! positively regulates response to cytokine
relationship: RO:0002213 GO:0034097 ! positively regulates response to cytokine
creation_date: 2009-06-22T02:58:04Z

[Term]
id: GO:0060761
name: negative regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034097 ! negatively regulates response to cytokine
relationship: RO:0002212 GO:0034097 ! negatively regulates response to cytokine
creation_date: 2009-06-22T02:59:57Z

[Term]
id: GO:0060784
name: regulation of cell proliferation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0042127 ! regulation of cell population proliferation
intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis
relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue
creation_date: 2009-07-31T01:46:28Z

[Term]
id: GO:0060785
name: regulation of apoptosis involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0042981 ! regulation of apoptotic process
intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis
relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue
creation_date: 2009-07-31T01:49:54Z

[Term]
id: GO:0060786
name: regulation of cell differentiation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0045595 ! regulation of cell differentiation
intersection_of: BFO:0000050 GO:0001894 ! part of tissue homeostasis
relationship: BFO:0000050 GO:0048873 ! part of homeostasis of number of cells within a tissue
creation_date: 2009-07-31T01:55:19Z

[Term]
id: GO:0060788
name: ectodermal placode formation
namespace: biological_process
def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0005085 ! results in formation of ectodermal placode
relationship: BFO:0000050 GO:0071697 ! part of ectodermal placode morphogenesis
relationship: RO:0002297 UBERON:0005085 ! results in formation of ectodermal placode
creation_date: 2009-08-04T12:15:57Z

[Term]
id: GO:0060795
name: cell fate commitment involved in formation of primary germ layer
namespace: biological_process
def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
intersection_of: GO:0045165 ! cell fate commitment
intersection_of: BFO:0000050 GO:0001704 ! part of formation of primary germ layer
relationship: BFO:0000050 GO:0001704 ! part of formation of primary germ layer
creation_date: 2009-08-04T03:11:22Z

[Term]
id: GO:0060837
name: blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell
relationship: BFO:0000050 GO:0001568 ! part of blood vessel development
relationship: RO:0002315 CL:0000071 ! results in acquisition of features of blood vessel endothelial cell
creation_date: 2009-08-11T03:47:36Z

[Term]
id: GO:0060840
name: artery development
namespace: biological_process
def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001637 ! results in development of artery
relationship: RO:0002296 UBERON:0001637 ! results in development of artery
creation_date: 2009-08-12T10:10:51Z

[Term]
id: GO:0060841
name: venous blood vessel development
namespace: biological_process
def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001638 ! results in development of vein
relationship: RO:0002296 UBERON:0001638 ! results in development of vein
creation_date: 2009-08-12T10:14:07Z

[Term]
id: GO:0060842
name: arterial endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery
relationship: RO:0002315 CL:1000413 ! results in acquisition of features of endothelial cell of artery
creation_date: 2009-08-12T10:41:34Z

[Term]
id: GO:0060843
name: venous endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell
relationship: RO:0002315 CL:0002543 ! results in acquisition of features of vein endothelial cell
creation_date: 2009-08-12T10:43:40Z

[Term]
id: GO:0060896
name: neural plate pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb]
xref: Reactome:R-HSA-9834899 "Specification of the neural plate border"
is_a: GO:0007389 ! pattern specification process
creation_date: 2009-08-13T02:06:27Z

[Term]
id: GO:0060897
name: neural plate regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060896 ! neural plate pattern specification
creation_date: 2009-08-13T02:09:04Z

[Term]
id: GO:0060900
name: embryonic camera-type eye formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: BFO:0000050 GO:0048596 ! part of embryonic camera-type eye morphogenesis
creation_date: 2009-08-13T02:26:54Z

[Term]
id: GO:0060907
name: positive regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb]
is_a: GO:0010935 ! regulation of macrophage cytokine production
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010934 ! positively regulates macrophage cytokine production
relationship: RO:0002213 GO:0010934 ! positively regulates macrophage cytokine production
creation_date: 2009-09-04T02:32:18Z

[Term]
id: GO:0060914
name: heart formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "cardiogenesis" RELATED [GOC:mtg_heart]
xref: Reactome:R-HSA-9733709 "Cardiogenesis"
is_a: GO:0048645 ! animal organ formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000948 ! results in formation of heart
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: RO:0002297 UBERON:0000948 ! results in formation of heart
creation_date: 2009-09-17T09:02:13Z

[Term]
id: GO:0060915
name: mesenchymal cell differentiation involved in lung development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: BFO:0000050 GO:0030324 ! part of lung development
relationship: BFO:0000050 GO:0030324 ! part of lung development
creation_date: 2009-09-18T11:45:33Z

[Term]
id: GO:0060916
name: mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph]
is_a: GO:0010463 ! mesenchymal cell proliferation
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: BFO:0000050 GO:0030324 ! part of lung development
relationship: BFO:0000050 GO:0030324 ! part of lung development
creation_date: 2009-09-18T11:50:17Z

[Term]
id: GO:0060920
name: cardiac pacemaker cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell differentiation" BROAD []
is_a: GO:0055007 ! cardiac muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte
relationship: RO:0002315 CL:0002072 ! results in acquisition of features of nodal myocyte
creation_date: 2009-09-29T11:01:31Z

[Term]
id: GO:0060921
name: sinoatrial node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart]
synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node
relationship: BFO:0000050 GO:0003163 ! part of sinoatrial node development
relationship: RO:0002315 CL:1000409 ! results in acquisition of features of myocyte of sinoatrial node
creation_date: 2009-09-29T11:03:30Z

[Term]
id: GO:0060922
name: atrioventricular node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart]
synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart]
is_a: GO:0003292 ! cardiac septum cell differentiation
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node
relationship: BFO:0000050 GO:0003162 ! part of atrioventricular node development
relationship: RO:0002315 CL:1000410 ! results in acquisition of features of myocyte of atrioventricular node
creation_date: 2009-09-29T11:07:06Z

[Term]
id: GO:0060926
name: cardiac pacemaker cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell development" BROAD []
is_a: GO:0055013 ! cardiac muscle cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 CL:0002072 ! results in development of nodal myocyte
relationship: BFO:0000050 GO:0060920 ! part of cardiac pacemaker cell differentiation
relationship: RO:0002296 CL:0002072 ! results in development of nodal myocyte
creation_date: 2009-09-29T11:51:55Z

[Term]
id: GO:0060928
name: atrioventricular node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "AV node cell development" EXACT [GOC:mtg_heart]
is_a: GO:0060926 ! cardiac pacemaker cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node
relationship: BFO:0000050 GO:0060922 ! part of atrioventricular node cell differentiation
relationship: RO:0002296 CL:1000410 ! results in development of myocyte of atrioventricular node
creation_date: 2009-09-29T11:59:26Z

[Term]
id: GO:0060931
name: sinoatrial node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell development" EXACT [GOC:mtg_heart]
synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060926 ! cardiac pacemaker cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node
relationship: BFO:0000050 GO:0060921 ! part of sinoatrial node cell differentiation
relationship: RO:0002296 CL:1000409 ! results in development of myocyte of sinoatrial node
creation_date: 2009-09-29T12:05:47Z

[Term]
id: GO:0060932
name: His-Purkinje system cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055007 ! cardiac muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell
relationship: BFO:0000050 GO:0003164 ! part of His-Purkinje system development
relationship: RO:0002315 CL:0010007 ! results in acquisition of features of His-Purkinje system cell
creation_date: 2009-09-29T01:10:32Z

[Term]
id: GO:0060933
name: His-Purkinje system cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell
relationship: BFO:0000050 GO:0060932 ! part of His-Purkinje system cell differentiation
relationship: RO:0002296 CL:0010007 ! results in development of His-Purkinje system cell
creation_date: 2009-09-29T01:15:02Z

[Term]
id: GO:0060935
name: cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue
relationship: RO:0002315 CL:0002548 ! results in acquisition of features of fibroblast of cardiac tissue
creation_date: 2009-09-29T01:20:04Z

[Term]
id: GO:0060936
name: cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue
relationship: BFO:0000050 GO:0060935 ! part of cardiac fibroblast cell differentiation
relationship: RO:0002296 CL:0002548 ! results in development of fibroblast of cardiac tissue
creation_date: 2009-09-29T01:23:03Z

[Term]
id: GO:0060945
name: cardiac neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0048934 ! peripheral nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron
relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development
relationship: RO:0002315 CL:0010022 ! results in acquisition of features of cardiac neuron
creation_date: 2009-09-29T02:45:33Z

[Term]
id: GO:0060946
name: cardiac blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell
relationship: RO:0002315 CL:0010006 ! results in acquisition of features of cardiac blood vessel endothelial cell
creation_date: 2009-09-29T02:48:55Z

[Term]
id: GO:0060950
name: cardiac glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell
relationship: RO:0002315 CL:0010020 ! results in acquisition of features of cardiac glial cell
creation_date: 2009-09-29T03:06:37Z

[Term]
id: GO:0060952
name: cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart]
is_a: GO:0021782 ! glial cell development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0010020 ! results in development of cardiac glial cell
relationship: BFO:0000050 GO:0060950 ! part of cardiac glial cell differentiation
relationship: RO:0002296 CL:0010020 ! results in development of cardiac glial cell
creation_date: 2009-09-29T03:09:24Z

[Term]
id: GO:0060956
name: endocardial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell
relationship: BFO:0000050 GO:0003157 ! part of endocardium development
relationship: RO:0002315 CL:0002350 ! results in acquisition of features of endocardial cell
creation_date: 2009-09-29T03:20:39Z

[Term]
id: GO:0060958
name: endocardial cell development
namespace: biological_process
def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0001885 ! endothelial cell development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 CL:0002350 ! results in development of endocardial cell
relationship: BFO:0000050 GO:0060956 ! part of endocardial cell differentiation
relationship: RO:0002296 CL:0002350 ! results in development of endocardial cell
creation_date: 2009-09-29T03:26:59Z

[Term]
id: GO:0060959
name: cardiac neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart neuron development" EXACT [GOC:mtg_heart]
is_a: GO:0048935 ! peripheral nervous system neuron development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0010022 ! results in development of cardiac neuron
relationship: BFO:0000050 GO:0060945 ! part of cardiac neuron differentiation
relationship: RO:0002296 CL:0010022 ! results in development of cardiac neuron
creation_date: 2009-09-30T10:14:56Z

[Term]
id: GO:0060973
name: cell migration involved in heart development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0007507 ! part of heart development
relationship: BFO:0000050 GO:0007507 ! part of heart development
creation_date: 2009-10-06T10:53:49Z

[Term]
id: GO:0060974
name: cell migration involved in heart formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0060914 ! part of heart formation
relationship: BFO:0000050 GO:0060914 ! part of heart formation
creation_date: 2009-10-06T10:56:33Z

[Term]
id: GO:0060976
name: coronary vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart vasculature development" EXACT [GOC:mtg_heart]
is_a: GO:0001568 ! blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel
relationship: BFO:0000050 GO:0007507 ! part of heart development
relationship: RO:0002296 UBERON:0003498 ! results in development of heart blood vessel
creation_date: 2009-10-06T12:15:23Z

[Term]
id: GO:0060977
name: coronary vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart]
synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel
relationship: BFO:0000050 GO:0060976 ! part of coronary vasculature development
relationship: RO:0002298 UBERON:0003498 ! results in morphogenesis of heart blood vessel
creation_date: 2009-10-06T12:28:23Z

[Term]
id: GO:0060978
name: angiogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart]
synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001525 ! angiogenesis
intersection_of: GO:0001525 ! angiogenesis
intersection_of: BFO:0000050 GO:0060976 ! part of coronary vasculature development
relationship: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis
creation_date: 2009-10-06T02:02:12Z

[Term]
id: GO:0060979
name: vasculogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart]
synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart]
synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001570 ! vasculogenesis
intersection_of: GO:0001570 ! vasculogenesis
intersection_of: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis
relationship: BFO:0000050 GO:0060977 ! part of coronary vasculature morphogenesis
creation_date: 2009-10-06T02:19:42Z

[Term]
id: GO:0060980
name: cell migration involved in coronary vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart]
is_a: GO:0035441 ! cell migration involved in vasculogenesis
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0060979 ! part of vasculogenesis involved in coronary vascular morphogenesis
relationship: BFO:0000050 GO:0060979 ! part of vasculogenesis involved in coronary vascular morphogenesis
creation_date: 2009-10-06T02:33:06Z

[Term]
id: GO:0060981
name: cell migration involved in coronary angiogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: BFO:0000050 GO:0060978 ! part of angiogenesis involved in coronary vascular morphogenesis
relationship: BFO:0000050 GO:0060978 ! part of angiogenesis involved in coronary vascular morphogenesis
creation_date: 2009-10-06T02:49:12Z

[Term]
id: GO:0060986
name: endocrine hormone secretion
namespace: biological_process
def: "The regulated release of a hormone into the circulatory system." [GOC:dph]
is_a: GO:0046879 ! hormone secretion
relationship: BFO:0000050 GO:0050886 ! part of endocrine process
creation_date: 2010-01-11T09:03:48Z

[Term]
id: GO:0061024
name: membrane organization
namespace: biological_process
alt_id: GO:0016044
alt_id: GO:0044802
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular membrane organisation" EXACT []
synonym: "cellular membrane organization" EXACT []
synonym: "membrane organisation" EXACT [GOC:mah]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
synonym: "single-organism membrane organization" RELATED []
xref: Reactome:R-HSA-199991 "Membrane Trafficking"
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0016020 ! results in organization of membrane
relationship: RO:0002592 GO:0016020 ! results in organization of membrane
created_by: jl
creation_date: 2010-02-08T02:43:11Z

[Term]
id: GO:0061025
name: membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "cellular membrane fusion" EXACT []
synonym: "single-organism membrane fusion" RELATED []
xref: Wikipedia:Lipid_bilayer_fusion
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0061024 ! membrane organization
intersection_of: RO:0012008 GO:0016020 ! results in fusion of membrane
relationship: RO:0012008 GO:0016020 ! results in fusion of membrane
creation_date: 2010-02-08T02:48:06Z

[Term]
id: GO:0061032
name: visceral serous pericardium development
namespace: biological_process
def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf]
synonym: "epicardium development" EXACT [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium
relationship: BFO:0000050 GO:0060039 ! part of pericardium development
relationship: RO:0002296 UBERON:0002425 ! results in development of visceral serous pericardium
creation_date: 2010-02-09T09:52:49Z

[Term]
id: GO:0061035
name: regulation of cartilage development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051216 ! regulates cartilage development
relationship: RO:0002211 GO:0051216 ! regulates cartilage development
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061036
name: positive regulation of cartilage development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051216 ! positively regulates cartilage development
relationship: RO:0002213 GO:0051216 ! positively regulates cartilage development
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061037
name: negative regulation of cartilage development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051216 ! negatively regulates cartilage development
relationship: RO:0002212 GO:0051216 ! negatively regulates cartilage development
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061040
name: female gonad morphogenesis
namespace: biological_process
def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph]
synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035262 ! gonad morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary
relationship: BFO:0000050 GO:0008585 ! part of female gonad development
relationship: RO:0002298 UBERON:0000992 ! results in morphogenesis of ovary
creation_date: 2010-02-22T11:29:28Z

[Term]
id: GO:0061046
name: regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis
relationship: RO:0002211 GO:0060441 ! regulates epithelial tube branching involved in lung morphogenesis
creation_date: 2010-02-25T10:41:38Z

[Term]
id: GO:0061047
name: positive regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis
relationship: RO:0002213 GO:0060441 ! positively regulates epithelial tube branching involved in lung morphogenesis
creation_date: 2010-02-25T10:50:01Z

[Term]
id: GO:0061048
name: negative regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis
relationship: RO:0002212 GO:0060441 ! negatively regulates epithelial tube branching involved in lung morphogenesis
creation_date: 2010-02-25T10:51:31Z

[Term]
id: GO:0061049
name: cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph]
synonym: "cardiomyocyte growth" RELATED [GOC:dph]
synonym: "heart muscle cell growth" RELATED [GOC:dph]
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0016049 ! cell growth
intersection_of: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development
relationship: BFO:0000050 GO:0003301 ! part of physiological cardiac muscle hypertrophy
relationship: BFO:0000050 GO:0055013 ! part of cardiac muscle cell development
creation_date: 2010-02-25T12:56:07Z

[Term]
id: GO:0061050
name: regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development
relationship: RO:0002211 GO:0061049 ! regulates cell growth involved in cardiac muscle cell development
creation_date: 2010-02-25T01:05:16Z

[Term]
id: GO:0061051
name: positive regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development
relationship: RO:0002213 GO:0061049 ! positively regulates cell growth involved in cardiac muscle cell development
creation_date: 2010-02-25T01:08:08Z

[Term]
id: GO:0061052
name: negative regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development
relationship: RO:0002212 GO:0061049 ! negatively regulates cell growth involved in cardiac muscle cell development
creation_date: 2010-02-25T01:11:30Z

[Term]
id: GO:0061053
name: somite development
namespace: biological_process
def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002329 ! results in development of somite
relationship: BFO:0000050 GO:0009790 ! part of embryo development
relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata
relationship: RO:0002296 UBERON:0002329 ! results in development of somite
creation_date: 2010-03-02T12:05:13Z

[Term]
id: GO:0061054
name: dermatome development
namespace: biological_process
def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004016 ! results in development of dermatome
relationship: BFO:0000050 GO:0061053 ! part of somite development
relationship: RO:0002296 UBERON:0004016 ! results in development of dermatome
creation_date: 2010-03-02T12:07:37Z

[Term]
id: GO:0061055
name: myotome development
namespace: biological_process
def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003082 ! results in development of myotome
relationship: BFO:0000050 GO:0061053 ! part of somite development
relationship: RO:0002296 UBERON:0003082 ! results in development of myotome
creation_date: 2010-03-02T12:11:01Z

[Term]
id: GO:0061056
name: sclerotome development
namespace: biological_process
def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003089 ! results in development of sclerotome
relationship: BFO:0000050 GO:0061053 ! part of somite development
relationship: RO:0002296 UBERON:0003089 ! results in development of sclerotome
creation_date: 2010-03-02T12:12:40Z

[Term]
id: GO:0061061
name: muscle structure development
namespace: biological_process
def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]
subset: goslim_drosophila
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005090 ! results in development of muscle structure
relationship: RO:0002296 UBERON:0005090 ! results in development of muscle structure
creation_date: 2010-03-09T08:55:14Z

[Term]
id: GO:0061072
name: iris morphogenesis
namespace: biological_process
def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris
relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis
relationship: RO:0002298 UBERON:0001769 ! results in morphogenesis of iris
creation_date: 2010-03-16T10:48:42Z

[Term]
id: GO:0061073
name: ciliary body morphogenesis
namespace: biological_process
def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body
relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis
relationship: RO:0002298 UBERON:0001775 ! results in morphogenesis of ciliary body
creation_date: 2010-03-16T10:55:19Z

[Term]
id: GO:0061074
name: regulation of neural retina development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003407 ! regulates neural retina development
relationship: RO:0002211 GO:0003407 ! regulates neural retina development
creation_date: 2010-03-16T11:47:05Z

[Term]
id: GO:0061075
name: positive regulation of neural retina development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902868 ! positive regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003407 ! positively regulates neural retina development
relationship: RO:0002213 GO:0003407 ! positively regulates neural retina development
creation_date: 2010-03-16T11:59:48Z

[Term]
id: GO:0061076
name: negative regulation of neural retina development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902867 ! negative regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003407 ! negatively regulates neural retina development
relationship: RO:0002212 GO:0003407 ! negatively regulates neural retina development
creation_date: 2010-03-16T12:46:11Z

[Term]
id: GO:0061080
name: right horn of sinus venosus development
namespace: biological_process
def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus
relationship: BFO:0000050 GO:0003235 ! part of sinus venosus development
relationship: RO:0002296 UBERON:0005092 ! results in development of right horn of sinus venosus
creation_date: 2010-04-08T02:45:10Z

[Term]
id: GO:0061081
name: positive regulation of myeloid leukocyte cytokine production involved in immune response
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph]
synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph]
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061082 ! positively regulates myeloid leukocyte cytokine production
relationship: RO:0002213 GO:0061082 ! positively regulates myeloid leukocyte cytokine production
creation_date: 2010-04-13T11:26:41Z

[Term]
id: GO:0061082
name: myeloid leukocyte cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response
creation_date: 2010-04-13T11:29:42Z

[Term]
id: GO:0061100
name: lung neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746]
is_a: GO:0061101 ! neuroendocrine cell differentiation
is_a: GO:0061140 ! lung secretory cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell
relationship: RO:0002315 CL:1000223 ! results in acquisition of features of pulmonary neuroendocrine cell
creation_date: 2010-04-27T03:28:46Z

[Term]
id: GO:0061101
name: neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0060563 ! neuroepithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell
relationship: RO:0002315 CL:0000165 ! results in acquisition of features of neuroendocrine cell
creation_date: 2010-04-28T09:42:20Z

[Term]
id: GO:0061109
name: dense core granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph]
synonym: "dense core granule organisation" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0031045 ! results in organization of dense core granule
relationship: RO:0002592 GO:0031045 ! results in organization of dense core granule
creation_date: 2010-05-01T09:34:37Z

[Term]
id: GO:0061111
name: epithelial-mesenchymal cell signaling involved in lung development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: BFO:0000050 GO:0030324 ! part of lung development
creation_date: 2010-05-05T11:14:38Z

[Term]
id: GO:0061117
name: negative regulation of heart growth
namespace: biological_process
def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd]
is_a: GO:0046621 ! negative regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060419 ! negatively regulates heart growth
relationship: RO:0002212 GO:0060419 ! negatively regulates heart growth
creation_date: 2010-05-17T07:31:28Z

[Term]
id: GO:0061138
name: morphogenesis of a branching epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0002009 ! morphogenesis of an epithelium
creation_date: 2010-05-25T09:05:34Z

[Term]
id: GO:0061140
name: lung secretory cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph]
is_a: GO:0060487 ! lung epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell
relationship: RO:0002315 CL:1000272 ! results in acquisition of features of lung secretory cell
creation_date: 2010-05-25T09:28:53Z

[Term]
id: GO:0061147
name: endocardial endothelium development
namespace: biological_process
def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
is_a: GO:0003158 ! endothelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium
relationship: BFO:0000050 GO:0003157 ! part of endocardium development
relationship: RO:0002296 UBERON:0005316 ! results in development of endocardial endothelium
creation_date: 2010-06-03T09:15:31Z

[Term]
id: GO:0061148
name: extracellular matrix organization involved in endocardium development
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0030198 ! extracellular matrix organization
intersection_of: BFO:0000050 GO:0003157 ! part of endocardium development
relationship: BFO:0000050 GO:0003157 ! part of endocardium development
creation_date: 2010-06-03T09:18:02Z

[Term]
id: GO:0061152
name: trachea submucosa development
namespace: biological_process
def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea
relationship: BFO:0000050 GO:0060438 ! part of trachea development
relationship: RO:0002296 UBERON:0002202 ! results in development of submucosa of trachea
creation_date: 2010-06-07T09:58:40Z

[Term]
id: GO:0061154
name: endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf]
is_a: GO:0003159 ! morphogenesis of an endothelium
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube
relationship: RO:0002298 UBERON:0003915 ! results in morphogenesis of endothelial tube
creation_date: 2010-06-15T09:05:00Z

[Term]
id: GO:0061155
name: pulmonary artery endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf]
is_a: GO:0061154 ! endothelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium
relationship: BFO:0000050 GO:0061156 ! part of pulmonary artery morphogenesis
relationship: RO:0002298 UBERON:0005317 ! results in morphogenesis of pulmonary artery endothelium
creation_date: 2010-06-15T09:09:04Z

[Term]
id: GO:0061156
name: pulmonary artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery
relationship: RO:0002298 UBERON:0002012 ! results in morphogenesis of pulmonary artery
creation_date: 2010-06-15T09:13:47Z

[Term]
id: GO:0061181
name: regulation of chondrocyte development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002063 ! regulates chondrocyte development
relationship: RO:0002211 GO:0002063 ! regulates chondrocyte development
creation_date: 2010-07-14T08:28:52Z

[Term]
id: GO:0061182
name: negative regulation of chondrocyte development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0032331 ! negative regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development
relationship: RO:0002212 GO:0002063 ! negatively regulates chondrocyte development
creation_date: 2010-07-14T08:33:05Z

[Term]
id: GO:0061183
name: regulation of dermatome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061054 ! regulates dermatome development
relationship: RO:0002211 GO:0061054 ! regulates dermatome development
creation_date: 2010-07-14T08:40:26Z

[Term]
id: GO:0061184
name: positive regulation of dermatome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061054 ! positively regulates dermatome development
relationship: RO:0002213 GO:0061054 ! positively regulates dermatome development
creation_date: 2010-07-14T08:42:03Z

[Term]
id: GO:0061185
name: negative regulation of dermatome development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061054 ! negatively regulates dermatome development
relationship: RO:0002212 GO:0061054 ! negatively regulates dermatome development
creation_date: 2010-07-14T08:43:08Z

[Term]
id: GO:0061189
name: positive regulation of sclerotome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0061190 ! regulation of sclerotome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061056 ! positively regulates sclerotome development
relationship: RO:0002213 GO:0061056 ! positively regulates sclerotome development
creation_date: 2010-07-14T09:17:23Z

[Term]
id: GO:0061190
name: regulation of sclerotome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061056 ! regulates sclerotome development
relationship: RO:0002211 GO:0061056 ! regulates sclerotome development
creation_date: 2010-07-14T09:19:47Z

[Term]
id: GO:0061193
name: taste bud development
namespace: biological_process
def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0007423 ! sensory organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001727 ! results in development of taste bud
relationship: BFO:0000050 GO:0043586 ! part of tongue development
relationship: RO:0002296 UBERON:0001727 ! results in development of taste bud
creation_date: 2010-07-27T10:55:08Z

[Term]
id: GO:0061194
name: taste bud morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0090596 ! sensory organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001727 ! results in morphogenesis of taste bud
relationship: BFO:0000050 GO:0043587 ! part of tongue morphogenesis
relationship: BFO:0000050 GO:0061193 ! part of taste bud development
relationship: RO:0002298 UBERON:0001727 ! results in morphogenesis of taste bud
creation_date: 2010-07-27T11:01:31Z

[Term]
id: GO:0061195
name: taste bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001727 ! results in formation of taste bud
relationship: BFO:0000050 GO:0061194 ! part of taste bud morphogenesis
relationship: RO:0002297 UBERON:0001727 ! results in formation of taste bud
creation_date: 2010-07-27T12:22:26Z

[Term]
id: GO:0061298
name: retina vasculature development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature development" EXACT [GOC:dph]
is_a: GO:0001944 ! vasculature development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina
relationship: BFO:0000050 GO:0060041 ! part of retina development in camera-type eye
relationship: RO:0002296 UBERON:0004864 ! results in development of vasculature of retina
creation_date: 2010-09-06T03:27:06Z

[Term]
id: GO:0061299
name: retina vasculature morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina
relationship: BFO:0000050 GO:0061298 ! part of retina vasculature development in camera-type eye
relationship: RO:0002298 UBERON:0004864 ! results in morphogenesis of vasculature of retina
creation_date: 2010-09-06T03:28:25Z

[Term]
id: GO:0061300
name: cerebellum vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0001944 ! vasculature development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0006694 ! results in development of cerebellum vasculature
relationship: RO:0002296 UBERON:0006694 ! results in development of cerebellum vasculature
creation_date: 2010-09-06T03:36:40Z

[Term]
id: GO:0061301
name: cerebellum vasculature morphogenesis
namespace: biological_process
def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0006694 ! results in morphogenesis of cerebellum vasculature
relationship: BFO:0000050 GO:0021549 ! part of cerebellum development
relationship: BFO:0000050 GO:0061300 ! part of cerebellum vasculature development
relationship: RO:0002298 UBERON:0006694 ! results in morphogenesis of cerebellum vasculature
creation_date: 2010-09-06T03:38:05Z

[Term]
id: GO:0061303
name: cornea development in camera-type eye
namespace: biological_process
def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000964 ! results in development of cornea
relationship: BFO:0000050 GO:0043010 ! part of camera-type eye development
relationship: RO:0002296 UBERON:0000964 ! results in development of cornea
creation_date: 2010-09-14T02:09:08Z

[Term]
id: GO:0061304
name: retinal blood vessel morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel
relationship: RO:0002298 UBERON:0003501 ! results in morphogenesis of retina blood vessel
creation_date: 2010-09-16T09:02:59Z

[Term]
id: GO:0061307
name: cardiac neural crest cell differentiation involved in heart development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442]
is_a: GO:0014033 ! neural crest cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0014033 ! neural crest cell differentiation
intersection_of: BFO:0000050 GO:0007507 ! part of heart development
creation_date: 2010-09-23T08:50:56Z

[Term]
id: GO:0061308
name: cardiac neural crest cell development involved in heart development
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0014032 ! neural crest cell development
intersection_of: GO:0014032 ! neural crest cell development
intersection_of: BFO:0000050 GO:0007507 ! part of heart development
relationship: BFO:0000050 GO:0061307 ! part of cardiac neural crest cell differentiation involved in heart development
creation_date: 2010-09-23T09:01:49Z

[Term]
id: GO:0061309
name: cardiac neural crest cell development involved in outflow tract morphogenesis
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development
intersection_of: GO:0014032 ! neural crest cell development
intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
creation_date: 2010-09-23T09:08:37Z

[Term]
id: GO:0061311
name: cell surface receptor signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling]
synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf]
synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: BFO:0000050 GO:0007507 ! part of heart development
relationship: BFO:0000050 GO:0007507 ! part of heart development
creation_date: 2010-09-23T09:18:32Z

[Term]
id: GO:0061323
name: cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
creation_date: 2010-09-28T09:05:26Z

[Term]
id: GO:0061325
name: cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis
creation_date: 2010-09-28T09:29:30Z

[Term]
id: GO:0061337
name: cardiac conduction
namespace: biological_process
def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph]
xref: Reactome:R-HSA-5576891 "Cardiac conduction"
is_a: GO:0008016 ! regulation of heart contraction
creation_date: 2010-09-29T08:46:05Z

[Term]
id: GO:0061343
name: cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0007155 ! cell adhesion
intersection_of: GO:0007155 ! cell adhesion
intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis
relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis
creation_date: 2010-09-29T11:34:06Z

[Term]
id: GO:0061344
name: regulation of cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061343 ! regulates cell adhesion involved in heart morphogenesis
relationship: RO:0002211 GO:0061343 ! regulates cell adhesion involved in heart morphogenesis
creation_date: 2010-09-29T11:35:27Z

[Term]
id: GO:0061351
name: neural precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]
is_a: GO:0008283 ! cell population proliferation
creation_date: 2010-10-01T11:06:04Z

[Term]
id: GO:0061385
name: fibroblast proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph]
is_a: GO:0048144 ! fibroblast proliferation
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0048144 ! fibroblast proliferation
intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis
creation_date: 2011-02-10T01:41:59Z

[Term]
id: GO:0061448
name: connective tissue development
namespace: biological_process
def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002384 ! results in development of connective tissue
relationship: RO:0002296 UBERON:0002384 ! results in development of connective tissue
creation_date: 2012-03-22T12:53:41Z

[Term]
id: GO:0061450
name: trophoblast cell migration
namespace: biological_process
def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000351 ! results in movement of trophoblast cell
relationship: BFO:0000050 GO:0007566 ! part of embryo implantation
relationship: RO:0002565 CL:0000351 ! results in movement of trophoblast cell
creation_date: 2012-07-10T08:38:37Z

[Term]
id: GO:0061458
name: reproductive system development
namespace: biological_process
def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000990 ! results in development of reproductive system
relationship: RO:0002296 UBERON:0000990 ! results in development of reproductive system
creation_date: 2012-08-22T17:47:53Z

[Term]
id: GO:0061462
name: protein localization to lysosome
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]
is_a: GO:0072665 ! protein localization to vacuole
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome
relationship: RO:0002339 GO:0005764 ! has target end location lysosome
creation_date: 2012-10-05T10:50:51Z

[Term]
id: GO:0061484
name: hematopoietic stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411]
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell
relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell
creation_date: 2012-12-04T09:41:02Z

[Term]
id: GO:0061512
name: protein localization to cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005929 ! has target end location cilium
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
relationship: RO:0002339 GO:0005929 ! has target end location cilium
creation_date: 2013-03-22T15:41:44Z

[Term]
id: GO:0061515
name: myeloid cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0030097 ! hemopoiesis
intersection_of: GO:0048468 ! cell development
intersection_of: RO:0002296 CL:0000763 ! results in development of myeloid cell
relationship: BFO:0000050 GO:0030099 ! part of myeloid cell differentiation
relationship: RO:0002296 CL:0000763 ! results in development of myeloid cell
creation_date: 2013-04-18T13:03:16Z

[Term]
id: GO:0061519
name: macrophage homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904]
is_a: GO:0001776 ! leukocyte homeostasis
is_a: GO:0002262 ! myeloid cell homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: RO:0012003 CL:0000235 ! acts on population of macrophage
relationship: RO:0012003 CL:0000235 ! acts on population of macrophage
creation_date: 2013-04-18T13:25:33Z

[Term]
id: GO:0061523
name: cilium disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "cilium resorption" EXACT [GOC:dph]
is_a: GO:0044782 ! cilium organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005929 ! results in disassembly of cilium
relationship: RO:0002590 GO:0005929 ! results in disassembly of cilium
creation_date: 2013-04-18T14:59:59Z

[Term]
id: GO:0061524
name: central canal development
namespace: biological_process
def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002291 ! results in development of central canal of spinal cord
relationship: BFO:0000050 GO:0021510 ! part of spinal cord development
relationship: RO:0002296 UBERON:0002291 ! results in development of central canal of spinal cord
creation_date: 2013-04-20T08:18:31Z

[Term]
id: GO:0061526
name: acetylcholine secretion
namespace: biological_process
def: "The regulated release of acetylcholine by a cell." [GOC:dph]
is_a: GO:0015870 ! acetylcholine transport
is_a: GO:0023061 ! signal release
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
creation_date: 2013-06-21T15:40:39Z

[Term]
id: GO:0061527
name: dopamine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0099124 ! axonal dopamine secretion
is_a: GO:0160043 ! catecholamine secretion, neurotransmission
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
relationship: BFO:0000050 GO:0001963 ! part of synaptic transmission, dopaminergic
creation_date: 2013-06-21T15:43:15Z

[Term]
id: GO:0061533
name: norepinephrine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph]
synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0048243 ! norepinephrine secretion
is_a: GO:0160043 ! catecholamine secretion, neurotransmission
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:72587 ! has primary input
creation_date: 2013-06-21T16:05:08Z

[Term]
id: GO:0061534
name: gamma-aminobutyric acid secretion, neurotransmission
namespace: biological_process
def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014051 ! gamma-aminobutyric acid secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:59888 ! has primary input
relationship: BFO:0000050 GO:0051932 ! part of synaptic transmission, GABAergic
creation_date: 2013-06-21T16:10:50Z

[Term]
id: GO:0061535
name: glutamate secretion, neurotransmission
namespace: biological_process
def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0014047 ! glutamate secretion
is_a: GO:0051938 ! L-glutamate import
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
relationship: BFO:0000050 GO:0035249 ! part of synaptic transmission, glutamatergic
creation_date: 2013-06-21T16:14:47Z

[Term]
id: GO:0061536
name: glycine secretion
namespace: biological_process
def: "The controlled release of glycine by a cell." [GOC:dph]
is_a: GO:0015816 ! glycine transport
is_a: GO:0032940 ! secretion by cell
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
creation_date: 2013-06-21T16:18:23Z

[Term]
id: GO:0061537
name: glycine secretion, neurotransmission
namespace: biological_process
def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061536 ! glycine secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
relationship: BFO:0000050 GO:0060012 ! part of synaptic transmission, glycinergic
creation_date: 2013-06-21T16:19:02Z

[Term]
id: GO:0061548
name: ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "ganglia development" RELATED [GOC:dph]
synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000045 ! results in development of ganglion
relationship: BFO:0000050 GO:0007399 ! part of nervous system development
relationship: RO:0002296 UBERON:0000045 ! results in development of ganglion
creation_date: 2013-07-10T08:36:12Z

[Term]
id: GO:0061549
name: sympathetic ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl]
synonym: "sympathetic ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion
relationship: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development
relationship: RO:0002296 UBERON:0001806 ! results in development of sympathetic ganglion
creation_date: 2013-07-10T08:38:01Z

[Term]
id: GO:0061550
name: cranial ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "cranial ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion
relationship: BFO:0000050 GO:0021545 ! part of cranial nerve development
relationship: RO:0002296 UBERON:0001714 ! results in development of cranial ganglion
creation_date: 2013-07-10T08:40:14Z

[Term]
id: GO:0061551
name: trigeminal ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "trigeminal ganglia development" RELATED [GOC:dph]
is_a: GO:0061550 ! cranial ganglion development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion
relationship: RO:0002296 UBERON:0001675 ! results in development of trigeminal ganglion
creation_date: 2013-07-10T08:42:19Z

[Term]
id: GO:0061552
name: ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph]
synonym: "ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion
relationship: BFO:0000050 GO:0061548 ! part of ganglion development
relationship: RO:0002298 UBERON:0000045 ! results in morphogenesis of ganglion
creation_date: 2013-07-10T08:44:57Z

[Term]
id: GO:0061553
name: ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph]
synonym: "ganglia maturation" RELATED [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: RO:0002299 UBERON:0000045 ! results in maturation of ganglion
relationship: BFO:0000050 GO:0061548 ! part of ganglion development
relationship: RO:0002299 UBERON:0000045 ! results in maturation of ganglion
creation_date: 2013-07-10T08:45:59Z

[Term]
id: GO:0061554
name: ganglion formation
namespace: biological_process
def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "ganglia formation" RELATED [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000045 ! results in formation of ganglion
relationship: BFO:0000050 GO:0061552 ! part of ganglion morphogenesis
relationship: RO:0002297 UBERON:0000045 ! results in formation of ganglion
creation_date: 2013-07-10T08:51:50Z

[Term]
id: GO:0061556
name: trigeminal ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph]
synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061559 ! cranial ganglion morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion
relationship: BFO:0000050 GO:0021636 ! part of trigeminal nerve morphogenesis
relationship: BFO:0000050 GO:0061551 ! part of trigeminal ganglion development
relationship: RO:0002298 UBERON:0001675 ! results in morphogenesis of trigeminal ganglion
creation_date: 2013-07-10T08:57:12Z

[Term]
id: GO:0061557
name: trigeminal ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph]
synonym: "trigeminal ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061558 ! cranial ganglion maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion
relationship: BFO:0000050 GO:0021635 ! part of trigeminal nerve maturation
relationship: BFO:0000050 GO:0061551 ! part of trigeminal ganglion development
relationship: RO:0002299 UBERON:0001675 ! results in maturation of trigeminal ganglion
creation_date: 2013-07-10T08:58:24Z

[Term]
id: GO:0061558
name: cranial ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph]
synonym: "cranial ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061553 ! ganglion maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion
relationship: BFO:0000050 GO:0021605 ! part of cranial nerve maturation
relationship: BFO:0000050 GO:0061550 ! part of cranial ganglion development
relationship: RO:0002299 UBERON:0001714 ! results in maturation of cranial ganglion
creation_date: 2013-07-10T08:59:52Z

[Term]
id: GO:0061559
name: cranial ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph]
synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061552 ! ganglion morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion
relationship: BFO:0000050 GO:0021602 ! part of cranial nerve morphogenesis
relationship: BFO:0000050 GO:0061550 ! part of cranial ganglion development
relationship: RO:0002298 UBERON:0001714 ! results in morphogenesis of cranial ganglion
creation_date: 2013-07-10T09:02:15Z

[Term]
id: GO:0061560
name: cranial ganglion formation
namespace: biological_process
def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "cranial ganglia formation" RELATED [GOC:dph]
is_a: GO:0061554 ! ganglion formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001714 ! results in formation of cranial ganglion
relationship: BFO:0000050 GO:0061559 ! part of cranial ganglion morphogenesis
relationship: RO:0002297 UBERON:0001714 ! results in formation of cranial ganglion
creation_date: 2013-07-10T09:07:27Z

[Term]
id: GO:0061561
name: trigeminal ganglion formation
namespace: biological_process
def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "trigeminal ganglia formation" RELATED [GOC:dph]
is_a: GO:0061560 ! cranial ganglion formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0001675 ! results in formation of trigeminal ganglion
relationship: BFO:0000050 GO:0061556 ! part of trigeminal ganglion morphogenesis
relationship: RO:0002297 UBERON:0001675 ! results in formation of trigeminal ganglion
creation_date: 2013-07-10T09:08:13Z

[Term]
id: GO:0061564
name: axon development
namespace: biological_process
def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]
is_a: GO:0031175 ! neuron projection development
creation_date: 2013-07-18T14:43:01Z

[Term]
id: GO:0061572
name: actin filament bundle organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph]
synonym: "actin filament cable organization" RELATED [GOC:dph]
is_a: GO:0007015 ! actin filament organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0032432 ! results in organization of actin filament bundle
relationship: RO:0002592 GO:0032432 ! results in organization of actin filament bundle
creation_date: 2013-08-02T11:24:11Z

[Term]
id: GO:0061581
name: corneal epithelial cell migration
namespace: biological_process
def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000575 ! results in movement of corneal epithelial cell
relationship: RO:0002565 CL:0000575 ! results in movement of corneal epithelial cell
creation_date: 2013-12-23T07:28:29Z

[Term]
id: GO:0061626
name: pharyngeal arch artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914]
synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery
relationship: BFO:0000050 GO:0060037 ! part of pharyngeal system development
relationship: RO:0002298 UBERON:0004363 ! results in morphogenesis of pharyngeal arch artery
creation_date: 2014-05-09T15:34:06Z

[Term]
id: GO:0061629
name: RNA polymerase II-specific DNA-binding transcription factor binding
namespace: molecular_function
def: "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]
synonym: "RNA polymerase II activating transcription factor binding" RELATED []
synonym: "RNA polymerase II repressing transcription factor binding" RELATED []
synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT []
synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT []
synonym: "RNA polymerase II transcription factor binding" RELATED []
is_a: GO:0140297 ! DNA-binding transcription factor binding
creation_date: 2014-05-15T09:12:24Z

[Term]
id: GO:0061650
name: ubiquitin-like protein conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD []
synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
created_by: dph
creation_date: 2014-11-06T13:15:27Z

[Term]
id: GO:0061651
name: Atg12 conjugating enzyme activity
namespace: molecular_function
def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph]
synonym: "E2" BROAD [GOC:dph]
is_a: GO:0019777 ! Atg12 transferase activity
is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity
created_by: dph
creation_date: 2014-11-06T13:17:36Z

[Term]
id: GO:0061659
name: ubiquitin-like protein ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" RELATED [GOC:dph]
synonym: "small conjugating protein ligase activity" EXACT [GOC:dph]
is_a: GO:0019787 ! ubiquitin-like protein transferase activity
created_by: dph
creation_date: 2014-11-06T13:46:23Z

[Term]
id: GO:0061660
name: Atg12 ligase activity
namespace: molecular_function
def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]
synonym: "E3" BROAD [GOC:dph]
is_a: GO:0019777 ! Atg12 transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
created_by: dph
creation_date: 2014-11-06T13:50:42Z

[Term]
id: GO:0061668
name: mitochondrial ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph]
is_a: GO:0042255 ! ribosome assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005761 ! results in assembly of mitochondrial ribosome
relationship: RO:0002588 GO:0005761 ! results in assembly of mitochondrial ribosome
creation_date: 2014-11-07T15:32:20Z

[Term]
id: GO:0061725
name: cytosolic lipolysis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy]
is_a: GO:0016042 ! lipid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: BFO:0000066 GO:0005829 ! occurs in cytosol
creation_date: 2015-07-08T13:42:15Z

[Term]
id: GO:0061736
name: engulfment of target by autophagosome
namespace: biological_process
def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL]
is_a: GO:0010324 ! membrane invagination
intersection_of: GO:0010324 ! membrane invagination
intersection_of: BFO:0000050 GO:0000045 ! part of autophagosome assembly
relationship: BFO:0000050 GO:0000045 ! part of autophagosome assembly
created_by: dph
creation_date: 2015-09-14T14:10:24Z

[Term]
id: GO:0061792
name: secretory granule maturation
namespace: biological_process
def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809]
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 GO:0030141 ! results in maturation of secretory granule
relationship: RO:0002299 GO:0030141 ! results in maturation of secretory granule
creation_date: 2016-09-09T13:24:34Z

[Term]
id: GO:0061853
name: regulation of neuroblast migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097402 ! regulates neuroblast migration
relationship: RO:0002211 GO:0097402 ! regulates neuroblast migration
creation_date: 2017-03-08T18:17:07Z

[Term]
id: GO:0061854
name: positive regulation of neuroblast migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0061853 ! regulation of neuroblast migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097402 ! positively regulates neuroblast migration
relationship: RO:0002213 GO:0097402 ! positively regulates neuroblast migration
creation_date: 2017-03-08T18:22:30Z

[Term]
id: GO:0061855
name: negative regulation of neuroblast migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0061853 ! regulation of neuroblast migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097402 ! negatively regulates neuroblast migration
relationship: RO:0002212 GO:0097402 ! negatively regulates neuroblast migration
creation_date: 2017-03-08T18:26:21Z

[Term]
id: GO:0061880
name: regulation of anterograde axonal transport of mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729]
synonym: "regulation of anterograde axon transport of mitochondria" EXACT []
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098957 ! regulates anterograde axonal transport of mitochondrion
relationship: RO:0002211 GO:0098957 ! regulates anterograde axonal transport of mitochondrion
creation_date: 2017-05-30T14:15:46Z

[Term]
id: GO:0061881
name: positive regulation of anterograde axonal transport of mitochondrion
namespace: biological_process
def: "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729]
synonym: "positive regulation of anterograde axon transport of mitochondria" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098957 ! positively regulates anterograde axonal transport of mitochondrion
relationship: RO:0002213 GO:0098957 ! positively regulates anterograde axonal transport of mitochondrion
creation_date: 2017-05-30T14:21:08Z

[Term]
id: GO:0061882
name: negative regulation of anterograde axonal transport of mitochondrion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729]
synonym: "negative regulation of anterograde axon transport of mitochondria" EXACT []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098957 ! negatively regulates anterograde axonal transport of mitochondrion
relationship: RO:0002212 GO:0098957 ! negatively regulates anterograde axonal transport of mitochondrion
creation_date: 2017-05-30T14:25:16Z

[Term]
id: GO:0061888
name: regulation of astrocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821]
is_a: GO:0048710 ! regulation of astrocyte differentiation
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048143 ! regulates astrocyte activation
relationship: RO:0002211 GO:0048143 ! regulates astrocyte activation
creation_date: 2017-06-01T22:26:29Z

[Term]
id: GO:0061889
name: negative regulation of astrocyte activation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821]
is_a: GO:0048712 ! negative regulation of astrocyte differentiation
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:0061888 ! regulation of astrocyte activation
is_a: GO:0150079 ! negative regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048143 ! negatively regulates astrocyte activation
relationship: RO:0002212 GO:0048143 ! negatively regulates astrocyte activation
creation_date: 2017-06-01T22:29:43Z

[Term]
id: GO:0061890
name: positive regulation of astrocyte activation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821]
is_a: GO:0048711 ! positive regulation of astrocyte differentiation
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:0061888 ! regulation of astrocyte activation
is_a: GO:0150078 ! positive regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048143 ! positively regulates astrocyte activation
relationship: RO:0002213 GO:0048143 ! positively regulates astrocyte activation
creation_date: 2017-06-01T22:31:50Z

[Term]
id: GO:0061900
name: glial cell activation
namespace: biological_process
def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000125 ! has primary input glial cell
relationship: BFO:0000050 GO:0150076 ! part of neuroinflammatory response
relationship: RO:0004009 CL:0000125 ! has primary input glial cell
creation_date: 2017-06-13T13:06:23Z

[Term]
id: GO:0061919
name: process utilizing autophagic mechanism
namespace: biological_process
def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
created_by: dph
creation_date: 2017-07-13T19:42:14Z

[Term]
id: GO:0061938
name: protein localization to somatodendritic compartment
namespace: biological_process
def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993]
synonym: "somatodendritic protein localization" EXACT []
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment
relationship: RO:0002339 GO:0036477 ! has target end location somatodendritic compartment
creation_date: 2017-09-08T13:22:26Z

[Term]
id: GO:0061951
name: establishment of protein localization to plasma membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw]
is_a: GO:0072659 ! protein localization to plasma membrane
is_a: GO:0090150 ! establishment of protein localization to membrane
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure
intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
created_by: dph
creation_date: 2017-10-26T12:55:15Z

[Term]
id: GO:0061971
name: replacement bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [PMID:29852585]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone
relationship: RO:0002298 UBERON:0012075 ! results in morphogenesis of replacement bone
creation_date: 2018-02-12T18:10:59Z

[Term]
id: GO:0061972
name: dermal bone morphogenesis
namespace: biological_process
def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632]
is_a: GO:0061973 ! membrane bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone
relationship: RO:0002298 UBERON:0008907 ! results in morphogenesis of dermal bone
creation_date: 2018-02-12T18:16:21Z

[Term]
id: GO:0061973
name: membrane bone morphogenesis
namespace: biological_process
def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone
relationship: RO:0002298 UBERON:0007842 ! results in morphogenesis of membrane bone
creation_date: 2018-02-12T18:21:09Z

[Term]
id: GO:0061982
name: meiosis I cell cycle process
namespace: biological_process
def: "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397]
synonym: "first meiotic cell division" EXACT [PMID:29385397]
is_a: GO:1903046 ! meiotic cell cycle process
created_by: dph
creation_date: 2018-02-14T22:27:20Z

[Term]
id: GO:0061983
name: meiosis II cell cycle process
namespace: biological_process
def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397]
synonym: "second meiotic division" EXACT [PMID:29385397]
is_a: GO:1903046 ! meiotic cell cycle process
created_by: dph
creation_date: 2018-02-14T22:37:44Z

[Term]
id: GO:0062012
name: regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]
synonym: "regulation of small molecule metabolism" EXACT []
xref: Reactome:R-HSA-9861718 "Regulation of pyruvate metabolism"
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044281 ! regulates small molecule metabolic process
relationship: RO:0002211 GO:0044281 ! regulates small molecule metabolic process
created_by: dph
creation_date: 2018-03-19T14:11:54Z

[Term]
id: GO:0062013
name: positive regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]
synonym: "positive regulation of small molecule metabolism" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process
relationship: RO:0002213 GO:0044281 ! positively regulates small molecule metabolic process
creation_date: 2018-03-19T14:25:10Z

[Term]
id: GO:0062014
name: negative regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]
synonym: "negative regulation of small molecule metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process
relationship: RO:0002212 GO:0044281 ! negatively regulates small molecule metabolic process
creation_date: 2018-03-19T14:27:23Z

[Term]
id: GO:0062033
name: positive regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation
relationship: RO:0002213 GO:0000070 ! positively regulates mitotic sister chromatid segregation
creation_date: 2018-04-23T14:32:23Z

[Term]
id: GO:0062125
name: regulation of mitochondrial gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [PMID:28285835]
is_a: GO:0010468 ! regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression
relationship: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression
creation_date: 2019-05-30T16:45:04Z

[Term]
id: GO:0062149
name: detection of stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031]
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: BFO:0000050 GO:0019233 ! part of sensory perception of pain
relationship: BFO:0000050 GO:0019233 ! part of sensory perception of pain
creation_date: 2019-09-13T13:48:47Z

[Term]
id: GO:0062197
name: cellular response to chemical stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712]
xref: Reactome:R-HSA-9711123 "Cellular response to chemical stress"
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0070887 ! cellular response to chemical stimulus
creation_date: 2019-12-10T14:42:03Z

[Term]
id: GO:0062237
name: protein localization to postsynapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538]
is_a: GO:0035418 ! protein localization to synapse
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse
relationship: RO:0002339 GO:0098794 ! has target end location postsynapse
creation_date: 2020-04-20T13:58:43Z

[Term]
id: GO:0062247
name: chloroplast vesicle
namespace: cellular_component
def: "A intracellular vesicle that is part of a chloroplast." [PMID:32245810]
is_a: GO:0031410 ! cytoplasmic vesicle
intersection_of: GO:0097708 ! intracellular vesicle
intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
relationship: BFO:0000050 GO:0009507 ! part of chloroplast
creation_date: 2020-05-01T12:10:16Z

[Term]
id: GO:0065002
name: intracellular protein transmembrane transport
namespace: biological_process
def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "intracellular membrane translocation of a protein" EXACT []
synonym: "intracellular protein membrane transport" EXACT []
synonym: "intracellular protein transport across a membrane" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0071806 ! protein transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: BFO:0000066 GO:0005622 ! occurs in intracellular anatomical structure
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0065003
name: protein-containing complex assembly
namespace: biological_process
alt_id: GO:0006461
alt_id: GO:0034622
alt_id: GO:0043623
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular macromolecule complex assembly" RELATED []
synonym: "cellular protein complex assembly" EXACT []
synonym: "cellular protein-containing complex assembly" RELATED []
synonym: "chaperone activity" RELATED []
synonym: "macromolecular complex assembly" RELATED []
synonym: "macromolecule complex assembly" RELATED []
synonym: "protein complex assembly" RELATED []
synonym: "protein complex formation" RELATED []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex
relationship: RO:0002588 GO:0032991 ! results in assembly of protein-containing complex

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "regulation" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0065008
name: regulation of biological quality
namespace: biological_process
def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "regulation of biological attribute" EXACT []
synonym: "regulation of biological characteristic" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065009
name: regulation of molecular function
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]
subset: gocheck_obsoletion_candidate
subset: goslim_pir
subset: goslim_plant
synonym: "regulation of a molecular function" EXACT []
is_a: GO:0065007 ! biological regulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003674 ! regulates molecular_function
relationship: RO:0002211 GO:0003674 ! regulates molecular_function

[Term]
id: GO:0065010
name: extracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]
synonym: "extracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle
intersection_of: GO:0043227 ! membrane-bounded organelle
intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region

[Term]
id: GO:0070013
name: intracellular organelle lumen
namespace: cellular_component
def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: BFO:0000050 GO:0043229 ! part of intracellular organelle
relationship: BFO:0000050 GO:0043229 ! part of intracellular organelle

[Term]
id: GO:0070050
name: neuron cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
synonym: "neuron maintenance" EXACT []
is_a: GO:0019725 ! cellular homeostasis
intersection_of: GO:0019725 ! cellular homeostasis
intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron
relationship: BFO:0000066 CL:0000540 ! occurs in neuron

[Term]
id: GO:0070051
name: fibrinogen binding
namespace: molecular_function
def: "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk]
is_a: GO:0044877 ! protein-containing complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0005577 ! has primary input fibrinogen complex
relationship: RO:0004009 GO:0005577 ! has primary input fibrinogen complex

[Term]
id: GO:0070062
name: extracellular exosome
namespace: cellular_component
def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
synonym: "exosome" EXACT [GOC:pr]
synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles]
is_a: GO:1903561 ! extracellular vesicle
relationship: BFO:0000050 GO:0005615 ! part of extracellular space

[Term]
id: GO:0070124
name: mitochondrial translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah]
synonym: "mitochondrial translation initiation" EXACT [GOC:mah]
xref: Reactome:R-HSA-5368286 "Mitochondrial translation initiation"
is_a: GO:0006413 ! translational initiation
intersection_of: GO:0006413 ! translational initiation
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation

[Term]
id: GO:0070125
name: mitochondrial translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]
synonym: "mitochondrial translation elongation" EXACT [GOC:mah]
xref: Reactome:R-HSA-5389840 "Mitochondrial translation elongation"
is_a: GO:0006414 ! translational elongation
intersection_of: GO:0006414 ! translational elongation
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation

[Term]
id: GO:0070126
name: mitochondrial translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria]
synonym: "mitochondrial translation termination" EXACT [GOC:mah]
xref: Reactome:R-HSA-5419276 "Mitochondrial translation termination"
is_a: GO:0006415 ! translational termination
intersection_of: GO:0006415 ! translational termination
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0032543 ! part of mitochondrial translation

[Term]
id: GO:0070129
name: regulation of mitochondrial translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0062125 ! regulation of mitochondrial gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032543 ! regulates mitochondrial translation
relationship: RO:0002211 GO:0032543 ! regulates mitochondrial translation

[Term]
id: GO:0070130
name: negative regulation of mitochondrial translation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032543 ! negatively regulates mitochondrial translation
relationship: RO:0002212 GO:0032543 ! negatively regulates mitochondrial translation

[Term]
id: GO:0070131
name: positive regulation of mitochondrial translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation
relationship: RO:0002213 GO:0032543 ! positively regulates mitochondrial translation

[Term]
id: GO:0070132
name: regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0070129 ! regulation of mitochondrial translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070124 ! regulates mitochondrial translational initiation
relationship: RO:0002211 GO:0070124 ! regulates mitochondrial translational initiation

[Term]
id: GO:0070133
name: negative regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070124 ! negatively regulates mitochondrial translational initiation
relationship: RO:0002212 GO:0070124 ! negatively regulates mitochondrial translational initiation

[Term]
id: GO:0070134
name: positive regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:0070131 ! positive regulation of mitochondrial translation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070124 ! positively regulates mitochondrial translational initiation
relationship: RO:0002213 GO:0070124 ! positively regulates mitochondrial translational initiation

[Term]
id: GO:0070160
name: tight junction
namespace: cellular_component
def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181]
synonym: "occluding cell junction" EXACT [GOC:mah]
synonym: "occluding junction" EXACT [GOC:mah]
xref: Wikipedia:Tight_junction
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0070161
name: anchoring junction
namespace: cellular_component
def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]
synonym: "anchoring cell junction" EXACT [GOC:mah]
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0070192
name: chromosome organization involved in meiotic cell cycle
namespace: biological_process
def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]
synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah]
synonym: "meiotic chromosome organization" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051276 ! chromosome organization
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle

[Term]
id: GO:0070199
name: establishment of protein localization to chromosome
namespace: biological_process
def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
is_a: GO:0072594 ! establishment of protein localization to organelle
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0005694 ! has target end location chromosome

[Term]
id: GO:0070201
name: regulation of establishment of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045184 ! regulates establishment of protein localization
relationship: RO:0002211 GO:0045184 ! regulates establishment of protein localization

[Term]
id: GO:0070202
name: regulation of establishment of protein localization to chromosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome
relationship: RO:0002211 GO:0070199 ! regulates establishment of protein localization to chromosome

[Term]
id: GO:0070227
name: lymphocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "lymphocyte apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte
relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte

[Term]
id: GO:0070228
name: regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "regulation of lymphocyte apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070227 ! regulates lymphocyte apoptotic process
relationship: RO:0002211 GO:0070227 ! regulates lymphocyte apoptotic process

[Term]
id: GO:0070229
name: negative regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of lymphocyte apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070227 ! negatively regulates lymphocyte apoptotic process
relationship: RO:0002212 GO:0070227 ! negatively regulates lymphocyte apoptotic process

[Term]
id: GO:0070230
name: positive regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of lymphocyte apoptosis" NARROW []
synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070227 ! positively regulates lymphocyte apoptotic process
relationship: RO:0002213 GO:0070227 ! positively regulates lymphocyte apoptotic process

[Term]
id: GO:0070231
name: T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "T cell apoptosis" NARROW []
synonym: "T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "T-cell apoptosis" EXACT [GOC:add]
synonym: "T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell
relationship: BFO:0000066 CL:0000084 ! occurs in T cell

[Term]
id: GO:0070232
name: regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "regulation of T cell apoptosis" NARROW []
synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070231 ! regulates T cell apoptotic process
relationship: RO:0002211 GO:0070231 ! regulates T cell apoptotic process

[Term]
id: GO:0070233
name: negative regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of T cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of T cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T cell apoptosis" NARROW []
synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070231 ! negatively regulates T cell apoptotic process
relationship: RO:0002212 GO:0070231 ! negatively regulates T cell apoptotic process

[Term]
id: GO:0070234
name: positive regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of T cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T cell apoptosis" NARROW []
synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
synonym: "stimulation of T cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of T cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070231 ! positively regulates T cell apoptotic process
relationship: RO:0002213 GO:0070231 ! positively regulates T cell apoptotic process

[Term]
id: GO:0070265
name: obsolete necrotic cell death
namespace: biological_process
def: "OBSOLETE. A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]
comment: The reason for obsoletion is that this term represent an assay and not a GO process.\n The reason for obsoletion is that this represents a phenotype.
synonym: "cellular necrosis" EXACT [GOC:add]
synonym: "necrosis" BROAD [GOC:mah]

[Term]
id: GO:0070278
name: extracellular matrix constituent secretion
namespace: biological_process
def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah]
synonym: "ECM constituent secretion" EXACT [GOC:mah]
synonym: "ECM secretion" EXACT [GOC:mah]
is_a: GO:0032940 ! secretion by cell
relationship: BFO:0000050 GO:0030198 ! part of extracellular matrix organization

[Term]
id: GO:0070285
name: pigment cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0000147 ! results in development of pigment cell
relationship: BFO:0000050 GO:0050931 ! part of pigment cell differentiation
relationship: RO:0002296 CL:0000147 ! results in development of pigment cell

[Term]
id: GO:0070341
name: fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl]
synonym: "adipocyte proliferation" EXACT [GOC:sl]
synonym: "adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000136 ! acts on population of adipocyte
relationship: RO:0012003 CL:0000136 ! acts on population of adipocyte

[Term]
id: GO:0070344
name: regulation of fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070341 ! regulates fat cell proliferation
relationship: RO:0002211 GO:0070341 ! regulates fat cell proliferation

[Term]
id: GO:0070345
name: negative regulation of fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation
relationship: RO:0002212 GO:0070341 ! negatively regulates fat cell proliferation

[Term]
id: GO:0070346
name: positive regulation of fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation
relationship: RO:0002213 GO:0070341 ! positively regulates fat cell proliferation

[Term]
id: GO:0070382
name: exocytic vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT []
synonym: "exocytotic vesicle" EXACT [GOC:kad]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0099503 ! secretory vesicle
intersection_of: GO:0030133 ! transport vesicle
intersection_of: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane

[Term]
id: GO:0070444
name: oligodendrocyte progenitor proliferation
namespace: biological_process
def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915]
synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0002453 ! acts on population of oligodendrocyte precursor cell
relationship: BFO:0000050 GO:0042063 ! part of gliogenesis
relationship: RO:0012003 CL:0002453 ! acts on population of oligodendrocyte precursor cell

[Term]
id: GO:0070445
name: regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070444 ! regulates oligodendrocyte progenitor proliferation
relationship: RO:0002211 GO:0070444 ! regulates oligodendrocyte progenitor proliferation

[Term]
id: GO:0070446
name: negative regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070444 ! negatively regulates oligodendrocyte progenitor proliferation
relationship: RO:0002212 GO:0070444 ! negatively regulates oligodendrocyte progenitor proliferation

[Term]
id: GO:0070447
name: positive regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070444 ! positively regulates oligodendrocyte progenitor proliferation
relationship: RO:0002213 GO:0070444 ! positively regulates oligodendrocyte progenitor proliferation

[Term]
id: GO:0070459
name: prolactin secretion
namespace: biological_process
def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732]
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: RO:0004009 PR:000013246 ! has primary input prolactin
relationship: RO:0004009 PR:000013246 ! has primary input prolactin

[Term]
id: GO:0070482
name: response to oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0070483
name: detection of hypoxia
namespace: biological_process
def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah]
synonym: "detection of reduced oxygen levels" EXACT [GOC:vk]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0003032 ! detection of oxygen

[Term]
id: GO:0070507
name: regulation of microtubule cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization
relationship: RO:0002211 GO:0000226 ! regulates microtubule cytoskeleton organization

[Term]
id: GO:0070585
name: protein localization to mitochondrion
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]
synonym: "protein localisation in mitochondrion" EXACT [GOC:mah]
synonym: "protein localization in mitochondrion" EXACT []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005739 ! has target end location mitochondrion
relationship: RO:0002339 GO:0005739 ! has target end location mitochondrion
creation_date: 2009-04-24T02:31:18Z

[Term]
id: GO:0070586
name: cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation
relationship: BFO:0000050 GO:0007369 ! part of gastrulation
creation_date: 2009-04-24T02:48:23Z

[Term]
id: GO:0070587
name: regulation of cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070586 ! regulates cell-cell adhesion involved in gastrulation
relationship: RO:0002211 GO:0070586 ! regulates cell-cell adhesion involved in gastrulation
creation_date: 2009-04-24T02:51:07Z

[Term]
id: GO:0070633
name: transepithelial transport
namespace: biological_process
def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithelium
relationship: RO:0002342 UBERON:0000483 ! results in transport across epithelium
creation_date: 2009-05-06T03:31:02Z

[Term]
id: GO:0070661
name: leukocyte proliferation
namespace: biological_process
def: "The expansion of a leukocyte population by cell division." [GOC:add]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000738 ! acts on population of leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte
creation_date: 2009-05-28T05:25:28Z

[Term]
id: GO:0070663
name: regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070661 ! regulates leukocyte proliferation
relationship: RO:0002211 GO:0070661 ! regulates leukocyte proliferation
creation_date: 2009-05-28T05:30:39Z

[Term]
id: GO:0070664
name: negative regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation
relationship: RO:0002212 GO:0070661 ! negatively regulates leukocyte proliferation
creation_date: 2009-05-28T05:34:50Z

[Term]
id: GO:0070665
name: positive regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "activation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation
relationship: RO:0002213 GO:0070661 ! positively regulates leukocyte proliferation
creation_date: 2009-05-28T05:36:46Z

[Term]
id: GO:0070727
name: cellular macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
synonym: "cellular macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
is_a: GO:0051641 ! cellular localization
created_by: mah
creation_date: 2009-06-16T04:08:29Z

[Term]
id: GO:0070828
name: heterochromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah]
synonym: "heterochromatin organisation" EXACT [GOC:mah]
is_a: GO:0006325 ! chromatin organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0000792 ! results in organization of heterochromatin
relationship: RO:0002592 GO:0000792 ! results in organization of heterochromatin
creation_date: 2009-07-23T04:12:48Z

[Term]
id: GO:0070830
name: bicellular tight junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah]
synonym: "tight junction formation" EXACT [GOC:mah]
xref: Reactome:R-HSA-420029 "Tight junction interactions"
is_a: GO:0120192 ! tight junction assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005923 ! results in assembly of bicellular tight junction
relationship: BFO:0000050 GO:0043297 ! part of apical junction assembly
relationship: RO:0002588 GO:0005923 ! results in assembly of bicellular tight junction
creation_date: 2009-07-23T04:32:38Z

[Term]
id: GO:0070831
name: basement membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.
is_a: GO:0071711 ! basement membrane organization
is_a: GO:0085029 ! extracellular matrix assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005604 ! results in assembly of basement membrane
relationship: RO:0002588 GO:0005604 ! results in assembly of basement membrane
creation_date: 2009-07-23T05:01:51Z

[Term]
id: GO:0070851
name: growth factor receptor binding
namespace: molecular_function
def: "Binding to a growth factor receptor." [GOC:mah, GOC:vw]
is_a: GO:0005102 ! signaling receptor binding
creation_date: 2009-08-07T11:23:02Z

[Term]
id: GO:0070887
name: cellular response to chemical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0042221 ! response to chemical
is_a: GO:0051716 ! cellular response to stimulus
creation_date: 2009-08-27T04:41:45Z

[Term]
id: GO:0070925
name: organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0043226 ! results in assembly of organelle
relationship: RO:0002588 GO:0043226 ! results in assembly of organelle
created_by: mah
creation_date: 2009-09-15T03:00:51Z

[Term]
id: GO:0070977
name: bone maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah]
is_a: GO:0048799 ! animal organ maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0001474 ! results in maturation of bone element
relationship: BFO:0000050 GO:0060348 ! part of bone development
relationship: RO:0002299 UBERON:0001474 ! results in maturation of bone element
creation_date: 2009-10-05T04:35:31Z

[Term]
id: GO:0071166
name: ribonucleoprotein complex localization
namespace: biological_process
def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah]
synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "RNP localization" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization
creation_date: 2009-11-19T04:46:05Z

[Term]
id: GO:0071168
name: protein localization to chromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin
relationship: RO:0002339 GO:0000785 ! has target end location chromatin
creation_date: 2009-11-20T11:51:20Z

[Term]
id: GO:0071169
name: establishment of protein localization to chromatin
namespace: biological_process
def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
is_a: GO:0071168 ! protein localization to chromatin
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin
creation_date: 2009-11-20T11:52:43Z

[Term]
id: GO:0071229
name: cellular response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead.
subset: gocheck_do_not_annotate
synonym: "cellular response to acid" BROAD []
synonym: "cellular response to acid anion" RELATED []
synonym: "cellular response to oxoanion" RELATED []
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0070887 ! cellular response to chemical stimulus
creation_date: 2009-12-03T02:07:23Z

[Term]
id: GO:0071230
name: cellular response to amino acid stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]
synonym: "cellular response to amino acid" EXACT [GOC:mah]
is_a: GO:0043200 ! response to amino acid
is_a: GO:0071229 ! cellular response to acid chemical
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
creation_date: 2009-12-03T02:08:11Z

[Term]
id: GO:0071322
name: cellular response to carbohydrate stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah]
is_a: GO:0009743 ! response to carbohydrate
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
creation_date: 2009-12-10T05:13:33Z

[Term]
id: GO:0071345
name: cellular response to cytokine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]
xref: Reactome:R-HSA-9007892 "Interleukin-38 signaling"
xref: Reactome:R-HSA-9008059 "Interleukin-37 signaling"
is_a: GO:0034097 ! response to cytokine
creation_date: 2009-12-11T02:41:12Z

[Term]
id: GO:0071375
name: cellular response to peptide hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]
synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043434 ! response to peptide hormone
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:25905 ! has primary input
creation_date: 2009-12-11T03:24:18Z

[Term]
id: GO:0071383
name: cellular response to steroid hormone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]
xref: Reactome:R-HSA-3371497 "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand"
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:0071396 ! cellular response to lipid
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:26764 ! has primary input
creation_date: 2009-12-11T03:49:02Z

[Term]
id: GO:0071396
name: cellular response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]
is_a: GO:0033993 ! response to lipid
is_a: GO:0070887 ! cellular response to chemical stimulus
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
creation_date: 2009-12-11T04:37:10Z

[Term]
id: GO:0071418
name: cellular response to amine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah]
is_a: GO:0014075 ! response to amine
is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
creation_date: 2009-12-14T04:08:17Z

[Term]
id: GO:0071425
name: hematopoietic stem cell proliferation
namespace: biological_process
def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]
synonym: "hemopoietic stem cell proliferation" EXACT []
is_a: GO:0072089 ! stem cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell
relationship: BFO:0000050 GO:0030097 ! part of hemopoiesis
relationship: RO:0012003 CL:0000037 ! acts on population of hematopoietic stem cell
creation_date: 2009-12-16T10:22:52Z

[Term]
id: GO:0071495
name: cellular response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
xref: Reactome:R-HSA-9860931 "Response of endothelial cells to shear stress"
is_a: GO:0009719 ! response to endogenous stimulus
creation_date: 2009-12-18T02:25:40Z

[Term]
id: GO:0071542
name: dopaminergic neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000700 ! results in acquisition of features of dopaminergic neuron
relationship: RO:0002315 CL:0000700 ! results in acquisition of features of dopaminergic neuron
creation_date: 2010-01-12T02:28:44Z

[Term]
id: GO:0071554
name: cell wall organization or biogenesis
namespace: biological_process
alt_id: GO:0070882
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah]
subset: goslim_chembl
subset: goslim_euk_cellular_processes_ribbon
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_prokaryote_ribbon
subset: goslim_yeast
synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular cell wall organization or biogenesis" EXACT []
is_a: GO:0009987 ! cellular process
created_by: mah
creation_date: 2010-01-13T03:19:38Z

[Term]
id: GO:0071555
name: cell wall organization
namespace: biological_process
alt_id: GO:0007047
alt_id: GO:0044234
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
synonym: "cell wall organisation" EXACT []
synonym: "cell wall organisation in other organism" EXACT [GOC:mah]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "cell wall organization at cellular level" EXACT [GOC:mah]
synonym: "cell wall organization in other organism" EXACT []
synonym: "cellular cell wall organisation" EXACT []
synonym: "cellular cell wall organization" EXACT []
is_a: GO:0045229 ! external encapsulating structure organization
is_a: GO:0071554 ! cell wall organization or biogenesis
created_by: mah
creation_date: 2010-01-13T03:33:07Z

[Term]
id: GO:0071621
name: granulocyte chemotaxis
namespace: biological_process
def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph]
is_a: GO:0030595 ! leukocyte chemotaxis
is_a: GO:0097530 ! granulocyte migration
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000094 ! results in movement of granulocyte
creation_date: 2010-02-09T04:08:17Z

[Term]
id: GO:0071622
name: regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071621 ! regulates granulocyte chemotaxis
relationship: RO:0002211 GO:0071621 ! regulates granulocyte chemotaxis
creation_date: 2010-02-09T04:09:24Z

[Term]
id: GO:0071623
name: negative regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071621 ! negatively regulates granulocyte chemotaxis
relationship: RO:0002212 GO:0071621 ! negatively regulates granulocyte chemotaxis
creation_date: 2010-02-09T04:13:19Z

[Term]
id: GO:0071624
name: positive regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071621 ! positively regulates granulocyte chemotaxis
relationship: RO:0002213 GO:0071621 ! positively regulates granulocyte chemotaxis
creation_date: 2010-02-09T04:15:36Z

[Term]
id: GO:0071626
name: mastication
namespace: biological_process
def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg]
synonym: "chewing" EXACT [GOC:mah]
is_a: GO:0022600 ! digestive system process
creation_date: 2010-02-10T11:19:48Z

[Term]
id: GO:0071670
name: smooth muscle cell chemotaxis
namespace: biological_process
def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah]
is_a: GO:0014909 ! smooth muscle cell migration
is_a: GO:0060326 ! cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000192 ! results in movement of smooth muscle cell
creation_date: 2010-02-16T01:32:59Z

[Term]
id: GO:0071671
name: regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071670 ! regulates smooth muscle cell chemotaxis
relationship: RO:0002211 GO:0071670 ! regulates smooth muscle cell chemotaxis
creation_date: 2010-02-16T01:42:03Z

[Term]
id: GO:0071672
name: negative regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071670 ! negatively regulates smooth muscle cell chemotaxis
relationship: RO:0002212 GO:0071670 ! negatively regulates smooth muscle cell chemotaxis
creation_date: 2010-02-16T01:44:28Z

[Term]
id: GO:0071673
name: positive regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071670 ! positively regulates smooth muscle cell chemotaxis
relationship: RO:0002213 GO:0071670 ! positively regulates smooth muscle cell chemotaxis
creation_date: 2010-02-16T01:48:14Z

[Term]
id: GO:0071674
name: mononuclear cell migration
namespace: biological_process
def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000842 ! results in movement of mononuclear leukocyte
relationship: RO:0002565 CL:0000842 ! results in movement of mononuclear leukocyte
creation_date: 2010-02-16T02:11:00Z

[Term]
id: GO:0071675
name: regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071674 ! regulates mononuclear cell migration
relationship: RO:0002211 GO:0071674 ! regulates mononuclear cell migration
creation_date: 2010-02-16T02:11:53Z

[Term]
id: GO:0071676
name: negative regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071674 ! negatively regulates mononuclear cell migration
relationship: RO:0002212 GO:0071674 ! negatively regulates mononuclear cell migration
creation_date: 2010-02-16T02:13:55Z

[Term]
id: GO:0071677
name: positive regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "activation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071674 ! positively regulates mononuclear cell migration
relationship: RO:0002213 GO:0071674 ! positively regulates mononuclear cell migration
creation_date: 2010-02-16T02:15:29Z

[Term]
id: GO:0071692
name: protein localization to extracellular region
namespace: biological_process
def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah]
synonym: "protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "protein localization in extracellular region" EXACT []
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: GO:0033036 ! macromolecule localization
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0002339 GO:0005576 ! has target end location extracellular region
created_by: mah
creation_date: 2010-02-25T04:00:13Z

[Term]
id: GO:0071695
name: anatomical structure maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]
is_a: GO:0021700 ! developmental maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure
relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development
relationship: RO:0002299 UBERON:0000061 ! results in maturation of anatomical structure
creation_date: 2010-03-02T11:43:38Z

[Term]
id: GO:0071696
name: ectodermal placode development
namespace: biological_process
def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode
relationship: RO:0002296 UBERON:0005085 ! results in development of ectodermal placode
creation_date: 2010-03-02T11:48:01Z

[Term]
id: GO:0071697
name: ectodermal placode morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode
relationship: BFO:0000050 GO:0071696 ! part of ectodermal placode development
relationship: RO:0002298 UBERON:0005085 ! results in morphogenesis of ectodermal placode
creation_date: 2010-03-02T11:49:51Z

[Term]
id: GO:0071705
name: nitrogen compound transport
namespace: biological_process
def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
subset: gocheck_obsoletion_candidate
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
created_by: mah
creation_date: 2010-03-08T03:56:28Z

[Term]
id: GO:0071709
name: membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0016020 ! results in assembly of membrane
relationship: BFO:0000050 GO:0044091 ! part of membrane biogenesis
relationship: RO:0002588 GO:0016020 ! results in assembly of membrane
created_by: mah
creation_date: 2010-03-10T11:19:17Z

[Term]
id: GO:0071711
name: basement membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer.
synonym: "basement membrane organisation" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005604 ! results in organization of basement membrane
relationship: RO:0002592 GO:0005604 ! results in organization of basement membrane
creation_date: 2010-03-10T11:57:10Z

[Term]
id: GO:0071763
name: nuclear membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah]
synonym: "nuclear membrane organisation" EXACT [GOC:mah]
synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0031965 ! results in organization of nuclear membrane
relationship: BFO:0000050 GO:0006998 ! part of nuclear envelope organization
relationship: RO:0002592 GO:0031965 ! results in organization of nuclear membrane
created_by: mah
creation_date: 2010-03-29T03:59:35Z

[Term]
id: GO:0071764
name: nuclear outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah]
synonym: "nuclear outer membrane organisation" EXACT [GOC:mah]
synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane
relationship: RO:0002592 GO:0005640 ! results in organization of nuclear outer membrane
creation_date: 2010-03-29T04:03:37Z

[Term]
id: GO:0071806
name: protein transmembrane transport
namespace: biological_process
def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "protein membrane transport" EXACT []
is_a: GO:0015031 ! protein transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
creation_date: 2010-09-03T02:54:26Z

[Term]
id: GO:0071826
name: protein-RNA complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah]
synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organization" EXACT []
synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah]
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex
relationship: RO:0002592 GO:1990904 ! results in organization of ribonucleoprotein complex
created_by: mah
creation_date: 2010-09-08T10:10:35Z

[Term]
id: GO:0071840
name: cellular component organization or biogenesis
namespace: biological_process
alt_id: GO:0071841
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular component organization or biogenesis at cellular level" EXACT []
is_a: GO:0009987 ! cellular process
created_by: mah
creation_date: 2010-09-10T01:39:16Z

[Term]
id: GO:0071867
name: response to monoamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah]
synonym: "response to monoamine stimulus" EXACT [GOC:dos]
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:63534 ! has primary input
relationship: RO:0004009 CHEBI:63534 ! has primary input
creation_date: 2010-09-13T02:36:37Z

[Term]
id: GO:0071868
name: cellular response to monoamine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah]
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:63534 ! has primary input
creation_date: 2010-09-13T02:38:52Z

[Term]
id: GO:0071869
name: response to catecholamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah]
synonym: "response to catecholamine stimulus" EXACT [GOC:dos]
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
relationship: RO:0004009 CHEBI:33567 ! has primary input
creation_date: 2010-09-13T02:51:13Z

[Term]
id: GO:0071870
name: cellular response to catecholamine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah]
is_a: GO:0071868 ! cellular response to monoamine stimulus
is_a: GO:0071869 ! response to catecholamine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
creation_date: 2010-09-13T02:54:50Z

[Term]
id: GO:0071873
name: response to norepinephrine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "response to noradrenaline stimulus" EXACT [GOC:mah]
synonym: "response to norepinephrine stimulus" EXACT [GOC:dos]
is_a: GO:0071869 ! response to catecholamine
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:72587 ! has primary input
relationship: RO:0004009 CHEBI:72587 ! has primary input
creation_date: 2010-09-13T03:31:53Z

[Term]
id: GO:0071874
name: cellular response to norepinephrine stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:0071873 ! response to norepinephrine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:72587 ! has primary input
creation_date: 2010-09-13T03:33:32Z

[Term]
id: GO:0071887
name: leukocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "leukocyte apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000738 ! occurs in leukocyte
relationship: BFO:0000066 CL:0000738 ! occurs in leukocyte
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>
creation_date: 2010-09-14T12:44:09Z

[Term]
id: GO:0071888
name: macrophage apoptotic process
namespace: biological_process
def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation-induced cell death" RELATED [GOC:yaf]
synonym: "AICD" RELATED [GOC:yaf]
synonym: "macrophage apoptosis" NARROW []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
is_a: GO:0071887 ! leukocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage
relationship: BFO:0000066 CL:0000235 ! occurs in macrophage
creation_date: 2010-09-14T12:50:40Z

[Term]
id: GO:0071897
name: DNA biosynthetic process
namespace: biological_process
def: "The biosynthetic process resulting in the formation of DNA." [GOC:mah]
synonym: "DNA anabolism" EXACT [GOC:mah]
synonym: "DNA biosynthesis" EXACT [GOC:mah]
synonym: "DNA formation" EXACT [GOC:mah]
synonym: "DNA synthesis" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0141187 ! nucleic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:16991 ! has primary output
relationship: RO:0004008 CHEBI:16991 ! has primary output
creation_date: 2010-09-15T02:14:33Z

[Term]
id: GO:0071944
name: cell periphery
namespace: cellular_component
def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]
subset: goslim_flybase_ribbon
is_a: GO:0110165 ! cellular anatomical structure
created_by: mah
creation_date: 2010-10-04T01:51:47Z

[Term]
id: GO:0071953
name: elastic fiber
namespace: cellular_component
def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620]
synonym: "elastic fibre" EXACT [GOC:mah]
synonym: "elastin fiber" EXACT [GOC:BHF]
is_a: GO:0099512 ! supramolecular fiber
relationship: BFO:0000050 GO:0031012 ! part of extracellular matrix
creation_date: 2010-10-11T11:44:57Z

[Term]
id: GO:0071971
name: extracellular exosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458]
synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome
relationship: BFO:0000050 GO:0097734 ! part of extracellular exosome biogenesis
relationship: RO:0002588 GO:0070062 ! results in assembly of extracellular exosome
creation_date: 2010-10-18T03:44:18Z

[Term]
id: GO:0072089
name: stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000034 ! acts on population of stem cell
relationship: BFO:0000051 GO:0017145 ! has part stem cell division
relationship: RO:0012003 CL:0000034 ! acts on population of stem cell
creation_date: 2010-02-08T02:03:36Z

[Term]
id: GO:0072091
name: regulation of stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072089 ! regulates stem cell proliferation
relationship: RO:0002211 GO:0072089 ! regulates stem cell proliferation
creation_date: 2010-02-08T02:09:03Z

[Term]
id: GO:0072132
name: mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme
relationship: BFO:0000050 GO:0009887 ! part of animal organ morphogenesis
relationship: BFO:0000050 GO:0060485 ! part of mesenchyme development
relationship: RO:0002298 UBERON:0003104 ! results in morphogenesis of mesenchyme
creation_date: 2010-02-22T02:17:15Z

[Term]
id: GO:0072175
name: epithelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10]
is_a: GO:0035148 ! tube formation
intersection_of: GO:0035148 ! tube formation
intersection_of: RO:0002297 UBERON:0003914 ! results in formation of epithelial tube
relationship: BFO:0000050 GO:0060562 ! part of epithelial tube morphogenesis
relationship: RO:0002297 UBERON:0003914 ! results in formation of epithelial tube
creation_date: 2010-02-26T02:15:40Z

[Term]
id: GO:0072201
name: negative regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation
relationship: RO:0002212 GO:0010463 ! negatively regulates mesenchymal cell proliferation
creation_date: 2010-03-01T03:43:29Z

[Term]
id: GO:0072329
name: monocarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion
relationship: RO:0004009 CHEBI:35757 ! has primary input monocarboxylic acid anion
creation_date: 2010-11-02T04:41:55Z

[Term]
id: GO:0072330
name: monocarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]
synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah]
synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah]
synonym: "monocarboxylic acid formation" EXACT [GOC:mah]
synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:35757 ! has primary output monocarboxylic acid anion
relationship: RO:0004008 CHEBI:35757 ! has primary output monocarboxylic acid anion
creation_date: 2010-11-02T04:51:32Z

[Term]
id: GO:0072359
name: circulatory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]
subset: goslim_drosophila
synonym: "cardiovascular system development" NARROW []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001009 ! results in development of circulatory system
relationship: RO:0002296 UBERON:0001009 ! results in development of circulatory system
creation_date: 2010-11-16T11:27:39Z

[Term]
id: GO:0072360
name: vascular cord development
namespace: biological_process
def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0006965 ! results in development of vascular cord
relationship: BFO:0000050 GO:0072359 ! part of circulatory system development
relationship: RO:0002296 UBERON:0006965 ! results in development of vascular cord
creation_date: 2010-11-16T11:46:55Z

[Term]
id: GO:0072384
name: organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]
synonym: "microtubule-based organelle localization" EXACT [GOC:rl]
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0043226 ! has primary input organelle
creation_date: 2010-12-01T04:59:11Z

[Term]
id: GO:0072537
name: fibroblast activation
namespace: biological_process
def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: RO:0004009 CL:0000057 ! has primary input fibroblast
relationship: RO:0004009 CL:0000057 ! has primary input fibroblast
creation_date: 2011-01-14T04:35:08Z

[Term]
id: GO:0072577
name: endothelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptosis of endothelial cells" EXACT [GOC:mah]
synonym: "endothelial cell apoptosis" NARROW []
synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "killing of endothelial cells" EXACT [GOC:mah]
synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah]
synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000115 ! occurs in endothelial cell
relationship: BFO:0000066 CL:0000115 ! occurs in endothelial cell
creation_date: 2011-02-02T03:56:24Z

[Term]
id: GO:0072592
name: oxygen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah]
synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263]
synonym: "oxygen metabolism" EXACT [GOC:mah]
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:15379 ! has primary input or output
relationship: RO:0004007 CHEBI:15379 ! has primary input or output
creation_date: 2011-02-11T10:46:51Z

[Term]
id: GO:0072593
name: reactive oxygen species metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah]
synonym: "reactive oxygen species metabolism" EXACT [GOC:mah]
synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah]
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26523 ! has primary input or output reactive oxygen species
relationship: RO:0004007 CHEBI:26523 ! has primary input or output reactive oxygen species
created_by: mah
creation_date: 2011-02-11T10:50:06Z

[Term]
id: GO:0072594
name: establishment of protein localization to organelle
namespace: biological_process
def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
is_a: GO:0045184 ! establishment of protein localization
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0043226 ! has target end location organelle
created_by: mah
creation_date: 2011-02-14T01:56:51Z

[Term]
id: GO:0072595
name: maintenance of protein localization in organelle
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah]
synonym: "maintenance of protein localization to organelle" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 GO:0043226 ! occurs in organelle
relationship: BFO:0000050 GO:0033365 ! part of protein localization to organelle
relationship: BFO:0000066 GO:0043226 ! occurs in organelle
creation_date: 2011-02-14T02:09:13Z

[Term]
id: GO:0072596
name: establishment of protein localization to chloroplast
namespace: biological_process
def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah]
synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:0072598 ! protein localization to chloroplast
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0009507 ! has target end location chloroplast
creation_date: 2011-02-14T02:16:13Z

[Term]
id: GO:0072597
name: maintenance of protein location in chloroplast
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 GO:0009507 ! occurs in chloroplast
relationship: BFO:0000050 GO:0072598 ! part of protein localization to chloroplast
relationship: BFO:0000066 GO:0009507 ! occurs in chloroplast
creation_date: 2011-02-14T02:17:48Z

[Term]
id: GO:0072598
name: protein localization to chloroplast
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd]
synonym: "protein localisation to chloroplast" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0009507 ! has target end location chloroplast
relationship: RO:0002339 GO:0009507 ! has target end location chloroplast
creation_date: 2011-02-14T02:20:30Z

[Term]
id: GO:0072655
name: establishment of protein localization to mitochondrion
namespace: biological_process
def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]
synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrion" EXACT []
is_a: GO:0070585 ! protein localization to mitochondrion
is_a: GO:0072594 ! establishment of protein localization to organelle
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0005739 ! has target end location mitochondrion
creation_date: 2011-02-14T02:28:54Z

[Term]
id: GO:0072656
name: maintenance of protein location in mitochondrion
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0070585 ! part of protein localization to mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
creation_date: 2011-02-14T02:30:43Z

[Term]
id: GO:0072657
name: protein localization to membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]
subset: goslim_prokaryote
synonym: "protein localisation in membrane" EXACT [GOC:mah]
synonym: "protein localization in membrane" EXACT []
is_a: GO:0008104 ! intracellular protein localization
is_a: GO:0051668 ! localization within membrane
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0016020 ! has target end location membrane
created_by: mah
creation_date: 2011-02-14T02:35:18Z

[Term]
id: GO:0072659
name: protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0072661
alt_id: GO:0090002
def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]
subset: goslim_generic
subset: goslim_pombe
synonym: "protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "protein localization in plasma membrane" RELATED []
synonym: "protein targeting to plasma membrane" RELATED []
synonym: "protein-plasma membrane targeting" RELATED [GOC:mah]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure
intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure
relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane
created_by: tb
creation_date: 2009-07-10T10:29:23Z

[Term]
id: GO:0072665
name: protein localization to vacuole
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd]
synonym: "protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole
relationship: RO:0002339 GO:0005773 ! has target end location vacuole
created_by: mah
creation_date: 2011-02-14T02:55:35Z

[Term]
id: GO:0072666
name: establishment of protein localization to vacuole
namespace: biological_process
def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah]
synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
is_a: GO:0072665 ! protein localization to vacuole
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole
created_by: mah
creation_date: 2011-02-14T02:56:29Z

[Term]
id: GO:0072667
name: maintenance of protein location in vacuole
namespace: biological_process
def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0072595 ! maintenance of protein localization in organelle
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: BFO:0000066 GO:0005773 ! occurs in vacuole
relationship: BFO:0000050 GO:0072665 ! part of protein localization to vacuole
relationship: BFO:0000066 GO:0005773 ! occurs in vacuole
creation_date: 2011-02-14T02:56:57Z

[Term]
id: GO:0072674
name: multinuclear osteoclast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016]
synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah]
synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah]
is_a: GO:0030316 ! osteoclast differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000779 ! results in acquisition of features of multinuclear osteoclast
relationship: RO:0002315 CL:0000779 ! results in acquisition of features of multinuclear osteoclast
creation_date: 2011-02-22T02:10:38Z

[Term]
id: GO:0072676
name: lymphocyte migration
namespace: biological_process
def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah]
is_a: GO:0071674 ! mononuclear cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000542 ! results in movement of lymphocyte
relationship: RO:0002565 CL:0000542 ! results in movement of lymphocyte
creation_date: 2011-02-22T03:38:12Z

[Term]
id: GO:0072678
name: T cell migration
namespace: biological_process
def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah]
synonym: "T lymphocyte migration" EXACT [CL:0000084]
synonym: "T-cell migration" EXACT [CL:0000084]
synonym: "T-lymphocyte migration" EXACT [CL:0000084]
is_a: GO:0072676 ! lymphocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000084 ! results in movement of T cell
relationship: RO:0002565 CL:0000084 ! results in movement of T cell
creation_date: 2011-02-22T03:40:40Z

[Term]
id: GO:0072697
name: protein localization to cell cortex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah]
synonym: "protein localisation to cell cortex" EXACT [GOC:mah]
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005938 ! has target end location cell cortex
relationship: RO:0002339 GO:0005938 ! has target end location cell cortex
created_by: mah
creation_date: 2012-04-11T01:16:33Z

[Term]
id: GO:0072698
name: protein localization to microtubule cytoskeleton
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah]
synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah]
is_a: GO:0044380 ! protein localization to cytoskeleton
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton
relationship: RO:0002339 GO:0015630 ! has target end location microtubule cytoskeleton
creation_date: 2012-04-11T01:19:35Z

[Term]
id: GO:0075009
name: germ tube formation
namespace: biological_process
def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "germ tube formation on or near host" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: BFO:0000050 GO:0009847 ! part of spore germination

[Term]
id: GO:0075010
name: regulation of germ tube formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0075009 ! regulates germ tube formation
relationship: RO:0002211 GO:0075009 ! regulates germ tube formation

[Term]
id: GO:0075015
name: formation of infection structure
namespace: biological_process
def: "The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "formation by symbiont of infection structure on or near host" RELATED []
synonym: "formation of host infection structure" EXACT []
synonym: "formation of host penetration structure" RELATED []
synonym: "formation of infection structure on or near host" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: BFO:0000050 GO:0044409 ! part of entry into host

[Term]
id: GO:0075053
name: penetration peg formation
namespace: biological_process
alt_id: GO:0075057
def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of symbiont penetration peg for entry into host" RELATED []
synonym: "initiation of symbiont penetration peg" NARROW []
synonym: "symbiont penetration peg formation for entry into host" RELATED []
synonym: "symbiont penetration peg initiation" NARROW []
is_a: GO:0075015 ! formation of infection structure

[Term]
id: GO:0075054
name: modulation of penetration peg formation
namespace: biological_process
alt_id: GO:0075058
def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "modulation of symbiont penetration peg formation for entry into host" NARROW []
synonym: "modulation of symbiont penetration peg initiation" NARROW []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0052372 ! modulation by symbiont of entry into host
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0075053 ! regulates penetration peg formation
relationship: RO:0002211 GO:0075053 ! regulates penetration peg formation

[Term]
id: GO:0080090
name: regulation of primary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044238 ! regulates primary metabolic process
relationship: RO:0002211 GO:0044238 ! regulates primary metabolic process
created_by: dhl
creation_date: 2009-04-22T04:30:52Z

[Term]
id: GO:0080134
name: regulation of response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006950 ! regulates response to stress
relationship: RO:0002211 GO:0006950 ! regulates response to stress
created_by: dhl
creation_date: 2009-05-06T04:51:28Z

[Term]
id: GO:0080135
name: regulation of cellular response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0033554 ! regulates cellular response to stress
relationship: RO:0002211 GO:0033554 ! regulates cellular response to stress
created_by: dhl
creation_date: 2009-05-06T05:02:52Z

[Term]
id: GO:0080154
name: regulation of fertilization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994]
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009566 ! regulates fertilization
relationship: RO:0002211 GO:0009566 ! regulates fertilization
creation_date: 2010-09-01T03:44:27Z

[Term]
id: GO:0080171
name: lytic vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380]
synonym: "lytic vacuolar assembly" NARROW []
synonym: "lytic vacuole biogenesis" RELATED []
synonym: "lytic vacuole organisation" EXACT []
synonym: "lytic vacuole organization and biogenesis" RELATED []
is_a: GO:0007033 ! vacuole organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0000323 ! results in organization of lytic vacuole
relationship: RO:0002592 GO:0000323 ! results in organization of lytic vacuole
creation_date: 2011-04-25T04:40:46Z

[Term]
id: GO:0085029
name: extracellular matrix assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix
relationship: RO:0002588 GO:0031012 ! results in assembly of extracellular matrix
creation_date: 2010-07-14T12:52:49Z

[Term]
id: GO:0085030
name: mutualism
namespace: biological_process
def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism." [GOC:pdt]
synonym: "mutualism" RELATED []
is_a: GO:0044403 ! biological process involved in symbiotic interaction
created_by: jl
creation_date: 2010-07-27T01:25:21Z

[Term]
id: GO:0086001
name: cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0001508 ! action potential
intersection_of: GO:0001508 ! action potential
intersection_of: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell
relationship: BFO:0000066 CL:0000746 ! occurs in cardiac muscle cell
creation_date: 2011-11-10T07:45:11Z

[Term]
id: GO:0086015
name: SA node cell action potential
namespace: biological_process
def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell action potential" EXACT []
synonym: "SAN cardiac muscle cell action potential" EXACT []
synonym: "sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0001508 ! action potential
intersection_of: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node
relationship: BFO:0000050 GO:0086018 ! part of SA node cell to atrial cardiac muscle cell signaling
relationship: BFO:0000066 CL:1000409 ! occurs in myocyte of sinoatrial node
creation_date: 2011-11-10T08:50:15Z

[Term]
id: GO:0086016
name: AV node cell action potential
namespace: biological_process
def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0001508 ! action potential
intersection_of: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node
relationship: BFO:0000050 GO:0086027 ! part of AV node cell to bundle of His cell signaling
relationship: BFO:0000066 CL:1000410 ! occurs in myocyte of atrioventricular node
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0086017
name: Purkinje myocyte action potential
namespace: biological_process
def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0001508 ! action potential
intersection_of: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte
relationship: BFO:0000050 GO:0086029 ! part of Purkinje myocyte to ventricular cardiac muscle cell signaling
relationship: BFO:0000066 CL:0002068 ! occurs in Purkinje myocyte
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0086018
name: SA node cell to atrial cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW []
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication
creation_date: 2011-11-10T09:15:01Z

[Term]
id: GO:0086019
name: cell-cell signaling involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0086065 ! cell communication involved in cardiac conduction
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: BFO:0000050 GO:0061337 ! part of cardiac conduction
creation_date: 2011-11-16T03:43:52Z

[Term]
id: GO:0086027
name: AV node cell to bundle of His cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node to bundle of His cell signaling" EXACT []
synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086067 ! AV node cell to bundle of His cell communication
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086029
name: Purkinje myocyte to ventricular cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0002068 ! has start location Purkinje myocyte
intersection_of: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell
relationship: RO:0002231 CL:0002068 ! has start location Purkinje myocyte
relationship: RO:0002232 CL:2000046 ! has end location ventricular cardiac muscle cell
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086065
name: cell communication involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007154 ! cell communication
intersection_of: GO:0007154 ! cell communication
intersection_of: BFO:0000050 GO:0061337 ! part of cardiac conduction
relationship: BFO:0000050 GO:0061337 ! part of cardiac conduction
creation_date: 2011-11-22T08:57:02Z

[Term]
id: GO:0086067
name: AV node cell to bundle of His cell communication
namespace: biological_process
def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell to bundle of His cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
creation_date: 2011-11-22T09:11:44Z

[Term]
id: GO:0086068
name: Purkinje myocyte to ventricular cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086065 ! cell communication involved in cardiac conduction
creation_date: 2011-11-22T09:14:49Z

[Term]
id: GO:0086070
name: SA node cell to atrial cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
creation_date: 2011-11-22T09:32:45Z

[Term]
id: GO:0086093
name: G protein-coupled acetylcholine receptor signaling pathway involved in heart process
namespace: biological_process
def: "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in heart process" EXACT []
synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11]
synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway
is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process
intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway
intersection_of: BFO:0000050 GO:0003015 ! part of heart process

[Term]
id: GO:0086103
name: G protein-coupled receptor signaling pathway involved in heart process
namespace: biological_process
def: "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402]
synonym: "G-protein coupled receptor signaling pathway involved in heart process" EXACT [GOC:bf]
synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf]
synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf]
synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf]
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
intersection_of: GO:0007186 ! G protein-coupled receptor signaling pathway
intersection_of: BFO:0000050 GO:0003015 ! part of heart process
relationship: BFO:0000050 GO:0003015 ! part of heart process
creation_date: 2012-03-19T01:28:23Z

[Term]
id: GO:0089704
name: L-glutamate transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0002338 GO:0005775 ! has target start location vacuolar lumen
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0004009 CHEBI:29985 ! has primary input

[Term]
id: GO:0089718
name: amino acid import across plasma membrane
namespace: biological_process
def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]
synonym: "amino acid import into cell" EXACT []
synonym: "amino acid transmembrane import" BROAD []
synonym: "L-amino acid import" BROAD []
synonym: "L-amino acid uptake" NARROW []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0098739 ! import across plasma membrane
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:35238 ! has primary input amino-acid zwitterion
creation_date: 2012-11-14T14:21:41Z

[Term]
id: GO:0090025
name: regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002548 ! regulates monocyte chemotaxis
relationship: RO:0002211 GO:0002548 ! regulates monocyte chemotaxis
creation_date: 2009-08-03T10:17:03Z

[Term]
id: GO:0090026
name: positive regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:0090025 ! regulation of monocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002548 ! positively regulates monocyte chemotaxis
relationship: RO:0002213 GO:0002548 ! positively regulates monocyte chemotaxis
creation_date: 2009-08-03T10:18:54Z

[Term]
id: GO:0090027
name: negative regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:0090025 ! regulation of monocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002548 ! negatively regulates monocyte chemotaxis
relationship: RO:0002212 GO:0002548 ! negatively regulates monocyte chemotaxis
creation_date: 2009-08-03T10:19:40Z

[Term]
id: GO:0090063
name: positive regulation of microtubule nucleation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031116 ! positive regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation
relationship: RO:0002213 GO:0007020 ! positively regulates microtubule nucleation
creation_date: 2009-08-12T11:33:09Z

[Term]
id: GO:0090068
name: positive regulation of cell cycle process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045787 ! positive regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0022402 ! positively regulates cell cycle process
relationship: RO:0002213 GO:0022402 ! positively regulates cell cycle process
creation_date: 2009-09-09T11:39:52Z

[Term]
id: GO:0090069
name: regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042254 ! regulates ribosome biogenesis
relationship: RO:0002211 GO:0042254 ! regulates ribosome biogenesis
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090070
name: positive regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis
relationship: RO:0002213 GO:0042254 ! positively regulates ribosome biogenesis
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090071
name: negative regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis
relationship: RO:0002212 GO:0042254 ! negatively regulates ribosome biogenesis
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090087
name: regulation of peptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015833 ! regulates peptide transport
relationship: RO:0002211 GO:0015833 ! regulates peptide transport
created_by: tb
creation_date: 2009-10-23T11:21:38Z

[Term]
id: GO:0090091
name: positive regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly
relationship: RO:0002213 GO:0022617 ! positively regulates extracellular matrix disassembly
creation_date: 2009-11-04T10:03:25Z

[Term]
id: GO:0090130
name: tissue migration
namespace: biological_process
def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process
creation_date: 2009-12-07T03:13:55Z

[Term]
id: GO:0090132
name: epithelium migration
namespace: biological_process
def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration
creation_date: 2009-12-07T03:19:34Z

[Term]
id: GO:0090138
name: regulation of actin cytoskeleton organization by cell-cell adhesion
namespace: biological_process
def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: RO:0002211 GO:0030036 ! regulates actin cytoskeleton organization
creation_date: 2009-12-08T02:05:00Z

[Term]
id: GO:0090139
name: mitochondrial chromosome packaging
namespace: biological_process
def: "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mitochondrial DNA packaging" EXACT []
is_a: GO:0051276 ! chromosome organization
intersection_of: GO:0051276 ! chromosome organization
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
creation_date: 2009-12-08T02:12:19Z

[Term]
id: GO:0090140
name: regulation of mitochondrial fission
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000266 ! regulates mitochondrial fission
relationship: RO:0002211 GO:0000266 ! regulates mitochondrial fission
creation_date: 2009-12-08T02:20:48Z

[Term]
id: GO:0090141
name: positive regulation of mitochondrial fission
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000266 ! positively regulates mitochondrial fission
relationship: RO:0002213 GO:0000266 ! positively regulates mitochondrial fission
creation_date: 2009-12-08T02:20:48Z

[Term]
id: GO:0090150
name: establishment of protein localization to membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in membrane" EXACT []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0072657 ! protein localization to membrane
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0016020 ! has target end location membrane
created_by: tb
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090151
name: establishment of protein localization to mitochondrial membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrial membrane" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0072655 ! establishment of protein localization to mitochondrion
is_a: GO:0090150 ! establishment of protein localization to membrane
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0031966 ! has target end location mitochondrial membrane
relationship: RO:0002339 GO:0031966 ! has target end location mitochondrial membrane
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090152
name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah]
synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT []
is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane
intersection_of: GO:0090151 ! establishment of protein localization to mitochondrial membrane
intersection_of: BFO:0000050 GO:0000266 ! part of mitochondrial fission
relationship: BFO:0000050 GO:0000266 ! part of mitochondrial fission
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090160
name: Golgi to lysosome transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006896 ! Golgi to vacuole transport
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016482 ! cytosolic transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
intersection_of: RO:0002338 GO:0005794 ! has target start location Golgi apparatus
intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome
relationship: RO:0002339 GO:0005764 ! has target end location lysosome
creation_date: 2009-12-08T08:35:13Z

[Term]
id: GO:0090162
name: establishment of epithelial cell polarity
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell
relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell
creation_date: 2009-12-08T08:58:27Z

[Term]
id: GO:0090166
name: Golgi disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus disassembly" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus
relationship: BFO:0000050 GO:0048313 ! part of Golgi inheritance
relationship: RO:0002590 GO:0005794 ! results in disassembly of Golgi apparatus
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090168
name: Golgi reassembly
namespace: biological_process
def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus reassembly" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0022607 ! cellular component assembly
relationship: BFO:0000050 GO:0048313 ! part of Golgi inheritance
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090170
name: regulation of Golgi inheritance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:1903358 ! regulation of Golgi organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048313 ! regulates Golgi inheritance
relationship: RO:0002211 GO:0048313 ! regulates Golgi inheritance
creation_date: 2009-12-11T10:21:59Z

[Term]
id: GO:0090171
name: chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002299 CL:0000138 ! results in maturation of chondrocyte
relationship: BFO:0000050 GO:0002063 ! part of chondrocyte development
relationship: RO:0002299 CL:0000138 ! results in maturation of chondrocyte
creation_date: 2009-12-11T10:36:02Z

[Term]
id: GO:0090174
name: organelle membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048284 ! organelle fusion
is_a: GO:0061025 ! membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: RO:0012008 GO:0031090 ! results in fusion of organelle membrane
relationship: RO:0012008 GO:0031090 ! results in fusion of organelle membrane
creation_date: 2009-12-11T11:44:58Z

[Term]
id: GO:0090257
name: regulation of muscle system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003012 ! regulates muscle system process
relationship: RO:0002211 GO:0003012 ! regulates muscle system process
creation_date: 2010-02-03T11:48:13Z

[Term]
id: GO:0090258
name: negative regulation of mitochondrial fission
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb]
synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000266 ! negatively regulates mitochondrial fission
relationship: RO:0002212 GO:0000266 ! negatively regulates mitochondrial fission
creation_date: 2010-02-03T04:05:32Z

[Term]
id: GO:0090276
name: regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030072 ! regulates peptide hormone secretion
relationship: RO:0002211 GO:0030072 ! regulates peptide hormone secretion
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090277
name: positive regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion
relationship: RO:0002213 GO:0030072 ! positively regulates peptide hormone secretion
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090278
name: negative regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion
relationship: RO:0002212 GO:0030072 ! negatively regulates peptide hormone secretion
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090289
name: regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002158 ! regulates osteoclast proliferation
relationship: RO:0002211 GO:0002158 ! regulates osteoclast proliferation
creation_date: 2010-02-18T03:11:03Z

[Term]
id: GO:0090290
name: positive regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002158 ! positively regulates osteoclast proliferation
relationship: RO:0002213 GO:0002158 ! positively regulates osteoclast proliferation
creation_date: 2010-02-18T03:11:03Z

[Term]
id: GO:0090291
name: negative regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002158 ! negatively regulates osteoclast proliferation
relationship: RO:0002212 GO:0002158 ! negatively regulates osteoclast proliferation
creation_date: 2010-02-18T03:11:03Z

[Term]
id: GO:0090299
name: regulation of neural crest formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014029 ! regulates neural crest formation
relationship: RO:0002211 GO:0014029 ! regulates neural crest formation
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090300
name: positive regulation of neural crest formation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:0090299 ! regulation of neural crest formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014029 ! positively regulates neural crest formation
relationship: RO:0002213 GO:0014029 ! positively regulates neural crest formation
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090301
name: negative regulation of neural crest formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:0090299 ! regulation of neural crest formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014029 ! negatively regulates neural crest formation
relationship: RO:0002212 GO:0014029 ! negatively regulates neural crest formation
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090304
name: nucleic acid metabolic process
namespace: biological_process
def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33696 ! has primary input or output nucleic acid
relationship: RO:0004007 CHEBI:33696 ! has primary input or output nucleic acid
created_by: tb
creation_date: 2010-04-07T10:18:47Z

[Term]
id: GO:0090316
name: positive regulation of intracellular protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051222 ! positive regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport
relationship: RO:0002213 GO:0006886 ! positively regulates intracellular protein transport
creation_date: 2010-04-16T03:45:07Z

[Term]
id: GO:0090317
name: negative regulation of intracellular protein transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051224 ! negative regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport
relationship: RO:0002212 GO:0006886 ! negatively regulates intracellular protein transport
creation_date: 2010-04-16T03:45:07Z

[Term]
id: GO:0090425
name: acinar cell differentiation
namespace: biological_process
def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb]
is_a: GO:0002067 ! glandular epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell
relationship: RO:0002315 CL:0000622 ! results in acquisition of features of acinar cell
creation_date: 2012-05-04T09:24:48Z

[Term]
id: GO:0090435
name: protein localization to nuclear envelope
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb]
synonym: "protein localization in nuclear envelope" EXACT []
is_a: GO:0034504 ! protein localization to nucleus
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005635 ! has target end location nuclear envelope
relationship: RO:0002339 GO:0005635 ! has target end location nuclear envelope
created_by: tb
creation_date: 2012-07-30T01:50:41Z

[Term]
id: GO:0090454
name: glutamate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb]
synonym: "vacuolar glutamate import" RELATED [GOC:tb]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
intersection_of: GO:0015800 ! acidic amino acid transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:14321 ! has primary input
relationship: RO:0004009 CHEBI:14321 ! has primary input
creation_date: 2012-09-24T14:12:46Z

[Term]
id: GO:0090493
name: catecholamine uptake
namespace: biological_process
def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
relationship: RO:0002338 GO:0005576 ! has target start location extracellular region
relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
creation_date: 2012-10-17T11:06:17Z

[Term]
id: GO:0090494
name: dopamine uptake
namespace: biological_process
def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0090493 ! catecholamine uptake
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
creation_date: 2012-10-17T11:12:09Z

[Term]
id: GO:0090497
name: mesenchymal cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0008019 ! results in movement of mesenchymal cell
relationship: RO:0002565 CL:0008019 ! results in movement of mesenchymal cell
creation_date: 2012-10-17T12:08:17Z

[Term]
id: GO:0090515
name: L-glutamate transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al]
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0090454 ! glutamate transmembrane import into vacuole
intersection_of: GO:0015800 ! acidic amino acid transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
creation_date: 2012-12-14T11:25:52Z

[Term]
id: GO:0090596
name: sensory organ morphogenesis
namespace: biological_process
def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ
relationship: BFO:0000050 GO:0007423 ! part of sensory organ development
relationship: RO:0002298 UBERON:0000020 ! results in morphogenesis of sense organ
creation_date: 2014-08-22T13:23:20Z

[Term]
id: GO:0090685
name: RNA localization to nucleus
namespace: biological_process
def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931]
synonym: "RNA localisation to nucleus" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization
intersection_of: GO:0006403 ! RNA localization
intersection_of: RO:0002339 GO:0005634 ! has target end location nucleus
relationship: RO:0002339 GO:0005634 ! has target end location nucleus
created_by: tb
creation_date: 2016-07-19T17:00:49Z

[Term]
id: GO:0090741
name: pigment granule membrane
namespace: cellular_component
def: "Any membrane that is part of a pigment granule." [PMID:11294610]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0048770 ! bounding layer of pigment granule
relationship: RO:0002007 GO:0048770 ! bounding layer of pigment granule
creation_date: 2017-05-16T22:33:39Z

[Term]
id: GO:0095500
name: acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "acetylcholine receptor signalling pathway" EXACT []
is_a: GO:0098926 ! postsynaptic signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002224 GO:0015464 ! starts with acetylcholine receptor activity
relationship: BFO:0000050 GO:1905145 ! part of cellular response to acetylcholine
relationship: RO:0002224 GO:0015464 ! starts with acetylcholine receptor activity

[Term]
id: GO:0097014
name: ciliary plasm
namespace: cellular_component
def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm".
synonym: "cilial cytoplasm" RELATED []
synonym: "ciliary cytoplasm" RELATED []
synonym: "cilium cytoplasm" RELATED []
synonym: "cilium plasm" EXACT []
synonym: "microtubule-based flagellar cytoplasm" RELATED []
synonym: "microtubule-based flagellar matrix" NARROW []
synonym: "microtubule-based flagellum cytoplasm" RELATED []
synonym: "microtubule-based flagellum matrix" NARROW []
is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0005929 ! part of cilium
relationship: BFO:0000050 GO:0005929 ! part of cilium
creation_date: 2011-03-23T01:52:31Z

[Term]
id: GO:0097026
name: dendritic cell dendrite assembly
namespace: biological_process
def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351]
comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals.
synonym: "dendritic extension" BROAD []
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0097511 ! results in assembly of dendritic cell dendrite
relationship: RO:0002588 GO:0097511 ! results in assembly of dendritic cell dendrite
creation_date: 2011-03-31T04:52:53Z

[Term]
id: GO:0097028
name: dendritic cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:1903131 ! mononuclear cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000451 ! results in acquisition of features of dendritic cell
relationship: RO:0002315 CL:0000451 ! results in acquisition of features of dendritic cell
creation_date: 2011-04-01T10:08:42Z

[Term]
id: GO:0097048
name: dendritic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]
synonym: "dendritic cell apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell
relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell
creation_date: 2011-05-04T02:18:59Z

[Term]
id: GO:0097049
name: motor neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086]
synonym: "motoneuron apoptosis" EXACT []
synonym: "motor neuron apoptosis" NARROW []
is_a: GO:0051402 ! neuron apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000100 ! occurs in motor neuron
relationship: BFO:0000066 CL:0000100 ! occurs in motor neuron
creation_date: 2011-05-04T02:21:43Z

[Term]
id: GO:0097054
name: L-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf]
synonym: "L-glutamate anabolism" EXACT []
synonym: "L-glutamate biosynthesis" EXACT []
synonym: "L-glutamate formation" EXACT []
synonym: "L-glutamate synthesis" EXACT []
is_a: GO:0006537 ! glutamate biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:29985 ! has primary output
relationship: RO:0004008 CHEBI:29985 ! has primary output
creation_date: 2011-05-24T04:30:38Z

[Term]
id: GO:0097060
name: synaptic membrane
namespace: cellular_component
def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]
subset: goslim_synapse
is_a: GO:0098590 ! plasma membrane region
intersection_of: GO:0098590 ! plasma membrane region
intersection_of: BFO:0000050 GO:0045202 ! part of synapse
relationship: BFO:0000050 GO:0045202 ! part of synapse
creation_date: 2011-06-07T11:22:09Z

[Term]
id: GO:0097084
name: vascular associated smooth muscle cell development
namespace: biological_process
def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
synonym: "vascular smooth muscle cell development" EXACT []
is_a: GO:0055001 ! muscle cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell
relationship: BFO:0000050 GO:0035886 ! part of vascular associated smooth muscle cell differentiation
relationship: RO:0002296 CL:0000359 ! results in development of vascular associated smooth muscle cell
creation_date: 2011-06-20T04:03:08Z

[Term]
id: GO:0097094
name: craniofacial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0009198 ! results in morphogenesis of craniofacial suture
relationship: BFO:0000050 GO:0060349 ! part of bone morphogenesis
relationship: BFO:0000050 GO:1904888 ! part of cranial skeletal system development
relationship: RO:0002298 UBERON:0009198 ! results in morphogenesis of craniofacial suture
creation_date: 2011-07-05T02:51:54Z

[Term]
id: GO:0097096
name: facial suture morphogenesis
namespace: biological_process
def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system]
is_a: GO:0097094 ! craniofacial suture morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0009199 ! results in morphogenesis of facial suture
relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata <vertebrates>
relationship: RO:0002298 UBERON:0009199 ! results in morphogenesis of facial suture
creation_date: 2011-07-05T03:06:27Z

[Term]
id: GO:0097104
name: postsynaptic membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692]
subset: goslim_synapse
synonym: "post-synaptic membrane assembly" EXACT []
is_a: GO:0001941 ! postsynaptic membrane organization
is_a: GO:0071709 ! membrane assembly
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002588 GO:0045211 ! results in assembly of postsynaptic membrane
relationship: BFO:0000050 GO:0099068 ! part of postsynapse assembly
relationship: RO:0002588 GO:0045211 ! results in assembly of postsynaptic membrane
creation_date: 2011-07-27T01:26:49Z

[Term]
id: GO:0097120
name: receptor localization to synapse
namespace: biological_process
def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273]
synonym: "receptor localisation to synapse" EXACT []
is_a: GO:0031503 ! protein-containing complex localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0002339 GO:0045202 ! has target end location synapse
intersection_of: RO:0004009 GO:0098802 ! has primary input plasma membrane signaling receptor complex
relationship: RO:0002339 GO:0045202 ! has target end location synapse
relationship: RO:0004009 GO:0098802 ! has primary input plasma membrane signaling receptor complex
creation_date: 2011-07-31T09:20:30Z

[Term]
id: GO:0097152
name: mesenchymal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833]
synonym: "mesenchymal cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell
relationship: BFO:0000066 CL:0008019 ! occurs in mesenchymal cell
creation_date: 2011-09-06T02:31:59Z

[Term]
id: GO:0097154
name: GABAergic neuron differentiation
namespace: biological_process
def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000617 ! results in acquisition of features of GABAergic neuron
relationship: RO:0002315 CL:0000617 ! results in acquisition of features of GABAergic neuron
creation_date: 2011-09-14T09:39:11Z

[Term]
id: GO:0097164
name: ammonium ion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018]
synonym: "ammonium ion metabolism" EXACT []
synonym: "ammonium metabolic process" RELATED []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:28938 ! has primary input or output ammonium
relationship: RO:0004007 CHEBI:28938 ! has primary input or output ammonium
created_by: pr
creation_date: 2011-09-28T04:21:30Z

[Term]
id: GO:0097176
name: epoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179]
synonym: "epoxide metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
created_by: pr
creation_date: 2011-10-10T11:29:49Z

[Term]
id: GO:0097177
name: mitochondrial ribosome binding
namespace: molecular_function
def: "Binding to a mitochondrial ribosome." [GOC:ans, PMID:20739282]
is_a: GO:0043022 ! ribosome binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0005761 ! has primary input mitochondrial ribosome
relationship: RO:0004009 GO:0005761 ! has primary input mitochondrial ribosome
creation_date: 2011-10-11T03:03:03Z

[Term]
id: GO:0097190
name: apoptotic signaling pathway
namespace: biological_process
def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
synonym: "apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "induction of apoptosis by extracellular signals" EXACT []
xref: Reactome:R-HSA-193681 "Ceramide signalling"
xref: Reactome:R-HSA-204998 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:R-HSA-75157 "FasL/ CD95L signaling"
is_a: GO:0007165 ! signal transduction
relationship: BFO:0000050 GO:0006915 ! part of apoptotic process
creation_date: 2011-11-23T09:30:23Z

[Term]
id: GO:0097194
name: execution phase of apoptosis
namespace: biological_process
def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595]
synonym: "apoptosis" NARROW []
synonym: "execution phase of apoptotic process" EXACT []
xref: Reactome:R-HSA-75153 "Apoptotic execution phase"
is_a: GO:0009987 ! cellular process
relationship: BFO:0000050 GO:0006915 ! part of apoptotic process
relationship: BFO:0000051 GO:0032060 ! has part bleb assembly
creation_date: 2011-11-23T09:45:24Z

[Term]
id: GO:0097212
name: lysosomal membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854]
synonym: "lysosomal membrane organisation" EXACT [GOC:mah]
synonym: "lysosome membrane organization" EXACT []
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0005765 ! results in organization of lysosomal membrane
relationship: BFO:0000050 GO:0007040 ! part of lysosome organization
relationship: RO:0002592 GO:0005765 ! results in organization of lysosomal membrane
creation_date: 2012-01-12T10:16:15Z

[Term]
id: GO:0097252
name: oligodendrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520]
synonym: "oligodendrocyte apoptosis" NARROW []
is_a: GO:0034349 ! glial cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000128 ! occurs in oligodendrocyte
relationship: BFO:0000066 CL:0000128 ! occurs in oligodendrocyte
creation_date: 2012-03-05T10:51:15Z

[Term]
id: GO:0097355
name: protein localization to heterochromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah]
synonym: "protein localisation to heterochromatin" EXACT [GOC:mah]
is_a: GO:0071168 ! protein localization to chromatin
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0000792 ! has target end location heterochromatin
relationship: RO:0002339 GO:0000792 ! has target end location heterochromatin
creation_date: 2012-07-03T03:19:07Z

[Term]
id: GO:0097367
name: carbohydrate derivative binding
namespace: molecular_function
def: "Binding to a carbohydrate derivative." [GOC:pr]
subset: goslim_agr
subset: goslim_mouse
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
created_by: pr
creation_date: 2012-08-02T13:03:39Z

[Term]
id: GO:0097386
name: glial cell projection
namespace: cellular_component
def: "A prolongation or process extending from a glial cell." [GOC:mc]
synonym: "glial process" RELATED []
synonym: "glial projection" RELATED []
is_a: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: BFO:0000050 CL:0000125 ! part of glial cell
relationship: BFO:0000050 CL:0000125 ! part of glial cell
creation_date: 2012-10-22T13:55:54Z

[Term]
id: GO:0097402
name: neuroblast migration
namespace: biological_process
def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000031 ! results in movement of neuroblast (sensu Vertebrata)
relationship: RO:0002565 CL:0000031 ! results in movement of neuroblast (sensu Vertebrata)
creation_date: 2012-10-29T08:24:37Z

[Term]
id: GO:0097427
name: microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973]
synonym: "microtubule fascicle" EXACT []
xref: NIF_Subcellular:sao1872343973
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton
relationship: BFO:0000051 GO:0005874 ! has part microtubule
creation_date: 2012-11-07T15:01:27Z

[Term]
id: GO:0097435
name: supramolecular fiber organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]
synonym: "extracellular fibril organisation" NARROW []
synonym: "extracellular fibril organization" NARROW []
synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah]
synonym: "fibril organisation" RELATED []
synonym: "fibril organization" RELATED []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber
relationship: RO:0002592 GO:0099512 ! results in organization of supramolecular fiber
creation_date: 2012-11-27T15:46:25Z

[Term]
id: GO:0097447
name: dendritic tree
namespace: cellular_component
def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]
xref: NIF_Subcellular:sao172297168
is_a: GO:0043005 ! neuron projection
relationship: BFO:0000050 GO:0036477 ! part of somatodendritic compartment
relationship: BFO:0000051 GO:0030425 ! has part dendrite
creation_date: 2012-12-17T12:31:49Z

[Term]
id: GO:0097449
name: astrocyte projection
namespace: cellular_component
def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580]
synonym: "astrocyte process" EXACT []
synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894]
synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993]
xref: NIF_Subcellular:sao1630537580
is_a: GO:0097386 ! glial cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: BFO:0000050 CL:0000127 ! part of astrocyte
relationship: BFO:0000050 CL:0000127 ! part of astrocyte
creation_date: 2012-12-17T13:29:55Z

[Term]
id: GO:0097454
name: Schwann cell microvillus
namespace: cellular_component
def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042]
xref: NIF_Subcellular:sao1890444066
is_a: GO:0005902 ! microvillus
is_a: GO:0097386 ! glial cell projection
intersection_of: GO:0005902 ! microvillus
intersection_of: BFO:0000050 CL:0002573 ! part of Schwann cell
relationship: BFO:0000050 CL:0002573 ! part of Schwann cell
creation_date: 2012-12-19T13:01:02Z

[Term]
id: GO:0097473
name: retinal rod cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487]
synonym: "rod photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000604 ! occurs in retinal rod cell
relationship: BFO:0000066 CL:0000604 ! occurs in retinal rod cell
creation_date: 2013-03-21T09:44:45Z

[Term]
id: GO:0097474
name: retinal cone cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc]
synonym: "cone photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000573 ! occurs in retinal cone cell
relationship: BFO:0000066 CL:0000573 ! occurs in retinal cone cell
creation_date: 2013-03-21T09:46:22Z

[Term]
id: GO:0097475
name: motor neuron migration
namespace: biological_process
def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000100 ! results in movement of motor neuron
relationship: RO:0002565 CL:0000100 ! results in movement of motor neuron
creation_date: 2013-04-23T13:00:46Z

[Term]
id: GO:0097476
name: spinal cord motor neuron migration
namespace: biological_process
def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475]
is_a: GO:0097475 ! motor neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0011001 ! results in movement of spinal cord motor neuron
relationship: RO:0002565 CL:0011001 ! results in movement of spinal cord motor neuron
creation_date: 2013-04-23T13:03:46Z

[Term]
id: GO:0097511
name: dendritic cell dendrite
namespace: cellular_component
def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351]
is_a: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: BFO:0000050 CL:0000451 ! part of dendritic cell
relationship: BFO:0000050 CL:0000451 ! part of dendritic cell
creation_date: 2013-10-16T13:02:25Z

[Term]
id: GO:0097512
name: cardiac myofibril
namespace: cellular_component
def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol]
is_a: GO:0030016 ! myofibril
intersection_of: GO:0030016 ! myofibril
intersection_of: BFO:0000050 CL:0000746 ! part of cardiac muscle cell
relationship: BFO:0000050 CL:0000746 ! part of cardiac muscle cell
creation_date: 2013-10-16T13:04:58Z

[Term]
id: GO:0097529
name: myeloid leukocyte migration
namespace: biological_process
def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461]
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000766 ! results in movement of myeloid leukocyte
relationship: RO:0002565 CL:0000766 ! results in movement of myeloid leukocyte
creation_date: 2013-11-11T13:59:43Z

[Term]
id: GO:0097530
name: granulocyte migration
namespace: biological_process
def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336]
is_a: GO:0097529 ! myeloid leukocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000094 ! results in movement of granulocyte
relationship: RO:0002565 CL:0000094 ! results in movement of granulocyte
creation_date: 2013-11-11T14:00:44Z

[Term]
id: GO:0097534
name: lymphoid lineage cell migration
namespace: biological_process
def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843]
synonym: "lymphoid lineage restricted progenitor cell migration" EXACT []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000838 ! results in movement of lymphoid lineage restricted progenitor cell
relationship: RO:0002565 CL:0000838 ! results in movement of lymphoid lineage restricted progenitor cell
creation_date: 2013-11-28T10:47:15Z

[Term]
id: GO:0097576
name: vacuole fusion
namespace: biological_process
def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048284 ! organelle fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0012008 GO:0005773 ! results in fusion of vacuole
relationship: RO:0012008 GO:0005773 ! results in fusion of vacuole
creation_date: 2014-02-28T09:49:31Z

[Term]
id: GO:0097708
name: intracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the intracellular region." [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle
intersection_of: GO:0031982 ! vesicle
intersection_of: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure
creation_date: 2016-03-29T17:39:45Z

[Term]
id: GO:0097711
name: ciliary basal body-plasma membrane docking
namespace: biological_process
def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235]
comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.
synonym: "anchoring of the basal body to the plasma membrane" RELATED []
synonym: "ciliary basal body docking" EXACT []
xref: Reactome:R-HSA-5620912 "Anchoring of the basal body to the plasma membrane"
is_a: GO:0140056 ! organelle localization by membrane tethering
relationship: BFO:0000050 GO:0060271 ! part of cilium assembly
creation_date: 2016-08-05T16:12:33Z

[Term]
id: GO:0097712
name: vesicle targeting, trans-Golgi to periciliary membrane compartment
namespace: biological_process
def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645]
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: BFO:0000050 GO:0060271 ! part of cilium assembly
creation_date: 2016-08-05T16:16:28Z

[Term]
id: GO:0097734
name: extracellular exosome biogenesis
namespace: biological_process
def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495]
synonym: "exosome assembly or secretion" EXACT []
synonym: "exosome biogenesis" EXACT []
synonym: "exosome production" EXACT []
synonym: "ILV assembly" RELATED []
synonym: "intraluminal vesicle assembly" RELATED []
is_a: GO:0140112 ! extracellular vesicle biogenesis
creation_date: 2016-10-03T14:35:25Z

[Term]
id: GO:0098523
name: neuromuscular junction of myotube
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes.
is_a: GO:0031594 ! neuromuscular junction
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002131 CL:0000100 ! overlaps motor neuron
intersection_of: RO:0002131 CL:0002372 ! overlaps myotube
relationship: RO:0002131 CL:0002372 ! overlaps myotube
creation_date: 2013-10-14T12:05:12Z

[Term]
id: GO:0098528
name: skeletal muscle fiber differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos]
is_a: GO:0014902 ! myotube differentiation
is_a: GO:0035914 ! skeletal muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber
relationship: RO:0002315 CL:0008002 ! results in acquisition of features of skeletal muscle fiber
creation_date: 2013-10-15T14:00:34Z

[Term]
id: GO:0098542
name: defense response to other organism
namespace: biological_process
alt_id: GO:0009814
def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "defence response incompatible interaction" NARROW []
synonym: "defence response to pathogen, incompatible interaction" NARROW []
synonym: "defense response, incompatible interaction" NARROW []
synonym: "resistance response to pathogen" NARROW []
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism
created_by: dos
creation_date: 2013-11-11T12:59:11Z

[Term]
id: GO:0098544
name: maintenance of protein complex location
namespace: biological_process
def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos]
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0051235 ! maintenance of location
intersection_of: GO:0051235 ! maintenance of location
intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex
creation_date: 2013-11-15T18:20:16Z

[Term]
id: GO:0098545
name: maintenance of protein complex location in cytoplasm
namespace: biological_process
def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos]
is_a: GO:0051651 ! maintenance of location in cell
is_a: GO:0098544 ! maintenance of protein complex location
intersection_of: GO:0098544 ! maintenance of protein complex location
intersection_of: BFO:0000066 GO:0005737 ! occurs in cytoplasm
intersection_of: RO:0004009 GO:0032991 ! has primary input protein-containing complex
relationship: BFO:0000066 GO:0005737 ! occurs in cytoplasm
creation_date: 2013-11-15T20:49:15Z

[Term]
id: GO:0098588
name: bounding membrane of organelle
namespace: cellular_component
def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]
comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0043226 ! bounding layer of organelle
relationship: RO:0002007 GO:0043226 ! bounding layer of organelle
creation_date: 2014-02-26T13:41:31Z

[Term]
id: GO:0098590
name: plasma membrane region
namespace: cellular_component
def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
subset: gocheck_do_not_annotate
synonym: "region of plasma membrane" EXACT []
is_a: GO:0016020 ! membrane
intersection_of: GO:0016020 ! membrane
intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane
relationship: BFO:0000050 GO:0005886 ! part of plasma membrane
created_by: dos
creation_date: 2014-03-06T11:55:32Z

[Term]
id: GO:0098609
name: cell-cell adhesion
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos]
synonym: "single organismal cell-cell adhesion" RELATED []
is_a: GO:0007155 ! cell adhesion
creation_date: 2014-04-16T13:40:03Z

[Term]
id: GO:0098631
name: cell adhesion mediator activity
namespace: molecular_function
def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "cell adhesion molecule" EXACT []
synonym: "protein binding involved in cell adhesion" EXACT []
is_a: GO:0050839 ! cell adhesion molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: BFO:0000050 GO:0007155 ! part of cell adhesion
relationship: BFO:0000050 GO:0007155 ! part of cell adhesion

[Term]
id: GO:0098632
name: cell-cell adhesion mediator activity
namespace: molecular_function
def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]
synonym: "cell-cell adhesion molecule" EXACT []
synonym: "protein binding involved in cell-cell adhesion" EXACT []
is_a: GO:0098631 ! cell adhesion mediator activity
intersection_of: GO:0005515 ! protein binding
intersection_of: BFO:0000050 GO:0098609 ! part of cell-cell adhesion
relationship: BFO:0000050 GO:0098609 ! part of cell-cell adhesion

[Term]
id: GO:0098633
name: collagen fibril binding
namespace: molecular_function
def: "Binding to a collagen fibril." [GOC:dos, PMID:21421911]
is_a: GO:0050840 ! extracellular matrix binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0098643 ! has primary input fibrillar collagen
relationship: RO:0004009 GO:0098643 ! has primary input fibrillar collagen

[Term]
id: GO:0098635
name: protein complex involved in cell-cell adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0098636 ! protein complex involved in cell adhesion
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002216 GO:0098609 ! capable of part of cell-cell adhesion
relationship: RO:0002216 GO:0098609 ! capable of part of cell-cell adhesion

[Term]
id: GO:0098636
name: protein complex involved in cell adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos]
synonym: "cell adhesion complex" RELATED []
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002216 GO:0007155 ! capable of part of cell adhesion
relationship: RO:0002216 GO:0007155 ! capable of part of cell adhesion

[Term]
id: GO:0098641
name: cadherin binding involved in cell-cell adhesion
namespace: molecular_function
def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0045296 ! cadherin binding
is_a: GO:0098632 ! cell-cell adhesion mediator activity
intersection_of: GO:0045296 ! cadherin binding
intersection_of: BFO:0000050 GO:0098609 ! part of cell-cell adhesion

[Term]
id: GO:0098642
name: network-forming collagen trimer
namespace: cellular_component
def: "A collagen trimer that forms networks." [PMID:21421911]
is_a: GO:0005581 ! collagen trimer
intersection_of: GO:0005581 ! collagen trimer
intersection_of: BFO:0000050 GO:0098645 ! part of collagen network
relationship: BFO:0000050 GO:0098645 ! part of collagen network

[Term]
id: GO:0098643
name: fibrillar collagen
namespace: cellular_component
def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:20386646, PMID:21421911, PMID:29853175]
synonym: "banded collagen fibril" EXACT []
is_a: GO:0098644 ! complex of collagen trimers
relationship: BFO:0000050 GO:0140152 ! part of collagenous component of interstitial matrix

[Term]
id: GO:0098644
name: complex of collagen trimers
namespace: cellular_component
def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos]
synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541]
synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911]
is_a: GO:0099080 ! supramolecular complex
relationship: BFO:0000050 GO:0031012 ! part of extracellular matrix
relationship: BFO:0000051 GO:0005581 ! has part collagen trimer

[Term]
id: GO:0098645
name: collagen network
namespace: cellular_component
def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers

[Term]
id: GO:0098657
name: import into cell
namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005737 ! has target end location cytoplasm
intersection_of: RO:0004009 CHEBI:24431 ! has primary input chemical entity
relationship: RO:0002338 GO:0005576 ! has target start location extracellular region
relationship: RO:0002339 GO:0005737 ! has target end location cytoplasm
relationship: RO:0004009 CHEBI:24431 ! has primary input chemical entity

[Term]
id: GO:0098664
name: G protein-coupled serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "G-protein coupled serotonin receptor signaling pathway" EXACT []
is_a: GO:0007186 ! G protein-coupled receptor signaling pathway
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002224 GO:0004993 ! starts with G protein-coupled serotonin receptor activity
relationship: RO:0002224 GO:0004993 ! starts with G protein-coupled serotonin receptor activity
creation_date: 2016-12-21T12:07:58Z

[Term]
id: GO:0098666
name: G protein-coupled serotonin receptor complex
namespace: cellular_component
def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie]
synonym: "G-protein coupled serotonin receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0004993 ! capable of G protein-coupled serotonin receptor activity
relationship: RO:0002215 GO:0004993 ! capable of G protein-coupled serotonin receptor activity
relationship: RO:0002216 GO:0098664 ! capable of part of G protein-coupled serotonin receptor signaling pathway
creation_date: 2016-12-21T12:28:12Z

[Term]
id: GO:0098690
name: glycinergic synapse
namespace: cellular_component
def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002215 GO:0060012 ! capable of synaptic transmission, glycinergic
relationship: RO:0002215 GO:0060012 ! capable of synaptic transmission, glycinergic
creation_date: 2017-03-07T14:50:33Z

[Term]
id: GO:0098691
name: dopaminergic synapse
namespace: cellular_component
def: "A synapse that uses dopamine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002215 GO:0001963 ! capable of synaptic transmission, dopaminergic
relationship: RO:0002215 GO:0001963 ! capable of synaptic transmission, dopaminergic
creation_date: 2017-03-07T14:51:52Z

[Term]
id: GO:0098704
name: carbohydrate import across plasma membrane
namespace: biological_process
def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "carbohydrate import into cell" EXACT []
is_a: GO:0034219 ! carbohydrate transmembrane transport
is_a: GO:0098739 ! import across plasma membrane
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
creation_date: 2012-05-31T02:45:02Z

[Term]
id: GO:0098712
name: L-glutamate import across plasma membrane
namespace: biological_process
def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "L-glutamate import into cell" EXACT []
synonym: "L-glutamate(1-) import across plasma membrane" BROAD []
synonym: "L-glutamate(1-) import into cell" EXACT []
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
creation_date: 2013-06-12T12:32:47Z

[Term]
id: GO:0098722
name: asymmetric stem cell division
namespace: biological_process
def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0017145 ! stem cell division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell

[Term]
id: GO:0098723
name: skeletal muscle myofibril
namespace: cellular_component
def: "A myofibril of a skeletal muscle fiber." [GOC:dos]
is_a: GO:0030016 ! myofibril
intersection_of: GO:0030016 ! myofibril
intersection_of: BFO:0000050 CL:0008002 ! part of skeletal muscle fiber
relationship: BFO:0000050 CL:0008002 ! part of skeletal muscle fiber
relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata <vertebrates>

[Term]
id: GO:0098728
name: germline stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos]
is_a: GO:0042078 ! germ-line stem cell division
is_a: GO:0098722 ! asymmetric stem cell division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: RO:0004009 CL:0000014 ! has primary input germ line stem cell

[Term]
id: GO:0098739
name: import across plasma membrane
namespace: biological_process
def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0098657 ! import into cell
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
relationship: RO:0002339 GO:0005829 ! has target end location cytosol
relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane

[Term]
id: GO:0098749
name: cerebellar neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
is_a: GO:0021954 ! central nervous system neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:1001611 ! results in development of cerebellar neuron
relationship: BFO:0000050 GO:0021549 ! part of cerebellum development
relationship: RO:0002296 CL:1001611 ! results in development of cerebellar neuron

[Term]
id: GO:0098751
name: bone cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.
subset: gocheck_do_not_annotate
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: RO:0002296 CL:0001035 ! results in development of bone cell
relationship: BFO:0000050 GO:0060348 ! part of bone development
relationship: RO:0002296 CL:0001035 ! results in development of bone cell

[Term]
id: GO:0098762
name: meiotic cell cycle phase
namespace: biological_process
def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos]
comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0022403 ! cell cycle phase
intersection_of: GO:0022403 ! cell cycle phase
intersection_of: RO:0002092 GO:0051321 ! happens during meiotic cell cycle
relationship: RO:0002092 GO:0051321 ! happens during meiotic cell cycle

[Term]
id: GO:0098764
name: meiosis I cell cycle phase
namespace: biological_process
def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos]
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).
subset: gocheck_do_not_annotate
is_a: GO:0098762 ! meiotic cell cycle phase

[Term]
id: GO:0098773
name: skin epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos]
is_a: GO:0008544 ! epidermis development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001003 ! results in development of skin epidermis
relationship: BFO:0000050 GO:0043588 ! part of skin development
relationship: RO:0002296 UBERON:0001003 ! results in development of skin epidermis

[Term]
id: GO:0098793
name: presynapse
namespace: cellular_component
def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos]
subset: goslim_synapse
synonym: "presynaptic terminal" EXACT []
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000540 ! part of neuron
relationship: BFO:0000050 GO:0045202 ! part of synapse
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa

[Term]
id: GO:0098794
name: postsynapse
namespace: cellular_component
def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos]
subset: goslim_synapse
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell
relationship: BFO:0000050 GO:0045202 ! part of synapse

[Term]
id: GO:0098796
name: membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of a membrane." [GOC:dos]
subset: goslim_metagenomics
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: BFO:0000050 GO:0016020 ! part of membrane
relationship: BFO:0000050 GO:0016020 ! part of membrane

[Term]
id: GO:0098797
name: plasma membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane
relationship: BFO:0000050 GO:0005886 ! part of plasma membrane

[Term]
id: GO:0098798
name: mitochondrial protein-containing complex
namespace: cellular_component
def: "A protein complex that is part of a mitochondrion." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "mitochondrial protein complex" RELATED []
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion
relationship: BFO:0000050 GO:0005739 ! part of mitochondrion

[Term]
id: GO:0098799
name: outer mitochondrial membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:0098798 ! mitochondrial protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: BFO:0000050 GO:0005741 ! part of mitochondrial outer membrane
relationship: BFO:0000050 GO:0005741 ! part of mitochondrial outer membrane

[Term]
id: GO:0098802
name: plasma membrane signaling receptor complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
is_a: GO:0043235 ! receptor complex
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane
intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity

[Term]
id: GO:0098813
name: nuclear chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos]
is_a: GO:0007059 ! chromosome segregation

[Term]
id: GO:0098840
name: protein transport along microtubule
namespace: biological_process
def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607]
synonym: "microtubule-based protein transport" BROAD []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0099118 ! microtubule-based protein transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0098852
name: lytic vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]
is_a: GO:0005774 ! vacuolar membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0000323 ! bounding layer of lytic vacuole
relationship: RO:0002007 GO:0000323 ! bounding layer of lytic vacuole

[Term]
id: GO:0098858
name: actin-based cell projection
namespace: cellular_component
def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: BFO:0000051 GO:0005884 ! has part actin filament

[Term]
id: GO:0098862
name: cluster of actin-based cell projections
namespace: cellular_component
def: "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos]
is_a: GO:0110165 ! cellular anatomical structure
relationship: BFO:0000050 CL:0000000 ! part of cell
relationship: BFO:0000051 GO:0098858 ! has part actin-based cell projection

[Term]
id: GO:0098867
name: intramembranous bone growth
namespace: biological_process
def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686]
is_a: GO:0098868 ! bone growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone
relationship: RO:0002343 UBERON:0002514 ! results in growth of intramembranous bone

[Term]
id: GO:0098868
name: bone growth
namespace: biological_process
def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos]
is_a: GO:0035265 ! organ growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: RO:0002343 UBERON:0001474 ! results in growth of bone element
relationship: BFO:0000050 GO:0060348 ! part of bone development
relationship: RO:0002343 UBERON:0001474 ! results in growth of bone element

[Term]
id: GO:0098871
name: postsynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton
intersection_of: GO:0015629 ! actin cytoskeleton
intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse

[Term]
id: GO:0098876
name: vesicle-mediated transport to the plasma membrane
namespace: biological_process
def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0051668 ! localization within membrane
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
intersection_of: RO:0002608 GO:0031982 ! process has causal agent vesicle
relationship: RO:0002230 GO:0006887 ! ends with exocytosis
relationship: RO:0002339 GO:0005886 ! has target end location plasma membrane

[Term]
id: GO:0098877
name: neurotransmitter receptor transport to plasma membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane
is_a: GO:0099637 ! neurotransmitter receptor transport
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0015031 ! protein transport
intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex

[Term]
id: GO:0098878
name: neurotransmitter receptor complex
namespace: cellular_component
def: "Any protein complex that is capable of functioning as a neurotransmitter receptor." [GOC:dos]
is_a: GO:0098802 ! plasma membrane signaling receptor complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0030594 ! capable of neurotransmitter receptor activity
relationship: RO:0002215 GO:0030594 ! capable of neurotransmitter receptor activity

[Term]
id: GO:0098883
name: synapse pruning
namespace: biological_process
def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]
subset: goslim_synapse
synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190]
synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
is_a: GO:0050808 ! synapse organization
is_a: GO:0150146 ! cell junction disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0045202 ! results in disassembly of synapse
relationship: RO:0002590 GO:0045202 ! results in disassembly of synapse

[Term]
id: GO:0098900
name: regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term.
is_a: GO:0042391 ! regulation of membrane potential
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0001508 ! regulates action potential
relationship: RO:0002211 GO:0001508 ! regulates action potential

[Term]
id: GO:0098901
name: regulation of cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential
relationship: RO:0002211 GO:0086001 ! regulates cardiac muscle cell action potential

[Term]
id: GO:0098904
name: regulation of AV node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "regulation of AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0086016 ! regulates AV node cell action potential
relationship: RO:0002211 GO:0086016 ! regulates AV node cell action potential
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0098906
name: regulation of Purkinje myocyte action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential
relationship: RO:0002211 GO:0086017 ! regulates Purkinje myocyte action potential
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0098907
name: regulation of SA node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0086015 ! regulates SA node cell action potential
relationship: RO:0002211 GO:0086015 ! regulates SA node cell action potential
creation_date: 2011-11-10T08:50:15Z

[Term]
id: GO:0098908
name: regulation of neuronal action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051969 ! regulation of transmission of nerve impulse
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0019228 ! regulates neuronal action potential
relationship: RO:0002211 GO:0019228 ! regulates neuronal action potential

[Term]
id: GO:0098916
name: anterograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002231 GO:0098793 ! has start location presynapse
intersection_of: RO:0002232 GO:0098794 ! has end location postsynapse
relationship: RO:0002231 GO:0098793 ! has start location presynapse
relationship: RO:0002232 GO:0098794 ! has end location postsynapse

[Term]
id: GO:0098917
name: retrograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse
intersection_of: RO:0002232 GO:0098793 ! has end location presynapse
relationship: RO:0002231 GO:0098794 ! has start location postsynapse
relationship: RO:0002232 GO:0098793 ! has end location presynapse

[Term]
id: GO:0098920
name: retrograde trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099541 ! trans-synaptic signaling by lipid
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse
intersection_of: RO:0002232 GO:0098793 ! has end location presynapse
intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid

[Term]
id: GO:0098926
name: postsynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse
relationship: BFO:0000050 GO:0099536 ! part of synaptic signaling
relationship: RO:0002231 GO:0098794 ! has start location postsynapse

[Term]
id: GO:0098928
name: presynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: RO:0002231 GO:0098793 ! has start location presynapse
relationship: RO:0002231 GO:0098793 ! has start location presynapse

[Term]
id: GO:0098930
name: axonal transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" EXACT []
synonym: "axoplasmic transport" EXACT []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0008088 ! axo-dendritic transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0030424 ! occurs in axon
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:0030424 ! occurs in axon

[Term]
id: GO:0098934
name: retrograde dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
relationship: RO:0002338 GO:0098793 ! has target start location presynapse

[Term]
id: GO:0098935
name: dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194]
subset: goslim_synapse
synonym: "dendrite cargo transport" EXACT []
is_a: GO:0008088 ! axo-dendritic transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0030425 ! occurs in dendrite
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:0030425 ! occurs in dendrite

[Term]
id: GO:0098937
name: anterograde dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194]
subset: goslim_synapse
is_a: GO:0098935 ! dendritic transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
relationship: RO:0002339 GO:0098794 ! has target end location postsynapse

[Term]
id: GO:0098939
name: dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai]
subset: goslim_synapse
is_a: GO:0047497 ! mitochondrion transport along microtubule
is_a: GO:0098935 ! dendritic transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion
relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm

[Term]
id: GO:0098957
name: anterograde axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon transport of mitochondria" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0019896 ! axonal transport of mitochondrion
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0098958
name: retrograde axonal transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "retrograde axon transport of mitochondria" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0019896 ! axonal transport of mitochondrion
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0098959
name: retrograde dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "retrograde dendrite transport of mitochondria" EXACT []
is_a: GO:0098939 ! dendritic transport of mitochondrion
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002338 GO:0098794 ! has target start location postsynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion
relationship: RO:0002338 GO:0098794 ! has target start location postsynapse

[Term]
id: GO:0098960
name: postsynaptic neurotransmitter receptor activity
namespace: molecular_function
def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane during synaptic transmission." [GOC:dos, GOC:signaling]
synonym: "neurotransmitter receptor activity involved in chemical synaptic transmission" EXACT []
is_a: GO:0030594 ! neurotransmitter receptor activity
intersection_of: GO:0030594 ! neurotransmitter receptor activity
intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission
relationship: BFO:0000050 GO:0099565 ! part of chemical synaptic transmission, postsynaptic
relationship: BFO:0000066 GO:0045211 ! occurs in postsynaptic membrane

[Term]
id: GO:0098961
name: dendritic transport of ribonucleoprotein complex
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos]
subset: goslim_synapse
synonym: "dendritic transport of RNP complex" EXACT []
is_a: GO:0031503 ! protein-containing complex localization
is_a: GO:0098935 ! dendritic transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex
relationship: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
relationship: RO:0004009 GO:1990904 ! has primary input ribonucleoprotein complex

[Term]
id: GO:0098967
name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane
namespace: biological_process
def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082]
subset: goslim_synapse
is_a: GO:0006887 ! exocytosis
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
intersection_of: GO:0006887 ! exocytosis
intersection_of: BFO:0000050 GO:0098969 ! part of neurotransmitter receptor transport to postsynaptic membrane
relationship: BFO:0000050 GO:0098969 ! part of neurotransmitter receptor transport to postsynaptic membrane

[Term]
id: GO:0098969
name: neurotransmitter receptor transport to postsynaptic membrane
namespace: biological_process
def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane
is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels
is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane
intersection_of: GO:0015031 ! protein transport
intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane
intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex

[Term]
id: GO:0098971
name: anterograde dendritic transport of neurotransmitter receptor complex
namespace: biological_process
def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0098937 ! anterograde dendritic transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex
relationship: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex

[Term]
id: GO:0098972
name: anterograde dendritic transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098937 ! anterograde dendritic transport
is_a: GO:0098939 ! dendritic transport of mitochondrion
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0032839 ! occurs in dendrite cytoplasm
intersection_of: RO:0002339 GO:0098794 ! has target end location postsynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion

[Term]
id: GO:0098974
name: postsynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0099188 ! postsynaptic cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton
relationship: RO:0002592 GO:0098871 ! results in organization of postsynaptic actin cytoskeleton

[Term]
id: GO:0098975
name: postsynapse of neuromuscular junction
namespace: cellular_component
def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502]
is_a: GO:0098794 ! postsynapse
intersection_of: GO:0098794 ! postsynapse
intersection_of: BFO:0000050 CL:0000187 ! part of muscle cell
intersection_of: BFO:0000050 GO:0031594 ! part of neuromuscular junction
relationship: BFO:0000050 CL:0000187 ! part of muscle cell
relationship: BFO:0000050 GO:0031594 ! part of neuromuscular junction

[Term]
id: GO:0098978
name: glutamatergic synapse
namespace: cellular_component
def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002215 GO:0035249 ! capable of synaptic transmission, glutamatergic
relationship: RO:0002215 GO:0035249 ! capable of synaptic transmission, glutamatergic

[Term]
id: GO:0098981
name: cholinergic synapse
namespace: cellular_component
def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002215 GO:0007271 ! capable of synaptic transmission, cholinergic
relationship: RO:0002215 GO:0007271 ! capable of synaptic transmission, cholinergic

[Term]
id: GO:0098982
name: GABA-ergic synapse
namespace: cellular_component
def: "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: RO:0002215 GO:0051932 ! capable of synaptic transmission, GABAergic
relationship: RO:0002215 GO:0051932 ! capable of synaptic transmission, GABAergic

[Term]
id: GO:0098988
name: G protein-coupled glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [GOC:dos]
synonym: "G-protein coupled glutamate receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0008066 ! glutamate receptor activity
intersection_of: GO:0004930 ! G protein-coupled receptor activity
intersection_of: RO:0004009 CHEBI:14321 ! has primary input

[Term]
id: GO:0098992
name: neuronal dense core vesicle
namespace: cellular_component
def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]
subset: goslim_synapse
is_a: GO:0031045 ! dense core granule
intersection_of: GO:0031045 ! dense core granule
intersection_of: BFO:0000050 CL:0000540 ! part of neuron
relationship: BFO:0000050 CL:0000540 ! part of neuron
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa

[Term]
id: GO:0099003
name: vesicle-mediated transport in synapse
namespace: biological_process
def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0099012
name: neuronal dense core vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos]
subset: goslim_synapse
is_a: GO:0032127 ! dense core granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0098992 ! bounding layer of neuronal dense core vesicle
relationship: RO:0002007 GO:0098992 ! bounding layer of neuronal dense core vesicle

[Term]
id: GO:0099014
name: neuronal dense core vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos]
is_a: GO:0061109 ! dense core granule organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle
relationship: RO:0002592 GO:0098992 ! results in organization of neuronal dense core vesicle

[Term]
id: GO:0099054
name: presynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]
subset: goslim_synapse
synonym: "presynapse biogenesis" EXACT [GOC:mah]
synonym: "presynaptic terminal assembly" EXACT [PMID:24449494]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0099172 ! presynapse organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002588 GO:0098793 ! results in assembly of presynapse
relationship: BFO:0000050 GO:0007416 ! part of synapse assembly
relationship: RO:0002588 GO:0098793 ! results in assembly of presynapse

[Term]
id: GO:0099068
name: postsynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL]
synonym: "postsynapse biogenesis" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0099173 ! postsynapse organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002588 GO:0098794 ! results in assembly of postsynapse
relationship: BFO:0000050 GO:0007416 ! part of synapse assembly
relationship: RO:0002588 GO:0098794 ! results in assembly of postsynapse

[Term]
id: GO:0099072
name: regulation of postsynaptic membrane neurotransmitter receptor levels
namespace: biological_process
def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0099074
name: mitochondrion to lysosome vesicle-mediated transport
namespace: biological_process
def: "Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655]
synonym: "mitochondrion to lysosome transport" EXACT []
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: RO:0002338 GO:0005739 ! has target start location mitochondrion
intersection_of: RO:0002339 GO:0005764 ! has target end location lysosome
relationship: RO:0002339 GO:0005764 ! has target end location lysosome

[Term]
id: GO:0099075
name: mitochondrion-derived vesicle mediated transport
namespace: biological_process
def: "Vesicle-mediated transport of cargo from the mitochondrion by a mitochondrion-derived vesicle." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655, PMID:37131163]
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: RO:0002338 GO:0005739 ! has target start location mitochondrion
relationship: RO:0002338 GO:0005739 ! has target start location mitochondrion

[Term]
id: GO:0099080
name: supramolecular complex
namespace: cellular_component
def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]
subset: gocheck_do_not_annotate
is_a: GO:0110165 ! cellular anatomical structure

[Term]
id: GO:0099081
name: supramolecular polymer
namespace: cellular_component
def: "A polymeric supramolecular structure." [GOC:dos]
is_a: GO:0099080 ! supramolecular complex
intersection_of: GO:0099080 ! supramolecular complex
intersection_of: RO:0000053 PATO:0015006 ! bearer of polymeric
relationship: RO:0000053 PATO:0015006 ! bearer of polymeric

[Term]
id: GO:0099082
name: retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse
intersection_of: RO:0002232 GO:0098793 ! has end location presynapse
intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion

[Term]
id: GO:0099083
name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
intersection_of: RO:0002231 GO:0098794 ! has start location postsynapse
intersection_of: RO:0002232 GO:0098793 ! has end location presynapse
intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion

[Term]
id: GO:0099098
name: microtubule polymerization based movement
namespace: biological_process
def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194]
is_a: GO:0007018 ! microtubule-based movement
intersection_of: GO:0007018 ! microtubule-based movement
intersection_of: BFO:0000051 GO:0046785 ! has part microtubule polymerization
relationship: BFO:0000051 GO:0046785 ! has part microtubule polymerization

[Term]
id: GO:0099111
name: microtubule-based transport
namespace: biological_process
def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule
relationship: RO:0002608 GO:0005874 ! process has causal agent microtubule

[Term]
id: GO:0099112
name: microtubule polymerization based protein transport
namespace: biological_process
def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0099118 ! microtubule-based protein transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000051 GO:0046785 ! has part microtubule polymerization
intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000051 GO:0046785 ! has part microtubule polymerization

[Term]
id: GO:0099118
name: microtubule-based protein transport
namespace: biological_process
def: "A microtubule-based process that results in the transport of proteins." [GOC:vw]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0015031 ! protein transport
is_a: GO:0099111 ! microtubule-based transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002608 GO:0005874 ! process has causal agent microtubule
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0099123
name: somato-dendritic dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." [GOC:bf, GOC:PARL, PMID:21576241]
synonym: "somatodendritic dopamine release" EXACT [PMID:21576241]
synonym: "STD DA release" EXACT [PMID:21576241]
synonym: "STD dopamine release" EXACT [PMID:21576241]
is_a: GO:0014046 ! dopamine secretion
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0014046 ! dopamine secretion
intersection_of: BFO:0000066 GO:0036477 ! occurs in somatodendritic compartment
relationship: BFO:0000066 GO:0036477 ! occurs in somatodendritic compartment

[Term]
id: GO:0099124
name: axonal dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine from an axon." [GOC:bf, GOC:PARL, PMID:21576241]
synonym: "axonal DA release" EXACT [PMID:21576241]
synonym: "axonal dopamine release" EXACT [PMID:21576241]
is_a: GO:0014046 ! dopamine secretion
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0014046 ! dopamine secretion
intersection_of: BFO:0000066 GO:0030424 ! occurs in axon
relationship: BFO:0000066 GO:0030424 ! occurs in axon

[Term]
id: GO:0099140
name: presynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0099187 ! presynaptic cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton
relationship: RO:0002592 GO:0099143 ! results in organization of presynaptic actin cytoskeleton
creation_date: 2017-06-09T18:34:19Z

[Term]
id: GO:0099143
name: presynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099569 ! presynaptic cytoskeleton
intersection_of: GO:0015629 ! actin cytoskeleton
intersection_of: BFO:0000050 GO:0098793 ! part of presynapse
creation_date: 2017-06-09T18:36:19Z

[Term]
id: GO:0099145
name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos]
subset: goslim_synapse
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:1902683 ! regulation of receptor localization to synapse
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098967 ! regulates exocytic insertion of neurotransmitter receptor to postsynaptic membrane
relationship: RO:0002211 GO:0098967 ! regulates exocytic insertion of neurotransmitter receptor to postsynaptic membrane
creation_date: 2017-06-09T18:49:26Z

[Term]
id: GO:0099156
name: cell-cell signaling via exosome
namespace: biological_process
def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038]
synonym: "exosome mediated" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome
relationship: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome
creation_date: 2017-07-05T16:40:45Z

[Term]
id: GO:0099157
name: trans-synaptic signaling via exosome
namespace: biological_process
def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038]
subset: goslim_synapse
synonym: "exosome mediated transynaptic signalling" EXACT []
synonym: "trans-synaptic signalling via exosome" EXACT []
is_a: GO:0099156 ! cell-cell signaling via exosome
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002608 GO:0070062 ! process has causal agent extracellular exosome
creation_date: 2017-07-05T16:49:44Z

[Term]
id: GO:0099170
name: postsynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse
creation_date: 2017-09-11T17:09:17Z

[Term]
id: GO:0099171
name: presynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
creation_date: 2017-09-11T17:09:31Z

[Term]
id: GO:0099172
name: presynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "presynapse development" EXACT []
synonym: "presynapse morphogenesis" RELATED [GOC:BHF]
synonym: "presynapse organisation" EXACT []
synonym: "presynapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002592 GO:0098793 ! results in organization of presynapse
relationship: BFO:0000050 GO:0050808 ! part of synapse organization
relationship: RO:0002592 GO:0098793 ! results in organization of presynapse

[Term]
id: GO:0099173
name: postsynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynapse development" EXACT []
synonym: "postsynapse morphogenesis" RELATED [GOC:BHF]
synonym: "postsynapse organisation" EXACT []
synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002592 GO:0098794 ! results in organization of postsynapse
relationship: BFO:0000050 GO:0050808 ! part of synapse organization
relationship: RO:0002592 GO:0098794 ! results in organization of postsynapse

[Term]
id: GO:0099174
name: regulation of presynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of presynapse organisation" EXACT [GOC:mah]
synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of presynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099172 ! regulates presynapse organization
relationship: RO:0002211 GO:0099172 ! regulates presynapse organization

[Term]
id: GO:0099175
name: regulation of postsynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of postsynapse organisation" EXACT [GOC:mah]
synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of postsynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099173 ! regulates postsynapse organization
relationship: RO:0002211 GO:0099173 ! regulates postsynapse organization

[Term]
id: GO:0099177
name: regulation of trans-synaptic signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling
relationship: RO:0002211 GO:0099537 ! regulates trans-synaptic signaling

[Term]
id: GO:0099187
name: presynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos]
is_a: GO:0007010 ! cytoskeleton organization
intersection_of: GO:0009987 ! cellular process
intersection_of: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton
relationship: BFO:0000050 GO:0099172 ! part of presynapse organization
relationship: RO:0002592 GO:0099569 ! results in organization of presynaptic cytoskeleton
creation_date: 2017-12-20T15:05:34Z

[Term]
id: GO:0099188
name: postsynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007010 ! cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton
relationship: BFO:0000050 GO:0099173 ! part of postsynapse organization
relationship: RO:0002592 GO:0099571 ! results in organization of postsynaptic cytoskeleton
creation_date: 2017-12-20T15:06:57Z

[Term]
id: GO:0099500
name: vesicle fusion to plasma membrane
namespace: biological_process
def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0140029 ! exocytic process
intersection_of: GO:0061025 ! membrane fusion
intersection_of: BFO:0000050 GO:0006887 ! part of exocytosis
intersection_of: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane
intersection_of: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region
relationship: RO:0012008 GO:0098590 ! results in fusion of plasma membrane region

[Term]
id: GO:0099501
name: exocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030658 ! transport vesicle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: RO:0002007 GO:0070382 ! bounding layer of exocytic vesicle
relationship: RO:0002007 GO:0070382 ! bounding layer of exocytic vesicle

[Term]
id: GO:0099503
name: secretory vesicle
namespace: cellular_component
def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]
subset: goslim_drosophila
is_a: GO:0031410 ! cytoplasmic vesicle
intersection_of: GO:0031982 ! vesicle
intersection_of: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane
relationship: RO:0002215 GO:0099500 ! capable of vesicle fusion to plasma membrane

[Term]
id: GO:0099512
name: supramolecular fiber
namespace: cellular_component
def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]
synonym: "fibril" RELATED []
is_a: GO:0099081 ! supramolecular polymer
intersection_of: GO:0099080 ! supramolecular complex
intersection_of: RO:0000053 PATO:0002309 ! bearer of fiber shaped
intersection_of: RO:0000053 PATO:0015006 ! bearer of polymeric
relationship: RO:0000053 PATO:0002309 ! bearer of fiber shaped

[Term]
id: GO:0099513
name: polymeric cytoskeletal fiber
namespace: cellular_component
def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]
is_a: GO:0099512 ! supramolecular fiber
intersection_of: GO:0099512 ! supramolecular fiber
intersection_of: BFO:0000050 GO:0005856 ! part of cytoskeleton
intersection_of: RO:0000053 PATO:0015006 ! bearer of polymeric
relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton

[Term]
id: GO:0099515
name: actin filament-based transport
namespace: biological_process
def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0005884 ! results in transport along actin filament
relationship: RO:0002341 GO:0005884 ! results in transport along actin filament
creation_date: 2009-05-27T10:56:08Z

[Term]
id: GO:0099518
name: vesicle cytoskeletal trafficking
namespace: biological_process
def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]
synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl]
synonym: "vesicle cytoskeletal transport" EXACT []
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0051650 ! establishment of vesicle localization
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber
intersection_of: RO:0004009 GO:0031982 ! has primary input vesicle

[Term]
id: GO:0099519
name: dense core granule cytoskeletal transport
namespace: biological_process
def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451]
synonym: "dense core vesicle cytoskeletal trafficking" EXACT []
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
is_a: GO:1901950 ! dense core granule transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0030424 ! occurs in axon
intersection_of: RO:0002341 GO:0099513 ! results in transport along polymeric cytoskeletal fiber
intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule
relationship: BFO:0000066 GO:0030424 ! occurs in axon

[Term]
id: GO:0099522
name: cytosolic region
namespace: cellular_component
def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "region of cytosol" EXACT []
is_a: GO:0005829 ! cytosol
intersection_of: GO:0005829 ! cytosol
intersection_of: BFO:0000050 GO:0005829 ! part of cytosol
relationship: BFO:0000050 GO:0005829 ! part of cytosol

[Term]
id: GO:0099523
name: presynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099522 ! cytosolic region
intersection_of: GO:0005829 ! cytosol
intersection_of: BFO:0000050 GO:0005829 ! part of cytosol
intersection_of: BFO:0000050 GO:0098793 ! part of presynapse
relationship: BFO:0000050 GO:0098793 ! part of presynapse

[Term]
id: GO:0099524
name: postsynaptic cytosol
namespace: cellular_component
def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099522 ! cytosolic region
intersection_of: GO:0005829 ! cytosol
intersection_of: BFO:0000050 GO:0005829 ! part of cytosol
intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse
relationship: BFO:0000050 GO:0098794 ! part of postsynapse

[Term]
id: GO:0099528
name: G protein-coupled neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]
synonym: "G-protein coupled neurotransmitter receptor activity" EXACT []
is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0099531
name: presynaptic process involved in chemical synaptic transmission
namespace: biological_process
def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos]
subset: gocheck_obsoletion_candidate
subset: goslim_synapse
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse

[Term]
id: GO:0099536
name: synaptic signaling
namespace: biological_process
def: "Cell-cell signaling to, from or within a synapse." [GOC:dos]
subset: goslim_drosophila
subset: goslim_synapse
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa

[Term]
id: GO:0099537
name: trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099538
name: synaptic signaling via neuropeptide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling
intersection_of: GO:0099536 ! synaptic signaling
intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion
relationship: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion

[Term]
id: GO:0099540
name: trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
is_a: GO:0099538 ! synaptic signaling via neuropeptide
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion

[Term]
id: GO:0099541
name: trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid
relationship: RO:0002608 CHEBI:18059 ! process has causal agent lipid

[Term]
id: GO:0099546
name: protein catabolic process, modulating synaptic transmission
namespace: biological_process
def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
intersection_of: GO:0009056 ! catabolic process
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099547
name: regulation of translation at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140243 ! regulation of translation at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
intersection_of: RO:0002211 GO:0006412 ! regulates translation
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099550
name: trans-synaptic signaling, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099551
name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
intersection_of: RO:0002608 CHEBI:60466 ! process has causal agent peptide zwitterion

[Term]
id: GO:0099552
name: trans-synaptic signaling by lipid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
intersection_of: RO:0002608 CHEBI:18059 ! process has causal agent lipid

[Term]
id: GO:0099565
name: chemical synaptic transmission, postsynaptic
namespace: biological_process
def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0007166 ! cell surface receptor signaling pathway
intersection_of: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
relationship: BFO:0000050 GO:0007268 ! part of chemical synaptic transmission
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse

[Term]
id: GO:0099568
name: cytoplasmic region
namespace: cellular_component
def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos]
subset: gocheck_do_not_annotate
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm

[Term]
id: GO:0099569
name: presynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: BFO:0000050 GO:0098793 ! part of presynapse
relationship: BFO:0000050 GO:0098793 ! part of presynapse

[Term]
id: GO:0099571
name: postsynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: BFO:0000050 GO:0098794 ! part of postsynapse
relationship: BFO:0000050 GO:0098794 ! part of postsynapse

[Term]
id: GO:0099574
name: regulation of protein catabolic process at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140250 ! regulation protein catabolic process at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein

[Term]
id: GO:0099575
name: regulation of protein catabolic process at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099576
name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099577
name: regulation of translation at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140244 ! regulation of translation at presynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
intersection_of: RO:0002211 GO:0006412 ! regulates translation
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099578
name: regulation of translation at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140245 ! regulation of translation at postsynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
intersection_of: RO:0002211 GO:0006412 ! regulates translation
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission

[Term]
id: GO:0099601
name: regulation of neurotransmitter receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector function such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]
subset: gocheck_obsoletion_candidate
subset: goslim_synapse
is_a: GO:0010469 ! regulation of signaling receptor activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030594 ! regulates neurotransmitter receptor activity
relationship: RO:0002211 GO:0030594 ! regulates neurotransmitter receptor activity

[Term]
id: GO:0099612
name: protein localization to axon
namespace: biological_process
def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139]
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0030424 ! has target end location axon
relationship: RO:0002339 GO:0030424 ! has target end location axon

[Term]
id: GO:0099632
name: protein transport within plasma membrane
namespace: biological_process
def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos]
is_a: GO:0032594 ! protein transport within lipid bilayer
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0005886 ! occurs in plasma membrane
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: BFO:0000066 GO:0005886 ! occurs in plasma membrane

[Term]
id: GO:0099637
name: neurotransmitter receptor transport
namespace: biological_process
def: "The directed movement of neurotransmitter receptors." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015031 ! protein transport
is_a: GO:0031503 ! protein-containing complex localization
intersection_of: GO:0015031 ! protein transport
intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex
relationship: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex

[Term]
id: GO:0099640
name: axo-dendritic protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axonal protein transport" NARROW []
is_a: GO:0008088 ! axo-dendritic transport
is_a: GO:0098840 ! protein transport along microtubule
intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0099641
name: anterograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos]
subset: goslim_synapse
synonym: "anterograde axon cargo transport" BROAD []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport
is_a: GO:1905383 ! protein localization to presynapse
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0099642
name: retrograde axonal protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
subset: goslim_synapse
synonym: "retrograde axon cargo transport" BROAD []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0099640 ! axo-dendritic protein transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 PR:000000001 ! has primary input protein

[Term]
id: GO:0099643
name: signal release from synapse
namespace: biological_process
def: "Any signal release from a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0023061 ! signal release
intersection_of: GO:0023061 ! signal release
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: BFO:0000050 GO:0099536 ! part of synaptic signaling

[Term]
id: GO:0099738
name: cell cortex region
namespace: cellular_component
def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "perimembrane region" EXACT []
is_a: GO:0005938 ! cell cortex
is_a: GO:0099568 ! cytoplasmic region
intersection_of: GO:0005938 ! cell cortex
intersection_of: BFO:0000050 GO:0005938 ! part of cell cortex
relationship: BFO:0000050 GO:0005938 ! part of cell cortex

[Term]
id: GO:0100001
name: regulation of skeletal muscle contraction by action potential
namespace: biological_process
def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol]
is_a: GO:0001508 ! action potential
is_a: GO:0014819 ! regulation of skeletal muscle contraction
intersection_of: GO:0001508 ! action potential
intersection_of: RO:0002211 GO:0003009 ! regulates skeletal muscle contraction
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0101023
name: vascular endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774]
is_a: GO:0001935 ! endothelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell
relationship: RO:0012003 CL:0000071 ! acts on population of blood vessel endothelial cell

[Term]
id: GO:0101024
name: mitotic nuclear membrane organization
namespace: biological_process
def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872]
comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown.
synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0071763 ! nuclear membrane organization
intersection_of: BFO:0000050 GO:0140014 ! part of mitotic nuclear division
relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division

[Term]
id: GO:0101025
name: nuclear membrane biogenesis
namespace: biological_process
def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw]
is_a: GO:0044091 ! membrane biogenesis
intersection_of: GO:0044085 ! cellular component biogenesis
intersection_of: RO:0004008 GO:0031965 ! has primary output nuclear membrane
relationship: BFO:0000050 GO:0071763 ! part of nuclear membrane organization
relationship: RO:0004008 GO:0031965 ! has primary output nuclear membrane

[Term]
id: GO:0106027
name: neuron projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0043005 ! results in organization of neuron projection
relationship: RO:0002592 GO:0043005 ! results in organization of neuron projection
creation_date: 2017-06-23T18:30:18Z

[Term]
id: GO:0106110
name: vomitoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." [https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056]
synonym: "deoxynivalenol biosynthetic process" EXACT []
synonym: "DON biosynthetic process" EXACT []
synonym: "vomitoxin anabolism" EXACT []
synonym: "vomitoxin biosynthesis" EXACT []
synonym: "vomitoxin formation" EXACT []
synonym: "vomitoxin synthesis" EXACT []
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:0120255 ! olefinic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: hjd
creation_date: 2018-04-16T19:06:06Z

[Term]
id: GO:0106214
name: regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:1903358 ! regulation of Golgi organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus
relationship: RO:0002211 GO:0048280 ! regulates vesicle fusion with Golgi apparatus
creation_date: 2019-06-27T15:12:22Z

[Term]
id: GO:0106215
name: negative regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus
relationship: RO:0002212 GO:0048280 ! negatively regulates vesicle fusion with Golgi apparatus
creation_date: 2019-06-27T15:17:17Z

[Term]
id: GO:0106216
name: positive regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus
relationship: RO:0002213 GO:0048280 ! positively regulates vesicle fusion with Golgi apparatus
creation_date: 2019-06-27T15:20:59Z

[Term]
id: GO:0106259
name: symbiont-mediated cell-to-cell migration in host
namespace: biological_process
def: "The directional movement of a symbiont from one host cell to another." [GOC:vw, PMID:18456802, PMID:19262673, PMID:19816653, PMID:29567712]
synonym: "cell-to-cell migration in host" EXACT []
synonym: "symbiont-mediated dissemination across host cells" EXACT []
is_a: GO:0044001 ! migration in host
created_by: hjd
creation_date: 2020-05-01T14:09:35Z

[Term]
id: GO:0110011
name: regulation of basement membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071711 ! regulates basement membrane organization
relationship: RO:0002211 GO:0071711 ! regulates basement membrane organization

[Term]
id: GO:0110020
name: regulation of actomyosin structure organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0031032 ! regulates actomyosin structure organization
relationship: RO:0002211 GO:0031032 ! regulates actomyosin structure organization
creation_date: 2017-06-20T19:28:58Z

[Term]
id: GO:0110021
name: cardiac muscle myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0051450 ! myoblast proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast
relationship: RO:0012003 CL:0000513 ! acts on population of cardiac muscle myoblast
creation_date: 2017-06-29T14:35:24Z

[Term]
id: GO:0110022
name: regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation
relationship: RO:0002211 GO:0110021 ! regulates cardiac muscle myoblast proliferation
creation_date: 2017-06-29T15:11:47Z

[Term]
id: GO:0110023
name: negative regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation
is_a: GO:2000818 ! negative regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation
relationship: RO:0002212 GO:0110021 ! negatively regulates cardiac muscle myoblast proliferation
creation_date: 2017-06-29T15:18:30Z

[Term]
id: GO:0110024
name: positive regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation
is_a: GO:2000288 ! positive regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation
relationship: RO:0002213 GO:0110021 ! positively regulates cardiac muscle myoblast proliferation
creation_date: 2017-06-29T15:24:16Z

[Term]
id: GO:0110053
name: regulation of actin filament organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007015 ! regulates actin filament organization
relationship: RO:0002211 GO:0007015 ! regulates actin filament organization
creation_date: 2017-09-20T19:52:57Z

[Term]
id: GO:0110057
name: regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation
relationship: RO:0002211 GO:0060837 ! regulates blood vessel endothelial cell differentiation
creation_date: 2017-10-23T14:32:09Z

[Term]
id: GO:0110058
name: positive regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045603 ! positive regulation of endothelial cell differentiation
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation
relationship: RO:0002213 GO:0060837 ! positively regulates blood vessel endothelial cell differentiation
creation_date: 2017-10-23T14:38:19Z

[Term]
id: GO:0110059
name: negative regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation
relationship: RO:0002212 GO:0060837 ! negatively regulates blood vessel endothelial cell differentiation
creation_date: 2017-10-23T14:47:29Z

[Term]
id: GO:0110077
name: vesicle-mediated intercellular transport
namespace: biological_process
def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916]
synonym: "endosomal trafficking" RELATED []
is_a: GO:0010496 ! intercellular transport
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0010496 ! intercellular transport
intersection_of: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle
relationship: RO:0002608 GO:1903561 ! process has causal agent extracellular vesicle
creation_date: 2018-01-29T14:46:52Z

[Term]
id: GO:0110110
name: positive regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis
relationship: RO:0002213 GO:0009887 ! positively regulates animal organ morphogenesis
creation_date: 2018-07-05T14:10:14Z

[Term]
id: GO:0110111
name: negative regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis
relationship: RO:0002212 GO:0009887 ! negatively regulates animal organ morphogenesis
creation_date: 2018-07-05T14:25:21Z

[Term]
id: GO:0110116
name: regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation
relationship: RO:0002211 GO:0001751 ! regulates compound eye photoreceptor cell differentiation
creation_date: 2018-07-16T18:08:49Z

[Term]
id: GO:0110117
name: positive regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation
relationship: RO:0002213 GO:0001751 ! positively regulates compound eye photoreceptor cell differentiation
creation_date: 2018-07-16T18:13:28Z

[Term]
id: GO:0110118
name: negative regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation
relationship: RO:0002212 GO:0001751 ! negatively regulates compound eye photoreceptor cell differentiation
creation_date: 2018-07-16T18:15:52Z

[Term]
id: GO:0110122
name: myotube cell migration
namespace: biological_process
def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742]
is_a: GO:0014812 ! muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0002372 ! results in movement of myotube
relationship: RO:0002565 CL:0002372 ! results in movement of myotube
creation_date: 2018-08-22T20:58:09Z

[Term]
id: GO:0110123
name: regulation of myotube cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0110122 ! regulates myotube cell migration
relationship: RO:0002211 GO:0110122 ! regulates myotube cell migration
creation_date: 2018-08-22T21:06:53Z

[Term]
id: GO:0110124
name: positive regulation of myotube cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0110123 ! regulation of myotube cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0110122 ! positively regulates myotube cell migration
relationship: RO:0002213 GO:0110122 ! positively regulates myotube cell migration
creation_date: 2018-08-22T21:09:38Z

[Term]
id: GO:0110125
name: negative regulation of myotube cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0110123 ! regulation of myotube cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0110122 ! negatively regulates myotube cell migration
relationship: RO:0002212 GO:0110122 ! negatively regulates myotube cell migration
creation_date: 2018-08-22T21:12:47Z

[Term]
id: GO:0110141
name: L-glutamate import into mitochondrion
namespace: biological_process
def: "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix." [GOC:vw, PMID:30297026]
is_a: GO:0015813 ! L-glutamate transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
creation_date: 2019-04-24T19:13:46Z

[Term]
id: GO:0110165
name: cellular anatomical structure
namespace: cellular_component
def: "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses." [GOC:kmv]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cellular anatomical entity" EXACT []
is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
created_by: kmv
creation_date: 2019-08-12T18:01:37Z

[Term]
id: GO:0120006
name: regulation of glutamatergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905962 ! regulates glutamatergic neuron differentiation
relationship: RO:0002211 GO:1905962 ! regulates glutamatergic neuron differentiation
creation_date: 2017-03-01T16:10:27Z

[Term]
id: GO:0120007
name: negative regulation of glutamatergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905962 ! negatively regulates glutamatergic neuron differentiation
relationship: RO:0002212 GO:1905962 ! negatively regulates glutamatergic neuron differentiation
creation_date: 2017-03-01T16:25:50Z

[Term]
id: GO:0120008
name: positive regulation of glutamatergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905962 ! positively regulates glutamatergic neuron differentiation
relationship: RO:0002213 GO:1905962 ! positively regulates glutamatergic neuron differentiation
creation_date: 2017-03-01T16:35:45Z

[Term]
id: GO:0120025
name: plasma membrane bounded cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]
is_a: GO:0042995 ! cell projection
intersection_of: GO:0042995 ! cell projection
intersection_of: BFO:0000051 GO:0098590 ! has part plasma membrane region
relationship: BFO:0000051 GO:0098590 ! has part plasma membrane region
creation_date: 2017-03-21T17:26:07Z

[Term]
id: GO:0120031
name: plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]
synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection
relationship: RO:0002588 GO:0120025 ! results in assembly of plasma membrane bounded cell projection
creation_date: 2017-04-24T23:56:08Z

[Term]
id: GO:0120032
name: regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly
relationship: RO:0002211 GO:0120031 ! regulates plasma membrane bounded cell projection assembly
creation_date: 2017-04-26T04:27:04Z

[Term]
id: GO:0120033
name: negative regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly
relationship: RO:0002212 GO:0120031 ! negatively regulates plasma membrane bounded cell projection assembly
creation_date: 2017-04-26T04:34:31Z

[Term]
id: GO:0120034
name: positive regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly
relationship: RO:0002213 GO:0120031 ! positively regulates plasma membrane bounded cell projection assembly
creation_date: 2017-04-26T04:34:45Z

[Term]
id: GO:0120035
name: regulation of plasma membrane bounded cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]
is_a: GO:0031344 ! regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization
relationship: RO:0002211 GO:0120036 ! regulates plasma membrane bounded cell projection organization
creation_date: 2017-04-26T16:02:06Z

[Term]
id: GO:0120036
name: plasma membrane bounded cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]
is_a: GO:0030030 ! cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection
relationship: RO:0002592 GO:0120025 ! results in organization of plasma membrane bounded cell projection
creation_date: 2017-04-26T16:07:02Z

[Term]
id: GO:0120039
name: plasma membrane bounded cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc]
is_a: GO:0048858 ! cell projection morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection
relationship: RO:0002298 GO:0120025 ! results in morphogenesis of plasma membrane bounded cell projection
creation_date: 2017-04-28T23:39:37Z

[Term]
id: GO:0120111
name: neuron projection cytoplasm
namespace: cellular_component
def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha]
is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0043005 ! part of neuron projection
relationship: BFO:0000050 GO:0043005 ! part of neuron projection
creation_date: 2017-11-01T18:58:12Z

[Term]
id: GO:0120158
name: positive regulation of collagen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb]
synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process
relationship: RO:0002213 GO:0030574 ! positively regulates collagen catabolic process
creation_date: 2018-05-11T16:31:42Z

[Term]
id: GO:0120178
name: steroid hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln]
is_a: GO:0006694 ! steroid biosynthetic process
intersection_of: GO:0006694 ! steroid biosynthetic process
intersection_of: RO:0004008 CHEBI:26764 ! has primary output
relationship: RO:0004008 CHEBI:26764 ! has primary output
creation_date: 2019-05-20T22:34:00Z

[Term]
id: GO:0120186
name: negative regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]
synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905634 ! regulation of protein localization to chromatin
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin
relationship: RO:0002212 GO:0071168 ! negatively regulates protein localization to chromatin
creation_date: 2018-07-14T00:19:32Z

[Term]
id: GO:0120187
name: positive regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]
synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905634 ! regulation of protein localization to chromatin
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin
relationship: RO:0002213 GO:0071168 ! positively regulates protein localization to chromatin
creation_date: 2018-07-14T00:21:28Z

[Term]
id: GO:0120192
name: tight junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl]
synonym: "occluding cell junction assembly" EXACT [GOC:rl]
synonym: "occluding junction assembly" EXACT [GOC:rl]
is_a: GO:0007043 ! cell-cell junction assembly
is_a: GO:0120193 ! tight junction organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0070160 ! results in assembly of tight junction
relationship: RO:0002588 GO:0070160 ! results in assembly of tight junction
creation_date: 2018-08-14T22:48:05Z

[Term]
id: GO:0120193
name: tight junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:krc, GOC:rl]
synonym: "occluding cell junction organization" EXACT [GOC:rl]
synonym: "occluding junction organization" EXACT []
is_a: GO:0045216 ! cell-cell junction organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0070160 ! results in organization of tight junction
relationship: RO:0002592 GO:0070160 ! results in organization of tight junction
creation_date: 2018-08-14T23:05:40Z

[Term]
id: GO:0120222
name: regulation of blastocyst development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001824 ! regulates blastocyst development
relationship: RO:0002211 GO:0001824 ! regulates blastocyst development
creation_date: 2020-02-17T19:59:20Z

[Term]
id: GO:0120223
name: larynx morphogenesis
namespace: biological_process
def: "The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282]
synonym: "laryngeal morphogenesis" EXACT [GOC:krc, PMID:28177282]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001737 ! results in morphogenesis of larynx
relationship: BFO:0000050 GO:0120224 ! part of larynx development
relationship: RO:0002298 UBERON:0001737 ! results in morphogenesis of larynx
creation_date: 2020-02-22T01:42:04Z

[Term]
id: GO:0120224
name: larynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001737 ! results in development of larynx
relationship: BFO:0000050 GO:0060541 ! part of respiratory system development
relationship: RO:0002296 UBERON:0001737 ! results in development of larynx
creation_date: 2020-02-24T17:13:10Z

[Term]
id: GO:0120229
name: protein localization to motile cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780]
synonym: "protein localization to nonmotile primary cilium" RELATED []
is_a: GO:0061512 ! protein localization to cilium
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0031514 ! has target end location motile cilium
relationship: RO:0002339 GO:0031514 ! has target end location motile cilium
creation_date: 2020-06-05T23:43:04Z

[Term]
id: GO:0120254
name: olefinic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]
synonym: "alkene substituted compound metabolic process" EXACT []
synonym: "alkene substituted compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
created_by: krc
creation_date: 2020-09-02T23:13:44Z

[Term]
id: GO:0120255
name: olefinic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]
synonym: "alkene substituted compound anabolic process" EXACT [GOC:krc]
synonym: "alkene substituted compound anabolism" EXACT [GOC:krc]
synonym: "alkene substituted compound biosynthesis" EXACT [GOC:krc]
synonym: "alkene substituted compound biosynthetic process" EXACT [GOC:krc]
synonym: "alkene substituted compound synthesis" EXACT [GOC:krc]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0120254 ! olefinic compound metabolic process
created_by: krc
creation_date: 2020-09-02T23:30:20Z

[Term]
id: GO:0120261
name: regulation of heterochromatin organization
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of heterochromatin organization." [GOC:krc]
is_a: GO:1902275 ! regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070828 ! regulates heterochromatin organization
relationship: RO:0002211 GO:0070828 ! regulates heterochromatin organization
creation_date: 2020-09-29T20:00:04Z

[Term]
id: GO:0120262
name: negative regulation of heterochromatin organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization." [GOC:krc]
synonym: "down regulation of heterochromatin organization" EXACT []
synonym: "down-regulation of heterochromatin organization" EXACT []
synonym: "downregulation of heterochromatin organization" EXACT []
synonym: "inhibition of heterochromatin organization" NARROW []
is_a: GO:0120261 ! regulation of heterochromatin organization
is_a: GO:1905268 ! negative regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070828 ! negatively regulates heterochromatin organization
relationship: RO:0002212 GO:0070828 ! negatively regulates heterochromatin organization
creation_date: 2020-09-29T20:12:30Z

[Term]
id: GO:0120263
name: positive regulation of heterochromatin organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heterochromatin organization." [GOC:krc]
synonym: "activation of heterochromatin organization" NARROW []
synonym: "stimulation of heterochromatin organization" NARROW []
synonym: "up regulation of heterochromatin organization" EXACT []
synonym: "up-regulation of heterochromatin organization" EXACT []
synonym: "upregulation of heterochromatin organization" EXACT []
is_a: GO:0120261 ! regulation of heterochromatin organization
is_a: GO:1905269 ! positive regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070828 ! positively regulates heterochromatin organization
relationship: RO:0002213 GO:0070828 ! positively regulates heterochromatin organization
creation_date: 2020-09-29T20:19:19Z

[Term]
id: GO:0120275
name: cerebral blood circulation
namespace: biological_process
def: "The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:krc, PMID:25397684]
synonym: "cerebrum blood circulation" EXACT []
synonym: "telencephelon blood circulation" EXACT []
is_a: GO:0008015 ! blood circulation
intersection_of: GO:0008015 ! blood circulation
intersection_of: BFO:0000066 UBERON:0001893 ! occurs in telencephalon
relationship: BFO:0000066 UBERON:0001893 ! occurs in telencephalon
creation_date: 2020-10-20T19:13:51Z

[Term]
id: GO:0120276
name: regulation of cerebral blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684]
synonym: "regulation of cerebrum blood circulation" EXACT []
synonym: "regulation of telencephalon blood circulation" EXACT []
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0120275 ! regulates cerebral blood circulation
relationship: RO:0002211 GO:0120275 ! regulates cerebral blood circulation
creation_date: 2020-10-21T06:52:22Z

[Term]
id: GO:0120277
name: positive regulation of cerebral blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684]
synonym: "activation of cerebral blood circulation" NARROW []
synonym: "positive regulation of cerebrum blood circulation" EXACT []
synonym: "positive regulation of telencephalon blood circulation" EXACT []
synonym: "up regulation of cerebral blood circulation" EXACT []
synonym: "up-regulation of cerebral blood circulation" EXACT []
synonym: "upregulation of cerebral blood circulation" EXACT []
is_a: GO:0120276 ! regulation of cerebral blood circulation
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0120275 ! positively regulates cerebral blood circulation
relationship: RO:0002213 GO:0120275 ! positively regulates cerebral blood circulation
creation_date: 2020-10-21T06:55:42Z

[Term]
id: GO:0120278
name: negative regulation of cerebral blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684]
synonym: "down regulation of cerebral blood circulation" EXACT []
synonym: "down-regulation of cerebral blood circulation" EXACT []
synonym: "downregulation of cerebral blood circulation" EXACT []
synonym: "inhibition of cerebral blood circulation" NARROW []
synonym: "negative regulation of cerebrum blood circulation" EXACT []
synonym: "negative regulation of telencephalon blood circulation" EXACT []
is_a: GO:0120276 ! regulation of cerebral blood circulation
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0120275 ! negatively regulates cerebral blood circulation
relationship: RO:0002212 GO:0120275 ! negatively regulates cerebral blood circulation
creation_date: 2020-10-21T07:02:05Z

[Term]
id: GO:0120305
name: regulation of pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043473 ! regulates pigmentation
relationship: RO:0002211 GO:0043473 ! regulates pigmentation
created_by: krc
creation_date: 2021-02-09T19:37:35Z

[Term]
id: GO:0120331
name: endothelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824]
is_a: GO:0072175 ! epithelial tube formation
intersection_of: GO:0035148 ! tube formation
intersection_of: RO:0002297 UBERON:0003915 ! results in formation of endothelial tube
relationship: BFO:0000050 GO:0061154 ! part of endothelial tube morphogenesis
relationship: RO:0002297 UBERON:0003915 ! results in formation of endothelial tube
creation_date: 2022-05-25T16:17:59Z

[Term]
id: GO:0140001
name: morula formation
namespace: biological_process
def: "The initial formation of a spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [PMID:37935903, PMID:38386558, PMID:39361745]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0000085 ! results in formation of morula
relationship: RO:0002297 UBERON:0000085 ! results in formation of morula
creation_date: 2024-11-12T09:29:56Z

[Term]
id: GO:0140013
name: meiotic nuclear division
namespace: biological_process
def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324]
subset: goslim_generic
synonym: "meiosis" EXACT []
is_a: GO:0000280 ! nuclear division
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000280 ! nuclear division
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle
created_by: pg
creation_date: 2017-03-23T09:40:00Z

[Term]
id: GO:0140014
name: mitotic nuclear division
namespace: biological_process
def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
synonym: "mitosis" EXACT []
is_a: GO:0000280 ! nuclear division
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000280 ! nuclear division
intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle
creation_date: 2017-03-23T14:44:23Z

[Term]
id: GO:0140029
name: exocytic process
namespace: biological_process
def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: BFO:0000050 GO:0006887 ! part of exocytosis
relationship: BFO:0000050 GO:0006887 ! part of exocytosis
creation_date: 2017-05-15T13:20:45Z

[Term]
id: GO:0140039
name: cell-cell adhesion in response to extracellular stimulus
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911]
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus
relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus
creation_date: 2017-05-24T11:37:30Z

[Term]
id: GO:0140053
name: mitochondrial gene expression
namespace: biological_process
def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308]
subset: goslim_generic
subset: goslim_pombe
is_a: GO:0010467 ! gene expression
intersection_of: GO:0010467 ! gene expression
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
creation_date: 2017-06-26T10:57:45Z

[Term]
id: GO:0140056
name: organelle localization by membrane tethering
namespace: biological_process
def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684]
subset: goslim_pombe
is_a: GO:0022406 ! membrane docking
is_a: GO:0051640 ! organelle localization
creation_date: 2017-06-27T09:58:51Z

[Term]
id: GO:0140096
name: catalytic activity, acting on a protein
namespace: molecular_function
def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0003824 ! catalytic activity
intersection_of: GO:0003824 ! catalytic activity
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0004009 PR:000000001 ! has primary input protein
created_by: pg
creation_date: 2017-09-14T10:32:59Z

[Term]
id: GO:0140097
name: catalytic activity, acting on DNA
namespace: molecular_function
def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid
intersection_of: GO:0003824 ! catalytic activity
intersection_of: RO:0004009 CHEBI:16991 ! has primary input
relationship: RO:0004009 CHEBI:16991 ! has primary input
creation_date: 2017-09-14T12:03:51Z

[Term]
id: GO:0140098
name: catalytic activity, acting on RNA
namespace: molecular_function
def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid
intersection_of: GO:0003824 ! catalytic activity
intersection_of: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
relationship: RO:0004009 CHEBI:33697 ! has primary input ribonucleic acid
creation_date: 2017-09-14T12:05:21Z

[Term]
id: GO:0140101
name: catalytic activity, acting on a tRNA
namespace: molecular_function
def: "Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]
comment: Note that this term excludes activities for which a charged tRNA acts as an amino acid donor.
is_a: GO:0140098 ! catalytic activity, acting on RNA
intersection_of: GO:0003824 ! catalytic activity
intersection_of: RO:0004009 CHEBI:17843 ! has primary input
relationship: RO:0004009 CHEBI:17843 ! has primary input
creation_date: 2017-09-15T18:41:41Z

[Term]
id: GO:0140103
name: catalytic activity, acting on a glycoprotein
namespace: molecular_function
def: "Catalysis of a biochemical reaction in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]
is_a: GO:0140096 ! catalytic activity, acting on a protein
intersection_of: GO:0003824 ! catalytic activity
intersection_of: RO:0004009 CHEBI:17089 ! has primary input
relationship: RO:0004009 CHEBI:17089 ! has primary input
creation_date: 2017-09-15T19:27:54Z

[Term]
id: GO:0140112
name: extracellular vesicle biogenesis
namespace: biological_process
def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435]
synonym: "extracellular vesicle assembly" EXACT []
is_a: GO:0044085 ! cellular component biogenesis
creation_date: 2017-10-23T11:53:42Z

[Term]
id: GO:0140115
name: export across plasma membrane
namespace: biological_process
def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]
synonym: "efflux" BROAD []
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0140352 ! export from cell
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002342 GO:0005886 ! results in transport across plasma membrane
creation_date: 2017-10-24T14:38:16Z

[Term]
id: GO:0140131
name: positive regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis." [PMID:19255442]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000403 ! positive regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048247 ! positively regulates lymphocyte chemotaxis
relationship: RO:0002213 GO:0048247 ! positively regulates lymphocyte chemotaxis
creation_date: 2017-11-02T10:26:40Z

[Term]
id: GO:0140139
name: solid phase of basement membrane
namespace: cellular_component
def: "The solid compartment of the basement membrane ECM, including a specific subset of basement membrane collagens and basement membrane glycoproteins like laminins or nidogens." [PMID:33972551]
is_a: GO:0030312 ! external encapsulating structure
relationship: BFO:0000050 GO:0005604 ! part of basement membrane
creation_date: 2025-03-20T11:44:22Z

[Term]
id: GO:0140143
name: collagenous component of basement membrane
namespace: cellular_component
def: "Collagenous component of basement membrane ECMs, including collagen IV and other types of collagen specifically expressed in basement membrane." [PMID:21123617, PMID:21421915, PMID:28040522, PMID:28324731, PMID:31387942, PMID:39223427]
is_a: GO:0030312 ! external encapsulating structure
relationship: BFO:0000050 GO:0140139 ! part of solid phase of basement membrane
creation_date: 2025-03-20T11:47:59Z

[Term]
id: GO:0140151
name: solid phase of interstitial matrix
namespace: cellular_component
def: "The solid compartment of the interstitial matrix, including interstitial collagens such as fibrillar and fibril-associated collagens and non-collagenous glycoproteins like fibronectin and elastin." [PMID:3284468, PMID:34807416]
is_a: GO:0030312 ! external encapsulating structure
relationship: BFO:0000050 GO:0005614 ! part of interstitial matrix
creation_date: 2025-03-20T11:44:22Z

[Term]
id: GO:0140152
name: collagenous component of interstitial matrix
namespace: cellular_component
def: "Main components of the interstitial matrix solid phase, including fibrillar and fibril-associated collagens." [PMID:12064927, PMID:17550969, PMID:21421911, PMID:28101870, PMID:39223427]
is_a: GO:0030312 ! external encapsulating structure
relationship: BFO:0000050 GO:0140151 ! part of solid phase of interstitial matrix
creation_date: 2025-03-20T11:47:59Z

[Term]
id: GO:0140154
name: chicken-wire-like collagen network
namespace: cellular_component
def: "Network-forming collagens can either form a chicken-wire-like network or a hexagonal network. Collagen type IV forms a chicken-wire-like structure and is found in the basement membrane." [PMID:21421911, PMID:21421915, PMID:31387942]
is_a: GO:0098645 ! collagen network
relationship: BFO:0000050 GO:0140143 ! part of collagenous component of basement membrane
creation_date: 2025-03-26T06:42:53Z

[Term]
id: GO:0140231
name: anterograde axonal transport of neurotransmitter receptor complex
namespace: biological_process
def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963]
subset: goslim_synapse
is_a: GO:0097120 ! receptor localization to synapse
is_a: GO:0099637 ! neurotransmitter receptor transport
is_a: GO:0099641 ! anterograde axonal protein transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0098878 ! has primary input neurotransmitter receptor complex
creation_date: 2018-07-09T09:41:37Z

[Term]
id: GO:0140236
name: translation at presynapse
namespace: biological_process
def: "Translation that occurs at the presynapse." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse
intersection_of: GO:0006412 ! translation
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
creation_date: 2018-07-13T13:00:33Z

[Term]
id: GO:0140237
name: translation at presynapse, modulating chemical synaptic transmission
namespace: biological_process
def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140236 ! translation at presynapse
intersection_of: GO:0006412 ! translation
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
intersection_of: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
relationship: RO:0002211 GO:0007268 ! regulates chemical synaptic transmission
creation_date: 2018-07-13T13:07:23Z

[Term]
id: GO:0140238
name: presynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006897 ! endocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse
intersection_of: GO:0006897 ! endocytosis
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
creation_date: 2018-07-15T07:33:55Z

[Term]
id: GO:0140239
name: postsynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006897 ! endocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse
intersection_of: GO:0006897 ! endocytosis
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse
creation_date: 2018-07-15T07:38:27Z

[Term]
id: GO:0140241
name: translation at synapse
namespace: biological_process
def: "Translation that occurs at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006412 ! translation
intersection_of: GO:0006412 ! translation
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
creation_date: 2018-07-15T09:23:12Z

[Term]
id: GO:0140242
name: translation at postsynapse
namespace: biological_process
def: "Translation that occurs at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse
intersection_of: GO:0006412 ! translation
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse
creation_date: 2018-07-15T09:26:27Z

[Term]
id: GO:0140243
name: regulation of translation at synapse
namespace: biological_process
def: "Any process that regulates translation occurring at the synapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
intersection_of: RO:0002211 GO:0006412 ! regulates translation
relationship: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
creation_date: 2018-07-15T09:38:26Z

[Term]
id: GO:0140244
name: regulation of translation at presynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
intersection_of: RO:0002211 GO:0006412 ! regulates translation
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
creation_date: 2018-07-15T09:38:33Z

[Term]
id: GO:0140245
name: regulation of translation at postsynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
intersection_of: RO:0002211 GO:0006412 ! regulates translation
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse
creation_date: 2018-07-15T09:38:54Z

[Term]
id: GO:0140246
name: protein catabolic process at synapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0030163 ! protein catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
relationship: RO:0004009 CHEBI:36080 ! has primary input protein
creation_date: 2018-07-15T10:12:51Z

[Term]
id: GO:0140247
name: protein catabolic process at presynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
intersection_of: GO:0009056 ! catabolic process
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
creation_date: 2018-07-15T10:23:49Z

[Term]
id: GO:0140249
name: protein catabolic process at postsynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
intersection_of: GO:0009056 ! catabolic process
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse
creation_date: 2018-07-15T10:25:04Z

[Term]
id: GO:0140250
name: regulation protein catabolic process at synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0045202 ! occurs in synapse
intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000066 GO:0045202 ! occurs in synapse
relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
relationship: RO:0004009 CHEBI:36080 ! has primary input protein
creation_date: 2018-07-15T10:34:56Z

[Term]
id: GO:0140251
name: regulation protein catabolic process at presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0098793 ! occurs in presynapse
intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000066 GO:0098793 ! occurs in presynapse
creation_date: 2018-07-15T10:35:39Z

[Term]
id: GO:0140252
name: regulation protein catabolic process at postsynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000066 GO:0098794 ! occurs in postsynapse
intersection_of: RO:0002211 GO:0009056 ! regulates catabolic process
intersection_of: RO:0004009 CHEBI:36080 ! has primary input protein
relationship: BFO:0000066 GO:0098794 ! occurs in postsynapse
creation_date: 2018-07-15T10:35:56Z

[Term]
id: GO:0140253
name: cell-cell fusion
namespace: biological_process
def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion]
synonym: "cell cell fusion" EXACT []
synonym: "cell fusion" BROAD []
is_a: GO:0009987 ! cellular process
relationship: BFO:0000051 GO:0045026 ! has part plasma membrane fusion
creation_date: 2018-08-13T18:38:18Z

[Term]
id: GO:0140272
name: exogenous protein binding
namespace: molecular_function
def: "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068]
comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant.
is_a: GO:0005515 ! protein binding
created_by: pg
creation_date: 2018-10-01T10:03:21Z

[Term]
id: GO:0140297
name: DNA-binding transcription factor binding
namespace: molecular_function
def: "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]
synonym: "activating transcription factor binding" RELATED []
synonym: "repressing transcription factor binding" RELATED []
synonym: "transcription activator binding" RELATED []
is_a: GO:0008134 ! transcription factor binding
creation_date: 2018-11-28T12:48:20Z

[Term]
id: GO:0140318
name: protein transporter activity
namespace: molecular_function
def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]
comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.
synonym: "protein carrier activity" RELATED []
synonym: "protein transport chaperone" RELATED []
xref: Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome"
xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network"
xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane"
is_a: GO:0005215 ! transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: RO:0004009 PR:000000001 ! has primary input protein
relationship: RO:0004009 PR:000000001 ! has primary input protein
creation_date: 2019-04-01T10:41:38Z

[Term]
id: GO:0140352
name: export from cell
namespace: biological_process
def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg]
synonym: "efflux" BROAD []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
relationship: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure
relationship: RO:0002339 GO:0005576 ! has target end location extracellular region
created_by: pg
creation_date: 2019-05-22T11:20:45Z

[Term]
id: GO:0140353
name: lipid export from cell
namespace: biological_process
def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg]
synonym: "lipid efflux" BROAD []
is_a: GO:0006869 ! lipid transport
is_a: GO:0140352 ! export from cell
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005622 ! has target start location intracellular anatomical structure
intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
creation_date: 2019-05-22T11:33:07Z

[Term]
id: GO:0140354
name: lipid import into cell
namespace: biological_process
def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg]
synonym: "lipid uptake" BROAD []
is_a: GO:0006869 ! lipid transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
relationship: RO:0002338 GO:0005576 ! has target start location extracellular region
relationship: RO:0002339 GO:0005622 ! has target end location intracellular anatomical structure
creation_date: 2019-05-22T11:38:15Z

[Term]
id: GO:0140375
name: immune receptor activity
namespace: molecular_function
def: "Receiving a signal and transmitting it in a cell to initiate an immune response." [PMID:31415752, Wikipedia:Immune_receptor]
is_a: GO:0038023 ! signaling receptor activity
creation_date: 2019-10-18T14:11:15Z

[Term]
id: GO:0140513
name: nuclear protein-containing complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]
subset: gocheck_do_not_annotate
synonym: "nuclear complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: BFO:0000050 GO:0005634 ! part of nucleus
relationship: BFO:0000050 GO:0005634 ! part of nucleus
created_by: pg
creation_date: 2020-09-09T05:12:38Z

[Term]
id: GO:0140546
name: defense response to symbiont
namespace: biological_process
def: "Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host." [GOC:pg]
is_a: GO:0098542 ! defense response to other organism
created_by: pg
creation_date: 2020-11-11T17:19:06Z

[Term]
id: GO:0140572
name: vacuole fission
namespace: biological_process
def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199]
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: GOREL:0002004 GO:0005773 ! results in fission of vacuole
relationship: GOREL:0002004 GO:0005773 ! results in fission of vacuole
created_by: pg
creation_date: 2021-01-04T10:17:58Z

[Term]
id: GO:0140640
name: catalytic activity, acting on a nucleic acid
namespace: molecular_function
def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg]
is_a: GO:0003824 ! catalytic activity
intersection_of: GO:0003824 ! catalytic activity
intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
creation_date: 2021-05-11T06:31:07Z

[Term]
id: GO:0140650
name: radial glia-guided pyramidal neuron migration
namespace: biological_process
def: "The radial migration of a pyramidal neuron along radial glial cells." [PMID:3760547]
synonym: "radial glia-dependent neuronal migration" EXACT []
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000598 ! results in movement of pyramidal neuron
relationship: RO:0002565 CL:0000598 ! results in movement of pyramidal neuron
creation_date: 2021-05-25T12:48:12Z

[Term]
id: GO:0140657
name: ATP-dependent activity
namespace: molecular_function
def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]
comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "ATP hydrolysis-dependent activity" EXACT []
synonym: "ATPase activity" EXACT []
synonym: "ATPase activity, coupled" EXACT []
synonym: "ATPase-dependent activity" EXACT []
is_a: GO:0003674 ! molecular_function
intersection_of: GO:0003674 ! molecular_function
intersection_of: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity
relationship: BFO:0000051 GO:0016887 ! has part ATP hydrolysis activity
created_by: pg
creation_date: 2021-06-15T07:35:06Z

[Term]
id: GO:0140694
name: membraneless organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]
synonym: "non-membrane-bounded organelle assembly" EXACT []
synonym: "non-membrane-bounded organelle formation" EXACT []
synonym: "non-membrane-enclosed organelle assembly" EXACT []
synonym: "non-membrane-enclosed organelle formation" EXACT []
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle
relationship: RO:0002588 GO:0043228 ! results in assembly of membraneless organelle
creation_date: 2021-08-09T15:30:06Z

[Term]
id: GO:0140820
name: cytosol to Golgi apparatus transport
namespace: biological_process
def: "The directed movement of substances from the cytosol into the Golgi apparatus of a cell." [PMID:28373556]
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005794 ! has target end location Golgi apparatus
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005794 ! has target end location Golgi apparatus
creation_date: 2022-05-16T06:59:22Z

[Term]
id: GO:0140899
name: plastid gene expression
namespace: biological_process
def: "The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:28377785]
is_a: GO:0010467 ! gene expression
intersection_of: GO:0010467 ! gene expression
intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid
relationship: BFO:0000066 GO:0009536 ! occurs in plastid
creation_date: 2022-08-17T10:34:35Z

[Term]
id: GO:0141187
name: nucleic acid biosynthetic process
namespace: biological_process
def: "The biosynthetic process resulting in the formation of a nucleic acid." [GOC:dph, GOC:tb]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
is_a: GO:0090304 ! nucleic acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33696 ! has primary output nucleic acid
relationship: RO:0004008 CHEBI:33696 ! has primary output nucleic acid
created_by: pg
creation_date: 2024-03-25T07:33:40Z

[Term]
id: GO:0141188
name: nucleic acid catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of a nucleic acid." [GOC:curators]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
is_a: GO:0090304 ! nucleic acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
relationship: RO:0004009 CHEBI:33696 ! has primary input nucleic acid
creation_date: 2024-03-25T07:35:06Z

[Term]
id: GO:0150031
name: regulation of protein localization to lysosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061462 ! regulates protein localization to lysosome
relationship: RO:0002211 GO:0061462 ! regulates protein localization to lysosome
creation_date: 2018-02-06T17:07:03Z

[Term]
id: GO:0150032
name: positive regulation of protein localization to lysosome
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc]
is_a: GO:0150031 ! regulation of protein localization to lysosome
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061462 ! positively regulates protein localization to lysosome
relationship: RO:0002213 GO:0061462 ! positively regulates protein localization to lysosome
creation_date: 2018-02-06T17:11:02Z

[Term]
id: GO:0150033
name: negative regulation of protein localization to lysosome
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806]
is_a: GO:0150031 ! regulation of protein localization to lysosome
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061462 ! negatively regulates protein localization to lysosome
relationship: RO:0002212 GO:0061462 ! negatively regulates protein localization to lysosome
creation_date: 2018-02-06T17:14:16Z

[Term]
id: GO:0150052
name: regulation of postsynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854]
subset: goslim_synapse
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099175 ! regulation of postsynapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099068 ! regulates postsynapse assembly
relationship: RO:0002211 GO:0099068 ! regulates postsynapse assembly
creation_date: 2018-05-08T16:38:55Z

[Term]
id: GO:0150063
name: visual system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727]
synonym: "optic pathway development" RELATED []
synonym: "visual pathway development" RELATED []
is_a: GO:0048880 ! sensory system development
creation_date: 2018-07-23T10:31:58Z

[Term]
id: GO:0150076
name: neuroinflammatory response
namespace: biological_process
def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
synonym: "nerve tissue inflammatory response" EXACT []
synonym: "nervous tissue inflammatory response" EXACT []
synonym: "neural tissue inflammatory response" EXACT []
is_a: GO:0006954 ! inflammatory response
creation_date: 2018-07-26T12:25:34Z

[Term]
id: GO:0150077
name: regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0150076 ! regulates neuroinflammatory response
relationship: RO:0002211 GO:0150076 ! regulates neuroinflammatory response
creation_date: 2018-07-26T12:32:18Z

[Term]
id: GO:0150078
name: positive regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc]
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0150077 ! regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0150076 ! positively regulates neuroinflammatory response
relationship: RO:0002213 GO:0150076 ! positively regulates neuroinflammatory response
creation_date: 2018-07-26T12:35:50Z

[Term]
id: GO:0150079
name: negative regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423]
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0150077 ! regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0150076 ! negatively regulates neuroinflammatory response
relationship: RO:0002212 GO:0150076 ! negatively regulates neuroinflammatory response
creation_date: 2018-07-26T12:38:08Z

[Term]
id: GO:0150098
name: glial cell-neuron signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440]
synonym: "glia-neuron signaling" EXACT []
synonym: "glia-neuron signalling" EXACT []
synonym: "glia-neurone signaling" EXACT []
synonym: "glia-neurone signalling" EXACT []
synonym: "glial cell- neuron signalling" EXACT []
synonym: "glial cell-neurone signalling" EXACT []
synonym: "glial cell-neurone singaling" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000125 ! has start location glial cell
intersection_of: RO:0002232 CL:0000540 ! has end location neuron
relationship: RO:0002231 CL:0000125 ! has start location glial cell
relationship: RO:0002232 CL:0000540 ! has end location neuron
creation_date: 2018-12-17T12:28:09Z

[Term]
id: GO:0150099
name: neuron-glial cell signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368]
synonym: "neuron-glia signaling" EXACT []
synonym: "neuron-glia signalling" EXACT []
synonym: "neuron-glial cell signalling" EXACT []
synonym: "neurone-glia signaling" EXACT []
synonym: "neurone-glia signalling" EXACT []
synonym: "neurone-glial cell signaling" EXACT []
synonym: "neurone-glial cell signalling" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: RO:0002231 CL:0000540 ! has start location neuron
intersection_of: RO:0002232 CL:0000125 ! has end location glial cell
relationship: RO:0002231 CL:0000540 ! has start location neuron
relationship: RO:0002232 CL:0000125 ! has end location glial cell
creation_date: 2018-12-17T12:30:12Z

[Term]
id: GO:0150102
name: negative regulation of monocyte activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation." [GOC:aruk, PMID:15597323]
synonym: "repression of monocyte activation" EXACT []
is_a: GO:0002695 ! negative regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042117 ! negatively regulates monocyte activation
relationship: RO:0002212 GO:0042117 ! negatively regulates monocyte activation
creation_date: 2019-04-26T20:01:24Z

[Term]
id: GO:0150105
name: protein localization to cell-cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:1902414 ! protein localization to cell junction
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005911 ! has target end location cell-cell junction
relationship: RO:0002339 GO:0005911 ! has target end location cell-cell junction
creation_date: 2019-06-11T11:00:18Z

[Term]
id: GO:0150106
name: regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction
relationship: RO:0002211 GO:0150105 ! regulates protein localization to cell-cell junction
creation_date: 2019-06-11T11:17:15Z

[Term]
id: GO:0150107
name: positive regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction
relationship: RO:0002213 GO:0150105 ! positively regulates protein localization to cell-cell junction
creation_date: 2019-06-11T11:23:58Z

[Term]
id: GO:0150111
name: regulation of transepithelial transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070633 ! regulates transepithelial transport
relationship: RO:0002211 GO:0070633 ! regulates transepithelial transport
creation_date: 2019-09-15T07:16:49Z

[Term]
id: GO:0150119
name: negative regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc]
synonym: "negative regulation of protein localisation to cell-cell junction" EXACT []
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction
relationship: RO:0002212 GO:0150105 ! negatively regulates protein localization to cell-cell junction
creation_date: 2019-11-21T13:53:34Z

[Term]
id: GO:0150146
name: cell junction disassembly
namespace: biological_process
def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0030054 ! results in disassembly of cell junction
relationship: RO:0002590 GO:0030054 ! results in disassembly of cell junction
creation_date: 2019-12-08T11:12:13Z

[Term]
id: GO:0150147
name: cell-cell junction disassembly
namespace: biological_process
def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267]
is_a: GO:0045216 ! cell-cell junction organization
is_a: GO:0150146 ! cell junction disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction
relationship: RO:0002590 GO:0005911 ! results in disassembly of cell-cell junction
creation_date: 2019-12-08T11:16:14Z

[Term]
id: GO:0160038
name: somatic sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain." [PMID:25832476, PMID:31399790]
synonym: "somatosensory system development" EXACT []
is_a: GO:0048880 ! sensory system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0003942 ! results in development of somatosensory system
relationship: RO:0002296 UBERON:0003942 ! results in development of somatosensory system
creation_date: 2022-07-07T16:49:26Z

[Term]
id: GO:0160043
name: catecholamine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter." [PMID:10191060]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0050432 ! catecholamine secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
creation_date: 2022-08-17T00:36:44Z

[Term]
id: GO:0160048
name: craniofacial suture closure
namespace: biological_process
def: "The process of fusing together the edges of a craniofacial suture." [PMID:33842480]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: RO:0012008 UBERON:0009198 ! results in fusion of craniofacial suture
relationship: RO:0012008 UBERON:0009198 ! results in fusion of craniofacial suture
creation_date: 2022-08-19T23:18:54Z

[Term]
id: GO:0160093
name: chordate pharynx development
namespace: biological_process
def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903]
is_a: GO:0060465 ! pharynx development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx
relationship: RO:0002296 UBERON:0001042 ! results in development of chordate pharynx
creation_date: 2023-08-29T21:05:28Z

[Term]
id: GO:0160307
name: protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protein." [Wikipedia:Protein_biosynthesis]
synonym: "protein biosynthesis" EXACT []
synonym: "protein synthesis" EXACT []
is_a: GO:0006412 ! translation
intersection_of: GO:0009059 ! macromolecule biosynthetic process
intersection_of: BFO:0000051 GO:0043039 ! has part tRNA aminoacylation
intersection_of: RO:0004008 PR:000000001 ! has primary output protein
relationship: BFO:0000051 GO:0043039 ! has part tRNA aminoacylation
creation_date: 2025-09-29T23:16:32Z

[Term]
id: GO:0170033
name: L-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an L-amino acid." [GOC:edw]
synonym: "L-alpha-amino acid metabolism" EXACT []
synonym: "L-amino acid metabolism" EXACT []
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:59869 ! has primary input or output L-alpha-amino acid zwitterion
relationship: RO:0004007 CHEBI:59869 ! has primary input or output L-alpha-amino acid zwitterion
created_by: ew
creation_date: 2023-11-20T23:41:23Z

[Term]
id: GO:0170034
name: L-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-amino acids, the L-enantiomers of amino acids." [GOC:edw]
synonym: "L-amino acid anabolism" EXACT []
synonym: "L-amino acid biosynthesis" EXACT []
synonym: "L-amino acid formation" EXACT []
synonym: "L-amino acid synthesis" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:59869 ! has primary output L-alpha-amino acid zwitterion
relationship: RO:0004008 CHEBI:59869 ! has primary output L-alpha-amino acid zwitterion
created_by: ew
creation_date: 2023-11-20T23:42:06Z

[Term]
id: GO:0170035
name: L-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an L-amino acid." [GOC:edw]
synonym: "L-amino acid breakdown" EXACT []
synonym: "L-amino acid catabolism" EXACT []
synonym: "L-amino acid degradation" EXACT []
is_a: GO:0170033 ! L-amino acid metabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
creation_date: 2023-11-21T00:55:07Z

[Term]
id: GO:0170036
name: import into the mitochondrion
namespace: biological_process
def: "The directed movement of substances from the cytosol into the mitochondrion." [GOC:ew]
is_a: GO:1990542 ! mitochondrial transmembrane transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
creation_date: 2023-11-30T20:56:49Z

[Term]
id: GO:0170037
name: export from the mitochondrion
namespace: biological_process
def: "The directed movement of substances from the mitochondrion to the cytosol." [GOC:ew]
is_a: GO:1990542 ! mitochondrial transmembrane transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
relationship: RO:0002338 GO:0005759 ! has target start location mitochondrial matrix
relationship: RO:0002339 GO:0005829 ! has target end location cytosol
creation_date: 2023-11-30T21:03:28Z

[Term]
id: GO:0170038
name: proteinogenic amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew]
synonym: "proteinogenic amino acid anabolism" EXACT []
synonym: "proteinogenic amino acid biosynthesis" EXACT []
synonym: "proteinogenic amino acid formation" EXACT []
synonym: "proteinogenic amino acid synthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:83813 ! has primary output proteinogenic amino acid
relationship: RO:0004008 CHEBI:83813 ! has primary output proteinogenic amino acid
created_by: ew
creation_date: 2023-12-18T16:28:19Z

[Term]
id: GO:0170039
name: proteinogenic amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew]
synonym: "proteinogenic amino acid metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:83813 ! has primary input or output proteinogenic amino acid
relationship: RO:0004007 CHEBI:83813 ! has primary input or output proteinogenic amino acid
created_by: ew
creation_date: 2023-12-18T17:31:08Z

[Term]
id: GO:0170040
name: proteinogenic amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein." [GOC:ew]
synonym: "proteinogenic amino acid breakdown" EXACT []
synonym: "proteinogenic amino acid catabolism" EXACT []
synonym: "proteinogenic amino acid degradation" EXACT []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:83813 ! has primary input proteinogenic amino acid
relationship: RO:0004009 CHEBI:83813 ! has primary input proteinogenic amino acid
creation_date: 2023-12-18T17:41:14Z

[Term]
id: GO:0170041
name: non-proteinogenic amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-proteingenic amino acids." [GOC:ew]
synonym: "non-proteinogenic amino acid metabolism" EXACT []
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:83820 ! has primary input or output non-proteinogenic amino acid
relationship: RO:0004007 CHEBI:83820 ! has primary input or output non-proteinogenic amino acid
creation_date: 2023-12-18T17:57:55Z

[Term]
id: GO:0170043
name: non-proteinogenic amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of non-proteinogenic amino acids." [GOC:ew]
synonym: "non-proteinogenic amino acid anabolism" EXACT []
synonym: "non-proteinogenic amino acid formation" EXACT []
synonym: "non-proteinogenic amino acid synthesis" EXACT []
synonym: "non-proteinogenic biosynthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:83820 ! has primary output non-proteinogenic amino acid
relationship: RO:0004008 CHEBI:83820 ! has primary output non-proteinogenic amino acid
creation_date: 2023-12-18T19:03:08Z

[Term]
id: GO:0170044
name: non-proteinogenic amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-proteinogenic amino acids." [GOC:ew]
synonym: "non-proteinogenic amino acid breakdown" EXACT []
synonym: "non-proteinogenic amino acid catabolism" EXACT []
synonym: "non-proteinogenic amino acid degradation" EXACT []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:83820 ! has primary input non-proteinogenic amino acid
relationship: RO:0004009 CHEBI:83820 ! has primary input non-proteinogenic amino acid
creation_date: 2023-12-18T19:27:05Z

[Term]
id: GO:0170055
name: lipid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a lipid from one side of a membrane to the other." [GOC:curators]
subset: gocheck_do_not_annotate
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
creation_date: 2024-03-15T18:47:58Z

[Term]
id: GO:1900006
name: positive regulation of dendrite development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie]
synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0050773 ! regulation of dendrite development
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0016358 ! positively regulates dendrite development
relationship: RO:0002213 GO:0016358 ! positively regulates dendrite development
creation_date: 2012-01-09T10:41:31Z

[Term]
id: GO:1900015
name: regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002534 ! regulates cytokine production involved in inflammatory response
relationship: RO:0002211 GO:0002534 ! regulates cytokine production involved in inflammatory response
creation_date: 2012-01-11T09:34:27Z

[Term]
id: GO:1900016
name: negative regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002534 ! negatively regulates cytokine production involved in inflammatory response
relationship: RO:0002212 GO:0002534 ! negatively regulates cytokine production involved in inflammatory response
creation_date: 2012-01-11T09:34:31Z

[Term]
id: GO:1900017
name: positive regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002534 ! positively regulates cytokine production involved in inflammatory response
relationship: RO:0002213 GO:0002534 ! positively regulates cytokine production involved in inflammatory response
creation_date: 2012-01-11T09:34:35Z

[Term]
id: GO:1900115
name: extracellular regulation of signal transduction
namespace: biological_process
def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0009966 ! regulation of signal transduction
intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region
relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region
creation_date: 2012-02-22T10:21:48Z

[Term]
id: GO:1900116
name: extracellular negative regulation of signal transduction
namespace: biological_process
def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf]
synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie]
synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900115 ! extracellular regulation of signal transduction
intersection_of: GO:0009968 ! negative regulation of signal transduction
intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region
creation_date: 2012-02-22T10:27:56Z

[Term]
id: GO:1900117
name: regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis
relationship: RO:0002211 GO:0097194 ! regulates execution phase of apoptosis
creation_date: 2012-02-22T11:26:20Z

[Term]
id: GO:1900118
name: negative regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis
relationship: RO:0002212 GO:0097194 ! negatively regulates execution phase of apoptosis
creation_date: 2012-02-22T11:26:24Z

[Term]
id: GO:1900119
name: positive regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis
relationship: RO:0002213 GO:0097194 ! positively regulates execution phase of apoptosis
creation_date: 2012-02-22T11:26:27Z

[Term]
id: GO:1900120
name: regulation of receptor binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0043393 ! regulation of protein binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0005102 ! regulates signaling receptor binding
relationship: RO:0002211 GO:0005102 ! regulates signaling receptor binding
creation_date: 2012-02-22T11:40:53Z

[Term]
id: GO:1900121
name: negative regulation of receptor binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:1900120 ! regulation of receptor binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005102 ! negatively regulates signaling receptor binding
relationship: RO:0002212 GO:0005102 ! negatively regulates signaling receptor binding
creation_date: 2012-02-22T11:40:57Z

[Term]
id: GO:1900125
name: regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process
relationship: RO:0002211 GO:0030213 ! regulates hyaluronan biosynthetic process
creation_date: 2012-02-23T01:09:21Z

[Term]
id: GO:1900126
name: negative regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process
relationship: RO:0002212 GO:0030213 ! negatively regulates hyaluronan biosynthetic process
creation_date: 2012-02-23T01:09:29Z

[Term]
id: GO:1900127
name: positive regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process
relationship: RO:0002213 GO:0030213 ! positively regulates hyaluronan biosynthetic process
creation_date: 2012-02-23T01:09:33Z

[Term]
id: GO:1900131
name: negative regulation of lipid binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie]
is_a: GO:0051100 ! negative regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008289 ! negatively regulates lipid binding
relationship: RO:0002212 GO:0008289 ! negatively regulates lipid binding
creation_date: 2012-02-23T04:05:07Z

[Term]
id: GO:1900141
name: regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0034350 ! regulation of glial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097252 ! regulates oligodendrocyte apoptotic process
relationship: RO:0002211 GO:0097252 ! regulates oligodendrocyte apoptotic process
creation_date: 2012-03-06T10:22:45Z

[Term]
id: GO:1900142
name: negative regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0034351 ! negative regulation of glial cell apoptotic process
is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097252 ! negatively regulates oligodendrocyte apoptotic process
relationship: RO:0002212 GO:0097252 ! negatively regulates oligodendrocyte apoptotic process
creation_date: 2012-03-06T10:22:50Z

[Term]
id: GO:1900143
name: positive regulation of oligodendrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034352 ! positive regulation of glial cell apoptotic process
is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097252 ! positively regulates oligodendrocyte apoptotic process
relationship: RO:0002213 GO:0097252 ! positively regulates oligodendrocyte apoptotic process
creation_date: 2012-03-06T10:22:54Z

[Term]
id: GO:1900147
name: regulation of Schwann cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0036135 ! regulates Schwann cell migration
relationship: RO:0002211 GO:0036135 ! regulates Schwann cell migration
creation_date: 2012-03-06T04:14:50Z

[Term]
id: GO:1900148
name: negative regulation of Schwann cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie]
is_a: GO:1900147 ! regulation of Schwann cell migration
is_a: GO:1903976 ! negative regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0036135 ! negatively regulates Schwann cell migration
relationship: RO:0002212 GO:0036135 ! negatively regulates Schwann cell migration
creation_date: 2012-03-06T04:14:55Z

[Term]
id: GO:1900149
name: positive regulation of Schwann cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie]
synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie]
is_a: GO:1900147 ! regulation of Schwann cell migration
is_a: GO:1903977 ! positive regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0036135 ! positively regulates Schwann cell migration
relationship: RO:0002213 GO:0036135 ! positively regulates Schwann cell migration
creation_date: 2012-03-06T04:14:58Z

[Term]
id: GO:1900150
name: regulation of defense response to fungus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006]
synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol]
synonym: "regulation of defense response to fungus, incompatible interaction" NARROW []
synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol]
synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol]
synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0050832 ! regulates defense response to fungus
relationship: RO:0002211 GO:0050832 ! regulates defense response to fungus
creation_date: 2012-03-06T10:00:16Z

[Term]
id: GO:1900160
name: plastid chromosome packaging
namespace: biological_process
def: "A process in which plastidial DNA and associated proteins organize into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370]
synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie]
synonym: "DNA organization in plastid" EXACT [GOC:TermGenie]
synonym: "plastid DNA packaging" EXACT []
synonym: "plastidial DNA packaging" EXACT [GOC:emb]
is_a: GO:0051276 ! chromosome organization
intersection_of: GO:0051276 ! chromosome organization
intersection_of: BFO:0000066 GO:0009536 ! occurs in plastid
relationship: BFO:0000066 GO:0009536 ! occurs in plastid
creation_date: 2012-03-08T10:51:50Z

[Term]
id: GO:1900180
name: regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034504 ! regulates protein localization to nucleus
relationship: RO:0002211 GO:0034504 ! regulates protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:44Z

[Term]
id: GO:1900181
name: negative regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus
relationship: RO:0002212 GO:0034504 ! negatively regulates protein localization to nucleus
creation_date: 2012-03-12T01:23:48Z

[Term]
id: GO:1900182
name: positive regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus
relationship: RO:0002213 GO:0034504 ! positively regulates protein localization to nucleus
creation_date: 2012-03-12T01:23:52Z

[Term]
id: GO:1900193
name: regulation of oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001556 ! regulates oocyte maturation
relationship: RO:0002211 GO:0001556 ! regulates oocyte maturation
creation_date: 2012-03-19T09:41:18Z

[Term]
id: GO:1900194
name: negative regulation of oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation
relationship: RO:0002212 GO:0001556 ! negatively regulates oocyte maturation
creation_date: 2012-03-19T09:41:27Z

[Term]
id: GO:1900195
name: positive regulation of oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001556 ! positively regulates oocyte maturation
relationship: RO:0002213 GO:0001556 ! positively regulates oocyte maturation
creation_date: 2012-03-19T09:41:35Z

[Term]
id: GO:1900247
name: regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
is_a: GO:0006448 ! regulation of translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002182 ! regulates cytoplasmic translational elongation
relationship: RO:0002211 GO:0002182 ! regulates cytoplasmic translational elongation
creation_date: 2012-04-03T05:07:02Z

[Term]
id: GO:1900248
name: negative regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
is_a: GO:2000766 ! negative regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002182 ! negatively regulates cytoplasmic translational elongation
relationship: RO:0002212 GO:0002182 ! negatively regulates cytoplasmic translational elongation
creation_date: 2012-04-03T05:07:14Z

[Term]
id: GO:1900249
name: positive regulation of cytoplasmic translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie]
synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1900247 ! regulation of cytoplasmic translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002182 ! positively regulates cytoplasmic translational elongation
relationship: RO:0002213 GO:0002182 ! positively regulates cytoplasmic translational elongation
creation_date: 2012-04-03T05:07:24Z

[Term]
id: GO:1900366
name: negative regulation of defense response to insect
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie]
synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "susceptibility to insect" RELATED []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:2000068 ! regulation of defense response to insect
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002213 ! negatively regulates defense response to insect
relationship: RO:0002212 GO:0002213 ! negatively regulates defense response to insect
creation_date: 2012-04-12T04:44:00Z

[Term]
id: GO:1900367
name: positive regulation of defense response to insect
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "activation of defense response to insect" NARROW [GOC:TermGenie]
synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:2000068 ! regulation of defense response to insect
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002213 ! positively regulates defense response to insect
relationship: RO:0002213 GO:0002213 ! positively regulates defense response to insect
creation_date: 2012-04-12T04:44:10Z

[Term]
id: GO:1900376
name: regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044550 ! regulates secondary metabolite biosynthetic process
relationship: RO:0002211 GO:0044550 ! regulates secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:23Z

[Term]
id: GO:1900407
name: regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0080135 ! regulation of cellular response to stress
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034599 ! regulates cellular response to oxidative stress
relationship: RO:0002211 GO:0034599 ! regulates cellular response to oxidative stress
creation_date: 2012-04-20T03:30:52Z

[Term]
id: GO:1900408
name: negative regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1902883 ! negative regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034599 ! negatively regulates cellular response to oxidative stress
relationship: RO:0002212 GO:0034599 ! negatively regulates cellular response to oxidative stress
creation_date: 2012-04-20T03:31:05Z

[Term]
id: GO:1900409
name: positive regulation of cellular response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie]
synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1900407 ! regulation of cellular response to oxidative stress
is_a: GO:1902884 ! positive regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034599 ! positively regulates cellular response to oxidative stress
relationship: RO:0002213 GO:0034599 ! positively regulates cellular response to oxidative stress
creation_date: 2012-04-20T03:31:16Z

[Term]
id: GO:1900449
name: regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007215 ! regulates glutamate receptor signaling pathway
relationship: RO:0002211 GO:0007215 ! regulates glutamate receptor signaling pathway
creation_date: 2012-04-27T03:45:43Z

[Term]
id: GO:1900450
name: negative regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007215 ! negatively regulates glutamate receptor signaling pathway
relationship: RO:0002212 GO:0007215 ! negatively regulates glutamate receptor signaling pathway
creation_date: 2012-04-27T03:45:53Z

[Term]
id: GO:1900451
name: positive regulation of glutamate receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie]
synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007215 ! positively regulates glutamate receptor signaling pathway
relationship: RO:0002213 GO:0007215 ! positively regulates glutamate receptor signaling pathway
creation_date: 2012-04-27T03:46:03Z

[Term]
id: GO:1900923
name: regulation of glycine import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie]
synonym: "regulation of glycine import" BROAD []
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:0032890 ! regulation of organic acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1903804 ! regulates glycine import across plasma membrane
relationship: RO:0002211 GO:1903804 ! regulates glycine import across plasma membrane
creation_date: 2012-06-13T07:40:11Z

[Term]
id: GO:1900924
name: negative regulation of glycine import across plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie]
synonym: "down regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine import" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine import" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycine import" BROAD []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1903804 ! negatively regulates glycine import across plasma membrane
relationship: RO:0002212 GO:1903804 ! negatively regulates glycine import across plasma membrane
creation_date: 2012-06-13T07:40:32Z

[Term]
id: GO:1900925
name: positive regulation of glycine import across plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie]
synonym: "activation of glycine import" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycine import" BROAD []
synonym: "up regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine import" EXACT [GOC:TermGenie]
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import across plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1903804 ! positively regulates glycine import across plasma membrane
relationship: RO:0002213 GO:1903804 ! positively regulates glycine import across plasma membrane
creation_date: 2012-06-13T07:40:40Z

[Term]
id: GO:1901031
name: regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "regulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000302 ! regulates response to reactive oxygen species
relationship: RO:0002211 GO:0000302 ! regulates response to reactive oxygen species
creation_date: 2012-06-20T07:47:06Z

[Term]
id: GO:1901032
name: negative regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie]
synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1902883 ! negative regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000302 ! negatively regulates response to reactive oxygen species
relationship: RO:0002212 GO:0000302 ! negatively regulates response to reactive oxygen species
creation_date: 2012-06-20T07:47:28Z

[Term]
id: GO:1901033
name: positive regulation of response to reactive oxygen species
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]
synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "activation of response to AOS" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie]
synonym: "activation of response to ROI" EXACT [GOC:TermGenie]
synonym: "activation of response to ROS" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie]
synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie]
synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1902884 ! positive regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000302 ! positively regulates response to reactive oxygen species
relationship: RO:0002213 GO:0000302 ! positively regulates response to reactive oxygen species
creation_date: 2012-06-20T07:47:35Z

[Term]
id: GO:1901135
name: carbohydrate derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]
subset: goslim_agr
subset: goslim_generic
subset: goslim_mouse
subset: goslim_prokaryote
synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:63299 ! has primary input or output carbohydrate derivative
relationship: RO:0004007 CHEBI:63299 ! has primary input or output carbohydrate derivative
creation_date: 2012-07-12T04:05:09Z

[Term]
id: GO:1901136
name: carbohydrate derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
creation_date: 2012-07-12T04:05:31Z

[Term]
id: GO:1901137
name: carbohydrate derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:63299 ! has primary output carbohydrate derivative
relationship: RO:0004008 CHEBI:63299 ! has primary output carbohydrate derivative
creation_date: 2012-07-12T04:05:39Z

[Term]
id: GO:1901148
name: gene expression involved in extracellular matrix organization
namespace: biological_process
def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558]
synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf]
synonym: "extracellular matrix protein production" RELATED [GOC:pg]
is_a: GO:0010467 ! gene expression
intersection_of: GO:0010467 ! gene expression
intersection_of: BFO:0000050 GO:0030198 ! part of extracellular matrix organization
relationship: BFO:0000050 GO:0030198 ! part of extracellular matrix organization
creation_date: 2012-07-16T03:29:30Z

[Term]
id: GO:1901161
name: primary amino compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie]
synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound degradation" EXACT [GOC:TermGenie]
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:50994 ! has primary input primary amino compound
relationship: RO:0004009 CHEBI:50994 ! has primary input primary amino compound
creation_date: 2012-07-18T04:45:06Z

[Term]
id: GO:1901162
name: primary amino compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "primary amino compound formation" EXACT [GOC:TermGenie]
synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:50994 ! has primary output primary amino compound
relationship: RO:0004008 CHEBI:50994 ! has primary output primary amino compound
creation_date: 2012-07-18T04:45:14Z

[Term]
id: GO:1901163
name: regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061450 ! regulates trophoblast cell migration
relationship: RO:0002211 GO:0061450 ! regulates trophoblast cell migration
creation_date: 2012-07-19T07:53:06Z

[Term]
id: GO:1901164
name: negative regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061450 ! negatively regulates trophoblast cell migration
relationship: RO:0002212 GO:0061450 ! negatively regulates trophoblast cell migration
creation_date: 2012-07-19T07:53:28Z

[Term]
id: GO:1901165
name: positive regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061450 ! positively regulates trophoblast cell migration
relationship: RO:0002213 GO:0061450 ! positively regulates trophoblast cell migration
creation_date: 2012-07-19T07:53:35Z

[Term]
id: GO:1901166
name: neural crest cell migration involved in autonomic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie]
is_a: GO:0001755 ! neural crest cell migration
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: BFO:0000050 GO:0048483 ! part of autonomic nervous system development
relationship: BFO:0000050 GO:0048483 ! part of autonomic nervous system development
creation_date: 2012-07-19T08:39:56Z

[Term]
id: GO:1901190
name: regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex
relationship: RO:0002211 GO:0001677 ! regulates formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:26:58Z

[Term]
id: GO:1901191
name: negative regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex
relationship: RO:0002212 GO:0001677 ! negatively regulates formation of translation initiation ternary complex
creation_date: 2012-07-25T02:27:21Z

[Term]
id: GO:1901192
name: positive regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex
relationship: RO:0002213 GO:0001677 ! positively regulates formation of translation initiation ternary complex
creation_date: 2012-07-25T02:27:29Z

[Term]
id: GO:1901201
name: regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly
relationship: RO:0002211 GO:0085029 ! regulates extracellular matrix assembly
creation_date: 2012-07-27T04:04:00Z

[Term]
id: GO:1901202
name: negative regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie]
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly
relationship: RO:0002212 GO:0085029 ! negatively regulates extracellular matrix assembly
creation_date: 2012-07-27T04:04:24Z

[Term]
id: GO:1901203
name: positive regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly
relationship: RO:0002213 GO:0085029 ! positively regulates extracellular matrix assembly
creation_date: 2012-07-27T04:04:32Z

[Term]
id: GO:1901210
name: regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003207 ! regulates cardiac chamber formation
relationship: RO:0002211 GO:0003207 ! regulates cardiac chamber formation
creation_date: 2012-07-31T07:18:35Z

[Term]
id: GO:1901211
name: negative regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901210 ! regulation of cardiac chamber formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation
relationship: RO:0002212 GO:0003207 ! negatively regulates cardiac chamber formation
creation_date: 2012-07-31T07:18:57Z

[Term]
id: GO:1901212
name: positive regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:1901210 ! regulation of cardiac chamber formation
is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation
relationship: RO:0002213 GO:0003207 ! positively regulates cardiac chamber formation
creation_date: 2012-07-31T07:19:05Z

[Term]
id: GO:1901219
name: regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis
relationship: RO:0002211 GO:0003206 ! regulates cardiac chamber morphogenesis
creation_date: 2012-08-06T17:59:11Z

[Term]
id: GO:1901220
name: negative regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis
relationship: RO:0002212 GO:0003206 ! negatively regulates cardiac chamber morphogenesis
creation_date: 2012-08-06T17:59:34Z

[Term]
id: GO:1901221
name: positive regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis
relationship: RO:0002213 GO:0003206 ! positively regulates cardiac chamber morphogenesis
creation_date: 2012-08-06T17:59:42Z

[Term]
id: GO:1901264
name: carbohydrate derivative transport
namespace: biological_process
def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
creation_date: 2012-08-16T14:51:22Z

[Term]
id: GO:1901338
name: catecholamine binding
namespace: molecular_function
def: "Binding to catecholamine." [GOC:TermGenie]
is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:33567 ! has primary input
relationship: RO:0004009 CHEBI:33567 ! has primary input
creation_date: 2012-09-03T14:08:44Z

[Term]
id: GO:1901342
name: regulation of vasculature development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001944 ! regulates vasculature development
relationship: RO:0002211 GO:0001944 ! regulates vasculature development
creation_date: 2012-09-06T09:16:15Z

[Term]
id: GO:1901343
name: negative regulation of vasculature development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie]
synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001944 ! negatively regulates vasculature development
relationship: RO:0002212 GO:0001944 ! negatively regulates vasculature development
creation_date: 2012-09-06T09:17:24Z

[Term]
id: GO:1901363
name: heterocyclic compound binding
namespace: molecular_function
def: "Binding to heterocyclic compound." [GOC:TermGenie]
is_a: GO:0036094 ! small molecule binding
intersection_of: GO:0036094 ! small molecule binding
intersection_of: RO:0004009 CHEBI:5686 ! has primary input heterocyclic compound
relationship: RO:0004009 CHEBI:5686 ! has primary input heterocyclic compound
creation_date: 2012-09-14T13:53:50Z

[Term]
id: GO:1901374
name: acetate ester transport
namespace: biological_process
def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:47622 ! has primary input
relationship: RO:0004009 CHEBI:47622 ! has primary input
creation_date: 2012-09-28T10:42:13Z

[Term]
id: GO:1901375
name: acetate ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:47622 ! has primary input
relationship: BFO:0000050 GO:1901374 ! part of acetate ester transport
relationship: RO:0004009 CHEBI:47622 ! has primary input
creation_date: 2012-09-28T10:47:08Z

[Term]
id: GO:1901503
name: ether biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie]
synonym: "ether anabolism" EXACT [GOC:TermGenie]
synonym: "ether biosynthesis" EXACT [GOC:TermGenie]
synonym: "ether formation" EXACT [GOC:TermGenie]
synonym: "ether synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009058 ! biosynthetic process
created_by: pr
creation_date: 2012-10-17T09:42:47Z

[Term]
id: GO:1901505
name: carbohydrate derivative transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "carbohydrate derivative transporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
relationship: BFO:0000050 GO:1901264 ! part of carbohydrate derivative transport
relationship: RO:0004009 CHEBI:63299 ! has primary input carbohydrate derivative
creation_date: 2012-10-17T10:31:22Z

[Term]
id: GO:1901509
name: regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis
relationship: RO:0002211 GO:0061154 ! regulates endothelial tube morphogenesis
creation_date: 2012-10-17T14:30:40Z

[Term]
id: GO:1901532
name: regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation
relationship: RO:0002211 GO:0002244 ! regulates hematopoietic progenitor cell differentiation
creation_date: 2012-10-24T11:23:01Z

[Term]
id: GO:1901533
name: negative regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation
relationship: RO:0002212 GO:0002244 ! negatively regulates hematopoietic progenitor cell differentiation
creation_date: 2012-10-24T11:23:06Z

[Term]
id: GO:1901534
name: positive regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT []
synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation
relationship: RO:0002213 GO:0002244 ! positively regulates hematopoietic progenitor cell differentiation
creation_date: 2012-10-24T11:23:14Z

[Term]
id: GO:1901550
name: regulation of endothelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001885 ! regulates endothelial cell development
relationship: RO:0002211 GO:0001885 ! regulates endothelial cell development
creation_date: 2012-10-30T12:59:50Z

[Term]
id: GO:1901551
name: negative regulation of endothelial cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development
relationship: RO:0002212 GO:0001885 ! negatively regulates endothelial cell development
creation_date: 2012-10-30T12:59:54Z

[Term]
id: GO:1901552
name: positive regulation of endothelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001885 ! positively regulates endothelial cell development
relationship: RO:0002213 GO:0001885 ! positively regulates endothelial cell development
creation_date: 2012-10-30T12:59:58Z

[Term]
id: GO:1901588
name: dendritic microtubule
namespace: cellular_component
def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650]
synonym: "microtubule of dendrite" EXACT [GOC:TermGenie]
synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie]
xref: NIF_Subcellular:sao110773650
is_a: GO:0005874 ! microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: BFO:0000050 GO:0030425 ! part of dendrite
relationship: BFO:0000050 GO:0030425 ! part of dendrite
creation_date: 2012-11-07T14:37:30Z

[Term]
id: GO:1901589
name: axon microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678]
synonym: "axon microtubule fascicle" EXACT []
synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie]
synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie]
xref: NIF_Subcellular:sao707332678
is_a: GO:0097427 ! microtubule bundle
intersection_of: GO:0097427 ! microtubule bundle
intersection_of: BFO:0000050 GO:0030424 ! part of axon
relationship: BFO:0000050 GO:0030424 ! part of axon
creation_date: 2012-11-07T15:37:12Z

[Term]
id: GO:1901605
name: alpha-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino-acid zwitterion
relationship: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino-acid zwitterion
created_by: tb
creation_date: 2012-11-08T17:39:50Z

[Term]
id: GO:1901606
name: alpha-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:78608 ! has primary input alpha-amino-acid zwitterion
relationship: RO:0004009 CHEBI:78608 ! has primary input alpha-amino-acid zwitterion
creation_date: 2012-11-08T17:39:54Z

[Term]
id: GO:1901607
name: alpha-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:78608 ! has primary output alpha-amino-acid zwitterion
relationship: RO:0004008 CHEBI:78608 ! has primary output alpha-amino-acid zwitterion
created_by: tb
creation_date: 2012-11-08T17:39:58Z

[Term]
id: GO:1901608
name: regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule
relationship: RO:0002211 GO:0047496 ! regulates vesicle transport along microtubule
creation_date: 2012-11-08T21:49:44Z

[Term]
id: GO:1901609
name: negative regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule
relationship: RO:0002212 GO:0047496 ! negatively regulates vesicle transport along microtubule
creation_date: 2012-11-08T21:49:48Z

[Term]
id: GO:1901610
name: positive regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule
relationship: RO:0002213 GO:0047496 ! positively regulates vesicle transport along microtubule
creation_date: 2012-11-08T21:49:53Z

[Term]
id: GO:1901623
name: regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048247 ! regulates lymphocyte chemotaxis
relationship: RO:0002211 GO:0048247 ! regulates lymphocyte chemotaxis
creation_date: 2012-11-13T23:03:23Z

[Term]
id: GO:1901624
name: negative regulation of lymphocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie]
synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:1901623 ! regulation of lymphocyte chemotaxis
is_a: GO:2000402 ! negative regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048247 ! negatively regulates lymphocyte chemotaxis
relationship: RO:0002212 GO:0048247 ! negatively regulates lymphocyte chemotaxis
creation_date: 2012-11-13T23:03:28Z

[Term]
id: GO:1901626
name: regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "regulation of post-synaptic membrane organization" EXACT []
synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001941 ! regulates postsynaptic membrane organization
relationship: RO:0002211 GO:0001941 ! regulates postsynaptic membrane organization
creation_date: 2012-11-15T11:40:15Z

[Term]
id: GO:1901627
name: negative regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of post-synaptic membrane organization" EXACT []
synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001941 ! negatively regulates postsynaptic membrane organization
relationship: RO:0002212 GO:0001941 ! negatively regulates postsynaptic membrane organization
creation_date: 2012-11-15T11:40:20Z

[Term]
id: GO:1901628
name: positive regulation of postsynaptic membrane organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000]
synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie]
synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of post-synaptic membrane organization" EXACT []
synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901626 ! regulation of postsynaptic membrane organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001941 ! positively regulates postsynaptic membrane organization
relationship: RO:0002213 GO:0001941 ! positively regulates postsynaptic membrane organization
creation_date: 2012-11-15T11:40:24Z

[Term]
id: GO:1901652
name: response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
creation_date: 2012-11-20T09:45:15Z

[Term]
id: GO:1901653
name: cellular response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901652 ! response to peptide
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
creation_date: 2012-11-20T09:45:19Z

[Term]
id: GO:1901692
name: regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process
relationship: RO:0002211 GO:1990010 ! regulates compound eye retinal cell apoptotic process
creation_date: 2012-12-12T10:28:35Z

[Term]
id: GO:1901693
name: negative regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process
relationship: RO:0002212 GO:1990010 ! negatively regulates compound eye retinal cell apoptotic process
creation_date: 2012-12-12T10:28:40Z

[Term]
id: GO:1901694
name: positive regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "induction of compound eye retinal cell programmed cell death" RELATED []
synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process
relationship: RO:0002213 GO:1990010 ! positively regulates compound eye retinal cell apoptotic process
creation_date: 2012-12-12T10:28:45Z

[Term]
id: GO:1901698
name: response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to nitrogen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
creation_date: 2012-12-13T15:06:08Z

[Term]
id: GO:1901699
name: cellular response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "cellular response to nitrogen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
creation_date: 2012-12-13T15:06:13Z

[Term]
id: GO:1901700
name: response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_annotate
synonym: "response to oxygen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity
relationship: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity
creation_date: 2012-12-13T15:11:37Z

[Term]
id: GO:1901701
name: cellular response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "cellular response to oxygen molecular entity" EXACT []
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:25806 ! has primary input oxygen molecular entity
creation_date: 2012-12-13T15:11:42Z

[Term]
id: GO:1901706
name: mesenchymal cell differentiation involved in bone development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: BFO:0000050 GO:0060348 ! part of bone development
relationship: BFO:0000050 GO:0060348 ! part of bone development
creation_date: 2012-12-14T16:04:16Z

[Term]
id: GO:1901715
name: regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009450 ! regulates gamma-aminobutyric acid catabolic process
relationship: RO:0002211 GO:0009450 ! regulates gamma-aminobutyric acid catabolic process
creation_date: 2012-12-19T16:13:24Z

[Term]
id: GO:1901716
name: negative regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009450 ! negatively regulates gamma-aminobutyric acid catabolic process
relationship: RO:0002212 GO:0009450 ! negatively regulates gamma-aminobutyric acid catabolic process
creation_date: 2012-12-19T16:13:31Z

[Term]
id: GO:1901717
name: positive regulation of gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie]
synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009450 ! positively regulates gamma-aminobutyric acid catabolic process
relationship: RO:0002213 GO:0009450 ! positively regulates gamma-aminobutyric acid catabolic process
creation_date: 2012-12-19T16:13:36Z

[Term]
id: GO:1901858
name: regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032042 ! regulates mitochondrial DNA metabolic process
relationship: RO:0002211 GO:0032042 ! regulates mitochondrial DNA metabolic process
creation_date: 2013-02-01T10:05:04Z

[Term]
id: GO:1901859
name: negative regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032042 ! negatively regulates mitochondrial DNA metabolic process
relationship: RO:0002212 GO:0032042 ! negatively regulates mitochondrial DNA metabolic process
creation_date: 2013-02-01T10:05:09Z

[Term]
id: GO:1901860
name: positive regulation of mitochondrial DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032042 ! positively regulates mitochondrial DNA metabolic process
relationship: RO:0002213 GO:0007005 ! positively regulates mitochondrion organization
relationship: RO:0002213 GO:0032042 ! positively regulates mitochondrial DNA metabolic process
creation_date: 2013-02-01T10:05:14Z

[Term]
id: GO:1901861
name: regulation of muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060537 ! regulates muscle tissue development
relationship: RO:0002211 GO:0060537 ! regulates muscle tissue development
creation_date: 2013-02-01T10:30:47Z

[Term]
id: GO:1901862
name: negative regulation of muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development
relationship: RO:0002212 GO:0060537 ! negatively regulates muscle tissue development
creation_date: 2013-02-01T10:30:52Z

[Term]
id: GO:1901863
name: positive regulation of muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060537 ! positively regulates muscle tissue development
relationship: RO:0002213 GO:0060537 ! positively regulates muscle tissue development
creation_date: 2013-02-01T10:30:57Z

[Term]
id: GO:1901879
name: regulation of protein depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051261 ! regulates protein depolymerization
relationship: RO:0002211 GO:0051261 ! regulates protein depolymerization
creation_date: 2013-02-06T13:57:23Z

[Term]
id: GO:1901880
name: negative regulation of protein depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization
relationship: RO:0002212 GO:0051261 ! negatively regulates protein depolymerization
creation_date: 2013-02-06T13:57:28Z

[Term]
id: GO:1901881
name: positive regulation of protein depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051261 ! positively regulates protein depolymerization
relationship: RO:0002213 GO:0051261 ! positively regulates protein depolymerization
creation_date: 2013-02-06T13:57:32Z

[Term]
id: GO:1901888
name: regulation of cell junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0034329 ! regulates cell junction assembly
relationship: RO:0002211 GO:0034329 ! regulates cell junction assembly
creation_date: 2013-02-06T19:40:32Z

[Term]
id: GO:1901889
name: negative regulation of cell junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly
relationship: RO:0002212 GO:0034329 ! negatively regulates cell junction assembly
creation_date: 2013-02-06T19:40:41Z

[Term]
id: GO:1901890
name: positive regulation of cell junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034329 ! positively regulates cell junction assembly
relationship: RO:0002213 GO:0034329 ! positively regulates cell junction assembly
creation_date: 2013-02-06T19:40:46Z

[Term]
id: GO:1901950
name: dense core granule transport
namespace: biological_process
def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451]
comment: goslim_synapse
synonym: "dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0016482 ! cytosolic transport
is_a: GO:0032253 ! dense core granule localization
is_a: GO:0051650 ! establishment of vesicle localization
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
intersection_of: RO:0004009 GO:0031045 ! has primary input dense core granule
creation_date: 2013-02-19T13:00:52Z

[Term]
id: GO:1901951
name: regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1904809 ! regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990048 ! regulates anterograde neuronal dense core vesicle transport
relationship: RO:0002211 GO:1990048 ! regulates anterograde neuronal dense core vesicle transport
creation_date: 2013-02-19T13:36:21Z

[Term]
id: GO:1901952
name: negative regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1901951 ! regulation of anterograde dense core granule transport
is_a: GO:1904810 ! negative regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990048 ! negatively regulates anterograde neuronal dense core vesicle transport
relationship: RO:0002212 GO:1990048 ! negatively regulates anterograde neuronal dense core vesicle transport
creation_date: 2013-02-19T13:36:30Z

[Term]
id: GO:1901953
name: positive regulation of anterograde dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie]
synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1901951 ! regulation of anterograde dense core granule transport
is_a: GO:1904811 ! positive regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990048 ! positively regulates anterograde neuronal dense core vesicle transport
relationship: RO:0002213 GO:1990048 ! positively regulates anterograde neuronal dense core vesicle transport
creation_date: 2013-02-19T13:36:35Z

[Term]
id: GO:1901954
name: regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
is_a: GO:1904809 ! regulation of dense core granule transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990049 ! regulates retrograde neuronal dense core vesicle transport
relationship: RO:0002211 GO:1990049 ! regulates retrograde neuronal dense core vesicle transport
creation_date: 2013-02-19T13:36:43Z

[Term]
id: GO:1901955
name: negative regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie]
is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule
is_a: GO:1901954 ! regulation of retrograde dense core granule transport
is_a: GO:1904810 ! negative regulation of dense core granule transport
is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990049 ! negatively regulates retrograde neuronal dense core vesicle transport
relationship: RO:0002212 GO:1990049 ! negatively regulates retrograde neuronal dense core vesicle transport
creation_date: 2013-02-19T13:36:47Z

[Term]
id: GO:1901956
name: positive regulation of retrograde dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451]
synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie]
synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie]
is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule
is_a: GO:1901954 ! regulation of retrograde dense core granule transport
is_a: GO:1904811 ! positive regulation of dense core granule transport
is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990049 ! positively regulates retrograde neuronal dense core vesicle transport
relationship: RO:0002213 GO:1990049 ! positively regulates retrograde neuronal dense core vesicle transport
creation_date: 2013-02-19T13:36:52Z

[Term]
id: GO:1901963
name: regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis
relationship: RO:0002211 GO:0061325 ! regulates cell proliferation involved in outflow tract morphogenesis
creation_date: 2013-02-20T20:30:26Z

[Term]
id: GO:1901964
name: positive regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis
relationship: RO:0002213 GO:0061325 ! positively regulates cell proliferation involved in outflow tract morphogenesis
creation_date: 2013-02-20T20:30:31Z

[Term]
id: GO:1902017
name: regulation of cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060271 ! regulates cilium assembly
relationship: RO:0002211 GO:0060271 ! regulates cilium assembly
creation_date: 2013-03-26T18:10:51Z

[Term]
id: GO:1902018
name: negative regulation of cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060271 ! negatively regulates cilium assembly
relationship: RO:0002212 GO:0060271 ! negatively regulates cilium assembly
creation_date: 2013-03-26T18:10:56Z

[Term]
id: GO:1902019
name: regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "regulation of ciliary cell motility" RELATED []
synonym: "regulation of cilium cell motility" EXACT []
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060285 ! regulates cilium-dependent cell motility
relationship: RO:0002211 GO:0060285 ! regulates cilium-dependent cell motility
creation_date: 2013-03-27T14:42:38Z

[Term]
id: GO:1902020
name: negative regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie]
synonym: "negative regulation of ciliary cell motility" RELATED []
synonym: "negative regulation of cilium cell motility" EXACT []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060285 ! negatively regulates cilium-dependent cell motility
relationship: RO:0002212 GO:0060285 ! negatively regulates cilium-dependent cell motility
creation_date: 2013-03-27T14:42:42Z

[Term]
id: GO:1902033
name: regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation
relationship: RO:0002211 GO:0071425 ! regulates hematopoietic stem cell proliferation
creation_date: 2013-04-02T05:13:19Z

[Term]
id: GO:1902034
name: negative regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:1903707 ! negative regulation of hemopoiesis
is_a: GO:2000647 ! negative regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation
relationship: RO:0002212 GO:0071425 ! negatively regulates hematopoietic stem cell proliferation
creation_date: 2013-04-02T05:13:24Z

[Term]
id: GO:1902035
name: positive regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation
relationship: RO:0002213 GO:0071425 ! positively regulates hematopoietic stem cell proliferation
creation_date: 2013-04-02T05:13:31Z

[Term]
id: GO:1902036
name: regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
xref: Reactome:R-HSA-8939236 "RUNX1 regulates transcription of genes involved in differentiation of HSCs"
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation
relationship: RO:0002211 GO:0060218 ! regulates hematopoietic stem cell differentiation
creation_date: 2013-04-02T05:19:09Z

[Term]
id: GO:1902037
name: negative regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation
relationship: RO:0002212 GO:0060218 ! negatively regulates hematopoietic stem cell differentiation
creation_date: 2013-04-02T05:19:14Z

[Term]
id: GO:1902038
name: positive regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation
relationship: RO:0002213 GO:0060218 ! positively regulates hematopoietic stem cell differentiation
creation_date: 2013-04-02T05:19:19Z

[Term]
id: GO:1902065
name: response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009]
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
relationship: RO:0004009 CHEBI:29985 ! has primary input
creation_date: 2013-04-16T21:21:14Z

[Term]
id: GO:1902105
name: regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002521 ! regulates leukocyte differentiation
relationship: RO:0002211 GO:0002521 ! regulates leukocyte differentiation
creation_date: 2013-05-02T17:32:42Z

[Term]
id: GO:1902106
name: negative regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903707 ! negative regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation
relationship: RO:0002212 GO:0002521 ! negatively regulates leukocyte differentiation
creation_date: 2013-05-02T17:32:47Z

[Term]
id: GO:1902107
name: positive regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation
relationship: RO:0002213 GO:0002521 ! positively regulates leukocyte differentiation
creation_date: 2013-05-02T17:32:52Z

[Term]
id: GO:1902115
name: regulation of organelle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070925 ! regulates organelle assembly
relationship: RO:0002211 GO:0070925 ! regulates organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:21Z

[Term]
id: GO:1902116
name: negative regulation of organelle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070925 ! negatively regulates organelle assembly
relationship: RO:0002212 GO:0070925 ! negatively regulates organelle assembly
creation_date: 2013-05-14T09:43:31Z

[Term]
id: GO:1902117
name: positive regulation of organelle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "activation of organelle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070925 ! positively regulates organelle assembly
relationship: RO:0002213 GO:0070925 ! positively regulates organelle assembly
creation_date: 2013-05-14T09:43:36Z

[Term]
id: GO:1902211
name: regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0038161 ! regulates prolactin signaling pathway
relationship: RO:0002211 GO:0038161 ! regulates prolactin signaling pathway
creation_date: 2013-06-12T10:10:07Z

[Term]
id: GO:1902212
name: negative regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:1902211 ! regulation of prolactin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0038161 ! negatively regulates prolactin signaling pathway
relationship: RO:0002212 GO:0038161 ! negatively regulates prolactin signaling pathway
creation_date: 2013-06-12T10:10:12Z

[Term]
id: GO:1902213
name: positive regulation of prolactin signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439]
synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie]
synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:1902211 ! regulation of prolactin signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0038161 ! positively regulates prolactin signaling pathway
relationship: RO:0002213 GO:0038161 ! positively regulates prolactin signaling pathway
creation_date: 2013-06-12T10:10:18Z

[Term]
id: GO:1902217
name: erythrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033028 ! myeloid cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000232 ! occurs in erythrocyte
relationship: BFO:0000066 CL:0000232 ! occurs in erythrocyte
creation_date: 2013-06-13T10:02:29Z

[Term]
id: GO:1902250
name: regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process
relationship: RO:0002211 GO:1902217 ! regulates erythrocyte apoptotic process
creation_date: 2013-06-20T19:30:53Z

[Term]
id: GO:1902251
name: negative regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process
relationship: RO:0002212 GO:1902217 ! negatively regulates erythrocyte apoptotic process
creation_date: 2013-06-20T19:30:59Z

[Term]
id: GO:1902252
name: positive regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process
relationship: RO:0002213 GO:1902217 ! positively regulates erythrocyte apoptotic process
creation_date: 2013-06-20T19:31:04Z

[Term]
id: GO:1902256
name: regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis
relationship: RO:0002211 GO:0003275 ! regulates apoptotic process involved in outflow tract morphogenesis
creation_date: 2013-06-24T19:12:24Z

[Term]
id: GO:1902257
name: negative regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis
relationship: RO:0002212 GO:0003275 ! negatively regulates apoptotic process involved in outflow tract morphogenesis
creation_date: 2013-06-24T19:12:30Z

[Term]
id: GO:1902258
name: positive regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis
relationship: RO:0002213 GO:0003275 ! positively regulates apoptotic process involved in outflow tract morphogenesis
creation_date: 2013-06-24T19:12:42Z

[Term]
id: GO:1902262
name: apoptotic process involved in blood vessel morphogenesis
namespace: biological_process
def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358]
synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis
relationship: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis
creation_date: 2013-06-25T16:16:00Z

[Term]
id: GO:1902275
name: regulation of chromatin organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]
synonym: "regulation of chromatin assembly or disassembly" RELATED []
synonym: "regulation of chromatin assembly/disassembly" RELATED []
synonym: "regulation of chromatin modification" RELATED []
synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006325 ! regulates chromatin organization
relationship: RO:0002211 GO:0006325 ! regulates chromatin organization
creation_date: 2013-07-01T13:21:52Z

[Term]
id: GO:1902337
name: regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis
relationship: RO:0002211 GO:0060561 ! regulates apoptotic process involved in morphogenesis
creation_date: 2013-07-29T15:03:16Z

[Term]
id: GO:1902338
name: negative regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis
relationship: RO:0002212 GO:0060561 ! negatively regulates apoptotic process involved in morphogenesis
creation_date: 2013-07-29T15:03:25Z

[Term]
id: GO:1902339
name: positive regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis
relationship: RO:0002213 GO:0060561 ! positively regulates apoptotic process involved in morphogenesis
creation_date: 2013-07-29T15:03:33Z

[Term]
id: GO:1902340
name: negative regulation of chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725]
synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation
relationship: RO:0002212 GO:0030261 ! negatively regulates chromosome condensation
creation_date: 2013-07-29T20:54:14Z

[Term]
id: GO:1902369
name: negative regulation of RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]
synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process
relationship: RO:0002212 GO:0006401 ! negatively regulates RNA catabolic process
creation_date: 2013-08-22T14:59:39Z

[Term]
id: GO:1902396
name: protein localization to bicellular tight junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie]
synonym: "protein localization in tight junction" EXACT [GOC:TermGenie]
is_a: GO:0150105 ! protein localization to cell-cell junction
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005923 ! has target end location bicellular tight junction
relationship: RO:0002339 GO:0005923 ! has target end location bicellular tight junction
creation_date: 2013-09-11T21:43:13Z

[Term]
id: GO:1902414
name: protein localization to cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie]
synonym: "protein localization in cell junction" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0030054 ! has target end location cell junction
relationship: RO:0002339 GO:0030054 ! has target end location cell junction
creation_date: 2013-09-13T16:55:57Z

[Term]
id: GO:1902463
name: protein localization to cell leading edge
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326]
synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0031252 ! has target end location cell leading edge
relationship: RO:0002339 GO:0031252 ! has target end location cell leading edge
creation_date: 2013-10-22T12:36:07Z

[Term]
id: GO:1902473
name: regulation of protein localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035418 ! regulates protein localization to synapse
relationship: RO:0002211 GO:0035418 ! regulates protein localization to synapse
creation_date: 2013-10-25T15:09:09Z

[Term]
id: GO:1902474
name: positive regulation of protein localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse
relationship: RO:0002213 GO:0035418 ! positively regulates protein localization to synapse
creation_date: 2013-10-25T15:09:18Z

[Term]
id: GO:1902475
name: L-alpha-amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347]
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
creation_date: 2013-10-25T15:17:39Z

[Term]
id: GO:1902494
name: catalytic complex
namespace: cellular_component
def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]
subset: goslim_metagenomics
synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl]
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0003824 ! capable of catalytic activity
relationship: RO:0002215 GO:0003824 ! capable of catalytic activity
creation_date: 2013-11-13T16:18:47Z

[Term]
id: GO:1902495
name: transmembrane transporter complex
namespace: cellular_component
def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990351 ! transporter complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0022857 ! capable of transmembrane transporter activity
relationship: RO:0002215 GO:0022857 ! capable of transmembrane transporter activity
creation_date: 2013-11-13T16:23:04Z

[Term]
id: GO:1902510
name: regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie]
synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie]
synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006309 ! regulates apoptotic DNA fragmentation
relationship: RO:0002211 GO:0006309 ! regulates apoptotic DNA fragmentation
creation_date: 2013-11-15T18:28:32Z

[Term]
id: GO:1902511
name: negative regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903625 ! negative regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006309 ! negatively regulates apoptotic DNA fragmentation
relationship: RO:0002212 GO:0006309 ! negatively regulates apoptotic DNA fragmentation
creation_date: 2013-11-15T18:28:41Z

[Term]
id: GO:1902512
name: positive regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903626 ! positive regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006309 ! positively regulates apoptotic DNA fragmentation
relationship: RO:0002213 GO:0006309 ! positively regulates apoptotic DNA fragmentation
creation_date: 2013-11-15T18:28:50Z

[Term]
id: GO:1902513
name: regulation of organelle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087]
synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule
relationship: RO:0002211 GO:0072384 ! regulates organelle transport along microtubule
creation_date: 2013-11-15T20:15:17Z

[Term]
id: GO:1902531
name: regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010627
def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "regulation of intracellular protein kinase cascade" NARROW []
synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035556 ! regulates intracellular signal transduction
relationship: RO:0002211 GO:0035556 ! regulates intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:32:52Z

[Term]
id: GO:1902532
name: negative regulation of intracellular signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular protein kinase cascade" EXACT []
synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction
relationship: RO:0002212 GO:0035556 ! negatively regulates intracellular signal transduction
creation_date: 2013-12-02T11:33:01Z

[Term]
id: GO:1902533
name: positive regulation of intracellular signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular protein kinase cascade" NARROW []
synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction
relationship: RO:0002213 GO:0035556 ! positively regulates intracellular signal transduction
creation_date: 2013-12-02T11:33:10Z

[Term]
id: GO:1902570
name: protein localization to nucleolus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626]
synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005730 ! has target end location nucleolus
relationship: RO:0002339 GO:0005730 ! has target end location nucleolus
creation_date: 2013-12-10T16:25:28Z

[Term]
id: GO:1902652
name: secondary alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006066 ! alcohol metabolic process
created_by: tt
creation_date: 2014-01-22T10:14:52Z

[Term]
id: GO:1902653
name: secondary alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "secondary alcohol formation" EXACT [GOC:TermGenie]
synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: tt
creation_date: 2014-01-22T10:15:02Z

[Term]
id: GO:1902679
name: negative regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process
relationship: RO:0002212 GO:0032774 ! negatively regulates RNA biosynthetic process
creation_date: 2014-02-05T16:32:01Z

[Term]
id: GO:1902680
name: positive regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of RNA formation" NARROW [GOC:TermGenie]
synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process
relationship: RO:0002213 GO:0032774 ! positively regulates RNA biosynthetic process
creation_date: 2014-02-05T16:32:10Z

[Term]
id: GO:1902683
name: regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097120 ! regulates receptor localization to synapse
relationship: RO:0002211 GO:0097120 ! regulates receptor localization to synapse
creation_date: 2014-02-07T17:38:31Z

[Term]
id: GO:1902684
name: negative regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie]
synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie]
synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1902683 ! regulation of receptor localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097120 ! negatively regulates receptor localization to synapse
relationship: RO:0002212 GO:0097120 ! negatively regulates receptor localization to synapse
creation_date: 2014-02-07T17:38:41Z

[Term]
id: GO:1902685
name: positive regulation of receptor localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129]
synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1902683 ! regulation of receptor localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097120 ! positively regulates receptor localization to synapse
relationship: RO:0002213 GO:0097120 ! positively regulates receptor localization to synapse
creation_date: 2014-02-07T17:38:51Z

[Term]
id: GO:1902692
name: regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007405 ! regulates neuroblast proliferation
relationship: RO:0002211 GO:0007405 ! regulates neuroblast proliferation
creation_date: 2014-02-18T10:03:31Z

[Term]
id: GO:1902710
name: GABA receptor complex
namespace: cellular_component
def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
synonym: "gamma-aminobutyric acid receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0016917 ! capable of GABA receptor activity
relationship: RO:0002215 GO:0016917 ! capable of GABA receptor activity
creation_date: 2014-02-20T16:07:48Z

[Term]
id: GO:1902721
name: negative regulation of prolactin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie]
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070459 ! negatively regulates prolactin secretion
relationship: RO:0002212 GO:0070459 ! negatively regulates prolactin secretion
creation_date: 2014-02-24T16:09:28Z

[Term]
id: GO:1902722
name: positive regulation of prolactin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377]
synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie]
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070459 ! positively regulates prolactin secretion
relationship: RO:0002213 GO:0070459 ! positively regulates prolactin secretion
creation_date: 2014-02-24T16:09:37Z

[Term]
id: GO:1902738
name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:1903010 ! regulation of bone development
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: RO:0002211 GO:0003413 ! regulates chondrocyte differentiation involved in endochondral bone morphogenesis
creation_date: 2014-02-26T15:36:15Z

[Term]
id: GO:1902742
name: apoptotic process involved in development
namespace: biological_process
def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic process involved in anatomical structure development" EXACT []
synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000050 GO:0048856 ! part of anatomical structure development
relationship: BFO:0000050 GO:0048856 ! part of anatomical structure development
creation_date: 2014-02-28T13:09:43Z

[Term]
id: GO:1902761
name: positive regulation of chondrocyte development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie]
synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0032332 ! positive regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002063 ! positively regulates chondrocyte development
relationship: RO:0002213 GO:0002063 ! positively regulates chondrocyte development
creation_date: 2014-03-07T17:45:55Z

[Term]
id: GO:1902809
name: regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation
relationship: RO:0002211 GO:0098528 ! regulates skeletal muscle fiber differentiation
creation_date: 2014-03-26T21:18:26Z

[Term]
id: GO:1902810
name: negative regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
is_a: GO:0010832 ! negative regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation
relationship: RO:0002212 GO:0098528 ! negatively regulates skeletal muscle fiber differentiation
creation_date: 2014-03-26T21:18:32Z

[Term]
id: GO:1902811
name: positive regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
is_a: GO:0010831 ! positive regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation
relationship: RO:0002213 GO:0098528 ! positively regulates skeletal muscle fiber differentiation
creation_date: 2014-03-26T21:18:38Z

[Term]
id: GO:1902816
name: regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035372 ! regulates protein localization to microtubule
relationship: RO:0002211 GO:0035372 ! regulates protein localization to microtubule
creation_date: 2014-03-27T22:07:12Z

[Term]
id: GO:1902817
name: negative regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:1902816 ! regulation of protein localization to microtubule
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule
relationship: RO:0002212 GO:0035372 ! negatively regulates protein localization to microtubule
creation_date: 2014-03-27T22:07:18Z

[Term]
id: GO:1902838
name: regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie]
synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie]
synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule
relationship: RO:0002211 GO:0030473 ! regulates nuclear migration along microtubule
creation_date: 2014-04-01T13:50:23Z

[Term]
id: GO:1902839
name: negative regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule
relationship: RO:0002212 GO:0030473 ! negatively regulates nuclear migration along microtubule
creation_date: 2014-04-01T13:50:29Z

[Term]
id: GO:1902840
name: positive regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule
relationship: RO:0002213 GO:0030473 ! positively regulates nuclear migration along microtubule
creation_date: 2014-04-01T13:50:35Z

[Term]
id: GO:1902850
name: microtubule cytoskeleton organization involved in mitosis
namespace: biological_process
def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626]
synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie]
synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle
creation_date: 2014-04-02T14:19:38Z

[Term]
id: GO:1902863
name: regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development
relationship: RO:0002211 GO:0031076 ! regulates embryonic camera-type eye development
creation_date: 2014-04-03T15:24:00Z

[Term]
id: GO:1902864
name: negative regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development
relationship: RO:0002212 GO:0031076 ! negatively regulates embryonic camera-type eye development
creation_date: 2014-04-03T15:24:06Z

[Term]
id: GO:1902865
name: positive regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development
relationship: RO:0002213 GO:0031076 ! positively regulates embryonic camera-type eye development
creation_date: 2014-04-03T15:24:12Z

[Term]
id: GO:1902866
name: regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye
relationship: RO:0002211 GO:0060041 ! regulates retina development in camera-type eye
creation_date: 2014-04-03T15:24:17Z

[Term]
id: GO:1902867
name: negative regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retinal development" RELATED [GOC:TermGenie]
synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retinal development" RELATED [GOC:TermGenie]
synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye
relationship: RO:0002212 GO:0060041 ! negatively regulates retina development in camera-type eye
creation_date: 2014-04-03T15:24:23Z

[Term]
id: GO:1902868
name: positive regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "activation of retinal development" RELATED [GOC:TermGenie]
synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye
relationship: RO:0002213 GO:0060041 ! positively regulates retina development in camera-type eye
creation_date: 2014-04-03T15:24:29Z

[Term]
id: GO:1902875
name: regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie]
synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie]
synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009880 ! regulates embryonic pattern specification
relationship: RO:0002211 GO:0009880 ! regulates embryonic pattern specification
creation_date: 2014-04-03T15:25:15Z

[Term]
id: GO:1902876
name: negative regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902875 ! regulation of embryonic pattern specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009880 ! negatively regulates embryonic pattern specification
relationship: RO:0002212 GO:0009880 ! negatively regulates embryonic pattern specification
creation_date: 2014-04-03T15:25:20Z

[Term]
id: GO:1902877
name: positive regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902875 ! regulation of embryonic pattern specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009880 ! positively regulates embryonic pattern specification
relationship: RO:0002213 GO:0009880 ! positively regulates embryonic pattern specification
creation_date: 2014-04-03T15:25:26Z

[Term]
id: GO:1902882
name: regulation of response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006979 ! regulates response to oxidative stress
relationship: RO:0002211 GO:0006979 ! regulates response to oxidative stress
creation_date: 2014-04-03T20:29:52Z

[Term]
id: GO:1902883
name: negative regulation of response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006979 ! negatively regulates response to oxidative stress
relationship: RO:0002212 GO:0006979 ! negatively regulates response to oxidative stress
creation_date: 2014-04-03T20:30:20Z

[Term]
id: GO:1902884
name: positive regulation of response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554]
synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie]
synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie]
synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1902882 ! regulation of response to oxidative stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006979 ! positively regulates response to oxidative stress
relationship: RO:0002213 GO:0006979 ! positively regulates response to oxidative stress
creation_date: 2014-04-03T20:30:47Z

[Term]
id: GO:1902903
name: regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization
relationship: RO:0002211 GO:0097435 ! regulates supramolecular fiber organization
creation_date: 2014-04-15T16:46:36Z

[Term]
id: GO:1902904
name: negative regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization
relationship: RO:0002212 GO:0097435 ! negatively regulates supramolecular fiber organization
creation_date: 2014-04-15T16:46:42Z

[Term]
id: GO:1902905
name: positive regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "activation of fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of fibril organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization
relationship: RO:0002213 GO:0097435 ! positively regulates supramolecular fiber organization
creation_date: 2014-04-15T16:46:48Z

[Term]
id: GO:1902913
name: positive regulation of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506]
synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation
relationship: RO:0002213 GO:0060563 ! positively regulates neuroepithelial cell differentiation
creation_date: 2014-04-18T21:06:42Z

[Term]
id: GO:1902930
name: regulation of alcohol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010]
synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie]
synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of solventogenesis" BROAD []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046165 ! regulates alcohol biosynthetic process
relationship: RO:0002211 GO:0046165 ! regulates alcohol biosynthetic process
created_by: tt
creation_date: 2014-04-22T21:55:03Z

[Term]
id: GO:1903008
name: organelle disassembly
namespace: biological_process
def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]
synonym: "organelle degradation" EXACT []
is_a: GO:0006996 ! organelle organization
is_a: GO:0022411 ! cellular component disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0043226 ! results in disassembly of organelle
relationship: RO:0002590 GO:0043226 ! results in disassembly of organelle
created_by: jl
creation_date: 2014-05-13T12:36:03Z

[Term]
id: GO:1903010
name: regulation of bone development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060348 ! regulates bone development
relationship: RO:0002211 GO:0060348 ! regulates bone development
creation_date: 2014-05-13T22:41:53Z

[Term]
id: GO:1903011
name: negative regulation of bone development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "down regulation of bone development" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "downregulation of bone development" EXACT [GOC:TermGenie]
synonym: "inhibition of bone development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060348 ! negatively regulates bone development
relationship: RO:0002212 GO:0060348 ! negatively regulates bone development
creation_date: 2014-05-13T22:42:00Z

[Term]
id: GO:1903012
name: positive regulation of bone development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "activation of bone development" NARROW [GOC:TermGenie]
synonym: "up regulation of bone development" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "upregulation of bone development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060348 ! positively regulates bone development
relationship: RO:0002213 GO:0060348 ! positively regulates bone development
creation_date: 2014-05-13T22:42:06Z

[Term]
id: GO:1903018
name: regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process
relationship: RO:0002211 GO:0009100 ! regulates glycoprotein metabolic process
creation_date: 2014-05-14T18:44:19Z

[Term]
id: GO:1903019
name: negative regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051248 ! negative regulation of protein metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process
relationship: RO:0002212 GO:0009100 ! negatively regulates glycoprotein metabolic process
creation_date: 2014-05-14T18:44:25Z

[Term]
id: GO:1903020
name: positive regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051247 ! positive regulation of protein metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process
relationship: RO:0002213 GO:0009100 ! positively regulates glycoprotein metabolic process
creation_date: 2014-05-14T18:44:31Z

[Term]
id: GO:1903037
name: regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007159 ! regulates leukocyte cell-cell adhesion
relationship: RO:0002211 GO:0007159 ! regulates leukocyte cell-cell adhesion
creation_date: 2014-05-19T15:29:58Z

[Term]
id: GO:1903038
name: negative regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007159 ! negatively regulates leukocyte cell-cell adhesion
relationship: RO:0002212 GO:0007159 ! negatively regulates leukocyte cell-cell adhesion
creation_date: 2014-05-19T15:30:05Z

[Term]
id: GO:1903039
name: positive regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007159 ! positively regulates leukocyte cell-cell adhesion
relationship: RO:0002213 GO:0007159 ! positively regulates leukocyte cell-cell adhesion
creation_date: 2014-05-19T15:30:15Z

[Term]
id: GO:1903045
name: neural crest cell migration involved in sympathetic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129]
comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development
is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development
relationship: BFO:0000050 GO:0048485 ! part of sympathetic nervous system development
creation_date: 2014-05-22T07:06:02Z

[Term]
id: GO:1903046
name: meiotic cell cycle process
namespace: biological_process
def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
subset: goslim_pombe
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0009987 ! cellular process
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle
disjoint_from: GO:1903047 ! mitotic cell cycle process
relationship: BFO:0000050 GO:0051321 ! part of meiotic cell cycle
created_by: jl
creation_date: 2014-05-22T14:22:28Z

[Term]
id: GO:1903047
name: mitotic cell cycle process
namespace: biological_process
def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0009987 ! cellular process
intersection_of: BFO:0000050 GO:0000278 ! part of mitotic cell cycle
relationship: BFO:0000050 GO:0000278 ! part of mitotic cell cycle
creation_date: 2014-05-22T14:22:34Z

[Term]
id: GO:1903053
name: regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030198 ! regulates extracellular matrix organization
relationship: RO:0002211 GO:0030198 ! regulates extracellular matrix organization
creation_date: 2014-05-23T17:15:41Z

[Term]
id: GO:1903054
name: negative regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization
relationship: RO:0002212 GO:0030198 ! negatively regulates extracellular matrix organization
creation_date: 2014-05-23T17:15:47Z

[Term]
id: GO:1903055
name: positive regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization
relationship: RO:0002213 GO:0030198 ! positively regulates extracellular matrix organization
creation_date: 2014-05-23T17:15:53Z

[Term]
id: GO:1903076
name: regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090003
alt_id: GO:1905963
def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "regulation of establishment of protein localization in plasma membrane" RELATED []
synonym: "regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie]
synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein targeting to plasma membrane" RELATED []
synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane
relationship: RO:0002211 GO:0072659 ! regulates protein localization to plasma membrane
created_by: tb
creation_date: 2009-07-10T10:32:44Z

[Term]
id: GO:1903077
name: negative regulation of protein localization to plasma membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED []
synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein targeting to plasma membrane" RELATED []
synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1905476 ! negative regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane
relationship: RO:0002212 GO:0072659 ! negatively regulates protein localization to plasma membrane
creation_date: 2014-05-29T17:10:16Z

[Term]
id: GO:1903078
name: positive regulation of protein localization to plasma membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein targeting to plasma membrane" RELATED []
synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1905477 ! positive regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane
relationship: RO:0002213 GO:0072659 ! positively regulates protein localization to plasma membrane
creation_date: 2009-07-10T10:34:17Z

[Term]
id: GO:1903115
name: regulation of actin filament-based movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
is_a: GO:0032970 ! regulation of actin filament-based process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030048 ! regulates actin filament-based movement
relationship: RO:0002211 GO:0030048 ! regulates actin filament-based movement
creation_date: 2014-06-12T16:55:57Z

[Term]
id: GO:1903116
name: positive regulation of actin filament-based movement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie]
synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903115 ! regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement
relationship: RO:0002213 GO:0030048 ! positively regulates actin filament-based movement
creation_date: 2014-06-12T16:56:04Z

[Term]
id: GO:1903119
name: protein localization to actin cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie]
is_a: GO:0044380 ! protein localization to cytoskeleton
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton
relationship: RO:0002339 GO:0015629 ! has target end location actin cytoskeleton
creation_date: 2014-06-16T11:27:09Z

[Term]
id: GO:1903120
name: protein localization to actin filament bundle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization to actin cable" RELATED [GOC:mah]
is_a: GO:1903119 ! protein localization to actin cytoskeleton
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0032432 ! has target end location actin filament bundle
relationship: RO:0002339 GO:0032432 ! has target end location actin filament bundle
creation_date: 2014-06-16T11:27:16Z

[Term]
id: GO:1903131
name: mononuclear cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]
is_a: GO:0002521 ! leukocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000842 ! results in acquisition of features of mononuclear leukocyte
relationship: RO:0002315 CL:0000842 ! results in acquisition of features of mononuclear leukocyte
creation_date: 2014-06-25T15:47:09Z

[Term]
id: GO:1903179
name: regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "regulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0042053 ! regulation of dopamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042416 ! regulates dopamine biosynthetic process
relationship: RO:0002211 GO:0042416 ! regulates dopamine biosynthetic process
creation_date: 2014-07-14T12:17:41Z

[Term]
id: GO:1903180
name: negative regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of dopamine anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine formation" NARROW [GOC:TermGenie]
synonym: "inhibition of dopamine synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045963 ! negative regulation of dopamine metabolic process
is_a: GO:1903179 ! regulation of dopamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042416 ! negatively regulates dopamine biosynthetic process
relationship: RO:0002212 GO:0042416 ! negatively regulates dopamine biosynthetic process
creation_date: 2014-07-14T12:17:47Z

[Term]
id: GO:1903181
name: positive regulation of dopamine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902]
synonym: "activation of dopamine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of dopamine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of dopamine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of dopamine formation" NARROW [GOC:TermGenie]
synonym: "activation of dopamine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopamine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of dopamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045964 ! positive regulation of dopamine metabolic process
is_a: GO:1903179 ! regulation of dopamine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042416 ! positively regulates dopamine biosynthetic process
relationship: RO:0002213 GO:0042416 ! positively regulates dopamine biosynthetic process
creation_date: 2014-07-14T12:17:53Z

[Term]
id: GO:1903224
name: regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation
relationship: RO:0002211 GO:0035987 ! regulates endodermal cell differentiation
creation_date: 2014-07-29T13:22:35Z

[Term]
id: GO:1903225
name: negative regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation
relationship: RO:0002212 GO:0035987 ! negatively regulates endodermal cell differentiation
creation_date: 2014-07-29T13:22:41Z

[Term]
id: GO:1903226
name: positive regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation
relationship: RO:0002213 GO:0035987 ! positively regulates endodermal cell differentiation
creation_date: 2014-07-29T13:22:47Z

[Term]
id: GO:1903292
name: protein localization to Golgi membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]
synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie]
is_a: GO:0034067 ! protein localization to Golgi apparatus
is_a: GO:0072657 ! protein localization to membrane
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0000139 ! has target end location Golgi membrane
relationship: RO:0002339 GO:0000139 ! has target end location Golgi membrane
creation_date: 2014-08-12T14:22:31Z

[Term]
id: GO:1903294
name: regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061535 ! regulates glutamate secretion, neurotransmission
relationship: RO:0002211 GO:0061535 ! regulates glutamate secretion, neurotransmission
creation_date: 2014-08-13T13:54:15Z

[Term]
id: GO:1903295
name: negative regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0014050 ! negative regulation of glutamate secretion
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic
is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061535 ! negatively regulates glutamate secretion, neurotransmission
relationship: RO:0002212 GO:0061535 ! negatively regulates glutamate secretion, neurotransmission
creation_date: 2014-08-13T13:54:23Z

[Term]
id: GO:1903296
name: positive regulation of glutamate secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]
comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype
synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014049 ! positive regulation of glutamate secretion
is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic
is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061535 ! positively regulates glutamate secretion, neurotransmission
relationship: RO:0002213 GO:0061535 ! positively regulates glutamate secretion, neurotransmission
creation_date: 2014-08-13T13:54:31Z

[Term]
id: GO:1903326
name: regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006399 ! regulates tRNA metabolic process
relationship: RO:0002211 GO:0006399 ! regulates tRNA metabolic process
creation_date: 2014-08-18T13:08:50Z

[Term]
id: GO:1903327
name: negative regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tRNA metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006399 ! negatively regulates tRNA metabolic process
relationship: RO:0002212 GO:0006399 ! negatively regulates tRNA metabolic process
creation_date: 2014-08-18T13:08:58Z

[Term]
id: GO:1903328
name: positive regulation of tRNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of tRNA metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tRNA metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tRNA metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tRNA metabolism" EXACT [GOC:TermGenie]
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:1903326 ! regulation of tRNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006399 ! positively regulates tRNA metabolic process
relationship: RO:0002213 GO:0006399 ! positively regulates tRNA metabolic process
creation_date: 2014-08-18T13:09:06Z

[Term]
id: GO:1903335
name: regulation of vacuolar transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007034 ! regulates vacuolar transport
relationship: RO:0002211 GO:0007034 ! regulates vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:04Z

[Term]
id: GO:1903336
name: negative regulation of vacuolar transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport
relationship: RO:0002212 GO:0007034 ! negatively regulates vacuolar transport
creation_date: 2014-08-18T13:16:11Z

[Term]
id: GO:1903337
name: positive regulation of vacuolar transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie]
synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007034 ! positively regulates vacuolar transport
relationship: RO:0002213 GO:0007034 ! positively regulates vacuolar transport
creation_date: 2014-08-18T13:16:19Z

[Term]
id: GO:1903338
name: regulation of cell wall organization or biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie]
synonym: "regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071554 ! regulates cell wall organization or biogenesis
relationship: RO:0002211 GO:0071554 ! regulates cell wall organization or biogenesis
created_by: vw
creation_date: 2014-08-18T13:20:50Z

[Term]
id: GO:1903347
name: negative regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]
synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie]
synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:2000810 ! regulation of bicellular tight junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070830 ! negatively regulates bicellular tight junction assembly
relationship: RO:0002212 GO:0070830 ! negatively regulates bicellular tight junction assembly
creation_date: 2014-08-19T11:02:14Z

[Term]
id: GO:1903348
name: positive regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009]
synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie]
synonym: "activation of tight junction formation" NARROW [GOC:TermGenie]
synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie]
is_a: GO:1901890 ! positive regulation of cell junction assembly
is_a: GO:2000810 ! regulation of bicellular tight junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070830 ! positively regulates bicellular tight junction assembly
relationship: RO:0002213 GO:0070830 ! positively regulates bicellular tight junction assembly
creation_date: 2014-08-19T11:05:06Z

[Term]
id: GO:1903350
name: response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
is_a: GO:0071869 ! response to catecholamine
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
relationship: RO:0004009 CHEBI:59905 ! has primary input
creation_date: 2014-08-19T19:33:26Z

[Term]
id: GO:1903351
name: cellular response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:1903350 ! response to dopamine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:59905 ! has primary input
creation_date: 2014-08-19T19:33:35Z

[Term]
id: GO:1903353
name: regulation of nucleus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282]
synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006997 ! regulates nucleus organization
relationship: RO:0002211 GO:0006997 ! regulates nucleus organization
created_by: hjd
creation_date: 2014-08-20T19:36:16Z

[Term]
id: GO:1903358
name: regulation of Golgi organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]
synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie]
synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007030 ! regulates Golgi organization
relationship: RO:0002211 GO:0007030 ! regulates Golgi organization
creation_date: 2014-08-21T10:22:22Z

[Term]
id: GO:1903379
name: regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0060623 ! regulation of chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation
relationship: RO:0002211 GO:0007076 ! regulates mitotic chromosome condensation
creation_date: 2014-08-26T13:57:13Z

[Term]
id: GO:1903380
name: positive regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
is_a: GO:1905821 ! positive regulation of chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation
relationship: RO:0002213 GO:0007076 ! positively regulates mitotic chromosome condensation
creation_date: 2014-08-26T13:57:29Z

[Term]
id: GO:1903409
name: reactive oxygen species biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "reactive oxygen species generation" RELATED [PMID:24252804]
synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "ROS formation" RELATED []
synonym: "ROS generation" RELATED [PMID:24252804]
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072593 ! reactive oxygen species metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26523 ! has primary output reactive oxygen species
relationship: RO:0004008 CHEBI:26523 ! has primary output reactive oxygen species
created_by: bf
creation_date: 2014-09-03T09:19:13Z

[Term]
id: GO:1903426
name: regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "regulation of ROS generation" RELATED [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1903409 ! regulates reactive oxygen species biosynthetic process
relationship: RO:0002211 GO:1903409 ! regulates reactive oxygen species biosynthetic process
created_by: bf
creation_date: 2014-09-11T10:01:47Z

[Term]
id: GO:1903427
name: negative regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie]
synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "prevention of ROS generation" EXACT [PMID:24252804]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1903409 ! negatively regulates reactive oxygen species biosynthetic process
relationship: RO:0002212 GO:1903409 ! negatively regulates reactive oxygen species biosynthetic process
creation_date: 2014-09-11T10:01:56Z

[Term]
id: GO:1903428
name: positive regulation of reactive oxygen species biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]
synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie]
synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie]
synonym: "activation of ROS formation" RELATED [GOC:TermGenie]
synonym: "activation of ROS generation" RELATED [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie]
synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie]
synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1903409 ! positively regulates reactive oxygen species biosynthetic process
relationship: RO:0002213 GO:1903409 ! positively regulates reactive oxygen species biosynthetic process
creation_date: 2014-09-11T10:02:05Z

[Term]
id: GO:1903429
name: regulation of cell maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048469 ! regulates cell maturation
relationship: RO:0002211 GO:0048469 ! regulates cell maturation
creation_date: 2014-09-15T13:31:23Z

[Term]
id: GO:1903430
name: negative regulation of cell maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048469 ! negatively regulates cell maturation
relationship: RO:0002212 GO:0048469 ! negatively regulates cell maturation
creation_date: 2014-09-15T13:31:32Z

[Term]
id: GO:1903431
name: positive regulation of cell maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "activation of cell maturation" NARROW [GOC:TermGenie]
synonym: "activation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048469 ! positively regulates cell maturation
relationship: RO:0002213 GO:0048469 ! positively regulates cell maturation
creation_date: 2014-09-15T13:31:41Z

[Term]
id: GO:1903441
name: protein localization to ciliary membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]
synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0060170 ! has target end location ciliary membrane
relationship: RO:0002339 GO:0060170 ! has target end location ciliary membrane
creation_date: 2014-09-16T15:15:39Z

[Term]
id: GO:1903522
name: regulation of blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008015 ! regulates blood circulation
relationship: RO:0002211 GO:0008015 ! regulates blood circulation
creation_date: 2014-10-06T18:38:56Z

[Term]
id: GO:1903523
name: negative regulation of blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008015 ! negatively regulates blood circulation
relationship: RO:0002212 GO:0008015 ! negatively regulates blood circulation
creation_date: 2014-10-06T18:39:05Z

[Term]
id: GO:1903524
name: positive regulation of blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "activation of blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008015 ! positively regulates blood circulation
relationship: RO:0002213 GO:0008015 ! positively regulates blood circulation
creation_date: 2014-10-06T18:39:13Z

[Term]
id: GO:1903530
name: regulation of secretion by cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032940 ! regulates secretion by cell
relationship: RO:0002211 GO:0032940 ! regulates secretion by cell
created_by: pm
creation_date: 2014-10-08T13:24:59Z

[Term]
id: GO:1903531
name: negative regulation of secretion by cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032940 ! negatively regulates secretion by cell
relationship: RO:0002212 GO:0032940 ! negatively regulates secretion by cell
creation_date: 2014-10-08T13:25:08Z

[Term]
id: GO:1903532
name: positive regulation of secretion by cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "activation of cellular secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion by cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032940 ! positively regulates secretion by cell
relationship: RO:0002213 GO:0032940 ! positively regulates secretion by cell
creation_date: 2014-10-08T13:25:17Z

[Term]
id: GO:1903537
name: meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "meiosis involved in oocyte maturation" BROAD []
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1903046 ! meiotic cell cycle process
intersection_of: BFO:0000050 GO:0001556 ! part of oocyte maturation
relationship: BFO:0000050 GO:0001556 ! part of oocyte maturation
creation_date: 2014-10-09T10:46:14Z

[Term]
id: GO:1903538
name: regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation
relationship: RO:0002211 GO:1903537 ! regulates meiotic cell cycle process involved in oocyte maturation
creation_date: 2014-10-09T10:52:38Z

[Term]
id: GO:1903539
name: protein localization to postsynaptic membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322]
synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0062237 ! protein localization to postsynapse
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane
relationship: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane
creation_date: 2014-10-10T11:23:53Z

[Term]
id: GO:1903540
name: establishment of protein localization to postsynaptic membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322]
synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie]
synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie]
is_a: GO:0090150 ! establishment of protein localization to membrane
is_a: GO:1903539 ! protein localization to postsynaptic membrane
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0045211 ! has target end location postsynaptic membrane
creation_date: 2014-10-10T11:24:03Z

[Term]
id: GO:1903541
name: regulation of exosomal secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0017157 ! regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990182 ! regulates exosomal secretion
relationship: RO:0002211 GO:1990182 ! regulates exosomal secretion
creation_date: 2014-10-14T11:38:52Z

[Term]
id: GO:1903542
name: negative regulation of exosomal secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion
relationship: RO:0002212 GO:1990182 ! negatively regulates exosomal secretion
creation_date: 2014-10-14T11:39:02Z

[Term]
id: GO:1903543
name: positive regulation of exosomal secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990182 ! positively regulates exosomal secretion
relationship: RO:0002213 GO:1990182 ! positively regulates exosomal secretion
creation_date: 2014-10-14T11:39:10Z

[Term]
id: GO:1903551
name: regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly
relationship: RO:0002211 GO:0071971 ! regulates extracellular exosome assembly
creation_date: 2014-10-20T15:37:25Z

[Term]
id: GO:1903552
name: negative regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly
relationship: RO:0002212 GO:0071971 ! negatively regulates extracellular exosome assembly
creation_date: 2014-10-20T15:37:33Z

[Term]
id: GO:1903553
name: positive regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles]
synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly
relationship: RO:0002213 GO:0071971 ! positively regulates extracellular exosome assembly
creation_date: 2014-10-20T15:37:42Z

[Term]
id: GO:1903561
name: extracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]
synonym: "microparticle" RELATED [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0065010 ! extracellular membrane-bounded organelle
intersection_of: GO:0031982 ! vesicle
intersection_of: BFO:0000050 GO:0005576 ! part of extracellular region
creation_date: 2014-10-22T14:26:11Z

[Term]
id: GO:1903564
name: regulation of protein localization to cilium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061512 ! regulates protein localization to cilium
relationship: RO:0002211 GO:0061512 ! regulates protein localization to cilium
creation_date: 2014-10-24T20:58:11Z

[Term]
id: GO:1903565
name: negative regulation of protein localization to cilium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium
relationship: RO:0002212 GO:0061512 ! negatively regulates protein localization to cilium
creation_date: 2014-10-24T20:58:20Z

[Term]
id: GO:1903566
name: positive regulation of protein localization to cilium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium
relationship: RO:0002213 GO:0061512 ! positively regulates protein localization to cilium
creation_date: 2014-10-24T20:58:28Z

[Term]
id: GO:1903567
name: regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane
relationship: RO:0002211 GO:1903441 ! regulates protein localization to ciliary membrane
creation_date: 2014-10-24T21:32:51Z

[Term]
id: GO:1903568
name: negative regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903565 ! negative regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1905476 ! negative regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane
relationship: RO:0002212 GO:1903441 ! negatively regulates protein localization to ciliary membrane
creation_date: 2014-10-24T21:32:59Z

[Term]
id: GO:1903569
name: positive regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903566 ! positive regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1905477 ! positive regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane
relationship: RO:0002213 GO:1903441 ! positively regulates protein localization to ciliary membrane
creation_date: 2014-10-24T21:33:08Z

[Term]
id: GO:1903624
name: regulation of DNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006308 ! regulates DNA catabolic process
relationship: RO:0002211 GO:0006308 ! regulates DNA catabolic process
creation_date: 2014-11-19T22:36:35Z

[Term]
id: GO:1903625
name: negative regulation of DNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006308 ! negatively regulates DNA catabolic process
relationship: RO:0002212 GO:0006308 ! negatively regulates DNA catabolic process
creation_date: 2014-11-19T22:36:43Z

[Term]
id: GO:1903626
name: positive regulation of DNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "activation of DNA degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006308 ! positively regulates DNA catabolic process
relationship: RO:0002213 GO:0006308 ! positively regulates DNA catabolic process
creation_date: 2014-11-19T22:36:51Z

[Term]
id: GO:1903664
name: regulation of asexual reproduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142]
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0019954 ! regulates asexual reproduction
relationship: RO:0002211 GO:0019954 ! regulates asexual reproduction
created_by: pf
creation_date: 2014-11-26T21:13:24Z

[Term]
id: GO:1903697
name: negative regulation of microvillus assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly
relationship: RO:0002212 GO:0030033 ! negatively regulates microvillus assembly
creation_date: 2014-12-03T11:45:08Z

[Term]
id: GO:1903698
name: positive regulation of microvillus assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030033 ! positively regulates microvillus assembly
relationship: RO:0002213 GO:0030033 ! positively regulates microvillus assembly
creation_date: 2014-12-03T11:45:17Z

[Term]
id: GO:1903701
name: substantia propria of cornea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382]
synonym: "corneal stroma development" EXACT [GOC:TermGenie]
synonym: "stroma of cornea development" EXACT [GOC:TermGenie]
synonym: "substantia propria development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea
relationship: RO:0002296 UBERON:0001777 ! results in development of substantia propria of cornea
creation_date: 2014-12-03T13:12:09Z

[Term]
id: GO:1903702
name: esophagus development
namespace: biological_process
def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]
synonym: "esophageal development" EXACT [MGI:csmith]
synonym: "gullet development" EXACT [GOC:TermGenie]
synonym: "oesophagus development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001043 ! results in development of esophagus
relationship: RO:0002296 UBERON:0001043 ! results in development of esophagus
creation_date: 2014-12-03T14:41:30Z

[Term]
id: GO:1903706
name: regulation of hemopoiesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030097 ! regulates hemopoiesis
relationship: RO:0002211 GO:0030097 ! regulates hemopoiesis
creation_date: 2014-12-04T15:34:13Z

[Term]
id: GO:1903707
name: negative regulation of hemopoiesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis
relationship: RO:0002212 GO:0030097 ! negatively regulates hemopoiesis
creation_date: 2014-12-04T15:34:21Z

[Term]
id: GO:1903708
name: positive regulation of hemopoiesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of blood cell formation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030097 ! positively regulates hemopoiesis
relationship: RO:0002213 GO:0030097 ! positively regulates hemopoiesis
creation_date: 2014-12-04T15:34:30Z

[Term]
id: GO:1903729
name: regulation of plasma membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900]
synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie]
synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007009 ! regulates plasma membrane organization
relationship: RO:0002211 GO:0007009 ! regulates plasma membrane organization
created_by: al
creation_date: 2014-12-10T18:59:44Z

[Term]
id: GO:1903747
name: regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072655 ! regulates establishment of protein localization to mitochondrion
relationship: RO:0002211 GO:0072655 ! regulates establishment of protein localization to mitochondrion
creation_date: 2014-12-12T22:18:09Z

[Term]
id: GO:1903748
name: negative regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072655 ! negatively regulates establishment of protein localization to mitochondrion
relationship: RO:0002212 GO:0072655 ! negatively regulates establishment of protein localization to mitochondrion
creation_date: 2014-12-12T22:18:18Z

[Term]
id: GO:1903749
name: positive regulation of establishment of protein localization to mitochondrion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185]
synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie]
xref: Reactome:R-HSA-114452 "Activation of BH3-only proteins"
xref: Reactome:R-HSA-75108 "Activation, myristolyation of BID and translocation to mitochondria"
is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072655 ! positively regulates establishment of protein localization to mitochondrion
relationship: RO:0002213 GO:0072655 ! positively regulates establishment of protein localization to mitochondrion
creation_date: 2014-12-12T22:18:26Z

[Term]
id: GO:1903778
name: protein localization to vacuolar membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562]
synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0072665 ! protein localization to vacuole
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005774 ! has target end location vacuolar membrane
relationship: RO:0002339 GO:0005774 ! has target end location vacuolar membrane
creation_date: 2015-01-07T13:15:54Z

[Term]
id: GO:1903779
name: regulation of cardiac conduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
xref: Reactome:R-HSA-5578768 "Physiological factors"
xref: Reactome:R-HSA-5578775 "Ion homeostasis"
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061337 ! regulates cardiac conduction
relationship: RO:0002211 GO:0061337 ! regulates cardiac conduction
creation_date: 2015-01-07T13:20:11Z

[Term]
id: GO:1903780
name: negative regulation of cardiac conduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction
relationship: RO:0002212 GO:0061337 ! negatively regulates cardiac conduction
creation_date: 2015-01-07T13:20:20Z

[Term]
id: GO:1903781
name: positive regulation of cardiac conduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061337 ! positively regulates cardiac conduction
relationship: RO:0002213 GO:0061337 ! positively regulates cardiac conduction
creation_date: 2015-01-07T13:20:28Z

[Term]
id: GO:1903789
name: regulation of amino acid transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814]
synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport
relationship: RO:0002211 GO:0003333 ! regulates amino acid transmembrane transport
creation_date: 2015-01-08T17:42:18Z

[Term]
id: GO:1903804
name: glycine import across plasma membrane
namespace: biological_process
def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "glycine import" BROAD []
synonym: "glycine import into cell" EXACT []
is_a: GO:0015816 ! glycine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1905039 ! carboxylic acid transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
creation_date: 2012-05-11T01:16:45Z

[Term]
id: GO:1903828
name: negative regulation of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein localization" EXACT []
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008104 ! negatively regulates intracellular protein localization
relationship: RO:0002212 GO:0008104 ! negatively regulates intracellular protein localization
creation_date: 2015-01-20T14:32:24Z

[Term]
id: GO:1903829
name: positive regulation of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein localization" EXACT []
synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008104 ! positively regulates intracellular protein localization
relationship: RO:0002213 GO:0008104 ! positively regulates intracellular protein localization
creation_date: 2015-01-20T14:32:33Z

[Term]
id: GO:1903847
name: regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
is_a: GO:1905651 ! regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035909 ! regulates aorta morphogenesis
relationship: RO:0002211 GO:0035909 ! regulates aorta morphogenesis
creation_date: 2015-01-23T14:00:51Z

[Term]
id: GO:1903848
name: negative regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1905652 ! negative regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis
relationship: RO:0002212 GO:0035909 ! negatively regulates aorta morphogenesis
creation_date: 2015-01-23T14:01:01Z

[Term]
id: GO:1903849
name: positive regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1905653 ! positive regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis
relationship: RO:0002213 GO:0035909 ! positively regulates aorta morphogenesis
creation_date: 2015-01-23T14:01:09Z

[Term]
id: GO:1903867
name: extraembryonic membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane
relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa
relationship: RO:0002296 UBERON:0005631 ! results in development of extraembryonic membrane
creation_date: 2015-02-05T00:42:16Z

[Term]
id: GO:1903903
name: regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:2000114 ! regulation of establishment of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001768 ! regulates establishment of T cell polarity
relationship: RO:0002211 GO:0001768 ! regulates establishment of T cell polarity
creation_date: 2015-02-09T10:50:21Z

[Term]
id: GO:1903904
name: negative regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050868 ! negative regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001768 ! negatively regulates establishment of T cell polarity
relationship: RO:0002212 GO:0001768 ! negatively regulates establishment of T cell polarity
creation_date: 2015-02-09T10:50:30Z

[Term]
id: GO:1903905
name: positive regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of T cell polarization" NARROW [GOC:TermGenie]
synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001768 ! positively regulates establishment of T cell polarity
relationship: RO:0002213 GO:0001768 ! positively regulates establishment of T cell polarity
creation_date: 2015-02-09T10:50:40Z

[Term]
id: GO:1903941
name: negative regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system
relationship: RO:0002212 GO:0007585 ! negatively regulates respiratory gaseous exchange by respiratory system
creation_date: 2015-02-17T20:26:24Z

[Term]
id: GO:1903942
name: positive regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie]
synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system
relationship: RO:0002213 GO:0007585 ! positively regulates respiratory gaseous exchange by respiratory system
creation_date: 2015-02-17T20:26:35Z

[Term]
id: GO:1903950
name: negative regulation of AV node cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential
relationship: RO:0002212 GO:0086016 ! negatively regulates AV node cell action potential
creation_date: 2015-02-20T14:59:41Z

[Term]
id: GO:1903951
name: positive regulation of AV node cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential
relationship: RO:0002213 GO:0086016 ! positively regulates AV node cell action potential
creation_date: 2015-02-20T14:59:50Z

[Term]
id: GO:1903975
name: regulation of glial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008347 ! regulates glial cell migration
relationship: RO:0002211 GO:0008347 ! regulates glial cell migration
creation_date: 2015-03-02T15:13:31Z

[Term]
id: GO:1903976
name: negative regulation of glial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008347 ! negatively regulates glial cell migration
relationship: RO:0002212 GO:0008347 ! negatively regulates glial cell migration
creation_date: 2015-03-02T15:13:38Z

[Term]
id: GO:1903977
name: positive regulation of glial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of glia cell migration" NARROW [GOC:TermGenie]
synonym: "activation of glial cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008347 ! positively regulates glial cell migration
relationship: RO:0002213 GO:0008347 ! positively regulates glial cell migration
creation_date: 2015-03-02T15:13:43Z

[Term]
id: GO:1903978
name: regulation of microglial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0043030 ! regulation of macrophage activation
is_a: GO:0150077 ! regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001774 ! regulates microglial cell activation
relationship: RO:0002211 GO:0001774 ! regulates microglial cell activation
creation_date: 2015-03-02T15:17:33Z

[Term]
id: GO:1903979
name: negative regulation of microglial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0043031 ! negative regulation of macrophage activation
is_a: GO:0150079 ! negative regulation of neuroinflammatory response
is_a: GO:1903978 ! regulation of microglial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001774 ! negatively regulates microglial cell activation
relationship: RO:0002212 GO:0001774 ! negatively regulates microglial cell activation
creation_date: 2015-03-02T15:17:39Z

[Term]
id: GO:1903980
name: positive regulation of microglial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0043032 ! positive regulation of macrophage activation
is_a: GO:0150078 ! positive regulation of neuroinflammatory response
is_a: GO:1903978 ! regulation of microglial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001774 ! positively regulates microglial cell activation
relationship: RO:0002213 GO:0001774 ! positively regulates microglial cell activation
creation_date: 2015-03-02T15:17:44Z

[Term]
id: GO:1904014
name: response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:350546 ! has primary input
relationship: RO:0004009 CHEBI:350546 ! has primary input
creation_date: 2015-03-06T19:33:54Z

[Term]
id: GO:1904015
name: cellular response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:0071868 ! cellular response to monoamine stimulus
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904014 ! response to serotonin
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:350546 ! has primary input
creation_date: 2015-03-06T19:34:00Z

[Term]
id: GO:1904018
name: positive regulation of vasculature development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453]
synonym: "activation of vascular system development" RELATED [GOC:TermGenie]
synonym: "activation of vasculature development" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001944 ! positively regulates vasculature development
relationship: RO:0002213 GO:0001944 ! positively regulates vasculature development
creation_date: 2015-03-06T22:17:04Z

[Term]
id: GO:1904019
name: epithelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015]
synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000066 ! occurs in epithelial cell
relationship: BFO:0000066 CL:0000066 ! occurs in epithelial cell
creation_date: 2015-03-06T22:27:17Z

[Term]
id: GO:1904026
name: regulation of collagen fibril organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "regulation of collagen fibrillogenesis" RELATED []
synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030199 ! regulates collagen fibril organization
relationship: RO:0002211 GO:0030199 ! regulates collagen fibril organization
creation_date: 2015-03-12T12:36:52Z

[Term]
id: GO:1904027
name: negative regulation of collagen fibril organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization
relationship: RO:0002212 GO:0030199 ! negatively regulates collagen fibril organization
creation_date: 2015-03-12T12:36:59Z

[Term]
id: GO:1904028
name: positive regulation of collagen fibril organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization
relationship: RO:0002213 GO:0030199 ! positively regulates collagen fibril organization
creation_date: 2015-03-12T12:37:06Z

[Term]
id: GO:1904035
name: regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process
relationship: RO:0002211 GO:1904019 ! regulates epithelial cell apoptotic process
creation_date: 2015-03-13T22:05:41Z

[Term]
id: GO:1904036
name: negative regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process
relationship: RO:0002212 GO:1904019 ! negatively regulates epithelial cell apoptotic process
creation_date: 2015-03-13T22:05:47Z

[Term]
id: GO:1904037
name: positive regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process
relationship: RO:0002213 GO:1904019 ! positively regulates epithelial cell apoptotic process
creation_date: 2015-03-13T22:05:53Z

[Term]
id: GO:1904057
name: negative regulation of sensory perception of pain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "down regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "down-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "downregulation of nociception" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "inhibition of nociception" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "negative regulation of nociception" EXACT [GOC:TermGenie]
synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0051930 ! regulation of sensory perception of pain
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain
relationship: RO:0002212 GO:0019233 ! negatively regulates sensory perception of pain
creation_date: 2015-03-18T20:33:57Z

[Term]
id: GO:1904058
name: positive regulation of sensory perception of pain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "activation of nociception" NARROW [GOC:TermGenie]
synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "positive regulation of nociception" EXACT [GOC:TermGenie]
synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "up-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "upregulation of nociception" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0051930 ! regulation of sensory perception of pain
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain
relationship: RO:0002213 GO:0019233 ! positively regulates sensory perception of pain
creation_date: 2015-03-18T20:34:03Z

[Term]
id: GO:1904065
name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT []
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie]
synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie]
is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway
intersection_of: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway
intersection_of: BFO:0000050 GO:0014057 ! part of positive regulation of acetylcholine secretion, neurotransmission
relationship: BFO:0000050 GO:0014057 ! part of positive regulation of acetylcholine secretion, neurotransmission
creation_date: 2015-03-19T15:28:47Z

[Term]
id: GO:1904073
name: regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation
relationship: RO:0002211 GO:0001834 ! regulates trophectodermal cell proliferation
creation_date: 2015-03-20T16:55:56Z

[Term]
id: GO:1904074
name: negative regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation
relationship: RO:0002212 GO:0001834 ! negatively regulates trophectodermal cell proliferation
creation_date: 2015-03-20T16:56:02Z

[Term]
id: GO:1904075
name: positive regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation
relationship: RO:0002213 GO:0001834 ! positively regulates trophectodermal cell proliferation
creation_date: 2015-03-20T16:56:08Z

[Term]
id: GO:1904092
name: regulation of autophagic cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836]
synonym: "regulation of autophagic death" BROAD [GOC:TermGenie]
synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie]
synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie]
synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie]
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048102 ! regulates autophagic cell death
relationship: RO:0002211 GO:0048102 ! regulates autophagic cell death
created_by: bhm
creation_date: 2015-03-26T16:41:32Z

[Term]
id: GO:1904106
name: protein localization to microvillus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie]
synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie]
synonym: "protein localization in microvillus" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005902 ! has target end location microvillus
relationship: RO:0002339 GO:0005902 ! has target end location microvillus
creation_date: 2015-04-01T18:14:41Z

[Term]
id: GO:1904115
name: axon cytoplasm
namespace: cellular_component
def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152]
synonym: "axoplasm" EXACT []
is_a: GO:0120111 ! neuron projection cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 GO:0030424 ! part of axon
relationship: BFO:0000050 GO:0030424 ! part of axon
creation_date: 2015-04-06T18:13:14Z

[Term]
id: GO:1904116
name: response to vasopressin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487]
is_a: GO:0043434 ! response to peptide hormone
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:9937 ! has primary input
relationship: RO:0004009 CHEBI:9937 ! has primary input
creation_date: 2015-04-06T19:39:42Z

[Term]
id: GO:1904117
name: cellular response to vasopressin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487]
is_a: GO:0071375 ! cellular response to peptide hormone stimulus
is_a: GO:1904116 ! response to vasopressin
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:9937 ! has primary input
creation_date: 2015-04-06T19:39:48Z

[Term]
id: GO:1904124
name: microglial cell migration
namespace: biological_process
def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:0008347 ! glial cell migration
is_a: GO:1905517 ! macrophage migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000129 ! results in movement of microglial cell
relationship: RO:0002565 CL:0000129 ! results in movement of microglial cell
creation_date: 2015-04-10T16:04:49Z

[Term]
id: GO:1904139
name: regulation of microglial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
is_a: GO:1903975 ! regulation of glial cell migration
is_a: GO:1905521 ! regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1904124 ! regulates microglial cell migration
relationship: RO:0002211 GO:1904124 ! regulates microglial cell migration
creation_date: 2015-04-13T09:06:57Z

[Term]
id: GO:1904140
name: negative regulation of microglial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie]
is_a: GO:1903976 ! negative regulation of glial cell migration
is_a: GO:1904139 ! regulation of microglial cell migration
is_a: GO:1905522 ! negative regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1904124 ! negatively regulates microglial cell migration
relationship: RO:0002212 GO:1904124 ! negatively regulates microglial cell migration
creation_date: 2015-04-13T09:07:03Z

[Term]
id: GO:1904141
name: positive regulation of microglial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie]
is_a: GO:1903977 ! positive regulation of glial cell migration
is_a: GO:1904139 ! regulation of microglial cell migration
is_a: GO:1905523 ! positive regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1904124 ! positively regulates microglial cell migration
relationship: RO:0002213 GO:1904124 ! positively regulates microglial cell migration
creation_date: 2015-04-13T09:07:11Z

[Term]
id: GO:1904145
name: negative regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1900194 ! negative regulation of oocyte maturation
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation
relationship: RO:0002212 GO:1903537 ! negatively regulates meiotic cell cycle process involved in oocyte maturation
creation_date: 2015-04-14T15:59:22Z

[Term]
id: GO:1904146
name: positive regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation
relationship: RO:0002213 GO:1903537 ! positively regulates meiotic cell cycle process involved in oocyte maturation
creation_date: 2015-04-14T15:59:28Z

[Term]
id: GO:1904170
name: regulation of bleb assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0032060 ! regulates bleb assembly
relationship: RO:0002211 GO:0032060 ! regulates bleb assembly
creation_date: 2015-04-23T09:32:19Z

[Term]
id: GO:1904171
name: negative regulation of bleb assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1904170 ! regulation of bleb assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0032060 ! negatively regulates bleb assembly
relationship: RO:0002212 GO:0032060 ! negatively regulates bleb assembly
creation_date: 2015-04-23T09:32:25Z

[Term]
id: GO:1904172
name: positive regulation of bleb assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "activation of bleb assembly" NARROW [GOC:TermGenie]
synonym: "activation of cell blebbing" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1904170 ! regulation of bleb assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032060 ! positively regulates bleb assembly
relationship: RO:0002213 GO:0032060 ! positively regulates bleb assembly
creation_date: 2015-04-23T09:32:31Z

[Term]
id: GO:1904177
name: regulation of adipose tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie]
xref: Reactome:R-HSA-9843745 "Adipogenesis"
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060612 ! regulates adipose tissue development
relationship: RO:0002211 GO:0060612 ! regulates adipose tissue development
creation_date: 2015-04-29T20:01:01Z

[Term]
id: GO:1904178
name: negative regulation of adipose tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development
relationship: RO:0002212 GO:0060612 ! negatively regulates adipose tissue development
creation_date: 2015-04-29T20:01:07Z

[Term]
id: GO:1904179
name: positive regulation of adipose tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "activation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060612 ! positively regulates adipose tissue development
relationship: RO:0002213 GO:0060612 ! positively regulates adipose tissue development
creation_date: 2015-04-29T20:01:13Z

[Term]
id: GO:1904204
name: regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
is_a: GO:0014733 ! regulation of skeletal muscle adaptation
is_a: GO:0014743 ! regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy
relationship: RO:0002211 GO:0014734 ! regulates skeletal muscle hypertrophy
creation_date: 2015-05-08T17:38:13Z

[Term]
id: GO:1904205
name: negative regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy
relationship: RO:0002212 GO:0014734 ! negatively regulates skeletal muscle hypertrophy
creation_date: 2015-05-08T17:38:19Z

[Term]
id: GO:1904206
name: positive regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy
relationship: RO:0002213 GO:0014734 ! positively regulates skeletal muscle hypertrophy
creation_date: 2015-05-08T17:38:25Z

[Term]
id: GO:1904215
name: regulation of protein import into chloroplast stroma
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327]
synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0051223 ! regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0045037 ! regulates protein import into chloroplast stroma
relationship: RO:0002211 GO:0045037 ! regulates protein import into chloroplast stroma
creation_date: 2015-05-15T00:47:48Z

[Term]
id: GO:1904216
name: positive regulation of protein import into chloroplast stroma
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327]
synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie]
synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie]
synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie]
synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie]
synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1904215 ! regulation of protein import into chloroplast stroma
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045037 ! positively regulates protein import into chloroplast stroma
relationship: RO:0002213 GO:0045037 ! positively regulates protein import into chloroplast stroma
creation_date: 2015-05-15T00:47:55Z

[Term]
id: GO:1904266
name: regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1900147 ! regulation of Schwann cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990751 ! regulates Schwann cell chemotaxis
relationship: RO:0002211 GO:1990751 ! regulates Schwann cell chemotaxis
creation_date: 2015-05-28T17:47:41Z

[Term]
id: GO:1904267
name: negative regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1900148 ! negative regulation of Schwann cell migration
is_a: GO:1904266 ! regulation of Schwann cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990751 ! negatively regulates Schwann cell chemotaxis
relationship: RO:0002212 GO:1990751 ! negatively regulates Schwann cell chemotaxis
creation_date: 2015-05-28T17:47:48Z

[Term]
id: GO:1904268
name: positive regulation of Schwann cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995]
synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie]
synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1900149 ! positive regulation of Schwann cell migration
is_a: GO:1904266 ! regulation of Schwann cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990751 ! positively regulates Schwann cell chemotaxis
relationship: RO:0002213 GO:1990751 ! positively regulates Schwann cell chemotaxis
creation_date: 2015-05-28T17:47:55Z

[Term]
id: GO:1904269
name: cell leading edge cell cortex
namespace: cellular_component
def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030]
synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie]
synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie]
synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie]
synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie]
synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie]
synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: BFO:0000050 GO:0031252 ! part of cell leading edge
relationship: BFO:0000050 GO:0031252 ! part of cell leading edge
creation_date: 2015-05-28T19:16:03Z

[Term]
id: GO:1904338
name: regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071542 ! regulates dopaminergic neuron differentiation
relationship: RO:0002211 GO:0071542 ! regulates dopaminergic neuron differentiation
creation_date: 2015-06-11T18:06:19Z

[Term]
id: GO:1904339
name: negative regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
synonym: "down regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071542 ! negatively regulates dopaminergic neuron differentiation
relationship: RO:0002212 GO:0071542 ! negatively regulates dopaminergic neuron differentiation
creation_date: 2015-06-11T18:06:25Z

[Term]
id: GO:1904340
name: positive regulation of dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
synonym: "activation of dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071542 ! positively regulates dopaminergic neuron differentiation
relationship: RO:0002213 GO:0071542 ! positively regulates dopaminergic neuron differentiation
creation_date: 2015-06-11T18:06:32Z

[Term]
id: GO:1904350
name: regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0042176 ! regulation of protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole
relationship: RO:0002211 GO:0007039 ! regulates protein catabolic process in the vacuole
creation_date: 2015-06-12T09:10:36Z

[Term]
id: GO:1904351
name: negative regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole
relationship: RO:0002212 GO:0007039 ! negatively regulates protein catabolic process in the vacuole
creation_date: 2015-06-12T09:10:42Z

[Term]
id: GO:1904352
name: positive regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole
relationship: RO:0002213 GO:0007039 ! positively regulates protein catabolic process in the vacuole
creation_date: 2015-06-12T09:10:49Z

[Term]
id: GO:1904359
name: regulation of spore germination
namespace: biological_process
alt_id: GO:0075006
def: "Any process that modulates the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577]
synonym: "modulation of spore germination on or near host" NARROW []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009847 ! regulates spore germination
relationship: RO:0002211 GO:0009847 ! regulates spore germination
created_by: pf
creation_date: 2015-06-12T19:46:06Z

[Term]
id: GO:1904375
name: regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery
relationship: RO:0002211 GO:1990778 ! regulates protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:25Z

[Term]
id: GO:1904376
name: negative regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery
relationship: RO:0002212 GO:1990778 ! negatively regulates protein localization to cell periphery
creation_date: 2015-06-22T22:09:32Z

[Term]
id: GO:1904377
name: positive regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery
relationship: RO:0002213 GO:1990778 ! positively regulates protein localization to cell periphery
creation_date: 2015-06-22T22:09:37Z

[Term]
id: GO:1904396
name: regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007528 ! regulates neuromuscular junction development
relationship: RO:0002211 GO:0007528 ! regulates neuromuscular junction development
creation_date: 2015-06-23T19:23:42Z

[Term]
id: GO:1904397
name: negative regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:1904396 ! regulation of neuromuscular junction development
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development
relationship: RO:0002212 GO:0007528 ! negatively regulates neuromuscular junction development
creation_date: 2015-06-23T19:23:48Z

[Term]
id: GO:1904398
name: positive regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "activation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1904396 ! regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development
relationship: RO:0002213 GO:0007528 ! positively regulates neuromuscular junction development
creation_date: 2015-06-23T19:23:54Z

[Term]
id: GO:1904408
name: melatonin binding
namespace: molecular_function
def: "Binding to melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923]
is_a: GO:0033218 ! amide binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:16796 ! has primary input
relationship: RO:0004009 CHEBI:16796 ! has primary input
creation_date: 2015-06-25T19:19:53Z

[Term]
id: GO:1904409
name: regulation of secretory granule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0033363 ! regulates secretory granule organization
relationship: RO:0002211 GO:0033363 ! regulates secretory granule organization
creation_date: 2015-06-25T19:40:42Z

[Term]
id: GO:1904410
name: negative regulation of secretory granule organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization
relationship: RO:0002212 GO:0033363 ! negatively regulates secretory granule organization
creation_date: 2015-06-25T19:40:49Z

[Term]
id: GO:1904411
name: positive regulation of secretory granule organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0033363 ! positively regulates secretory granule organization
relationship: RO:0002213 GO:0033363 ! positively regulates secretory granule organization
creation_date: 2015-06-25T19:40:55Z

[Term]
id: GO:1904412
name: regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003231 ! regulates cardiac ventricle development
relationship: RO:0002211 GO:0003231 ! regulates cardiac ventricle development
creation_date: 2015-06-25T19:52:15Z

[Term]
id: GO:1904413
name: negative regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development
relationship: RO:0002212 GO:0003231 ! negatively regulates cardiac ventricle development
creation_date: 2015-06-25T19:52:21Z

[Term]
id: GO:1904414
name: positive regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development
relationship: RO:0002213 GO:0003231 ! positively regulates cardiac ventricle development
creation_date: 2015-06-25T19:52:27Z

[Term]
id: GO:1904456
name: negative regulation of neuronal action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie]
synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0051970 ! negative regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential
relationship: RO:0002212 GO:0019228 ! negatively regulates neuronal action potential
creation_date: 2015-07-09T18:02:40Z

[Term]
id: GO:1904457
name: positive regulation of neuronal action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "activation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0051971 ! positive regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0019228 ! positively regulates neuronal action potential
relationship: RO:0002213 GO:0019228 ! positively regulates neuronal action potential
creation_date: 2015-07-09T18:02:46Z

[Term]
id: GO:1904491
name: protein localization to ciliary transition zone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]
synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0035869 ! has target end location ciliary transition zone
relationship: RO:0002339 GO:0035869 ! has target end location ciliary transition zone
creation_date: 2015-07-17T20:43:21Z

[Term]
id: GO:1904587
name: response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "response to glycoproteins" EXACT []
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:17089 ! has primary input
relationship: RO:0004009 CHEBI:17089 ! has primary input
creation_date: 2015-08-20T16:46:24Z

[Term]
id: GO:1904588
name: cellular response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "cellular response to glycoproteins" EXACT []
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904587 ! response to glycoprotein
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:17089 ! has primary input
creation_date: 2015-08-20T16:46:30Z

[Term]
id: GO:1904606
name: fat cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416]
synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000136 ! occurs in adipocyte
relationship: BFO:0000066 CL:0000136 ! occurs in adipocyte
creation_date: 2015-08-27T18:13:06Z

[Term]
id: GO:1904624
name: regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061537 ! regulates glycine secretion, neurotransmission
relationship: RO:0002211 GO:0061537 ! regulates glycine secretion, neurotransmission
creation_date: 2015-08-27T20:03:38Z

[Term]
id: GO:1904625
name: negative regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061537 ! negatively regulates glycine secretion, neurotransmission
relationship: RO:0002212 GO:0061537 ! negatively regulates glycine secretion, neurotransmission
creation_date: 2015-08-27T20:03:44Z

[Term]
id: GO:1904626
name: positive regulation of glycine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142]
synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie]
synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie]
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061537 ! positively regulates glycine secretion, neurotransmission
relationship: RO:0002213 GO:0061537 ! positively regulates glycine secretion, neurotransmission
creation_date: 2015-08-27T20:03:49Z

[Term]
id: GO:1904649
name: regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process
relationship: RO:0002211 GO:1904606 ! regulates fat cell apoptotic process
creation_date: 2015-08-31T20:59:28Z

[Term]
id: GO:1904650
name: negative regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process
relationship: RO:0002212 GO:1904606 ! negatively regulates fat cell apoptotic process
creation_date: 2015-08-31T20:59:34Z

[Term]
id: GO:1904651
name: positive regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process
relationship: RO:0002213 GO:1904606 ! positively regulates fat cell apoptotic process
creation_date: 2015-08-31T20:59:40Z

[Term]
id: GO:1904675
name: regulation of somatic stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:2000035 ! regulation of stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048103 ! regulates somatic stem cell division
relationship: RO:0002211 GO:0048103 ! regulates somatic stem cell division
creation_date: 2015-09-14T08:47:22Z

[Term]
id: GO:1904676
name: negative regulation of somatic stem cell division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division
relationship: RO:0002212 GO:0048103 ! negatively regulates somatic stem cell division
creation_date: 2015-09-14T08:47:28Z

[Term]
id: GO:1904677
name: positive regulation of somatic stem cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division
relationship: RO:0002213 GO:0048103 ! positively regulates somatic stem cell division
creation_date: 2015-09-14T08:47:34Z

[Term]
id: GO:1904680
name: peptide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw]
synonym: "peptide transporter activity" RELATED []
synonym: "peptide uptake permease activity" RELATED []
xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium"
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
relationship: RO:0004009 CHEBI:60466 ! has primary input peptide zwitterion
creation_date: 2015-09-22T18:50:41Z

[Term]
id: GO:1904688
name: regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation
relationship: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation
creation_date: 2015-09-25T14:39:38Z

[Term]
id: GO:1904689
name: negative regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation
relationship: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation
creation_date: 2015-09-25T14:39:44Z

[Term]
id: GO:1904690
name: positive regulation of cytoplasmic translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291]
synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie]
synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002183 ! positively regulates cytoplasmic translational initiation
relationship: RO:0002213 GO:0002183 ! positively regulates cytoplasmic translational initiation
creation_date: 2015-09-25T14:39:50Z

[Term]
id: GO:1904693
name: midbrain morphogenesis
namespace: biological_process
def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "MB morphogenesis" BROAD [GOC:TermGenie]
synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain
relationship: BFO:0000050 GO:0030901 ! part of midbrain development
relationship: BFO:0000050 GO:0048854 ! part of brain morphogenesis
relationship: RO:0002298 UBERON:0001891 ! results in morphogenesis of midbrain
creation_date: 2015-09-29T09:15:28Z

[Term]
id: GO:1904697
name: regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990863 ! regulates acinar cell proliferation
relationship: RO:0002211 GO:1990863 ! regulates acinar cell proliferation
creation_date: 2015-09-30T15:19:50Z

[Term]
id: GO:1904698
name: negative regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation
relationship: RO:0002212 GO:1990863 ! negatively regulates acinar cell proliferation
creation_date: 2015-09-30T15:19:57Z

[Term]
id: GO:1904699
name: positive regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation
relationship: RO:0002213 GO:1990863 ! positively regulates acinar cell proliferation
creation_date: 2015-09-30T15:20:03Z

[Term]
id: GO:1904705
name: regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation
relationship: RO:0002211 GO:1990874 ! regulates vascular associated smooth muscle cell proliferation
creation_date: 2015-10-01T16:05:20Z

[Term]
id: GO:1904706
name: negative regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation
relationship: RO:0002212 GO:1990874 ! negatively regulates vascular associated smooth muscle cell proliferation
creation_date: 2015-10-01T16:05:26Z

[Term]
id: GO:1904707
name: positive regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation
relationship: RO:0002213 GO:1990874 ! positively regulates vascular associated smooth muscle cell proliferation
creation_date: 2015-10-01T16:05:32Z

[Term]
id: GO:1904738
name: vascular associated smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "vascular smooth muscle cell migration" EXACT []
is_a: GO:0014909 ! smooth muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000359 ! results in movement of vascular associated smooth muscle cell
relationship: RO:0002565 CL:0000359 ! results in movement of vascular associated smooth muscle cell
creation_date: 2015-10-15T09:56:00Z

[Term]
id: GO:1904745
name: Atg1/ULK1 kinase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988]
synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0065003 ! protein-containing complex assembly
created_by: dph
creation_date: 2015-10-19T12:33:08Z

[Term]
id: GO:1904746
name: negative regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development
relationship: RO:0002212 GO:1902742 ! negatively regulates apoptotic process involved in development
creation_date: 2015-10-19T14:12:27Z

[Term]
id: GO:1904747
name: positive regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development
relationship: RO:0002213 GO:1902742 ! positively regulates apoptotic process involved in development
creation_date: 2015-10-19T14:12:34Z

[Term]
id: GO:1904748
name: regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: Q10943 in PMID:22801495, inferred from mutant phenotype
synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development
relationship: RO:0002211 GO:1902742 ! regulates apoptotic process involved in development
creation_date: 2015-10-19T15:02:28Z

[Term]
id: GO:1904749
name: regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus
relationship: RO:0002211 GO:1902570 ! regulates protein localization to nucleolus
creation_date: 2015-10-19T15:16:17Z

[Term]
id: GO:1904750
name: negative regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus
relationship: RO:0002212 GO:1902570 ! negatively regulates protein localization to nucleolus
creation_date: 2015-10-19T15:16:24Z

[Term]
id: GO:1904751
name: positive regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus
relationship: RO:0002213 GO:1902570 ! positively regulates protein localization to nucleolus
creation_date: 2015-10-19T15:16:30Z

[Term]
id: GO:1904752
name: regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1904738 ! regulates vascular associated smooth muscle cell migration
relationship: RO:0002211 GO:1904738 ! regulates vascular associated smooth muscle cell migration
creation_date: 2015-10-19T15:49:52Z

[Term]
id: GO:1904753
name: negative regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1904738 ! negatively regulates vascular associated smooth muscle cell migration
relationship: RO:0002212 GO:1904738 ! negatively regulates vascular associated smooth muscle cell migration
creation_date: 2015-10-19T15:49:58Z

[Term]
id: GO:1904754
name: positive regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1904738 ! positively regulates vascular associated smooth muscle cell migration
relationship: RO:0002213 GO:1904738 ! positively regulates vascular associated smooth muscle cell migration
creation_date: 2015-10-19T15:50:05Z

[Term]
id: GO:1904770
name: intramembranous bone morphogenesis
namespace: biological_process
def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686]
synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie]
synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone
relationship: RO:0002298 UBERON:0002514 ! results in morphogenesis of intramembranous bone
creation_date: 2015-10-28T11:46:04Z

[Term]
id: GO:1904776
name: regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex
relationship: RO:0002211 GO:0072697 ! regulates protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:01Z

[Term]
id: GO:1904777
name: negative regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex
relationship: RO:0002212 GO:0072697 ! negatively regulates protein localization to cell cortex
creation_date: 2015-10-29T16:55:08Z

[Term]
id: GO:1904778
name: positive regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex
relationship: RO:0002213 GO:0072697 ! positively regulates protein localization to cell cortex
creation_date: 2015-10-29T16:55:15Z

[Term]
id: GO:1904809
name: regulation of dense core granule transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1901950 ! regulates dense core granule transport
relationship: RO:0002211 GO:1901950 ! regulates dense core granule transport
creation_date: 2015-11-11T10:40:10Z

[Term]
id: GO:1904810
name: negative regulation of dense core granule transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie]
synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1904809 ! regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1901950 ! negatively regulates dense core granule transport
relationship: RO:0002212 GO:1901950 ! negatively regulates dense core granule transport
creation_date: 2015-11-11T10:40:18Z

[Term]
id: GO:1904811
name: positive regulation of dense core granule transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897]
comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype).
synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie]
synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie]
synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1904809 ! regulation of dense core granule transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1901950 ! positively regulates dense core granule transport
relationship: RO:0002213 GO:1901950 ! positively regulates dense core granule transport
creation_date: 2015-11-11T10:40:25Z

[Term]
id: GO:1904817
name: serous membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "serosa development" RELATED [GOC:TermGenie]
synonym: "tunica serosa development" EXACT [GOC:TermGenie]
synonym: "wall of serous sac development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0000042 ! results in development of serous membrane
relationship: RO:0002296 UBERON:0000042 ! results in development of serous membrane
creation_date: 2015-11-17T19:00:01Z

[Term]
id: GO:1904818
name: visceral peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum
relationship: BFO:0000050 GO:1904820 ! part of peritoneum development
relationship: RO:0002296 UBERON:0001178 ! results in development of visceral peritoneum
creation_date: 2015-11-17T19:00:17Z

[Term]
id: GO:1904819
name: parietal peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum
relationship: BFO:0000050 GO:1904820 ! part of peritoneum development
relationship: RO:0002296 UBERON:0001366 ! results in development of parietal peritoneum
creation_date: 2015-11-17T19:00:24Z

[Term]
id: GO:1904820
name: peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritonaeum development" RELATED [GOC:TermGenie]
is_a: GO:1904817 ! serous membrane development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0002358 ! results in development of peritoneum
relationship: RO:0002296 UBERON:0002358 ! results in development of peritoneum
creation_date: 2015-11-18T17:23:51Z

[Term]
id: GO:1904821
name: chloroplast disassembly
namespace: biological_process
def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759]
comment: The disaggregation of a chloroplast into its constituent components.
synonym: "chloroplast degradation" RELATED [PMID:26494759]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0009507 ! results in disassembly of chloroplast
relationship: RO:0002590 GO:0009507 ! results in disassembly of chloroplast
creation_date: 2015-11-19T00:41:18Z

[Term]
id: GO:1904829
name: regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation
relationship: RO:0002211 GO:0035887 ! regulates aortic smooth muscle cell differentiation
creation_date: 2015-11-24T10:20:40Z

[Term]
id: GO:1904830
name: negative regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation
relationship: RO:0002212 GO:0035887 ! negatively regulates aortic smooth muscle cell differentiation
creation_date: 2015-11-24T10:20:47Z

[Term]
id: GO:1904831
name: positive regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation
relationship: RO:0002213 GO:0035887 ! positively regulates aortic smooth muscle cell differentiation
creation_date: 2015-11-24T10:20:54Z

[Term]
id: GO:1904888
name: cranial skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]
synonym: "cranial skeleton development" NARROW [GOC:TermGenie]
synonym: "craniofacial development" NARROW [PMID:11262227]
synonym: "cranium development" RELATED [GOC:TermGenie]
synonym: "osteocranium development" NARROW [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system
relationship: RO:0002296 UBERON:0010323 ! results in development of cranial skeletal system
creation_date: 2016-01-07T13:45:06Z

[Term]
id: GO:1904933
name: regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain
relationship: RO:0002211 GO:0033278 ! regulates cell proliferation in midbrain
creation_date: 2016-02-01T13:16:11Z

[Term]
id: GO:1904934
name: negative regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain
relationship: RO:0002212 GO:0033278 ! negatively regulates cell proliferation in midbrain
creation_date: 2016-02-01T13:16:19Z

[Term]
id: GO:1904935
name: positive regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain
relationship: RO:0002213 GO:0033278 ! positively regulates cell proliferation in midbrain
creation_date: 2016-02-01T13:16:27Z

[Term]
id: GO:1904936
name: interneuron migration
namespace: biological_process
def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
synonym: "inter neuron migration" EXACT [GOC:ah]
synonym: "inter-neuron migration" EXACT [GOC:ah]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000099 ! results in movement of interneuron
relationship: RO:0002565 CL:0000099 ! results in movement of interneuron
creation_date: 2016-02-01T14:04:32Z

[Term]
id: GO:1904937
name: sensory neuron migration
namespace: biological_process
def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000101 ! results in movement of sensory neuron
relationship: RO:0002565 CL:0000101 ! results in movement of sensory neuron
creation_date: 2016-02-01T14:15:50Z

[Term]
id: GO:1904942
name: regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
is_a: GO:1901210 ! regulation of cardiac chamber formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation
relationship: RO:0002211 GO:0003211 ! regulates cardiac ventricle formation
creation_date: 2016-02-02T16:37:16Z

[Term]
id: GO:1904943
name: negative regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie]
is_a: GO:1901211 ! negative regulation of cardiac chamber formation
is_a: GO:1904413 ! negative regulation of cardiac ventricle development
is_a: GO:1904942 ! regulation of cardiac ventricle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation
relationship: RO:0002212 GO:0003211 ! negatively regulates cardiac ventricle formation
creation_date: 2016-02-02T16:37:24Z

[Term]
id: GO:1904944
name: positive regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
is_a: GO:1901212 ! positive regulation of cardiac chamber formation
is_a: GO:1904942 ! regulation of cardiac ventricle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation
relationship: RO:0002213 GO:0003211 ! positively regulates cardiac ventricle formation
creation_date: 2016-02-02T16:37:31Z

[Term]
id: GO:1904948
name: midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron." [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665]
synonym: "DA neurogenesis from midbrain floor plate" EXACT [PMID:19122665]
synonym: "mDA neuron differentiation" EXACT [PMID:24287202]
synonym: "midbrain DA neurogenesis" EXACT [PMID:19122665]
synonym: "midbrain dopaminergic neuron production" EXACT [PMID:19122665]
is_a: GO:0021953 ! central nervous system neuron differentiation
is_a: GO:0071542 ! dopaminergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:2000097 ! results in acquisition of features of midbrain dopaminergic neuron
relationship: BFO:0000050 GO:0030901 ! part of midbrain development
relationship: RO:0002315 CL:2000097 ! results in acquisition of features of midbrain dopaminergic neuron
creation_date: 2016-02-04T14:38:10Z

[Term]
id: GO:1904950
name: negative regulation of establishment of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization
relationship: RO:0002212 GO:0045184 ! negatively regulates establishment of protein localization
creation_date: 2016-02-05T09:59:24Z

[Term]
id: GO:1904951
name: positive regulation of establishment of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "activation of protein positioning" NARROW [GOC:TermGenie]
synonym: "activation of protein recruitment" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0070201 ! regulation of establishment of protein localization
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization
relationship: RO:0002213 GO:0045184 ! positively regulates establishment of protein localization
creation_date: 2016-02-05T09:59:32Z

[Term]
id: GO:1904956
name: regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1904948 ! regulates midbrain dopaminergic neuron differentiation
relationship: RO:0002211 GO:1904948 ! regulates midbrain dopaminergic neuron differentiation
creation_date: 2016-02-09T12:00:21Z

[Term]
id: GO:1904957
name: negative regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "down-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "down-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "downregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "downregulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "inhibition of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "inhibition of mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "negative regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "negative regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904339 ! negative regulation of dopaminergic neuron differentiation
is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1904948 ! negatively regulates midbrain dopaminergic neuron differentiation
relationship: RO:0002212 GO:1904948 ! negatively regulates midbrain dopaminergic neuron differentiation
creation_date: 2016-02-09T12:00:29Z

[Term]
id: GO:1904958
name: positive regulation of midbrain dopaminergic neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "activation of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie]
synonym: "activation of mDA neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of midbrain DA neurogenesis" NARROW [GOC:TermGenie]
synonym: "activation of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie]
synonym: "activation of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie]
synonym: "positive regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "positive regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "up-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "up-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
synonym: "upregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie]
synonym: "upregulation of mDA neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie]
is_a: GO:1904340 ! positive regulation of dopaminergic neuron differentiation
is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1904948 ! positively regulates midbrain dopaminergic neuron differentiation
relationship: RO:0002213 GO:1904948 ! positively regulates midbrain dopaminergic neuron differentiation
creation_date: 2016-02-09T12:00:36Z

[Term]
id: GO:1904962
name: plastid to vacuole vesicle-mediated transport
namespace: biological_process
def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689]
synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie]
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0016482 ! cytosolic transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: BFO:0000066 GO:0005829 ! occurs in cytosol
intersection_of: RO:0002338 GO:0009536 ! has target start location plastid
intersection_of: RO:0002339 GO:0005773 ! has target end location vacuole
relationship: RO:0002338 GO:0009536 ! has target start location plastid
relationship: RO:0002339 GO:0005773 ! has target end location vacuole
creation_date: 2016-02-10T00:14:48Z

[Term]
id: GO:1904970
name: brush border assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409]
synonym: "brush border formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0005903 ! results in assembly of brush border
relationship: RO:0002588 GO:0005903 ! results in assembly of brush border
creation_date: 2016-02-17T00:58:30Z

[Term]
id: GO:1904983
name: glycine import into mitochondrion
namespace: biological_process
def: "The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]
synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0015816 ! glycine transport
is_a: GO:0170036 ! import into the mitochondrion
is_a: GO:1905039 ! carboxylic acid transmembrane transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
intersection_of: RO:0002339 GO:0005759 ! has target end location mitochondrial matrix
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
creation_date: 2016-02-28T21:53:44Z

[Term]
id: GO:1904987
name: regulation of endothelial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042118 ! regulates endothelial cell activation
relationship: RO:0002211 GO:0042118 ! regulates endothelial cell activation
creation_date: 2016-02-29T16:16:09Z

[Term]
id: GO:1904988
name: negative regulation of endothelial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042118 ! negatively regulates endothelial cell activation
relationship: RO:0002212 GO:0042118 ! negatively regulates endothelial cell activation
creation_date: 2016-02-29T16:16:18Z

[Term]
id: GO:1904989
name: positive regulation of endothelial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042118 ! positively regulates endothelial cell activation
relationship: RO:0002213 GO:0042118 ! positively regulates endothelial cell activation
creation_date: 2016-02-29T16:16:25Z

[Term]
id: GO:1905037
name: autophagosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024]
synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie]
synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie]
is_a: GO:0007033 ! vacuole organization
relationship: BFO:0000050 GO:0016236 ! part of macroautophagy
created_by: bf
creation_date: 2016-03-08T14:18:10Z

[Term]
id: GO:1905038
name: regulation of membrane lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280]
synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process
relationship: RO:0002211 GO:0006643 ! regulates membrane lipid metabolic process
creation_date: 2016-03-08T20:41:32Z

[Term]
id: GO:1905039
name: carboxylic acid transmembrane transport
namespace: biological_process
def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:29067 ! has primary input carboxylic acid anion
creation_date: 2016-03-09T15:33:53Z

[Term]
id: GO:1905063
name: regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation
relationship: RO:0002211 GO:0035886 ! regulates vascular associated smooth muscle cell differentiation
creation_date: 2016-03-21T11:14:53Z

[Term]
id: GO:1905064
name: negative regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation
relationship: RO:0002212 GO:0035886 ! negatively regulates vascular associated smooth muscle cell differentiation
creation_date: 2016-03-21T11:15:03Z

[Term]
id: GO:1905065
name: positive regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation
relationship: RO:0002213 GO:0035886 ! positively regulates vascular associated smooth muscle cell differentiation
creation_date: 2016-03-21T11:15:13Z

[Term]
id: GO:1905071
name: tight junction disassembly
namespace: biological_process
def: "The disaggregation of an tight junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "occluding junction disassembly" EXACT []
is_a: GO:0120193 ! tight junction organization
is_a: GO:0150147 ! cell-cell junction disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0070160 ! results in disassembly of tight junction
relationship: RO:0002590 GO:0070160 ! results in disassembly of tight junction
creation_date: 2016-03-23T12:35:08Z

[Term]
id: GO:1905073
name: regulation of tight junction disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905071 ! regulates tight junction disassembly
relationship: RO:0002211 GO:1905071 ! regulates tight junction disassembly
creation_date: 2016-03-23T19:32:51Z

[Term]
id: GO:1905074
name: negative regulation of tight junction disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "down regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie]
synonym: "inhibition of tight junction disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905073 ! regulation of tight junction disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905071 ! negatively regulates tight junction disassembly
relationship: RO:0002212 GO:1905071 ! negatively regulates tight junction disassembly
creation_date: 2016-03-23T19:33:01Z

[Term]
id: GO:1905075
name: positive regulation of tight junction disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie]
synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie]
synonym: "activation of tight junction disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of occluding junction disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "up regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of tight junction disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of tight junction disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905073 ! regulation of tight junction disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905071 ! positively regulates tight junction disassembly
relationship: RO:0002213 GO:1905071 ! positively regulates tight junction disassembly
creation_date: 2016-03-23T19:33:10Z

[Term]
id: GO:1905079
name: regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098749 ! regulates cerebellar neuron development
relationship: RO:0002211 GO:0098749 ! regulates cerebellar neuron development
creation_date: 2016-03-24T19:45:17Z

[Term]
id: GO:1905080
name: negative regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:1905079 ! regulation of cerebellar neuron development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098749 ! negatively regulates cerebellar neuron development
relationship: RO:0002212 GO:0098749 ! negatively regulates cerebellar neuron development
creation_date: 2016-03-24T19:45:26Z

[Term]
id: GO:1905081
name: positive regulation of cerebellar neuron development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159]
synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie]
synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie]
synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:1905079 ! regulation of cerebellar neuron development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098749 ! positively regulates cerebellar neuron development
relationship: RO:0002213 GO:0098749 ! positively regulates cerebellar neuron development
creation_date: 2016-03-24T19:45:35Z

[Term]
id: GO:1905082
name: regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
is_a: GO:0006448 ! regulation of translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070125 ! regulates mitochondrial translational elongation
relationship: RO:0002211 GO:0070125 ! regulates mitochondrial translational elongation
creation_date: 2016-03-25T17:37:03Z

[Term]
id: GO:1905083
name: negative regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie]
synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
is_a: GO:0045900 ! negative regulation of translational elongation
is_a: GO:0070130 ! negative regulation of mitochondrial translation
is_a: GO:1905082 ! regulation of mitochondrial translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0070125 ! negatively regulates mitochondrial translational elongation
relationship: RO:0002212 GO:0070125 ! negatively regulates mitochondrial translational elongation
creation_date: 2016-03-25T17:37:13Z

[Term]
id: GO:1905084
name: positive regulation of mitochondrial translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458]
synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie]
synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie]
is_a: GO:0045901 ! positive regulation of translational elongation
is_a: GO:1905082 ! regulation of mitochondrial translational elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0070125 ! positively regulates mitochondrial translational elongation
relationship: RO:0002213 GO:0070125 ! positively regulates mitochondrial translational elongation
creation_date: 2016-03-25T17:37:22Z

[Term]
id: GO:1905126
name: regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport
relationship: RO:0002211 GO:0099640 ! regulates axo-dendritic protein transport
creation_date: 2016-04-11T20:38:31Z

[Term]
id: GO:1905127
name: negative regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport
relationship: RO:0002212 GO:0099640 ! negatively regulates axo-dendritic protein transport
creation_date: 2016-04-11T20:38:40Z

[Term]
id: GO:1905128
name: positive regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport
relationship: RO:0002213 GO:0099640 ! positively regulates axo-dendritic protein transport
creation_date: 2016-04-11T20:38:48Z

[Term]
id: GO:1905139
name: apical ectodermal ridge formation
namespace: biological_process
def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583]
synonym: "AER formation" RELATED [GOC:TermGenie]
synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: RO:0002297 UBERON:0004356 ! results in formation of apical ectodermal ridge
relationship: BFO:0000050 GO:0035107 ! part of appendage morphogenesis
relationship: RO:0002297 UBERON:0004356 ! results in formation of apical ectodermal ridge
creation_date: 2016-04-13T11:46:40Z

[Term]
id: GO:1905140
name: regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation
relationship: RO:0002211 GO:1905139 ! regulates apical ectodermal ridge formation
creation_date: 2016-04-13T12:16:40Z

[Term]
id: GO:1905141
name: negative regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "down regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "downregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "inhibition of AER formation" RELATED [GOC:TermGenie]
synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation
relationship: RO:0002212 GO:1905139 ! negatively regulates apical ectodermal ridge formation
creation_date: 2016-04-13T12:16:48Z

[Term]
id: GO:1905142
name: positive regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "activation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "upregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation
relationship: RO:0002213 GO:1905139 ! positively regulates apical ectodermal ridge formation
creation_date: 2016-04-13T12:16:57Z

[Term]
id: GO:1905144
name: response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
relationship: RO:0004009 CHEBI:15355 ! has primary input
creation_date: 2016-04-14T08:54:49Z

[Term]
id: GO:1905145
name: cellular response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905144 ! response to acetylcholine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:15355 ! has primary input
creation_date: 2016-04-14T08:54:58Z

[Term]
id: GO:1905146
name: lysosomal protein catabolic process
namespace: biological_process
def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770]
comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants.
synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "cellular protein catabolic process in lysosome" EXACT []
synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "lysosomal protein catabolism" EXACT [GOC:bf]
synonym: "lysosomal protein degradation" EXACT [GOC:bf]
synonym: "lysosomal proteolysis" RELATED [PMID:24334770]
synonym: "proteolysis within lysosome" RELATED [GOC:bf]
is_a: GO:0007039 ! protein catabolic process in the vacuole
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: BFO:0000066 GO:0005764 ! occurs in lysosome
relationship: BFO:0000066 GO:0005764 ! occurs in lysosome
creation_date: 2016-04-14T12:50:34Z

[Term]
id: GO:1905147
name: regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy
relationship: RO:0002211 GO:0014895 ! regulates smooth muscle hypertrophy
creation_date: 2016-04-15T12:47:07Z

[Term]
id: GO:1905148
name: negative regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy
relationship: RO:0002212 GO:0014895 ! negatively regulates smooth muscle hypertrophy
creation_date: 2016-04-15T12:47:16Z

[Term]
id: GO:1905149
name: positive regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy
relationship: RO:0002213 GO:0014895 ! positively regulates smooth muscle hypertrophy
creation_date: 2016-04-15T12:47:24Z

[Term]
id: GO:1905153
name: regulation of membrane invagination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010324 ! regulates membrane invagination
relationship: RO:0002211 GO:0010324 ! regulates membrane invagination
created_by: bf
creation_date: 2016-04-18T15:43:54Z

[Term]
id: GO:1905154
name: negative regulation of membrane invagination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010324 ! negatively regulates membrane invagination
relationship: RO:0002212 GO:0010324 ! negatively regulates membrane invagination
creation_date: 2016-04-18T15:44:04Z

[Term]
id: GO:1905155
name: positive regulation of membrane invagination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of membrane invagination" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010324 ! positively regulates membrane invagination
relationship: RO:0002213 GO:0010324 ! positively regulates membrane invagination
creation_date: 2016-04-18T15:44:12Z

[Term]
id: GO:1905165
name: regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937]
synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905146 ! regulates lysosomal protein catabolic process
relationship: RO:0002211 GO:1905146 ! regulates lysosomal protein catabolic process
creation_date: 2016-04-26T12:10:01Z

[Term]
id: GO:1905166
name: negative regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole
is_a: GO:1905165 ! regulation of lysosomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905146 ! negatively regulates lysosomal protein catabolic process
relationship: RO:0002212 GO:1905146 ! negatively regulates lysosomal protein catabolic process
creation_date: 2016-04-26T12:10:10Z

[Term]
id: GO:1905167
name: positive regulation of lysosomal protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie]
synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie]
is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole
is_a: GO:1905165 ! regulation of lysosomal protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905146 ! positively regulates lysosomal protein catabolic process
relationship: RO:0002213 GO:1905146 ! positively regulates lysosomal protein catabolic process
creation_date: 2016-04-26T12:10:19Z

[Term]
id: GO:1905192
name: regulation of chloroplast fission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170]
comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments.
synonym: "regulation of chloroplast division" EXACT [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010020 ! regulates chloroplast fission
relationship: RO:0002211 GO:0010020 ! regulates chloroplast fission
creation_date: 2016-05-10T19:07:34Z

[Term]
id: GO:1905193
name: negative regulation of chloroplast fission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170]
comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments.
synonym: "down regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "down regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "down-regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "down-regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "downregulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "downregulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "inhibition of chloroplast division" NARROW [GOC:TermGenie]
synonym: "inhibition of chloroplast fission" NARROW [GOC:TermGenie]
synonym: "negative regulation of chloroplast division" EXACT [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905192 ! regulation of chloroplast fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010020 ! negatively regulates chloroplast fission
relationship: RO:0002212 GO:0010020 ! negatively regulates chloroplast fission
creation_date: 2016-05-10T19:07:43Z

[Term]
id: GO:1905194
name: positive regulation of chloroplast fission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170]
comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments.
synonym: "activation of chloroplast division" NARROW [GOC:TermGenie]
synonym: "activation of chloroplast fission" NARROW [GOC:TermGenie]
synonym: "positive regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "up regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "up-regulation of chloroplast fission" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast division" EXACT [GOC:TermGenie]
synonym: "upregulation of chloroplast fission" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1905192 ! regulation of chloroplast fission
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010020 ! positively regulates chloroplast fission
relationship: RO:0002213 GO:0010020 ! positively regulates chloroplast fission
creation_date: 2016-05-10T19:07:51Z

[Term]
id: GO:1905207
name: regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation
relationship: RO:0002211 GO:0035051 ! regulates cardiocyte differentiation
creation_date: 2016-06-02T07:20:01Z

[Term]
id: GO:1905208
name: negative regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation
relationship: RO:0002212 GO:0035051 ! negatively regulates cardiocyte differentiation
creation_date: 2016-06-02T07:20:09Z

[Term]
id: GO:1905209
name: positive regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation
relationship: RO:0002213 GO:0035051 ! positively regulates cardiocyte differentiation
creation_date: 2016-06-02T07:20:16Z

[Term]
id: GO:1905213
name: negative regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1902340 ! negative regulation of chromosome condensation
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation
relationship: RO:0002212 GO:0007076 ! negatively regulates mitotic chromosome condensation
creation_date: 2016-06-03T08:41:08Z

[Term]
id: GO:1905216
name: positive regulation of RNA binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]
subset: gocheck_do_not_annotate
synonym: "activation of RNA binding" NARROW [GOC:TermGenie]
synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie]
is_a: GO:0051099 ! positive regulation of binding
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003723 ! positively regulates RNA binding
relationship: RO:0002213 GO:0003723 ! positively regulates RNA binding
creation_date: 2016-06-06T10:21:12Z

[Term]
id: GO:1905223
name: epicardium morphogenesis
namespace: biological_process
def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie]
synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie]
synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie]
synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium
relationship: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium
creation_date: 2016-06-07T10:02:32Z

[Term]
id: GO:1905232
name: cellular response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137]
synonym: "cellular response to L-glutamate(1-)" RELATED []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902065 ! response to L-glutamate
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:29985 ! has primary input
creation_date: 2016-06-07T17:30:08Z

[Term]
id: GO:1905268
name: negative regulation of chromatin organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]
synonym: "down regulation of chromatin assembly or disassembly" RELATED []
synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin assembly or disassembly" RELATED []
synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin assembly or disassembly" RELATED []
synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "inhibition of chromatin assembly or disassembly" NARROW []
synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromatin assembly or disassembly" RELATED []
synonym: "negative regulation of chromatin assembly/disassembly" EXACT []
synonym: "negative regulation of chromatin modification" RELATED []
synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1902275 ! regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006325 ! negatively regulates chromatin organization
relationship: RO:0002212 GO:0006325 ! negatively regulates chromatin organization
creation_date: 2016-06-15T20:14:47Z

[Term]
id: GO:1905269
name: positive regulation of chromatin organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]
synonym: "activation of chromatin assembly or disassembly" NARROW []
synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie]
synonym: "activation of chromatin organization" NARROW [GOC:TermGenie]
synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromatin assembly or disassembly" RELATED []
synonym: "positive regulation of chromatin assembly/disassembly" RELATED []
synonym: "positive regulation of chromatin modification" RELATED []
synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "stimulation of chromatin assembly or disassembly" NARROW []
synonym: "up regulation of chromatin assembly or disassembly" RELATED []
synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin assembly or disassembly" RELATED []
synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin assembly or disassembly" EXACT []
synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:1902275 ! regulation of chromatin organization
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006325 ! positively regulates chromatin organization
relationship: RO:0002213 GO:0006325 ! positively regulates chromatin organization
creation_date: 2016-06-15T20:14:56Z

[Term]
id: GO:1905276
name: regulation of epithelial tube formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072175 ! regulates epithelial tube formation
relationship: RO:0002211 GO:0072175 ! regulates epithelial tube formation
creation_date: 2016-06-20T09:35:41Z

[Term]
id: GO:1905277
name: negative regulation of epithelial tube formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation
relationship: RO:0002212 GO:0072175 ! negatively regulates epithelial tube formation
creation_date: 2016-06-20T09:35:49Z

[Term]
id: GO:1905278
name: positive regulation of epithelial tube formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation
relationship: RO:0002213 GO:0072175 ! positively regulates epithelial tube formation
creation_date: 2016-06-20T09:35:57Z

[Term]
id: GO:1905288
name: vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034390 ! smooth muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell
relationship: BFO:0000066 CL:0000359 ! occurs in vascular associated smooth muscle cell
creation_date: 2016-06-23T13:24:20Z

[Term]
id: GO:1905292
name: regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation
relationship: RO:0002211 GO:0014033 ! regulates neural crest cell differentiation
creation_date: 2016-06-28T15:02:01Z

[Term]
id: GO:1905293
name: negative regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905292 ! regulation of neural crest cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation
relationship: RO:0002212 GO:0014033 ! negatively regulates neural crest cell differentiation
creation_date: 2016-06-28T15:02:09Z

[Term]
id: GO:1905294
name: positive regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905292 ! regulation of neural crest cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation
relationship: RO:0002213 GO:0014033 ! positively regulates neural crest cell differentiation
creation_date: 2016-06-28T15:02:16Z

[Term]
id: GO:1905304
name: regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0110020 ! regulation of actomyosin structure organization
is_a: GO:1902115 ! regulation of organelle assembly
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly
relationship: RO:0002211 GO:0055003 ! regulates cardiac myofibril assembly
creation_date: 2016-07-06T10:01:49Z

[Term]
id: GO:1905305
name: negative regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1905304 ! regulation of cardiac myofibril assembly
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly
relationship: RO:0002212 GO:0055003 ! negatively regulates cardiac myofibril assembly
creation_date: 2016-07-06T10:01:58Z

[Term]
id: GO:1905306
name: positive regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie]
synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie]
synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
is_a: GO:1905304 ! regulation of cardiac myofibril assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly
relationship: RO:0002213 GO:0055003 ! positively regulates cardiac myofibril assembly
creation_date: 2016-07-06T10:02:07Z

[Term]
id: GO:1905310
name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003253 ! regulates cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: RO:0002211 GO:0003253 ! regulates cardiac neural crest cell migration involved in outflow tract morphogenesis
creation_date: 2016-07-11T17:34:26Z

[Term]
id: GO:1905311
name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0003253 ! negatively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: RO:0002212 GO:0003253 ! negatively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis
creation_date: 2016-07-11T17:34:35Z

[Term]
id: GO:1905312
name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003253 ! positively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: RO:0002213 GO:0003253 ! positively regulates cardiac neural crest cell migration involved in outflow tract morphogenesis
creation_date: 2016-07-11T17:34:43Z

[Term]
id: GO:1905315
name: cell proliferation involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis
creation_date: 2016-07-12T13:56:36Z

[Term]
id: GO:1905319
name: mesenchymal stem cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000134 ! results in movement of mesenchymal stem cell
relationship: RO:0002565 CL:0000134 ! results in movement of mesenchymal stem cell
creation_date: 2016-07-14T17:13:02Z

[Term]
id: GO:1905320
name: regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905319 ! regulates mesenchymal stem cell migration
relationship: RO:0002211 GO:1905319 ! regulates mesenchymal stem cell migration
creation_date: 2016-07-15T22:19:14Z

[Term]
id: GO:1905321
name: negative regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1905320 ! regulation of mesenchymal stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905319 ! negatively regulates mesenchymal stem cell migration
relationship: RO:0002212 GO:1905319 ! negatively regulates mesenchymal stem cell migration
creation_date: 2016-07-15T22:19:22Z

[Term]
id: GO:1905322
name: positive regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1905320 ! regulation of mesenchymal stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905319 ! positively regulates mesenchymal stem cell migration
relationship: RO:0002213 GO:1905319 ! positively regulates mesenchymal stem cell migration
creation_date: 2016-07-15T22:19:29Z

[Term]
id: GO:1905330
name: regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium
relationship: RO:0002211 GO:0002009 ! regulates morphogenesis of an epithelium
creation_date: 2016-07-22T07:13:49Z

[Term]
id: GO:1905331
name: negative regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium
relationship: RO:0002212 GO:0002009 ! negatively regulates morphogenesis of an epithelium
creation_date: 2016-07-22T07:13:57Z

[Term]
id: GO:1905332
name: positive regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium
relationship: RO:0002213 GO:0002009 ! positively regulates morphogenesis of an epithelium
creation_date: 2016-07-22T07:14:05Z

[Term]
id: GO:1905349
name: ciliary transition zone assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032]
synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie]
synonym: "cilial transition zone formation" EXACT [GOC:TermGenie]
synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie]
synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie]
synonym: "cilium transition zone formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone
relationship: BFO:0000050 GO:0060271 ! part of cilium assembly
relationship: RO:0002588 GO:0035869 ! results in assembly of ciliary transition zone
creation_date: 2016-08-04T14:49:43Z

[Term]
id: GO:1905383
name: protein localization to presynapse
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494]
synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494]
is_a: GO:0035418 ! protein localization to synapse
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse
relationship: RO:0002339 GO:0098793 ! has target end location presynapse
creation_date: 2016-08-18T14:42:59Z

[Term]
id: GO:1905384
name: regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905383 ! regulates protein localization to presynapse
relationship: RO:0002211 GO:1905383 ! regulates protein localization to presynapse
creation_date: 2016-08-18T14:56:00Z

[Term]
id: GO:1905385
name: negative regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905384 ! regulation of protein localization to presynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse
relationship: RO:0002212 GO:1905383 ! negatively regulates protein localization to presynapse
creation_date: 2016-08-18T14:56:08Z

[Term]
id: GO:1905386
name: positive regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie]
synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1902474 ! positive regulation of protein localization to synapse
is_a: GO:1905384 ! regulation of protein localization to presynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse
relationship: RO:0002213 GO:1905383 ! positively regulates protein localization to presynapse
creation_date: 2016-08-18T14:56:21Z

[Term]
id: GO:1905429
name: response to glycine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164]
synonym: "response to aminoacetic acid" EXACT []
synonym: "response to aminoethanoic acid" EXACT []
synonym: "response to Gly" EXACT []
synonym: "response to glycin" EXACT []
is_a: GO:0043200 ! response to amino acid
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
relationship: RO:0004009 CHEBI:57305 ! has primary input
creation_date: 2016-09-08T22:09:15Z

[Term]
id: GO:1905430
name: cellular response to glycine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164]
synonym: "cellular response to aminoacetic acid" EXACT []
synonym: "cellular response to aminoethanoic acid" EXACT []
synonym: "cellular response to Gly" EXACT []
synonym: "cellular response to glycin" EXACT []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905429 ! response to glycine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:57305 ! has primary input
creation_date: 2016-09-08T22:09:23Z

[Term]
id: GO:1905432
name: regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0099177 ! regulation of trans-synaptic signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide
relationship: RO:0002211 GO:0099082 ! regulates retrograde trans-synaptic signaling by neuropeptide
creation_date: 2016-09-14T10:56:47Z

[Term]
id: GO:1905433
name: negative regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide
relationship: RO:0002212 GO:0099082 ! negatively regulates retrograde trans-synaptic signaling by neuropeptide
creation_date: 2016-09-14T10:56:55Z

[Term]
id: GO:1905434
name: positive regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide
relationship: RO:0002213 GO:0099082 ! positively regulates retrograde trans-synaptic signaling by neuropeptide
creation_date: 2016-09-14T10:57:02Z

[Term]
id: GO:1905453
name: regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation
relationship: RO:0002211 GO:0002318 ! regulates myeloid progenitor cell differentiation
creation_date: 2016-09-16T12:32:18Z

[Term]
id: GO:1905454
name: negative regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation
relationship: RO:0002212 GO:0002318 ! negatively regulates myeloid progenitor cell differentiation
creation_date: 2016-09-16T12:32:26Z

[Term]
id: GO:1905455
name: positive regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation
relationship: RO:0002213 GO:0002318 ! positively regulates myeloid progenitor cell differentiation
creation_date: 2016-09-16T12:32:33Z

[Term]
id: GO:1905456
name: regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002320 ! regulates lymphoid progenitor cell differentiation
relationship: RO:0002211 GO:0002320 ! regulates lymphoid progenitor cell differentiation
creation_date: 2016-09-16T12:32:40Z

[Term]
id: GO:1905457
name: negative regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002320 ! negatively regulates lymphoid progenitor cell differentiation
relationship: RO:0002212 GO:0002320 ! negatively regulates lymphoid progenitor cell differentiation
creation_date: 2016-09-16T12:32:48Z

[Term]
id: GO:1905458
name: positive regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002320 ! positively regulates lymphoid progenitor cell differentiation
relationship: RO:0002213 GO:0002320 ! positively regulates lymphoid progenitor cell differentiation
creation_date: 2016-09-16T12:32:55Z

[Term]
id: GO:1905459
name: regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process
relationship: RO:0002211 GO:1905288 ! regulates vascular associated smooth muscle cell apoptotic process
creation_date: 2016-09-19T11:33:54Z

[Term]
id: GO:1905460
name: negative regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process
is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process
relationship: RO:0002212 GO:1905288 ! negatively regulates vascular associated smooth muscle cell apoptotic process
creation_date: 2016-09-19T11:34:03Z

[Term]
id: GO:1905461
name: positive regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process
is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process
relationship: RO:0002213 GO:1905288 ! positively regulates vascular associated smooth muscle cell apoptotic process
creation_date: 2016-09-19T11:34:10Z

[Term]
id: GO:1905475
name: regulation of protein localization to membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072657 ! regulates protein localization to membrane
relationship: RO:0002211 GO:0072657 ! regulates protein localization to membrane
created_by: bc
creation_date: 2016-09-21T16:20:03Z

[Term]
id: GO:1905476
name: negative regulation of protein localization to membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane
relationship: RO:0002212 GO:0072657 ! negatively regulates protein localization to membrane
creation_date: 2016-09-21T16:20:10Z

[Term]
id: GO:1905477
name: positive regulation of protein localization to membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane
relationship: RO:0002213 GO:0072657 ! positively regulates protein localization to membrane
creation_date: 2016-09-21T16:20:18Z

[Term]
id: GO:1905483
name: regulation of motor neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097475 ! regulates motor neuron migration
relationship: RO:0002211 GO:0097475 ! regulates motor neuron migration
creation_date: 2016-09-23T12:49:54Z

[Term]
id: GO:1905484
name: negative regulation of motor neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie]
is_a: GO:1905483 ! regulation of motor neuron migration
is_a: GO:2001223 ! negative regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097475 ! negatively regulates motor neuron migration
relationship: RO:0002212 GO:0097475 ! negatively regulates motor neuron migration
creation_date: 2016-09-23T12:50:11Z

[Term]
id: GO:1905485
name: positive regulation of motor neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie]
synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie]
is_a: GO:1905483 ! regulation of motor neuron migration
is_a: GO:2001224 ! positive regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097475 ! positively regulates motor neuron migration
relationship: RO:0002213 GO:0097475 ! positively regulates motor neuron migration
creation_date: 2016-09-23T12:50:19Z

[Term]
id: GO:1905492
name: positive regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie]
synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve
relationship: RO:0002213 GO:0048755 ! positively regulates branching morphogenesis of a nerve
creation_date: 2016-09-23T14:11:52Z

[Term]
id: GO:1905503
name: regulation of motile cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "regulation of motile primary cilium assembly" RELATED []
synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:1902017 ! regulation of cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044458 ! regulates motile cilium assembly
relationship: RO:0002211 GO:0044458 ! regulates motile cilium assembly
creation_date: 2016-09-27T18:27:47Z

[Term]
id: GO:1905504
name: negative regulation of motile cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilium assembly" RELATED []
synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:1902018 ! negative regulation of cilium assembly
is_a: GO:1905503 ! regulation of motile cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0044458 ! negatively regulates motile cilium assembly
relationship: RO:0002212 GO:0044458 ! negatively regulates motile cilium assembly
creation_date: 2016-09-27T18:27:55Z

[Term]
id: GO:1905505
name: positive regulation of motile cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie]
synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilium assembly" RELATED []
synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0045724 ! positive regulation of cilium assembly
is_a: GO:1905503 ! regulation of motile cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0044458 ! positively regulates motile cilium assembly
relationship: RO:0002213 GO:0044458 ! positively regulates motile cilium assembly
creation_date: 2016-09-27T18:28:03Z

[Term]
id: GO:1905516
name: positive regulation of fertilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576]
synonym: "activation of fertilization" NARROW [GOC:TermGenie]
synonym: "activation of syngamy" NARROW [GOC:TermGenie]
synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "up regulation of fertilization" EXACT [GOC:TermGenie]
synonym: "up regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "upregulation of fertilization" EXACT [GOC:TermGenie]
synonym: "upregulation of syngamy" EXACT [GOC:TermGenie]
is_a: GO:0080154 ! regulation of fertilization
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0009566 ! positively regulates fertilization
relationship: RO:0002213 GO:0009566 ! positively regulates fertilization
creation_date: 2016-09-30T14:32:32Z

[Term]
id: GO:1905517
name: macrophage migration
namespace: biological_process
def: "The orderly movement of a macrophage from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:25749876]
is_a: GO:0071674 ! mononuclear cell migration
is_a: GO:0097529 ! myeloid leukocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000235 ! results in movement of macrophage
relationship: RO:0002565 CL:0000235 ! results in movement of macrophage
creation_date: 2016-09-30T22:17:45Z

[Term]
id: GO:1905521
name: regulation of macrophage migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1905517 ! regulates macrophage migration
relationship: RO:0002211 GO:1905517 ! regulates macrophage migration
creation_date: 2016-10-03T15:29:06Z

[Term]
id: GO:1905522
name: negative regulation of macrophage migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
synonym: "down regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "downregulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "inhibition of macrophage migration" NARROW [GOC:TermGenie]
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:1905521 ! regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1905517 ! negatively regulates macrophage migration
relationship: RO:0002212 GO:1905517 ! negatively regulates macrophage migration
creation_date: 2016-10-03T15:29:14Z

[Term]
id: GO:1905523
name: positive regulation of macrophage migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876]
synonym: "activation of macrophage migration" NARROW [GOC:TermGenie]
synonym: "up regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of macrophage migration" EXACT [GOC:TermGenie]
synonym: "upregulation of macrophage migration" EXACT [GOC:TermGenie]
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:1905521 ! regulation of macrophage migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1905517 ! positively regulates macrophage migration
relationship: RO:0002213 GO:1905517 ! positively regulates macrophage migration
creation_date: 2016-10-03T15:29:21Z

[Term]
id: GO:1905553
name: regulation of blood vessel branching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis
relationship: RO:0002211 GO:0001569 ! regulates branching involved in blood vessel morphogenesis
creation_date: 2016-10-12T14:19:33Z

[Term]
id: GO:1905554
name: negative regulation of blood vessel branching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
is_a: GO:1905553 ! regulation of blood vessel branching
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis
relationship: RO:0002212 GO:0001569 ! negatively regulates branching involved in blood vessel morphogenesis
creation_date: 2016-10-12T14:19:41Z

[Term]
id: GO:1905555
name: positive regulation of blood vessel branching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:1905553 ! regulation of blood vessel branching
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis
relationship: RO:0002213 GO:0001569 ! positively regulates branching involved in blood vessel morphogenesis
creation_date: 2016-10-12T14:19:49Z

[Term]
id: GO:1905557
name: regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
is_a: GO:0010549 ! regulation of membrane disassembly
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly
relationship: RO:0002211 GO:0007077 ! regulates mitotic nuclear membrane disassembly
creation_date: 2016-10-14T13:14:57Z

[Term]
id: GO:1905558
name: negative regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly
relationship: RO:0002212 GO:0007077 ! negatively regulates mitotic nuclear membrane disassembly
creation_date: 2016-10-14T13:15:08Z

[Term]
id: GO:1905559
name: positive regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly
relationship: RO:0002213 GO:0007077 ! positively regulates mitotic nuclear membrane disassembly
creation_date: 2016-10-14T13:15:17Z

[Term]
id: GO:1905562
name: regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
is_a: GO:0001936 ! regulation of endothelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation
relationship: RO:0002211 GO:0101023 ! regulates vascular endothelial cell proliferation
creation_date: 2016-10-17T09:24:17Z

[Term]
id: GO:1905563
name: negative regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0001937 ! negative regulation of endothelial cell proliferation
is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation
relationship: RO:0002212 GO:0101023 ! negatively regulates vascular endothelial cell proliferation
creation_date: 2016-10-17T09:24:26Z

[Term]
id: GO:1905564
name: positive regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0001938 ! positive regulation of endothelial cell proliferation
is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation
relationship: RO:0002213 GO:0101023 ! positively regulates vascular endothelial cell proliferation
creation_date: 2016-10-17T09:24:35Z

[Term]
id: GO:1905606
name: regulation of presynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
subset: goslim_synapse
synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099174 ! regulation of presynapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0099054 ! regulates presynapse assembly
relationship: RO:0002211 GO:0099054 ! regulates presynapse assembly
creation_date: 2016-10-27T16:08:13Z

[Term]
id: GO:1905607
name: negative regulation of presynapse assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1905606 ! regulation of presynapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly
relationship: RO:0002212 GO:0099054 ! negatively regulates presynapse assembly
creation_date: 2016-10-27T16:08:20Z

[Term]
id: GO:1905608
name: positive regulation of presynapse assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie]
synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905606 ! regulation of presynapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0099054 ! positively regulates presynapse assembly
relationship: RO:0002213 GO:0099054 ! positively regulates presynapse assembly
creation_date: 2016-10-27T16:08:28Z

[Term]
id: GO:1905627
name: regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process
relationship: RO:0002211 GO:0042427 ! regulates serotonin biosynthetic process
creation_date: 2016-10-31T14:26:20Z

[Term]
id: GO:1905628
name: negative regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1905627 ! regulation of serotonin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process
relationship: RO:0002212 GO:0042427 ! negatively regulates serotonin biosynthetic process
creation_date: 2016-10-31T14:26:28Z

[Term]
id: GO:1905629
name: positive regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of serotonin formation" NARROW [GOC:TermGenie]
synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1905627 ! regulation of serotonin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process
relationship: RO:0002213 GO:0042427 ! positively regulates serotonin biosynthetic process
creation_date: 2016-10-31T14:26:36Z

[Term]
id: GO:1905632
name: protein localization to euchromatin
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714]
synonym: "protein localisation in euchromatin" EXACT [GOC:TermGenie]
synonym: "protein localisation to euchromatin" EXACT [GOC:TermGenie]
synonym: "protein localization in euchromatin" EXACT [GOC:TermGenie]
is_a: GO:0071168 ! protein localization to chromatin
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0000791 ! has target end location euchromatin
relationship: RO:0002339 GO:0000791 ! has target end location euchromatin
creation_date: 2016-11-01T16:16:14Z

[Term]
id: GO:1905633
name: establishment of protein localization to euchromatin
namespace: biological_process
def: "The directed movement of a protein to a specific location in an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714]
synonym: "establishment of protein localisation in euchromatin" EXACT [GOC:TermGenie]
synonym: "establishment of protein localisation to euchromatin" EXACT [GOC:TermGenie]
synonym: "establishment of protein localization in euchromatin" EXACT [GOC:TermGenie]
is_a: GO:0071169 ! establishment of protein localization to chromatin
is_a: GO:1905632 ! protein localization to euchromatin
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: RO:0002339 GO:0000791 ! has target end location euchromatin
creation_date: 2016-11-01T16:16:22Z

[Term]
id: GO:1905634
name: regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]
synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071168 ! regulates protein localization to chromatin
relationship: RO:0002211 GO:0071168 ! regulates protein localization to chromatin
creation_date: 2016-11-01T16:33:52Z

[Term]
id: GO:1905651
name: regulation of artery morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048844 ! regulates artery morphogenesis
relationship: RO:0002211 GO:0048844 ! regulates artery morphogenesis
creation_date: 2016-11-09T12:19:37Z

[Term]
id: GO:1905652
name: negative regulation of artery morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie]
is_a: GO:1905651 ! regulation of artery morphogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis
relationship: RO:0002212 GO:0048844 ! negatively regulates artery morphogenesis
creation_date: 2016-11-09T12:19:53Z

[Term]
id: GO:1905653
name: positive regulation of artery morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie]
synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905651 ! regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis
relationship: RO:0002213 GO:0048844 ! positively regulates artery morphogenesis
creation_date: 2016-11-09T12:20:01Z

[Term]
id: GO:1905671
name: regulation of lysosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470]
synonym: "regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007040 ! regulates lysosome organization
relationship: RO:0002211 GO:0007040 ! regulates lysosome organization
creation_date: 2016-11-11T22:01:04Z

[Term]
id: GO:1905672
name: negative regulation of lysosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470]
synonym: "down regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "down regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "downregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of lysosome organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosome organization" NARROW [GOC:TermGenie]
synonym: "inhibition of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1905671 ! regulation of lysosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007040 ! negatively regulates lysosome organization
relationship: RO:0002212 GO:0007040 ! negatively regulates lysosome organization
creation_date: 2016-11-11T22:01:12Z

[Term]
id: GO:1905673
name: positive regulation of lysosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470]
synonym: "activation of lysosome organisation" NARROW [GOC:TermGenie]
synonym: "activation of lysosome organization" NARROW [GOC:TermGenie]
synonym: "activation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "up regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of lysosome organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosome organization" EXACT [GOC:TermGenie]
synonym: "upregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0044090 ! positive regulation of vacuole organization
is_a: GO:1905671 ! regulation of lysosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007040 ! positively regulates lysosome organization
relationship: RO:0002213 GO:0007040 ! positively regulates lysosome organization
creation_date: 2016-11-11T22:01:20Z

[Term]
id: GO:1905690
name: nucleus disassembly
namespace: biological_process
def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]
synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie]
is_a: GO:0006997 ! nucleus organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: RO:0002590 GO:0005634 ! results in disassembly of nucleus
relationship: RO:0002590 GO:0005634 ! results in disassembly of nucleus
created_by: pr
creation_date: 2016-11-14T13:38:57Z

[Term]
id: GO:1905720
name: cytoplasmic microtubule bundle
namespace: cellular_component
def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291]
synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie]
synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie]
is_a: GO:0097427 ! microtubule bundle
intersection_of: GO:0097427 ! microtubule bundle
intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm
relationship: BFO:0000050 GO:0005737 ! part of cytoplasm
creation_date: 2016-11-24T16:52:02Z

[Term]
id: GO:1905755
name: protein localization to cytoplasmic microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031]
synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule
relationship: RO:0002339 GO:0005881 ! has target end location cytoplasmic microtubule
creation_date: 2016-12-12T15:31:07Z

[Term]
id: GO:1905770
name: regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation
relationship: RO:0002211 GO:0048333 ! regulates mesodermal cell differentiation
creation_date: 2016-12-21T12:44:13Z

[Term]
id: GO:1905771
name: negative regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation
relationship: RO:0002212 GO:0048333 ! negatively regulates mesodermal cell differentiation
creation_date: 2016-12-21T12:44:23Z

[Term]
id: GO:1905772
name: positive regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation
relationship: RO:0002213 GO:0048333 ! positively regulates mesodermal cell differentiation
creation_date: 2016-12-21T12:44:32Z

[Term]
id: GO:1905806
name: regulation of synapse pruning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
subset: goslim_synapse
synonym: "regulation of synapse clearance" EXACT []
synonym: "regulation of synapse elimination" EXACT []
synonym: "regulation of synapse removal" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0098883 ! regulates synapse pruning
relationship: RO:0002211 GO:0098883 ! regulates synapse pruning
creation_date: 2017-01-11T22:03:15Z

[Term]
id: GO:1905807
name: negative regulation of synapse pruning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
is_a: GO:1905806 ! regulation of synapse pruning
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0098883 ! negatively regulates synapse pruning
relationship: RO:0002212 GO:0098883 ! negatively regulates synapse pruning
creation_date: 2017-01-11T22:03:24Z

[Term]
id: GO:1905808
name: positive regulation of synapse pruning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905806 ! regulation of synapse pruning
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098883 ! positively regulates synapse pruning
relationship: RO:0002213 GO:0098883 ! positively regulates synapse pruning
creation_date: 2017-01-11T22:03:33Z

[Term]
id: GO:1905809
name: negative regulation of synapse organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of synapse development" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of synapse development" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0050808 ! negatively regulates synapse organization
relationship: RO:0002212 GO:0050808 ! negatively regulates synapse organization
creation_date: 2017-01-11T22:03:41Z

[Term]
id: GO:1905821
name: positive regulation of chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547]
synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0030261 ! positively regulates chromosome condensation
relationship: RO:0002213 GO:0030261 ! positively regulates chromosome condensation
creation_date: 2017-01-13T14:13:44Z

[Term]
id: GO:1905833
name: negative regulation of microtubule nucleation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799]
synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031115 ! negative regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation
relationship: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleation
creation_date: 2017-01-17T12:00:56Z

[Term]
id: GO:1905864
name: regulation of Atg1/ULK1 kinase complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215]
synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie]
synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1904745 ! regulates Atg1/ULK1 kinase complex assembly
relationship: RO:0002211 GO:1904745 ! regulates Atg1/ULK1 kinase complex assembly
created_by: pr
creation_date: 2017-01-26T13:23:26Z

[Term]
id: GO:1905871
name: regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge
relationship: RO:0002211 GO:1902463 ! regulates protein localization to cell leading edge
creation_date: 2017-01-27T19:34:55Z

[Term]
id: GO:1905872
name: negative regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905871 ! regulation of protein localization to cell leading edge
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge
relationship: RO:0002212 GO:1902463 ! negatively regulates protein localization to cell leading edge
creation_date: 2017-01-27T19:35:04Z

[Term]
id: GO:1905873
name: positive regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905871 ! regulation of protein localization to cell leading edge
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge
relationship: RO:0002213 GO:1902463 ! positively regulates protein localization to cell leading edge
creation_date: 2017-01-27T19:35:13Z

[Term]
id: GO:1905879
name: regulation of oogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "regulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048477 ! regulates oogenesis
relationship: RO:0002211 GO:0048477 ! regulates oogenesis
creation_date: 2017-01-31T09:31:05Z

[Term]
id: GO:1905880
name: negative regulation of oogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ovum development" EXACT [GOC:TermGenie]
synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ovum development" NARROW [GOC:TermGenie]
synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905879 ! regulation of oogenesis
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048477 ! negatively regulates oogenesis
relationship: RO:0002212 GO:0048477 ! negatively regulates oogenesis
creation_date: 2017-01-31T09:31:15Z

[Term]
id: GO:1905881
name: positive regulation of oogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "activation of oogenesis" NARROW [GOC:TermGenie]
synonym: "activation of ovum development" NARROW [GOC:TermGenie]
synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905879 ! regulation of oogenesis
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048477 ! positively regulates oogenesis
relationship: RO:0002213 GO:0048477 ! positively regulates oogenesis
creation_date: 2017-01-31T09:31:23Z

[Term]
id: GO:1905899
name: regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development
relationship: RO:0002211 GO:0048745 ! regulates smooth muscle tissue development
creation_date: 2017-02-01T14:31:16Z

[Term]
id: GO:1905900
name: negative regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:1901862 ! negative regulation of muscle tissue development
is_a: GO:1905899 ! regulation of smooth muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development
relationship: RO:0002212 GO:0048745 ! negatively regulates smooth muscle tissue development
creation_date: 2017-02-01T14:31:24Z

[Term]
id: GO:1905901
name: positive regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:1901863 ! positive regulation of muscle tissue development
is_a: GO:1905899 ! regulation of smooth muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development
relationship: RO:0002213 GO:0048745 ! positively regulates smooth muscle tissue development
creation_date: 2017-02-01T14:31:33Z

[Term]
id: GO:1905902
name: regulation of mesoderm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0001707 ! regulates mesoderm formation
relationship: RO:0002211 GO:0001707 ! regulates mesoderm formation
creation_date: 2017-02-03T12:28:20Z

[Term]
id: GO:1905903
name: negative regulation of mesoderm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie]
is_a: GO:1905902 ! regulation of mesoderm formation
is_a: GO:2000381 ! negative regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation
relationship: RO:0002212 GO:0001707 ! negatively regulates mesoderm formation
creation_date: 2017-02-03T12:28:29Z

[Term]
id: GO:1905904
name: positive regulation of mesoderm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie]
synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie]
is_a: GO:1905902 ! regulation of mesoderm formation
is_a: GO:2000382 ! positive regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0001707 ! positively regulates mesoderm formation
relationship: RO:0002213 GO:0001707 ! positively regulates mesoderm formation
creation_date: 2017-02-03T12:28:38Z

[Term]
id: GO:1905921
name: regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process
relationship: RO:0002211 GO:0008292 ! regulates acetylcholine biosynthetic process
creation_date: 2017-02-08T13:08:30Z

[Term]
id: GO:1905922
name: negative regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process
relationship: RO:0002212 GO:0008292 ! negatively regulates acetylcholine biosynthetic process
creation_date: 2017-02-08T13:08:39Z

[Term]
id: GO:1905923
name: positive regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process
relationship: RO:0002213 GO:0008292 ! positively regulates acetylcholine biosynthetic process
creation_date: 2017-02-08T13:08:48Z

[Term]
id: GO:1905936
name: regulation of germ cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0036093 ! regulates germ cell proliferation
relationship: RO:0002211 GO:0036093 ! regulates germ cell proliferation
creation_date: 2017-02-09T14:51:31Z

[Term]
id: GO:1905937
name: negative regulation of germ cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905936 ! regulation of germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation
relationship: RO:0002212 GO:0036093 ! negatively regulates germ cell proliferation
creation_date: 2017-02-09T14:51:41Z

[Term]
id: GO:1905938
name: positive regulation of germ cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905936 ! regulation of germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation
relationship: RO:0002213 GO:0036093 ! positively regulates germ cell proliferation
creation_date: 2017-02-09T14:51:51Z

[Term]
id: GO:1905939
name: regulation of gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008406 ! regulates gonad development
relationship: RO:0002211 GO:0008406 ! regulates gonad development
creation_date: 2017-02-09T17:01:50Z

[Term]
id: GO:1905940
name: negative regulation of gonad development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "down regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gonad development" EXACT [GOC:TermGenie]
synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gonad development" NARROW [GOC:TermGenie]
synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008406 ! negatively regulates gonad development
relationship: RO:0002212 GO:0008406 ! negatively regulates gonad development
creation_date: 2017-02-09T17:01:59Z

[Term]
id: GO:1905941
name: positive regulation of gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "activation of gonad development" NARROW [GOC:TermGenie]
synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gonad development" EXACT [GOC:TermGenie]
synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008406 ! positively regulates gonad development
relationship: RO:0002213 GO:0008406 ! positively regulates gonad development
creation_date: 2017-02-09T17:02:08Z

[Term]
id: GO:1905952
name: regulation of lipid localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0010876 ! regulates lipid localization
relationship: RO:0002211 GO:0010876 ! regulates lipid localization
creation_date: 2017-02-21T12:12:22Z

[Term]
id: GO:1905953
name: negative regulation of lipid localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1905952 ! regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0010876 ! negatively regulates lipid localization
relationship: RO:0002212 GO:0010876 ! negatively regulates lipid localization
creation_date: 2017-02-21T12:12:41Z

[Term]
id: GO:1905954
name: positive regulation of lipid localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "activation of lipid localisation" NARROW [GOC:TermGenie]
synonym: "activation of lipid localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905952 ! regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010876 ! positively regulates lipid localization
relationship: RO:0002213 GO:0010876 ! positively regulates lipid localization
creation_date: 2017-02-21T12:12:49Z

[Term]
id: GO:1905955
name: negative regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]
synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901509 ! regulation of endothelial tube morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis
relationship: RO:0002212 GO:0061154 ! negatively regulates endothelial tube morphogenesis
creation_date: 2017-02-21T15:17:31Z

[Term]
id: GO:1905956
name: positive regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]
synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901509 ! regulation of endothelial tube morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis
relationship: RO:0002213 GO:0061154 ! positively regulates endothelial tube morphogenesis
creation_date: 2017-02-21T15:17:39Z

[Term]
id: GO:1905962
name: glutamatergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron." [GO_REF:0000086, GOC:TermGenie, PMID:24030726]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0000679 ! results in acquisition of features of glutamatergic neuron
relationship: RO:0002315 CL:0000679 ! results in acquisition of features of glutamatergic neuron
creation_date: 2017-02-23T17:40:43Z

[Term]
id: GO:1990009
name: retinal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675]
synonym: "induction of retinal programmed cell death" RELATED []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0009004 ! occurs in retinal cell
relationship: BFO:0000066 CL:0009004 ! occurs in retinal cell
creation_date: 2012-12-12T10:15:08Z

[Term]
id: GO:1990010
name: compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768]
is_a: GO:1990009 ! retinal cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell
relationship: BFO:0000066 CL:0009001 ! occurs in compound eye retinal cell
creation_date: 2012-12-12T10:21:07Z

[Term]
id: GO:1990048
name: anterograde neuronal dense core vesicle transport
namespace: biological_process
def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451]
subset: goslim_synapse
synonym: "anterograde dense core granule trafficking" EXACT []
synonym: "anterograde dense core granule transport" EXACT []
is_a: GO:0008089 ! anterograde axonal transport
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099519 ! dense core granule cytoskeletal transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002339 GO:0098793 ! has target end location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle
relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle

[Term]
id: GO:1990049
name: retrograde neuronal dense core vesicle transport
namespace: biological_process
def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653]
subset: goslim_synapse
synonym: "retrograde dense core granule trafficking" EXACT []
synonym: "retrograde dense core granule transport" EXACT []
is_a: GO:0008090 ! retrograde axonal transport
is_a: GO:0047496 ! vesicle transport along microtubule
is_a: GO:0099519 ! dense core granule cytoskeletal transport
intersection_of: GO:0006810 ! transport
intersection_of: BFO:0000066 GO:1904115 ! occurs in axon cytoplasm
intersection_of: RO:0002338 GO:0098793 ! has target start location presynapse
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
intersection_of: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle
relationship: RO:0004009 GO:0098992 ! has primary input neuronal dense core vesicle
creation_date: 2013-02-19T13:31:44Z

[Term]
id: GO:1990182
name: exosomal secretion
namespace: biological_process
def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898]
synonym: "exosomal protein secretion" NARROW [PMID:18617898]
synonym: "exosomal secretory pathway" EXACT [PMID:18617898]
synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd]
synonym: "multi-vesicular body fusion with plasma membrane" EXACT []
synonym: "secretion of exosome" EXACT [PMID:18617898]
is_a: GO:0006887 ! exocytosis
is_a: GO:0051650 ! establishment of vesicle localization
intersection_of: GO:0006887 ! exocytosis
intersection_of: RO:0004009 GO:0070062 ! has primary input extracellular exosome
relationship: BFO:0000050 GO:0097734 ! part of extracellular exosome biogenesis
relationship: RO:0004009 GO:0070062 ! has primary input extracellular exosome
creation_date: 2013-09-04T21:08:14Z

[Term]
id: GO:1990188
name: euchromatin binding
namespace: molecular_function
def: "Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512]
is_a: GO:0003682 ! chromatin binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0000791 ! has primary input euchromatin
relationship: RO:0004009 GO:0000791 ! has primary input euchromatin
creation_date: 2013-09-11T19:18:38Z

[Term]
id: GO:1990234
name: transferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]
is_a: GO:1902494 ! catalytic complex
intersection_of: GO:1902494 ! catalytic complex
intersection_of: RO:0002215 GO:0016740 ! capable of transferase activity
relationship: RO:0002215 GO:0016740 ! capable of transferase activity
creation_date: 2013-11-12T13:20:12Z

[Term]
id: GO:1990239
name: steroid hormone binding
namespace: molecular_function
def: "Binding to a steroid hormone." [GOC:ln]
is_a: GO:0005496 ! steroid binding
is_a: GO:0042562 ! hormone binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:26764 ! has primary input
relationship: RO:0004009 CHEBI:26764 ! has primary input
creation_date: 2013-11-15T09:26:18Z

[Term]
id: GO:1990280
name: RNA localization to chromatin
namespace: biological_process
def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262]
synonym: "RNA localisation to chromatin" EXACT []
is_a: GO:0006403 ! RNA localization
intersection_of: GO:0006403 ! RNA localization
intersection_of: RO:0002339 GO:0000785 ! has target end location chromatin
relationship: RO:0002339 GO:0000785 ! has target end location chromatin
creation_date: 2014-01-30T15:55:34Z

[Term]
id: GO:1990351
name: transporter complex
namespace: cellular_component
def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]
comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: RO:0002215 GO:0005215 ! capable of transporter activity
relationship: RO:0002215 GO:0005215 ! capable of transporter activity
creation_date: 2014-03-26T14:23:27Z

[Term]
id: GO:1990497
name: regulation of cytoplasmic translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445]
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002211 GO:0002181 ! regulates cytoplasmic translation
creation_date: 2014-09-26T11:11:29Z

[Term]
id: GO:1990502
name: dense core granule maturation
namespace: biological_process
def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674]
synonym: "dense core vesicle maturation" EXACT []
is_a: GO:0061792 ! secretory granule maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: RO:0002299 GO:0031045 ! results in maturation of dense core granule
relationship: RO:0002299 GO:0031045 ! results in maturation of dense core granule
creation_date: 2014-09-30T20:35:11Z

[Term]
id: GO:1990542
name: mitochondrial transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
relationship: RO:0002342 GO:0031966 ! results in transport across mitochondrial membrane
creation_date: 2014-11-19T11:19:21Z

[Term]
id: GO:1990580
name: regulation of cytoplasmic translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975]
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: RO:0002211 GO:0002184 ! regulates cytoplasmic translational termination
relationship: RO:0002211 GO:0002184 ! regulates cytoplasmic translational termination
creation_date: 2014-12-10T15:48:55Z

[Term]
id: GO:1990611
name: regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445]
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:1904688 ! regulation of cytoplasmic translational initiation
is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002211 GO:0002183 ! regulates cytoplasmic translational initiation
creation_date: 2015-01-20T13:04:14Z

[Term]
id: GO:1990625
name: negative regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation
is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: BFO:0000050 GO:0033554 ! part of cellular response to stress
intersection_of: RO:0002212 GO:0002183 ! negatively regulates cytoplasmic translational initiation
creation_date: 2015-01-31T21:25:56Z

[Term]
id: GO:1990751
name: Schwann cell chemotaxis
namespace: biological_process
def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995]
is_a: GO:0036135 ! Schwann cell migration
is_a: GO:0060326 ! cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0002573 ! results in movement of Schwann cell
creation_date: 2015-05-21T19:19:09Z

[Term]
id: GO:1990778
name: protein localization to cell periphery
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]
is_a: GO:0008104 ! intracellular protein localization
intersection_of: GO:0008104 ! intracellular protein localization
intersection_of: RO:0002339 GO:0071944 ! has target end location cell periphery
relationship: RO:0002339 GO:0071944 ! has target end location cell periphery
creation_date: 2015-06-18T22:37:39Z

[Term]
id: GO:1990849
name: vacuolar localization
namespace: biological_process
def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797]
synonym: "maintenance of vacuolar localization" EXACT []
synonym: "maintenance of vacuolar location" NARROW []
synonym: "maintenance of vacuole localization" EXACT []
synonym: "maintenance of vacuole location" EXACT []
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: RO:0004009 GO:0005773 ! has primary input vacuole
relationship: RO:0004009 GO:0005773 ! has primary input vacuole
created_by: mcc
creation_date: 2015-09-10T08:16:02Z

[Term]
id: GO:1990863
name: acinar cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538]
synonym: "acinic cell proliferation" EXACT []
synonym: "acinous cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000622 ! acts on population of acinar cell
relationship: RO:0012003 CL:0000622 ! acts on population of acinar cell
creation_date: 2015-09-25T14:26:09Z

[Term]
id: GO:1990874
name: vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467]
synonym: "vascular smooth muscle cell proliferation" EXACT []
synonym: "VSMC proliferation" EXACT []
is_a: GO:0048659 ! smooth muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell
relationship: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell
creation_date: 2015-09-29T16:34:59Z

[Term]
id: GO:1990904
name: ribonucleoprotein complex
namespace: cellular_component
alt_id: GO:0030529
alt_id: GO:1990903
def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]
subset: goslim_pir
synonym: "extracellular ribonucleoprotein complex" NARROW []
synonym: "intracellular ribonucleoprotein complex" NARROW []
synonym: "protein-RNA complex" EXACT []
synonym: "RNA-protein complex" EXACT []
synonym: "RNP" EXACT []
xref: Wikipedia:Ribonucleoprotein
is_a: GO:0032991 ! protein-containing complex
relationship: BFO:0000051 CHEBI:33697 ! has part ribonucleic acid
created_by: pr
creation_date: 2015-11-19T12:26:37Z

[Term]
id: GO:1990917
name: ooplasm
namespace: cellular_component
def: "The cytoplasm of an ovum." [PMID:19022436]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: BFO:0000050 CL:0000025 ! part of egg cell
relationship: BFO:0000050 CL:0000025 ! part of egg cell
creation_date: 2015-12-10T21:40:16Z

[Term]
id: GO:2000026
name: regulation of multicellular organismal development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007275 ! regulates multicellular organism development
relationship: RO:0002211 GO:0007275 ! regulates multicellular organism development
creation_date: 2010-08-05T11:25:59Z

[Term]
id: GO:2000027
name: regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol]
synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis
relationship: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis
creation_date: 2010-08-05T11:26:27Z

[Term]
id: GO:2000035
name: regulation of stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol]
synonym: "regulation of stem cell renewal" EXACT [GOC:obol]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0017145 ! regulates stem cell division
relationship: RO:0002211 GO:0017145 ! regulates stem cell division
creation_date: 2010-08-05T11:34:53Z

[Term]
id: GO:2000068
name: regulation of defense response to insect
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol]
synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002213 ! regulates defense response to insect
relationship: RO:0002211 GO:0002213 ! regulates defense response to insect
creation_date: 2010-08-23T09:30:00Z

[Term]
id: GO:2000106
name: regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of leukocyte apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process
relationship: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process
creation_date: 2010-09-15T01:42:05Z

[Term]
id: GO:2000107
name: negative regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process
relationship: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic process
creation_date: 2010-09-15T01:42:09Z

[Term]
id: GO:2000108
name: positive regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process
relationship: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic process
creation_date: 2010-09-15T01:42:12Z

[Term]
id: GO:2000109
name: regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "regulation of AICD" RELATED [GOC:yaf]
synonym: "regulation of macrophage apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process
relationship: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process
creation_date: 2010-09-15T01:44:15Z

[Term]
id: GO:2000110
name: negative regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "negative regulation of AICD" RELATED [GOC:yaf]
synonym: "negative regulation of macrophage apoptosis" NARROW []
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000109 ! regulation of macrophage apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic process
relationship: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic process
creation_date: 2010-09-15T01:44:18Z

[Term]
id: GO:2000111
name: positive regulation of macrophage apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf]
synonym: "positive regulation of AICD" RELATED [GOC:yaf]
synonym: "positive regulation of macrophage apoptosis" NARROW []
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000109 ! regulation of macrophage apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic process
relationship: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic process
creation_date: 2010-09-15T01:44:21Z

[Term]
id: GO:2000114
name: regulation of establishment of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph]
synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol]
synonym: "regulation of cell polarization" EXACT [GOC:obol]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0030010 ! regulates establishment of cell polarity
relationship: RO:0002211 GO:0030010 ! regulates establishment of cell polarity
creation_date: 2010-09-16T01:22:36Z

[Term]
id: GO:2000136
name: regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis
relationship: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis
creation_date: 2010-09-29T12:43:53Z

[Term]
id: GO:2000137
name: negative regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis
relationship: RO:0002212 GO:0061323 ! negatively regulates cell proliferation involved in heart morphogenesis
creation_date: 2010-09-29T12:43:55Z

[Term]
id: GO:2000138
name: positive regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis
relationship: RO:0002213 GO:0061323 ! positively regulates cell proliferation involved in heart morphogenesis
creation_date: 2010-09-29T12:43:57Z

[Term]
id: GO:2000145
name: regulation of cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "regulation of cell locomotion" EXACT [GOC:obol]
synonym: "regulation of cell movement" RELATED [GOC:obol]
synonym: "regulation of movement of a cell" EXACT [GOC:obol]
xref: Reactome:R-HSA-6785631 "ERBB2 Regulates Cell Motility"
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048870 ! regulates cell motility
relationship: RO:0002211 GO:0048870 ! regulates cell motility
creation_date: 2010-10-01T09:41:21Z

[Term]
id: GO:2000146
name: negative regulation of cell motility
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "negative regulation of cell locomotion" EXACT [GOC:obol]
synonym: "negative regulation of cell movement" RELATED [GOC:obol]
synonym: "negative regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048870 ! negatively regulates cell motility
relationship: RO:0002212 GO:0048870 ! negatively regulates cell motility
creation_date: 2010-10-01T09:41:26Z

[Term]
id: GO:2000147
name: positive regulation of cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "positive regulation of cell locomotion" EXACT [GOC:obol]
synonym: "positive regulation of cell movement" RELATED [GOC:obol]
synonym: "positive regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048870 ! positively regulates cell motility
relationship: RO:0002213 GO:0048870 ! positively regulates cell motility
creation_date: 2010-10-01T09:41:30Z

[Term]
id: GO:2000155
name: positive regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl]
synonym: "positive regulation of ciliary cell motility" RELATED []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell motility
relationship: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell motility
creation_date: 2010-10-04T12:41:05Z

[Term]
id: GO:2000171
name: negative regulation of dendrite development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0050773 ! regulation of dendrite development
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0016358 ! negatively regulates dendrite development
relationship: RO:0002212 GO:0016358 ! negatively regulates dendrite development
creation_date: 2010-10-07T10:53:15Z

[Term]
id: GO:2000172
name: regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve
relationship: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve
creation_date: 2010-10-07T12:07:54Z

[Term]
id: GO:2000173
name: negative regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve
relationship: RO:0002212 GO:0048755 ! negatively regulates branching morphogenesis of a nerve
creation_date: 2010-10-07T12:07:56Z

[Term]
id: GO:2000174
name: regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation
relationship: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation
creation_date: 2010-10-11T10:24:30Z

[Term]
id: GO:2000175
name: negative regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differentiation
relationship: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differentiation
creation_date: 2010-10-11T10:24:33Z

[Term]
id: GO:2000176
name: positive regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002572 ! positively regulates pro-T cell differentiation
relationship: RO:0002213 GO:0002572 ! positively regulates pro-T cell differentiation
creation_date: 2010-10-11T10:24:35Z

[Term]
id: GO:2000177
name: regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation
relationship: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation
creation_date: 2010-10-13T12:40:41Z

[Term]
id: GO:2000178
name: negative regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation
relationship: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell proliferation
creation_date: 2010-10-13T12:40:43Z

[Term]
id: GO:2000179
name: positive regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation
relationship: RO:0002213 GO:0061351 ! positively regulates neural precursor cell proliferation
creation_date: 2010-10-13T12:40:45Z

[Term]
id: GO:2000181
name: negative regulation of blood vessel morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901343 ! negative regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis
relationship: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphogenesis
creation_date: 2010-10-13T12:46:31Z

[Term]
id: GO:2000194
name: regulation of female gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "regulation of ovarian development" EXACT [GOC:obol]
synonym: "regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008585 ! regulates female gonad development
relationship: RO:0002211 GO:0008585 ! regulates female gonad development
creation_date: 2010-10-19T10:45:34Z

[Term]
id: GO:2000195
name: negative regulation of female gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "negative regulation of ovarian development" EXACT [GOC:obol]
synonym: "negative regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905940 ! negative regulation of gonad development
is_a: GO:2000194 ! regulation of female gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008585 ! negatively regulates female gonad development
relationship: RO:0002212 GO:0008585 ! negatively regulates female gonad development
creation_date: 2010-10-19T10:45:38Z

[Term]
id: GO:2000196
name: positive regulation of female gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "positive regulation of ovarian development" EXACT [GOC:obol]
synonym: "positive regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905941 ! positive regulation of gonad development
is_a: GO:2000194 ! regulation of female gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008585 ! positively regulates female gonad development
relationship: RO:0002213 GO:0008585 ! positively regulates female gonad development
creation_date: 2010-10-19T10:45:41Z

[Term]
id: GO:2000197
name: regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071166 ! regulates ribonucleoprotein complex localization
relationship: RO:0002211 GO:0071166 ! regulates ribonucleoprotein complex localization
creation_date: 2010-10-26T10:35:48Z

[Term]
id: GO:2000198
name: negative regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "negative regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071166 ! negatively regulates ribonucleoprotein complex localization
relationship: RO:0002212 GO:0071166 ! negatively regulates ribonucleoprotein complex localization
creation_date: 2010-10-26T10:35:52Z

[Term]
id: GO:2000199
name: positive regulation of ribonucleoprotein complex localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]
synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol]
synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah]
synonym: "positive regulation of RNP localization" EXACT [GOC:obol]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071166 ! positively regulates ribonucleoprotein complex localization
relationship: RO:0002213 GO:0071166 ! positively regulates ribonucleoprotein complex localization
creation_date: 2010-10-26T10:35:55Z

[Term]
id: GO:2000211
name: regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006536 ! regulates glutamate metabolic process
relationship: RO:0002211 GO:0006536 ! regulates glutamate metabolic process
creation_date: 2010-11-03T02:43:51Z

[Term]
id: GO:2000212
name: negative regulation of glutamate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl]
synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol]
synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol]
synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol]
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000211 ! regulation of glutamate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006536 ! negatively regulates glutamate metabolic process
relationship: RO:0002212 GO:0006536 ! negatively regulates glutamate metabolic process
creation_date: 2010-11-03T02:43:55Z

[Term]
id: GO:2000238
name: regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046831 ! regulation of RNA export from nucleus
is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0006409 ! regulates tRNA export from nucleus
relationship: RO:0002211 GO:0006409 ! regulates tRNA export from nucleus
creation_date: 2010-11-10T12:39:33Z

[Term]
id: GO:2000239
name: negative regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046832 ! negative regulation of RNA export from nucleus
is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization
is_a: GO:2000238 ! regulation of tRNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0006409 ! negatively regulates tRNA export from nucleus
relationship: RO:0002212 GO:0006409 ! negatively regulates tRNA export from nucleus
creation_date: 2010-11-10T12:39:36Z

[Term]
id: GO:2000240
name: positive regulation of tRNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]
synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol]
synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol]
synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol]
synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol]
is_a: GO:0046833 ! positive regulation of RNA export from nucleus
is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization
is_a: GO:2000238 ! regulation of tRNA export from nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0006409 ! positively regulates tRNA export from nucleus
relationship: RO:0002213 GO:0006409 ! positively regulates tRNA export from nucleus
creation_date: 2010-11-10T12:39:38Z

[Term]
id: GO:2000241
name: regulation of reproductive process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah]
subset: gocheck_do_not_annotate
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022414 ! regulates reproductive process
relationship: RO:0002211 GO:0022414 ! regulates reproductive process
created_by: mah
creation_date: 2010-11-10T02:44:02Z

[Term]
id: GO:2000242
name: negative regulation of reproductive process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0022414 ! negatively regulates reproductive process
relationship: RO:0002212 GO:0022414 ! negatively regulates reproductive process
creation_date: 2010-11-10T02:44:05Z

[Term]
id: GO:2000243
name: positive regulation of reproductive process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0022414 ! positively regulates reproductive process
relationship: RO:0002213 GO:0022414 ! positively regulates reproductive process
creation_date: 2010-11-10T02:44:08Z

[Term]
id: GO:2000248
name: negative regulation of establishment or maintenance of neuroblast polarity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol]
synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
is_a: GO:0045769 ! negative regulation of asymmetric cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity
relationship: RO:0002212 GO:0045196 ! negatively regulates establishment or maintenance of neuroblast polarity
creation_date: 2010-11-11T11:40:34Z

[Term]
id: GO:2000269
name: regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "regulation of fibroblast apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process
relationship: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process
creation_date: 2010-11-23T01:07:23Z

[Term]
id: GO:2000270
name: negative regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "negative regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process
relationship: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic process
creation_date: 2010-11-23T01:07:27Z

[Term]
id: GO:2000271
name: positive regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "positive regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process
relationship: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic process
creation_date: 2010-11-23T01:07:29Z

[Term]
id: GO:2000272
name: negative regulation of signaling receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol]
subset: gocheck_obsoletion_candidate
synonym: "negative regulation of receptor activity" BROAD []
synonym: "negative regulation of signalling receptor activity" EXACT []
is_a: GO:0010469 ! regulation of signaling receptor activity
is_a: GO:0044092 ! negative regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0038023 ! negatively regulates signaling receptor activity
relationship: RO:0002212 GO:0038023 ! negatively regulates signaling receptor activity
creation_date: 2010-12-02T09:28:47Z

[Term]
id: GO:2000278
name: regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of DNA formation" EXACT [GOC:obol]
synonym: "regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process
relationship: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process
creation_date: 2010-12-08T04:48:15Z

[Term]
id: GO:2000279
name: negative regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of DNA formation" EXACT [GOC:obol]
synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic process
relationship: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic process
creation_date: 2010-12-08T04:48:20Z

[Term]
id: GO:2000282
name: regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol]
is_a: GO:0006521 ! regulation of amino acid metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process
relationship: RO:0002211 GO:0008652 ! regulates amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:19Z

[Term]
id: GO:2000283
name: negative regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol]
synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol]
synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of amino acid formation" EXACT [GOC:obol]
synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045763 ! negative regulation of amino acid metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process
relationship: RO:0002212 GO:0008652 ! negatively regulates amino acid biosynthetic process
creation_date: 2010-12-10T11:54:23Z

[Term]
id: GO:2000284
name: positive regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of amino acid formation" EXACT [GOC:obol]
synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
is_a: GO:2000282 ! regulation of amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process
relationship: RO:0002213 GO:0008652 ! positively regulates amino acid biosynthetic process
creation_date: 2010-12-10T11:54:27Z

[Term]
id: GO:2000287
name: positive regulation of myotome development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000290 ! regulation of myotome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0061055 ! positively regulates myotome development
relationship: RO:0002213 GO:0061055 ! positively regulates myotome development
creation_date: 2010-12-16T05:17:15Z

[Term]
id: GO:2000288
name: positive regulation of myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation
relationship: RO:0002213 GO:0051450 ! positively regulates myoblast proliferation
creation_date: 2010-12-16T05:20:52Z

[Term]
id: GO:2000290
name: regulation of myotome development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0061055 ! regulates myotome development
relationship: RO:0002211 GO:0061055 ! regulates myotome development
creation_date: 2010-12-20T10:22:05Z

[Term]
id: GO:2000291
name: regulation of myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0051450 ! regulates myoblast proliferation
relationship: RO:0002211 GO:0051450 ! regulates myoblast proliferation
creation_date: 2010-12-20T10:34:26Z

[Term]
id: GO:2000351
name: regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of endothelial cell apoptosis" NARROW []
synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process
relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process
creation_date: 2011-02-03T10:43:16Z

[Term]
id: GO:2000352
name: negative regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of endothelial cell apoptosis" NARROW []
synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process
relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process
creation_date: 2011-02-03T10:43:20Z

[Term]
id: GO:2000353
name: positive regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of endothelial cell apoptosis" NARROW []
synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process
relationship: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process
creation_date: 2011-02-03T10:43:23Z

[Term]
id: GO:2000374
name: regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072592 ! regulates oxygen metabolic process
relationship: RO:0002211 GO:0072592 ! regulates oxygen metabolic process
creation_date: 2011-02-11T02:03:32Z

[Term]
id: GO:2000377
name: regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072593 ! regulates reactive oxygen species metabolic process
relationship: RO:0002211 GO:0072593 ! regulates reactive oxygen species metabolic process
created_by: mah
creation_date: 2011-02-11T02:06:36Z

[Term]
id: GO:2000378
name: negative regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072593 ! negatively regulates reactive oxygen species metabolic process
relationship: RO:0002212 GO:0072593 ! negatively regulates reactive oxygen species metabolic process
creation_date: 2011-02-11T02:06:49Z

[Term]
id: GO:2000379
name: positive regulation of reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]
synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol]
synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072593 ! positively regulates reactive oxygen species metabolic process
relationship: RO:0002213 GO:0072593 ! positively regulates reactive oxygen species metabolic process
creation_date: 2011-02-11T02:06:57Z

[Term]
id: GO:2000380
name: regulation of mesoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007498 ! regulates mesoderm development
relationship: RO:0002211 GO:0007498 ! regulates mesoderm development
creation_date: 2011-02-15T03:09:46Z

[Term]
id: GO:2000381
name: negative regulation of mesoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007498 ! negatively regulates mesoderm development
relationship: RO:0002212 GO:0007498 ! negatively regulates mesoderm development
creation_date: 2011-02-15T03:10:02Z

[Term]
id: GO:2000382
name: positive regulation of mesoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007498 ! positively regulates mesoderm development
relationship: RO:0002213 GO:0007498 ! positively regulates mesoderm development
creation_date: 2011-02-15T03:10:12Z

[Term]
id: GO:2000383
name: regulation of ectoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0007398 ! regulates ectoderm development
relationship: RO:0002211 GO:0007398 ! regulates ectoderm development
creation_date: 2011-02-15T03:17:10Z

[Term]
id: GO:2000384
name: negative regulation of ectoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007398 ! negatively regulates ectoderm development
relationship: RO:0002212 GO:0007398 ! negatively regulates ectoderm development
creation_date: 2011-02-15T03:17:27Z

[Term]
id: GO:2000385
name: positive regulation of ectoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007398 ! positively regulates ectoderm development
relationship: RO:0002213 GO:0007398 ! positively regulates ectoderm development
creation_date: 2011-02-15T03:17:39Z

[Term]
id: GO:2000401
name: regulation of lymphocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072676 ! regulates lymphocyte migration
relationship: RO:0002211 GO:0072676 ! regulates lymphocyte migration
creation_date: 2011-02-23T10:45:19Z

[Term]
id: GO:2000402
name: negative regulation of lymphocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration
relationship: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration
creation_date: 2011-02-23T10:45:47Z

[Term]
id: GO:2000403
name: positive regulation of lymphocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration
relationship: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration
creation_date: 2011-02-23T10:46:06Z

[Term]
id: GO:2000404
name: regulation of T cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "regulation of T-cell migration" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072678 ! regulates T cell migration
relationship: RO:0002211 GO:0072678 ! regulates T cell migration
creation_date: 2011-02-23T10:48:24Z

[Term]
id: GO:2000405
name: negative regulation of T cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "negative regulation of T-cell migration" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000402 ! negative regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072678 ! negatively regulates T cell migration
relationship: RO:0002212 GO:0072678 ! negatively regulates T cell migration
creation_date: 2011-02-23T10:48:52Z

[Term]
id: GO:2000406
name: positive regulation of T cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "positive regulation of T-cell migration" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000403 ! positive regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072678 ! positively regulates T cell migration
relationship: RO:0002213 GO:0072678 ! positively regulates T cell migration
creation_date: 2011-02-23T10:49:12Z

[Term]
id: GO:2000458
name: regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050920 ! regulation of chemotaxis
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035700 ! regulates astrocyte chemotaxis
relationship: RO:0002211 GO:0035700 ! regulates astrocyte chemotaxis
creation_date: 2011-03-04T10:53:50Z

[Term]
id: GO:2000459
name: negative regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:1903976 ! negative regulation of glial cell migration
is_a: GO:2000458 ! regulation of astrocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035700 ! negatively regulates astrocyte chemotaxis
relationship: RO:0002212 GO:0035700 ! negatively regulates astrocyte chemotaxis
creation_date: 2011-03-04T10:54:28Z

[Term]
id: GO:2000464
name: positive regulation of astrocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:1903977 ! positive regulation of glial cell migration
is_a: GO:2000458 ! regulation of astrocyte chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035700 ! positively regulates astrocyte chemotaxis
relationship: RO:0002213 GO:0035700 ! positively regulates astrocyte chemotaxis
creation_date: 2011-03-04T04:43:29Z

[Term]
id: GO:2000471
name: regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration
relationship: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration
creation_date: 2011-03-09T09:34:08Z

[Term]
id: GO:2000472
name: negative regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem cell migration
relationship: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem cell migration
creation_date: 2011-03-09T09:34:54Z

[Term]
id: GO:2000473
name: positive regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem cell migration
relationship: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem cell migration
creation_date: 2011-03-09T09:35:25Z

[Term]
id: GO:2000495
name: regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis
relationship: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis
creation_date: 2011-03-18T02:18:34Z

[Term]
id: GO:2000496
name: negative regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis
relationship: RO:0002212 GO:0035736 ! negatively regulates cell proliferation involved in compound eye morphogenesis
creation_date: 2011-03-18T02:19:22Z

[Term]
id: GO:2000497
name: positive regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis
relationship: RO:0002213 GO:0035736 ! positively regulates cell proliferation involved in compound eye morphogenesis
creation_date: 2011-03-18T02:19:54Z

[Term]
id: GO:2000508
name: regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis
relationship: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis
creation_date: 2011-03-22T10:21:38Z

[Term]
id: GO:2000509
name: negative regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemotaxis
relationship: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemotaxis
creation_date: 2011-03-22T10:21:45Z

[Term]
id: GO:2000510
name: positive regulation of dendritic cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemotaxis
relationship: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemotaxis
creation_date: 2011-03-22T10:21:49Z

[Term]
id: GO:2000527
name: regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000508 ! regulation of dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis
relationship: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis
creation_date: 2011-03-23T12:18:32Z

[Term]
id: GO:2000528
name: negative regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis
is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cell chemotaxis
relationship: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cell chemotaxis
creation_date: 2011-03-23T12:18:39Z

[Term]
id: GO:2000529
name: positive regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]
is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis
is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cell chemotaxis
relationship: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cell chemotaxis
creation_date: 2011-03-23T12:18:45Z

[Term]
id: GO:2000542
name: negative regulation of gastrulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0045992 ! negative regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0007369 ! negatively regulates gastrulation
relationship: RO:0002212 GO:0007369 ! negatively regulates gastrulation
creation_date: 2011-04-01T04:10:08Z

[Term]
id: GO:2000543
name: positive regulation of gastrulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0040019 ! positive regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0007369 ! positively regulates gastrulation
relationship: RO:0002213 GO:0007369 ! positively regulates gastrulation
creation_date: 2011-04-01T04:10:15Z

[Term]
id: GO:2000547
name: regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly
relationship: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly
creation_date: 2011-04-03T07:21:55Z

[Term]
id: GO:2000548
name: negative regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "negative regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendrite assembly
relationship: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendrite assembly
creation_date: 2011-04-03T07:22:01Z

[Term]
id: GO:2000549
name: positive regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "positive regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendrite assembly
relationship: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendrite assembly
creation_date: 2011-04-03T07:22:06Z

[Term]
id: GO:2000573
name: positive regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of DNA formation" EXACT [GOC:obol]
synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic process
relationship: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic process
creation_date: 2011-04-04T10:01:20Z

[Term]
id: GO:2000647
name: negative regulation of stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation
relationship: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferation
creation_date: 2011-04-27T01:04:22Z

[Term]
id: GO:2000648
name: positive regulation of stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation
relationship: RO:0002213 GO:0072089 ! positively regulates stem cell proliferation
creation_date: 2011-04-27T01:04:25Z

[Term]
id: GO:2000668
name: regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process
relationship: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process
creation_date: 2011-05-09T07:34:16Z

[Term]
id: GO:2000669
name: negative regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apoptotic process
relationship: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apoptotic process
creation_date: 2011-05-09T07:34:21Z

[Term]
id: GO:2000670
name: positive regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097048 ! positively regulates dendritic cell apoptotic process
relationship: RO:0002213 GO:0097048 ! positively regulates dendritic cell apoptotic process
creation_date: 2011-05-09T07:34:26Z

[Term]
id: GO:2000671
name: regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process
relationship: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process
creation_date: 2011-05-09T10:56:17Z

[Term]
id: GO:2000672
name: negative regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process
relationship: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptotic process
creation_date: 2011-05-09T10:56:21Z

[Term]
id: GO:2000673
name: positive regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process
relationship: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process
creation_date: 2011-05-09T10:56:24Z

[Term]
id: GO:2000690
name: regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051890 ! regulation of cardioblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation
relationship: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast differentiation
creation_date: 2011-05-25T09:08:01Z

[Term]
id: GO:2000691
name: negative regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045662 ! negative regulation of myoblast differentiation
is_a: GO:0051892 ! negative regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation
relationship: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell myoblast differentiation
creation_date: 2011-05-25T09:08:06Z

[Term]
id: GO:2000700
name: positive regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045663 ! positive regulation of myoblast differentiation
is_a: GO:0051891 ! positive regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation
relationship: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell myoblast differentiation
creation_date: 2011-05-25T09:08:09Z

[Term]
id: GO:2000725
name: regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation
relationship: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiation
creation_date: 2011-06-08T10:51:06Z

[Term]
id: GO:2000726
name: negative regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation
relationship: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell differentiation
creation_date: 2011-06-08T10:51:11Z

[Term]
id: GO:2000727
name: positive regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation
relationship: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell differentiation
creation_date: 2011-06-08T10:51:15Z

[Term]
id: GO:2000736
name: regulation of stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0048863 ! regulates stem cell differentiation
relationship: RO:0002211 GO:0048863 ! regulates stem cell differentiation
creation_date: 2011-06-14T02:05:16Z

[Term]
id: GO:2000737
name: negative regulation of stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation
relationship: RO:0002212 GO:0048863 ! negatively regulates stem cell differentiation
creation_date: 2011-06-14T02:05:20Z

[Term]
id: GO:2000738
name: positive regulation of stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation
relationship: RO:0002213 GO:0048863 ! positively regulates stem cell differentiation
creation_date: 2011-06-14T02:05:23Z

[Term]
id: GO:2000765
name: regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0002181 ! regulates cytoplasmic translation
relationship: RO:0002211 GO:0002181 ! regulates cytoplasmic translation
creation_date: 2011-06-20T10:39:19Z

[Term]
id: GO:2000766
name: negative regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0002181 ! negatively regulates cytoplasmic translation
relationship: RO:0002212 GO:0002181 ! negatively regulates cytoplasmic translation
creation_date: 2011-06-20T10:39:23Z

[Term]
id: GO:2000767
name: positive regulation of cytoplasmic translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:2000765 ! regulation of cytoplasmic translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0002181 ! positively regulates cytoplasmic translation
relationship: RO:0002213 GO:0002181 ! positively regulates cytoplasmic translation
creation_date: 2011-06-20T10:39:26Z

[Term]
id: GO:2000785
name: regulation of autophagosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]
synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy]
synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol]
synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol]
synonym: "regulation of autophagosome formation" EXACT [GOC:obol]
synonym: "regulation of PAS formation" RELATED [GOC:obol]
is_a: GO:0044088 ! regulation of vacuole organization
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000045 ! regulates autophagosome assembly
relationship: RO:0002211 GO:0000045 ! regulates autophagosome assembly
created_by: rl
creation_date: 2011-06-24T11:19:08Z

[Term]
id: GO:2000790
name: regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development
relationship: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development
creation_date: 2011-06-24T01:53:50Z

[Term]
id: GO:2000791
name: negative regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development
relationship: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell proliferation involved in lung development
creation_date: 2011-06-24T01:53:53Z

[Term]
id: GO:2000792
name: positive regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development
relationship: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell proliferation involved in lung development
creation_date: 2011-06-24T01:53:56Z

[Term]
id: GO:2000794
name: regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis
relationship: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis
creation_date: 2011-06-25T07:22:38Z

[Term]
id: GO:2000795
name: negative regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis
relationship: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proliferation involved in lung morphogenesis
creation_date: 2011-06-25T07:22:42Z

[Term]
id: GO:2000810
name: regulation of bicellular tight junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF]
synonym: "regulation of tight junction formation" EXACT [GOC:obol]
xref: Reactome:R-HSA-8935964 "RUNX1 regulates expression of components of tight junctions"
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0070830 ! regulates bicellular tight junction assembly
relationship: RO:0002211 GO:0070830 ! regulates bicellular tight junction assembly
creation_date: 2011-07-06T01:08:28Z

[Term]
id: GO:2000818
name: negative regulation of myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation
relationship: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferation
creation_date: 2011-07-12T03:06:04Z

[Term]
id: GO:2000826
name: regulation of heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF]
synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0003007 ! regulates heart morphogenesis
relationship: RO:0002211 GO:0003007 ! regulates heart morphogenesis
creation_date: 2011-07-19T10:08:58Z

[Term]
id: GO:2000831
name: regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035929 ! regulates steroid hormone secretion
relationship: RO:0002211 GO:0035929 ! regulates steroid hormone secretion
creation_date: 2011-07-26T08:38:46Z

[Term]
id: GO:2000832
name: negative regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion
relationship: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secretion
creation_date: 2011-07-26T08:38:50Z

[Term]
id: GO:2000833
name: positive regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion
relationship: RO:0002213 GO:0035929 ! positively regulates steroid hormone secretion
creation_date: 2011-07-26T08:38:51Z

[Term]
id: GO:2000834
name: regulation of androgen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035935 ! regulates androgen secretion
relationship: RO:0002211 GO:0035935 ! regulates androgen secretion
creation_date: 2011-07-26T08:39:45Z

[Term]
id: GO:2000835
name: negative regulation of androgen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035935 ! negatively regulates androgen secretion
relationship: RO:0002212 GO:0035935 ! negatively regulates androgen secretion
creation_date: 2011-07-26T08:39:48Z

[Term]
id: GO:2000836
name: positive regulation of androgen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035935 ! positively regulates androgen secretion
relationship: RO:0002213 GO:0035935 ! positively regulates androgen secretion
creation_date: 2011-07-26T08:39:51Z

[Term]
id: GO:2000977
name: regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0021879 ! regulates forebrain neuron differentiation
relationship: RO:0002211 GO:0021879 ! regulates forebrain neuron differentiation
creation_date: 2011-08-03T12:09:12Z

[Term]
id: GO:2000978
name: negative regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:2000977 ! regulation of forebrain neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0021879 ! negatively regulates forebrain neuron differentiation
relationship: RO:0002212 GO:0021879 ! negatively regulates forebrain neuron differentiation
creation_date: 2011-08-03T12:09:16Z

[Term]
id: GO:2000979
name: positive regulation of forebrain neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol]
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:2000977 ! regulation of forebrain neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0021879 ! positively regulates forebrain neuron differentiation
relationship: RO:0002213 GO:0021879 ! positively regulates forebrain neuron differentiation
creation_date: 2011-08-03T12:09:19Z

[Term]
id: GO:2001014
name: regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation
relationship: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation
creation_date: 2011-08-11T08:54:37Z

[Term]
id: GO:2001015
name: negative regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation
relationship: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell differentiation
creation_date: 2011-08-11T08:54:41Z

[Term]
id: GO:2001016
name: positive regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation
relationship: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell differentiation
creation_date: 2011-08-11T08:54:44Z

[Term]
id: GO:2001017
name: regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0008090 ! regulates retrograde axonal transport
relationship: RO:0002211 GO:0008090 ! regulates retrograde axonal transport
creation_date: 2011-08-11T09:44:42Z

[Term]
id: GO:2001018
name: negative regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0008090 ! negatively regulates retrograde axonal transport
relationship: RO:0002212 GO:0008090 ! negatively regulates retrograde axonal transport
creation_date: 2011-08-11T09:44:46Z

[Term]
id: GO:2001019
name: positive regulation of retrograde axon cargo transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol]
synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:2001017 ! regulation of retrograde axon cargo transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008090 ! positively regulates retrograde axonal transport
relationship: RO:0002213 GO:0008090 ! positively regulates retrograde axonal transport
creation_date: 2011-08-11T09:44:49Z

[Term]
id: GO:2001026
name: regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis
relationship: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis
creation_date: 2011-08-22T01:07:26Z

[Term]
id: GO:2001027
name: negative regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chemotaxis
relationship: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chemotaxis
creation_date: 2011-08-22T01:07:31Z

[Term]
id: GO:2001028
name: positive regulation of endothelial cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF]
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:2001026 ! regulation of endothelial cell chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0035767 ! positively regulates endothelial cell chemotaxis
relationship: RO:0002213 GO:0035767 ! positively regulates endothelial cell chemotaxis
creation_date: 2011-08-22T01:07:34Z

[Term]
id: GO:2001035
name: regulation of tongue muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol]
is